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Anterior Ischemic Optic Neuropathy

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https://www.readbyqxmd.com/read/29451992/optical-coherence-tomography-angiography-of-the-peripapillary-retina-in-normal-tension-glaucoma-and-chronic-nonarteritic-anterior-ischemic-optic-neuropathy
#1
Rodolfo Mastropasqua, Luca Agnifili, Enrico Borrelli, Vincenzo Fasanella, Lorenza Brescia, Luca Di Antonio, Leonardo Mastropasqua
PURPOSE: To analyze the retinal radial peripapillary capillary (RPC) network in normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) eyes using optical coherence tomography angiography (OCTA). MATERIAL AND METHODS: Twenty-two patients with NTG, 22 patients with unilateral chronic NAION, and 23 age-matched controls were enrolled. Patients underwent OCTA to obtain en face angiograms of the peripapillary region. The main outcome measures were as follows: (1) the whole en face image perfusion density (WPD) and (2) the circumpapillary perfusion density (CPD)...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29429414/rapidly-progressive-neovascular-glaucoma-following-coronary-artery-bypass-graft-surgery-in-a-patient-with-type-1-diabetes-mellitus-a-case-report
#2
Vasant Raman, Rosemary Lambley
BACKGROUND: Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Onset of neovascular glaucoma with rapid progression to blindness within a few weeks of a successful coronary artery bypass graft procedure is not known with this clinical entity...
February 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29338755/hyperhomocysteinemia-in-bilateral-anterior-ischemic-optic-neuropathy-after-conventional-coronary-artery-bypass-graft-a-case-report
#3
A Niro, G Sborgia, A Sborgia, G Alessio
BACKGROUND: The incidence of anterior ischemic optic neuropathy after coronary artery bypass graft procedures ranges from 1.3 to 0.25%. The mechanisms of anterior ischemic optic neuropathy after cardiovascular procedures remain undefined but many systemic and related-to-surgery risk factors could underlie anterior ischemic optic neuropathy. In this case, we report a rare presentation of a bilateral anterior ischemic optic neuropathy after coronary artery bypass graft and speculate on the preoperative hyperhomocysteinemia as an independent risk factor for anterior ischemic optic neuropathy...
January 17, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29330063/risk-of-ischemic-kidney-injury-in-patients-with-nonarteritic-anterior-ischemic-optic-neuropathy-a-nationwide-population-based-study
#4
Ju-Yeun Lee, Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To investigate the risk of acute tubular necrosis (ATN) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN: Population-based cohort study METHODS: This is a nationwide, population-based, retrospective study using data from the Korean national health claims database from 2011 through 2015. Patients with NAION and randomly selected control subjects from the entire Korean population were enrolled. A log rank analysis was used to evaluate a risk of ATN in the group of patients with NAION (study group) compared to an age-, sex-, and comorbidities-matched control group...
January 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29320503/pattern-of-peripapillary-capillary-density-loss-in-ischemic-optic-neuropathy-compared-to-that-in-primary-open-angle-glaucoma
#5
Masoud Aghsaei Fard, Yanin Suwan, Sasan Moghimi, Lawrence S Geyman, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thickness. METHODS: 31 chronic NAION (>6 months after the acute event) and unaffected fellow eyes (31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes (46 healthy subjects) were imaged with a commercial optical coherence tomography angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic institutions...
2018: PloS One
https://www.readbyqxmd.com/read/29260067/severe-bilateral-optic-nerve-and-retinal-hypoperfusion-in-a-patient-with-acute-respiratory-distress-syndrome-and-septic-shock
#6
Wei Gui, Erika Tanaka Friesen, Laura Bonelli, Ye Elaine Wang, Anthony C Arnold
Purpose: To report a case of bilateral central retinal artery occlusion with both anterior and posterior ischemic optic neuropathy. Observations: A 65-year-old Caucasian woman presented with acute respiratory distress syndrome and septic shock. After treatment with vasopressors and prolonged prone positioning, she was noted to be bilaterally completely blind on hospitalization day 12. Evaluation revealed evidence of bilateral central retinal artery occlusion and bilateral ischemic optic neuropathy...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260058/a-case-of-non-arteritic-anterior-ischemic-optic-neuropathy-after-completion-of-harvoni-therapy
#7
Niranjan Manoharan, Prem Sagar Subramanian
Purpose: To report the first reported case of non-arteritic anterior ischemic optic neuropathy (NAION) associated with the use of Harvoni (Gilead Sciences, Foster City, CA, USA), a newly approved treatment for Hepatitis C. Observations: We report a case of NAION in a hepatitis C patient who completed Harvoni therapy just prior to presentation. Harvoni was suspected to be the causative agent given a lack of NAION risk factors in an otherwise healthy young patient...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29231347/-study-on-electroacupuncture-along-the-visual-conductive-pathway-for-ocular-cell-apoptosis-in-anterior-ischemic-optic-neuropathy
#8
Ying Wang, Hui Guo, Zide Zhao, Lina Yu, Peng Bai
OBJECTIVE: To study the protective effect of electroacupuncture (EA) along the visual conductive pathway for the optic nerve tissue of anterior ischemic optic neuropathy (AION) in terms of the structure and apoptosis. METHODS: The AION model of right eye was established with laser in 48 New Zealand white ear rabbits. All rabbits were randomly divided into a model group, an acupuncture group and an acupuncture combined with EA group, 16 rabbits in each one. Other 16 normal left eyes were selected as a blank group...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29227256/-psychogenic-factors-in-the-pathogenesis-of-anterior-ischemic-optic-neuropathy-review
#9
B Ahmadyarova, Y Shusterov, M Lyubchenko
The purpose of this systematic review is to describe the influence of psychogenic factors on the pathogenesis and course of anterior ischemic optic neuropathy (AION). Analysis of randomized clinical trials published in the journal indexed in PubMed in the period from 1978 to 2016, devoted to the study of the influence of various factors on the epidemiology, pathogenesis and course of AION. The review of the literature presents basic information on the psychogenic factors that affect the course of AION and the areas of clinical application of the data under study...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29222573/incidence-and-causes-of-overdiagnosis-of-optic-neuritis
#10
Leanne Stunkel, Nathan H Kung, Bradley Wilson, Collin M McClelland, Gregory P Van Stavern
Importance: Diagnostic error is an important source of medical error. Overdiagnosis of optic neuritis may prompt unnecessary and costly diagnostic tests, procedures, and treatments. Objective: To assess the incidence of and characterize factors contributing to overdiagnosis of acute optic neuritis. Design, Setting, and Participants: In this retrospective clinic-based cross-sectional study of new patient encounters, 122 patients referred for acute optic neuritis at a university-based Midwestern neuro-ophthalmology clinic between January 2014 and October 2016 were studied...
December 7, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#11
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29120976/case-report-masquerading-large-vessel-giant-cell-arteritis
#12
Paul Jacquier, Raphael Wuarin, Carlo Chizzolini, Gabriele Thumann, Heimo Steffen, Argyrios Chronopoulos
SIGNIFICANCE: Large-vessel giant cell arteritis (GCA) can be a diagnostic dilemma for the eye care provider because it may not involve the typical cranial arteries. When any of its potential ocular complications are diagnosed, it is important to consider this unusual form of GCA. PURPOSE: To report an unusual ophthalmic presentation of large-vessel GCA with sequential bilateral anterior ischemic optic neuropathy and branch retinal artery occlusion. METHODS: A 65-year-old previously healthy woman experienced sequential bilateral anterior ischemic optic neuropathy with branch retinal artery occlusion in the absence of other signs and symptoms suggestive of cranial GCA...
November 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29107469/diseases-of-the-retina-and-the-optic-nerve-associated-with-obstructive-sleep-apnea
#13
REVIEW
Marielle Mentek, Florent Aptel, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pepin, Christophe Chiquet
Many associations between ocular disorders and obstructive sleep apnea (OSA) have been studied, such as nonarteritic anterior ischemic optic neuropathy, glaucoma, papilledema, retinal vein occlusion, eyelid hyperlaxity, lower-eyelid ectropion and recurrent corneal erosions. The objective of this review is to synthetize the possible vascular disorders of the retina and the optic nerve associated with sleep apnea patients and to discuss the underlying pathophysiological hypotheses. Main mechanisms involved in the ocular complications of OSA are related to intermittent hypoxia, sympathetic system activation, oxidant stress, and deleterious effects of endothelin 1...
May 29, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29065678/bilateral-optic-neuropathy-related-to-severe-anemia-in-a-patient-with-alcoholic-cirrhosis-a-case-report-and-review-of-the-literature
#14
Lisa Humbertjean-Selton, Jérôme Selton, Nolwenn Riou-Comte, Jean-Christophe Lacour, Gioia Mione, Sébastien Richard
Anemia appears frequently in patients with alcoholic liver disease (ALD) but has never been linked to bilateral nonarteritic anterior ischemic optic neuropathy (NAION). A 65-year-old woman with a medical history of alcoholic cirrhosis was admitted for bilateral NAION. On admission, she was found to have a low arterial pressure and severe normocytic anemia (48 g/L). The anemia was related to chronic bleeding due to antral gastritis along with other factors associated with ALD. The applied treatment consisted of urgent transfusion followed by high doses of proton-pump inhibitors, iron and vitamin supplementation, and support in lifestyle measures...
October 25, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29049405/differences-in-pupillary-light-reflex-between-optic-neuritis-and-ischemic-optic-neuropathy
#15
Yung Ju Yoo, Jeong-Min Hwang, Hee Kyung Yang
OBJECTIVES: To determine the differences in pupillary light reflex (PLR) between the acute and chronic phases of optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: The study included 30 patients with ON and 22 patients with NAION whose PLR were measured by a dynamic pupillometer (PLR-200; NeurOptics Inc., Irvine, USA). Age-matched controls included 58 healthy individuals with normal vision and optic nerve function. Pupil diameters, latency, constriction ratio, constriction velocity and dilation velocity were noted...
2017: PloS One
https://www.readbyqxmd.com/read/29042528/-a-case-of-ruptured-anterior-communicating-artery-aneurysm-with-visual-field-defects-and-deteriorating-to-severe-vision-loss
#16
Kazuki Sakakura, Go Ikeda, Yasunobu Nakai, Noriyuki Watanabe, Masanari Shiigai, Kazuya Uemura, Tetsuya Yamamoto, Akira Matsumura
Although Terson's syndrome is a well-known cause of vision loss due to intracerebral aneurysm rupture, optic nerve neuropathy can also occur because of other causes. Here, we report such a case, i.e., a ruptured anterior communicating artery aneurysm accompanied by vision loss and visual field disturbances due to a cause other than Terson's syndrome. A 47-year-old man presented with right superior altitudinal hemianopia. Computed tomography (CT) showed subarachnoid hemorrhage (SAH), and three-dimensional CT angiography revealed an anterior communicating artery aneurysm...
October 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29033621/nonarteritic-anterior-ischemic-optic-neuropathy-cause-effect-and-management
#17
REVIEW
Shauna Berry, Weijie V Lin, Ama Sadaka, Andrew G Lee
Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common form of ischemic optic neuropathy and the second most common optic neuropathy. Patients are generally over the age of 50 years with vasculopathic risk factors (eg, diabetes mellitus, hypertension, and obstructive sleep apnea). The exact mechanism of NAION is not fully understood. In addition, several treatment options have been proposed. This article summarizes the current literature on the diagnosis, treatment, and management of NAION...
2017: Eye and Brain
https://www.readbyqxmd.com/read/29024675/tempo-ral-was-the-heart-of-the-matter
#18
Francesco Pellegrini, Daniele Cirone, Piernicola Machin, Rod Foroozan
A 71-year-old woman was admitted with fever, headache, and weight loss associated with elevated inflammatory markers. She developed acute bilateral ophthalmoplegia and asymmetrical ptosis, rapidly followed by anterior ischemic optic neuropathy. Although the first temporal artery biopsy was negative, contralateral temporal artery biopsy revealed features consistent with giant cell arteritis. Even while under steroid therapy, she died a few days later from myocardial infarction. Acute bilateral complete ophthalmoplegia is a rare presentation of a limited number of possible diseases...
October 10, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29016409/anterior-ischemic-optic-neuropathy-due-to-calciphylaxis
#19
Magne S Sivertsen, Erik H Strøm, Kim M A Endre, Øystein K Jørstad
A 72-year-old woman experienced anterior ischemic optic neuropathy in her left eye. The funduscopic and fluorescein angiographic findings were strongly suggestive of giant cell arteritis. Temporal artery biopsy revealed extensive calcification in the vessel wall consistent with calciphylaxis. This unusual disorder should be considered in the differential diagnosis of anterior ischemic optic neuropathy, particularly the arteritic form.
October 6, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28986994/microvasculature-dropout-detected-by-the-optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#20
Yi Song, Jing-Yu Min, Lei Mao, Yuan-Yuan Gong
OBJECTIVE: To investigate microcirculation characteristics of peripapillary superficial retina and optic disc in eyes with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA). METHODS: Forty-one eyes of 30 NAION patients and 30 eyes of 30 normal subjects were evaluated with OCTA (AngioVue, Optovue). The whole vessel density, inside disc vessel density, peripapillary vessel density, and vessel densities based on the sectorial division in the nerve head mode peripapillary superficial retina and RPC mode optic disc were measured respectively...
October 7, 2017: Lasers in Surgery and Medicine
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