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https://www.readbyqxmd.com/read/29150475/uptodate-adherence-to-grade-criteria-for-strong-recommendations-an-analytical-survey
#1
Thomas Agoritsas, Arnaud Merglen, Anja Fog Heen, Annette Kristiansen, Ignacio Neumann, Juan P Brito, Romina Brignardello-Petersen, Paul E Alexander, David M Rind, Per O Vandvik, Gordon H Guyatt
INTRODUCTION: UpToDate is widely used by clinicians worldwide and includes more than 9400 recommendations that apply the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. GRADE guidance warns against strong recommendations when certainty of the evidence is low or very low (discordant recommendations) but has identified five paradigmatic situations in which discordant recommendations may be justified. OBJECTIVES: Our objective was to document the strength of recommendations in UpToDate and assess the frequency and appropriateness of discordant recommendations...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149050/combining-a-disturbance-observer-with-triple-loop-control-based-on-mems-accelerometers-for-line-of-sight-stabilization
#2
Yong Luo, Yongmei Huang, Chao Deng, Yao Mao, Wei Ren, Qiongyan Wu
In the CCD-based fine tracking optical system (FTOS), the whole disturbance suppression ability (DSA) is the product of the inner loop and outer position loop. Traditionally, high sampling fiber-optic gyroscopes (FOGs) are added to the platform to stabilize the line-of-sight (LOS). However, because of the FOGs' high cost and relatively big volume relative to the back narrow space of small rotating mirrors, we attempt in this work to utilize a cheaper and smaller micro-electro-mechanical system (MEMS) accelerometer to build the inner loop, replacing the FOG...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29148136/effects-of-sensitive-electrical-stimulation-based-somatosensory-cueing-in-parkinson-s-disease-gait-and-freezing-of-gait-assessment
#3
Benoît Sijobert, Christine Azevedo, David Andreu, Claudia Verna, Christian Geny
This study aims to investigate the effect of a somatosensory cueing on gait disorders in subjects with Parkinson's disease (PD). After having performed stepping in place and timed up and go assessing tasks, 13 participants with PD were equipped with an electrical stimulator and an inertial measurement unit (IMU) located under the lateral malleolus on the sagittal plane. Electrodes were positioned under the arch of the foot and electrical stimulation (ES) parameters (five 500 µs/phase charge-balanced biphasic pulses delivered at 200 Hz, repeated four times at 10 Hz) adjusted to deliver a sensitive signal...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29141746/monitoring-and-control-of-aedes-albopictus-a-vector-of-zika-virus-near-residences-of-imported-zika-virus-patients-during-2016-in-south-korea
#4
Kyu-Sik Chang, Gi-Hun Kim, Young-Ran Ha, Eun Kyeong Jeong, Heung-Chul Kim, Terry A Klein, Seung Hwan Shin, Eun Jeung Kim, Seung Jegal, Se Jin Chung, Young-Ran Ju, Young Mee Jee
Zika virus (ZIKV) is an arthropod-borne virus mainly transmitted by Aedes species. A total of nine of the 16 imported ZIKV reported cases during the mosquito season in the Republic of Korea (ROK), following the return of local nationals from foreign ZIKV endemic countries, were surveyed for Aedes albopictus. Surveillance and vector control of Ae. albopictus, a potential vector of ZIKV, and related species are critical for reducing the potential for autochthonous transmission in the ROK. Surveillance and vector control were coordinated by Korean Centers for Disease Control & Prevention (KCDC) and conducted by local health authorities within 200 m of imported ZIKV patients' residences...
November 13, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29137057/readability-of-internet-sourced-patient-education-material-related-to-labour-analgesia
#5
Nilay Boztas, Dilek Omur, Sule Ozbılgın, Gözde Altuntas, Ersan Piskin, Sevda Ozkardesler, Volkan Hanci
We evaluated the readability of Internet-sourced patient education materials (PEMs) related to "labour analgesia." In addition to assessing the readability of websites, we aimed to compare commercial, personal, and academic websites.We used the most popular search engine (http://www.google.com) in our study. The first 100 websites in English that resulted from a search for the key words "labour analgesia" were scanned. Websites that were not in English, graphs, pictures, videos, tables, figures and list formats in the text, all punctuation, the number of words in the text is less than 100 words, feedback forms not related to education, (Uniform Resource Locator) URL websites, author information, references, legal disclaimers, and addresses and telephone numbers were excluded...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137009/brain-metabolism-in-patients-with-freezing-of-gait-after-hypoxic-ischemic-brain-injury-a-pilot-study
#6
Seo Yeon Yoon, Sang Chul Lee, Na Young Kim, Young-Sil An, Yong Wook Kim
Movement disorders are 1 of the long-term neurological complications that can occur after hypoxic-ischemic brain injury (HIBI). However, freezing of gait (FOG) after HIBI is rare. The aim of this study was to examine the brain metabolism of patients with FOG after HIBI using F-18 fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG PET).We consecutively enrolled 11 patients with FOG after HIBI. The patients' overall brain metabolism was measured by F-18 FDG PET, and we compared their regional brain metabolic activity with that from 15 healthy controls using a voxel-by-voxel-based statistical mapping analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29128929/freezing-of-gait-in-parkinson-s-disease-gray-and-white-matter-abnormalities
#7
Sara Pietracupa, Antonio Suppa, Neeraj Upadhyay, Costanza Giannì, Giovanni Grillea, Giorgio Leodori, Nicola Modugno, Francesca Di Biasio, Alessandro Zampogna, Claudio Colonnese, Alfredo Berardelli, Patrizia Pantano
Freezing of gait (FOG) is a disabling disorder that often affects Parkinson's disease (PD) patients in advanced stages of the disease. To study structural gray matter (GM) and white matter (WM) changes in PD patients with and without FOG, twenty-one PD patients with FOG (PD-FOG), 16 PD patients without FOG (PD-nFOG) and 19 healthy subjects (HS) underwent a standardized MRI protocol. For the gray matter evaluation, cortical volume (CV), cortical thickness (CTh), and surface area (SA) were analyzed using the FreeSurfer pipeline...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29128259/role-of-dysregulated-cytokine-signaling-and-bacterial-triggers-in-the-pathogenesis-of-cutaneous-t-cell-lymphoma
#8
Melania H Fanok, Amy Sun, Laura K Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, Charalampos Lazaris, Adriana Heguy, Mary E Laird, Mark S Sundrud, Cynthia Liu, Jeff Kutok, Rodrigo S Lacruz, Jo-Ann Latkowski, Iannis Aifantis, Niels Ødum, Kenneth B Hymes, Swati Goel, Sergei B Koralov
Cutaneous T cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The molecular and cellular etiology of this malignancy remains enigmatic and what role antigenic stimulation plays in the initiation and/or progression of the disease remains to be elucidated. Deep sequencing of the tumor genome revealed a highly heterogeneous landscape of genetic perturbations and transcriptome analysis of transformed T cells further highlighted the heterogeneity of this disease...
November 8, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29118415/demonstration-of-measuring-sea-fog-with-an-snspd-based-lidar-system
#9
Jiang Zhu, Yajun Chen, Labao Zhang, Xiaoqing Jia, Zhijun Feng, Ganhua Wu, Xiachao Yan, Jiquan Zhai, Yang Wu, Qi Chen, Xiaoying Zhou, Zhizhong Wang, Chi Zhang, Lin Kang, Jian Chen, Peiheng Wu
The monitor of sea fogs become more important with the rapid development of marine activities. Remote sensing through laser is an effective tool for monitoring sea fogs, but still challengeable for large distance. We demonstrated a Long-distance Lidar for sea fog with superconducting nanowire single-photon detector (SNSPD), which extended the ranging area to a 180-km diameter area. The system, which was verified by using a benchmark distance measurement of a known island, is applied to the Mie scattering weather prediction Lidar system...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117016/analyzing-the-readability-of-online-urogynecologic-patient-information
#10
J Ryan Stewart, Michael H Heit, Kate V Meriwether, Deslyn T Hobson, Sean L Francis
OBJECTIVE: We sought to describe the readability of Web sites arising from the most common Google search terms related to pelvic organ prolapse, bladder control, and bowel control. METHODS: Google was queried to capture the top 100 search results for the keywords in each disease group. For the top 20 results of each keyword, we analyzed the text for readability using 4 readability formulas: Dale-Chall, Gunning-Fog, Simple Measure of Gobbledygook (SMOG), and Flesch-Kincaid Grade Level...
November 7, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29114238/long-term-monitoring-gait-analysis-using-a-wearable-device-in-daily-lives-of-patients-with-parkinson-s-disease-the-efficacy-of-selegiline-hydrochloride-for-gait-disturbance
#11
Mutsumi Iijima, Hiroshi Mitoma, Shinichiro Uchiyama, Kazuo Kitagawa
Objective: The aim of this study was to assess quantitatively the gait disorders in the daily lives of patients with Parkinson's disease (PD) using with a newly developed portable gait rhythmogram (PGR), which has a trunk-mounted acceleration sensor and automatic gait-detection algorithm. Methods: Using the PGR, we recorded the daily walking profiles of 14 PD patients before and after the addition or increase in dose of an MAO-B inhibitor (selegiline, average dose: 4...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29112837/vertical-observation-and-analysis-on-rapid-formation-and-evolutionary-mechanisms-of-a-prolonged-haze-episode-over-central-eastern-china
#12
Su-Qin Han, Tian-Yi Hao, Yu-Fen Zhang, Jing-le Liu, Pei-Yan Li, Zi-Ying Cai, Min Zhang, Qin-Liang Wang, Hao Zhang
To clarify the rapid formation and evolutionary mechanisms of an extremely severe and persistent haze and fog (HF) episode that occurred in central-eastern China from Dec 20 to 25, 2015, a novel campaign was conducted and vertical profiles of wind, temperature, light extinction coefficient (LEC) and PM2.5 concentration were used to analyze the rapid formation and evolutionary mechanisms of this HF episode. The substantial downward transportation of regional pollution from high layers and stagnant weather conditions favorable for the local pollution accumulation were the two main causes of the rapid increase in pollutant concentration...
November 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29111377/mass-spectrometry-analyses-of-normal-and-polyglutamine-expanded-ataxin-3-reveal-novel-interaction-partners-involved-in-mitochondrial-function
#13
Line V Kristensen, Felix S Oppermann, Matthias J Rauen, Karina Fog, Thorsten Schmidt, Jana Schmidt, Tina Harmuth, Rasmus Hartmann-Petersen, Kenneth Thirstrup
Deubiquitinating enzymes (DUBs) play important roles in a variety of cellular processes, including regulation of protein homeostasis. The DUB ataxin-3 is an enzyme implicated in protein quality control mechanisms. In the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3), ataxin-3 contains an expanded polyglutamine (polyQ) stretch that leads to aggregation of the protein and neuronal dysfunction. Increasing the understanding of ataxin-3 protein interaction partners could help to elucidate disease mechanisms...
October 27, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29111022/association-of-freezing-of-gait-with-nigral-iron-accumulation-in-patients-with-parkinson-s-disease
#14
Rajini M Naduthota, Arush Arun Honnedevasthana, Abhishek Lenka, Jitender Saini, Sairam Geethanath, Rose Dawn Bharath, Rita Christopher, Ravi Yadav, Arun Kumar Gupta, Pramod Kumar Pal
BACKGROUND AND PURPOSE: The objective of this work was to investigate whether patients with and without freezing of gait (FOG) in Parkinson's disease (PD) have differences in iron accumulation in substantia nigra using R2* relaxometry. MATERIALS AND METHODS: This study included seventeen PD patients with FOG [FOG (+)], equal number of age and gender matched patients without FOG [FOG (-)] and 34 healthy controls (HC). T2* images were obtained from a 3-Tesla MRI system using multi-echo sequence...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29104219/smart-collaborative-caching-for-information-centric-iot-in-fog-computing
#15
Fei Song, Zheng-Yang Ai, Jun-Jie Li, Giovanni Pau, Mario Collotta, Ilsun You, Hong-Ke Zhang
The significant changes enabled by the fog computing had demonstrated that Internet of Things (IoT) urgently needs more evolutional reforms. Limited by the inflexible design philosophy; the traditional structure of a network is hard to meet the latest demands. However, Information-Centric Networking (ICN) is a promising option to bridge and cover these enormous gaps. In this paper, a Smart Collaborative Caching (SCC) scheme is established by leveraging high-level ICN principles for IoT within fog computing paradigm...
November 1, 2017: Sensors
https://www.readbyqxmd.com/read/29096573/drug-related-problems-and-changes-in-drug-utilization-after-medication-reviews-in-nursing-homes-in-oslo-norway
#16
Amura Francesca Fog, Gunnar Kvalvaag, Knut Engedal, Jørund Straand
OBJECTIVE: We describe the drug-related problems (DRPs) identified during medication reviews (MRs) and the changes in drug utilization after MRs at nursing homes in Oslo, Norway. We explored predictors for the observed changes. DESIGN: Observational before-after study. SETTING: Forty-one nursing homes. INTERVENTION: MRs performed by multidisciplinary teams during November 2011 to February 2014. SUBJECTS: In all, 2465 long-term care patients...
November 2, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29089922/effects-of-subthalamic-and-nigral-stimulation-on-gait-kinematics-in-parkinson-s-disease
#17
Marlieke Scholten, Johannes Klemt, Melanie Heilbronn, Christian Plewnia, Bastiaan R Bloem, Friedemann Bunjes, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss
Conventional subthalamic deep brain stimulation for Parkinson's disease (PD) presumably modulates the spatial component of gait. However, temporal dysregulation of gait is one of the factors that is tightly associated with freezing of gait (FOG). Temporal locomotor integration may be modulated differentially at distinct levels of the basal ganglia. Owing to its specific descending brainstem projections, stimulation of the substantia nigra pars reticulata (SNr) area might modulate spatial and temporal parameters of gait differentially compared to standard subthalamic nucleus (STN) stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29079421/a-prospective-study-of-falls-in-relation-to-freezing-of-gait-and-response-fluctuations-in-parkinson-s-disease
#18
Yasuyuki Okuma, Ana Lígia Silva de Lima, Jiro Fukae, Bastiaan R Bloem, Anke H Snijders
INTRODUCTION: Falls are a disabling feature of Parkinson's disease (PD). In this prospective study we investigated: (1) in which motor state patients with PD fallmost often; and (2) whether freezing of gait (FOG) and dyskinesias contribute to falls. METHODS: Patients with PD who had fallen at least once in the previous year and had wearing-off were recruited. During six months, patients complete a standardized fall report. We analyzed data regarding fall circumstances and motor state at the time of each first 10 falls...
October 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29078616/technical-means-to-improve-image-quality-during-thoracoscopic-procedures
#19
Dominique Gossot, Madalina Grigoroiu, Emmanuel Brian, Agathe Seguin-Givelet
Although high definition imaging systems are now available in the operating room (OR), the displayed image quality during video-assisted procedures is often poor. This is due to several factors such as inappropriate angle of vision, instable endoscope, lens soiling and fogging. The aim of this article is to provide information about some technical and technological means that make it possible to keep a perfect picture all along a thoracoscopic procedure.
2017: J Vis Surg
https://www.readbyqxmd.com/read/29075506/physiological-characterization-of-secondary-metabolite-producing-penicillium-cell-factories
#20
Sietske Grijseels, Jens Christian Nielsen, Jens Nielsen, Thomas Ostenfeld Larsen, Jens Christian Frisvad, Kristian Fog Nielsen, Rasmus John Normand Frandsen, Mhairi Workman
BACKGROUND: Penicillium species are important producers of bioactive secondary metabolites. However, the immense diversity of the fungal kingdom is only scarcely represented in industrial bioprocesses and the upscaling of compound production remains a costly and labor intensive challenge. In order to facilitate the development of novel secondary metabolite producing processes, two routes are typically explored: optimization of the native producer or transferring the enzymatic pathway into a heterologous host...
2017: Fungal Biology and Biotechnology
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