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https://www.readbyqxmd.com/read/28437379/associations-of-lifetime-trauma-and-chronic-stress-with-c-reactive-protein-in-adults-ages-50-and-older-examining-the-moderating-role-of-perceived-control
#1
Ari J Elliot, Christopher J Mooney, Frank J Infurna, Benjamin P Chapman
OBJECTIVE: To investigate whether high perceived control mitigates systemic inflammatory risk associated with traumatic and chronic stress exposures in older adults. METHODS: A sample of community-dwelling adults ages 50 and older (N=4,779) was drawn from the Health and Retirement Study (HRS). Structural equation models tested interactions of lifetime trauma and chronic stress with mastery and perceived constraints predicting baseline levels and four-year change in C-reactive protein (CRP)...
April 21, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28434116/activation-of-the-serotonin-pathway-is-associated-with-poor-outcome-in-copd-exacerbation-results-of-a-long-term-cohort-study
#2
Marc A Meier, Manuel Ottiger, Alaadin Vögeli, Christian Steuer, Luca Bernasconi, Robert Thomann, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Werner Zimmerli, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND/INTRODUCTION: Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine. An increase of its activity is associated with severity in patients with pneumonia. In chronic obstructive pulmonary disease (COPD) patients, an elevation of serotonin has been reported. Experimental models showed that cigarette smoke inhibits monoamine oxidase (MAO) leading to higher levels of serotonin. We investigated the prognostic ability of tryptophan, serotonin, kynurenine, IDO, and tryptophan hydroxylase (TPH) to predict short- and long-term outcomes in patients with a COPD exacerbation...
April 22, 2017: Lung
https://www.readbyqxmd.com/read/28429138/prothrombotic-state-in-asthma-is-related-to-increased-levels-of-inflammatory-cytokines-il-6-and-tnf%C3%AE-in-peripheral-blood
#3
Stanislawa Bazan-Socha, Lucyna Mastalerz, Agnieszka Cybulska, Lech Zareba, Romy Kremers, Michal Zabczyk, Grazyna Pulka, Teresa Iwaniec, Coenraad Hemker, Anetta Undas
Recently, we have reported that asthma is associated with enhanced plasma thrombin formation and impaired fibrinolysis. The mechanisms underlying the prothrombotic state in this disease are unknown. Our aim was to investigate whether prothrombotic alterations in asthmatics are associated with inflammation. We studied 164 adult, white, stable asthmatics and 72 controls matched for age, sex, body mass index (BMI), and smoking. Plasma tumor necrosis factor α (TNFα), interleukin (IL)-6, and serum periostin were evaluated using ELISAs, and their associations with thrombin generation, fibrinolytic capacity, expressed as clot lysis time (CLT), and platelet markers were later analyzed...
April 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28428451/the-relation-between-serum-endostatin-level-and-carotid-atherosclerosis-in-healthy-residents-of-japan-results-from-the-kyushu-and-okinawa-population-study-kops
#4
Yoshifumi Kato, Norihiro Furusyo, Yuuki Tanaka, Takatsugu Ueyama, Sho Yamasaki, Masayuki Murata, Jun Hayashi
AIM: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. METHODS: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. RESULTS: The median endostatin level was 63...
April 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28420008/c-reactive-protein-and-cold-pressor-tolerance-in-the-general-population-the-troms%C3%A3-study
#5
Elina Iordanova Schistad, Audun Stubhaug, Anne-Sofie Furberg, Bo Lars Engdahl, Christopher Sivert Nielsen
The aim of this study was to examine whether increases in severity of subclinical inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), increased experimental pain sensitivity, measured by cold-pressor tolerance, and to test whether this relationship is independent of chronic pain. A large population-based study from 2007 to 2008, the sixth Tromsø Study, provided data from 12,981 participants. For the present analysis, complete data for 10,274 participants (age: median 58 years) were available...
March 31, 2017: Pain
https://www.readbyqxmd.com/read/28398943/cardiorespiratory-fitness-and-risk-of-fatty-liver-the-young-finns-study
#6
Kristiina S Pälve, Katja Pahkala, Emmi Suomela, Heikki Aatola, Janne Hulkkonen, Markus Juonala, Terho Lehtimäki, Tapani Rönnemaa, Jorma S A Viikari, Mika Kähönen, Nina Hutri-Kähönen, Risto Telama, Tuija Tammelin, Olli T Raitakari
PURPOSE: Fatty liver is an expanding health concern associated with metabolic disturbances and increased risk of cardiovascular disease. Experimental studies in animals have shown associations between fatty liver and cardiorespiratory fitness but limited data exist in humans. The aim of this study was to analyze the links between cardiorespiratory fitness and fatty liver in a population based sample of adults. METHODS: Participants were 463 adults (48% males) from the Cardiovascular Risk in Young Finns Study...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28397320/pregnancy-associated-plasma-protein-a-is-positively-correlated-to-first-trimester-skin-microvascular-reactivity
#7
C Iacobaeus, T Kahan, G Jörneskog, K Bremme, E Andolf, M Thorsell
OBJECTIVE: To investigate if there is a correlation between levels of circulating maternal pregnancy-associated plasma protein A (PAPP-A) and first trimester maternal vascular function. METHODS: A cross-sectional study of 53 healthy non-smoking, pregnant, nulliparous women in Stockholm, Sweden. PAPP-A and vascular function were assessed during gestational week 11-14. Forearm skin microcirculation was investigated by laser Doppler perfusion imaging during iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to assess endothelium dependent and endothelium independent microvascular vasodilatation, respectively...
April 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28389492/external-validation-and-extension-of-a-diagnostic-model-for-obstructive-coronary-artery-disease-a-cross-sectional-predictive-evaluation-in-4888-patients-of-the-austrian-coronary-artery-disease-risk-determination-in-innsbruck-by-diagnostic-angiography-cardiigan
#8
Michael Edlinger, Maria Wanitschek, Jakob Dörler, Hanno Ulmer, Hannes F Alber, Ewout W Steyerberg
OBJECTIVE: To externally validate and extend a recently proposed prediction model to diagnose obstructive coronary artery disease (CAD), with the ultimate aim to better select patients for coronary angiography. DESIGN: Analysis of individual baseline data of a prospective cardiology cohort. SETTING: Single-centre secondary and tertiary cardiology clinic. PARTICIPANTS: 4888 patients with suspected CAD, without known previous CAD or other heart diseases, who underwent an elective coronary angiography between 2004 and 2008 as part of the prospective Coronary Artery disease Risk Determination In Innsbruck by diaGnostic ANgiography (CARDIIGAN) cohort...
April 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28384120/dyslipidemia-in-subclinical-hypothyroidism-requires-assessment-of-small-dense-low-density-lipoprotein-cholesterol-sdldl-c
#9
Maida Seferovic Saric, Miljenka-Jelena Jurasic, Slavica Sovic, Bojana Kranjcec, Tatjana Glivetic, Vida Demarin
BACKGROUND: Usually both hypothyroidism and hyperthyroidism are related to the cardiovascular and cerebrovascular disease development. The relationship between subclinical hypothyroidism has been widely investigated but the findings remain controversial. The aim of the present study was to evaluate the lipid profile in patients with subclinical hypothyroidism (SHypo) in comparison to controls and to determine the association of SHypo and dyslipidemia in attempt to find importance of small dense low-density lipoprotein cholesterol (sdLDL-C) in atherosclerosis...
April 6, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28376532/sleep-duration-and-c-reactive-protein-in-us-adults
#10
Michael R Richardson, James R Churilla
OBJECTIVE: To use gender-stratified logistic regression analysis to examine the associations between elevated C-reactive protein (CRP; >3-10 mg/L) and sleep duration. METHODS: The study sample included male (n = 5033) and female (n = 4917) adult (20 years old and older) participants in the 2007-2010 National Health and Nutrition Examination Survey. Sleep duration was categorized as short (≤6 hours/day), adequate (7-8 hours/day), or long (≥9 hours/day). Logistic regression models were adjusted for age, race, smoking status, physical activity, and waist circumference...
April 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28375782/the-potential-hazardous-effect-of-exposure-to-iron-dust-in-egyptian-smoking-and-non-smoking-welders
#11
Naglaa Abd El Khalik Gobba, Abdel-Maksoud A Hussien, Dalia E El Sharawy, Mohammed Abdalla Hussein
Exposure to iron dust and welding fumes is widespread and may increase the risk of lung inflammation. The aim of this study was to identify associations between exposure to iron/ welding fumes and the levels of inflammatory parameters and allergic mediators among 120 Egyptian males. Forty non-smoking and 40 smoking Egyptian welders as well as 40 healthy volunteers who were never exposed to welding fumes and non-smoking were enrolled in the study. Peak expiratory flow rates (PEFR) that were assessed at the shift of work in the working days revealed an impairment in lung function with the smoking workers showing the worse results, followed by the non-smoking ones as compared to the healthy volunteers...
April 4, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28368304/pre-pregnancy-body-mass-index-is-associated-with-dietary-inflammatory-index-and-c-reactive-protein-concentrations-during-pregnancy
#12
Dayeon Shin, Junguk Hur, Eun-Hee Cho, Hae-Kyung Chung, Nitin Shivappa, Michael D Wirth, James R Hébert, Kyung Won Lee
There have been a limited number of studies examining the association between pre-pregnancy body mass index (BMI) and dietary inflammation during pregnancy. Our aim is to examine the association between pre-pregnancy BMI and the Dietary Inflammatory Index (DII)™ and C-reactive protein (CRP) concentrations during pregnancy. The study included 631 pregnant American women from the National Health and Nutrition Examination Survey (NHANES) cross-sectional examinations from 2003 to 2012. Pre-pregnancy BMI was calculated based on self-reported pre-pregnancy weight and measured height...
April 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28365380/unemployment-and-inflammatory-markers-in-england-wales-and-scotland-1998-2012-meta-analysis-of-results-from-12-studies
#13
Amanda Hughes, Meena Kumari, Anne McMunn, Mel Bartley
INTRODUCTION: Unemployment may represent a substantial source of psychosocial stress, and is linked to both increased risk of morbidity and mortality and adverse health-related behaviours. Few studies have examined the association of unemployment with systemic inflammation, a plausible mediator of the associations of psychosocial stress and health, and results are mixed and context dependent. This study examines the association of unemployment with C-reactive protein (CRP) and fibrinogen, two markers of systemic inflammation...
March 29, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28359359/association-between-polyunsaturated-fatty-acids-and-inflammatory-markers-in-patients-in-secondary-prevention-of%C3%A2-cardiovascular-disease
#14
Ângela Cristine Bersch-Ferreira, Geni Rodrigues Sampaio, Marcella Omena Gehringer, Maria Beatriz Ross-Fernandes, Cristiane Kovacs, Renata Alves, Jaqueline Lopes Pereira, Carlos Daniel Magnoni, Bernardete Weber, Marcelo Macedo Rogero
OBJECTIVE: The aim of this study was to assess the association between polyunsaturated fatty acids (PUFAs) and inflammatory biomarkers among patients in secondary prevention of cardiovascular disease (CVD). METHODS: In this cross-sectional substudy from BALANCE Program Trial, we have collected data from 364 patients with established CVD. Twenty-four-hour dietary recalls and plasma FA concentrations were analyzed to estimate the FA intake. Inflammatory biomarkers measurement consisted of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, C-reactive protein, adiponectin, and tumor necrosis factor-α...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28356730/plasminogen-activator-inhibitor-1-is-elevated-in-patients-with-copd-independent-of-metabolic-and-cardiovascular-function
#15
Benjamin Waschki, Henrik Watz, Olaf Holz, Helgo Magnussen, Beata Olejnicka, Tobias Welte, Klaus F Rabe, Sabina Janciauskiene
INTRODUCTION: Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD). The role of PAI-1 in COPD with respect to metabolic and cardiovascular functions is unclear. METHODS: In this study, which was nested within a prospective cohort study, the serum levels of PAI-1 were cross-sectionally measured in 74 stable COPD patients (Global Initiative for Chronic Obstructive Lung Disease [GOLD] Stages I-IV) and 18 controls without lung disease...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28351393/effects-of-honey-supplementation-on-inflammatory-markers-among-chronic-smokers-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Wan Syaheedah Wan Ghazali, Aminah Che Romli, Mahaneem Mohamed
BACKGROUND: Honey has been demonstrated to possess anti-inflammatory property. This is a randomized, controlled, open-label trial to determine the effects of 12-week honey oral supplementation on plasma inflammatory markers such as high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-α among chronic smokers. METHODS/DESIGN: A total of 32 non-smokers and 64 chronic smokers from Quit Smoking Clinic and Health Campus, Universiti Sains Malaysia participated in the study...
March 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28349880/anti-inflammatory-and-antithrombotic-effects-of-nicotine-exposure-in-oral-contraceptive-induced-insulin-resistance-is-glucocorticoid-independent
#17
Lawrence Aderemi Olatunji, Olugbenga Samuel Michael, Oluwaseun Aremu Adeyanju, Emmanuel Damilare Areola, Ayodele Olufemi Soladoye
BACKGROUND: Reports showed that estrogen-progestin oral contraceptive (COC) or tobacco smoking causes increased risk of cardiovascular diseases (CVD) in premenopausal women. Studies also suggest that nicotine; a major tobacco alkaloid may worsen or improve atherothrombotic CVD. Altered hemorheology, prothrombotic and pro-inflammatory biomarkers, have been implicated in the development of atherothrombotic CVD events. However, the effect of non-smoking nicotine exposure on these biomarkers during COC treatment is not yet established...
December 19, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28349255/alcohol-and-red-wine-consumption-but-not-fruit-vegetables-fish-or-dairy-products-are-associated-with-less-endothelial-dysfunction-and-less-low-grade-inflammation-the-hoorn-study
#18
B C T van Bussel, R M A Henry, C G Schalkwijk, J M Dekker, G Nijpels, E J M Feskens, C D A Stehouwer
PURPOSE: Endothelial dysfunction and low-grade inflammation are key phenomena in the pathobiology of cardiovascular disease (CVD). Their dietary modification might explain the observed reduction in CVD that has been associated with a healthy diet rich in fruit, vegetables and fish, low in dairy products and with moderate alcohol and red wine consumption. We investigated the associations between the above food groups and endothelial dysfunction and low-grade inflammation in a population-based cohort of Dutch elderly individuals...
March 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28348498/markers-of-systemic-inflammation-and-colorectal-adenoma-risk-meta-analysis-of-observational-studies
#19
Justyna Godos, Antonio Biondi, Fabio Galvano, Francesco Basile, Salvatore Sciacca, Edward L Giovannucci, Giuseppe Grosso
AIM: To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma. METHODS: PubMed and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios (ORs) with 95%CIs for the highest vs lowest category of exposure...
March 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28338837/associations-of-leukocyte-telomere-length-with-aerobic-and-muscular-fitness-in-young-adults
#20
Dylan M Williams, Jessica L Buxton, Marko T Kantomaa, Tuija H Tammelin, Alexandra I F Blakemore, Marjo-Riitta Järvelin
Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952-5,205, varying by exposure-outcome analysis)...
April 1, 2017: American Journal of Epidemiology
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