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https://www.readbyqxmd.com/read/29136732/-prognosis-factors-for-the-perineal-incision-complications-after-abdominoperineal-resection-for-low-rectal-cancer
#1
S Luo, J W Liang, H T Zhou, W Pei, Z X Zhou, Q Liu, X S Wang
Objective: To evaluate the prognosis factors affecting perineal incision complications after abdominoperineal resection (APR) for the low rectal cancer. Methods: This was a retrospective analysis of 151 consecutive patients with low rectal cancer undergoing APR between January and December 2013 at Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. The patients were comprised of 95 males and 56 females. The mean age of the patients was (57...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29136213/knottin-the-database-of-inhibitor-cystine-knot-scaffold-after-10-years-toward-a-systematic-structure-modeling
#2
Guillaume Postic, Jérôme Gracy, Charlotte Périn, Laurent Chiche, Jean-Christophe Gelly
Knottins, or inhibitor cystine knots (ICKs), are ultra-stable miniproteins with multiple applications in drug design and medical imaging. These widespread and functionally diverse proteins are characterized by the presence of three interwoven disulfide bridges in their structure, which form a unique pseudoknot. Since 2004, the KNOTTIN database (www.dsimb.inserm.fr/KNOTTIN/) has been gathering standardized information about knottin sequences, structures, functions and evolution. The website also provides access to bibliographic data and to computational tools that have been specifically developed for ICKs...
November 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29135409/double-inlay-plus-ventral-onlay-buccal-mucosa-graft-for-simultaneous-penile-and-bulbar-urethral-stricture
#3
Luciano A Favorito, Paulo P Conte, Ulisses G Sobrinho, Rodrigo G Martins, Tomas Accioly
OBJECTIVES: Buccal mucosa grafts and fascio-cutaneous flaps are frequently used in long anterior urethral strictures (1). The inlay and onlay buccal mucosa grafts are easier to perform, do not need urethral mobilization and generally have good long-term results (2-4). In the present video, we present a case where we used a double buccal mucosa graft technique in a simultaneous penile and bulbar urethral stricture. MATERIALS AND METHODS: A 54 year-old male patient was submitted to appendectomy where a urethral catheter was used for two days in May 2015...
November 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29135136/-structural-morphological-changes-of-the-connective-tissue-of-the-vaginal-mucosa-and-perineal-skin-in-women-with-stress-urinary-incontinence
#4
V N Pavlov, A G Yashchuk, A A Kazikhinurov, I I Musin, R M Zauinullina, V A Kulavskii, A A Kazikhinurova
AIM: To investigate the morphological and structural changes in the connective tissue of the vaginal mucosa and perineal skin in women with stress urinary incontinence. MATERIALS AND METHODS: From 2010 to 2013, 71 patients of reproductive age with stress incontinence were observed. The control group comprised 80 women, who also underwent biopsy of the vaginal mucosa and perineal skin. The sections of specimens were stained by Van Gieson, Mallory and Weigert. In immunohistochemical studies, rabbit antibodies specific for collagen types I, III, and IV were placed on each section...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29132933/long-term-follow-up-of-the-advance-%C3%A2-advancexp-%C3%A2-sling-what-are-the-surgeons-impressions-what-are-the-patients
#5
A Romero Hoyuela, L Reina Alcaina, E Izquierdo Morejon, A Rosino Sanchez, C Carrillo George, A Rivero Guerra, I Barcelo Bayonas, A Pardo Martinez, V Muñoz Guillermo, B Pietricica, T Fernandez Aparicio, G Hita Villaplana, B Miñana Lopez
OBJECTIVES: To analyse the safety, efficacy and quality of life of patients with male stress urinary incontinence after radical prostatectomy treated with the AdVance(®) and AdvanceXP(®) slings. PATIENTS AND METHOD: The study included 92 patients with stress urinary incontinence after radical prostatectomy treated with the AdVance(®) and AdVanceXP(®) sling between May 2008 and December 2015. A perineal repositioning test was performed in all cases with sphincter coaptation of≥1...
November 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29131385/rural-community-birth-maternal-and-neonatal-outcomes-for-planned-community-births-among-rural-women-in-the-united-states-2004-2009
#6
Elizabeth Nethery, Wendy Gordon, Marit L Bovbjerg, Melissa Cheyney
BACKGROUND: Approximately 22% of women in the United States live in rural areas with limited access to obstetric care. Despite declines in hospital-based obstetric services in many rural communities, midwifery care at home and in free standing birth centers is available in many rural communities. This study examines maternal and neonatal outcomes among planned home and birth center births attended by midwives, comparing outcomes for rural and nonrural women. METHODS: Using the Midwives Alliance of North America Statistics Project 2...
November 13, 2017: Birth
https://www.readbyqxmd.com/read/29130235/-a-meta-analysis-on-risk-factors-of-postoperative-perineal-wound-complications-after-abdominoperineal-resection-for-rectal-cancer
#7
Senqi Lu, Xiaofeng Chang, Xiaodong Yang, Decai Yu, Qigen Huang, Feng Wang
OBJECTIVE: To investigate the risk factors of postoperative perineal wound complications after abdominoperineal resection for rectal cancer. METHODS: The databases of Medline, Embase, Web of Science, Ovid, Cochrane Library, CBM, CNKI, VIP and WANFANG were searched for the studies of abdominoperineal resection up to October 2016. The quality of the included studies was assessed by using "Cochrane collaboration's tool for assessing risk of bias" and "the Newcastle-Ottawa Scale"...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29130229/-discovery-anatomy-and-clinical-significance-of-the-mesorectal-finish-line-of-total-mesorectal-excision
#8
Pan Chi, Xiaojie Wang, Guoxian Guan, Huiming Lin, Ying Huang, Weizhong Jiang
OBJECTIVE: To investigate the surgical endpoint of separation of mesorectum during total mesorectal excision (TME), suggesting the concept of "terminal line", in order to perform above separation better for middle-low rectal cancer. METHODS: Gross anatomy of mesorectum endpoint from 81 surgical specimens of low anterior resection (LAR, 5 to 6 cm of distance from low margin of cancer to anal edge) and 71 surgical specimens of abdominal perineal resection(APR, <5 cm of distance from low margin of cancer to anal edge) was observed...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29129039/combined-diet-and-exercise-interventions-for-preventing-gestational-diabetes-mellitus
#9
REVIEW
Emily Shepherd, Judith C Gomersall, Joanna Tieu, Shanshan Han, Caroline A Crowther, Philippa Middleton
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their infants in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM prevention, such as combined diet and exercise interventions. This is an update of a Cochrane review that was first published in 2015. OBJECTIVES: To assess the effects of diet interventions in combination with exercise interventions for pregnant women for preventing GDM, and associated adverse health consequences for the mother and her infant/child...
November 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29128910/allogeneic-ovarian-transplantation-using-immunomodulator-preimplantation-factor-pif-as-monotherapy-restored-ovarian-function-in-olive-baboon
#10
Michael Feichtinger, Eytan R Barnea, Atunga Nyachieo, Mats Brännström, S Samuel Kim
PURPOSE: Allogeneic ovarian transplantation may be an alternative in the future to oocyte donation in women with premature ovarian failure. The objectives of this study were to (a) evaluate allotransplantation feasibility for restoration of ovarian function and (b) assess efficacy of synthetic preimplantation factor (PIF) monotherapy as sole immune-acceptance regimen. METHODS: This is an experimental animal study using non-human primates (Papio anubis). Allogeneic orthotopic ovarian tissue transplantation was performed in two female olive baboons...
November 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29128647/a-mathematical-model-to-guide-genetic-engineering-of-photosynthetic-metabolism
#11
Giorgio Perin, Andrea Bernardi, Alessandra Bellan, Fabrizio Bezzo, Tomas Morosinotto
The optimization of algae biomass productivity in industrial cultivation systems requires genetic improvement of wild type strains isolated from nature. One of the main factors affecting algae productivity is their efficiency in converting light into chemical energy and this has been a major target of recent genetic efforts. However, photosynthetic productivity in algae cultures depends on many environmental parameters, making the identification of advantageous genotypes complex and the achievement of concrete improvements slow...
November 8, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29128409/breast-cancer-related-perceptions-and-practices-of-health-professionals-working-in-brazil-s-network-of-primary-care-units
#12
Benjamin D Hallowell, Douglas M Puricelli Perin, Eduardo J Simoes, Diana C Paez, Diana C Parra, Ross C Brownson, Mona Saraiya
In 2004 the Brazilian National Cancer Institute (INCA) established breast cancer screening guidelines for women in Brazil: annual clinical breast exam for women age 40-49 and biennial mammogram for women age 50-69. Healthcare provider's adherence to these guidelines is currently unknown. The objective of this study is to describe the perceptions and practices related to breast cancer screening among physicians, nurses, and health unit coordinators working in the network of primary healthcare units (HCUs) in Brazil...
November 8, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29121442/enteric-infections-in-young-children-are-associated-with-environmental-enteropathy-and-impaired-growth
#13
Christine Marie George, Vanessa Burrowes, Jamie Perin, Lauren Oldja, Shwapon Biswas, David Sack, Shahnawaz Ahmed, Rashidul Haque, Nurul Amin Bhuiyan, Tahmina Parvin, Sazzadul Islam Bhuyian, Mahmuda Akter, Shan Li, Gayathri Natarajan, Mohammad Shahnaij, Abu G Faruque, O Colin Stine
OBJECTIVE: To investigate the relationship between fecal contamination in child play spaces, enteric infections, environmental enteropathy (EE), and impaired growth among young children. METHODS: Prospective cohort study of 203 children 6-30 months of age in rural Bangladesh. Stool samples were analyzed by quantitative PCR for Shigella, Enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni, Giardia spp, and Cryptosporidium spp. Four fecal markers of intestinal inflammation were also measured: alpha-1-antitrypsin, myeloperoxidase, neopterin, and calprotectin...
November 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29119283/pudendal-nerve-injury-is-a-relatively-common-but-transient-complication-of-hip-arthroscopy
#14
REVIEW
Anthony Habib, Chloe E Haldane, Seper Ekhtiari, Darren de Sa, Nicole Simunovic, Etienne L Belzile, Olufemi R Ayeni
PURPOSE: Hip arthroscopy is emerging as the standard of care for conditions involving the hip, and has a unique set of complications. The purpose of this review was to identify (1) the crude rate of pudendal nerve injury following hip arthroscopy and (2) the specific factors leading to pudendal nerve injury. METHODS: MEDLINE, EMBASE, and PubMed were searched from database inception to October 2016. Patient demographics, indications, surgical technique, complication rates, treatment approaches, and rehabilitation strategies were extracted...
November 8, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29118550/-horrendoplasty-a-case-of-total-perineal-destruction-by-agricultural-implement
#15
Pedro Simoes de Oliveira, Tiago Ribeiro de Oliveira, David Martinho, Francisco Martins
Although posterior urethral injury occurs almost always in association with pelvic fracture, it may result from severe trauma to the perineum with its associated potential lethality and severe morbidity. Early primary endoscopic realignment over a urethral catheter can be attempted, although an immediate suprapubic tube placement remains the standard of care. Definitive treatment consists of elective open posterior anastomotic urethroplasty through a perineal approach. The authors present a 53-year-old man who sustained total, massive perineal destruction resulting from work accident with an agricultural implement...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29117727/crispoic-acid-a-new-compound-from-laelia-marginata-orchidaceae-and-biological-evaluations-against-parasites-human-cancer-cell-lines-and-zika-virus
#16
Andrezza C Belloto, Gredson K Souza, Paula C Perin, Ivania T A Schuquel, Silvana M O Santin, Lucas U R Chiavelli, Francielle P Garcia, Vanessa Kaplum, Jean H S Rodrigues, Débora B Scariot, Rodrigo Delvecchio, Erik Machado-Ferreira, Renato Santana Aguiar, Carlos A G Soares, Celso V Nakamura, Armando M Pomini
The phytochemical study of Laelia marginata (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid (1), together with six other known compounds (2-7). The new natural product was identified as a dimer of eucomic acid and was structurally characterised based upon 1D and 2D NMR and HRMS data. Biological assays with plant crude extract, fractions and isolated compounds were performed against two human cancer cell lines (Hela and Siha), and the tropical parasites Trypanosoma cruzi and Leishmania (Leishmania) amazonensis...
November 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29117015/racial-ethnic-differences-in-perineal-lacerations-in-a-diverse-urban-healthcare-system
#17
Amanda Williams, Beverly Gonzalez, Colleen Fitzgerald, Cynthia Brincat
OBJECTIVES: The aim of the study was o determine whether variations exist between races/ethnicities in perineal laceration at first vaginal delivery. METHODS: We assessed first vaginal deliveries greater than 35 weeks gestation, for a four-year period, in our diverse urban healthcare system. Predictor variable was race/ethnicity with outcome variable of none, first-, second-, third-, or fourth-degree perineal laceration. Race and ethnicity were self-reported and combined into one variable to facilitate analysis...
November 7, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29112562/initiation-of-a-transanal-total-mesorectal-excision-program-at-an-academic-training-program-evaluating-patient-safety-and-quality-outcomes
#18
Justin A Maykel, Uma R Phatak, Pasithorn A Suwanabol, Andrew T Schlussel, Jennifer S Davids, Paul R Sturrock, Karim Alavi
BACKGROUND: Short-term results have shown that transanal total mesorectal excision is safe and effective for patients with mid to low rectal cancers. Transanal total mesorectal excision is considered technically challenging; thus, adoption has been limited to a few academic centers in the United States. OBJECTIVE: The aim of this study is to describe outcomes after the initiation of a transanal total mesorectal excision program in the setting of an academic colorectal training program...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29110729/penile-metastasis-from-rectal-adenocarcinoma-a-case-report
#19
Boubacar Efared, Gabrielle Atsame Ebang, Soufiane Tahirou, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Aboubakry Sow, Nawal Hammas, Moulay H Farih, Laila Chbani, Hinde El Fatemi
BACKGROUND: Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis. CASE PRESENTATION: We report a case of a 46-year-old Arabic man who presented with erectile dysfunction and painful induration of the penile root. Eight months ago, he had undergone abdomino-perineal resection for rectal adenocarcinoma after neo-adjuvant chemotherapy...
November 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29108322/the-predictive-efficacy-of-hypoechoic-lesion-in-ultrasound-for-prostate-cancer-in-chinese-people-five-year-experience-in-a-moderated-10-core-transperineal-prostate-biopsy-procedure
#20
Tian Yang, Limin Zhang, Yixin Chen, Yehua Cai, Haowen Jiang, Qiang Ding
We aim to investigate the predictive efficacy of hypoechoic lesion for prostate cancer at different levels of serum PSA in the procedure of transrectal ultrasound guided 10-core trans-perineal prostate biopsy (TP-PBx). In this study, we collected clinical parameters involving age, digital rectal examination (DRE), PSA, prostate volume, pathological diagnosis, Gleason score, novel Gleason group, and numbers of positive cores from 856 patients who had elevated level of PSA above 4 ng/ml or susceptible nodule of prostate gland in DRE received the moderated 10-core TP-PBx procedure...
October 3, 2017: Oncotarget
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