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https://www.readbyqxmd.com/read/29883306/evaluating-suspected-pulmonary-hypertension-a-structured-approach
#1
REVIEW
Akshay Bhatnagar, Jonathan Wiesen, Raed Dweik, Neal F Chaisson
Pulmonary arterial hypertension (PAH) is a common consideration when patients have unexplained signs of cardiopulmonary disease. Guidelines have been issued regarding diagnosis and management of this condition. Since multiple conditions can mimic components of PAH, the clinician should think about the patient's total clinical condition before diagnosing and categorizing it. Proper evaluation and etiologic definition are crucial to providing the appropriate therapy. This review offers a case-based guide to the evaluation of patients with suspected PAH...
June 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29867986/protection-against-arthritis-by-the-parasitic-worm-product-es-62-and-its-drug-like-small-molecule-analogues-is-associated-with-inhibition-of-osteoclastogenesis
#2
James Doonan, Felicity E Lumb, Miguel A Pineda, Anuradha Tarafdar, Jenny Crowe, Aneesah M Khan, Colin J Suckling, Margaret M Harnett, William Harnett
The immunomodulatory actions of parasitic helminth excretory-secretory (ES) products that serendipitously protect against development of chronic inflammatory disorders are well established: however, knowledge of the interaction between ES products and the host musculoskeletal system in such diseases is limited. In this study, we have focused on ES-62, a glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae that is immunomodulatory by virtue of covalently attached phosphorylcholine (PC) moieties, and also two synthetic drug-like PC-based small molecule analogues (SMAs) that mimic ES-62's immunomodulatory activity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29844864/microrna-146a-suppresses-rheumatoid-arthritis-fibroblast-like-synoviocytes-proliferation-and-inflammatory-responses-by-inhibiting-the-tlr4-nf-kb-signaling
#3
Wei Liu, Yuan-Hao Wu, Lei Zhang, Bin Xue, Yi Wang, Bin Liu, Xiao-Ya Liu, Fang Zuo, Xiao-Yan Yang, Fu-Yu Chen, Ran Duan, Yue Cai, Bo Zhang, Yang Ji
This study investigated whether microRNA-146a (miR-146a) mediating TLR4/NF-κB pathway affected proliferation and inflammatory responses of rheumatoid arthritis fibroblast-like synoviocytes from 12 RA patients (RA-FLSs). FLSs in the logarithmic growth phase were assigned into the control, miR-146a mimic miR-146a inhibitor, Tak-242 (treated with TLR4/NF-κB pathway inhibitor) and mimic + lipopolysaccharide (LPS) groups. Cell proliferation and apoptosis were detected using CCK-8 assay and flow cytometry. The expression of miR-146a, TLR4/NF-κB pathway-related proteins and cytokines were determined by RT-qPCR, western blotting and ELISA, and the release of NO by Greiss reaction...
May 8, 2018: Oncotarget
https://www.readbyqxmd.com/read/29712771/igg-immunocomplexes-sensitize-human-monocytes-for-inflammatory-hyperactivity-via-transcriptomic-and-epigenetic-reprogramming-in-rheumatoid-arthritis
#4
Qiao Zhong, Fang-Yuan Gong, Zheng Gong, Sheng-Hao Hua, Ke-Qin Zeng, Xiao-Ming Gao
Prevalence of circulating immunocomplexes (ICs) strongly correlates with rheumatoid arthritis (RA) in humans. Deposits of IgG-ICs are abundant in affected joints of patients, yet molecular mechanisms for the pathogenic roles of such ICs are not fully understood. In this study, we present evidence that IgG-ICs precipitated from RA sera sensitized human monocytes for a long-lasting inflammatory functional state, characterized by a strong TNF-α response to cellular proteins representing damage-associated molecular patterns and microbe-derived pathogen-associated molecular patterns...
June 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29692623/nephritis-cerebritis-and-myositis-after-adalimumab-therapy-in-a-patient-with-rheumatoid-arthritis-a-case-report
#5
Narges E Omran, Abdulsalam A Noorwali
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects the joints, therefore, may cause deformities and disability if untreated. The first line of treatment is disease-modifying antirheumatic drugs (DMARDs). When the patient fails to respond to DMARDs, mainly methotrexate, then second-line therapy is required. Tumor necrosis factor α (TNFα) plays an important role in the pathogenesis of RA; however, the treatment with anti-TNFα medications is challenging. It may trigger the autoimmune system and result in producing antibodies that induce symptoms and signs mimic to systemic lupus erythematosus (SLE), and in rare situations can affect vital organs with severe and life-threatening complications...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29691581/-upregulation-of-mir-498-suppresses-th17-cell-differentiation-by-targeting-stat3-in-rheumatoid-arthritis-patients
#6
Hai-Yan Xiang, Feng Pan, Ju-Zhen Yan, Li-Quan Hong, La-Hong Zhang, Yu-Hua Liu, Xiao Feng, Cheng-Song Cai
To investigate the effect and mechanism of miR-498 on Th17 cell differentiation of peripheral blood mononuclear cells (PMBCs) in rheumatoid arthritis (RA) patients, peripheral blood samples were collected from RA patients and healthy controls, respectively. The proportion of CD4+ IL-17+ T cells (Th17 cells) or CD4+ FOXP3+ T cells (Tregs) in T cells and the Th17/Treg ratio were identified by the flow cytometer. The STAT3 and miR-498 expression were measured by Western blot and real-time PCR, respectively. ELISA was used to detect IL-17 concentrations...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29626254/cul4b-promotes-the-pathology-of-adjuvant-induced-arthritis-in-rats-through-the-canonical-wnt-signaling
#7
Chenggui Miao, Jun Chang, Guoxue Zhang, Hao Yu, Lili Zhou, Guoliang Zhou, Chuanlei Zhao
This work aims to discuss the possibility that disordered CUL4B was involved in the pathogenesis of adjuvant-induced arthritis (AIA) in rats. Synovium and FLS from AIA rats both showed increased CUL4B and β-catenin, and up-regulated CUL4B enhanced the canonical Wnt signaling by targeting the GSK3β. Increased CUL4B promoted the FLS abnormal proliferation, activated the secretion of IL-1β and IL-8, and promoted the production of AIA pathology gene MMP3 and fibronectin. Furthermore, miR-101-3p was significantly down-regulated in AIA rats compared with controls, and transfection of AIA FLS with miR-101-3p mimics significantly down-regulated the CUL4B expression, whereas transfection with miR-101-3p inhibitors resulted in an opposite observation...
June 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29545315/down-regulation-of-mir-10a-5p-promotes-proliferation-and-restricts-apoptosis-via-targeting-t-box-transcription-factor-5-in-inflamed-synoviocytes
#8
Nazim Hussain, Wenhua Zhu, Congshan Jiang, Jing Xu, Manman Geng, Xiaoying Wu, Safdar Hussain, Bo Wang, Muhammad Shahid Riaz Rajoka, Yue Li, Juan Tian, Liesu Meng, Shemin Lu
Synoviocytes from rheumatoid arthritis (RA) patients share certain features with tumor cells, such as over proliferation and invasion. Anomalous microRNA (miRNA) expression may participate in the pathogenesis of RA in different ways. The objective of the present study was to observe the role of miR-10a-5p targeting T-box transcription factor 5 (TBX5) gene on synoviocyte proliferation and apoptosis in RA. Human synovial sarcoma cell line, SW982 cells stimulating with interleukin-1β (IL-1β) were transfected with miR-10a-5p mimic and siRNA of TBX5...
April 27, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29536378/a-case-report-of-chikungunya-fever-rheumatoid-arthritis-and-felty-s-syndrome
#9
José Kennedy Amaral, Robert T Schoen
INTRODUCTION: Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA). CASE REPORT: We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK arthritis not only resembling RA clinically, but also associated with RA biomarkers and extra-articular features, including Felty's syndrome (FS)...
June 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29475367/mir-148b-3p-affects-the-pathogenesis-of-adjuvant-induced-arthritis-rats-through-the-direct-target-dnmt1
#10
Chenggui Miao, Hao Yu, Jun Chang, Guoxue Zhang, Guoliang Zhou, Chuanlei Zhao
Our previous study showed that up-regulated DNA methyltransferase-1 (DNMT1) played an important role in the hypermethylation modification of SFRP4 in adjuvant-induced arthritis (AIA) rats. This work focused on the role of disordered miR-148b-3p in RA pathology and its corresponding regulatory targets. The expression of miR-148b-3p and DNMT1, and the effect of miR-148b-3p on the DNMT1 expression were determined by real-time qPCR, western blotting and double luciferase reporter genes. The role of miR-148b-3p on the SFRP4 expression, the canonical Wnt signaling and the pathology of AIA rats was investigated using real-time qPCR, western blotting and methylation-specific PCR (MSP)...
March 2018: Autoimmunity
https://www.readbyqxmd.com/read/29424904/mir-212-3p-reduced-proliferation-and-promoted-apoptosis-of-fibroblast-like-synoviocytes-via-down-regulating-sox5-in-rheumatoid-arthritis
#11
Y Liu, X-L Zhang, X-F Li, Y-C Tang, X Zhao
OBJECTIVE: Several microRNAs have been reported to contribute the progression of rheumatoid arthritis (RA) due to the ectopic expression of miRNAs in fibroblast-like synoviocytes (FLS). However, the function of miR-212-3p in RA still has not been mentioned before. PATIENTS AND METHODS: We obtained serum, synovial tissues, and FLS samples from RA patients and normal donors. Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to analysis the expression level of miR-212-3p...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29326073/retinoic-acid-promotes-stem-cell-differentiation-and-embryonic-development-by-transcriptionally-activating-cftr
#12
Xiaofeng Li, Kin Lam Fok, Jinghui Guo, Yan Wang, Zhenqing Liu, Ziyi Chen, Chengdong Wang, Ye Chun Ruan, Sidney Siubun Yu, Hui Zhao, Ji Wu, Xiaohua Jiang, Hsiao Chang Chan
Retinoic acid (RA) plays a pivotal role in many cellular processes; however, the signaling mechanisms mediating the effect of RA are not fully understood. Here, we show that RA transcriptionally upregulates cystic fibrosis transmembrane conductance regulator (Cftr) by promoting the direct binding of its receptor RARα to Cftr promoter in mouse spermatogonia and embryonic stem (ES) cells. The RA/CFTR pathway is involved in the differentiation of spermatogonia and organogenesis during the embryo development of Xenopus laevis...
April 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29279319/survival-of-cancer-stem-like-cells-under-metabolic-stress-via-camk2%C3%AE-mediated-upregulation-of-sarco-endoplasmic-reticulum-calcium-atpase-expression
#13
Ki Cheong Park, Seung Won Kim, Jeong Yong Jeon, A Ra Jo, Hye Ji Choi, Jungmin Kim, Hyun Gyu Lee, Yonjung Kim, Gordon B Mills, Sung Hoon Noh, Min Goo Lee, Eun Sung Park, Jae-Ho Cheong
Purpose: Cancer cells grow in an unfavorable metabolic milieu in the tumor microenvironment and are constantly exposed to metabolic stress such as chronic nutrient depletion. Cancer stem-like cells (CSC) are intrinsically resistant to metabolic stress, thereby surviving nutrient insufficiency and driving more malignant tumor progression. In this study, we aimed to demonstrate the potential mechanisms by which CSCs avoid Ca2+ -dependent apoptosis during glucose deprivation. Experimental Design: We investigated cell viability and apoptosis under glucose deprivation, performed genome-wide transcriptional profiling of paired CSCs and parental cells, studied the effect of calcium/calmodulin-dependent protein kinase 2 alpha ( CaMK2α ) gene knockdown, and investigated the role of nuclear factor kappa B (NFκB) in CSCs during time-dependent Ca2+ -mediated and glucose deprivation-induced apoptosis...
April 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29276516/myostatin-promotes-interleukin-1%C3%AE-expression-in-rheumatoid-arthritis-synovial-fibroblasts-through-inhibition-of-mir-21-5p
#14
Sung-Lin Hu, An-Chen Chang, Chien-Chung Huang, Chun-Hao Tsai, Cheng-Chieh Lin, Chih-Hsin Tang
Rheumatoid arthritis (RA) is characterized by the infiltration of a number of pro-inflammatory cytokines into synovial fluid and patients with RA often develop joint destruction and deficits in muscle mass. The growth factor myostatin is a key regulator linking muscle mass and bone structure. We sought to determine whether myostatin regulates rheumatoid synovial fibroblast activity and inflammation in RA. We found that levels of myostatin and interleukin (IL)-1β (a key pro-inflammatory cytokine in RA) in synovial fluid from RA patients were overexpressed and positively correlated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29193612/a-direct-role-for-hepatitis-b-virus-x-protein-in-inducing-mitochondrial-membrane-permeabilization
#15
H-R Lee, Y Y Cho, G Y Lee, D-G You, Y D Yoo, Y J Kim
Hepatitis B virus X protein (HBx) acts as a multifunctional protein that regulates intracellular signalling pathways during HBV infection. It has mainly been studied in terms of its interaction with cellular proteins. Here, we show that HBx induces membrane permeabilization independently of the mitochondrial permeability transition pore complex. We generated mitochondrial outer membrane-mimic liposomes to observe the direct effects of HBx on membranes. We found that HBx induced membrane permeabilization, and the region comprising the transmembrane domain and the mitochondrial-targeting sequence was sufficient for this process...
April 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29191214/the-role-of-aberrant-expression-of-t-cell-mirnas-affected-by-tnf-%C3%AE-in-the-immunopathogenesis-of-rheumatoid-arthritis
#16
Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) can cause diverse T cell dysfunctions in patients with rheumatoid arthritis (RA). It is involved in the regulation of microRNAs (miRNAs) expression in different cell types. We hypothesized that the expression of T cell miRNAs would be affected by TNF-α, and these miRNAs could participate in the immunopathogenesis of RA. METHODS: Expression profiles of 270 human miRNAs in Jurkat cells, cultured in the presence or absence of TNF-α for 7 days were analyzed by real-time polymerase chain reaction...
December 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29156570/random-access-performance-of-distributed-sensors-attacked-by-unknown-jammers
#17
Dae-Kyo Jeong, Jung-Hwa Wui, Dongwoo Kim
In this paper, we model and investigate the random access (RA) performance of sensor nodes (SN) in a wireless sensor network (WSN). In the WSN, a central head sensor (HS) collects the information from distributed SNs, and jammers disturb the information transmission primarily by generating interference. In this paper, two jamming attacks are considered: power and code jamming. Power jammers (if they are friendly jammers) generate noises and, as a result, degrade the quality of the signal from SNs. Power jamming is equally harmful to all the SNs that are accessing HS and simply induces denial of service (DoS) without any need to hack HS or SNs...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29060239/modified-thresholding-technique-of-mmspca-for-extracting-respiratory-activity-from-short-length-ppg-signal
#18
Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami
In this paper, we propose an automatic threshold selection of modified multi scale principal component analysis (MMSPCA) for reliable extraction of respiratory activity (RA) from short length photoplethysmographic (PPG) signals. MMSPCA was applied to the PPG signal with a varying data length, from 30 seconds to 60 seconds, to extract the respiratory activity. To examine the performance, we used 100 epochs of simultaneously recorded PPG and respiratory signals extracted from the MIMIC database (Physionet ATM data bank)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28975975/mir-20a-regulates-fibroblast-like-synoviocyte-proliferation-and-apoptosis-in-rheumatoid-arthritis
#19
X-J Wei, X-W Li, J-L Lu, Z-X Long, J-Q Liang, S-B Wei, C-X Lu, W-Z Lu
OBJECTIVE: STAT3 expression is elevated in the synovial tissue of patients with rheumatoid arthritis (RA). MiR-20a plays a role in mediating synovial inflammation in RA. Bioinformatics analysis has identified a binding site between miR-20 and the 3'-UTR of STAT3 mRNA. This study aimed to investigate the role of miR-20a in the regulation of STAT3 expression and synovial cell proliferation as well as apoptosis. PATIENTS AND METHODS: Synovial tissues were collected from RA patients and osteoarthritis (OA) patients to measure miR-20a, STAT3, p-STAT3, and Ki-67 expressions...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28968705/a-comparative-study-of-rank-aggregation-methods-for-partial-and-top-ranked-lists-in-genomic-applications
#20
Xue Li, Xinlei Wang, Guanghua Xiao
Rank aggregation (RA), the process of combining multiple ranked lists into a single ranking, has played an important role in integrating information from individual genomic studies that address the same biological question. In previous research, attention has been focused on aggregating full lists. However, partial and/or top ranked lists are prevalent because of the great heterogeneity of genomic studies and limited resources for follow-up investigation. To be able to handle such lists, some ad hoc adjustments have been suggested in the past, but how RA methods perform on them (after the adjustments) has never been fully evaluated...
August 22, 2017: Briefings in Bioinformatics
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