Chunyan Liu, Wenjuan Mei, Juan Tang, Qiongjing Yuan, Ling Huang, Miaomiao Lu, Lin Wu, Zhangzhe Peng, Jie Meng, Huixiang Yang, Hong Shen, Ben Lv, Gaoyun Hu, Lijian Tao
BACKGROUND: Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new compound which could effectively inhibit the proliferation of renal fibroblasts in vitro. However, the overall effect of Mefunidone in renal fibrosis remains unknown. METHODS: Sprague-Dawley rats were randomly divided intro 6 groups: sham operation, unilateral ureteral obstruction (UUO), UUO/Mefunidone (25, 50, 100mg/kg/day) and UUO/PFD (500mg/kg/day)...
2015: PloS One