Read by QxMD icon Read


Trine Maxel, Pernille Fog Svendsen, Kamille Smidt, Jesper Krogh Lauridsen, Birgitte Brock, Steen Bønlykke Pedersen, Jørgen Rungby, Agnete Larsen
Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels, and insulin resistance. In adipose tissue, zinc facilitates insulin signaling. Circulating zinc levels are altered in obesity, diabetes, and PCOS; and zinc supplementation can ameliorate metabolic disturbances in PCOS. In adipose tissue, expression of zinc influx transporter ZIP14 varies with body mass index (BMI), clinical markers of metabolic syndrome, and peroxisome proliferator-activated receptor gamma (PPARG). In this study, we investigated expression levels of ZIP14 and PPARG in subcutaneous adipose tissue of 36 PCOS women (17 lean and 19 obese women) compared with 23 healthy controls (7 lean and 16 obese women)...
2017: Frontiers in Endocrinology
Luis Santos, Javier Fernandez-Rio, Kristian Winge, Beatriz Barragán-Pérez, Lucía González-Gómez, Vicente Rodríguez-Pérez, Vicente González-Díez, Alejandro Lucía, Eliseo Iglesias-Soler, Xurxo Dopico-Calvo, Miguel Fernández-Del-Olmo, Miguel Del-Valle, Miguel Blanco-Traba, Oscar E Suman, Javier Rodríguez-Gómez
BACKGROUND: Progressive resistance exercise (PRE) can have a positive effect in individuals with Parkinson's disease (PD). However, the effect of PRE may vary with the clinical subtype of PD. To date, no study has assessed the effects of PRE in the different subtypes of PD. AIM: The aim of the present study was to assess the effects of PRE in PD patients with akinesia and rigidity (AR-subtype). DESIGN: A randomized controlled trial was conducted...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
Olaf Deppe, Georg Dorner, Stefan König, Tim Martin, Sven Voigt, Steffen Zimmermann
In the following paper, we present an industry perspective of inertial sensors for navigation purposes driven by applications and customer needs. Microelectromechanical system (MEMS) inertial sensors have revolutionized consumer, automotive, and industrial applications and they have started to fulfill the high end tactical grade performance requirements of hybrid navigation systems on a series production scale. The Fiber Optic Gyroscope (FOG) technology, on the other hand, is further pushed into the near navigation grade performance region and beyond...
March 11, 2017: Sensors
B Meenakshi-Sundaram, J R Furr, E Malm-Buatsi, B Boklage, E Nguyen, D Frimberger, B W Palmer
INTRODUCTION: The adoption of robot-assisted laparoscopic (RAL) procedures in the field of urology has occurred rapidly, but is, to date, without pediatric-specific instrumentation. Surgical fog is a significant barrier to safe and efficient laparoscopy. This appears to be a significant challenge when adapting three-dimensional 8.5-mm scopes to use in pediatric RAL surgery. The objective of the present study was to compare matched controls from a prospectively collected database to procedures that were performed utilizing special equipment and a protocol to minimize surgical fog in pediatric RAL procedures...
February 24, 2017: Journal of Pediatric Urology
Jia-Wei Wang, Yu-Qing Zhang, Xiao-Hua Zhang, Yun-Peng Wang, Ji-Ping Li, Yong-Jie Li
BACKGROUND: Postural instability and gait disorder(PIGD) in Parkinson's disease (PD) have been a great challenge in the clinical practice since PIGD is closely linked to major morbidity and mortality in PD. Pedunculopontine nucleus (PPN) has been considered as a potential promising target for deep brain stimulation (DBS) in the treatment of PIGD. Thus, this meta-analysis of individual patient data (IPD) was performed to assess the effects of PPN DBS on PIGD in PD patients and explore the factors predicting good outcome...
March 6, 2017: World Neurosurgery
Laia Masvidal, Laura Hulea, Luc Furic, Ivan Topisirovic, Ola Larsson
Translation is fundamental for many biologic processes as it enables cells to rapidly respond to stimuli without requiring de novo mRNA synthesis. The mammalian/mechanistic target of rapamycin (mTOR) is a key regulator of translation. Although mTOR affects global protein synthesis, translation of a subset of mRNAs appears to be exceptionally sensitive to changes in mTOR activity. Recent efforts to catalog these mTOR-sensitive mRNAs resulted in conflicting results. Whereas ribosome-profiling almost exclusively identified 5'-terminal oligopyrimidine (TOP) mRNAs as mTOR-sensitive, polysome-profiling suggested that mTOR also regulates translation of non-TOP mRNAs...
February 10, 2017: RNA Biology
Ken R Catchpole, Elyse Hallett, Sam Curtis, Tannaz Mirchi, Colby P Souders, Jennifer T Anger
Recent studies exploring the effects of surgical robots on teamwork are revealing challenges not reflected in clinical studies. This study is a sub analysis of observational data collected from 89 procedures utilising the da Vinci systems. Previous analyses had demonstrated interactions between flow disruptions and contextual factors. This study sought a more granular analysis to provide better insight for improvement. Raters sub-classified disruptions, based upon the original notes, grouped according to four operative phases (pre-robot; docking; surgeon on console; undocking; and finish)...
March 8, 2017: Ergonomics
Malcolm A MacIver, Lars Schmitz, Ugurcan Mugan, Todd D Murphey, Curtis D Mobley
The evolution of terrestrial vertebrates, starting around 385 million years ago, is an iconic moment in evolution that brings to mind images of fish transforming into four-legged animals. Here, we show that this radical change in body shape was preceded by an equally dramatic change in sensory abilities akin to transitioning from seeing over short distances in a dense fog to seeing over long distances on a clear day. Measurements of eye sockets and simulations of their evolution show that eyes nearly tripled in size just before vertebrates began living on land...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Our research team has previously used four Electroencephalography (EEG) leads to successfully detect and predict Freezing of Gait (FOG) in Parkinson's disease (PD). However, it remained to be determined whether these four sensor locations that were arbitrarily chosen based on their role in motor control are indeed the most optimal for FOG detection. The aim of this study was therefore to determine the most optimal location and combination of sensors to detect FOG amongst a 32-channel EEG montage using our EEG classification system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Kimia Nazarzadeh, Sridhar P Arjunan, Dinesh K Kumar, Debi Prasad Das
In this study, we have analyzed the accelerometer data recorded during gait analysis of Parkinson disease patients for detecting freezing of gait (FOG) episodes. The proposed method filters the recordings for noise reduction of the leg movement changes and computes the wavelet coefficients to detect FOG events. Publicly available FOG database was used and the technique was evaluated using receiver operating characteristic (ROC) analysis. Results show a higher performance of the wavelet feature in discrimination of the FOG events from the background activity when compared with the existing technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Kevin Golovin, Mathew Boban, Joseph M Mabry, Anish Tuteja
The past decade saw a drastic increase in the understanding and applications of superhydrophobic surfaces (SHSs). Water beads up and effortlessly rolls off a SHS due to its combination of low surface energy and texture. Whether being used for drag reduction, stain repellency, self-cleaning, fog harvesting, or heat transfer applications (to name a few), the durability of a SHS is critically important. Although a handful of purportedly durable SHSs have been reported, there are still no criteria available for systematically designing a durable SHS...
March 20, 2017: ACS Applied Materials & Interfaces
Dalong Zhang, Qingjie Du, Zhi Zhang, Xiaocong Jiao, Xiaoming Song, Jianming Li
Although atmospheric vapour pressure deficit (VPD) has been widely recognized as the evaporative driving force for water transport, the potential to reduce plant water consumption and improve water productivity by regulating VPD is highly uncertain. To bridge this gap, water transport in combination with plant productivity was examined in tomato (Solanum lycopersicum L.) plants grown under contrasting VPD gradients. The driving force for water transport was substantially reduced in low-VPD treatment, which consequently decreased water loss rate and moderated plant water stress: leaf desiccation, hydraulic limitation and excessive negative water potential were prevented by maintaining water balance...
March 7, 2017: Scientific Reports
Aimi L Forsyth, Serene S Paul, Natalie E Allen, Catherine Sherrington, Victor S C Fung, Colleen G Canning
BACKGROUND AND PURPOSE: Flexed truncal posture is common in people with Parkinson disease (PD); however, little is known about the mechanisms responsible or its effect on physical performance. This cross-sectional study aimed to establish the reliability of a truncal posture measurement and explore relationships between PD impairments and truncal posture, as well as truncal posture and balance and mobility. METHODS: A total of 82 people with PD participated. Truncal posture was measured in standing as the distance between vertebra C7 and a wall...
April 2017: Journal of Neurologic Physical Therapy: JNPT
Joke Spildooren, Sarah Vercruysse, Elke Heremans, Brook Galna, Geert Verheyden, Griet Vervoort, Alice Nieuwboer
BACKGROUND AND PURPOSE: Individuals with Parkinson disease exhibit decreased axial head-pelvis rotation. Consequently, they turn more en bloc than healthy controls, which may contribute to freezing during turning. We wanted to understand the influence of auditory cueing and an attentional strategy on turning and how this related to freezing of gait (FOG). METHODS: Fifteen participants with Parkinson disease and FOG were asked to turn 180° during baseline condition, unilateral cueing, and an attentional strategy prompting to start the turn with head rotation first...
April 2017: Journal of Neurologic Physical Therapy: JNPT
Md Abul Kalam Azad, Tobias Krause, Leon Danter, Albert Baars, Kerstin Koch, Wilhelm Barthlott
Fog collecting meshes show a great potential to ensure the availability of a supply of sustainable fresh water in certain arid regions. In most cases, the meshes are made of hydrophilic smooth fibers. Based on the study of plant surfaces, we analyzed the fog-collection of different polyethylene terephthalate (PET) fibers with different cross-sections and different surface structures with the aim of developing optimized biomimetic fog collectors. Water droplet movement and the onset of dripping from fiber samples were compared...
March 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Chang-Liang Yao, Wen-Zhi Yang, Wei Si, Yao Shen, Nai-Xia Zhang, Hua-Li Chen, Hui-Qin Pan, Min Yang, Wan-Ying Wu, De-An Guo
Targeted identification of potentially bioactive molecules from herbal medicines is often stymied by the insufficient chromatographic separation, ubiquitous matrix interference, and pervasive isomerism. An enhanced targeted identification strategy is presented and validated by the selective identification of flavonoid O-glycosides (FOGs) from Carthamus tinctorius. It consists of four steps: (i) enhanced separation and detection by offline two-dimensional liquid chromatography/LTQ-Orbitrap MS (offline 2D-LC/LTQ-Orbitrap MS) using collision-induced dissociation (CID) and high-energy C-trap dissociation (HCD); (ii) improved identification of the major aglycones by acid hydrolysis and LC-SPE-NMR; (iii) simplified spectral elucidation by high-resolution diagnostic product ions/neutral loss filtering; and (iv) more convincing structural identification by matching an in-house library...
March 31, 2017: Journal of Chromatography. A
Matthias P Fabritius, Philipp M Kazmierczak, Kolja M Thierfelder, Wolfgang G Kunz
No abstract text is available yet for this article.
March 2, 2017: Clinical Neuroradiology
Jiaping Zheng, Hong Yu
BACKGROUND: Electronic health records (EHRs) are a rich resource for developing applications to engage patients and foster patient activation, thus holding a strong potential to enhance patient-centered care. Studies have shown that providing patients with access to their own EHR notes may improve the understanding of their own clinical conditions and treatments, leading to improved health care outcomes. However, the highly technical language in EHR notes impedes patients' comprehension...
March 2, 2017: Journal of Medical Internet Research
Ruwei Ou, Bei Cao, Qianqian Wei, Yanbing Hou, Yaqian Xu, Wei Song, Bi Zhao, Huifang Shang
Uric acid (UA) is a natural antioxidant and iron scavenger in the human body, which has been hypothesized to exert an anti-oxidative effect in Parkinson's disease (PD). This study aimed to investigate the relationship between serum UA levels and freezing of gait (FOG) in PD. A total of 321 Chinese PD patients with fasting serum UA evaluated were included in the cross-sectional study. Demographics, clinical features, and therapeutic regimen were collected. The Unified PD Rating Scale (UPDRS) III and Hoehn and Yahr (H and Y) stage were used to evaluate the severity of disease, and the Frontal Assessment Battery (FAB) and Montreal Cognitive Assessment (MoCA) scales were used to assess the cognitive function...
March 1, 2017: Neurological Sciences
Ana Lígia Silva de Lima, Luc J W Evers, Tim Hahn, Lauren Bataille, Jamie L Hamilton, Max A Little, Yasuyuki Okuma, Bastiaan R Bloem, Marjan J Faber
Despite the large number of studies that have investigated the use of wearable sensors to detect gait disturbances such as Freezing of gait (FOG) and falls, there is little consensus regarding appropriate methodologies for how to optimally apply such devices. Here, an overview of the use of wearable systems to assess FOG and falls in Parkinson's disease (PD) and validation performance is presented. A systematic search in the PubMed and Web of Science databases was performed using a group of concept key words...
March 1, 2017: Journal of Neurology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"