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Fausto Castagnetti, Francesco Di Raimondo, Antonio De Vivo, Antonio Spitaleri, Gabriele Gugliotta, Francesco Fabbiano, Isabella Capodanno, Donato Mannina, Marzia Salvucci, Agostino Antolino, Roberto Marasca, Maurizio Musso, Monica Crugnola, Stefana Impera, Elena Trabacchi, Caterina Musolino, Francesco Cavazzini, Giuseppe Mineo, Patrizia Tosi, Carmela Tomaselli, Michele Rizzo, Sergio Siragusa, Miriam Fogli, Riccardo Ragionieri, Alessandro Zironi, Simona Soverini, Giovanni Martinelli, Michele Cavo, Paolo Vigneri, Fabio Stagno, Gianantonio Rosti, Michele Baccarani
Chronic myeloid leukemia (CML) treatment is based on company-sponsored and academic trials testing different tyrosine kinase inhibitors (TKIs) as first-line therapy. These studies included patients selected according to many inclusion-exclusion criteria, particularly age and comorbidities, with specific treatment obligations. In daily clinical practice (real-life), inclusion-exclusion criteria do not exist and the treatment outcome does not only depend on the choice of first-line TKI, but also on second- and third-line TKIs...
October 22, 2016: American Journal of Hematology
C Schlenstedt, A Shalash, M Muthuraman, D Falk, K Witt, G Deuschl
The aim of this meta-analysis was to summarize the short- and long-term effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on gait and freezing of gait (FOG) in Parkinson's disease and to detect predictors of post-stimulation outcome. A comprehensive review of the literature was conducted up to October 2015 using Medline Ovid databases for studies analyzing the effect of bilateral STN-DBS on FOG and/or gait. Sixteen studies with available data for the gait item (no. 29) of the Unified Parkinson's Disease Rating Scale (UPDRS) and six studies with the FOG item (no...
October 20, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Bonan Li, Lixin Wang, Kudzai F Kaseke, Lin Li, Mary K Seely
Soil moisture is a key variable in dryland ecosystems since it determines the occurrence and duration of vegetation water stress and affects the development of weather patterns including rainfall. However, the lack of ground observations of soil moisture and rainfall dynamics in many drylands has long been a major obstacle in understanding ecohydrological processes in these ecosystems. It is also uncertain to what extent rainfall controls soil moisture dynamics in fog dominated dryland systems. To this end, in this study, twelve to nineteen months' continuous daily records of rainfall and soil moisture (from January 2014 to August 2015) obtained from three sites (one sand dune site and two gravel plain sites) in the Namib Desert are reported...
2016: PloS One
Daniel W Birch, Jerry T Dang, Noah J Switzer, Namdar Manouchehri, Xinzhe Shi, Ghassan Hadi, Shahzeer Karmali
BACKGROUND: Intraoperative hypothermia during both open and laparoscopic abdominal surgery may be associated with adverse events. For laparoscopic abdominal surgery, the use of heated insufflation systems for establishing pneumoperitoneum has been described to prevent hypothermia. Humidification of the insufflated gas is also possible. Past studies on heated insufflation have shown inconclusive results with regards to maintenance of core temperature and reduction of postoperative pain and recovery times...
October 19, 2016: Cochrane Database of Systematic Reviews
Victor Delpizzo Castagno, Manuel Augusto Pereira Vilela, Rodrigo Dalke Meucci, Deiner Paulo Martins Resende, Francis Huszar Schneid, Rafael Getelina, Maurício Rodrigues Nasiloski, Anaclaudia Gastal Fassa
PURPOSE: Hofstetter's equations are based on studies of Amplitude of Accommodation (AA) with methodological limitations, particularly in the case of children younger than 10 years of age. The aim of this study is to evaluate AA by age, gender, economic status, and time of day as well as accommodative insufficiency prevalence. METHODS: A cross-sectional study was conducted with 867 schoolchildren aged 6-16 years attending two public schools in the urban area of the South Brazilian city of Pelotas...
October 18, 2016: Current Eye Research
Kevin Wong, Jessica R Levi
OBJECTIVES/HYPOTHESIS: Evaluate the readability of pediatric otolaryngology-related patient education materials from leading online sources. STUDY DESIGN: Cross-sectional analysis. METHODS: All pediatric otolaryngology-related articles from the online patient health libraries of the top 10 US News & World Report-ranked children's hospitals, top 5 Doximity-ranked pediatric otolaryngology fellowships, and the American Academy of Otolaryngology-Head and Neck Surgery were collected...
October 18, 2016: Laryngoscope
Michael Bobian, Aron Kandinov, Nour El-Kashlan, Peter F Svider, Adam J Folbe, Ross Mayerhoff, Jean Anderson Eloy, S Naweed Raza
OBJECTIVES/HYPOTHESIS: Despite the increasing role of mobile applications (apps) in patient education, there has been little inquiry evaluating the quality of these resources. Because poor health literacy has been associated with inferior health outcomes, evaluating the quality of patient education materials takes on great importance. Our objective was to employ validated readability tools for the evaluation of gastroesophageal reflux (GERD) mobile apps. METHODS: GERD-specific apps found in the Apple App Store (Apple Inc...
October 18, 2016: Laryngoscope
Stephen W Marshall, Kevin M Guskiewicz, Viswanathan Shankar, Michael McCrea, Robert C Cantu
BACKGROUND: The epidemiology of sports-related concussion is not well-described in the literature. This paper presents a descriptive epidemiology of concussion in seven high school and collegiate sports. METHODS: We used the data from Concussion Prevention Initiative (CPI), which enrolled 8905 athletes at 210 high schools and 26 colleges in a prospective cohort study of 7 sports (football, men's and women's soccer, men's and women's lacrosse, and men's and women's ice hockey) between 1999 and 2001...
December 2015: Injury Epidemiology
Sietske Grijseels, Jens Christian Nielsen, Milica Randelovic, Jens Nielsen, Kristian Fog Nielsen, Mhairi Workman, Jens Christian Frisvad
A new soil-borne species belonging to the Penicillium section Canescentia is described, Penicillium arizonense sp. nov. (type strain CBS 141311(T) = IBT 12289(T)). The genome was sequenced and assembled into 33.7 Mb containing 12,502 predicted genes. A phylogenetic assessment based on marker genes confirmed the grouping of P. arizonense within section Canescentia. Compared to related species, P. arizonense proved to encode a high number of proteins involved in carbohydrate metabolism, in particular hemicellulases...
October 14, 2016: Scientific Reports
Younsuk Dong, Steven I Safferman, Jeff Ostahowski, Tom Herold, Ronald Panter
When a fast-food restaurant's wastewater containing fats, oil and grease (FOG) is discharged into a collection system, it builds up over time and clogs pipes. Similarly, when such wastewater flows into a septic soil treatment system, it adheres to the surface of inlet pipes, gravel/distribution media and soil, restricting the flow and eventually clogging the septic soil treatment system. In this study, an enzymatic pretreatment system was tested on wastewater from a fast-food restaurant to determine its effectiveness in preventing septic soil treatment system clogging...
October 11, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Jaiprakash, Amrita Singhai, Gazala Habib, Ramya Sunder Raman, Tarun Gupta
Fine aerosol fraction (particulate matter with aerodynamic diameter <= 1.0 μm (PM)1.0) over the Indian Institute of Technology Delhi campus was monitored day and night (10 h each) at 30 m height from November 2009 to March 2010. The samples were analyzed for 5 ions (NH4(+), NO3(-), SO4(2-), F(-), and Cl(-)) and 12 trace elements (Na, K, Mg, Ca, Pb, Zn, Fe, Mn, Cu, Cd, Cr, and Ni). Importantly, secondary aerosol (sulfate and nitrate) formation was observed during dense foggy events, supporting the fog-smog-fog cycle...
October 10, 2016: Environmental Science and Pollution Research International
Ken Ikeda, Takehisa Hirayama, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
Objective Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic neurons. Rotigotine is a non-ergot dopamine receptor agonist (DA). Its transdermal patch maintains the effective concentrations for 24 hours. Freezing of gait (FOG) is a common and devastating symptom in PD patients. Little is known about therapeutic effects of rotigotine on FOG in PD patients. Herein we compared how three non-ergot DAs of rotigotine, pramipexole LA and ropinirole CR influence FOG, besides classical motor deficits in PD patients...
2016: Internal Medicine
Bharath Kumar, Abhishek Chakraborty, S N Tripathi, Deepika Bhattu
Non-refractory submicron (NR-PM1) aerosols were measured during the late winter period (February-March) via an Aerodyne High Resolution Time of Flight Aerosols Mass Spectrometer (HR-ToF-AMS) along with Black Carbon (BC) and trace gasses in an industrial city, Kanpur, situated in the Gangetic Plain (GP) of India. The composition of NR-PM1 aerosols was dominated by organics (54%), followed by inorganics (36%), and BC (10%). Source apportionment via Positive Matrix Factorization (PMF) of AMS measured organic aerosols (OAs) revealed 6 factors...
October 12, 2016: Environmental Science. Processes & Impacts
Hai Zhu, Fuchao Yang, Jing Li, Zhiguang Guo
A superhydrophilic surface with two superhydrophobic circular patterns was fabricated via a simple and rapid route, showing outstanding fog harvesting properties with a water collection rate (WCR) of 1316.9 mg h(-1) cm(-2). Water collection can be repeated on the sample 10 times without obvious change in the WCR.
October 13, 2016: Chemical Communications: Chem Comm
Min He, Yue Ding, Jing Chen, Yanlin Song
Fast removal of condensates from surfaces is of great significance due to the enhancing thermal transfer coefficient and continuous condensation. But the losing super-hydrophobicity of lotus leaves questions us what kind of surface morphologies meets the self-removal of condensates? The uphill movement of condensates in textured surfaces is vital to avoiding flood and facilitating self-removal. Here, super-hydrophobic micro-tower arrays were designed to explore the spontaneous uphill movement and Wenzel to Cassie transition as well as the self-removal of condensates...
October 5, 2016: ACS Nano
Eric M Wilcox, Rick M Thomas, Puppala S Praveen, Kristina Pistone, Frida A-M Bender, Veerabhadran Ramanathan
The introduction of cloud condensation nuclei and radiative heating by sunlight-absorbing aerosols can modify the thickness and coverage of low clouds, yielding significant radiative forcing of climate. The magnitude and sign of changes in cloud coverage and depth in response to changing aerosols are impacted by turbulent dynamics of the cloudy atmosphere, but integrated measurements of aerosol solar absorption and turbulent fluxes have not been reported thus far. Here we report such integrated measurements made from unmanned aerial vehicles (UAVs) during the CARDEX (Cloud Aerosol Radiative Forcing and Dynamics Experiment) investigation conducted over the northern Indian Ocean...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Dimitris N Papageorgiou, Elena Karkoulia, Alexandra Amaral-Psarris, Pavel Burda, Katarzyna Kolodziej, Jeroen Demmers, Jörg Bungert, Tomas Stopka, John Strouboulis
DNMT1 is the maintenance DNA methyltransferase shown to be essential for embryonic development and cellular growth and differentiation in many somatic tissues in mammals. Increasing evidence has also suggested a role for DNMT1 in repressing gene expression through interactions with specific transcription factors. Previously, we identified DNMT1 as an interacting partner of the TR2/TR4 nuclear receptor heterodimer in erythroid cells, implicated in the developmental silencing of fetal β-type globin genes in the adult stage of human erythropoiesis...
September 28, 2016: Biochimica et Biophysica Acta
Božidar Bratina, Andrej Šorgo, Janez Kramberger, Urban Ajdnik, Lidija Fras Zemljič, Janez Ekart, Riko Šafarič
After a ban on the depositing of untreated sludge in landfills, the sludge from municipal and industrial water-treatment plants can be regarded as a problem. Waste products of the water treatment process can be a problem or an opportunity - a source for obtaining raw materials. In the European Union, raw sludge and fats, oil and grease (FOG) from municipal and industrial wastewater treatment plants (WWTP) cannot be deposited in any natural or controlled environment. For this reason, it must be processed (stabilized, dried) to be used later as a fertilizer, building material, or alternative fuel source suitable for co-incineration in high temperature furnaces (power plants or concrete plants)...
December 1, 2016: Journal of Environmental Management
Ting Xu, Yucai Lin, Miaoxin Zhang, Weiwei Shi, Yongmei Zheng
An artificial periodic roughness-gradient conical copper wire (PCCW) can be fabricated by inspiration from cactus spines and wet spider silks. PCCW can harvest fog on periodic points of the conical surface from air and transports the drops for a long distance without external force, which is attributed to dynamic as-released energy generated from drop deformation in drop coalescence, in addition to both gradients of geometric curve (inducing Laplace pressure) and periodic roughness (inducing surface energy difference)...
October 4, 2016: ACS Nano
Steffi Sunny, George Cheng, Daniel Daniel, Peter Lo, Sebastian Ochoa, Caitlin Howell, Nicolas Vogel, Adnan Majid, Joanna Aizenberg
Camera-guided instruments, such as endoscopes, have become an essential component of contemporary medicine. The 15-20 million endoscopies performed every year in the United States alone demonstrate the tremendous impact of this technology. However, doctors heavily rely on the visual feedback provided by the endoscope camera, which is routinely compromised when body fluids and fogging occlude the lens, requiring lengthy cleaning procedures that include irrigation, tissue rubbing, suction, and even temporary removal of the endoscope for external cleaning...
September 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
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