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https://www.readbyqxmd.com/read/28106569/cerebellar-volume-and-executive-function-in-parkinson-disease-with-and-without-freezing-of-gait
#1
Peter S Myers, Marie E McNeely, Jonathan M Koller, Gammon M Earhart, Meghan C Campbell
BACKGROUND: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. OBJECTIVE: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-)...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28100882/efficient-fractionation-and-analysis-of-fatty-acids-and-their-salts-in-fat-oil-and-grease-fog-deposits
#2
Herman P Benecke, Sara K Allen, Daniel B Garbark
A fractionation methodology of fat, oil and grease (FOG) deposits was developed based on the insolubility of fatty acid salts in dichloromethane (DCM) and the relatively high solubility of fatty acids and triglycerides in DCM. Using this method, coupled with spectral analysis, it was shown that fatty acids rather than fatty acid salts were the predominant species in FOG deposits obtained from three metropolitan locations in the United States and that fatty acid triglycerides were either not detected or were present in very small concentrations...
January 18, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28095387/mri-of-cerebellar-infarction
#3
Laurens J L De Cocker, Karl-Olof Lövblad, Jeroen Hendrikse
BACKGROUND: MRI is the imaging modality of choice for diagnosing brain infarction. Because of few or atypical clinical symptoms and a relatively low sensitivity of CT scans, many cerebellar infarctions may be detected only with MRI. With adequate recognition of cerebellar infarction on MRI and prompt initiation or optimisation of preventive therapeutic measures, more dramatic strokes may be avoided in selected cases. SUMMARY: We first briefly review the clinical presentation of cerebellar infarctions, followed by a short refresher on cerebellar anatomy and pathophysiological mechanisms of cerebellar infarcts...
January 18, 2017: European Neurology
https://www.readbyqxmd.com/read/28089518/transcriptional-pre-patterning-of-drosophila-gastrulation
#4
Bomyi Lim, Michael Levine, Yuji Yamakazi
Gastrulation of the Drosophila embryo is one of the most intensively studied morphogenetic processes in animal development [1-4]. Particular efforts have focused on the formation of the ventral furrow, whereby ∼1,000 presumptive mesoderm cells exhibit coordinated apical constrictions that mediate invagination [5, 6]. Apical constriction depends on a Rho GTPase signaling pathway (T48/Fog) that is deployed by the developmental regulatory genes twist and snail [7-10]. It is thought that coordinate mesoderm constriction depends on high levels of myosin along the ventral midline, although the basis for this localization is uncertain...
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28075157/visual-occlusion-during-minimally-invasive-surgery-a-contemporary-review-of-methods-to-reduce-laparoscopic-and-robotic-lens-fogging-and-other-sources-of-optical-loss
#5
Todd Galvin Manning, Marlon Perera, Daniel Christidis, Ned Kinnear, Shannon McGrath, Richard O'Beirne, Paul Zotov, Damien M Bolton, Nathan Lawrentschuk
Background Maintenance of optimal vision during minimally invasive surgery is crucial to maintaining operative awareness, efficiency and safety. Hampered vision is commonly caused by laparoscopic lens fogging (LLF) which has prompted the development of various anti-fogging fluids and warming devices. However, limited comparative evidence exists in contemporary literature. Despite technological advancements there remains no consensus as to superior methods to prevent LLF or restore visual acuity once LLF has occurred...
January 11, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28067828/pharmacogenetic-foundations-of-therapeutic-efficacy-and-adverse-events-of-statins
#6
REVIEW
Elena Arrigoni, Marzia Del Re, Leonardo Fidilio, Stefano Fogli, Romano Danesi, Antonello Di Paolo
BACKGROUND: In the era of precision medicine, more attention is paid to the search for predictive markers of treatment efficacy and tolerability. Statins are one of the classes of drugs that could benefit from this approach because of their wide use and their incidence of adverse events. METHODS: Literature from PubMed databases and bibliography from retrieved publications have been analyzed according to terms such as statins, pharmacogenetics, epigenetics, toxicity and drug-drug interaction, among others...
January 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28066819/growth-on-chitin-impacts-the-transcriptome-and-metabolite-profiles-of-antibiotic-producing-vibrio-coralliilyticus-s2052-and-photobacterium-galatheae-s2753
#7
Sonia Giubergia, Christopher Phippen, Kristian Fog Nielsen, Lone Gram
Members of the Vibrionaceae family are often associated with chitin-containing organisms, and they are thought to play a major role in chitin degradation. The purpose of the present study was to determine how chitin affects the transcriptome and metabolome of two bioactive Vibrionaceae strains, Vibrio coralliilyticus and Photobacterium galatheae. We focused on chitin degradation genes and secondary metabolites based on the assumption that these molecules in nature confer an advantage to the producer. Growth on chitin caused upregulation of genes related to chitin metabolism and of genes potentially involved in host colonization and/or infection...
January 2017: MSystems
https://www.readbyqxmd.com/read/28064277/smad2-phosphorylation-in-diabetic-kidney-tubule-epithelial-cells-is-associated-with-modulation-of-several-transforming-growth-factor-%C3%AE-family-members
#8
Lise Høj Thomsen, Morten Fog-Tonnesen, Lisbeth Nielsen Fink, Jenny Norlin, Amaya García de Vinuesa, Troels Krarup Hansen, Emile de Heer, Peter Ten Dijke, Alexander Rosendahl
BACKGROUND: The role of transforming growth factor-β (TGF-β) has recently gained much attention in diabetic nephropathy and kidney fibrosis. In this study, we extend this to an assessment of transcriptional regulation of the entire TGF-β superfamily in kidneys from diabetic vs. healthy mice. In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-β/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients...
January 7, 2017: Nephron
https://www.readbyqxmd.com/read/28048273/su-f-i-70-investigation-of-gafchromic-ebt3-film-energy-dependence-using-proton-photon-and-electron-beams
#9
C Ferreira, E Schnell, S Ahmad, T De La Fuente Herman
PURPOSE: To investigate the energy dependence of Gafchromic EBT3 film over a range of clinically used proton, photon and electron energies. METHODS: Proton beam energies of 117 and 204 MeV, corresponding respectively to ranges in water of 10 cm and 27 cm from a Mevion S250 double scatter system unit were used. Electron energies of 6 and 20 MeV and photon energies of 6 and 18 MV from a Varian Clinac 21EX Linac were used. Two pieces of film (5×5 cm(2) ) were irradiated sequentially for doses of 100, 500, and 1000 cGy for all energies and modalities...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045633/readability-trends-of-online-information-by-the-american-academy-of-otolaryngology-head-and-neck-surgery-foundation
#10
Kevin Wong, Jessica R Levi
Objective Previous studies have shown that patient education materials published by the American Academy of Otolaryngology-Head and Neck Surgery Foundation may be too difficult for the average reader to understand. The purpose of this study was to determine if current educational materials show improvements in readability. Study Design Cross-sectional analysis. Setting The Patient Health Information section of the American Academy of Otolaryngology-Head and Neck Surgery Foundation website. Subjects and Methods All patient education articles were extracted in plain text...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28035673/somatic-and-neuritic-spines-on-tyrosine-hydroxylase-immunopositive-cells-of-rat-retina
#11
Anna Fasoli, James Dang, Aaron H Gouw, Jeffrey S Johnson, Alex Fogli Iseppe, Andrew T Ishida
Dopamine- and tyrosine hydroxylase-immunopositive cells (TH cells) modulate visually driven signals as they flow through retinal photoreceptor, bipolar, and ganglion cells. Previous studies suggested that TH cells release dopamine from varicose axons arborizing in the inner and outer plexiform layers after glutamatergic synapses depolarize TH cell dendrites in the inner plexiform layer and these depolarizations propagate to the varicosities. Although it has been proposed that these excitatory synapses are formed onto appendages resembling dendritic spines, spines have not been found on TH cells of most species examined to date or on TH cell somata which release dopamine when exposed to glutamate receptor agonists...
December 30, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28030927/fogging-low-concentrated-organic-acid-in-a-fattening-pig-unit-effect-on-animal-health-and-microclimate
#12
Heiko Stein, Jochen Schulz, Nicole Kemper, Alexander Tichy, Ines Krauss, Christian Knecht, Isabel Hennig-Pauka
INTRODUCTION AND OBJECTIVE: In intensive pig production aerial contaminates are potential hazards for the health of animals and humans. In this study, the effect of fogging a low concentrated tartaric acid solution on pigs' health, environmental and hygiene parameters were evaluated in an inhabited fattening unit. MATERIALS AND METHOD: Pigs were housed in separate units (control group n=109 and experimental group n=110). During the whole fattening period, twice a week at 48 hour intervals, a 0...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28028412/the-role-of-the-velopharyngeal-sphincter-in-the-speech-of-patients-with-cleft-palate-or-cleft-lip-and-palate-using-perceptual-methods
#13
Tatjana Georgievska-Jancheska, Juliana Gjorgova, Mirjana Popovska
BACKGROUND: The velopharyngeal sphincter (VPS) plays the main role in speech formation. The cleft palate, due to the damage of the soft palate, leads to dysfunction of the velopharyngeal sphincter thus causing speech disorder. AIM: To establish a link between the nasal air escape and the perceptual symptoms in the speech of patients with cleft palate or cleft lip and palate using auditory-visual perceptual procedures for determining the influence the velopharyngeal dysfunction has on speech...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28026769/haze-removal-using-the-difference-structure-preservation-prior
#14
Linyuan He, Jizhong Zhao, Nanning Zheng, Duyan Bi
Fog cover is generally present in outdoor scenes, which limits the potential for efficient information extraction from images. In this paper, the goal of the developed algorithm is to obtain an optimal transmission map as well as to remove hazes from a single input image. To solve the problem, we meticulously analyze the optical model and recast the initial transmission map under an additional boundary prior. For better preservation of the results, the difference-structure-preservation dictionary could be learned such that the local consistency features of the transmission map could be well preserved after coefficient shrinkage...
December 22, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28024340/superhydrophobic-cones-for-continuous-collection-and-directional-transportation-of-co2-microbubbles-in-co2-supersaturated-solutions
#15
Xiuzhan Xue, Cunming Yu, Jingming Wang, Lei Jiang
Microbubbles are tiny bubbles with diameters below 50 μm. Because of their minute buoyant force, the microbubbles stagnate in aqueous media for a long time, and they sometimes cause serious damage. Most traditional methods chosen for elimination of gas bubbles utilize buoyancy forces including chemical methods and physical methods, and they only have a minor effect on microbubbles. Several approaches have been developed to collect and transport microbubbles in aqueous media. However, the realization of innovative strategies to directly collect and transport microbubbles in aqueous media remains a big challenge...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27982472/a-switchable-cross-species-liquid-repellent-surface
#16
Yu Huang, Birgitt Boschitsch Stogin, Nan Sun, Jing Wang, Shikuan Yang, Tak-Sing Wong
A switchable cross-species liquid-repellent surface is developed that can rapidly switch between two distinct liquid-repellent modes: (1) the superhydrophobic mode, modeled after lotus leaves, and (2) the slippery mode, modeled after the pitcher plant peristome. Adaptive liquid repellency and programmable fog harvesting have been demonstrated as application examples for the new switchable surface.
December 16, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27980878/glaucoma-and-driving-risk-under-simulated-fog-conditions
#17
Alberto Diniz-Filho, Erwin R Boer, Ahmed Elhosseiny, Zhichao Wu, Masaki Nakanishi, Felipe A Medeiros
PURPOSE: We evaluate driving risk under simulated fog conditions in glaucoma and healthy subjects. METHODS: This cross-sectional study included 41 glaucoma patients and 25 age-matched healthy subjects who underwent driving simulation. Tests consisted of curve negotiation without and with fog preview at 30 m of distance and two controlled speeds (slow and fast). Inverse time-to-line crossing (invTLC) was used as metric to quantify risk; higher invTLC values indicating higher risk, as less time is available to avoid drifting out of the road...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27976310/chemodiversity-of-the-ladder-frame-prymnesin-polyethers-of-the-fish-killing-microalgal-prymnesium-parvum
#18
S A Rasmussen, S Meier, N Gedsted Andersen, H Blossom, J Øllgaard Duus, K Fog Nielsen, T Ostenfeld Larsen
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27973484/pseudo-random-bit-sequence-phase-modulation-for-reduced-errors-in-a-fiber-optic-gyroscope
#19
Jacob Chamoun, Michel J F Digonnet
Low noise and drift in a laser-driven fiber optic gyroscope (FOG) are demonstrated by interrogating the sensor with a low-coherence laser. The laser coherence was reduced by broadening its optical spectrum using an external electro-optic phase modulator driven by either a sinusoidal or a pseudo-random bit sequence (PRBS) waveform. The noise reduction measured in a FOG driven by a modulated laser agrees with the calculations based on the broadened laser spectrum. Using PRBS modulation, the linewidth of a laser was broadened from 10 MHz to more than 10 GHz, leading to a measured FOG noise of only 0...
December 15, 2016: Optics Letters
https://www.readbyqxmd.com/read/27956066/the-clinical-significance-of-freezing-while-turning-in-parkinson-s-disease
#20
Martina Mancini, Katrijn Smulders, Rajal G Cohen, Fay B Horak, Nir Giladi, John G Nutt
Freezing of gait (FoG) in people with Parkinson's disease (PD) is an environmentally sensitive, intermittent problem that occurs most often during turning. FoG is difficult for clinicians to evaluate and treat because it can be difficult to elicit during a clinical visit. Here, we aimed to develop a clinically valid objective measure of freezing severity during a 2-min 360-degree turning-in-place. Twenty-eight subjects with PD (16 freezers, FoG+, and 12 nonfreezers, FoG-) in the "off" state and 14 healthy control subjects were tested...
December 9, 2016: Neuroscience
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