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Anterior Ischemic Optic Neuropathy

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https://www.readbyqxmd.com/read/28431433/experimental-anterior-ischemic-optic-neuropathy-in-diabetic-mice-exhibited-severe-retinal-swelling-associated-with-vegf-elevation
#1
Ming-Hui Sun, Mohammad Ali Shariati, Yaping Joyce Liao
Purpose: Diabetes mellitus (DM) is one of the most important risk factors for nonarteritic anterior ischemic optic neuropathy (AION). In this study, we investigated for the first time the impact of experimental AION in a DM model. Methods: We induced a photochemical thrombosis model of AION after streptozotocin-induced DM and performed serial optical coherence tomography (OCT), morphometric analyses, and VEGF levels in the retina and sera. Results: Compared with non-DM animals, experimental AION in DM mice led to significantly greater retinal swelling on day 1 and worse thinning at week 3 on OCT measurements...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28430051/reversible-postoperative-blindness-caused-by-bilateral-status-epilepticus-amauroticus-following-thoracolumbar-deformity-correction-case-report
#2
Tarik F Ibrahim, Rochelle T Sweis, Russ P Nockels
Postoperative vision loss (POVL) is a devastating complication and has been reported after complex spine procedures. Anterior ischemic optic neuropathy and posterior optic neuropathy are the 2 most common causes of POVL. Bilateral occipital lobe seizures causing complete blindness are rare and have not been reported as a cause of POVL after spine surgery with the patient prone. The authors report the case of a 67-year-old man without a history of seizures who underwent a staged thoracolumbar deformity correction and developed POVL 6 hours after surgery...
April 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28427356/postural-effects-on-intraocular-pressure-and-ocular-perfusion-pressure-in-patients-with-non-arteritic-anterior-ischemic-optic-neuropathy
#3
Jee Myung Yang, Sang Woo Park, Yong Sok Ji, Jaeryung Kim, Chungkwon Yoo, Hwan Heo
BACKGROUND: To investigate postural effects on intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with non-arteritic ischemic optic neuropathy (NAION). METHODS: IOP and blood pressure (BP) were measured in 20 patients with unilateral NAION 10 min after changing to each of the following positions sequentially: sitting, supine, right lateral decubitus position (LDP), supine, left LDP, and supine. IOP was measured using a rebound tonometer and OPP was calculated using formulas based on mean BP...
April 20, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28400888/macular-evaluation-w%C3%A4-th-spectral-domain-type-optic-coherence-tomography-in-eyes-with-acute-nonarteritic-ischemic-optic-neuropathy-at-the-presentation-visit
#4
Oya Donmez, Gamze Kocaoglu, Aylin Yaman, Meltem Soylev Bajin, Ali Osman Saatci
PURPOSE: To evaluate the macula with spectral domain type optic coherence tomography (OCT) in eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION) at the presentation visit. METHODS: Medical charts of the 133 patients who received the diagnosis of acute NAION between January 2008 and July 2014 at the Neuro-ophthalmology unit of Dokuz Eylul University were reviewed retrospectively. Sixtythree patients within 30 days of symptom onset with available baseline spectral domain type macular OCT were included in this study...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28395906/-oct-angiography-and-choroidal-ischemia-related-to-arteritic-anterior-ischemic-optic-neuropathy
#5
M-B Rougier, M-N Delyfer, J-F Korobelnik
No abstract text is available yet for this article.
April 7, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28389774/takayasu-arteritis-presenting-as-isolated-anterior-ischemic-optic-neuropathy
#6
Guohong Tian, Qian Chen, Wenji Wang
Takayasu arteritis (TA) is a systemic vasculitis of unknown etiology that affects the aorta and its primary branches or large arteries in the proximal upper or lower extremities. Ocular manifestations of TA include microaneurysm formation, small-vessel dilation, arteriovenous anastomosis, retinal ischemia, and neovascular glaucoma. We herein report a case involving a 23-year-old Asian woman who presented with isolated acute anterior ischemic optic neuropathy and was initially misdiagnosed with optic neuritis...
April 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28387764/crowded-optic-nerve-head-evaluation-with-optical-coherence-tomography-in-anterior-ischemic-optic-neuropathy
#7
S Moghimi, M Afzali, M Akbari, K B Ebrahimi, A Khodabande, A R Yazdani-Abyaneh, S N H Ghafouri, P Coh, S Okhravi, M A Fard
PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups...
April 7, 2017: Eye
https://www.readbyqxmd.com/read/28367045/neutrophil-to-lymphocyte-ratio-in-patients-with-nonarteritic-anterior-ischemic-optic-neuropathy
#8
Alime Gunes, Musa Yigit, Levent Tok, Ozlem Tok
PURPOSE: To evaluate the neutrophil to lymphocyte ratio (NLR) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: We investigated 112 subjects comprising 56 patients with NAION and 56 healthy controls at Süleyman Demirel University. Complete blood count, demographic, and clinic data from NAION patients were evaluated in this study. The NLR was calculated in all individuals and compared between the patient and control groups. Cut-off values were also determined...
April 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28365911/visual-field-defects-of-the-contralateral-eye-of-non-arteritic-ischemic-anterior-optic-neuropathy-are-they-related-to-sleep-apnea
#9
Florent Aptel, Nischal Aryal-Charles, Renaud Tamisier, Jean-Louis Pépin, Antoine Lesoin, Christophe Chiquet
PURPOSE: To evaluate whether obstructive sleep apnea (OSA) is responsible for the visual field defects found in the fellow eyes of patients with non-arteritic ischemic optic neuropathy (NAION). METHODS: Prospective cross-sectional study. The visual fields of the fellow eyes of NAION subjects with OSA were compared to the visual fields of control OSA patients matched for OSA severity. All patients underwent comprehensive ophthalmological and general examination including Humphrey 24...
April 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28336289/prospective-case-crossover-study-investigating-the-possible-association-between-nonarteritic-anterior-ischemic-optic-neuropathy-naion-and-phosphodiesterase-type-5-inhibitor-pde5i-exposure
#10
Evelyn M Flahavan, Hu Li, Komal Gupte-Singh, Rosemary T Rizk, Dustin D Ruff, Jennie Lin Francis, Kraig S Kinchen
OBJECTIVE: To evaluate association between intermittent phosphodiesterase type 5 inhibitor (PDE5i) exposure and risk of acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) using a case-crossover design. METHODS: Male adults with suspected NAION were enrolled at 41 US ophthalmology sites from 2010-2015 and interviewed regarding risk factors for NAION, medical history, and PDE5i use before NAION onset (index of onset [IDO]). An adjudication committee confirmed NAION cases...
March 20, 2017: Urology
https://www.readbyqxmd.com/read/28316838/retinal-vessel-density-in-optical-coherence-tomography-angiography-in-optic-atrophy-after-nonarteritic-anterior-ischemic-optic-neuropathy
#11
Chun-Hsiu Liu, Ling-Yuh Kao, Ming-Hui Sun, Wei-Chi Wu, Henry Shen-Lih Chen
Aims. To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between normal and optic atrophy after nonarteritic anterior ischemic optic neuropathy (NAION) subjects. Design. This prospective observational study was conducted between July 2015 and August 2016 at the ophthalmology outpatient department of a referral center in Taiwan. Peripapillary (4.5 × 4.5 mm) and parafoveal (6 × 6 mm) OCT-A scans were acquired. Measurements of the peripapillary region were obtained in two areas: (1) circumpapillary vessel density (cpVD) and (2) whole enface image vessel density (wiVD)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28303068/high-dose-intravenous-pulse-steroid-therapy-for-optic-disc-swelling-and-subretinal-fluid-in-non-arteritic-anterior-ischemic-optic-neuropathy
#12
Kei Takayama, Hiroki Kaneko, Shu Kachi, Eimei Ra, Yasuki Ito, Hiroko Terasaki
Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease with microvascular abnormality that causes acute optic disc swelling (ODS) and, in severe cases, subretinal fluid (SRF) accumulation. ODS causes compartment syndrome and subsequent axonal degeneration and loss of retinal ganglion cells by apoptosis. No treatment modalities have been effective, although some cases improved after the intake of oral systemic steroids. We reported a case of a 72-year-old man who was referred due to a visual defect in the right eye...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28302535/aqueous-humor-cytokines-in-patients-with-acute-non-arteritic-anterior-ischemic-optic-neuropathy-naion
#13
Jonathan A Micieli, Cindy Lam, Kinda Najem, Edward A Margolin
PURPOSE: To measure and compare the cytokine concentrations in the aqueous humor of patients with acute non-arteritic anterior ischemic optic neuropathy (NAION) and normal age-related cataract controls. DESIGN: Prospective, comparative observational study. METHODS: Aqueous humor samples were obtained in 10 patients with acute NAION (within 14 days of symptom onset) and 15 control patients with age-related cataract. The levels of 6 cytokines [vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-2, IL-6, and IL-8] were determined using a multiplex bead immunoassay...
March 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28301863/optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#14
Emily Wright Mayes, Emily D Cole, Sabin Dang, Eduardo A Novais, Laurel Vuong, Carlos Mendoza-Santiesteban, Jay S Duker, Thomas R Hedges
BACKGROUND: Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016...
March 15, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28297028/early-methylprednisolone-treatment-can-stabilize-the-blood-optic-nerve-barrier-in-a-rat-model-of-anterior-ischemic-optic-neuropathy-raion
#15
Tzu-Lun Huang, Yao-Tseng Wen, Chung-Hsing Chang, Shu-Wen Chang, Kuan-Hung Lin, Rong-Kung Tsai
Purpose: We investigated whether methylprednisolone (MP) treatment halting retinal ganglion cell (RGC) death and having anti-inflammatory effect over a narrow therapeutic window affects the integrity of the blood-optic nerve barrier (BOB) in a rat model of ischemic optic neuropathy (rAION). Methods: The optic nerve (ON) vascular permeability was determined by Evans blue extravasation. Changes in the levels of TNF-α and IL-1β cytokines were analyzed using quantitative RT-PCR (qRT-PCR) from day 1 to day 5 post-rAION...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28291869/neuroprotective-effects-of-omega-3-polyunsaturated-fatty-acids-in-a-rat-model-of-anterior-ischemic-optic-neuropathy
#16
Tassos Georgiou, Yao-Tseng Wen, Chung-Hsing Chang, Panagiotis Kolovos, Maria Kalogerou, Ekatherine Prokopiou, Anastasia Neokleous, Chin-Te Huang, Rong-Kung Tsai
Purpose: The purpose of this study was to investigate the therapeutic effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration in a rat model of anterior ischemic optic neuropathy (rAION). Methods: The level of blood arachidonic acid/eicosapentaenoic acid (AA/EPA) was measured to determine the suggested dosage. The rAION-induced rats were administered fish oil (1 g/day EPA) or phosphate-buffered saline (PBS) by daily gavage for 10 consecutive days to evaluate the neuroprotective effects...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28281207/cilioretinal-artery-occlusion-and-anterior-ischemic-optic-neuropathy-as-the-initial-presentation-in-a-child-female-carrier-of-fabry-disease
#17
M Giray Ersoz, Gamze Ture
PURPOSE: To report the youngest female carrier of Fabry disease, complicated by cilioretinal artery occlusion and anterior ischemic optic neuropathy (AION). METHODS: Case report. RESULTS: An 11-year-old girl was referred to our clinic with painless, acute loss of vision in her right eye. Posterior segment examination and fluorescein angiography revealed cilioretinal artery occlusion and AION. Systemic evaluations were unremarkable, except for a low blood α-galactosidase A enzyme level of 242...
March 9, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28277067/platelet-activation-by-adp-is-increased-in-selected-patients-with-anterior-ischemic-optic-neuropathy-or-retinal-vein-occlusion
#18
Claudia Kuhli-Hattenbach, Peter Hellstern, Thomas Kohnen, Lars-Olof Hattenbach
To investigate whether adenosine diphosphate (ADP)-induced platelet hyperaggregability is associated with nonarteritic anterior ischemic optic neuropathy (NAION) or retinal vein occlusion (RVO). We retrospectively reviewed thrombophilia screening data of patients with NAION or RVO without a history of arterial hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette abuse. Patients with a positive family history for thromboembolism were not excluded. Platelet aggregation (area under the curve, AUC) after induction of 0...
February 16, 2017: Platelets
https://www.readbyqxmd.com/read/28258302/-ultrasound-biomicroscopy-in-giant-cell-arteritis
#19
M Pattmöller, L Daas, A Viestenz, G Milioti, A Hasenfus, B Seitz, A Viestenz
Giant cell arteritis may lead to irreversible blindness due to an anterior ischemic optic neuropathy or central retinal artery occlusion. Diagnosis of the giant cell arteritis is sometimes a problem: Difficulties may arise since a negative biopsy can not rule out the diagnosis. This case report demonstrates acute changes in the temporal artery as demonstrated by Ultrasound Biomicroscopy and documents its course during therapy with corticosteroids.
March 3, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28133888/alterations-of-the-outer-retina-in-non-arteritic-anterior-ischemic-optic-neuropathy-detected-using-spectral-domain-optical-coherence-tomography
#20
Philipp Ackermann, Maike Brachert, Philipp Albrecht, Marius Ringelstein, David Finis, Gerd Geerling, Orhan Aktas, Rainer Guthoff
BACKGROUND: Changes in peripapillary and macular retinal layer thickness in non-arteritic anterior ischemic optic neuropathy (NAION) measured using spectral-domain optical coherence tomography may reflect a characteristic disease pattern. Advanced software enables retinal layer segmentation. In this study, we compared retinal layer thicknesses in acute and chronic NAION. DESIGN: A single-center cross-sectional analysis in a university clinic. PARTICIPANTS: 14 eyes with acute (<7 days) and 13 eyes with chronic NAION and 20 age-matched healthy eyes...
January 30, 2017: Clinical & Experimental Ophthalmology
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