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https://www.readbyqxmd.com/read/27325294/temporal-frequency-of-knockdown-resistance-mutations-f1534c-and-v1016g-in-aedes-aegypti-in-chiang-mai-city-thailand-and-the-impact-of-the-mutations-on-the-efficiency-of-thermal-fogging-spray-with-pyrethroids
#1
Suriya Plernsub, Jassada Saingamsook, Jintana Yanola, Nongkran Lumjuan, Pongsri Tippawangkosol, Catherine Walton, Pradya Somboon
In Thailand, control of dengue outbreaks is currently attained by the use of space sprays, particularly thermal fogging using pyrethroids, with the aim of killing infected Aedes mosquito vectors in epidemic areas. However, the principal dengue vector, Aedes aegypti, is resistant to pyrethroids conferred mainly by mutations in the voltage-gated sodium channel gene, F1534C and V1016G, termed knockdown resistance (kdr). The objectives of this study were to determine the temporal frequencies of F1534C and V1016G in Ae...
October 2016: Acta Tropica
https://www.readbyqxmd.com/read/23418585/the-h-current-in-periglomerular-dopaminergic-neurons-of-the-mouse-olfactory-bulb
#2
Angela Pignatelli, Mirta Borin, Alex Fogli Iseppe, Cristina Gambardella, Ottorino Belluzzi
The properties of the hyperpolarization-activated cation current (I(h)) were investigated in rat periglomerular dopaminergic neurons using patch-clamp recordings in thin slices. A reliable identification of single dopaminergic neurons was made possible by use of a transgenic line of mice expressing eGFP under the tyrosine hydroxylase promoter. At 37 °C and minimizing the disturbance of the intracellular milieu with perforated patches, this current shows a midpoint of activation around -82.7 mV, with a significant level of opening already at rest, thereby giving a substantial contribution to the resting potential, and ultimately playing a relevant function in the control of the cell excitability...
2013: PloS One
https://www.readbyqxmd.com/read/20738018/effects-of-5-fu
#3
Peter M Wigmore, Sarah Mustafa, Maha El-Beltagy, Laura Lyons, Jariya Umka, Geoff Bennett
5-fluorouracil (5-FU) is a chemotherapeutical agent used to treat cancers including breast and colorectal. Working as an antimetabolite to prevent cell proliferation, it primarily inhibits the enzyme thymidylate synthase blocking the thymidine formation required for DNA synthesis. Although having a relatively short half-life (< 30 mins) it readily enters the brain by passive diffusion. Clinically, it is used both as a single agent or in combination with other chemotherapies and has been associated with the long-term side effects of cognitive impairment, known as "chemo brain" or "chemo fog" These accounts have come primarily from patients undergoing treatment for breast cancer who report symptoms including confusion and memory impairment, which can last for months to years...
2010: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/14613857/gata-and-fog2-transcription-factors-differentially-regulate-the-promoter-for-kv4-2-k-channel-gene-in-cardiac-myocytes-and-pc12-cells
#4
Ying Jia, Koichi Takimoto
OBJECTIVE: Kv4.2 subunits are major components of transient outward K(+) channels in cardiac myocytes and somatodendritic A-type channels in neurons. To identify molecular mechanisms underlying transcriptional regulation of Kv4.2 gene, we have isolated and characterized the promoter for the rat Kv4.2 gene. METHODS: PCR-based amplification of cDNA end (5'RACE) and RNase protection assays were used to determine transcription start sites. Transient transfection of Kv4...
November 1, 2003: Cardiovascular Research
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