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https://www.readbyqxmd.com/read/28338837/associations-of-leukocyte-telomere-length-with-aerobic-and-muscular-fitness-in-young-adults
#1
Dylan M Williams, Jessica L Buxton, Marko T Kantomaa, Tuija H Tammelin, Alexandra I F Blakemore, Marjo-Riitta Järvelin
Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952-5,205, varying by exposure-outcome analysis)...
March 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28336519/anticollagen-type-ii-antibodies-are-associated-with-an-acute-onset-rheumatoid-arthritis-phenotype-and-prognosticate-lower-degree-of-inflammation-during-5%C3%A2-years-follow-up
#2
Vivek Anand Manivel, Mohammed Mullazehi, Leonid Padyukov, Helga Westerlind, Lars Klareskog, Lars Alfredsson, Saedis Saevarsdottir, Johan Rönnelid
OBJECTIVE: Antifibrillar collagen type II (anti-CII) antibody-positive patients with rheumatoid arthritis (RA) have early but not late signs of increased inflammation and joint erosions. We wanted to replicate this in a large RA cohort, and to relate to human leukocyte antigen (HLA)-DRB1* alleles. METHODS: Anti-CII and anti-cyclic citrullinated peptide (CCP)2 were measured at baseline in 773 patients with RA from the Swedish Epidemiological Investigation in Rheumatoid Arthritis (EIRA) study with clinical follow-up data from the Swedish Rheumatology Quality Register (SRQ) registry, and 1476 with HLA-DRB1* information...
March 23, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28332718/lower-risk-for-cardiovascular-mortality-for-patients-with-root-filled-teeth-in-a-finnish-population
#3
J H Meurman, S-J Janket, M Surakka, E A Jackson, L K Ackerson, H R Fakhri, S Chogle, A Walls
AIM: To investigate the relationship of radiographic evidence of root filled teeth to cardiovascular outcomes. METHODOLOGY: Baseline data for 506 subjects including 256 angiographically verified heart disease patients and 250 matched cardiologically healthy controls participating in the Kuopio Oral Health and Heart study were collected in 1995-1996. Cardiovascular disease (CVD) mortalities were accrued until May 31(st) 2015 and appended to the baseline data. Mortality status data were obtained from the Finnish National Death Register where all mortality cases and the causes of death are compiled for all Finnish citizens...
March 23, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28329134/dynapenic-abdominal-obesity-as-a-predictor-of-worsening-disability-hospitalization-and-mortality-in-older-adults-results-from-the-inchianti-study
#4
Andrea P Rossi, Lara Bianchi, Stefano Volpato, Stefania Bandinelli, Jack Guralnik, Mauro Zamboni, Luigi Ferrucci
Background: There are relatively few prospective studies evaluating the combined effect of abdominal obesity and low muscle strength on mortality, hospitalization, and incident disability. The aim of this study was to prospectively evaluate the prognostic value of dynapenic abdominal obesity on incident disability, hospitalization, and mortality in the population of the InCHIANTI study. Methods: In 370 men and 476 women aged between 65 and 95 years, handgrip strength, waist circumference (WC), body mass index, interleukin-6, C-reactive protein, education, medications, smoking status, and comorbidities were evaluated at the baseline...
March 8, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329057/coronary-artery-calcification-and-risk-of-cardiovascular-disease-and-death-among-patients-with-chronic-kidney-disease
#5
Jing Chen, Matthew J Budoff, Muredach P Reilly, Wei Yang, Sylvia E Rosas, Mahboob Rahman, Xiaoming Zhang, Jason A Roy, Eva Lustigova, Lisa Nessel, Virginia Ford, Dominic Raj, Anna C Porter, Elsayed Z Soliman, Jackson T Wright, Myles Wolf, Jiang He
Importance: Coronary artery calcification (CAC) is highly prevalent in dialysis-naive patients with chronic kidney disease (CKD). However, there are sparse data on the association of CAC with subsequent risk of cardiovascular disease and all-cause mortality in this population. Objective: To study the prospective association of CAC with risk of cardiovascular disease and all-cause mortality among dialysis-naive patients with CKD. Design, Setting, and Participants: The prospective Chronic Renal Insufficiency Cohort study recruited adults with an estimated glomerular filtration rate of 20 to 70 mL/min/1...
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28322017/elevated-high-sensitivity-c-reactive-protein-increases-the-risk-of-microalbuminuria-in-subjects-with-cardiovascular-disease-risk-factors
#6
Shi-Kun Yang, Jun Liu, Bin Yi, Juan Mao, Xian-Ming Zhang, Yan Liu, Dan-Dan Lei, Ming Gui, Hao Zhang
Microalbuminuria is an early biomarker of kidney injury, the aim of this study was to investigate the impact of high sensitivity C-reactive protein (hs-CRP) on microalbuminuria in adults with cardiovascular disease (CVD) risk factors. A total of 5667 subjects who voluntarily attended annual health screenings in the Third Xiangya Hospital of Central South University were included in the study. Logistic regression was used to determine the validity of hs-CRP to predict the presence of microalbuminuria. In the unadjusted regression analysis, male gender (OR 2...
March 20, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28320601/coronary-atherosclerosis-in-indigenous-south-american-tsimane-a-cross-sectional-cohort-study
#7
Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas
BACKGROUND: Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with few cardiovascular risk factors, but high infectious inflammatory burden. METHODS: We did a cross-sectional cohort study including all individuals who self-identified as Tsimane and who were aged 40 years or older...
March 16, 2017: Lancet
https://www.readbyqxmd.com/read/28320383/lipoprotein-a-and-incident-type-2-diabetes-results-from-the-prospective-bruneck-study-and-a-meta-analysis-of-published-literature
#8
Ellie Paige, Katya L Masconi, Sotirios Tsimikas, Florian Kronenberg, Peter Santer, Siegfried Weger, Johann Willeit, Stefan Kiechl, Peter Willeit
AIMS: We aimed to (1) assess the association between lipoprotein(a) [Lp(a)] concentration and incident type-2 diabetes in the Bruneck study, a prospective population-based study, and (2) combine findings with evidence from published studies in a literature-based meta-analysis. METHODS: We used Cox proportional hazards models to calculate hazard ratios (HR) for incident type-2 diabetes over 20 years of follow-up in 815 participants of the Bruneck study according to their long-term average Lp(a) concentration...
March 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28298141/using-multiple-biomarkers-and-determinants-to-obtain-a-better-measurement-of-oxidative-stress-a-latent-variable-structural-equation-model-approach
#9
Ronald C Eldridge, W Dana Flanders, Roberd M Bostick, Veronika Fedirko, Myron Gross, Bharat Thyagarajan, Michael Goodman
PURPOSE: Since oxidative stress involves a variety of cellular changes, no single biomarker can serve as a complete measure of this complex biological process. The analytic technique of structural equation modeling (SEM) provides a possible solution to this problem by modeling a latent (unobserved) variable constructed from the covariance of multiple biomarkers. METHODS: Using three pooled datasets, we modeled a latent oxidative stress variable from five biomarkers related to oxidative stress: F2-isoprostanes (FIP), fluorescent oxidation products, mitochondrial DNA copy number, γ-tocopherol (Gtoc), and C-reactive protein (CRP, an inflammation marker closely linked to oxidative stress)...
March 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28293450/il-17a-levels-in-systemic-lupus-erythematosus-associated-with-inflammatory-markers-and-lower-rates-of-malignancy-and-heart-damage-evidence-for-a-dual-role
#10
Warren Raymond, Gro Ostli-Eilertsen, Sheynae Griffiths, Johannes Nossent
OBJECTIVE: The interleukin 17 (IL-17) cytokine family is involved in a number of chronic inflammatory diseases. In spite of contradictory findings and a lack of causality in clinical studies, IL-17 inhibition for systemic lupus erythematosus (SLE) has regained attention as a potential therapeutic pathway, after demonstrating disease-modifying capabilities in ankylosing spondylitis. We investigated the clinical associations of interleukin 17 A (IL-17A) in patients with SLE. MATERIAL AND METHODS: A cross-sectional study was performed involving SLE patients (n=102; age: 49 years; 86% female) recruited from a regional registry...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28287042/impact-of-crp-gene-and-additional-gene-smoking-interaction-on-ischemic-stroke-in-a-chinese-han-population
#11
Zhenggang Wu, Yujing Huang, Jing Huang, Lin Fan
AIMS: To investigate the association of C-reactive protein (CRP) gene single nucleotide polymorphisms (SNPs), additional gene-gene, and gene-smoking interaction with ischemic stroke (IS) risk. METHODS: Logistic regression is performed to investigate association between SNPs within CRP gene and IS risk. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the gene-gene and gene-smoking interaction, cross-validation consistency, the testing balanced accuracy and the sign test were calculated...
March 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28286467/smoking-exposure-loss-of-forced-expiratory-volume-in-one-second-and-the-risk-of-lung-cancer-among-patients-with-malignant-disease-who-present-with-cardiac-or-pulmonary-symptoms-a-cross-sectional-study
#12
Siegfried Wieshammer, Jens Dreyhaupt
BACKGROUND: Smokers with airway obstruction are at a higher risk of lung cancer than smokers without airway obstruction. Inflammation plays a key role in lung carcinogenesis. This single-center study prospectively assessed (i) the relationship between smoking exposure and the loss of forced expiratory volume in 1 s (FEV1) in determining lung cancer risk and (ii) the effect of lung cancer on systemic inflammation. METHODS: The study group comprised 475 consecutively enrolled patients with cancer who presented with pulmonary or cardiac symptoms...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28280316/the-impact-of-hypomagnesemia-on-erectile-dysfunction-in-elderly-non-diabetic-stage-3-and-4-chronic-kidney-disease-patients-a-prospective-cross-sectional-study
#13
Omer Toprak, Yasin Sarı, Akif Koç, Erhan Sarı, Ali Kırık
BACKGROUND: Erectile dysfunction (ED) is common in older men with chronic kidney disease. Magnesium is essential for metabolism of nitric oxide which helps in penile erection. There is little information available about the influence of serum magnesium on ED. The aim of the study was to assess the influence of hypomagnesemia on ED in elderly chronic kidney disease patients. SUBJECTS AND METHODS: A total of 372 patients aged 65-85 years, with an estimated glomerular filtration rate of 60-15 mL/min/1...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28275046/self-reported-sleep-disturbance-and-incidence-of-dementia-in-ageing-men
#14
Maria K Luojus, Soili M Lehto, Tommi Tolmunen, Anna-Katharine Brem, Eija Lönnroos, Jussi Kauhanen
BACKGROUND: Sleep disturbance is suggested to contribute to the development of dementia. However, prospective longitudinal data from middle-aged populations are scarce. METHODS: We investigated a population-based sample of 2386 men aged 42-62 years at baseline during 1984-1989. Participants having a history of mental illnesses, psychiatric medication, Parkinson's disease or dementia within 2 years after baseline (n=296) were excluded. Difficulty falling asleep or maintaining sleep, sleep duration and daytime tiredness were enquired...
April 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28270757/effectiveness-of-a-novel-qigong-meditative-movement-practice-for-impaired-health-in-flight-attendants-exposed-to-second-hand-cigarette-smoke
#15
Peter Payne, Steven Fiering, James C Leiter, David T Zava, Mardi A Crane-Godreau
This single-arm non-randomized pilot study explores an intervention to improve the health of flight attendants (FA) exposed to second-hand cigarette smoke prior to the smoking ban on commercial airlines. This group exhibits an unusual pattern of long-term pulmonary dysfunction. We report on Phase I of a two-phase clinical trial; the second Phase will be a randomized controlled trial testing digital delivery of the intervention. Subjects were recruited in the Northeastern US; testing and intervention were administered in 4 major cities...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28259636/the-typical-presentation-of-an-atypical-pathogen-during-an-outbreak-of-legionnaires-disease-in-vila-franca-de-xira-portugal-2014
#16
A Dias, A Cysneiros, F T Lopes, B von Amann, C Costa, P Dionísio, J Carvalho, V Durão, G Carvalho, F Paula, M Serrado, B Nunes, T Marques, F Froes, C Bárbara
BACKGROUND: An outbreak of Legionella pneumophila serogroup 1, with 403 cases was identified on the 7th November 2014 in Vila Franca de Xira, Portugal. Outbreak source was the wet cooling system of a local factory. Hospital Pulido Valente was one of the hospitals receiving patients with Legionnaires' disease (LD). METHODS: We describe the clinical findings and diagnostic methods used among the 43 confirmed or probable cases admitted to our department. RESULTS: 60...
March 1, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28257825/association-between-c-reactive-protein-crp-with-depression-symptom-severity-and-specific-depressive-symptoms-in-major-depression
#17
Ole Köhler-Forsberg, Henriette N Buttenschøn, Katherine E Tansey, Wolfgang Maier, Joanna Hauser, Mojca Zvezdana Dernovsek, Neven Henigsberg, Daniel Souery, Anne Farmer, Marcella Rietschel, Peter McGuffin, Katherine J Aitchison, Rudolf Uher, Ole Mors
INTRODUCTION: Population-based studies have associated inflammation, particularly higher C-reactive protein (CRP), with depressive severity, but clinical trials in major depressive disorder were rather non-specific without examining the role of gender. We aimed to investigate the association between CRP and overall depression severity including specific depressive symptoms and to examine potential gender differences. METHODS: We included 231 individuals with major depressive disorder from the Genome-Based Therapeutics Drugs for Depression (GENDEP) study...
March 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28256322/procalcitonin-is-an-independent-predictor-for-coronary-atherosclerotic-burden-in-patients-with-stable-coronary-artery-disease
#18
Alparslan Kurtul, Deniz Elcik
OBJECTIVES: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD...
February 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28251934/longitudinal-study-of-alcohol-consumption-and-hdl-concentrations-a-community-based-study
#19
Shue Huang, Junjuan Li, Gregory C Shearer, Alice H Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao
Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However, prospective data have been limited.Objective: We sought to determine the association between total alcohol intake, the type of alcohol-containing beverage, and the 6-y (2006-2012) longitudinal change in HDL-cholesterol concentrations in a community-based cohort.Design: A total of 71,379 Chinese adults (mean age: 50 y) who were free of cardiovascular diseases and cancer and did not use cholesterol-lowering agents during follow-up were included in the study...
March 1, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28239869/intra-patient-variability-in-adalimumab-drug-levels-within-and-between-cycles-in-crohn-s-disease
#20
M G Ward, P A Thwaites, L Beswick, J Hogg, G Rosella, D Van Langenberg, J Reynolds, P R Gibson, M P Sparrow
BACKGROUND: Whether therapeutic drug monitoring for adalimumab needs to be performed at trough has not been defined. AIM: To determine intra-patient adalimumab drug-level variation and to identify modulating patient and disease factors. METHODS: In this prospective observational study, adult patients with Crohn's disease established on maintenance adalimumab had drug levels measured repeatedly according to pre-defined schedules (visit 1: day 4-6, visit 2: day 7-9, trough: day 13-14) across two consecutive fortnightly cycles...
February 27, 2017: Alimentary Pharmacology & Therapeutics
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