keyword
MENU ▼
Read by QxMD icon Read
search

Systems pharmacology

keyword
https://www.readbyqxmd.com/read/27933606/relaxin-like-peptides-in-male-reproduction-a-human-perspective
#1
REVIEW
Richard Ivell, Alexander I Agoulnik, Ravinder Anand-Ivell
The relaxin family of peptide hormones and their cognate G-protein coupled receptors are becoming physiologically well characterized in the cardiovascular system and particularly in female reproductive processes. Much less is known about the physiology and pharmacology of these peptides in male reproduction, particularly as regards the human. H2-relaxin is involved in prostate function and growth, while INSL3 is a major product of the testicular Leydig cells and in the adult appears to modulate steroidogenesis and germ cell survival...
December 9, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27933293/differences-in-the-mechanical-properties-of-the-developing-cerebral-cortical-proliferative-zone-between-mice-and-ferrets-at-both-the-tissue-and-single-cell-levels
#2
Arata Nagasaka, Tomoyasu Shinoda, Takumi Kawaue, Makoto Suzuki, Kazuaki Nagayama, Takeo Matsumoto, Naoto Ueno, Ayano Kawaguchi, Takaki Miyata
Cell-producing events in developing tissues are mechanically dynamic throughout the cell cycle. In many epithelial systems, cells are apicobasally tall, with nuclei and somata that adopt different apicobasal positions because nuclei and somata move in a cell cycle-dependent manner. This movement is apical during G2 phase and basal during G1 phase, whereas mitosis occurs at the apical surface. These movements are collectively referred to as interkinetic nuclear migration, and such epithelia are called "pseudostratified...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27933142/salidroside-reduces-tau-hyperphosphorylation-via-up-regulating-gsk-3%C3%AE-phosphorylation-in-a-tau-transgenic-drosophila-model-of-alzheimer-s-disease
#3
Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun, Shengdi Chen
BACKGROUND: Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment against AD. Salidroside (Sal) is the main effective component of Rhodiola rosea L., which has several pharmacological activities. The objective of this study was to investigate the efficacy of Sal in the treatment of AD transgenic Drosophila and the associated mechanisms...
2016: Translational Neurodegeneration
https://www.readbyqxmd.com/read/27932946/increased-brain-neurotensin-and-ntsr2-lead-to-weak-nociception-in-ntsr3-sortilin-knockout-mice
#4
Christelle Devader, Sébastien Moreno, Morgane Roulot, Emmanuel Deval, Thomas Dix, Carlos R Morales, Jean Mazella
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2, and NTSR3 also called sortilin). Pharmacological approaches and generation of NTSR1 and NTSR2-deficient mice allowed to determine the NT-induced antipsychotic like behavior, the inhibitory of weak fear memory and the nociceptive signaling in a rat formalin tonic pain model to NTSR1. Conversely, the effects of NT on thermal and tonic nociceptions were mediated by NTSR2. However, the role of NTSR3/sortilin on the neurotensinergic system was not investigated...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27932550/spermaurin-an-la1-like-peptide-from-the-venom-of-the-scorpion-scorpio-maurus-palmatus-improves-sperm-motility-and-fertilization-in-different-mammalian-species
#5
Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M Abd El Aziz, Jessica Escoffier, Julien Bessonnat, Claire-Maëlle Fovet, Michel De Waard, Sylviane Hennebicq, Vincent Aucagne, Pierre F Ray, Eric Schmitt, Philippe Bulet, Christophe Arnoult
STUDY QUESTION: Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER: We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in different mammalian species, including human, and improved fertilization outcome in mouse IVF experiments. WHAT IS KNOWN ALREADY: Any disturbance of sperm motility has a strong impact on fertilization and can lead to subfertility or infertility...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932549/proteolytic-degradation-of-heat-shock-protein-a2-occurs-in-response-to-oxidative-stress-in-male-germ-cells-of-the-mouse
#6
Elizabeth G Bromfield, R John Aitken, Eileen A McLaughlin, Brett Nixon
STUDY QUESTION: Does oxidative stress compromise the protein expression of heat shock protein A2 (HSPA2) in the developing germ cells of the mouse testis? SUMMARY ANSWER: Oxidative stress leads to the modification of HSPA2 by the lipid aldehyde 4-hydroxynonenal (4HNE) and initiates its degradation via the ubiquitin-proteasome system. WHAT IS KNOWN ALREADY: Previous work has revealed a deficiency in HSPA2 protein expression within the spermatozoa of infertile men that have failed fertilization in a clinical setting...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932349/nadph-oxidase-2-and-atherothrombosis-insight-from-chronic-granulomatous-disease
#7
REVIEW
Francesco Violi, Roberto Carnevale, Lorenzo Loffredo, Pasquale Pignatelli, John I Gallin
The phagocytic cell enzyme NADPH oxidase-2 (Nox2) is critical for killing micro-organisms via production of reactive oxygen species and thus is a key element of the innate immune system. Nox2 is also detectable in endothelial cells and platelets where it has vasoconstrictive and aggregating properties, respectively. Patients with X-linked chronic granulomatous disease with hereditary Nox2 deficiency not only have impaired bacterial killing but, in association with loss of Nox2 function, also have enhanced carotid artery dilation, impaired platelet-related thrombosis, and reduced carotid atherosclerotic burden...
December 8, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27932214/a-regional-assessment-of-chemicals-of-concern-in-surface-waters-of-four-midwestern-united-states-national-parks
#8
Sarah M Elliott, David D VanderMeulen
Anthropogenic chemicals and their potential for adverse biological effects raise concern for aquatic ecosystem health in protected areas. During 2013-15, surface waters of four Midwestern United States national parks were sampled and analyzed for wastewater indicators, pharmaceuticals, personal care products, and pesticides. More chemicals and higher concentrations were detected at the two parks with greater urban influences (Mississippi National River and Recreation Area and Indiana Dunes National Lakeshore) than at the two more remote parks (Apostle Islands National Lakeshore and Isle Royale National Park)...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27931153/the-mutagenic-antimutagenic-and-antioxidant-properties-of-hypericum-lydium
#9
Rukiye Boran, Aysel Ugur
CONTEXT: There is a growing market demand for Hypericum sp., a pharmacologically active plant that has been traditionally used to treat various ailments. However, there have been limited studies on the extract or essential oil of Hypericum lydium Boiss (Hypericaceae). OBJECTIVE: This study investigates for the first time the antioxidant, mutagenic and antimutagenic activity of an ethanol extract of H. lydium. MATERIAL AND METHODS: Ethanol extract from aerial parts of H...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27931151/regulation-of-mitochondrial-function-and-glutamatergic-system-are-the-target-of-guanosine-effect-in-traumatic-brain-injury
#10
Fernando Dobrachinski, Rogério da Rosa Gerbatin, Glaubia Sartori, Naiane Ferreira Marques, Ana Paula Pegoraro Zemolin, Luiz Fernando Almeida Silva, Jeferson Luis Franco, Luiz Fernando Freire Royes, Michele Rechia Fighera, Félix Alexandre Antunes Soares
Traumatic brain injury (TBI) is a highly complex multi-factorial disorder. Experimental trauma involves primary and secondary injury cascades that underlie delayed neuronal dysfunction and death. Mitochondrial dysfunction and glutamatergic excitotoxicity are the most important mechanisms of damage. In order to be successful, pharmacologic intervention requires a multifaceted approach. Guanosine (GUO) is known for its neuromodulator effects in different models of brain pathology, which regulates the glutamatergic system...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27929455/neuropharmacological-manipulation-of-restrained-and-free-flying-honey-bees-apis-mellifera
#11
Eirik Søvik, Jenny A Plath, Jean-Marc Devaud, Andrew B Barron
Honey bees demonstrate astonishing learning abilities and advanced social behavior and communication. In addition, their brain is small, easy to visualize and to study. Therefore, bees have long been a favored model amongst neurobiologists and neuroethologists for studying the neural basis of social and natural behavior. It is important, however, that the experimental techniques used to study bees do not interfere with the behaviors being studied. Because of this, it has been necessary to develop a range of techniques for pharmacological manipulation of honey bees...
November 26, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929128/extraordinary-behavioral-entrainment-following-circadian-rhythm-bifurcation-in-mice
#12
Elizabeth M Harrison, Thijs J Walbeek, Jonathan Sun, Jeremy Johnson, Qays Poonawala, Michael R Gorman
The mammalian circadian timing system uses light to synchronize endogenously generated rhythms with the environmental day. Entrainment to schedules that deviate significantly from 24 h (T24) has been viewed as unlikely because the circadian pacemaker appears capable only of small, incremental responses to brief light exposures. Challenging this view, we demonstrate that simple manipulations of light alone induce extreme plasticity in the circadian system of mice. Firstly, exposure to dim nocturnal illumination (<0...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928644/cardioprotection-by-remote-ischemic-conditioning-and-its-signal-transduction
#13
REVIEW
Petra Kleinbongard, Andreas Skyschally, Gerd Heusch
Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the heart (remote conditioning), activate molecular self-defense mechanisms at the target organ heart as well as in other parenchymal organs. Remote conditioning of the heart has been established in many experimental studies and successfully translated to patients. Remote ischemic conditioning by short repetitive cycles of ischemia/reperfusion on an extremity reduces infarct size and improves the prognosis of patients with reperfused myocardial infarction...
December 7, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27927784/adenosine-dependent-phrenic-motor-facilitation-is-inflammation-resistant
#14
Ibis M Agosto-Marlin, Nicole L Nichols, Gordon S Mitchell
Phrenic motor facilitation (pMF) can be elicited by acute intermittent hypoxia (ie. phrenic long-term facilitation, or pLTF), or direct application of pharmacological agonists to the cervical spinal cord. Moderate acute intermittent hypoxia (mAIH, 3X5 min episodes of 35-50 mmHg arterial PO2, 5 min normoxic intervals) induces pLTF by a serotonin-dependent mechanism; mAIH-induced pLTF is abolished by even low levels of systemic inflammation induced by lipopolysaccharide (LPS, 100ug/kg i.p.). In contrast, severe AIH (sAIH, 3X5 min episodes of 25-30mmHg arterial PO2, 5 min intervals) elicits pLTF by a distinct, adenosine-dependent mechanism...
December 7, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27927774/autophagy-inhibition-enhances-sunitinib-efficacy-in-clear-cell-ovarian-carcinoma
#15
Lindsay DeVorkin, Matthew Hattersley, Paul Kim, Jenna Ries, Jaeline Spowart, Michael S Anglesio, Samuel M Levi, David G Huntsman, Ravi K Amaravadi, Jeffrey D Winkler, Anna V Tinker, Julian J Lum
: Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that exhibits low response rates to systemic therapy and poor patient outcomes. Multiple studies in CCOC have revealed expression profiles consistent with increased hypoxia, and our previous data suggests that hypoxia is correlated with increased autophagy in CCOC. Hypoxia-induced autophagy is a key factor promoting tumor cell survival and resistance to therapy. Recent clinical trials with the molecular-targeted receptor tyrosine kinase (RTK) inhibitor sunitinib have demonstrated limited activity...
December 7, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27927703/pharmacokinetics-and-pharmacodynamics-of-oral-mecamylamine-development-of-a-nicotinic-acetylcholine-receptor-antagonist-cognitive-challenge-test-using-modelling-and-simulation
#16
Ricardo Alvarez-Jimenez, Anne Catrien Baakman, Jasper Stevens, Sebastiaan C Goulooze, Ellen P Hart, Robert Rissmann, Joop Ma van Gerven, Geert Jan Groeneveld
A pharmacologic challenge model with a nicotinic antagonist could be an important tool not only to understand the complex role of the nicotinic cholinergic system in cognition, but also to develop novel compounds acting on the nicotinic acetylcholine receptor. The objective was to develop a pharmacokinetic-pharmacodynamic (PKPD) model using nonlinear mixed effects (NLME) methods to quantitate the pharmacokinetics of three oral mecamylamine doses (10, 20 and 30 mg) and correlate the plasma concentrations to the pharmacodynamic effects on a cognitive and neurophysiologic battery of tests in healthy subjects...
December 7, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27927042/pharmacological-treatments-for-methamphetamine-addiction-current-status-and-future-directions
#17
Javier Ballester, Gerald Valentine, Mehmet Sofuoglu
Methamphetamine (MA) abuse remains a global health challenge despite intense research interest in the development of pharmacological treatments. This review provides a summary of clinical trials and human studies on the pharmacotherapy of methamphetamine use disorder (MUD). Areas Covered: We summarize published clinical trials that tested candidate medications for MUD and also conducted PubMed and Google Scholar searches to identify recently completed clinical trials using the keywords "methamphetamine" "addiction" "pharmacotherapy" and "clinical trial...
December 7, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27927032/emerging-drugs-for-the-treatment-of-obesity
#18
Christoffer Martinussen, Kirstine Nyvold Bojsen-Moller, Maria Saur Svane, Thomas Fremming Dejgaard, Sten Madsbad
The increasing prevalence of obesity represents a huge threat to public health and the current pharmacological treatment options are limited. Bariatric surgery is by far the most effective treatment for severe obesity, highlighting the urgent need for new and improved drug therapies. Areas covered: Based on the physiological regulation of energy homeostasis, pharmacological strategies to treat obesity are evaluated with focus on drugs in phase 2 and 3 clinical development. The potential impact of these drugs on current treatment standards and the barriers for development are discussed and set in a historical perspective of previous anti-obesity medications...
December 7, 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27926574/neural-activity-memory-and-dementias-serotonergic-markers
#19
Alfredo Meneses
Dysfunctional memory seems to be a key component of diverse dementias and other neuropsychiatric disorders; unfortunately, no effective treatment exists for this, probably because of the absence of neural biomarkers accompanying it. Diverse neurotransmission systems have been implicated in memory, including serotonin or 5-hydroxytryptamine (5-HT). There are multiple serotonergic pharmacological tools, well-characterized downstream signaling in mammals' species and neural markers providing new insights into memory functions and dysfunctions...
December 6, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27926437/involvement-of-opioid-signaling-in-food-preference-and-motivation-studies-in-laboratory-animals
#20
I Morales, L Font, P J Currie, R Pastor
Motivation is a complex neurobiological process that initiates, directs, and maintains goal-oriented behavior. Although distinct components of motivated behavior are difficult to investigate, appetitive and consummatory phases of motivation are experimentally separable. Different neurotransmitter systems, particularly the mesolimbic dopaminergic system, have been associated with food motivation. Over the last two decades, however, research focusing on the role of opioid signaling has been particularly growing in this area...
2016: Progress in Brain Research
keyword
keyword
48136
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"