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https://www.readbyqxmd.com/read/29785875/egfr-tkis-in-non-small-cell-lung-cancer-focus-on-clinical-pharmacology-and-mechanisms-of-resistance
#1
Stefano Fogli, Beatrice Polini, Marzia Del Re, Iacopo Petrini, Antonio Passaro, Stefania Crucitta, Eleonora Rofi, Romano Danesi
The clinical introduction of EGFR-TKIs within the oncologic armamentarium has changed the therapeutic landscape of non-small-cell lung cancer (NSCLC) creating widespread expectations both in patients and clinicians. However, several gaps in current understanding leave open important questions regarding the use of these drugs in clinical practice. For instance, there is uncertainty in regard to which EGFR-TKI should be given first in naive patients with EGFR-driven malignancies since different generations of drugs are available with different pharmacological profiles...
May 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29782168/rapid-aqueous-phase-hydrolysis-of-ester-hydroperoxides-arising-from-criegee-intermediates-and-organic-acids
#2
Ran Zhao, Christopher M Kenseth, Yuanlong Huang, Nathan F Dalleska, Xiaobi Michelle Kuang, Jierou Chen, Suzanne E Paulson, John H Seinfeld
Stabilized Criegee intermediates react with organic acids in the gas phase and at the air-water interface to form a class of ester hydroperoxides, α-acyloxyalkyl hydroperoxides (αAAHPs). A number of recent studies have proposed the importance of αAAHPs to the formation and growth of secondary organic aerosol (SOA). The chemistry of αAAHPs has not been investigated due to a lack of commercially available chemical standards. In this work, the behavior of αAAHPs in condensed phases is investigated for the first time...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29780328/contractile-activity-is-necessary-to-trigger-intermittent-hypobaric-hypoxia-induced-fiber-size-and-vascular-adaptations-in-skeletal-muscle
#3
David Rizo-Roca, Jèssica B Bonet, Büsra Ínal, Juan Gabriel Ríos-Kristjánsson, Teresa Pagès, Ginés Viscor, Joan R Torrella
Altitude training has become increasingly popular in recent decades. Its central and peripheral effects are well-described; however, few studies have analyzed the effects of intermittent hypobaric hypoxia (IHH) alone on skeletal muscle morphofunctionality. Here, we studied the effects of IHH on different myofiber morphofunctional parameters, investigating whether contractile activity is required to elicit hypoxia-induced adaptations in trained rats. Eighteen male Sprague-Dawley rats were trained 1 month and then divided into three groups: (1) rats in normobaria (trained normobaric inactive, TNI); (2) rats subjected daily to a 4-h exposure to hypobaric hypoxia equivalent to 4,000 m (trained hypobaric inactive, THI); and (3) rats subjected daily to a 4-h exposure to hypobaric hypoxia just before performing light exercise (trained hypobaric active, THA)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29773512/increased-foot-strike-variability-in-parkinson-s-disease-patients-with-freezing-of-gait
#4
Jesal Shah, Lakshmi Pillai, David K Williams, Shannon M Doerhoff, Linda Larson-Prior, Edgar Garcia-Rill, Tuhin Virmani
INTRODUCTION: Freezing of gait (FOG) is a debilitating, late motor complication of Parkinson's disease (PD) that occurs in 50-80% of patients. Gait freezing significantly worsens quality of life by decreasing mobility and increasing falls. Studies have shown that patients with episodic freezing episodes also have deficits in continuous gait. We evaluated whether there was an objective gait correlate to the increased stumbling reported by many patients with gait freezing. METHODS: PD subjects and healthy controls (HC) were enrolled after IRB approval...
May 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29772840/secure-data-access-control-for-fog-computing-based-on-multi-authority-attribute-based-signcryption-with-computation-outsourcing-and-attribute-revocation
#5
Qian Xu, Chengxiang Tan, Zhijie Fan, Wenye Zhu, Ya Xiao, Fujia Cheng
Nowadays, fog computing provides computation, storage, and application services to end users in the Internet of Things. One of the major concerns in fog computing systems is how fine-grained access control can be imposed. As a logical combination of attribute-based encryption and attribute-based signature, Attribute-based Signcryption (ABSC) can provide confidentiality and anonymous authentication for sensitive data and is more efficient than traditional "encrypt-then-sign" or "sign-then-encrypt" strategy...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29772645/anticancer-activity-of-euplotin-c-isolated-from-the-marine-ciliate-euplotes-crassus-against-human-melanoma-cells
#6
Sara Carpi, Beatrice Polini, Giulio Poli, Gabriela Alcantara Barata, Stefano Fogli, Antonella Romanini, Tiziano Tuccinardi, Graziano Guella, Francesco Paolo Frontini, Paola Nieri, Graziano Di Giuseppe
Cutaneous melanoma is the most serious type of skin cancer, so new cytotoxic weapons against novel targets in melanoma are of great interest. Euplotin C (EC), a cytotoxic secondary metabolite of the marine ciliate Euplotes crassus , was evaluated in the present study on human cutaneous melanoma cells to explore its anti-melanoma activity and to gain more insight into its mechanism of action. EC exerted a marked cytotoxic effect against three different human melanoma cell lines (A375, 501Mel and MeWo) with a potency about 30-fold higher than that observed in non-cancer cells (HDFa cells)...
May 16, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29770861/the-fate-of-fogli-s-lore-s-fascial-platysma-fixation-optimalising-the-results-of-fogli-s-neck-lift-procedure
#7
Darryl J Hodgkinson
The author has modified previously described techniques of the superior suspension of the platysma muscle to Lore's fascia by developing an auriculoplastysmal fascial flap, which detaches the posterior platysma from its retaining ligaments to the sternomastoid muscle. Anterior to this flap, the platysma muscle is undermined and suture captured with three throws of a permanent 2.0 Tevdek suture. This suture and its three throws are fixed anterior to the tragus, which includes Lore's fascia and on tightening elevates the whole of the anterior neck as well as defines the cervicomental angle...
May 16, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29757988/a-lightweight-protocol-for-secure-video-streaming
#8
Algimantas Venčkauskas, Nerijus Morkevicius, Kazimieras Bagdonas, Robertas Damaševičius, Rytis Maskeliūnas
The Internet of Things (IoT) introduces many new challenges which cannot be solved using traditional cloud and host computing models. A new architecture known as fog computing is emerging to address these technological and security gaps. Traditional security paradigms focused on providing perimeter-based protections and client/server point to point protocols (e.g., Transport Layer Security (TLS)) are no longer the best choices for addressing new security challenges in fog computing end devices, where energy and computational resources are limited...
May 14, 2018: Sensors
https://www.readbyqxmd.com/read/29757227/combining-fog-computing-with-sensor-mote-machine-learning-for-industrial-iot
#9
Mehrzad Lavassani, Stefan Forsström, Ulf Jennehag, Tingting Zhang
Digitalization is a global trend becoming ever more important to our connected and sustainable society. This trend also affects industry where the Industrial Internet of Things is an important part, and there is a need to conserve spectrum as well as energy when communicating data to a fog or cloud back-end system. In this paper we investigate the benefits of fog computing by proposing a novel distributed learning model on the sensor device and simulating the data stream in the fog, instead of transmitting all raw sensor values to the cloud back-end...
May 12, 2018: Sensors
https://www.readbyqxmd.com/read/29753556/pharmacotherapy-for-postural-tachycardia-syndrome
#10
REVIEW
Amanda J Miller, Satish R Raj
Postural tachycardia syndrome (POTS) is a disorder characterized by the presence of orthostatic symptoms (including lightheadedness, palpitations, nausea, dyspnea, and tremulousness) as well as excessive upright tachycardia. POTS predominantly affects women of childbearing age. Treating POTS involves a multi-faceted approach using non-pharmacological and pharmacological interventions. There are no pharmacological treatments that are currently United States Food and Drug Administration (FDA) approved for POTS due to lack of randomized controlled trials...
May 4, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29738079/patients-with-chronic-fatigue-syndrome-do-not-score-higher-on-the-autism-spectrum-quotient-than-healthy-controls-comparison-with-autism-spectrum-disorder
#11
Indre Bileviciute-Ljungar, Daniel Maroti, Susanne Bejerot
Clinically, there is an overlap of several symptoms of chronic fatigue syndrome (CFS) and autism spectrum disorder (ASD), including fatigue; brain "fog"; cognitive impairments; increased sensitivity to sound, light, and odour; increased pain and tenderness; and impaired emotional contact. Adults with CFS (n = 59) or ASD (n = 50) and healthy controls (HC; n = 53) were assessed with the Autism-Spectrum Quotient (AQ) in a cross-sectional study. Non-parametric analysis was used to compare AQ scores among the groups...
May 8, 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29731302/quantitative-control-of-gpcr-organization-and-signaling-by-endocytosis-in-epithelial-morphogenesis
#12
Ankita Jha, Thomas S van Zanten, Jean-Marc Philippe, Satyajit Mayor, Thomas Lecuit
Tissue morphogenesis arises from controlled cell deformations in response to cellular contractility. During Drosophila gastrulation, apical activation of the actomyosin networks drives apical constriction in the invaginating mesoderm and cell-cell intercalation in the extending ectoderm. Myosin II (MyoII) is activated by cell-surface G protein-coupled receptors (GPCRs), such as Smog and Mist, that activate G proteins, the small GTPase Rho1, and the kinase Rok. Quantitative control over GPCR and Rho1 activation underlies differences in deformation of mesoderm and ectoderm cells...
April 25, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29715662/antimicrobial-effect-of-different-peroxyacetic-acid-and-hydrogen-peroxide-formats-against-spores-of-clostridium-estertheticum
#13
John Mills, Kylie Marree Horváth, Gale Brightwell
"Blown pack" spoilage is primarily caused by Clostridium estertheticum. The primary source of contamination is probably pelts, faeces and soil during opening cuts and de-hiding. Peroxyacetic acid (POAA) based fogs are commonly included in an abattoir's routine cleaning process. Hydrogen peroxide (H2 O2 ) is a powerful oxidizing agent that penetrates microbe cell walls causing cell death. In this study, we compared the ability of H2 O2 and OXYSAN ZS (POAA containing 1-hydroxyethylidine-1,1-diphosphonic acid as a stabilizer) in different formats to inactivate C...
April 23, 2018: Meat Science
https://www.readbyqxmd.com/read/29708870/validation-of-freezing-of-gait-monitoring-using-smartphone
#14
Han Byul Kim, Hong Ji Lee, Woong Woo Lee, Sang Kyong Kim, Hyo Seon Jeon, Hye Young Park, Chae Won Shin, Won Jin Yi, Beomseok Jeon, Kwang S Park
BACKGROUND: Freezing of gait (FOG) is a commonly observed motor symptom for patients with Parkinson's disease (PD). The symptoms of FOG include reduced step lengths or motor blocks, even with an evident intention of walking. FOG should be monitored carefully because it not only lowers the patient's quality of life, but also significantly increases the risk of injury. INTRODUCTION: In previous studies, patients had to wear several sensors on the body and another computing device was needed to run the FOG detection algorithm...
April 30, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29705593/understanding-how-surface-chemistry-and-topography-enhance-fog-harvesting-based-on-the-superwetting-surface-with-patterned-hemispherical-bulges
#15
Lieshuang Zhong, Hai Zhu, Yang Wu, Zhiguang Guo
The Namib Desert beetle-Stenocara can adapt to the arid environment by its fog harvesting ability. A series of samples with different topography and wettability that mimicked the elytra of the beetle were fabricated to study the effect of these factors on fog harvesting. The superhydrophobic bulgy sample harvested 1.5 times the amount of water than the sample with combinational pattern of hydrophilic bulgy/superhydrophobic surrounding and 2.83 times than the superhydrophobic surface without bulge. These bulges focused the droplets around them which endowed droplets with higher velocity and induced the highest dynamic pressure atop them...
April 23, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29696615/influence-of-cognitive-impairment-on-the-freezing-of-gait-in-non-demented-people-with-parkinson-s-disease
#16
J M Cancela, C M Nascimento, S Varela, M Seijo-Martinez, L Lorenzo-Lopez, J C Millan-Calenti, C Dominguez-Vivero, C Ayan
INTRODUCTION: Freezing of gait (FOG) is a motor disturbance usually appearing in advanced Parkinson's disease (PD). Cognitive and executive function seems to play an important role in this phenomenon. AIM: To investigate if cognitive and kinematic parameters correlate with FOG in PD patients without dementia. PATIENTS AND METHODS: We conducted an observational cross-sectional study. Participants were classified in two groups: freezers and non-freezers...
May 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29688288/the-fog-may-be-lifting-around-antibiotic-use-metrics-and-inter-facility-comparison
#17
Scott K Fridkin
No abstract text is available yet for this article.
April 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29687971/indication-and-treatment-strategies-in-aortic-dissection-the-fog-is-rising
#18
Konstantinos Spanos, Tilo Kölbel
No abstract text is available yet for this article.
April 24, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29687398/-twisting-fingers-the-case-for-interactivity-in-typed-language-production
#19
Svetlana Pinet, Nazbanou Nozari
Despite the obvious linguistic nature of typing, current psychological models of typing are, to a large extent, divorced from models of spoken language production. This gap has left unanswered many questions regarding the cognitive architecture of typing. In this article we advocate the use of a psycholinguistic framework for studying typing, by showing that such a framework could reveal important similarities and differences between spoken and typed production. Specifically, we investigated the interaction between the lexical and postlexical layers by using a phenomenon known in spoken production as the "repeated-phoneme effect...
April 23, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29682581/diet-induced-abdominal-obesity-metabolic-changes-and-atherosclerosis-in-hypercholesterolemic-minipigs
#20
Ahmed Ludvigsen Al-Mashhadi, Christian Bo Poulsen, Karin von Wachenfeldt, Anna-Karin Robertson, Jacob Fog Bentzon, Lars Bo Nielsen, Jesper Thygesen, Lars Poulsen Tolbod, Jens Rolighed Larsen, Søren Kragh Moestrup, Björn Frendéus, Brynjulf Mortensen, Ludovic Drouet, Rozh H Al-Mashhadi, Erling Falk
Background: Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive. Animal models resembling human MetS and its complications, while important, are scarce. We aimed at developing a porcine model of human MetS. Methods: Forty pigs with familial hypercholesterolemia were fed a high fat + fructose diet for 30 weeks. Metabolic assessments and subcutaneous fat biopsies were obtained at 18 and 30 weeks, and fat distribution was assessed by CT-scans...
2018: Journal of Diabetes Research
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