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https://www.readbyqxmd.com/read/29028824/the-association-between-serum-brain-derived-neurotrophic-factor-and-a-cluster-of-cardiovascular-risk-factors-in-adolescents-the-champs-study-dk
#1
Natascha Holbæk Pedersen, Jakob Tarp, Lars Bo Andersen, Anne Kær Gejl, Tao Huang, Lone Peijs, Anna Bugge
BACKGROUND AND OBJECTIVE: Cardiovascular disease and type 2 diabetes pose a global health burden. Therefore, clarifying the pathology of these risk factors is essential. Previous studies have found positive and negative associations between one or more cardiovascular risk factors and brain-derived neurotrophic factor (BDNF) probably due to diverse methodological approaches when analysing peripheral BDNF levels. Moreover, only a few studies have been performed in youth populations. Consequently, the main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/29027533/factors-associated-with-circulating-concentrations-of-irisin-in-the-general-population-cohort-of-the-abcd-study
#2
S Buscemi, D Corleo, S Vasto, C Buscemi, M F Massenti, D Nuzzo, G Lucisano, A M Barile, G Rosafio, V Maniaci, C Giordano
BACKGROUND: Animal studies have shown that irisin is a myokine secreted following physical exercise, and that it induces the remodeling of white adipose tissue toward brown adipose tissue. Therefore, a protective role of irisin against obesity, diabetes, and other metabolic and cardiovascular conditions has been hypothesized. However, data in humans are contradictory and few data are available concerning the general population. AIMS: We aimed to evaluate the association between serum irisin concentrations and habitual physical activity, as well as other metabolic and cardiovascular factors in a general population in a Mediterranean area...
October 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29027131/selective-bet-protein-inhibition-with-apabetalone-and-cardiovascular-events-a-pooled-analysis-of-trials-in-patients-with-coronary-artery-disease
#3
Stephen J Nicholls, Kausik K Ray, Jan O Johansson, Alan Gordon, Michael Sweeney, Chris Halliday, Ewelina Kulikowski, Norman Wong, Susan W Kim, Gregory G Schwartz
BACKGROUND: Inhibition of bromodomain and extra-terminal (BET) proteins can modulate lipoprotein and inflammatory factors that mediate atherosclerosis. The impact of the BET inhibitor, apabetalone, on cardiovascular events is unknown. OBJECTIVE: Our objective was to investigate the impact of apabetalone on cardiovascular event rates in a pooled analysis of clinical studies in patients with established coronary artery disease. METHODS: We conducted a pooled analysis of patients (n = 798) with coronary artery disease who participated in clinical trials (ASSERT, ASSURE, SUSTAIN) that evaluated the impact of 3-6 months of treatment with apabetalone on lipid parameters and coronary atherosclerosis...
October 12, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29026804/the-effect-of-cardamom-supplementation-on-serum-lipids-glycemic-indices-and-blood-pressure-in-overweight-and-obese-pre-diabetic-women-a-randomized-controlled-trial
#4
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29025709/reduction-of-in-stent-restenosis-by-cholesteryl-ester-transfer-protein-inhibition
#5
Ben J Wu, Yue Li, Kwok L Ong, Yidan Sun, Sudichhya Shrestha, Liming Hou, Douglas Johns, Philip J Barter, Kerry-Anne Rye
OBJECTIVE: Angioplasty and stent implantation, the most common treatment for atherosclerotic lesions, have a significant failure rate because of restenosis. This study asks whether increasing plasma high-density lipoprotein (HDL) levels by inhibiting cholesteryl ester transfer protein activity with the anacetrapib analog, des-fluoro-anacetrapib, prevents stent-induced neointimal hyperplasia. APPROACH AND RESULTS: New Zealand White rabbits received normal chow or chow supplemented with 0...
October 12, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29025430/genetic-architecture-of-lipid-traits-in-the-hispanic-community-health-study-study-of-latinos
#6
Mariaelisa Graff, Leslie S Emery, Anne E Justice, Esteban Parra, Jennifer E Below, Nicholette D Palmer, Chuan Gao, Qing Duan, Adan Valladares-Salgado, Miguel Cruz, Alanna C Morrison, Eric Boerwinkle, Eric A Whitsel, Charles Kooperberg, Alex Reiner, Yun Li, Carlos Jose Rodriguez, Gregory A Talavera, Carl D Langefeld, Lynne E Wagenknecht, Jill M Norris, Kent D Taylor, George Papanicolaou, Eimear Kenny, Ruth J F Loos, Yii-Der Ida Chen, Cathy Laurie, Tamar Sofer, Kari E North
BACKGROUND: Despite ethnic disparities in lipid profiles, there are few genome-wide association studies investigating genetic variation of lipids in non-European ancestry populations. In this study, we present findings from genetic association analyses for total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides in a large Hispanic/Latino cohort in the U.S., the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)...
October 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29025405/the-anti-inflammatory-function-of-hdl-is-impaired-in-type-2-diabetes-role-of-hyperglycemia-paraoxonase-1-and-low-grade-inflammation
#7
Sanam Ebtehaj, Eke G Gruppen, Mojtaba Parvizi, Uwe J F Tietge, Robin P F Dullaart
BACKGROUND: Functional properties of high density lipoproteins (HDL) are increasingly recognized to play a physiological role in atheroprotection. Type 2 diabetes mellitus (T2DM) is characterized by low HDL cholesterol, but the effect of chronic hyperglycemia on the anti-inflammatory capacity of HDL, a metric of HDL function, is unclear. Therefore, the aim of the present study was to establish the impact of T2DM on the HDL anti-inflammatory capacity, taking paraoxonase-1 (PON-1) activity and low grade inflammation into account...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29025356/associations-between-sleep-deprivation-and-salivary-testosterone-levels-in-male-university-students-a-prospective-cohort-study
#8
Mahmoud Suleiman Abu-Samak, Beisan Ali Mohammad, May Ibrahim Abu-Taha, Luai Zidan Hasoun, Shady Helmi Awwad
Sleep deprivation is a common health problem that is growing rapidly worldwide and it is associated with short- and long-term impacts on health. The aim of this study was to detect potential predictors of salivary testosterone (sT) association with sleep deprivation in Arab male university students. In this prospective cohort study, 77 university male students in the age range of 18 to 26 years were divided into two groups, sleep-deprived (SD) participants and non-sleep-deprived (NSD) participants. Sleep deprivation was defined as sleeping less than 5 hr per night...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29025201/the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-overweight-korean-children-and-adolescents
#9
Dong-Yoon Yoo, Yu Sun Kang, Eun Byul Kwon, Eun-Gyong Yoo
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025108/hdl-cholesterol-levels-and-risk-of-age-related-macular-degeneration-a-multiethnic-genetic-study-using-mendelian-randomization
#10
Qiao Fan, Joseph C Maranville, Lars Fritsche, Xueling Sim, Chui Ming Gemmy Cheung, Li Jia Chen, Mathias Gorski, Kenji Yamashiro, Jeeyun Ahn, Augustinus Laude, Rajkumar Dorajoo, Tock Han Lim, Yik-Ying Teo, Robert O Blaustein, Nagahisa Yoshimura, Kyu-Hyung Park, Chi Pui Pang, E Shyong Tai, Chiea Chuen Khor, Tien Yin Wong, Heiko Runz, Ching-Yu Cheng
Background: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. Methods: We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 832 controls of European descent, together with 2219 cases and 5275 controls of Asian descent, using Mendelian randomization in three models...
September 12, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29023344/biometric-screening-and-future-employer-medical-costs-is-it-worth-it-to-know
#11
Greg Vanichkachorn, Maya Marchese, Brad Roy, Gordon Opel
OBJECTIVE: To study the relationship between a biometric wellness data and future/actual medical costs. METHODS: A relationship between TC/HDL ratio, blood pressure, and blood glucose and medical costs, based on analysis of claims data, was explored in 1834 employees that had both wellness program biometric and claims data in 2016. RESULT: Increased total cholesterol to HDL ratio is strongly associated with increased average costs (p < 0...
October 11, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29022212/effect-of-food-on-the-pharmacokinetics-of-saroglitazar-magnesium-a-novel-dual-ppar%C3%AE-%C3%AE-agonist-in-healthy-adult-subjects
#12
Maulik R Patel, Kevinkumar A Kansagra, Devang P Parikh, Deven V Parmar, Hardik B Patel, Mayur M Soni, Uday S Patil, Harilal V Patel, Jaimik A Patel, Swagat S Gujarathi, Krupi V Parmar, Nuggehally R Srinivas
BACKGROUND AND OBJECTIVE: Peroxisome proliferator-activated receptors (PPARs) have recently become a focus of interest for their important roles in glucose and lipid metabolism. In humans, PPARα activation causes a decrease in plasma triglyceride (TG) levels, enhancement of high-density lipoprotein cholesterol (HDL-C) and simultaneous enhancement of very-low-density lipoprotein (VLDL) lipolysis, whereas PPARγ agonists act as insulin sensitizers and improve insulin resistance, which is very useful in patients with type 2 diabetes mellitus (T2DM)...
October 11, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29021325/high-density-lipoprotein-subclasses-coronary-artery-disease-and-cardiovascular-mortality
#13
Günther Silbernagel, Philipp Pagel, Volker Pfahlert, Bernd Genser, Hubert Scharnagl, Marcus E Kleber, Graciela Delgado, Haruna Ohrui, Andreas Ritsch, Tanja B Grammer, Wolfgang Koenig, Winfried März
BACKGROUND: The inverse relationship between HDL cholesterol and cardiovascular mortality is weakened in coronary artery disease (CAD). We aimed to investigate the associations of HDL particle concentrations with cardiovascular mortality and the impact of CAD on these associations. We also sought to comparatively evaluate HDL cholesterol and HDL particle concentrations in predicting cardiovascular mortality. METHODS: Total and subclass HDL particle concentrations were measured by nuclear magnetic resonance spectroscopy in 2290 participants of the LUdwigshafen RIsk and Cardiovascular Health study referred for coronary angiography...
October 11, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29020971/efficacy-and-safety-of-turmeric-and-curcumin-in-lowering-blood-lipid-levels-in-patients-with-cardiovascular-risk-factors-a-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Hong Ren, Huaidong Hu
BACKGROUND: Dyslipidemia is an important and common cardiovascular risk factor in the general population. The lipid-lowering effects of turmeric and curcumin are unconfirmed. We performed a meta-analysis to assess the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD). METHODS: A comprehensive literature search was conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases to identify randomized controlled trials (published as of November 2016) that assessed the effect of turmeric and curcumin on blood lipid levels including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)...
October 11, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29020293/dual-therapy-with-darunavir-and-ritonavir-plus-lamivudine-versus-triple-therapy-with-darunavir-and-ritonavir-plus-tenofovir-disoproxil-fumarate-and-emtricitabine-or-abacavir-and-lamivudine-for-maintenance-of-hiv-1-viral-suppression-randomised-open-label-non
#15
Federico Pulido, Esteban Ribera, María Lagarde, Ignacio Pérez-Valero, Rosario Palacios, José A Iribarren, Antoni Payeras, Pere Domingo, José Sanz, Miguel Cervero, Adrián Curran, Francisco J Rodríguez-Gómez, María J Téllez, Pablo Ryan, Pilar Barrufet, Hernando Knobel, Antonio Rivero, Belén Alejos, María Yllescas, José R Arribas
Background: Our objective was to assess the therapeutic non-inferiority of dual therapy with darunavir/ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus tenofovir disoproxil fumarate and emtricitabine or abacavir and lamivudine for maintenance of HIV-1 viral suppression. Methods: 48-week, multicenter, open-label, non-inferiority trial (margin 12%). Patients with HIV-1 RNA <50 copies/mL for ≥6 months on triple therapy with darunavir/ritonavir and two nucleos(t)ides (tenofovir disoproxil fumarate and emtricitabine or abacavir and lamivudine), with no resistance, were randomized to continue therapy (n=128) or switch to darunavir/ritonavir and lamivudine (n=129)...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019104/the-effect-of-boron-on-some-biochemical-parameters-in-experimental-diabetic-rats
#16
Selcen Cakir, Meryem Eren, Meryem Senturk, Zeynep Soyer Sarica
In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats. Sixty Wistar albino rats (200-250 g) were divided into six groups of ten. The groups received the following treatment: group 1, control group; group 2, 50 mg/kg (b...
October 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29017158/beneficial-effects-of-n-3-fatty-acids-on-cardiometabolic-and-inflammatory-markers-in-type-2-diabetes-mellitus-a-randomized-placebo-controlled-double-blind-clinical-trial
#17
Maryam Mazaherioun, Mahmoud Djalali, Fariba Koohdani, Mohammad Hassan Javanbakht, Mahnaz Zarei, Maani Beigy, Samaneh Ansari, Neda Rezvan, Ahmad Saedisomeolia
OBJECTIVE: To determine the effect of n-3 polyunsaturated fatty acids (n-3PUFAs) supplementation on circulatory resistin and monocyte chemoattractant 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. SUBJECTS AND METHODS: This was a ten-week, placebo-controlled, double-blind, randomized trial of n-3 PUFAs (2700 mg/day) vs. placebo (soft gels containing 900 mg of edible paraffin). Forty-four (44) T2DM patients were supplemented with n-3 PUFAs and another 44 patients received placebo (3 patients discontinued the trial)...
October 10, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29016475/relationship-between-physiological-off-ice-testing-on-ice-skating-and-game-performance-in-division-i-women-s-ice-hockey-players
#18
Michelle Boland, Emily M Miele, Katie Delude
The purpose was to identify off-ice testing variables that correlate to skating and game performance in Division I collegiate women ice hockey players. Twenty female, forward and defensive players (19.95 ± 1.35 yr) were assessed for weight, height, percent fat mass (%FAT), bone mineral density, predicted one repetition maximum (RM) absolute and relative (REL%) bench press (BP) and hex bar deadlift (HDL), lower body explosive power, anaerobic power, countermovement vertical jump (CMJ), maximum inspiratory pressure (MIP), and on-ice repeated skate sprint (RSS) performance...
October 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29016353/markers-influencing-the-presence-of-partial-clinical-remission-in-patients-with-newly-diagnosed-type-1-diabetes
#19
Aleksandra Pyziak, Agnieszka Zmyslowska, Katarzyna Bobeff, Beata Malachowska, Wojciech Fendler, Krystyna Wyka, Anna Baranowska-Jazwiecka, Malgorzata Szymanska, Agnieszka Szadkowska, Wojciech Mlynarski
BACKGROUND: The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D). METHODS: The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA1c) <7%. RESULTS: Partial CR was observed in 115/186 (61.83%) of patients...
October 10, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28993180/efficacy-and-safety-of-switching-from-boosted-protease-inhibitors-plus-emtricitabine-and-tenofovir-disoproxil-fumarate-regimens-to-single-tablet-darunavir-cobicistat-emtricitabine-and-tenofovir-alafenamide-at-48-weeks-in-adults-with-virologically-suppressed
#20
Chloe Orkin, Jean-Michel Molina, Eugenia Negredo, José R Arribas, Joseph Gathe, Joseph J Eron, Erika Van Landuyt, Erkki Lathouwers, Veerle Hufkens, Romana Petrovic, Simon Vanveggel, Magda Opsomer
BACKGROUND: Simplified regimens with reduced pill burden and fewer side-effects are desirable for people living with HIV. We investigated the efficacy and safety of switching to a single-tablet regimen of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide versus continuing a regimen of boosted protease inhibitor, emtricitabine, and tenofovir disoproxil fumarate. METHODS: EMERALD was a phase-3, randomised, active-controlled, open-label, international, multicentre trial, done at 106 sites across nine countries in North America and Europe...
October 5, 2017: Lancet HIV
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