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JOURNAL ARTICLE
Jingjing Liu, Wentao Tang, Lechi Ye, Gengyun Miao, Mengsu Zeng, Liheng Liu
RATIONALE AND OBJECTIVES: The conversion success rate (CSR) has crucial implication for clinical outcomes of initially unresectable colorectal liver metastases (CRLM) following conversion therapy. This study aimed to develop a simple predictive scoring model for identifying CSR according to baseline magnetic resonance imaging (MRI) features, and confirm its performance and prognostic significance in a validation cohort. METHODS: A total of 155 consecutive patients with initially unresectable CRLM were retrospectively reviewed in the study...
May 10, 2024: Academic Radiology
#2
JOURNAL ARTICLE
Thomas J Vogl, Jason Freichel, Tatjana Gruber-Rouh, Nour-Eldin Abdelrehim Nour-Eldin, Wolf-Otto Bechstein, Stefan Zeuzem, Nagy N N Naguib, Ulrich Stefenelli, Hamzah Adwan
The aim of this study was to analyze the long-term results of different locoregional treatments for colorectal cancer liver metastases (CRLM), including transarterial chemoembolization (TACE), laser-induced thermotherapy (LITT) and microwave ablation (MWA). A total of 2140 patients with CRLM treated at our department between 1993 and 2020 were included in this retrospective study. The patients were divided into the following groups: LITT (573 patients; median age: 62 years), TACE + LITT (346 patients; median age: 62 years), MWA (67 patients; median age: 59 years), TACE + MWA (152 patients; median age: 65 years), and TACE (1002 patients; median age: 62 years)...
April 30, 2024: Cancers
#3
JOURNAL ARTICLE
Jennifer A Kalil, Lucyna Krzywon, Oran Zlotnik, Hugo Perrier, Stephanie K Petrillo, Prosanto Chaudhury, Erik Schadde, Peter Metrakos
(1) Background: Despite advances in surgical technique and systemic chemotherapy, some patients with multifocal, bilobar colorectal liver metastases (CRLM) remain unresectable. These patients may benefit from surgical debulking of liver tumors in combination with chemotherapy compared to chemotherapy alone. (2) Methods: A retrospective study including patients evaluated for curative intent resection of CRLM was performed. Patients were divided into three groups: those who underwent liver resection with recurrence within 6 months (subtotal debulked, SD), those who had the first stage only of a two-stage hepatectomy (partially debulked, PD), and those never debulked (ND)...
April 29, 2024: Cancers
#4
JOURNAL ARTICLE
Mario Serradilla-Martín, Celia Villodre, Laia Falgueras-Verdaguer, Natalia Zambudio-Carroll, José T Castell-Gómez, Juan L Blas-Laina, Vicente Borrego-Estella, Carlos Domingo-Del-Pozo, Gabriel García-Plaza, Francisco J González-Rodríguez, Eva M Montalvá-Orón, Ángel Moya-Herraiz, Sandra Paterna-López, Miguel A Suárez-Muñoz, Maialen Alkorta-Zuloaga, Gerardo Blanco-Fernández, Enrique Dabán-Collado, Miguel A Gómez-Bravo, José I Miota-de-Llamas, Fernando Rotellar, Belinda Sánchez-Pérez, Santiago Sánchez-Cabús, David Pacheco-Sánchez, Juan C Rodríguez-Sanjuan, María A Varona-Bosque, Lucía Carrión-Álvarez, Sofía de la Serna-Esteban, Cristina Dopazo, Elena Martín-Pérez, David Martínez-Cecilia, María J Castro-Santiago, Dimitri Dorcaratto, Marta L Gutiérrez-Díaz, José M Asencio-Pascual, Fernando Burdío-Pinilla, Roberto Carracedo-Iglesias, Alfredo Escartín-Arias, Benedetto Ielpo, Gonzalo Rodríguez-Laiz, Andrés Valdivieso-López, Emilio De-Vicente-López, Vicente Alonso-Orduña, José M Ramia
(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11...
April 26, 2024: Cancers
#5
REVIEW
Stamatios Kokkinakis, Ioannis A Ziogas, Jose D Llaque Salazar, Dimitrios P Moris, Georgios Tsoulfas
Colorectal liver metastasis (CRLM) is a disease entity that warrants special attention due to its high frequency and potential curability. Identification of "high-risk" patients is increasingly popular for risk stratification and personalization of the management pathway. Traditional regression-based methods have been used to derive prediction models for these patients, and lately, focus has shifted to artificial intelligence-based models, with employment of variable supervised and unsupervised techniques. Multiple endpoints, like overall survival (OS), disease-free survival (DFS) and development or recurrence of postoperative complications have all been used as outcomes in these studies...
April 25, 2024: Cancers
#6
JOURNAL ARTICLE
Gaetano Piccolo, Matteo Barabino, Giorgio Ghilardi, Riccardo Masserano, Francesca Lecchi, Guglielmo Niccolò Piozzi, Paolo Pietro Bianchi
BACKGROUND: The European Association of Endoscopic Surgery (EAES) recommends, with strong evidence, the use of indocyanine green (ICG) fluorescence imaging combined with intraoperative ultrasound (IOUS) to improve identification of superficial liver tumors. This study reports the use of ICG for the detection of colorectal liver metastases (CRLMs) during minimally invasive liver resection. METHODS: A single-center consecutive series of minimally invasive (laparoscopic and robotic) hepatic resections for CRLMs was prospectively evaluated (April 2019 and October 2023)...
April 24, 2024: Cancers
#7
JOURNAL ARTICLE
Osman Melih Topcuoglu, Tolga Orhan, Ayşegul Gormez, Nalan Alan
OBJECTIVES: To compare the survival and objective response rate (ORR) of the patients receiving estimated tumor absorbed dose (ETAD) <140 Gy versus ETAD ≥140 Gy in patients with advanced chemorefractory colorectal carcinoma liver metastases (CRCLM) treated with yttrium-90 transarterial radioembolization (90Y TARE). MATERIALS AND METHODS: Between August 2016 and August 2023 adult patients with unresectable, chemorefractory CRCLM treated with 90Y TARE using glass particles, were retrospectively enrolled...
May 10, 2024: British Journal of Radiology
#8
JOURNAL ARTICLE
Enoch Chang, Franklin C L Wong, Beth A Chasen, William D Erwin, Prajnan Das, Emma B Holliday, Albert C Koong, Ethan B Ludmir, Bruce D Minsky, Sonal S Noticewala, Grace L Smith, Cullen M Taniguchi, Maria J Rodriguez, Sam Beddar, Rachael M Martin-Paulpeter, Joshua S Niedzielski, Gabriel O Sawakuchi, Emil Schueler, Luis A Perles, Lianchun Xiao, Janio Szklaruk, Peter C Park, Arvind N Dasari, Ahmed O Kaseb, Bryan K Kee, Sunyoung S Lee, Michael J Overman, Jason A Willis, Robert A Wolff, Ching-Wei D Tzeng, Jean-Nicolas Vauthey, Eugene J Koay
BACKGROUND: Traditional constraints specify that 700 cc of liver should be spared a hepatotoxic dose when delivering liver-directed radiotherapy to reduce the risk of inducing liver failure. We investigated the role of single photon emission computed tomography (SPECT) to identify and preferentially avoid functional liver during liver-directed radiation treatment planning in patients with preserved liver function but limited functional liver volume after receiving prior hepatotoxic chemotherapy or surgical resection...
May 10, 2024: JNCI Cancer Spectrum
#9
JOURNAL ARTICLE
Makoto Ando, Nobuyuki Takemura, Ryo Oikawa, Yuhi Yoshizaki, Fuyuki Inagaki, Fuminori Mihara, Tomomichi Kiyomatsu, Kazuhiko Yamada, Norihiro Kokudo
BACKGROUND: Colorectal cancer can invade adjacent organs, but rarely metastasizes to the regional lymph nodes (LNs) of the invaded organ. Herein, we report a case of rectal cancer invading the ileum and metastasized to the regional ileal LNs. CASE PRESENTATION: A 77-year-old male presented abdominal pain and anorexia, diagnosed with rectal cancer invading the small intestine and concurrently metastasized to the regional LN of the intestine and liver. High anterior resection and partial resection of the small intestine was performed, then, the patient was referred to our hospital for chemotherapy...
May 11, 2024: Surgical Case Reports
#10
RANDOMIZED CONTROLLED TRIAL
De-Shen Wang, Chao Ren, Shan-Shan Li, William Pat Fong, Xiao-Jun Wu, Jian Xiao, Bin-Kui Li, Yun Zheng, Pei-Rong Ding, Gong Chen, Miao-Zhen Qiu, Zhi-Qiang Wang, Feng-Hua Wang, Hui-Yan Luo, Feng Wang, Xiao-Zhong Wang, Ling-Yun Wang, De-Jin Xie, Tao Chen, Li-Ren Li, Zhen-Hai Lu, Xiao-Hui Zhai, Tian-Shu Liu, Ying Yuan, Jia-Qi Chen, Qiong Tan, Zhi-Zhong Pan, De-Sen Wan, Rong Zhang, Yun-Fei Yuan, Rui-Hua Xu, Yu-Hong Li
BACKGROUND: It remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes in a cohort of RAS/BRAF wild-type colorectal cancer (CRC) patients with initially unresectable colorectal liver metastases (CRLM). To that end, we sought to comparatively evaluate the efficacy and safety of cetuximab plus FOLFOXIRI (triplet arm) versus cetuximab plus FOLFOX (doublet arm) as a conversion regimen (i.e., unresectable to resectable) in CRC patients with unresectable CRLM...
May 2024: PLoS Medicine
#11
JOURNAL ARTICLE
Yangkun Li, Qilin Li, Lei Mu, Yibing Hu, Chang Yan, Hui Zhao, Yulong Mi, Xiaolan Li, Deding Tao, Jichao Qin
Abnormal nuclear enlargement is a diagnostic and physical hallmark of malignant tumors. Large nuclei are positively associated with an increased risk of developing metastasis; however, a large nucleus is inevitably more resistant to cell migration due to its size. The present study demonstrated that the nuclear size of primary colorectal cancer (CRC) cells at an advanced stage was larger than cells at an early stage. In addition, the nuclei of CRC liver metastases were larger than those of the corresponding primary CRC tissues...
2024: International Journal of Biological Sciences
#12
JOURNAL ARTICLE
Yue Yang, Yunsong Chen, Zhaogang Liu, Zhibin Chang, Zhicheng Sun, Lei Zhao
BACKGROUND AND AIMS: Both Non-alcoholic fatty liver disease (NAFLD) and colorectal cancer (CRC) are prevalent worldwide. The effect of concomitant NAFLD on the risk of colorectal liver metastasis (CRLM) and its mechanisms have not been definitively elucidated. METHODS: We observed the effect of concomitant NAFLD on CRLM in the mouse model, and explored the underlying mechanisms of specific myeloid-derived suppressor cells (MDSCs) recruitment, then tested the therapeutic application based on the mechanisms; finally we validated our findings in the clinical samples...
May 7, 2024: Cellular and Molecular Gastroenterology and Hepatology
#13
JOURNAL ARTICLE
Michał Skroński, Natalia Olszewska, Paweł Nyckowski, Anna Ukleja, Joanna Lisowska, Maciej Słodkowski, Bruno Szczygieł
<b><br>Introduction:</b> Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. Distant metastases are usually located in the liver and are present in 50% of patients.</br> <b><br>Aim:</b> The aim of this study is to evaluate changes in body composition and phase angle before and after surgical treatment of CRC liver metastases, as well as survival time and treatment costs.</br> <b><br>Material and methods:</b> The study included 134 patients who received 174 surgeries for CRC liver metastases...
March 5, 2024: Polski Przeglad Chirurgiczny
#14
JOURNAL ARTICLE
Taichi Kondo, Yuuki Hirai, Takayuki Abe, Kouan Orii
Prosthetic valve endocarditis (PVE) is rare but devastating. A 69-year old man admitted for active endocarditis caused by Streptococcus pasteurianus. Antibiotic therapy was started, but the patient developed bowel obstruction owing to cancer with multiple liver metastases, and underwent transverse colectomy. Following colectomy, antibiotic agent was given continued for 4 weeks after and mitral valve replacement( MVR) using a bioprosthesis was performed. Oral antibiotic therapy was continued for six months after MVR to avoid infection recurrence...
May 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
#15
JOURNAL ARTICLE
Suzan Elmaagacli, Christoph Thiele, Franziska Meister, Philipp Menne, Daniel Truhn, Steven W M Olde Damink, Johannes Bickenbach, Ulf Neumann, Sven Arke Lang, Florian Vondran, Iakovos Amygdalos
Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer and liver resection with complete tumor removal is the best treatment option for these patients. This study examines the predictive ability of three-dimensional lung volumetry (3DLV) based on preoperative computerized tomography (CT), to predict postoperative pulmonary complications in patients undergoing major liver resection for CRLM. Patients undergoing major curative liver resection for CRLM between 2010 and 2021 with a preoperative CT scan of the thorax within 6 weeks of surgery, were included...
May 8, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Emil Östrand, Jenny Rystedt, Jennie Engstrand, Petter Frühling, Oskar Hemmingsson, Per Sandström, Malin Sternby Eilard, Bobby Tingstedt, Pamela Buchwald
BACKGROUND: Resection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and ≥1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery. METHODS: Using data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included...
May 8, 2024: BJS Open
#17
JOURNAL ARTICLE
Damiano Patrono, Nicola De Stefano, Renato Romagnoli
PURPOSE OF REVIEW: Tumor entities represent an increasing indication for liver transplantation (LT). This review addresses the most contentious indications of LT in transplant oncology. RECENT FINDINGS: Patient selection based on tumor biology in LT for colorectal cancer liver metastases (CRLM) demonstrated promising long-term outcomes and preserved quality of life despite high recurrence rates. In selected cases, LT for intrahepatic cholangiocarcinoma (iCCA) is feasible, with acceptable survival even in high-burden cases responsive to chemotherapy...
May 9, 2024: Current Opinion in Organ Transplantation
#18
JOURNAL ARTICLE
Masatoshi Nomura, Mitsuyoshi Tei, Takayoshi Goto, Masataka Hirano, Kentaro Nishida, Soichiro Mori, Yukihiro Yoshikawa, Koki Tamai, Takuya Hamakawa, Daisuke Takiuchi, Masanori Tsujie, Yusuke Akamaru
BACKGROUND: Colorectal cancer (CRC) often metastasizes to the liver, lungs, lymph nodes, and peritoneum but rarely to the bladder, small intestine, and skin. We here report the rare metastasis of anal cancer in the left bladder wall, followed by metastases to the small intestine and skin, after abdominoperineal resection and left lateral lymph node dissection with chemotherapy in a patient with clinician Stage IVa disease. CASE PRESENTATION: A 66-year-old man presented with 1-month history of bloody stool and anal pain and diagnosed with clinical Stage IVa anal cancer with lymph node and liver metastases (cT3, N3 [#263L], M1a [H1])...
May 8, 2024: Surgical Case Reports
#19
JOURNAL ARTICLE
Joshua M K Davis, Muhammad Khalid Khan Niazi, Ansley B Ricker, Thomas E Tavolara, Jordan N Robinson, Bayram Annanurov, Kaylee Smith, Rohit Mantha, Jimmy Hwang, Ruchi Shrestha, David A Iannitti, John B Martinie, Erin H Baker, Metin N Gurcan, Dionisios Vrochides
BACKGROUND AND OBJECTIVES: Deep learning models (DLMs) are applied across domains of health sciences to generate meaningful predictions. DLMs make use of neural networks to generate predictions from discrete data inputs. This study employs DLM on prechemotherapy cross-sectional imaging to predict patients' response to neoadjuvant chemotherapy. METHODS: Adult patients with colorectal liver metastasis who underwent surgery after neoadjuvant chemotherapy were included...
May 7, 2024: Journal of Surgical Oncology
#20
Yingying Huang, Shuai Zhang, Xueqing Hu, Xiangyang Wang, Yunbo Zhao, Zhongkang Li
BACKGROUND: Colorectal cancer (CRC) with the Raf murine sarcoma viral oncogene homolog B ( BRAF ) V600E had a relatively poor prognosis. Anaplastic lymphoma kinase ( ALK ) fusion and the mesenchymal-to-epithelial transition factor ( MET ) amplification have been recognized as potentially important therapeutic targets in non-small cell lung cancer (NSCLC). However, both of them are of extremely lower frequencies (<2%) in metastatic CRC, and few studies have mentioned the real application of their inhibitors in CRC treatment...
2024: AME Case Reports
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