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RA mimics

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https://www.readbyqxmd.com/read/29193612/a-direct-role-for-hepatitis-b-virus-x-protein-in-inducing-mitochondrial-membrane-permeabilization
#1
Hye-Ra Lee, Young Youn Cho, Gi Young Lee, Deok-Gyun You, Young Do Yoo, Yoon Jun Kim
Hepatitis B virus X protein (HBx) acts as a multifunctional protein that regulates intracellular signaling pathways during HBV infection. It has mainly been studied in terms of its interaction with cellular proteins. Here, we show that HBx induces membrane permeabilization independently of the mitochondrial permeability transition pore complex. We generated mitochondrial outer membrane-mimic liposomes to observe the direct effects of HBx on membranes. We found that HBx induced membrane permeabilization, and the region comprising the transmembrane domain and the mitochondrial targeting sequence was sufficient for this process...
November 28, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29191214/the-role-of-aberrant-expression-of-t-cell-mirnas-affected-by-tnf-%C3%AE-in-the-immunopathogenesis-of-rheumatoid-arthritis
#2
Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) can cause diverse T cell dysfunctions in patients with rheumatoid arthritis (RA). It is involved in the regulation of microRNAs (miRNAs) expression in different cell types. We hypothesized that the expression of T cell miRNAs would be affected by TNF-α, and these miRNAs could participate in the immunopathogenesis of RA. METHODS: Expression profiles of 270 human miRNAs in Jurkat cells, cultured in the presence or absence of TNF-α for 7 days were analyzed by real-time polymerase chain reaction...
December 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29156570/random-access-performance-of-distributed-sensors-attacked-by-unknown-jammers
#3
Dae-Kyo Jeong, Jung-Hwa Wui, Dongwoo Kim
In this paper, we model and investigate the random access (RA) performance of sensor nodes (SN) in a wireless sensor network (WSN). In the WSN, a central head sensor (HS) collects the information from distributed SNs, and jammers disturb the information transmission primarily by generating interference. In this paper, two jamming attacks are considered: power and code jamming. Power jammers (if they are friendly jammers) generate noises and, as a result, degrade the quality of the signal from SNs. Power jamming is equally harmful to all the SNs that are accessing HS and simply induces denial of service (DoS) without any need to hack HS or SNs...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29060239/modified-thresholding-technique-of-mmspca-for-extracting-respiratory-activity-from-short-length-ppg-signal
#4
Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami
In this paper, we propose an automatic threshold selection of modified multi scale principal component analysis (MMSPCA) for reliable extraction of respiratory activity (RA) from short length photoplethysmographic (PPG) signals. MMSPCA was applied to the PPG signal with a varying data length, from 30 seconds to 60 seconds, to extract the respiratory activity. To examine the performance, we used 100 epochs of simultaneously recorded PPG and respiratory signals extracted from the MIMIC database (Physionet ATM data bank)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28975975/mir-20a-regulates-fibroblast-like-synoviocyte-proliferation-and-apoptosis-in-rheumatoid-arthritis
#5
X-J Wei, X-W Li, J-L Lu, Z-X Long, J-Q Liang, S-B Wei, C-X Lu, W-Z Lu
OBJECTIVE: STAT3 expression is elevated in the synovial tissue of patients with rheumatoid arthritis (RA). MiR-20a plays a role in mediating synovial inflammation in RA. Bioinformatics analysis has identified a binding site between miR-20 and the 3'-UTR of STAT3 mRNA. This study aimed to investigate the role of miR-20a in the regulation of STAT3 expression and synovial cell proliferation as well as apoptosis. PATIENTS AND METHODS: Synovial tissues were collected from RA patients and osteoarthritis (OA) patients to measure miR-20a, STAT3, p-STAT3, and Ki-67 expressions...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28968705/a-comparative-study-of-rank-aggregation-methods-for-partial-and-top-ranked-lists-in-genomic-applications
#6
Xue Li, Xinlei Wang, Guanghua Xiao
Rank aggregation (RA), the process of combining multiple ranked lists into a single ranking, has played an important role in integrating information from individual genomic studies that address the same biological question. In previous research, attention has been focused on aggregating full lists. However, partial and/or top ranked lists are prevalent because of the great heterogeneity of genomic studies and limited resources for follow-up investigation. To be able to handle such lists, some ad hoc adjustments have been suggested in the past, but how RA methods perform on them (after the adjustments) has never been fully evaluated...
August 22, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28965939/impaired-intracellular-pathogen-clearance-and-inflammatory-joint-disease-is-whipple-s-disease-a-guiding-light
#7
Jean-Marie Berthelot, Xavier Puéchal
Whipple's disease can mimic spondyloarthritis (SpA) or rheumatoid arthritis (RA) for many years and, in a few cases, induces the development of antibodies to cyclic citrullinated peptides. The causative agent Tropheryma whipplei can smolder within cells, including macrophages, by suppressing the xenophagic process, a type of selective autophagy that targets pathogens. Other inflammatory joint diseases may also stem from impaired xenophagy with persistence of bacteria or viruses that can eventually migrate from the mucous membranes to the joints and entheses, where they may exert adverse effects on immune responses, even if they fail to replicate...
September 28, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28957555/downregulation-of-mir-106b-attenuates-inflammatory-responses-and-joint-damage-in-collagen-induced-arthritis
#8
Yunxia Tao, Zhirong Wang, Liangliang Wang, Jiawei Shi, Xiaobin Guo, Wei Zhou, Xiexing Wu, Yu Liu, Wen Zhang, Huilin Yang, Qin Shi, Yaozeng Xu, Dechun Geng
Objective: miRNAs are small, signal-strand, non-coding RNAs that function in post-transcriptional regulation. We analysed the in vivo effect of miR-106b (miR-106b-5p) on inflammatory bone loss in CIA mice. Methods: CIA mice are developed by injecting DAB/1 mice with bovine type II collagen containing Freund's adjuvant and then the in vivo effect of miR-106b is examined. On day 22, mice were given lentiviral negative control, lentiviral-mediated miR-106b mimics or lentiviral-mediated miR-106b inhibitor via orbital injection on a weekly basis...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28930753/camel-milk-attenuates-rheumatoid-arthritis-via-inhibition-of-mitogen-activated-protein-kinase-pathway
#9
Hany H Arab, Samir A Salama, Tamer M Abdelghany, Hany A Omar, El-Shaimaa A Arafa, Majed M Alrobaian, Ibrahim A Maghrabi
BACKGROUND/AIMS: Camel milk (CM) has shown beneficial anti-inflammatory actions in several experimental and clinical settings. So far, its effect on rheumatoid arthritis (RA) has not been previously explored. Thus, the current work aimed to evaluate the effects of CM in Adjuvant-induced arthritis and air pouch edema models in rats, which mimic human RA. METHODS: CM was administered at 10 ml/kg orally for 3 weeks starting on the day of Freund's adjuvant paw inoculation...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28887857/development-of-a-patient-specific-atrial-phantom-model-for-planning-and-training-of-inter-atrial-interventions
#10
Pedro Morais, João Manuel R S Tavares, Sandro Queirós, Fernando Veloso, Jan D'hooge, João L Vilaça
BACKGROUND: Several authors have presented cardiac phantoms to mimic the particularities of the heart, making it suitable for medical training and surgical planning. Although the initial models were mainly focused on the ventricles, personalized phantoms of the atria were recently presented. However, such models are typically rigid, the atrial wall is not realistic and they are not compatible with ultrasound (US), being sub-optimal for planning/training of several interventions. METHODS: In this work, we propose a strategy to construct a patient-specific atrial model...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28840350/regulatory-t-cells-and-il-10-as-modulators-of-chikungunya-disease-outcome-a-preliminary-study
#11
S P Kulkarni, M Ganu, P Jayawant, S Thanapati, A Ganu, A S Tripathy
Regulatory T (Treg) cells hold centre stage in regulating the immune responses in most viral infections. However, their involvement in chikungunya infection is unexplored. In the current study, the frequencies and functionality of peripheral Treg and T effector (Teff) cells were assessed during different phases of chikungunya by flow cytometry and in-vitro cytokine assays. Treg cells were also studied in rheumatoid arthritis (RA) patients, whose symptoms closely mimic chronic chikungunya arthritis patients...
December 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28807007/tnf-%C3%AE-induced-mir-155-regulates-il-6-signaling-in-rheumatoid-synovial-fibroblasts
#12
Kiyoshi Migita, Nozomi Iwanaga, Yasumori Izumi, Chieko Kawahara, Kenji Kumagai, Tadashi Nakamura, Tomohiro Koga, Atsushi Kawakami
BACKGROUND: MicroRNAs (miRNAs) are important regulators of a variety of inflammatory mediators. The present study was undertaken to elucidate the role of miRNAs in the rheumatoid cytokine network. METHODS: We analyzed miRNA expression in rheumatoid synovial fibroblasts (RASFs). miRNA array-based screening was used to identify miRNAs differentially expressed between tumor necrosis factor-α (TNF-α)-activated RASFs and untreated RASFs. Transfection of RASFs with miR-155 was used to analyze the function of miR-155...
August 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28782180/down-regulation-of-mir-10a-5p-in-synoviocytes-contributes-to-tbx5-controlled-joint-inflammation
#13
Nazim Hussain, Wenhua Zhu, Congshan Jiang, Jing Xu, Xiaoying Wu, Manman Geng, Safdar Hussain, Yongsong Cai, Ke Xu, Peng Xu, Yan Han, Jian Sun, Liesu Meng, Shemin Lu
MicroRNAs are considered to play critical roles in the pathogenesis of human inflammatory arthritis, including rheumatoid arthritis (RA). The purpose of this study was to determine the relationship between miR-10a-5p and TBX5 in synoviocytes and evaluate their contribution to joint inflammation. The expression of miR-10a-5p and TBX5 in the synovium of RA and human synovial sarcoma cell line SW982 stimulated by IL-1β was determined by RT-qPCR and Western blotting. The direct interaction between miR-10a-5p and TBX5 3'UTR was determined by dual-luciferase reporter assay in HeLa cells...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28742830/regulatory-effects-of-zinc-on-cadmium-induced-cytotoxicity-in-chronic-inflammation
#14
Paola Bonaventura, Aline Lamboux, Francis Albarède, Pierre Miossec
OBJECTIVES: Zinc (Zn) has major effects on immune system activation while Cadmium (Cd) has anti-inflammatory and anti-proliferative effects in several chronic inflammatory contexts. The aim of this work was to investigate by which mechanisms Zn could compete with Cd and eventually counteract its deleterious effects. Rheumatoid arthritis (RA) synoviocytes exposed to cytokines were used as a model of chronic inflammation; osteoarthritis (OA) synoviocytes were used as control. METHODS: Cell/medium fractionation constants were analyzed for different metals by inductively-coupled-plasma mass-spectrometry by comparison to the 70Zn spike...
2017: PloS One
https://www.readbyqxmd.com/read/28738524/elevated-microrna-125b-promotes-inflammation-in-rheumatoid-arthritis-by-activation-of-nf-%C3%AE%C2%BAb-pathway
#15
Bo Zhang, Li-Song Wang, Yu-Hu Zhou
microRNA-125b (miR-125b) has been reported to be increased in rheumatoid arthritis (RA). However, the role of miR-125b in RA remains to be fully elucidated. We aimed to explore the functional role of miR-125b in RA, as well as the underlying mechanism. The expression of miR-125b in serum and synovial tissues of patients with RA and healthy controls was confirmed. In addition, the levels of miR-125b in lipopolysaccharide (LPS)-stimulated fibroblast-like synoviocytes (FLS) were also measured. FLS were transfected with miR-125b mimic, antisense oligonucleotides (ASO)-miR-125b, pcDNA-inhibitor of NF-κB (IκB)-α or corresponding controls, and then stimulated with LPS or incubated with nuclear factor kappa B (NF-κB) inhibitors pyrrolidine dithiocarbamate (PDTC)...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28690010/tailoring-surface-nanoroughness-of-electrospun-scaffolds-for-skeletal-tissue-engineering
#16
Honglin Chen, Xiaobin Huang, Minmin Zhang, Febriyani Damanik, Matthew B Baker, Anne Leferink, Huipin Yuan, Roman Truckenmüller, Clemens van Blitterswijk, Lorenzo Moroni
Electrospun scaffolds provide a promising approach for tissue engineering as they mimic the physical properties of extracellular matrix. Previous studies have demonstrated that electrospun scaffolds with porous features on the surface of single fibers, enhanced cellular attachment and proliferation. Yet, little is known about the effect of such topographical cues on cellular differentiation. Here, we aimed at investigating the influence of surface roughness of electrospun scaffolds on skeletal differentiation of human mesenchymal stromal cells (hMSCs)...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28645663/failure-torque-of-ceramic-neck-titanium-implant
#17
Waleed Elshahawy, Raed Ajlouni, Khaldoun Ajlouni, Abdelfattah Sadakah
STATEMENT OF PROBLEM: Dental implants are typically made of titanium. However, with the current systems on the market, the implant neck often shows through the gingival tissues as a black or dark gray line and/or as a grayish discoloration of the peri-implant soft tissue. PURPOSE: The purpose of this in vitro study was to test a new implant design. The key component of this design is the ceramic shell that covers the polished collar of the tissue-level titanium implant and masks its dark color to mimic natural dentition...
June 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28584055/prolonged-fasting-suppresses-mitochondrial-nlrp3-inflammasome-assembly-and-activation-via-sirt3-mediated-activation-of-superoxide-dismutase-2
#18
COMPARATIVE STUDY
Javier Traba, Sarah S Geiger, Miriam Kwarteng-Siaw, Kim Han, One Hyuk Ra, Richard M Siegel, David Gius, Michael N Sack
Twenty-four hours of fasting is known to blunt activation of the human NLRP3 inflammasome. This effect might be mediated by SIRT3 activation, controlling mitochondrial reactive oxygen species. To characterize the molecular underpinnings of this fasting effect, we comparatively analyzed the NLRP3 inflammasome response to nutrient deprivation in wild-type and SIRT3 knock-out mice. Consistent with previous findings for human NLRP3, prolonged fasting blunted the inflammasome in wild-type mice but not in SIRT3 knock-out mice...
July 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28549217/surface-enhanced-raman-scattering-active-gold-nanoparticles-with-enzyme-mimicking-activities-for-measuring-glucose-and-lactate-in-living-tissues
#19
Yihui Hu, Hanjun Cheng, Xiaozhi Zhao, Jiangjiexing Wu, Faheem Muhammad, Shichao Lin, Jian He, Liqi Zhou, Chengping Zhang, Yu Deng, Peng Wang, Zhengyang Zhou, Shuming Nie, Hui Wei
Gold nanoparticles (AuNPs) with simultaneous plasmonic and biocatalytic properties provide a promising approach to developing versatile bioassays. However, the combination of AuNPs' intrinsic enzyme-mimicking properties with their surface-enhanced Raman scattering (SERS) activities has yet to be explored. Here we designed a peroxidase-mimicking nanozyme by in situ growing AuNPs into a highly porous and thermally stable metal-organic framework called MIL-101. The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG...
June 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28545554/whipple-s-disease-mimicking-rheumatoid-arthritis-can-cause-misdiagnosis-and-treatment-failure
#20
Cornelia Glaser, Siegbert Rieg, Thorsten Wiech, Christine Scholz, Dominique Endres, Oliver Stich, Peter Hasselblatt, Walter Geißdörfer, Christian Bogdan, Annerose Serr, Georg Häcker, Reinhard E Voll, Jens Thiel, Nils Venhoff
BACKGROUND: Whipple's disease, a rare chronic infectious disorder caused by Tropheryma whipplei, may present with predominant joint manifestations mimicking rheumatoid arthritis (RA). METHODS: A retrospective single-center cohort study of seven patients was performed. Clinical symptoms were assessed by review of medical charts and Whipple's disease was diagnosed by periodic-acid-Schiff-stain and/or Tropheryma whipplei-specific polymerase-chain-reaction. RESULTS: Median age at disease onset was 54 years, six patients were male...
May 25, 2017: Orphanet Journal of Rare Diseases
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