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prostaglandin e1

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https://www.readbyqxmd.com/read/29448512/thymosin-%C3%AE-4-reduces-h%C3%A2-o%C3%A2-induced-oxidative-stress-in-mc3t3-e1-cells-on-titanium-surface
#1
Baik-Dong Choi, Do-Seon Lim, Seung-Yeon Lee, Tae-Hee Nho, Soon-Jeong Jeong, Yeong-Mu Ko, Sung-Nam Gang, Young-Joon Kim, Xing-Hui Piao, Moon-Jin Jeong
Thymosin β4 (Tβ4) is known to inhibit an inflammatory response and to increase the survival of osteoblasts on titanium (Ti) surfaces. Ti is the most widely used graft material in dentistry; however, an inflammatory response induced following implant placement results in the generation of reactive oxygen species (ROS). The oxidative stress from the production of ROS such as nitric oxide (NO) and hydrogen peroxide (H2O2) can damage surrounding cells, resulting in implant failure by decreasing cell viability...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29417353/perioperative-management-with-phosphodiesterase-type-5-inhibitor-and-prostaglandin-e1-for-moderate-portopulmonary-hypertension-following-adult-to-adult-living-donor-liver-transplantation-a-case-report
#2
Takashi Onoe, Asuka Tanaka, Kohei Ishiyama, Kentaro Ide, Hirotaka Tashiro, Hideki Ohdan
BACKGROUND: Portopulmonary hypertension (PPH) is a relatively rare but well-recognized complication of end-stage liver disease. Moderate or severe PPH (mean pulmonary artery pressure [mPAP] ≥ 35 mmHg) is usually a contraindication for liver transplantation due to high operation-related mortality. Here, we report on a patient with moderate PPH whose condition was successfully managed with a phosphodiesterase type 5 (PDE5) inhibitor (tadalafil) and prostaglandin E1, who experienced rapid improvement of PPH after living-donor liver transplantation (LDLT)...
February 7, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29356126/acute-vascular-reaction-due-to-lipo-prostaglandin-e1
#3
Y Fujimura, M Watanabe, K Natsuga, H Shimizu
Lipo-prostaglandin E1 (Lipo-PGE1) is a PGE1 product in lipid microspheres and acts as a vasodilator. Injection of Lipo-PGE1 is used clinically for chronic skin ulcers caused by collagen diseases, diabetes mellitus and impaired blood circulation. Erythema, vascular pain, and phlebitis of the injected sites are recognized as cutaneous manifestations of the side effects of PGE1. Here we present the first case of acute vascular reaction along veins injected with Lipo-PGE1. This article is protected by copyright...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29355159/colour-doppler-sonography-of-the-penis-in-the-evaluation-of-erectile-dysfunction-our-experience-in-abuja-nigeria
#4
Joshua Oluwafemi Aiyekomogbon, Joseph Bako Igashi, Reuben Omokafe Lawan, Muftau Jimoh Bioku, Musa Ameadaji
BACKGROUND: Erectile dysfunction (ED) is an inability to achieve and maintain erectile rigidity sufficient for satisfactory sexual performance. It is either organic or psychogenic in origin. This study was aimed at establishing vasculogenic causes among patients being evaluated for ED using triplex Doppler Ultrasound. PATIENTS AND METHODS: This study was conducted at the Department of Radiology, Federal Medical Centre, Abuja, Nigeria from July 2015 to January 2017...
October 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29311680/inhibition-of-insulin-resistance-by-pge1-via-autophagy-dependent-fgf21-pathway-in-diabetic-nephropathy
#5
Wei Wei, Xing-Rong An, Shi-Jie Jin, Xiao-Xue Li, Ming Xu
Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in renal tubule epithelial cells via autophagy, which plays a protective role in DN against insulin resistance. Insulin resistance was induced by palmitic acid (PA) in human HK-2 cells, shown as the decrease of insulin-stimulated AKT phosphorylation, glucose transporter-4 (GLUT4), glucose uptake and enhanced phosphorylation of insulin receptor substrate 1(IRS-1) at site serine 307 (pIRS-1ser307) and downregulated expression of IRS-1...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29251182/comparison-of-labour-induction-with-misoprostol-and-dinoprostone-and-characterization-of-uterine-response-based-on-electrohysterogram
#6
Carlos Benalcazar-Parra, Rogelio Monfort-Orti, Yiyao Ye-Lin, Gema Prats-Boluda, Jose Alberola-Rubio, Alfredo Perales, Javier Garcia-Casado
OBJECTIVE: The objective of this study is to compare the uterine activity response between women administered dinoprostone (prostaglandin E2) and misoprostol (prostaglandin E1) for induction of labour (IOL) by analysing not only the traditional obstetric data but also the parameters extracted from uterine electrohysterogram (EHG). METHODS: Two cohorts were defined: misoprostol (25-µg vaginal tablets; 251 women) and dinoprostone cohort (10 mg vaginal inserts; 249 women)...
December 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29232862/effect-of-oxylipins-terpenoid-precursors-and-wounding-on-soft-corals-secondary-metabolism-as-analyzed-via-uplc-ms-and-chemometrics
#7
Mohamed A Farag, Hildegard Westphal, Tarek F Eissa, Ludger A Wessjohann, Achim Meyer
The effect of three oxylipin analogues, a terpenoid intermediate and wounding on the secondary metabolism of the soft corals Sarcophyton glaucum and Lobophyton pauciflorum was assessed. Examined oxylipins included prostaglandin (PG-E1), methyl jasmonate (MeJA), and arachidonic acid (AA) in addition to the diterpene precursor geranylgeranylpyrophosphate (GGP). Post-elicitation, metabolites were extracted from coral heads and analyzed via UPLC-MS followed by multivariate data analyses. Both supervised and unsupervised data analyses were used for sample classification...
December 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29206731/enteral-feeding-practices-in-infants-with-congenital-heart-disease-across-european-picus-a-european-society-of-pediatric-and-neonatal-intensive-care-survey
#8
Lyvonne N Tume, Reinis Balmaks, Eduardo da Cruz, Lynne Latten, Sascha Verbruggen, Frédéric V Valla
OBJECTIVES: To describe enteral feeding practices in pre and postoperative infants with congenital heart disease in European PICUs. DESIGN: Cross-sectional electronic survey. SETTING: European PICUs that admit infants with congenital heart disease pre- and postoperatively. PARTICIPANTS: One senior PICU physician or designated person per unit. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Fifty-nine PICUs from 18 European countries responded to the survey...
February 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29185789/integrated-treatment-of-prostaglandin-e1-and-angiotensin-converting-enzyme-inhibitor-in-diabetic-kidney-disease-rats-possible-role-of-antiapoptosis-in-renal-tubular-epithelial-cells
#9
Yaru Mou, Yaqin Zhang, Congcong Guo, Junyu Zhao, Zhongwen Zhang, Xiaojun Zhou, Jianjun Dong, Lin Liao
To investigate the therapeutic mechanisms underlying prostaglandin E1 (PGE1) and angiotensin-converting enzyme inhibitor (ACEI) on reducing urinary protein in diabetic kidney disease (DKD). DKD rats were established and randomly divided into four groups: PGE1 (10 μg/kg/day) (P group), ACEI (10 mg/kg/day) (A group), combination of PGE1 with ACEI treatment (P + A group), and saline treatment group (DKD group). Untreated rats were used as normal control (N group). Urinary albumin, endothelin-1 (ET-1), angiotensin II (AngII), TUNEL assay, Masson's trichrome staining, and immunohistochemistry staining for CD68 were evaluated in all groups...
November 29, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29173181/misoprostol-induced-acute-coronary-syndrome-in-a-premenopausal-woman-a-case-report-with-literature-review
#10
Faizan Mazhar, Jabeen Sultana, Shahzad Akram
Misoprostol is a synthetic analog of prostaglandin-E1 and it is most widely used drug for the medical management of incomplete abortion. Acute coronary syndrome (ACS) rarely occurs in perimenopausal women, in addition, the presentation is atypical, so the disease is not always recognized. We describe a case of 39-year-old woman with no major underlying cardiovascular risk factors, who developed an episode of ACS following the administration of two doses of misoprostol. After the discontinuation of misoprostol treatment, there was a complete resolution of patient's symptoms...
November 21, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/29162633/use-of-prostaglandins-in-duct-dependent-congenital-heart-conditions
#11
Yogen Singh, Paraskevi Mikrou
Congenital heart disease (CHD) remains a leading cause of infant mortality, which is even higher in infants with undiagnosed duct-dependent CHDs. Up to 39%-50% of infants with critical CHD are being discharged undiagnosed from the hospital. Infants with duct-dependent critical CHD remain well during the fetal period and may deteriorate when the ductus arteriosus (commonly called 'duct') closes after birth. It is critical to open or maintain ductus arteriosus patent in infants with duct-dependent CHDs. Prostaglandin E1 (alprostadil marketed as 'Prostin VR ') and prostaglandin E2 (dinoprostone) are used to maintain a patent ductus arteriosus and the dose of medication depends on the clinical presentation...
November 21, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29142472/prostaglandin-e1-protects-hepatocytes-against-endoplasmic-reticulum-stress-induced-apoptosis-via-protein-kinase-a-dependent-induction-of-glucose-regulated-protein-78-expression
#12
Fang-Wan Yang, Yu Fu, Ying Li, Yi-Huai He, Mao-Yuan Mu, Qi-Chuan Liu, Jun Long, Shi-De Lin
AIM: To investigate the protective effect of prostaglandin E1 (PGE1) against endoplasmic reticulum (ER) stress-induced hepatocyte apoptosis, and to explore its underlying mechanisms. METHODS: Thapsigargin (TG) was used to induce ER stress in the human hepatic cell line L02 and hepatocarcinoma-derived cell line HepG2. To evaluate the effects of PGE1 on TG-induced apoptosis, PGE1 was used an hour prior to TG treatment. Activation of unfolded protein response signaling pathways were detected by western blotting and quantitative real-time RT-PCR...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29122956/characterization-of-age-related-penile-microvascular-hemodynamic-impairment-using-laser-speckle-contrast-imaging-possible-role-of-increased-fibrogenesis
#13
Seung-Ryeol Lee, Ki-Ho Kim, Ho-Song You, Johnny Fu, Tung-Chin Mike Hsieh, Valmik Bhargava, M Raj Rajasekaran
Current technology for penile hemodynamic evaluations in small animals is invasive and has limitations. We evaluated a novel laser speckle contrast imaging (LSCI) technique to determine age-related changes in penile microvascular perfusion (PMP) and tested the role of cavernosal muscle (CC) fibrosis mediated by Wnt-TGF β1 signaling pathways in a mouse model. Ten young (2-3 months) and old (24-28 months) wild-type C57BL6 male mice were subjected to PMP measured using a LSCI system. Penile blood flow (PBF, peak systolic velocity, PSV) was also measured using a color Doppler ultrasound for comparison...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29043105/retraction-notice-to-therapeutic-effect-of-prostaglandin-e1-in-monocrotaline-induced-pulmonary-arterial-hypertension-rats-by-lee-jc-anat-cell-biol-2017-50-60-8
#14
Jae Chul Lee
[This retracts the article on p. 60 in vol. 50, PMID: 28417056.].
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29034249/misoprostol-inhibits-lipopolysaccharide-induced-pro-inflammatory-cytokine-production-by-equine-leukocytes
#15
Emily Medlin Martin, Kristen M Messenger, Mary Katherine Sheats, Samuel L Jones
Pro-inflammatory cytokines including tumor necrosis factor α (TNFα), IL-1β, IL-6, and IL-8 are potent immune mediators that exacerbate multiple equine diseases such as sepsis and laminitis. Unfortunately, safe and effective cytokine-targeting therapies are lacking in horses; therefore, novel mechanisms of inhibiting cytokine production are critically needed. One potential mechanism for inhibiting cytokine synthesis is elevation of intracellular cyclic AMP (cAMP). In human leukocytes, intracellular cAMP production is induced by activation of E-prostanoid (EP) receptors 2 and 4...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29016438/ono-1301-enhances-in-vitro-osteoblast-differentiation-and-in-vivo-bone-formation-induced-by-bone-morphogenetic-protein
#16
Sadaaki Kanayama, Takashi Kaito, Kazuma Kitaguchi, Hiroyuki Ishiguro, Kunihiko Hashimoto, Ryota Chijimatsu, Satoru Otsuru, Shota Takenaka, Takahiro Makino, Yusuke Sakai, Akira Myoui, Hideki Yoshikawa
STUDY DESIGN: In vitro and in vivo assessment of osteogenic effect by prostacyclin agonist (ONO-1301) OBJECTIVE.: To investigate the effects of ONO-1301 on in vitro osteoblastic differentiation and in vivo bone formation induced by bone morphogenetic protein (BMP). SUMMARY OF BACKGROUND DATA: Among prostaglandins (PGs), PGE2 is the most abundant in bone tissue and its effects on bone formation have been well studied. PGI2 (prostacyclin) is the second most abundant PG in bone tissue and plays important roles in hemodynamics...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28954306/prostaglandin-e1-protects-the-peripheral-nerve-in-diabetics-through-preventing-vascular-permeability-changes
#17
Feifei Mo, Guotao Hu, Wei Liu, Li He, Hailan Wang
Objective The aims of this study were to investigate the effects of the vasodilator prostaglandin E1 on microvascular permeability, the expression of vascular endothelial growth factor (VEGF), as well as the structural and functional changes of the peripheral nerve in diabetic rats. Methods Streptozotocin-induced diabetes mellitus were randomly divided into two groups and intraperitoneally received, once daily, an injection of prostaglandin E1 at 1.6 μg/kg in normal saline or the same volume of normal saline (diabetic control), respectively...
September 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28923309/altered-penile-caveolin-expression-in-diabetes-potential-role-in-erectile-dysfunction
#18
Jay Parikh, Alice Zemljic-Harpf, Johnny Fu, Dimosthenis Giamouridis, Tung-Chin Hsieh, Adam Kassan, Karnam S Murthy, Valmik Bhargava, Hemal H Patel, M Raj Rajasekaran
BACKGROUND: The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric oxide (NO) are implicated as potential mechanisms. Endothelial NO synthase, critical for NO generation, is localized to caveolae, plasma membrane lipid rafts enriched in structural proteins, and caveolins. Type 2 diabetes mellitus (T2DM)-induced changes in caveolin expression are recognized to play a role in cardiovascular dysfunction...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28919798/comparative-effects-of-the-%C3%AF-3-polyunsaturated-fatty-acid-derivatives-resolvins-e1-and-d1-and-protectin-dx-in-models-of-inflammation-and-pain
#19
Flávia Cs Fonseca, Ricardo M Orlando, Regina Mm Turchetti-Maia, Janetti Nogueira de Francischi
PURPOSE: Specialized pro-resolving lipid mediators (SPMs), also known as lipoxins, resolvins (Rvs), protectins and maresins, have been implicated in the resolution of the inflammatory process. However, a systematic comparison of their activity in the relief of inflammation and pain models is still lacking. MATERIALS AND METHODS: The effects of Rvs E1 and D1 and protectin DX (PDX) were assessed in rat paws inflamed by the standard proinflammatory stimulus carrageenan or by histamine, 5-hydroxytryptamine, substance P or prostaglandin E2...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28867757/visual-field-improvement-in-non-arteritic-posterior-ischemic-optic-neuropathy-in-a-patient-treated-with-intravenous-prostaglandin-e1-and-steroids
#20
Robert Davis Jr Steigerwalt, Paolo Giuseppe Limoli, Marcella Nebbioso
Non-arteritic posterior ischemic optic neuropathy (NA-PION) is a disorder of reduced blood flow to the retrobulbar optic nerve. There is usually an acute loss of visual acuity and field. Previous studies have noted an improvement in visual acuity and in ocular and retrobulbar blood flow with the use of a potent vasodilator of the microcirculation, prostaglandin E1 (PGE1), and steroids. The current report describes immediate improvement in the visual fields and visual acuity in a patient with NA-PION treated with intravenous PGE1 and steroids 66 hours after onset...
2017: Drug Discoveries & Therapeutics
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