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Anterior Ischemic Optic Neuropathy

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https://www.readbyqxmd.com/read/28303068/high-dose-intravenous-pulse-steroid-therapy-for-optic-disc-swelling-and-subretinal-fluid-in-non-arteritic-anterior-ischemic-optic-neuropathy
#1
Kei Takayama, Hiroki Kaneko, Shu Kachi, Eimei Ra, Yasuki Ito, Hiroko Terasaki
Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease with microvascular abnormality that causes acute optic disc swelling (ODS) and, in severe cases, subretinal fluid (SRF) accumulation. ODS causes compartment syndrome and subsequent axonal degeneration and loss of retinal ganglion cells by apoptosis. No treatment modalities have been effective, although some cases improved after the intake of oral systemic steroids. We reported a case of a 72-year-old man who was referred due to a visual defect in the right eye...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28302535/aqueous-humor-cytokines-in-patients-with-acute-non-arteritic-anterior-ischemic-optic-neuropathy-naion
#2
Jonathan A Micieli, Cindy Lam, Kinda Najem, Edward A Margolin
PURPOSE: To measure and compare the cytokine concentrations in the aqueous humor of patients with acute non-arteritic anterior ischemic optic neuropathy (NAION) and normal age-related cataract controls. DESIGN: Prospective, comparative observational study. METHODS: Aqueous humor samples were obtained in 10 patients with acute NAION (within 14 days of symptom onset) and 15 control patients with age-related cataract. The levels of 6 cytokines [vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-2, IL-6, and IL-8] were determined using a multiplex bead immunoassay...
March 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28301863/optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#3
Emily Wright Mayes, Emily D Cole, Sabin Dang, Eduardo A Novais, Laurel Vuong, Carlos Mendoza-Santiesteban, Jay S Duker, Thomas R Hedges
BACKGROUND: Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016...
March 15, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28297028/early-methylprednisolone-treatment-can-stabilize-the-blood-optic-nerve-barrier-in-a-rat-model-of-anterior-ischemic-optic-neuropathy-raion
#4
Tzu-Lun Huang, Yao-Tseng Wen, Chung-Hsing Chang, Shu-Wen Chang, Kuan-Hung Lin, Rong-Kung Tsai
Purpose: We investigated whether methylprednisolone (MP) treatment halting retinal ganglion cell (RGC) death and having anti-inflammatory effect over a narrow therapeutic window affects the integrity of the blood-optic nerve barrier (BOB) in a rat model of ischemic optic neuropathy (rAION). Methods: The optic nerve (ON) vascular permeability was determined by Evans blue extravasation. Changes in the levels of TNF-α and IL-1β cytokines were analyzed using quantitative RT-PCR (qRT-PCR) from day 1 to day 5 post-rAION...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28291869/neuroprotective-effects-of-omega-3-polyunsaturated-fatty-acids-in-a-rat-model-of-anterior-ischemic-optic-neuropathy
#5
Tassos Georgiou, Yao-Tseng Wen, Chung-Hsing Chang, Panagiotis Kolovos, Maria Kalogerou, Ekatherine Prokopiou, Anastasia Neokleous, Chin-Te Huang, Rong-Kung Tsai
Purpose: The purpose of this study was to investigate the therapeutic effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration in a rat model of anterior ischemic optic neuropathy (rAION). Methods: The level of blood arachidonic acid/eicosapentaenoic acid (AA/EPA) was measured to determine the suggested dosage. The rAION-induced rats were administered fish oil (1 g/day EPA) or phosphate-buffered saline (PBS) by daily gavage for 10 consecutive days to evaluate the neuroprotective effects...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28281207/cilioretinal-artery-occlusion-and-anterior-ischemic-optic-neuropathy-as-the-initial-presentation-in-a-child-female-carrier-of-fabry-disease
#6
M Giray Ersoz, Gamze Ture
PURPOSE: To report the youngest female carrier of Fabry disease, complicated by cilioretinal artery occlusion and anterior ischemic optic neuropathy (AION). METHODS: Case report. RESULTS: An 11-year-old girl was referred to our clinic with painless, acute loss of vision in her right eye. Posterior segment examination and fluorescein angiography revealed cilioretinal artery occlusion and AION. Systemic evaluations were unremarkable, except for a low blood α-galactosidase A enzyme level of 242...
March 9, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28277067/platelet-activation-by-adp-is-increased-in-selected-patients-with-anterior-ischemic-optic-neuropathy-or-retinal-vein-occlusion
#7
Claudia Kuhli-Hattenbach, Peter Hellstern, Thomas Kohnen, Lars-Olof Hattenbach
To investigate whether adenosine diphosphate (ADP)-induced platelet hyperaggregability is associated with nonarteritic anterior ischemic optic neuropathy (NAION) or retinal vein occlusion (RVO). We retrospectively reviewed thrombophilia screening data of patients with NAION or RVO without a history of arterial hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette abuse. Patients with a positive family history for thromboembolism were not excluded. Platelet aggregation (area under the curve, AUC) after induction of 0...
February 16, 2017: Platelets
https://www.readbyqxmd.com/read/28258302/-ultrasound-biomicroscopy-in-giant-cell-arteritis
#8
M Pattmöller, L Daas, A Viestenz, G Milioti, A Hasenfus, B Seitz, A Viestenz
Giant cell arteritis may lead to irreversible blindness due to an anterior ischemic optic neuropathy or central retinal artery occlusion. Diagnosis of the giant cell arteritis is sometimes a problem: Difficulties may arise since a negative biopsy can not rule out the diagnosis. This case report demonstrates acute changes in the temporal artery as demonstrated by Ultrasound Biomicroscopy and documents its course during therapy with corticosteroids.
March 3, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28133888/alterations-of-the-outer-retina-in-non-arteritic-anterior-ischemic-optic-neuropathy-detected-using-spectral-domain-optical-coherence-tomography
#9
Philipp Ackermann, Maike Brachert, Philipp Albrecht, Marius Ringelstein, David Finis, Gerd Geerling, Orhan Aktas, Rainer Guthoff
BACKGROUND: Changes in peripapillary and macular retinal layer thickness in non-arteritic anterior ischemic optic neuropathy (NAION) measured using spectral-domain optical coherence tomography may reflect a characteristic disease pattern. Advanced software enables retinal layer segmentation. In this study, we compared retinal layer thicknesses in acute and chronic NAION. DESIGN: A single-center cross-sectional analysis in a university clinic. PARTICIPANTS: 14 eyes with acute (<7 days) and 13 eyes with chronic NAION and 20 age-matched healthy eyes...
January 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28117076/oct-angiography-of-acute-non-arteritic-anterior-ischemic-optic-neuropathy
#10
M-B Rougier, M-N Delyfer, J-F Korobelnik
PURPOSE: To describe changes of the retinal peripapillary microvasculature on optical coherence tomography angiography (OCT-A) in non-arteritic anterior ischemic optic (NAION) neuropathy. METHODS: Observational study of 10 patients at the acute phase of NAION. OCT-A was performed using a 3mm×3mm square centered on the optic disc (Cirrus HD-OCT with Angioplex, Carl Zeiss Meditec, Dublin, CA). A qualitative comparison was made with the healthy fellow eye of each patient...
February 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28108140/steroid-treatment-in-ocular-tuberculosis-a-double-edged-sword
#11
S Souissi, T David, L Beral
INTRODUCTION: We report the case of a Caribbean patient with an atypical presentation of bilateral tuberculous chorioretinopathy. PATIENT AND METHODS: A 57-year-old woman, with hypertension and non-insulin dependent diabetes, was referred to our center for a sudden loss of vision in the right eye to hand motions. Ophthalmic examination revealed only right papilledema. Brain magnetic resonance imaging was normal. Laboratory examination revealed no signs of inflammation...
February 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28108001/nonarteritic-anterior-ischemic-optic-neuropathy-and-intraocular-surgery
#12
EDITORIAL
Timothy J McCulley, Byron L Lam, William J Feuer
No abstract text is available yet for this article.
January 18, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28099197/relative-frequencies-of-arteritic-and-nonarteritic-anterior-ischemic-optic-neuropathy-in-an-arab-population
#13
Anna M Gruener, Jessica R Chang, Thomas M Bosley, Zakeya M Al-Sadah, Clarissa Kum, Timothy J McCulley
BACKGROUND: To evaluate the relative frequencies of arteritic and nonarteritic anterior ischemic optic neuropathy (AION) in an Arab population and to compare and contrast these findings with known epidemiological data from Caucasian populations. METHODS: A retrospective review of the medical records of all patients diagnosed with AION at the King Khaled Eye Specialist Hospital (KKESH) in Riyadh, Saudi Arabia, between 1997 and 2012. RESULTS: Of 171 patients with AION, 4 had biopsy-proven giant-cell arteritis (GCA)...
January 17, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28029908/pathology-of-ischemic-optic-neuropathy
#14
REVIEW
Hershel R Patel, Curtis E Margo
Ischemic optic neuropathy (ION) describes a state of hypoxic injury of the optic nerve. Clinically, ION is divided into anterior and posterior forms defined by the presence or absence of optic disc swelling, respectively. It is further classified as arteritic when secondary to vasculitis, and nonarteritic when not. The site of vascular occlusion for anterior ION from giant cell arteritis is the short posterior ciliary arteries, but mechanical vascular obstruction does not play a role in most nonarteritic cases...
January 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28017420/comparison-of-visual-outcomes-of-nonarteritic-anterior-ischemic-optic-neuropathy-in-patients-with-and-without-diabetes-mellitus
#15
Srilakshmi Sharma, Sarah Kwan, Katherine A Fallano, Jiangxia Wang, Neil R Miller, Prem S Subramanian
PURPOSE: Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN: Case-control study. PARTICIPANTS: All 231 patients with NAION seen by the Neuro-Ophthalmology Service, Wilmer Eye Institute, between 2002 and 2011 were screened for study inclusion...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27998456/-temporal-and-spatial-characteristics-of-rgc-death-and-axon-degeneration-in-the-rat-model-of-nonarteritic-anterior-ischemic-optic-neuropathy
#16
Y W Wang, T Chen, J Ma, Y Zhong
Objective: To investigate the temporal and spatial characteristics of retinal ganglion cell (RGC) death and axon degeneration in the rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). Methods: Experimental study. The model of rNAION was induced by directly illuminating the optic nerve head with laser, after intravenous infusion with the photosensitizing agent rose Bengal. Seventy-one SD rats were randomly divided into five groups: 1-week (n=14), 2-week (n=14), 4-week (n=15) , 8-week (n=16) model group and the normal control group (n=12)...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27984351/structural-and-functional-analyses-in-nonarteritic-anterior-ischemic-optic-neuropathy-optical-coherence-tomography-angiography-study
#17
Masayuki Hata, Akio Oishi, Yuki Muraoka, Kazuaki Miyamoto, Kentaro Kawai, Satoshi Yokota, Masahiro Fujimoto, Manabu Miyata, Nagahisa Yoshimura
BACKGROUND: Retinal and optic disc perfusion in nonarteritic anterior ischemic optic neuropathy (NAION) is incompletely understood. Our aim was to investigate the characteristics of the microvascular structures at the peripapillary area and optic disc, and their associations with retinal structure and function in patients with NAION. METHODS: We conducted a prospective, observational case series study. Thirty-four eyes, consisting of 15 NAION eyes and 19 normal eyes, were included...
December 14, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27984350/nonarteritic-anterior-ischemic-optic-neuropathy-and-erectile-dysfunction-drugs-is-there-an-elephant-in-the-bedroom
#18
Joshua M Kruger, Howard D Pomeranz
No abstract text is available yet for this article.
March 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27984025/post-cataract-surgery-optic-neuropathy-pcson-prevalence-incidence-temporal-relationship-and-fellow-eye-involvement
#19
Ahmadreza Moradi, Sivashakthi Kanagalingam, Marie Diener-West, Neil R Miller
PURPOSE: To reassess the prevalence and incidence of post-cataract surgery optic neuropathy (PCSON) in the modern era. DESIGN: Retrospective cohort study. SETTING: Single center, tertiary care practice. STUDY POPULATION: All patients with a diagnosis of non-arteritic anterior ischemic optic (NAION) seen in the Wilmer Eye Network system between January 1, 2010 and December 31, 2014 were included. Inclusion was based on: (1) a history of an acute unilateral decrease in vision, (2) a visual field defect consistent with NAION, (3) a relative afferent pupillary defect, (4) observed optic disc swelling, and 5) no other etiology being found...
October 27, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27982219/nonarteritic-anterior-ischemic-optic-neuropathy-following-pars-plana-vitrectomy-for-macular-hole-treatment-case-report
#20
Leonardo Provetti Cunha, Luciana Virgínia Ferreira Costa Cunha, Carolina Ferreira Costa, Mário Luiz Ribeiro Monteiro
Herein, we report a case of nonarteritic anterior ischemic optic neuropathy (NAION) following uneventful pars plana vitrectomy for macular hole treatment. A 56-year-old previously healthy woman presented with a full-thickness macular hole in right eye (OD) and small cup-to-disc ratios in both eyes. Five days after surgery, she noticed sudden painless loss of vision in OD and was found to have an afferent pupillary defect and intraocular pressure of 29 mmHg. Fundus examination showed right optic disc edema and the resolution of a macular hole with an inferior altitudinal visual field defect...
September 2016: Arquivos Brasileiros de Oftalmologia
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