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Ruth E K Stein, Ellen J Silver, Marilyn C Augustyn, Nathan J Blum, Pamela High, Nancy J Roizen
BACKGROUND: It is unknown how insurance status affects elements of evaluation at developmental behavioral (DB) pediatric sites. OBJECTIVE: To compare DB referrals, evaluation, and treatment for children with Medicaid and private insurance. DESIGN/METHODS: Fifty-six developmental behavioral pediatricians at 12 sites recorded anonymous data on structured forms for ≤15 consecutive referrals. Children with Medicaid (n = 309) and private insurance (n = 393) were compared on sociodemographic factors, referral concerns, evaluation elements, and resulting diagnoses...
March 19, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Grace Chai, Jing Xu, James Osterhout, Mark A Liberatore, Kathleen L Miller, Carolyn Wolff, Marisa Cruz, Peter Lurie, Gerald Dal Pan
BACKGROUND: The opioid epidemic, driven in part by increased prescribing, is a public health emergency. This study examines dispensed prescription patterns and approvals of new opioid analgesic products to investigate whether the introduction of these new drugs increases prescribing. METHODS: Prescribing patterns based on dispensed prescription claims from the U.S. retail setting were assessed with new brand and generic opioid analgesic products approved in the United States from 1997 through 2015...
March 20, 2018: Anesthesiology
Massimo Zimbone, Annalinda Contino, Giuseppe Maccarrone, Paolo Musumeci, Maria Josè Josè Lo Faro, Lucia Calcagno
The stability of silver nanoplatelet suspensions prepared with different concentrations of Trisodium Citrate (TSC) was studied by depolarized dynamic light scattering and UV-vis spectrometry. The morphology of the nanoparticles, as well as the color and stability of the sols, are tuned by the concentration of the capping agent. The nanoparticles prepared with high TSC concentration (> 10-4 M) are blue triangular nanoplatelets showing a slight truncation of the tips with aging. When low TSC concentrations are used, the color of the sols changes from blue to yellow with aging time and a strong modification of the morphology occurs: the nanoparticle shape changes from triangular to spherical...
March 20, 2018: Nanotechnology
Ying-Hua Zhao, Shi-Jian Zhang, Zi-Hui Yang, Xiao-Chang Liu, De-Lin Lei, Jing Li, Lei Wang
Distraction osteogenesis is an important technique for the treatment of maxillofacial abnormities and defects. However, distraction osteogenesis may cause the injury of the inferior alveolar nerve. The relationship between distraction rate and nerve degeneration-regeneration shift remains poorly understood. In this study, 24 rabbits were randomly divided into four groups. To establish the rabbit mandibular distraction osteogenesis model, the mandibles of rabbits in distraction osteogenesis groups were subjected to continuous osteogenesis distraction at a rate of 1...
February 2018: Neural Regeneration Research
Mert Vural, Adam Michael Behrens, Wonseok Hwang, Joseph J Ayoub, Dalton Chasser, Arthur von Wald Cresce, Robert M Briber, Peter Kofinas
Highly conductive elastic composites were constructed using multi-step solution based fabrication methods that included the deposition of a non-woven polymer fiber mat through solution blow spinning and nanoparticle nucleation. High nanoparticle loading was achieved by introducing silver nanoparticles into the fiber spinning solution. The presence of the silver nanoparticles facilitates improved uptake of silver nanoparticle precursor in subsequent processing steps. The precursor is used to generate a second nanoparticle population, leading to high loading and conductivity...
March 20, 2018: ACS Applied Materials & Interfaces
Li-Chuan Jia, Ding-Xiang Yan, Xiaofeng Liu, Rujun Ma, Hong-Yuan Wu, Zhongming Li
Electromagnetic protection in optoelectronic instruments such as optical windows and electronic displays is challenging because of the essential requirements of a high optical transmittance and an electromagnetic interference (EMI) shielding effectiveness (SE). Herein, we demonstrate the creation of an efficient transparent EMI shielding film that is composed of calcium alginate (CA), silver nanowires (AgNWs), and polyurethane (PU), via a facile and low-cost Meyer-rod coating method. The CA/AgNWs/PU film with a high optical transmittance of 92% achieves an EMI SE of 20...
March 20, 2018: ACS Applied Materials & Interfaces
M Di Giulio, V Di Valerio, D Bosco, E Marsich, A Cataldi, L Cellini, S Sancilio
The molecular mechanisms leading to Streptococcus mitis capability of entering oral cells were investigated in a co-culture of S. mitis and Human Gingival Fibroblasts (HGFs) in the presence of saliva. An innovative colloidal solution based on silver nanoparticles (Chitlac-nAg), a promising device for daily oral care, was added to the experimental system in order to study the effects of silver on the bacterial overgrowth and ability to enter non-phagocytic eukaryotic cells. The entry of bacteria into the eukaryotic cells is mediated by a signalling pathway involving FAK, integrin β1, and the two cytoskeleton proteins vinculin and F-actin, and down-regulated by the presence of saliva both at 3 and 48 h of culture, whereas Chitlac-n Ag exposure seems to influence, by incrementing it, the number of bacteria entering the fibroblasts only at 48 h...
March 19, 2018: Journal of Materials Science. Materials in Medicine
Holly J Silvers-Granelli, Mario Bizzini, Amelia Arundale, Bert R Mandelbaum, Lynn Snyder-Mackler
PURPOSE: The 11+ injury prevention program has been shown to decrease injury rate. However, few studies have investigated compliance and if it is correlated to time loss. The purpose of this study was to (1) analyze how differences in compliance may impact injury rate and (2) if compliance may impact time loss due to injury. METHODS: This study was a Level 1 prospective cluster randomized controlled trial conducted in NCAA men's football (soccer) teams that examined the efficacy of the 11+ injury prevention program...
March 19, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Zahra Heidari, Ali Salehzadeh, Seyed Ataollah Sadat Shandiz, Sara Tajdoost
This study highlights the anti-oxidant and anti-cancer activities of bio-functionalized Thymus vulgaris silver nanoparticles (TVAgNPs) and bioactive compounds were compared using the human breast cancer T47D cell line. The aqueous ethanolic extract of T. vulgaris evaluated for chemical composition using the gas chromatography-mass spectrometer (GC-MS) analysis. The prepared TVAgNPs were determined by means of UV-Vis spectroscopy, FTIR spectroscopy, zeta potential, scanning electron microscopy, transmission electron microscopy, and energy-dispersed spectroscopy analysis...
March 2018: 3 Biotech
Jinshan Guo, Wei Sun, Jimin Peter Kim, Xili Lu, Qiyao Li, Min Lin, Oliver Mrowczynski, Elias B Rizk, Juange Cheng, Guoying Qian, Jian Yang
Tissue adhesives play an important role in surgery to close wounds, seal tissues, and stop bleeding, but existing adhesives are costly, cytotoxic, or bond weakly to tissue. Inspired by the water-resistant adhesion of plant-derived tannins, we herein report a new family of bioadhesives derived from a facile, one-step Michael addition of tannic acid and gelatin under oxidizing conditions and crosslinked by silver nitrate. The oxidized polyphenol groups of tannic acid enable wet tissue adhesion through catecholamine-like chemistry, while both tannic acid and silver nanoparticles reduced from silver nitrate provide antimicrobial sources inherent within the polymeric network...
March 16, 2018: Acta Biomaterialia
R A González-Fuenzalida, L Sanjuan-Navarro, Y Moliner-Martínez, P Campíns-Falcó
The capacity of different soils to capture silver nanoparticles (AgNPs) by measuring changes of an AgNP intrinsic property such as the plasmon for the first time, was studied. In-tube solid-phase microextraction (IT-SPME) coupled on-line to capillary liquid chromatography (CapLC) with diode array detection (DAD) was employed for measuring the interactions between soil and in-contact AgNP dispersions. Its achieved LOD 9 pM assures quantitative retention measurements and selectivity for soil lixiviation was suitable...
March 2, 2018: Science of the Total Environment
Małgorzata Jakubowicz, Witold Nowak, Łukasz Gałgański, Danuta Babula-Skowrońska
In this report, the members of PP2C, SnRK2a and Rboh oxidase families from Arabidopsis and poplar were studied in silico, and the expression profiles of the some of them were specified in Populus tremula buds and adult leaves. In poplars, the counterparts of ABI1- and ABI2-like protein phosphatases are lacking, but poplar genomes encode three HAB-like proteins denoted in this work as HAB1, HAB3a and HAB3b, and the counterparts of the two latter ones are absent in Arabidopsis. Nonetheless, they may be present in other species...
March 7, 2018: Journal of Plant Physiology
Md Saiful Islam, M Belal Hossain, Abdul Matin, Md Shafiqul Islam Sarker
Heavy metal pollution in sediment resources may pose serious threat to ecosystem and human health through food web. In this study, surface sediment samples of 10 stations along the Feni River estuary were analyzed to profile the accumulation, sources and pollution levels of heavy metals. The results revealed that the average contents (μg g-1 ) of eight selected heavy metals followed the order of Mn (37.85) > Cr (35.28) > Ni (33.27) > Co (31.02) > Pb (6.47) > Ag (1.09) > As (0...
March 13, 2018: Chemosphere
Barbara Różalska, Beata Sadowska, Aleksandra Budzyńska, Przemysław Bernat, Sylwia Różalska
Due to low efficacy of classic antimicrobial drugs, finding new active preparations attracts much attention. In this study an innovative, cost-effective and environmentally friendly method was applied to produce silver nanoparticles (AgNPs) using filamentous fungi Metarhizium robertsii biomass waste. It was shown that these NPs possess prominent antifungal effects against C. albicans, C. glabrata and C. parapsilosis reference strains. Further detailed studies were performed on C. albicans ATCC 90028. AgNPs kill curve (CFU method and esterase-mediated reduction of fluorescein diacetate); fractionally inhibitory concentration index (FICI) with fluconazole (FLC); effect on fungal cell membrane permeability (propidium iodide (PI) staining), membrane lipids profile (HPLC-MS), yeast morphotypes and intracellular reactive oxygen species level (H2DCFDA probe) were investigated...
2018: PloS One
Imelda Galván Márquez, Mergan Ghiyasvand, Andrey Massarsky, Mohan Babu, Bahram Samanfar, Katayoun Omidi, Thomas W Moon, Myron L Smith, Ashkan Golshani
Engineered nanomaterials (ENMs) are increasingly incorporated into a variety of commercial applications and consumer products; however, ENMs may possess cytotoxic properties due to their small size. This study assessed the effects of two commonly used ENMs, zinc oxide nanoparticles (ZnONPs) and silver nanoparticles (AgNPs), in the model eukaryote Saccharomyces cerevisiae. A collection of ≈4600 S. cerevisiae deletion mutant strains was used to deduce the genes, whose absence makes S. cerevisiae more prone to the cytotoxic effects of ZnONPs or AgNPs...
2018: PloS One
Mithun Sikder, Emily Eudy, G Thomas Chandler, Mohammed Baalousha
Many nanotoxicological studies have assessed the acute toxicity of nanoparticles (NPs) at high exposure concentrations. There is a gap in understanding NP chronic environmental effects at lower exposure concentrations. This study reports life-cycle chronic toxicity of sublethal exposures of polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs) relative to dissolved silver nitrate (AgNO3 ) for the estuarine meiobenthic copepod, Amphiascus tenuiremis, over a range of environmentally relevant concentrations, i...
March 19, 2018: Nanotoxicology
Meng-Ting Li, Xi-Ya Yang, Ji-Sen Li, Ning Sheng, Guo-Dong Liu, Jing-Quan Sha, Ya-Qian Lan
For exploring the multifold helical fabrication of polyoxometalate (POM)-based hybrid compounds, four POM-based crystalline compounds with different meso-helices, H3 [Ag27 (trz)16 (H2 O)6 ][SiW12 O40 ]2 ·5H2 O (1), H[Ag27 (trz)16 (H2 O)4 ][PW12 O40 ]2 ·2H2 O (2), [Ag23 (trz)14 (H2 O)2 ][HSiW12 O40 ] (3), and [Ag23 (trz)14 (H2 O)2 ][PW12 O40 ] (4), were successfully isolated by using the delicate 1,2,3-triazole ligand and silver ions in this work. Crystal analysis reveals that compounds 1 and 2 and compounds 3 and 4 are isomorphous and display 2-/4-fold mixed meso-helices and simple 2-fold meso-helices, respectively...
March 19, 2018: Inorganic Chemistry
Bhavana V Mohite, Sunil H Koli, Satish V Patil
Currently, the heavy metal pollution is of grave concern, and the part of microorganism for metal bioremediation should take into account as an efficient and economic strategy. On this framework, the heavy metal stress consequences on exopolysaccharide (EPS)-producing agricultural isolate, Pantoea agglomerans, were studied. The EPS production is a protective response to stress to survive and grow in the metal-contaminated environment. P. agglomerans show tolerance and mucoid growth in the presence of heavy metals, i...
March 19, 2018: Applied Biochemistry and Biotechnology
Hussaina Banu, N Renuka, S M Faheem, Raees Ismail, Vinita Singh, Zahra Saadatmand, Saad Sultan Khan, Kavya Narayanan, Alma Raheem, Kumpati Premkumar, Geetha Vasanthakumar
Recently, several attempts have been made to use the phytopharmaceuticals from plant extracts as reducing, capping and stabilizing agents for the biomimetic synthesis of various metal nanoparticles conjugated to the phytopharmaceuticals. These biogenic metal nanoparticles are non-toxic and can be used as contrast agents, drug delivery vehicles and photothermal agents for cancer therapy. Herein, we report the synthesis of both silver and gold nanoparticles using the pollen extract of Phoenix dactylifera (Date Palm), characterization using UV-visible spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy, quantitation of phytochemicals capping the nanoparticles using Folin - Ciocalteu's method, cytotoxicity studies on MCF-7 breast cancer cells, cancer cell death analysis using fluorescent microscopy, and modulation of expression of the pro-apoptotic p53 and anti-apoptotic Bcl-2 proteins...
March 18, 2018: Biological Trace Element Research
Happy Agarwal, Soumya Menon, S Venkat Kumar, S Rajeshkumar
A large array of diseases caused by bacterial pathogens and origination of multidrug resistance in their gene provokes the need of developing new vectors or novel drug molecules for effective drug delivery and thus, better treatment of disease. The nanoparticle has emerged as a novel drug molecule in last decade and has been used in various industrial fields like cosmetics, healthcare, agricultural, pharmaceuticals due to their high optical, electronic, medicinal properties. Use of nanoparticles as an antibacterial agent remain in current studies with metal nanoparticles like silver, gold, copper, iron and metal oxide nanoparticles like zinc oxide, copper oxide, titanium oxide and iron oxide nanoparticles...
March 15, 2018: Chemico-biological Interactions
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