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https://www.readbyqxmd.com/read/28918954/contemporary-management-of-vesicoureteral-reflux
#1
REVIEW
Perviz Hajiyev, Berk Burgu
CONTEXT: Vesicoureteral reflux (VUR) remains the most interesting topic of pediatric urology due to the dynamic nature of recent controversial publications. Starting from the need for a diagnosis to the necessity and effectiveness of treatment in preventing scars, VUR remains in the mist. Although recent strong evidence helped as fog lights in this blurriness, more data are required for achieving crystal clearance. This article aims to summarize and discuss the current state of the evidence regarding VUR management...
September 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28912451/unveiling-co2-heterogeneous-freezing-plumes-during-champagne-cork-popping
#2
Gérard Liger-Belair, Daniel Cordier, Jacques Honvault, Clara Cilindre
Cork popping from clear transparent bottles of champagne stored at different temperatures (namely, 6, 12, and 20 °C) was filmed through high-speed video imaging in the visible light spectrum. During the cork popping process, a plume mainly composed of gaseous CO2 with traces of water vapour freely expands out of the bottleneck through ambient air. Most interestingly, for the bottles stored at 20 °C, the characteristic grey-white cloud of fog classically observed above the bottlenecks of champagne stored at lower temperatures simply disappeared...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911664/smog-induces-oxidative-stress-and-microbiota-disruption
#3
REVIEW
Tit-Yee Wong
Smog is created through the interactions between pollutants in the air, fog, and sunlight. Air pollutants, such as carbon monoxide, heavy metals, nitrogen oxides, ozone, sulfur dioxide, volatile organic vapors, and particulate matters, can induce oxidative stress in human directly or indirectly through the formation of reactive oxygen species. The outermost boundary of human skin and mucous layers are covered by a complex network of human-associated microbes. The relation between these microbial communities and their human host are mostly mutualistic...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28905177/readability-assessment-of-online-patient-education-materials-provided-by-the-european-association-of-urology
#4
Patrick Betschart, Valentin Zumstein, Maico Bentivoglio, Daniel Engeler, Hans-Peter Schmid, Dominik Abt
PURPOSE: To assess the readability of the web-based patient education material provided by the European Association of Urology. MATERIALS AND METHODS: English patient education materials (PEM) as available in May 2017 were obtained from the EAU website. Each topic was analyzed separately using six well-established readability assessment tools, including Flesch-Kincaid Grade Level (FKGL), SMOG Grade Level (SMOG), Coleman-Liau Index (CLI), Gunning Fog Index (GFI), Flesch Reading Ease Formula (FRE) and Fry Readability Graph (FRG)...
September 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28902804/long-term-patient-reported-outcomes-after-surgery-for-superior-canal-dehiscence-syndrome
#5
Mohammed S Alkhafaji, Sanskriti Varma, Seth E Pross, Jeffrey D Sharon, Jason C Nellis, Charles C Della Santina, Lloyd B Minor, John P Carey
OBJECTIVE: Evaluate the long-term patient-reported outcomes of surgery for superior canal dehiscence syndrome (SCDS). STUDY DESIGN: Cross-sectional survey. SETTING: Tertiary referral center. PATIENTS: Adults who have undergone surgery for SCDS with at least 1 year since surgery. MAIN OUTCOME MEASURE(S): Primary outcome: change in symptoms that led to surgery. SECONDARY OUTCOMES: change in 11 SCDS-associated symptoms, change in psychosocial metrics, and willingness to recommend surgery to friends with SCDS...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28901751/sulfate-aerosols-promote-lung-cancer-metastasis-by-epigenetically-regulating-the-epithelial-to-mesenchymal-transition-emt
#6
Yang Yun, Rui Gao, Huifeng Yue, Lin Guo, Guangke Li, Nan Sang
Secondary inorganic aerosols (SIA), particularly sulfate aerosols, are central particulate matter (PM) constituents of severe haze formation in China and exert profound impacts on human health; however, our understanding of the mechanisms by which sulfate aerosols cause malignancy in lung carcinogenesis remains incomplete. Here, we show that exposure to secondary inorganic aerosols induced the invasion and migration of lung epithelial cells, and that (NH4)2SO4 exerted the most serious effects in vitro and promoted lung tumor metastasis in vivo...
September 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28895946/dna-sip-based-genome-centric-metagenomics-identifies-key-long-chain-fatty-acid-degrading-populations-in-anaerobic-digesters-with-different-feeding-frequencies
#7
Ryan M Ziels, Diana Z Sousa, H David Stensel, David A C Beck
Fats, oils and greases (FOG) are energy-dense wastes that can be added to anaerobic digesters to substantially increase biomethane recovery via their conversion through long-chain fatty acids (LCFAs). However, a better understanding of the ecophysiology of syntrophic LCFA-degrading microbial communities in anaerobic digesters is needed to develop operating strategies that mitigate inhibitory LCFA accumulation from FOG. In this research, DNA stable isotope probing (SIP) was coupled with metagenomic sequencing for a genome-centric comparison of oleate (C18:1)-degrading populations in two anaerobic codigesters operated with either a pulse feeding or continuous-feeding strategy...
September 12, 2017: ISME Journal
https://www.readbyqxmd.com/read/28890341/cueing-for-people-with-parkinson-s-disease-with-freezing-of-gait-a-narrative-review-of-the-state-of-the-art-and-novel-perspectives
#8
REVIEW
Ginis Pieter, Nackaerts Evelien, Nieuwboer Alice, Heremans Elke
Freezing, which manifests during gait and other movements, is an incapacitating motor symptom experienced by many patients with Parkinson's disease (PD). In rehabilitation, auditory and visual cueing methods are commonly applied to evoke a more goal-directed type of motor control and, as such, reduce freezing severity in patients with PD. In this narrative review, we summarize the current evidence regarding the effects of external cueing in patients with PD with freezing of gait (FOG) and provide suggestions on how to further improve cueing effectiveness with emerging technological developments...
September 7, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28890315/subthalamic-neural-entropy-is-a-feature-of-freezing-of-gait-in-freely-moving-people-with-parkinson-s-disease
#9
Judy Syrkin-Nikolau, Mandy Miller Koop, Thomas Prieto, Chioma Anidi, Muhammad Furqan Afzal, Anca Velisar, Zack Blumenfeld, Talora Martin, Megan Trager, Helen Bronte-Stewart
The goal of this study was to investigate subthalamic (STN) neural features of Freezers and Non-Freezers with Parkinson's disease (PD), while freely walking without freezing of gait (FOG) and during periods of FOG, which were better elicited during a novel turning and barrier gait task than during forward walking. METHODS: Synchronous STN local field potentials (LFPs), shank angular velocities, and ground reaction forces were measured in fourteen PD subjects (eight Freezers) off medication, OFF deep brain stimulation (DBS), using an investigative, implanted, sensing neurostimulator (Activa® PC+S, Medtronic, Inc...
September 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28888377/rapid-deployment-valves-finally-the-fog-is-lifting-benefits-beyond-crossclamp-and-bypass-times
#10
EDITORIAL
Günther Laufer, Dominik Wiedemann, Walter Randolph Chitwood
No abstract text is available yet for this article.
August 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28888239/urban-climate-in-the-tokyo-metropolitan-area-in-japan
#11
REVIEW
Jun Matsumoto, Fumiaki Fujibe, Hideo Takahashi
Long-term climate changes related with urbanization in Tokyo, Japan, and recent temperature and heavy rainfall distribution in the Tokyo metropolitan area are reviewed. A relatively high temperature increase in annual mean temperature at the rate of 3.0°C/century was detected in Tokyo for the period 1901-2015. Some observational evidence showed the existence of both thermal and mechanical effects of urbanization on recent heavy rainfall occurrences, and modeling studies also support precipitation enhancement...
September 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28886015/freezing-during-tapping-tasks-in-patients-with-advanced-parkinson-s-disease-and-freezing-of-gait
#12
Arnaud Delval, Luc Defebvre, Céline Tard
INTRODUCTION: Parkinson's disease patients with freezing of gait also experience sudden motor blocks (freezing) during other repetitive motor tasks. We assessed the proportion of patients with advanced PD and freezing of gait who also displayed segmental "freezing" in tapping tasks. METHODS: Fifteen Parkinson's disease patients with freezing of gait were assessed. Freezing of gait was evaluated using a standardized gait trajectory with the usual triggers. Patients performed repetitive tapping movements (as described in the MDS-UPDRS task) with the hands or the feet in the presence or absence of a metronome set to 4 Hz...
2017: PloS One
https://www.readbyqxmd.com/read/28885483/assessing-readability-and-reliability-of-online-patient-information-regarding-vestibular-schwannoma
#13
Harry Spiers, Nikul Amin, Raj Lakhani, Andrew J Martin, Parag M Patel
HYPOTHESIS: The aim of this study is to objectively assess the quality and readability of websites related to vestibular schwannomas. BACKGROUND: Patients are increasingly seeking information on confirmed or suspected diagnoses through the Internet. Clinicians are often concerned regarding the accuracy, quality, and readability of web-based sites. METHODS: Online information relating to vestibular schwannoma was searched using the three most popular search engines...
September 6, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28885028/numerical-calculation-method-of-apparent-contact-angles-on-heterogeneous-double-roughness-surfaces
#14
Jian Dong, Yanli Jin, He Dong, Li Sun
Double-roughness surfaces can be used to mimic lotus surfaces. The apparent contact angles (ACAs) of droplets on these surfaces were first calculated by Herminghaus. Then Patankar utilized the pillar model to improve the Herminghaus approach and put forward the formulas for ACAs calculation of the homogeneous double-roughness surfaces where the dual-scale structures and the bases were the same wettable materials. In this paper, we propose a numerical calculation method of ACAs on the heterogeneous double-roughness surfaces where the dual-scale structures and the bases are made of different wettable materials...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28860483/selective-lrrk2-kinase-inhibition-reduces-phosphorylation-of-endogenous-rab10-and-rab12-in-human-peripheral-mononuclear-blood-cells
#15
Kenneth Thirstrup, Justus C Dächsel, Felix S Oppermann, Douglas S Williamson, Garrick P Smith, Karina Fog, Kenneth V Christensen
Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of familial and sporadic Parkinson's disease (PD). To support clinical development of LRRK2 inhibitors as disease-modifying treatment in PD biomarkers for kinase activity, target engagement and kinase inhibition are prerequisite tools. In a combined proteomics and phosphoproteomics study on human peripheral mononuclear blood cells (PBMCs) treated with the LRRK2 inhibitor Lu AF58786 a number of putative biomarkers were identified...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858210/hplc-hrms-quantification-of-the-ichthyotoxin-karmitoxin-from-karlodinium-armiger
#16
Aaron John Christian Andersen, Lívia Soman de Medeiros, Sofie Bjørnholt Binzer, Silas Anselm Rasmussen, Per Juel Hansen, Kristian Fog Nielsen, Kevin Jørgensen, Thomas Ostenfeld Larsen
Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quantified in laboratory-grown cultures using high-performance liquid chromatography (HPLC) coupled to electrospray ionisation high-resolution time-of-flight mass spectrometry (HRMS). Prior to the quantification of karmitoxin, a standard of karmitoxin was purified from K...
August 31, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28855889/l-dopa-and-freezing-of-gait-in-parkinson-s-disease-objective-assessment-through-a-wearable-wireless-system
#17
Antonio Suppa, Ardian Kita, Giorgio Leodori, Alessandro Zampogna, Ettore Nicolini, Paolo Lorenzi, Rosario Rao, Fernanda Irrera
Freezing of gait (FOG) is a leading cause of falls and fractures in Parkinson's disease (PD). The episodic and rather unpredictable occurrence of FOG, coupled with the variable response to l-DOPA of this gait disorder, makes the objective evaluation of FOG severity a major clinical challenge in the therapeutic management of patients with PD. The aim of this study was to examine and compare gait, clinically and objectively, in patients with PD, with and without FOG, by means of a new wearable system. We also assessed the effect of l-DOPA on FOG severity and specific spatiotemporal gait parameters in patients with and without FOG...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28855887/identification-of-characteristic-motor-patterns-preceding-freezing-of-gait-in-parkinson-s-disease-using-wearable-sensors
#18
Luca Palmerini, Laura Rocchi, Sinziana Mazilu, Eran Gazit, Jeffrey M Hausdorff, Lorenzo Chiari
Freezing of gait (FOG) is a disabling symptom that is common among patients with advanced Parkinson's disease (PD). External cues such as rhythmic auditory stimulation can help PD patients experiencing freezing to resume walking. Wearable systems for automatic freezing detection have been recently developed. However, these systems detect a FOG episode after it has happened. Instead, in this study, a new approach for the prediction of FOG (before it actually happens) is presented. Prediction of FOG might enable preventive cueing, reducing the likelihood that FOG will occur...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28852102/conditions-for-barrel-and-clam-shell-liquid-drops-to-move-on-bio-inspired-conical-wires
#19
Cheng Luo, Xiang Wang
It has been reported that, in a foggy environment, water drops with either barrel or clam-shell shapes are capable of self-running on conical wire-like structures, such as cactus spines, spider silk, and water striders' legs. On the other hand, the corresponding moving mechanisms are still not quite understood. For instance, it is unclear under what conditions clam-shell drops would move from the tip towards the root on a conical wire. In this work, based on the balance of forces, we derive conditions for a drop to self-transport towards or away from the root...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843342/readability-of-online-materials-for-dupuytren-s-contracture
#20
Pauline Joy F Santos, David A Daar, Austin Badeau, Amber Leis
STUDY DESIGN: Descriptive. BACKGROUND: Dupuytren's contracture is a common disorder involving fibrosis of the palmar fascia. As patients are increasingly using online materials to gather health care information, it is imperative to assess the readability and appropriateness of this content. The recommended grade level for patient educational materials is seventh to eighth grade according to the National Institutes of Health. This study aims to assess the readability and content of online patient resources for Dupuytren's contracture...
August 23, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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