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Anterior Ischemic Optic Neuropathy

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https://www.readbyqxmd.com/read/27914988/imaging-of-macrophage-dynamics-with-optical-coherence-tomography-in-anterior-ischemic-optic-neuropathy
#1
Despina Kokona, Nathanael U Häner, Andreas Ebneter, Martin S Zinkernagel
Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100'000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events occurring at the level of the optic nerve head (ONH) would be important to design future therapeutic strategies...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27914839/late-in-the-bag-intraocular-lens-dislocation-a-randomized-clinical-trial-comparing-lens-repositioning-and-lens-exchange
#2
Olav Kristianslund, Marianne Råen, Atle E Østern, Liv Drolsum
PURPOSE: To compare the efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN: Prospective, randomized, parallel-group surgical trial. PARTICIPANTS: Patients referred to Oslo University Hospital (tertiary referral center). METHODS: We randomly assigned 104 patients (104 eyes) either to IOL repositioning by scleral suturing (n = 54) or to IOL exchange with retropupillary fixation of an iris-claw IOL (n = 50)...
November 30, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27911358/the-rodent-model-of-nonarteritic-anterior-ischemic-optic-neuropathy-rnaion
#3
Yan Guo, Zara Mehrabian, Steven L Bernstein
Nonarteritic anterior ischemic optic neuropathy (NAION) is a focal ischemic lesion of the optic nerve that affects 1/700 individuals throughout their lifetime. NAION results in optic nerve edema, selective loss of the retinal ganglion cell neurons (RGCs) and atrophy of the optic nerve. A rodent model of NAION that expresses most NAION features and sequelae has been developed, which is applicable to both rats and mice. This model utilizes a focal laser application of 532 nm wavelength to illuminate a photoactive dye, Rose Bengal (RB), to cause capillary damage and leakage at the targeted anterior optic nerve (the laminar region)...
November 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27886893/erectile-dysfunction-agents-and-nonarteritic-anterior-ischemic-optic-neuropathy
#4
REVIEW
Howard D Pomeranz
Phosphodiesterase-5 inhibitors (PDE5I) are used for treatment of erectile dysfunction and pulmonary arterial hypertension and have been implicated as a causative factor for development of nonarteritic anterior ischemic optic neuropathy (NAION). Controversy remains regarding a cause and effect between PDE5I use and NAION because the mechanism by which NAION occurs is still not well understood. Because neuro-ophthalmologists have accepted that there is a potential relationship between ingestion of the PDE5I class of medications and NAION, the neuro-ophthalmologist should inquire about PDE5I use when evaluating a patient with a new diagnosis of NAION, and counsel patients regarding the implication of continued use of PDE5I...
February 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/27886887/new-treatments-for-nonarteritic-anterior-ischemic-optic-neuropathy
#5
REVIEW
Rod Foroozan
Despite increasing knowledge about the risk factors and clinical findings of nonarteritic anterior ischemic optic neuropathy (NAION), the treatment of this optic neuropathy has remained limited and without clear evidence-based benefit. Historical treatments of NAION are reviewed, beginning with the Ischemic Optic Neuropathy Decompression Trial. More recent treatments are placed within the historical context and illustrate the need for evidence-based therapy for ischemic optic neuropathy.
February 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/27871391/trying-to-understand-nonarteritic-anterior-ischemic-optic-neuropathy-through-big-data
#6
EDITORIAL
John Chen
No abstract text is available yet for this article.
December 2016: Ophthalmology
https://www.readbyqxmd.com/read/27855129/temporal-arteritis-with-arteritic-anterior-ischemic-optic-neuropathy-is-bilateral-until-proven-otherwise-response
#7
Neil R Miller, Tin Yan Alvin Liu
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27855128/giant-cell-arteritis-with-arteritic-anterior-ischemic-optic-neuropathy-is-bilateral-until-proven-otherwise
#8
Nandini Singh, Adarsh George, Jeremy Tan, Shaun Y P Ewe, Ian C Francis
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27843231/anterior-ischemic-optic-neuropathy-following-dengue-fever
#9
Reshma Ramakrishnan, Saurabh Shrivastava, Shrikant Deshpande, Priyanka Patkar
Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; and maculopathies, haemorrhage, and oedema. However anterior ischemic optic neuropathy is a rare presentation. Optic nerve ischemia most frequently occurs at the optic nerve head, where structural crowding of nerve fibers and reduction of the vascular supply may combine to impair perfusion to a critical degree and produce optic disc oedema...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27785596/the-diagnostic-accuracy-of-chromatic-pupillary-light-responses-in-diseases-of-the-outer-and-inner-retina
#10
Paul Richter, Helmut Wilhelm, Tobias Peters, Holger Luedtke, Anne Kurtenbach, Herbert Jaegle, Barbara Wilhelm
PURPOSE: To compare the chromatic pupillary light responses (PLR) in healthy subjects with those from patients with diseases of the outer or inner retina under various stimulus conditions, and to ascertain the parameters required to optimally distinguish between disease and control groups. METHODS: Fifteen patients with retinitis pigmentosa (RP), 19 patients with optic nerve disease (ON), and 16 healthy subjects were enrolled in this prospective study. ON included optic neuritis (NNO) and non-arteritic anterior ischemic optic neuropathy (NAION)...
October 26, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27761294/neutrophil-to-lymphocyte-ratio-and-non-arteritic-anterior-ischemic-optic-neuropathy
#11
Murat Afyon, Akın Çakır
No abstract text is available yet for this article.
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27689029/clinical-usefulness-of-spectral-domain-optical-coherence-tomography-in-glaucoma-and-naion
#12
REVIEW
Tae Hee Lee, Hwan Heo, Sang Woo Park
The development of optical coherence tomography (OCT) has changed the clinical management of ophthalmic diseases by furthering the understanding of pathogenesis, as well as improving the monitoring of their progression and assisting in quantifying the response to treatment modalities in ophthalmic diseases. Initially, the two-dimensional configuration of the optic nerve head (ONH) and the thickness of the retinal nerve fiber layer (RNFL) were the main OCT structural parameters used in clinical management of optic nerve diseases...
September 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/27672604/analysis-of-optic-disc-damage-by-optical-coherence-tomography-in-terms-of-therapy-in-non-arteritic-anterior-ischemic-optic-neuropathy
#13
Zsuzsa Balogh, Márta Kasza, Julianna Várdai, Izabella Reznek, Judit Damjanovich, Adrienne Csutak, András Berta, Valéria Nagy
This study aimed to assess the relationship between the rate of nerve fiber loss in non-arteritic anterior ischemic optic neuropathy (NAION) and time delay before therapy. Total 24 patients received the same treatment within or after 2wk (early and late groups). There were significantly lower level of destruction of nerve fibers (P=0.0014) and significantly better visual field sensitivity (P=0.039) in early group. The results indicate that therapy should be started within 2wk. The degree of ischemic damage due to NAION correlates well with retinal nerve fiber layer thickness and the ischemia-induced decrease in visual field sensitivity...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27661851/gaze-evoked-deformations-of-the-peripapillary-retina-in-papilledema-and-ischemic-optic-neuropathy
#14
Patrick A Sibony
Purpose: To examine the effects of horizontal eye movements on the shape of the peripapillary basement membrane layer (ppBM layer) in patients with papilledema, anterior ischemic optic neuropathy (AION) and normal eyes. Methods: Spectral-domain optical coherence tomography (SD-OCT) axial rasters of the optic nerve were used to analyze the shape of the ppBM layer. We compared registered images in two eye positions: 10° to 15° of adduction and 30° to 40° of abduction from 80 patients (45 with papilledema, 15 with AION, and 20 normal eyes)...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27659545/demographic-systemic-and-ocular-factors-associated-with-nonarteritic-anterior-ischemic-optic-neuropathy
#15
Dean M Cestari, Eric D Gaier, Peggy Bouzika, Taylor S Blachley, Lindsey B De Lott, Joseph F Rizzo, Janey L Wiggs, Jae H Kang, Louis R Pasquale, Joshua D Stein
OBJECTIVE: Nonarteritic anterior ischemic optic neuropathy (NAION) is a devastating ocular condition causing permanent vision loss. Little is known about risk factors for developing this disease. We assessed demographic, systemic, and ocular factors associated with NAION. DESIGN: Retrospective longitudinal cohort study. PARTICIPANTS: Beneficiaries between 40 and 75 years old without NAION at baseline enrolled in a large U.S. managed care network...
September 19, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27639495/-neuro-ophthalmic-emergencies
#16
A Caignard, S Leruez, D Milea
Neuro-ophthalmic emergencies can cause life-threatening or sight-threatening complications. Various conditions may have acute neuro-ophthalmic manifestations, including inflammatory or ischemic processes, as well as tumoral, aneurysmal compression or metabolic and systemic diseases. Diplopia related to a partial third nerve palsy with pupillary involvement may reveal an intracranial aneurysm. Abnormalities of conjugate gaze may reveal an inflammatory or ischemic lesion, most often of the brainstem. An intracranial tumor may also manifest itself as a single or multiple oculomotor palsy, or causing various visual field defects, due to optic nerve, chiasm or retrochiasmal involvement...
October 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27625964/bilateral-simultaneous-anterior-ischemic-optic-neuropathy-an-extrahepatic-manifestation-of-hepatitis-c-cured-with-direct-acting-antivirals
#17
Sylvie Prud'homme, Frederik Nevens, Ingele Casteels
We report a patient with a bilateral optic anterior ischemic neuropathy as an extrahepatic complication of a chronic hepatitis C (HCV) infection. The patient presented with a bilateral visual acuity loss and bilateral optic disc oedema. The optic neuropathy was associated with a sudden increase in the viral HCV load after a recent liver transplantation. The stop of the calcineurin inhibitor had no effect on the course of the optic neuropathy. Visual improvement and normalization of HCV viraemia occurred after treatment with sofosbuvir and daclatasvir, which are direct acting antivirals...
2016: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/27621919/pseudo-foster-kennedy-syndrome-as-a-rare-presentation-of-vitamin-b12-deficiency
#18
Peyman Petramfar, Farideh Hosseinzadeh, S Saeed Mohammadi
INTRODUCTION: Pseudo-Foster Kennedy syndrome is a triad consisting of ipsilateral optic atrophy, contralateral optic disc edema, and ipsilateral anosmia in the absence of an intracranial mass. Vitamin B12 plays an important role in DNA synthesis, and its deficiency causes peripheral neuropathy, myeloneuropathy, and, very rarely, optic neuropathy. CASE PRESENTATION: In this study, we describe a 34-year-old male who presented with progressive loss of visual acuity and field...
June 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27606152/letter-to-the-editor-for-neutrophil-to-lymphocyte-ratio-as-a-marker-in-patients-with-non-arteritic-anterior-ischemic-optic-neuropathy
#19
Ramazan Özelce, Fatih Çakır Gündoğan
No abstract text is available yet for this article.
July 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27603724/optic-nerve-head-morphology-in-nonarteritic-anterior-ischemic-optic-neuropathy-compared-to-open-angle-glaucoma
#20
Masoud Aghsaei Fard, Marjan Afzali, Parisa Abdi, Rebecca Chen, Mehdi Yaseri, Ebrahim Azaripour, Sasan Moghimi
PURPOSE: To compare optic nerve head (ONH) morphology of optic nerve atrophy between eyes with primary open-angle glaucoma (POAG) and eyes with a history of nonarteritic anterior ischemic optic atrophy (NAION) using enhanced depth imaging (EDI) with spectral-domain optical coherence tomography (SD-OCT). METHODS: In this cross-sectional study, 121 eyes of 91 patients consisted of moderate to severe POAG (n = 32 eyes), visual field mean deviation-matched NAION (n = 30 eyes) and their fellow eyes (n = 30 eyes), and healthy controls (n = 29)...
September 1, 2016: Investigative Ophthalmology & Visual Science
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