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Anterior Ischemic Optic Neuropathy

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https://www.readbyqxmd.com/read/28029908/pathology-of-ischemic-optic-neuropathy
#1
Hershel R Patel, Curtis E Margo
Ischemic optic neuropathy (ION) describes a state of hypoxic injury of the optic nerve. Clinically, ION is divided into anterior and posterior forms defined by the presence or absence of optic disc swelling, respectively. It is further classified as arteritic when secondary to vasculitis, and nonarteritic when not. The site of vascular occlusion for anterior ION from giant cell arteritis is the short posterior ciliary arteries, but mechanical vascular obstruction does not play a role in most nonarteritic cases...
January 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28017420/comparison-of-visual-outcomes-of-nonarteritic-anterior-ischemic-optic-neuropathy-in-patients-with-and-without-diabetes-mellitus
#2
Srilakshmi Sharma, Sarah Kwan, Katherine A Fallano, Jiangxia Wang, Neil R Miller, Prem S Subramanian
PURPOSE: Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN: Case-control study. PARTICIPANTS: All 231 patients with NAION seen by the Neuro-Ophthalmology Service, Wilmer Eye Institute, between 2002 and 2011 were screened for study inclusion...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27998456/-temporal-and-spatial-characteristics-of-rgc-death-and-axon-degeneration-in-the-rat-model-of-nonarteritic-anterior-ischemic-optic-neuropathy
#3
Y W Wang, T Chen, J Ma, Y Zhong
Objective: To investigate the temporal and spatial characteristics of retinal ganglion cell (RGC) death and axon degeneration in the rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). Methods: Experimental study. The model of rNAION was induced by directly illuminating the optic nerve head with laser, after intravenous infusion with the photosensitizing agent rose Bengal. Seventy-one SD rats were randomly divided into five groups: 1-week (n=14), 2-week (n=14), 4-week (n=15) , 8-week (n=16) model group and the normal control group (n=12)...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27984351/structural-and-functional-analyses-in-nonarteritic-anterior-ischemic-optic-neuropathy-optical-coherence-tomography-angiography-study
#4
Masayuki Hata, Akio Oishi, Yuki Muraoka, Kazuaki Miyamoto, Kentaro Kawai, Satoshi Yokota, Masahiro Fujimoto, Manabu Miyata, Nagahisa Yoshimura
BACKGROUND: Retinal and optic disc perfusion in nonarteritic anterior ischemic optic neuropathy (NAION) is incompletely understood. Our aim was to investigate the characteristics of the microvascular structures at the peripapillary area and optic disc, and their associations with retinal structure and function in patients with NAION. METHODS: We conducted a prospective, observational case series study. Thirty-four eyes, consisting of 15 NAION eyes and 19 normal eyes, were included...
December 14, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27984350/nonarteritic-anterior-ischemic-optic-neuropathy-and-erectile-dysfunction-drugs-is-there-an-elephant-in-the-bedroom
#5
Joshua M Kruger, Howard D Pomeranz
No abstract text is available yet for this article.
December 14, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27984025/post-cataract-surgery-optic-neuropathy-pcson-prevalence-incidence-temporal-relationship-and-fellow-eye-involvement
#6
Ahmadreza Moradi, Sivashakthi Kanagalingam, Marie Diener-West, Neil R Miller
PURPOSE: To reassess the prevalence and incidence of post-cataract surgery optic neuropathy (PCSON) in the modern era. DESIGN: Retrospective cohort study. SETTING: Single center, tertiary care practice. STUDY POPULATION: All patients with a diagnosis of non-arteritic anterior ischemic optic (NAION) seen in the Wilmer Eye Network system between January 1, 2010 and December 31, 2014 were included. Inclusion was based on: (1) a history of an acute unilateral decrease in vision, (2) a visual field defect consistent with NAION, (3) a relative afferent pupillary defect, (4) observed optic disc swelling, and 5) no other etiology being found...
October 27, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27982219/nonarteritic-anterior-ischemic-optic-neuropathy-following-pars-plana-vitrectomy-for-macular-hole-treatment-case-report
#7
Leonardo Provetti Cunha, Luciana Virgínia Ferreira Costa Cunha, Carolina Ferreira Costa, Mário Luiz Ribeiro Monteiro
Herein, we report a case of nonarteritic anterior ischemic optic neuropathy (NAION) following uneventful pars plana vitrectomy for macular hole treatment. A 56-year-old previously healthy woman presented with a full-thickness macular hole in right eye (OD) and small cup-to-disc ratios in both eyes. Five days after surgery, she noticed sudden painless loss of vision in OD and was found to have an afferent pupillary defect and intraocular pressure of 29 mmHg. Fundus examination showed right optic disc edema and the resolution of a macular hole with an inferior altitudinal visual field defect...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27938958/anterior-ischemic-optic-neuropathy-and-hematologic-malignancy-a-systematic-review-of-case-reports-and-case-series
#8
David Cordeiro Sousa, Filipe Brogueira Rodrigues, Gonçalo Duarte, Fátima Campos, Filomena Pinto, A Vaz-Carneiro
OBJECTIVE: Demographic and clinical characteristics associated with nonarteritic anterior ischemic optic neuropathy (NAION) are well described. Patients with hematologic neoplasms may share some of these characteristics, and it may be useful clinically to better understand this set of patients. Our objective is to review systematically the characteristics of patients with both hematologic malignancies and NAION. DESIGN: Systematic review. PARTICIPANTS: Patients with NAION diagnosis related in time to a hematologic neoplasm...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27914988/imaging-of-macrophage-dynamics-with-optical-coherence-tomography-in-anterior-ischemic-optic-neuropathy
#9
Despina Kokona, Nathanael U Häner, Andreas Ebneter, Martin S Zinkernagel
Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100'000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events occurring at the level of the optic nerve head (ONH) would be important to design future therapeutic strategies...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27914839/late-in-the-bag-intraocular-lens-dislocation-a-randomized-clinical-trial-comparing-lens-repositioning-and-lens-exchange
#10
Olav Kristianslund, Marianne Råen, Atle E Østern, Liv Drolsum
PURPOSE: To compare the efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN: Prospective, randomized, parallel-group surgical trial. PARTICIPANTS: Patients referred to Oslo University Hospital (tertiary referral center). METHODS: We randomly assigned 104 patients (104 eyes) either to IOL repositioning by scleral suturing (n = 54) or to IOL exchange with retropupillary fixation of an iris-claw IOL (n = 50)...
November 30, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27911358/the-rodent-model-of-nonarteritic-anterior-ischemic-optic-neuropathy-rnaion
#11
Yan Guo, Zara Mehrabian, Steven L Bernstein
Nonarteritic anterior ischemic optic neuropathy (NAION) is a focal ischemic lesion of the optic nerve that affects 1/700 individuals throughout their lifetime. NAION results in optic nerve edema, selective loss of the retinal ganglion cell neurons (RGCs) and atrophy of the optic nerve. A rodent model of NAION that expresses most NAION features and sequelae has been developed, which is applicable to both rats and mice. This model utilizes a focal laser application of 532 nm wavelength to illuminate a photoactive dye, Rose Bengal (RB), to cause capillary damage and leakage at the targeted anterior optic nerve (the laminar region)...
November 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27886893/erectile-dysfunction-agents-and-nonarteritic-anterior-ischemic-optic-neuropathy
#12
REVIEW
Howard D Pomeranz
Phosphodiesterase-5 inhibitors (PDE5I) are used for treatment of erectile dysfunction and pulmonary arterial hypertension and have been implicated as a causative factor for development of nonarteritic anterior ischemic optic neuropathy (NAION). Controversy remains regarding a cause and effect between PDE5I use and NAION because the mechanism by which NAION occurs is still not well understood. Because neuro-ophthalmologists have accepted that there is a potential relationship between ingestion of the PDE5I class of medications and NAION, the neuro-ophthalmologist should inquire about PDE5I use when evaluating a patient with a new diagnosis of NAION, and counsel patients regarding the implication of continued use of PDE5I...
February 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/27886887/new-treatments-for-nonarteritic-anterior-ischemic-optic-neuropathy
#13
REVIEW
Rod Foroozan
Despite increasing knowledge about the risk factors and clinical findings of nonarteritic anterior ischemic optic neuropathy (NAION), the treatment of this optic neuropathy has remained limited and without clear evidence-based benefit. Historical treatments of NAION are reviewed, beginning with the Ischemic Optic Neuropathy Decompression Trial. More recent treatments are placed within the historical context and illustrate the need for evidence-based therapy for ischemic optic neuropathy.
February 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/27871391/trying-to-understand-nonarteritic-anterior-ischemic-optic-neuropathy-through-big-data
#14
EDITORIAL
John Chen
No abstract text is available yet for this article.
December 2016: Ophthalmology
https://www.readbyqxmd.com/read/27855129/temporal-arteritis-with-arteritic-anterior-ischemic-optic-neuropathy-is-bilateral-until-proven-otherwise-response
#15
Neil R Miller, Tin Yan Alvin Liu
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27855128/giant-cell-arteritis-with-arteritic-anterior-ischemic-optic-neuropathy-is-bilateral-until-proven-otherwise
#16
Nandini Singh, Adarsh George, Jeremy Tan, Shaun Y P Ewe, Ian C Francis
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27843231/anterior-ischemic-optic-neuropathy-following-dengue-fever
#17
Reshma Ramakrishnan, Saurabh Shrivastava, Shrikant Deshpande, Priyanka Patkar
Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; and maculopathies, haemorrhage, and oedema. However anterior ischemic optic neuropathy is a rare presentation. Optic nerve ischemia most frequently occurs at the optic nerve head, where structural crowding of nerve fibers and reduction of the vascular supply may combine to impair perfusion to a critical degree and produce optic disc oedema...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27785596/the-diagnostic-accuracy-of-chromatic-pupillary-light-responses-in-diseases-of-the-outer-and-inner-retina
#18
Paul Richter, Helmut Wilhelm, Tobias Peters, Holger Luedtke, Anne Kurtenbach, Herbert Jaegle, Barbara Wilhelm
PURPOSE: To compare the chromatic pupillary light responses (PLR) in healthy subjects with those from patients with diseases of the outer or inner retina under various stimulus conditions, and to ascertain the parameters required to optimally distinguish between disease and control groups. METHODS: Fifteen patients with retinitis pigmentosa (RP), 19 patients with optic nerve disease (ON), and 16 healthy subjects were enrolled in this prospective study. ON included optic neuritis (NNO) and non-arteritic anterior ischemic optic neuropathy (NAION)...
October 26, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27761294/neutrophil-to-lymphocyte-ratio-and-non-arteritic-anterior-ischemic-optic-neuropathy
#19
Murat Afyon, Akın Çakır
No abstract text is available yet for this article.
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27689029/clinical-usefulness-of-spectral-domain-optical-coherence-tomography-in-glaucoma-and-naion
#20
REVIEW
Tae Hee Lee, Hwan Heo, Sang Woo Park
The development of optical coherence tomography (OCT) has changed the clinical management of ophthalmic diseases by furthering the understanding of pathogenesis, as well as improving the monitoring of their progression and assisting in quantifying the response to treatment modalities in ophthalmic diseases. Initially, the two-dimensional configuration of the optic nerve head (ONH) and the thickness of the retinal nerve fiber layer (RNFL) were the main OCT structural parameters used in clinical management of optic nerve diseases...
September 2016: Chonnam Medical Journal
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