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thymic neoplasm

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https://www.readbyqxmd.com/read/28718205/bcl-2-maturation-pattern-in-t-cells-distinguishes-thymic-neoplasm-hyperplasia-t-lymphoblastic-lymphoma-and-reactive-lymph-nodes
#1
Nicholas Ward, Junaid Baqai, Alexandra Zehnpfennig, Nancy Fine, James Huang, Marc D Smith
Anterior mediastinal biopsies consisting predominantly of small lymphocytes can be a diagnostic challenge, especially in small core biopsies. In these cases, immunophenotyping is often employed using flow cytometry, and/or immunohistochemistry. However, due the overlap in T-cell phenotype between thymic neoplasm/hyperplasia (THY), T lymphoblastic lymphoma (T-LBL) and reactive lymph nodes (RLN), biopsies consisting predominantly of T-cells may still be difficult to differentiate. Previous studies have shown a specific CD3/bcl-2 staining pattern in thymic T cells of humans and mice using flow cytometry...
July 17, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28654574/capecitabine-and-celecoxib-as-a-promising-therapy-for-thymic-neoplasms
#2
Kevin Wood, Elizabeth Byron, Linda Janisch, Ravi Salgia, Manish R Sharma
OBJECTIVES: For patients with unresectable or metastatic thymic epithelial neoplasms, few therapy options are available and outcomes are poor. This case series demonstrates that the combination of capecitabine and celecoxib may be a promising therapeutic option for these patients. MATERIALS AND METHODS: The current report describes the outcomes of 5 patients with thymic neoplasms treated on a drug-drug interaction study of capecitabine and celecoxib in patients with advanced solid malignancies (NCT01705106) conducted at the University of Chicago, plus a sixth patient treated with the same regimen outside of the protocol...
June 26, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28555346/endobronchial-metastasis-from-extrapulmonary-neoplasms-analysis-of-clinicopathologic-features-and-cytological-evaluation-by-bronchial-brushing
#3
Kenji Ikemura, Diana Murro Lin, Colin P Martyn, Ji-Weon Park, Christopher W Seder, Paolo Gattuso
PURPOSE: Bronchial brushings (BB) commonly aid in the diagnosis of primary lung cancer. However, the utility of this method in diagnosing endobronchial metastases (EBM) from extrapulmonic malignancies has not been thoroughly evaluated. The purpose of this study is to evaluate the sensitivity of BB in diagnosing EBM. METHODS: An institutional database was queried for all patients with cytologically or histologically confirmed extrapulmonary EBM identified by endobronchial biopsy between 1978 and 2013...
May 29, 2017: Lung
https://www.readbyqxmd.com/read/28538410/extrapleural-solitary-fibrous-tumor-in-thymic-area-a-case-report
#4
Eun Kyung Jung, Young Yoon Kim, Dong Hoon Lee, Kyung Hwa Lee, Joon Kyoo Lee
RATIONALE: Solitary fibrous tumor (SFT) is a rare benign soft tissue mesenchymal neoplasm. There have been a few reports of extrapleural SFTs although it can occur anywhere in the body. PATIENT CONCERNS: A 30-year-old male presented with an anterior neck mass since one month. DIAGNOSES: Based on physical and radiologic examination, preliminary differential diagnosis was thymic neoplasm or intrathoracic goiter. INTERVENTIONS: We performed surgical excision of the neck mass...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28493800/iaslc-itmig-staging-system-and-lymph-node-map-for-thymic-epithelial-neoplasms
#5
Brett W Carter, Marcelo F Benveniste, Rachna Madan, Myrna C Godoy, Patricia M de Groot, Mylene T Truong, Melissa L Rosado-de-Christenson, Edith M Marom
Thymic epithelial neoplasms are rare malignancies that arise from the thymus and include thymoma, thymic carcinoma, and thymic neuroendocrine tumors. At least 15 different stage classifications have been proposed for thymic epithelial neoplasms and used to varying degrees in clinical practice, many of which have been constructed from small groups of patients. Traditionally, the Masaoka and Masaoka-Koga staging systems have been the schemes most commonly employed, and the latter has been recommended for use by the International Thymic Malignancy Interest Group (ITMIG)...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28486946/thymic-epithelial-tumors-phenotype-relies-on-mir-145-5p-epigenetic-regulation
#6
Teresa Bellissimo, Federica Ganci, Enzo Gallo, Andrea Sacconi, Claudia Tito, Luciana De Angelis, Claudio Pulito, Silvia Masciarelli, Daniele Diso, Marco Anile, Vincenzo Petrozza, Felice Giangaspero, Edoardo Pescarmona, Francesco Facciolo, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi
BACKGROUND: Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We previously identified a set of microRNA (miRNAs) differentially expressed in TETs and normal thymic tissues and among the most significantly deregulated we described the down-regulation of miR-145-5p in TET. Here we describe the mRNAs diversely regulated in TETs and analyze the correlation between these and the miRNAs previously identified, focusing in particular on miR-145-5p...
May 10, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28474330/mucinous-adenocarcinoma-of-the-thymus-report-of-a-case
#7
Fumihiko Kinoshita, Fumihiro Shoji, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Tokujiro Yano, Yoshinao Oda, Yoshihiko Maehara
Thymic mucinous adenocarcinoma is a very rare neoplasm. This tumor has a poor prognosis and its treatment is not established. In addition, the existence of KRAS mutations of thymic mucinous adenocarcinoma is still unknown, despite these mutations are common in lung mucinous adenocarcinoma. We present the case of a 79-year-old woman with primary thymic mucinous adenocarcinoma. Therefore, we reviewed clinico-pathological features of thymic mucinous adenocarcinoma in details and analyzed KRAS gene mutations of the present case...
May 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28431716/invasive-medullary-type-a-thymoma-with-recurrent-distant-metastases
#8
Maria Cecilia Mengoli, Lucia Longo, Susanna Varini, Giulio Rossi, Filippo Lococo
Thymomas are rare epithelial mediastinal tumors showing a certain propensity for local and intrathoracic recurrences. Otherwise, extrathoracic metastases are very rarely reported and are usually associated with type B thymomas or thymic carcinomas. We present a challenging patient with an invasive (Masaoka-Koga stage IIb) medullary type A thymoma with recurrent extrathoracic metastases (pulmonary and vertebral localizations occurring 2 and 7 years after the initial radical thymectomy, respectively). Despite type A thymoma being considered a low-grade malignancy with a scarce propensity to recurrence, the present case should alert clinicians to the possibility of bone metastasis...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28420891/diagnostic-value-of-dual-time-point-f-18-fdg-pet-ct-and-chest-ct-for-the-prediction-of-thymic-epithelial-neoplasms
#9
Takayoshi Shinya, Takashi Tanaka, Junichi Soh, Toshi Matsushita, Shuhei Sato, Shinichi Toyooka, Tadashi Yoshino, Shinichiro Miyoshi, Susumu Kanazawa
We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28419205/comparison-of-clinical-features-and-survival-between-thymic-carcinoma-and-thymic-carcinoid-patients
#10
Yang Zhao, Haiyong Gu, Limin Fan, Ke Han, Jun Yang, Heng Zhao
OBJECTIVES: Thymic carcinoma (TC) and thymic carcinoid (TCD) are aggressive thymic epithelial neoplasms with a poor prognosis. Due to rarity, little is known about their comparative clinical characteristics, treatment outcomes and patterns of relapse. METHODS: A retrospective cohort study was performed on 287 patients with TC and 56 patients with TCD who were treated at the Shanghai Chest Hospital between February 2003 and April 2014. Patient demographics, tumour stage, treatment, pathologic findings and postoperative outcomes were compared between the two tumour types using both multivariable Cox regression analysis and propensity-matched analysis...
April 17, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28355610/thymic-neuroendocrine-neoplasms-biological-behaviour-and-therapy
#11
Jia Ru, Petra Sulentic, Jian-Ming Xu, Ashley B Grossman
No abstract text is available yet for this article.
March 30, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28281549/expression-of-pd-1-and-pd-l1-in-thymic-epithelial-neoplasms
#12
Annikka Weissferdt, Junya Fujimoto, Neda Kalhor, Jaime Rodriguez, Roland Bassett, Ignacio I Wistuba, Cesar A Moran
Thymic epithelial neoplasms are rare tumors that are difficult to diagnose and treat. Programmed death 1 (PD-1) receptor and its ligand (PD-L1) are expressed by various malignancies and are considered a prognostic factor and immunotherapeutic target. We examined the expression of both antibodies in 100 thymic epithelial neoplasms to assess their use as a biomarker and to correlate their expression with clinicopathological parameters. Whole-tissue sections of 74 thymomas and 26 thymic carcinomas were examined...
June 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28219559/neovascularization-of-thymoma-from-left-internal-mammary-artery-bypass-graft
#13
Jordan Y Dubique, Harma Turbendian, Danny Chu
We present the case of a type AB thymoma in a 69-year-old man with previous coronary artery bypass grafting (CABG) in whom angiography revealed a left internal mammary artery graft supplying blood flow to a thymic neoplasm, which simultaneously occluded the graft. This required a redo sternotomy, lysis of pericardial adhesions, complete thymectomy, and redo one vessel off-pump CABG. This case seeks to sensitize physicians to the possibility of coronary adverse events in patients with a previous CABG in the setting of management of mediastinal neoplasms, and it presents the novel findings on cardiac imaging associated with this case...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28212996/analysis-of-a-panel-of-druggable-gene-mutations-and-of-alk-and-pd-l1-expression-in-a-series-of-thymic-epithelial-tumors-tets
#14
Marcello Tiseo, Angela Damato, Lucia Longo, Fausto Barbieri, Federica Bertolini, Alessandro Stefani, Mario Migaldi, Letizia Gnetti, Roberta Camisa, Paola Bordi, Sebastiano Buti, Giulio Rossi
INTRODUCTION: Thymic epithelial tumors (TETs) are rare neoplasms with different prognosis lacking consistent molecular alterations possibly leading to targeted therapy. We collected a consecutive series of TETs aimed at investigating the mutational status of druggable genes (EGFR, c-KIT, KRAS, BRAF, PDGFR-alpha and -beta, HER2 and c-MET) and the expression of ALK and PD-L1. PATIENTS AND METHODS: One hundred twelve consecutive cases of TETs and relative clinico-pathologic features were collected...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28147469/thymoma-and-synchronous-primary-mediastinal-seminomas-with-florid-follicular-lymphoid-hyperplasia-in-the-anterior-mediastinum-a-case-report-and-review-of-the-literature
#15
Hyang-Im Lee, In-Seok Jang, Kyung Nyeo Jeon, Gyung Hyuck Ko, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jeong-Hee Lee
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously...
March 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28116199/a-rare-tumor-with-a-very-rare-initial-presentation-thymic-carcinoma-as-bone-marrow-metastasis
#16
Sonam Sharma, Leelavathi Dawson
Tumors of thymus gland are rare and account for 0.2% to 1.5% of all the neoplasms. They constitute a heterogeneous group that has an unknown etiology and a complex as well as varied biology. This has led to difficulty in their histological classification and in predicting their prognostic and survival markers. Among them, thymic carcinoma is the most aggressive thymic epithelial tumor exhibiting cytological malignant features and a diversity of clinicopathological characteristics that can cause diagnostic dilemmas, misdiagnosis, and therapeutic challenge...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28095872/an-unusual-combined-thymic-carcinoma-composed-of-squamous-cell-carcinoma-and-type-ab-thymoma-a-rare-case-report
#17
Yufeng Jiang, Yang Liu, Xiuying Shi, Xiaoyun Mao, Yang Zhao, Chuifeng Fan
BACKGROUND: Combined thymic carcinoma is a malignant neoplasm of the thymus recently added to the 4th edition of the World Health Organization (WHO) classification of tumors of the lung, pleura, thymus and heart. It involves at least one type of thymic carcinoma and another thymic epithelial tumor. The previously used term "combined thymic epithelial tumor" has been abandoned. CASE PRESENTATION: Here, we present an unusual case of combined thymic carcinoma of the thymus in a 44-year-old male who had suffered from fever, chest pain, chest tightness and shortness of breath...
January 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/27999265/gene-specific-methylation-analysis-in-thymomas-of-patients-with-myasthenia-gravis
#18
Angela Lopomo, Roberta Ricciardi, Michelangelo Maestri, Anna De Rosa, Franca Melfi, Marco Lucchi, Alfredo Mussi, Fabio Coppedè, Lucia Migliore
Thymomas are uncommon neoplasms that arise from epithelial cells of the thymus and are often associated with myasthenia gravis (MG), an autoimmune disease characterized by autoantibodies directed to different targets at the neuromuscular junction. Little is known, however, concerning epigenetic changes occurring in thymomas from MG individuals. To further address this issue, we analyzed DNA methylation levels of genes involved in one-carbon metabolism (MTHFR) and DNA methylation (DNMT1, DNMT3A, and DNMT3B) in blood, tumor tissue, and healthy thymic epithelial cells from MG patients that underwent a surgical resection of a thymic neoplasm...
December 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#19
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27789964/rare-frequency-of-gene-variation-and-survival-analysis-in-thymic-epithelial-tumors
#20
Zhengbo Song, Xinmin Yu, Yiping Zhang
OBJECTIVE: Thymic epithelial tumor (TET) is a rare mediastinal neoplasm and little is known about its genetic variability and prognostic factors. This study investigated the genetic variability and prognostic factors of TET. PATIENTS AND METHODS: We sequenced 22 cancer-related hotspot genes in TET tissues and matched normal tissues using Ampliseq Ion Torrent next-generation technology. Overall survival was evaluated using Kaplan-Meier methods and compared with log-rank tests...
2016: OncoTargets and Therapy
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