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prostaglandin e1

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https://www.readbyqxmd.com/read/27892741/impact-of-prenatal-diagnosis-of-transposition-of-the-great-arteries-on-postnatal-outcome
#1
P Domínguez-Manzano, I Herraiz, A Mendoza, J M Aguilar, D Escribano, B Toral, E Gómez-Montes, A Galindo
OBJECTIVE: To assess the impact of prenatal diagnosis of transposition of the great arteries (TGA) on postnatal outcome. METHODS: 154 patients with either simple (n = 101) or complex forms (n = 53) of TGA, diagnosed prenatally (G1, n = 88) or postnatally (G2, n = 66), who were admitted and underwent surgical correction in our centre between 1998 and 2014, were analysed. RESULTS: Prostaglandin E1 (PgE1) infusion and balloon atrial septostomy (BAS) were performed in the first 48 hours after birth more commonly in G1...
November 28, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27864342/systemic-levels-of-estrogens-and-pge2-synthesis-in-relation-to-postmenopausal-breast-cancer-risk
#2
Sangmi Kim, Jeff Campbell, Wonsuk Yoo, Jack A Taylor, Dale P Sandler
BACKGROUND: Prostaglandin E2 (PGE2) induces aromatase expression in adipose tissue leading to increased estrogen production that may promote the development and progression of breast cancer. However, few studies have simultaneously investigated systemic levels of PGE2 and estrogen in relation to postmenopausal breast cancer risk. METHODS: Here we determined urinary estrogen metabolites (EMs) using mass spectrometry in a case-cohort study (295 incident breast cancer cases and 294 subcohort members), and using linear regression estimated the effect of urinary levels of a major PGE2 metabolite (PGE-M) on EMs...
November 18, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27818595/cyclooxygenase-2-expression-is-associated-with-initiation-of-hepatocellular-carcinoma-while-prostaglandin-receptor-1-expression-predicts-survival
#3
Hao-Jie Yang, Jing-Hang Jiang, Yu-Ting Yang, Xiang-Di Yang, Zhe Guo, Ya-Peng Qi, Feng-Hua Zeng, Ke-Lan Zhang, Neng-Zhi Chen, Bang-De Xiang, Le-Qun Li
AIM: To determine whether cyclooxygenase-2 (COX-2) and prostaglandin E1 receptor (EP1) contribute to disease and whether they help predict prognosis. METHODS: We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma (HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffin-embedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were determined...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27711090/penile-vascular-diagnostic-categorization-using-penile-duplex-doppler-ultrasound-differences-in-vascular-hemodynamics-parameters-by-differences-in-anatomic-sampling-location
#4
Fabio Pezzoni, Fabrizio Ildefonso Scroppo
OBJECTIVES: In 2013 the International Society for Sexual Medicine(ISSM) published the guidelines regarding the standard operating procedure (SOP) for penile duplex Doppler ultrasound (PDDU). Although ISSM-SOP have given important strides in reducing interobserver variability in PDDU by procedural protocol and parameters these guidelines do not address the anatomic location along the penis at which hemodynamic measurements have to be done. In our opinion a "double sampling" may be interesting to detect the arteriogenic or venogenic nature of the erectile dysfunction (ED)...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27707552/comparative-effectiveness-of-12-treatment-strategies-for-preventing-contrast-induced-acute-kidney-injury-a-systematic-review-and-bayesian-network-meta-analysis
#5
Xiaole Su, Xinfang Xie, Lijun Liu, Jicheng Lv, Fujian Song, Vlado Perkovic, Hong Zhang
BACKGROUND: To simultaneously evaluate the relative efficacy of multiple pharmacologic strategies for preventing contrast-induced acute kidney injury (AKI). STUDY DESIGN: Systematic review containing a Bayesian network meta-analysis of randomized controlled trials. SETTING & POPULATION: Participants undergoing diagnostic and/or interventional procedures with contrast media. SELECTION CRITERIA FOR STUDIES: Randomized controlled trials comparing the active drug treatments with each other or with hydration alone...
October 1, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27701714/the-therapeutic-effect-of-pancreatic-kininogenase-on-treatment-of-diabetic-peripheral-neuropathy-in-patients-with-type-2-diabetes
#6
Y-P Jin, X-F Su, H-Q Li, J-D Wu, B Ding, R Sun, T Shan, L Ye, J-H Ma
Background: To determine the therapeutic efficacy and cost-effective of pancreatic kininogenase (PKase) on treatment of diabetic peripheral neuropathy (DPN) compared with Prostaglandin E1 (PGE1) in patients with type 2 diabetes. Methods: 104 patients with DPN receiving standard glucose control therapy were randomly assigned into 3 groups: Group-A received PKase treatment, Group-B received PGE1 treatment, and Group-C received only standard glucose control therapy. Michigan neuropathy screening instrument (MNSI) score, neurophysiology examination, and nerve conduction velocity were measured...
November 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27676717/intracavernous-injections-in-spinal-cord-injured-men-with-erectile-dysfunction-a-systematic-review-and-meta-analysis
#7
Lucie Chochina, Florian Naudet, Isabelle Bonan, Clément Chehensse, Mireille Damphousse, Andrea Manunta, François Giuliano
OBJECTIVE: To review the efficacy of intracavernous injections (ICI) in spinal cord injured (SCI) men and to identify prognostic factors affecting the efficacy of ICI in this population. MATERIAL/PATIENTS AND METHODS: Systematic review of the literature using 5 databases. Articles published up to november 2014 using the keywords: alprostadil; papaverine; moxisylyte; alpha-blocking agent; phentolamine; intracavernous injection; spinal cord injuries; paraplegia; quadriplegia; erectile dysfunction; were included...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27673518/the-effect-of-smoking-on-necrosis-rate-in-digital-replantation-and-revascularization-with-prostaglandin-e1-therapy-a-retrospective-study
#8
Akio Nishijima, Naoto Yamamoto, Satoshi Yanagibayashi, Ryuichi Yoshida, Megumi Takikawa, Rie Kouno, Masahiko Gosho
BACKGROUND: Most microsurgeons believe that smoking and severity of injury adversely affect the outcome of digital replantation surgery. As countermeasures, several pharmacologic agents have been used for the perioperative period. The purpose of this retrospective study was to examine whether the rate of necrosis is appreciably different across smokers versus nonsmokers with prostaglandin E1 therapy. METHODS: The authors' study subjects included 144 patients (184 digits) who underwent replantation or revascularization between August of 2013 and August of 2015...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27647508/misoprostol-modulates-the-gene-expression-prostaglandin-e2-and-oxidative-stress-markers-in-myometrial-cells
#9
Cristine Kolling Konopka, Verônica Farina Azzolin, Francine Carla Cadoná, Alencar Kolinski Machado, Eduardo Bortoluzzi Dornelles, Fernanda Barbisan, Ivana Beatrice Mânica da Cruz
Misoprostol, prostaglandin E1 analogue, used for labour induction. However, one-third of patients who have labour induced with prostaglandins do not reach vaginal delivery. The differential expression of prostaglandin receptors in myometrial cells could account for this differential response. Since delivery physiology also involves modulation of oxidative metabolism that can be potentially affected by pharmacological drugs, in the present investigation the role of misoprostol on expression of prostaglandin receptors, and oxidative markers of myometrial cells was evaluated...
September 16, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27632672/human-sepsis-eicosanoid-and-proresolving-lipid-mediator-temporal-profiles-correlations-with-survival-and-clinical-outcomes
#10
Jesmond Dalli, Romain A Colas, Carolina Quintana, Diana Barragan-Bradford, Shelley Hurwitz, Bruce D Levy, Augustine M Choi, Charles N Serhan, Rebecca M Baron
OBJECTIVE: To identify and measure recently described chemical mediators, termed specialized pro-resolving mediators that actively regulate the resolution of acute-inflammation, and correlate measurements with clinical outcomes. DESIGN: Herein, deidentified plasma was collected from sepsis patients (n = 22 subjects) within 48 hours of admission to the ICU and on days 3 and 7 thereafter and subjected to lipid mediator profiling. SETTING: Brigham and Women's Hospital Medical Intensive Care Unit...
September 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27580526/clinical-outcome-of-lumbar-spinal-stenosis-based-on-new-classification-according-to-hypertrophied-ligamentum-flavum
#11
Yoshihito Sakai, Sadayuki Ito, Tetsuro Hida, Kenyu Ito, Atsushi Harada, Ken Watanabe
BACKGROUND: The ligamentum flavum hypertrophy is considered to be one of the important causes of development of lumbar spinal stenosis (LSS). Several histologic and biologic mechanisms in hypertrophied flavum have proposed. However, no study that investigated the relationship between clinical outcome and ligamentum flavum hypertrophy has been published. The purpose of this study was to identify a new classification of LSS, in ligamentous and nonligamentous stenosis, according to the cutoff value of the area proportion of the ligamentum flavum in the spinal canal, and to assess the value of surgical and conservative treatments for LSS based on the classification of the ligamentous stenosis...
August 28, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27544193/prognostic-factors-for-profound-sudden-idiopathic-sensorineural-hearing-loss-a-multicenter-retrospective-study
#12
Ho Yun Lee, Dong-Kee Kim, Yong-Ho Park, Wang Woon Cha, Geun Jeon Kim, Seung Hun Lee
The aim of this study was to assess the outcomes of various treatment modalities for profound idiopathic sudden sensorineural hearing loss (ISSNHL) and confirm the prognostic factors. In total, 191 patients were enrolled after a thorough medical chart review of patients diagnosed with unilateral, profound ISSNHL (≥90 dB). Epidemiological profiles, therapeutic regimens, and the results of pure tone audiometry tests were recorded for all patients. Final recovery was assessed according to Siegel's criteria and by comparing the final hearing level of the affected ear with that of the unaffected ear...
August 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27437309/a-comparative-study-to-evaluate-the-efficacy-of-vaginal-vs-oral-prostaglandin-e1-analogue-misoprostol-in-management-of-first-trimester-missed-abortion
#13
Sheeba Marwah, Supriya Gupta, Neera Parothi Batra, Vidhu Bhasin, Veena Sarna, Nirlep Kaur
INTRODUCTION: Missed miscarriages, occurring in upto 15% of all clinically recognized pregnancies are a cause of concern for the patients. Though many researchers in the past have compared the surgical and medical approaches in management of such patients, only a few have executed an appraisal of two routes of misoprostol at equal dosages in treatment of first trimester missed miscarriages. AIM: To compare the efficacy of misoprostol by vaginal and oral route, for the management of first trimester missed abortion; and to recognize the utility of misoprostol for cervical dilation prior to any surgical termination of pregnancy...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27421690/pge1-improves-diabetic-peripheral-neuropathy-in-patients-with-type-2-diabetes
#14
Jin-Dan Wu, Sha Tao, Xing Jin, Lan-Lan Jiang, Yun Shen, Yong Luo, Peng Zhang, Kok-Onn Lee, Lei Ye, Jian-Hua Ma
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes. We aim to investigate the efficacy of Prostaglandin E1 (PGE1) treatment in addition to intensive insulin therapy on DPN in patients with type 2 diabetes. METHODS: Seventy-seven patients with DPN received daily intravenous injection of Prostaglandin E1 (PGE1) in lipid microspheres (Lipo-PGE1) for 10days as an additional therapy to standard glucose control therapy (PGE1 group)...
July 12, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27413719/misoprostol-use-in-medical-evacuation-of-spontaneous-miscarriage-pilot-drug-use-evaluation-study-at-the-women-s-hospital-in-qatar
#15
Samah A ElSalem, Doua T AlSaad, Palli V Abdulrouf, Afif A Ahmed, Moza S AlHail
BACKGROUND: Misoprostol is a synthetic prostaglandin E1 that induces cervical effacement and uterine contractions at all gestational ages, thus facilitating uterine evacuation and pregnancy termination. Successful medical evacuation of spontaneous miscarriage with minimal adverse effects can be performed using misoprostol-only regimen if given as indicated and if the administered dose, frequency of the dosage, and number of total doses are appropriate. AIM: To conduct a drug use evaluation by investigating indications, appropriateness of dosing, and clinical outcome of misoprostol-only regimen when used for medical evacuation of spontaneous miscarriage at the Women's Hospital in Doha, Qatar...
2016: Qatar Medical Journal
https://www.readbyqxmd.com/read/27402106/erectile-dysfunction-in-systemic-sclerosis
#16
REVIEW
Veronika K Jaeger, Ulrich A Walker
Erectile dysfunction (ED) is a major issue in systemic sclerosis (SSc) as it is observed in around 80 to 90 % of men with this connective tissue disease. ED greatly impacts the quality of life and should be actively addressed as a common complication. Whereas ED in the general population is usually associated with risk factors for atherosclerosis as well as cardiovascular disease, the main aetiology of ED in SSc is microangiopathic. In SSc, the blood flow is reduced in the small penile arteries due to corporal fibrosis and myointimal proliferation...
August 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27367997/controlled-continuous-systemic-heparinization-increases-success-rate-of-artery-only-anastomosis-replantation-in-single-distal-digit-amputation-a-retrospective-cohort-study
#17
Jun Yong Lee, Hak Soo Kim, Sang Taek Heo, Ho Kwon, Sung-No Jung
Replantation is a prime indication for distal digital amputation, as it helps restore hand aesthetics and functions; however, venous anastomosis is often not feasible. Previous studies used systemic anticoagulation in distal digital artery only anastomosis replantation surgery to improve replantation success rate, however, which yielded limited level of clinical evidence. This study aimed to compare controlled continuous heparinization (CCH) and intermittent bolus heparinization (IBH) for surgical outcome and clinical variables after single distal digital artery only anastomosis replantation surgery...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27358171/new-developments-in-platelet-cyclic-nucleotide-signalling-therapeutic-implications
#18
Nathan E K Procter, Nicola L Hurst, Vivek B Nooney, Hasan Imam, Raffaele De Caterina, Yuliy Y Chirkov, John D Horowitz
Altered platelet physiology may contribute to the emergence of thrombosis in patients with many forms of cardiovascular disease. Excess platelet activation may reflect increased stimulation of pro-aggregatory pathways. There is, however, increasing evidence that excessive platelet response, due to impaired efficacy of anti-aggregatory autacoids such as nitric oxide (NO) and prostacyclin (PGI2), may be just as important. For example, diminished platelet response to NO has been documented in acute and chronic myocardial ischaemia, heart failure, aortic valve disease and in the presence of hyperglycaemia...
June 29, 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27301711/three-episodes-of-non-arteritic-posterior-ischemic-optic-neuropathy-in-the-same-patient-treated-with-intravenous-prostaglandin-e1
#19
Robert D Steigerwalt, Antonella Pascarella, Mauro De Angelis, Gabriela Grimaldi, Marcella Nebbioso
Non-arteritic posterior ischemic optic neuropathy (NA-PION) is a disorder involving reduced blood flow to the retrobulbar portion of the optic nerve. This disorder usually develops acutely, and research has suggested that high-dose steroid therapy soon after the onset of visual loss can result in significant visual improvement. This treatment, however, is not universally successful. The addition of a potent vasodilator could help to restore ocular blood flow. This case report describes the use of prostaglandin E1 (PGE1), a powerful vasodilator of the microcirculation, to treat three separate episodes of NA-PION over five years in the same patient...
2016: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/27238438/pivotal-periods-for-pregnancy-loss-during-the-first-trimester-of-gestation-in-lactating-dairy-cows
#20
REVIEW
Milo C Wiltbank, Giovanni M Baez, Alvaro Garcia-Guerra, Mateus Z Toledo, Pedro L J Monteiro, Leonardo F Melo, Julian C Ochoa, José E P Santos, Roberto Sartori
Loss of pregnancy can occur at many different stages of gestation and for a variety of causes but clearly produces a negative impact for reproductive and economic performances of dairy herds. This review describes four pivotal periods for pregnancy loss during the first trimester of gestation and discusses possible causes for pregnancy failure during these periods. The first period occurs during the first week after breeding with lack of fertilization and death of the early embryo producing major losses in pregnancy, particularly under specific environmental and hormonal conditions...
July 1, 2016: Theriogenology
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