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https://www.readbyqxmd.com/read/28930989/demonstration-of-a-hyperlens-integrated-microscope-and-super-resolution-imaging
#1
Dasol Lee, Minkyung Kim, Sunae So, Inki Kim, Gwanho Yoon, Kyunghoon Kim, Junsuk Rho
The use of super-resolution imaging to overcome the diffraction limit of conventional microscopy has attracted the interest of researchers in biology and nanotechnology. Although near-field scanning microscopy and superlenses have improved the resolution in the near-field region, far-field imaging in real-time remains a significant challenge. Recently, the hyperlens, which magnifies and converts evanescent waves into propagating waves, has emerged as a novel approach to far-field imaging. Here, we report the fabrication of a spherical hyperlens composed of alternating silver (Ag) and titanium oxide (TiO2) thin layers...
September 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930539/transcriptional-regulation-of-p57-kip2-expression-during-development-differentiation-and-disease
#2
Marianna N Rossi, Oriella Andresini, Francesca Matteini, Rossella Maione
p57(kip2) is the most complex member of the CIP/KIP family of cyclin-dependent kinase inhibitors and plays a fundamental role in regulating cell cycle and differentiation during mammalian development. Consistently with a key role for p57(kip2) in the spatial and temporal control of cell proliferation, its expression is fine-tuned by multiple regulatory mechanisms, resulting in a tissue-, developmental phase- and cell type-specific pattern. Moreover, p57(kip2) is an imprinted gene, further supporting the importance of its proper expression dosage...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930431/orientation-dependent-exciton-plasmon-coupling-in-embedded-organic-metal-nanowire-heterostructures
#3
Yong Jun Li, Yan Hong, Qian Peng, Jiannian Yao, Yong Sheng Zhao
The excitation of surface plasmons by optical emitters based on exciton-plasmon coupling is important for plasmonic devices with active optical properties. It has been theoretically demonstrated that the orientation of exciton dipole can significantly influence the coupling strength, yet systematic study of the coupling process in nanostructures is still hindered by the lack of proper material systems. In this work, we have experimentally investigated the orientation-dependent exciton-plasmon coupling in a rationally designed organic/metal nanowire heterostructure system...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28930221/compounds-from-terminalia-mantaly-l-combretaceae-stem-bark-exhibit-potent-inhibition-against-some-pathogenic-yeasts-and-enzymes-of-metabolic-significance
#4
Marthe Aimée Tchuente Tchuenmogne, Thierry Ngouana Kammalac, Sebastian Gohlke, Rufin Marie Toghueo Kouipou, Abdulselam Aslan, Muslum Kuzu, Veysel Comakli, Ramazan Demirdag, Silvère Augustin Ngouela, Etienne Tsamo, Norbert Sewald, Bruno Ndjakou Lenta, Fabrice Fekam Boyom
Background: Pathogenic yeasts resistance to current drugs emphasizes the need for new, safe, and cost-effective drugs. Also, new inhibitors are needed to control the effects of enzymes that are implicated in metabolic dysfunctions such as cancer, obesity, and epilepsy. Methods: The anti-yeast extract from Terminalia mantaly (Combretaceae) was fractionated and the structures of the isolated compounds established by means of spectroscopic analysis and comparison with literature data. Activity was assessed against Candida albicans, C...
January 24, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930100/the-joule-heating-problem-in-silver-nanowire-transparent-electrodes
#5
H H Khaligh, L Xu, A Khosropour, A Madeira, M Romano, C Pradére, M Tréguer-Delapierre, L Servant, M A Pope, I A Goldthorpe
Silver nanowire transparent electrodes have shown considerable potential to replace conventional transparent conductive materials. However, in this report we show that Joule heating is a unique and serious problem with these electrodes. When conducting current densities encountered in organic solar cells, the average surface temperature of indium tin oxide (ITO) and silver nanowire electrodes, both with sheet resistances of 60 ohms/square, remains below 35 °C. However, in contrast to ITO, the temperature in the nanowire electrode is very non-uniform, with some localized points reaching temperatures above 250 °C...
September 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28929793/stainless-steel-and-polyethylene-surfaces-functionalized-with-silver-nanoparticles
#6
José Fq Fialho, Emiliane Aa Naves, Patrícia C Bernardes, Deusmaque C Ferreira, Letícia D Dos Anjos, Rogério V Gelamo, João Pn de Sá, Nélio J de Andrade
The antimicrobial effects of a stainless steel surface and a polyethylene surface functionalized with silver nanoparticles on the adhesion of different bacteria and the changes in physical and chemical characteristics of these surfaces that influence biofilm formation were evaluated. The functionalized surfaces of polyethylene and stainless steel were more hydrophobic than the control ones. The bacterial surfaces were hydrophilic. The adhesion of all bacteria was thermodynamically favorable (ΔGadhesion<0) on all surfaces functionalized and control...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28929768/protein-corona-analysis-of-silver-nanoparticles-links-to-their-cellular-effects
#7
Sabine Juling, Alicia Niedzwiecka, Linda Böhmert, Dajana Lichtenstein, Soeren Selve, Albert Braeuning, Andreas F Thünemann, Eberhard Krause, Alfonso Lampen
The breadth of applications of nanoparticles and the access to food-associated consumer products containing nano-sized materials lead to oral human exposure to such particles. In biological fluids nanoparticles dynamically interact with biomolecules and form a protein corona. Knowledge about the protein corona is of great interest for understanding the molecular effects of particles as well as their fate inside the human body. We used a mass spectrometry-based toxicoproteomics approach to elucidate mechanisms of toxicity of silver nanoparticles and to comprehensively characterize the protein corona formed around silver nanoparticles in Caco-2 human intestinal epithelial cells...
September 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28929069/our-experience-of-treating-wide-spectrum-of-external-ear-canal-atresia-of-different-etiologies-in-pediatric-patients
#8
Kranti Bhavana
External auditory canal atresia (EACA) is a common otologic condition. Etiology can vary from congenital to acquired causes. It causes considerable difficulty to the patient. Bilateral ear canal atresia in children can lead to speech delays due to hearing impairment caused by this condition. Though easily diagnosed it is one of the most difficult conditions to treat. Acquired conditions can affect any age group. Restenosis following treatment is very common. This article focuses on the treatment of EACA due to different etiologies and emphasizes on special points of surgical treatment and follow up...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28929010/hydrology-controls-recruitment-of-two-invasive-cyprinids-bigheaded-carp-reproduction-in-a-navigable-large-river
#9
Daniel K Gibson-Reinemer, Levi E Solomon, Richard M Pendleton, John H Chick, Andrew F Casper
In the Mississippi River Basin of North America, invasive bigheaded carp (silver carp Hypophthalmichthys molitrix and bighead carp H. nobilis, also referred to as Asian carp) have spread rapidly over the past several decades. In the Illinois River, an important tributary of the Upper Mississippi River, reproduction appears to be sporadic and frequently unsuccessful, yet bigheaded carp densities in this river are among the highest recorded on the continent. Understanding the causative factors behind erratic recruitment in this commercially-harvested invasive species is important for both limiting their spread and managing their harvest...
2017: PeerJ
https://www.readbyqxmd.com/read/28928782/comparison-of-microleakage-of-scotchbond%C3%A2-universal-adhesive-with-methacrylate-resin-in-class-v-restorations-by-two-methods-swept-source-optical-coherence-tomography-and-dye-penetration
#10
Hamid Kermanshah, Hossein Khorsandian
BACKGROUND: One of the most important factors in restoration failure is microleakage at the restoration interface. Furthermore, a new generation of bonding, Scotchbond Universal (multi-mode adhesive), has been introduced to facilitate the bonding steps. The aim of this study was to compare the microleakage of Class V cavities restored using Scotchbond™ Universal with Scotchbond Multi-Purpose in two procedures. MATERIALS AND METHODS: Eighteen freshly extracted human molars were used in this study...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28928400/inhibiting-p-fluorescens-biofilms-with-fluoropolymer-embedded-silver-nanoparticles-an-in-situ-spectroscopic-study
#11
M C Sportelli, E Tütüncü, R A Picca, M Valentini, A Valentini, C Kranz, B Mizaikoff, H Barth, N Cioffi
Surface colonization by microorganisms leads to the formation of biofilms, i.e. aggregates of bacteria embedded within a matrix of extracellular polymeric substance. This promotes adhesion to the surface and protects bacterial community, providing an antimicrobial-resistant environment. The inhibition of biofilm growth is a crucial issue for preventing bacterial infections. Inorganic nanoparticle/Teflon-like (CFx) composites deposited via ion beam sputtering demonstrated very efficient antimicrobial activity...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928129/new-advances-and-challenges-of-targeting-cancer-stem-cells
#12
Nurmaa K Dashzeveg, Rokana Taftaf, Erika K Ramos, Luke Torre-Healy, Anastasia Chumakova, Daniel J Silver, Tyler J Alban, Maksim Sinyuk, Praveena S Thiagarajan, Awad M Jarrar, Soumya M Turaga, Caner Saygin, Erin Mulkearns-Hubert, Masahiro Hitomi, Jeremy N Rich, Stanton L Gerson, Justin D Lathia, Huiping Liu
The second International Cancer Stem Cell Conference in Cleveland, Ohio, on September 20-23, 2016, convened 330 attendees from academic, industrial, and clinical organizations. It featured a debate on the concepts and challenges of the cancer stem cells (CSC) as well as CSC-centered scientific sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression, metastasis, therapeutic resistance, and emerging novel concepts. The conference hosted 35 renowned speakers, 100 posters, 20 short talks, and a preconference workshop...
September 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/28926707/medieval-gilding-technology-of-historical-metal-threads-revealed-by-electron-optical-and-micro-raman-spectroscopic-study-of-focused-ion-beam-milled-cross-sections
#13
Tamás Gábor Weiszburg, Katalin Gherdán, Kitti Ratter, Norbert Zajzon, Zsolt Bendő, György Z Radnoczi, Ágnes Takács, Tamás Váczi, Gábor Varga, György Szakmány
Although gilt silver threads were widely used for decorating historical textiles, their manufacturing techniques have been elusive for centuries. Contemporary written sources give only limited, sometimes ambiguous information, and detailed cross-sectional study of the microscale soft noble metal objects has been hindered by sample preparation. In this work, to give a thorough characterization of historical gilt silver threads, nano- and microscale textural, chemical and structural data on cross sections, prepared by focused ion beam milling, were collected, using various electron-optical methods (high-resolution scanning electron microscopy (SEM), wavelength-dispersive electron probe microanalysis (EPMA), electron back-scattered diffraction (EBSD) combined with energy-dispersive electron probe microanalysis (EDX), transmission electron microscopy (TEM) combined with EDX, and micro-Raman spectroscopy...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926701/forensic-sampling-and-analysis-from-a-single-substrate-for-surface-enhanced-raman-spectroscopy-followed-by-paper-spray-mass-spectrometry
#14
Patrick W Fedick, Brandon J Bills, Nicholas E Manicke, R Graham Cooks
Sample preparation is the most common bottle-neck in the analysis and processing of forensic evidence. Time-consuming steps in many forensic tests involve complex separations such as liquid and gas chromatography or various types of extraction techniques, typically coupled with mass spectrometry (e.g. LC-MS). Ambient ionization ameliorates these slow steps by reducing or even eliminating sample preparation. While some ambient ionization techniques have been adopted by the forensic community, there is significant resistance to discarding chromatography as most forensic analyses require both an identification and a confirmation technique...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926628/application-of-raman-spectroscopy-in-type-2-diabetes-screening-in-blood-using-leucine-and-isoleucine-amino-acids-as-biomarkers-and-in-comparative-anti-diabetic-drugs-efficacy-studies
#15
Zephania Birech, Peter Waweru Mwangi, Fredrick Bukachi, Keith Makori Mandela
Diabetes is an irreversible condition characterized by elevated blood glucose levels. Currently, there are no predictive biomarkers for this disease and the existing ones such as hemoglobin A1c and fasting blood glucose are used only when diabetes symptoms are noticed. The objective of this work was first to explore the potential of leucine and isoleucine amino acids as diabetes type 2 biomarkers using their Raman spectroscopic signatures. Secondly, we wanted to explore whether Raman spectroscopy can be applied in comparative efficacy studies between commercially available anti-diabetic drug pioglitazone and the locally used anti-diabetic herbal extract Momordica spinosa (Gilg...
2017: PloS One
https://www.readbyqxmd.com/read/28926224/silver-nanocluster-embedded-zein-films-as-antimicrobial-coating-materials-for-food-packaging
#16
Lei Mei, Zi Teng, Guizhi Zhu, Yijing Liu, Fuwu Zhang, Jinglin Zhang, Ying Li, Yongguang Guan, Yaguang Luo, Xianggui Chen, Qin Wang
Highly efficient antimicrobial agents with low toxicity and resistance have been enthusiastically pursued to address public concerns on microbial contamination in food. Silver nanoclusters (AgNCs) are known for their ultra-small sizes and unique optical and chemical properties. Despite extensive studies of AgNCs for biomedical applications, previous research on their application as antimicrobials for food applications is very limited. Here, for the first time, by incorporating AgNCs (~ 2 nm in diameter) into zein films that are widely used as food packaging materials, we developed a novel coating material with potent antimicrobial activity, low toxicity to human cells, and low potential to harm the environment...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28926064/quantitative-sers-by-hot-spot-normalization-surface-enhanced-rayleigh-band-intensity-as-an-alternative-evaluation-parameter-for-sers-substrate-performance
#17
Haoran Wei, Alexis McCarthy, Junyeob Song, Wei Zhou, Peter J Vikesland
The performance of surface-enhanced Raman spectroscopy (SERS) substrates is typically evaluated by calculating an enhancement factor (EF). However, it is challenging to accurately calculate EF values since the calculation often requires the use of model analytes and requires assumptions about the number of analyte molecules within the laser excitation volume. Furthermore, the measured EF values are target analyte dependent and thus it is challenging to compare substrates with EF values obtained using different analytes...
September 19, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28925873/silver-nanoparticles-with-high-loading-capacity-of-amphotericin-b-characterization-bactericidal-and-antifungal-effects
#18
Victoria Leonhard, Roxana Valeria Alasino, Adrián Muñoz, Dante Miguel Beltramo
The purpose of this study was to evaluate the most appropriate conditions to generate silver nanoparticles (AgNPs) loaded with a potent antimycotic drug like amphotericin B (AmB), characterize the physicochemical properties, and also evaluate the cytotoxic effect and biological activity of these new nanostructures as a potential nanocarrier for hydrophobic drugs. It was determined that the optimal molar ratio between Ag and AmB is 1/1 given the uniformity of size around 1750 nm of the nanoparticles generated as well as their strongly negative ζ potential of -27 mV, a condition that favors repulsions between AgNPs and inhibiting their aggregation...
September 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28923716/investigation-of-the-effect-of-pomegranate-extract-and-monodisperse-silver-nanoparticle-combination-on-mcf-7-cell-line
#19
Birgütay Şahin, Enes Demir, Ayşenur Aygün, Hülya Gündüz, Fatih Şen
In this study, we aimed to investigate whether the combination therapy of pomegranate extract and silver nanoparticle is effective on MCF-7 cell culture. The pomegranate extract was mixed and incubated with silver nitrate for the microwave assisted green synthesized of silver nanoparticle. Obtained nanoparticles were investigated using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), UV-visible, Field Emission Scanning Electron Microscopy (FESEM), and Transmission Electron Microscopy (TEM) methods The spectroscopic and morphological studies of the monodisperse Ag NPs which have particle size of 15...
September 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28923599/-theranostic-role-of-bile-salt-capped-silver-nanoparticles-gall-stone-pigment-stone-disruption-and-anticancer-activity
#20
Ranju Prasad Mandal, Gunjan Mandal, Sudeshna Sarkar, Arindam Bhattacharyya, Swati De
Silver nanoparticles (AgNPs) have been synthesized in situ in micelles formed by the bile salt sodium deoxycholate (NaDC). The AgNPs exhibit "green" fluorescence. It has been shown in the present study that they can disrupt the components of gall stones/pigment stones. This unique ability of the AgNPs has been observed upon detailed study of the interaction between the endobiotic pigment bilirubin (BR) and bile salt (NaDC). In addition, these AgNPs show significant cytotoxicity towards the breast cancer cells (MCF-7)...
September 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
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