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https://www.readbyqxmd.com/read/28634822/the-ratio-of-eicosapentaenoic-acid-epa-to-arachidonic-acid-may-be-a-residual-risk-marker-in-stable-coronary-artery-disease-patients-receiving-treatment-with-statin-following-epa-therapy
#1
Shigemasa Tani, Ken Nagao, Kenji Kawauchi, Tsukasa Yagi, Wataru Atsumi, Rei Matsuo, Atsushi Hirayama
BACKGROUND: We investigated the relationship between the eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio and non-high-density lipoprotein cholesterol (non-HDL-C) level, a major residual risk of coronary artery disease (CAD), in statin-treated CAD patients following EPA therapy. METHODS: We conducted a 6-month, prospective, randomized clinical trial to investigate the effect of the additional administration of EPA on the EPA/AA ratio and the serum non-HDL-C level in stable CAD patients receiving statin treatment...
June 20, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28634625/serum-antioxidant-capacity-biochemical-profile-and-body-composition-of-breast-cancer-survivors-in-a-randomized-mediterranean-dietary-intervention-study
#2
Maria Skouroliakou, D Grosomanidis, P Massara, C Kostara, P Papandreou, D Ntountaniotis, G Xepapadakis
PURPOSE: Increasing evidence suggests that Mediterranean Diet (MD) is correlated with reduced risk of breast cancer (BC) and cancer mortality, since it modifies patients' serum antioxidant capacity, body composition and biochemical parameters. The aim of the study was to investigate whether a dietary intervention based on MD has a beneficial effect on these factors. METHODS: In this intervention study, seventy female BC survivors were randomly assigned to (1) the intervention group (personalized dietary intervention based on MD) and (2) the control group (received the updated American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and ad libitum diet)...
June 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28634364/lipid-changes-8-years-post-gastric-bypass-in-adolescents-with-severe-obesity-fabs-5-study
#3
Amy S Shah, Todd Jenkins, Zhiqian Gao, Stephen R Daniels, Elaine M Urbina, Shelley Kirk, Robert Siegel, Thomas H Inge
OBJECTIVE: Severe obesity in adolescents is increasing and few effective treatments exist. Bariatric surgery is one option, but the extent to which surgery influences cardiovascular risk factors over time in youth is not clear. We hypothesized that Roux-en Y gastric bypass (RYGB) would be associated with sustained improvements in lipids over time (>5 years). PARTICIPANTS/METHODS: Youth who underwent RYGB from 2001-2007 were recruited for the Follow-up of Adolescent Bariatric Surgery-5+ (FABS-5+) in 2011-2014...
June 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28634189/reduced-platelet-count-but-no-major-platelet-function-abnormalities-are-associated-with-loss-of-function-atp-binding-cassette-1-abca1-gene-mutations
#4
Pietro Minuz, Alessandra Meneguzzi, Eti Alessandra Femia, Cristiano Fava, Stefano Calabria, Mariangela Scavone, Donatella Benati, Giovanni Poli, Carlo Zancanaro, Sebastiano Calandra, Tiziano Lucchi, Marco Cattaneo
Loss of function mutations of the the ATP-binding cassette-1 (ABCA1) gene are the cause of Tangier disease (TD) in homozygous subjects and familial HDL deficiency (FHD) in heterozygous subjects. These disorders are characterized by reduced plasma HDL-cholesterol and altered efflux of cholesterol from cells. Previous studies in TD patients and ABCA1(-/-) murine models reported defects in platelet count, morphology and function, but the issue is still controversial. We analysed three subjects with low to very low HDL cholesterol levels due to loss of function mutations of the ABCA1 gene...
June 20, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28632304/are-visceral-adiposity-index-and-lipid-accumulation-product-reliable-indices-for-metabolic-disturbances-in-patients-with-type-2-diabetes-mellitus
#5
Nebojsa Kavaric, Aleksandra Klisic, Ana Ninic
BACKGROUND: Visceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). METHODS: A total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled...
June 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28629169/association-between-six-cetp-polymorphisms-and-metabolic-syndrome-in-uyghur-adults-from-xinjiang-china
#6
Huixian Hou, Rulin Ma, Heng Guo, Jia He, Yunhua Hu, Lati Mu, Yizhong Yan, Jiaolong Ma, Shugang Li, Jingyu Zhang, Yusong Ding, Mei Zhang, Qiang Niu, Jiaming Liu, Shuxia Guo
OBJECTIVE: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the CETP gene polymorphisms and each component of MS. METHODS: A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected CETP polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method...
June 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28628560/genetic-coding-variants-in-the-niacin-receptor-hydroxyl-carboxylic-acid-receptor-2-and-response-to-niacin-therapy
#7
Sony Tuteja, Lu Wang, Richard L Dunbar, Jinbo Chen, Stephanie DerOhannessian, Santica M Marcovina, Marshall Elam, Ellis Lader, Daniel J Rader
OBJECTIVE: Niacin has been used for seven decades to modulate plasma lipids, but its mechanism of action is still unclear. We sought to determine whether variants in the niacin receptor gene, hydroxyl-carboxylic receptor 2 (HCAR2), are associated with lipid response to treatment. PARTICIPANTS AND METHODS: Coding variants, rs7314976 (p.R311C) and rs2454727 (p.M317I), were genotyped in 2067 participants from the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes (AIM-HIGH) trial...
June 16, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28628145/-relationship-between-glycemic-control-and-visceral-adiposity-index-among-the-patients-with-type-2-diabetes-mellitus
#8
Y Y Cao, X Tang, K X Sun, Z K Liu, X Xiang, J Juan, J Song, Q Z Duan, D J Zhaxi, Y N Hu, Y F Yang, M Y Shi, Y H Tian, S P Huang, X F Liu, N Li, J Li, T Wu, D F Chen, Y H Hu
OBJECTIVE: To explore the relationship between glycemic control and visceral adiposity index (VAI) among type 2 diabetes mellitus (T2DM) patients. METHODS: A community-based epidemiological field study for patients with T2DM aged ≥ 40 years was conducted in China.Every participant underwent physical examinations, biochemical tests of fasting glucose, glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and so on, and a questionnaire, including anthropometric characteristics, lifestyle, disease history, family history, and medication use...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627815/the-levels-of-serum-irisin-as-a-predictor-of-insulin-resistance-in-han-chinese-adults-with-metabolically-healthy-obesity
#9
Bo-Wei Liu, Fu-Zai Yin, Xi-Ming Qi, Dong-Mei Fan, Yue Zhang
BACKGROUND: The aim of this study was to evaluate serum irisin levels and analyze its related factors in Han adults with metabolically healthy obesity. METHODS: This cross-sectional study included 75 metabolically healthy, non-obese adults and 51 metabolically healthy, obese adults. Anthropometric measurements, including height, weight, waist circumference (WC), and blood pressure, were performed. All patients underwent an oral glucose tolerance test (OGTT) after 8 hours of fasting, and the levels of glucose, insulin, lipids, and serum irisin were measured...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627263/association-of-interleukin-1a-insertion-deletion-gene-polymorphism-and-possible-high-risk-factors-with-non-alcoholic-fatty-liver-disease-in-egyptian-patients
#10
Asmaa R Abdel-Hamed, Maivel H Ghattas, Noha M Mesbah, Samy M Saleh, Dina M Abo-Elmatty
CONTEXT: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression. OBJECTIVE: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations. METHODS: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured...
June 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28627187/-is-plasma-selenium-correlated-to-transthyretin-levels-in-critically-ill-patients
#11
Renata G B O N Freitas, Roberto Jose Negrão Nogueira, Silvia Maria Franciscato Cozzolino, Ana Carolina Junqueira Vasques, Matthew Thomas Ferreira, Gabriel Hessel
BACKGROUND: Selenium is an essential trace element, but critically ill patients using total parenteral nutrition (PN) do not receive selenium because this mineral is not commonly offered. Threfore, the eval uation of plasma selenium levels is very important for treating or preventing this deficiency. Recent studies have shown that transthyretin may reflect the selenium intake and could be considered a biomarker. However, this issue is still little explored in the literature. OBJECTIVE: This study aims to investigate the correlation of transthyretin with the plasma selenium of critically ill patients receiving PN...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28626208/posttraumatic-stress-disorder-eliminates-association-of-trkb-rs1187327-with-hdl-c-in-chinese-han-adolescents
#12
Ting Cao, Qiwei Guo, Mi Su, Yue Feng, Mei Fan, Yanjun Si, Nazakat H Memon, Jia Lin, Dingzhi Fang
Tropomyosin-related kinase receptor B (TrkB) has been observed to be a common player in posttraumatic stress disorder (PTSD) and the regulation of serum lipids levels. However, interplays of PTSD with TrkB on serum lipids levels have not been explored yet. This study was to investigate the interplays of PTSD and TrkB rs1187327 on serum lipid profiles. Variants of TrkB rs1187327 of 709 high school students were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses and verified by DNA sequencing...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28625710/effect-of-an-individualised-physical-exercise-program-on-lipid-profile-in-sedentary-patients-with-cardiovascular-risk-factors
#13
Francisco Javier Rubio Pérez, Luis Franco Bonafonte, Daiana Ibarretxe Guerediaga, Maria Pilar Oyon Belaza, Paola Ugarte Peyron
Physical exercise has become in an important tool in the reduction of cardiovascular risk. OBJECTIVES: To evaluate the effectiveness of an unsupervised physical exercise program that on the physical condition and the lipid profile. METHOD: The final sample included 49 sedentary men and women, who were non-smokers, with dyslipidaemia, overweight, and type1 obesity. The 4-month program included walking for 30-60minutes every day, and for three days a week, 30minutes of cycling at an intensity of 40-60% of maximum functional capacity, as well as isometric abdominals and static stretching...
June 15, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28625611/comparing-sf-36%C3%A2-scores-versus-biomarkers-to-predict-mortality-in-primary-cardiac-prevention-patients
#14
EDITORIAL
Rony Lahoud, Vasutakarn Chongthammakun, Yuping Wu, Nael Hawwa, Danielle M Brennan, Leslie Cho
BACKGROUND: Risk stratification plays an important role in evaluating patients with no known cardiovascular disease (CVD). Few studies have investigated health-related quality of life questionnaires such as the Medical Outcomes Study Short Form-36 (SF-36®) as predictive tools for mortality, particularly in direct comparison with biomarkers. Our objective is to measure the relative effectiveness of SF-36® scores in predicting mortality when compared to traditional and novel biomarkers in a primary prevention population...
June 15, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28625343/short-term-cooling-increases-serum-triglycerides-and-small-high-density-lipoprotein-levels-in-humans
#15
Geerte Hoeke, Kimberly J Nahon, Leontine E H Bakker, Sabine S C Norkauer, Donna L M Dinnes, Maaike Kockx, Laeticia Lichtenstein, Diana Drettwan, Anne Reifel-Miller, Tamer Coskun, Philipp Pagel, Fred P H T M Romijn, Christa M Cobbaert, Ingrid M Jazet, Laurent O Martinez, Leonard Kritharides, Jimmy F P Berbée, Mariëtte R Boon, Patrick C N Rensen
BACKGROUND: Cold exposure and β3-adrenergic receptor agonism, which both activate brown adipose tissue, markedly influence lipoprotein metabolism by enhancing lipoprotein lipase-mediated catabolism of triglyceride-rich lipoproteins and increasing plasma high-density lipoprotein (HDL) levels and functionality in mice. However, the effect of short-term cooling on human lipid and lipoprotein metabolism remained largely elusive. OBJECTIVE: The objective was to assess the effect of short-term cooling on the serum lipoprotein profile and HDL functionality in men...
May 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28625037/tumour-necrosis-factor-%C3%AE-and-risk-of-cardiovascular-disease-among-overfat-indonesian-adolescents
#16
Dian Caturini Sulistyoningrum, Rina Susilowati, Emy Huriyati, Ni Putu Diah Witari, Harry Freitag Luglio, Madarina Julia
BACKGROUND: Overfatness (overweight and obesity) is associated with an increased risk of cardiovascular disease, including elevated blood pressure, dyslipidaemia, and insulin resistance. Chronic inflammation may play a role in mediating these associations. OBJECTIVE: To investigate the association between plasma tumour necrosis factor-α and risk factors for cardiovascular disease among overweight and obese adolescents. METHODS AND STUDY DESIGN: This study was an observational analysis with a cross-sectional design for high school students in Yogyakarta, Indonesia...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28624686/genetic-factors-exist-behind-the-high-prevalence-of-reduced-high-density-lipoprotein-cholesterol-levels-in-the-roma-population
#17
Péter Pikó, Szilvia Fiatal, Zsigmond Kósa, János Sándor, Róza Ádány
BACKGROUND AND AIMS: Previous findings showed that reduced plasma high-density lipoprotein cholesterol (HDL-C) levels are more frequent in all age groups of the Hungarian Roma compared to the general population. It suggests that genetic factors may exist behind this phenomenon. Our present study was designed to test this hypothesis, i.e., to define whether genetic factors contribute to the higher prevalence of reduced HDL-C among Roma. Single nucleotide polymorphisms (N = 21) contributing to the variation in plasma HDL-C concentrations were analysed in the Hungarian Roma (N = 646) and general (N = 1542) populations...
May 26, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28624425/antiobesity-antioxidant-and-hepatoprotective-effects-of-diallyl-trisulphide-dats-alone-or-in-combination-with-orlistat-on-hfd-induced-obese-rats
#18
Sivakumar Annamalai, Lavanya Mohanam, Veena Raja, Alwin Dev, Venkataraman Prabhu
The increasing rate of obesity in the past years has become a worldwide concern and it causes many diseases. Even though, Orlistat, a synthetic anti-obesity drug approved by FDA, it causes severe side effects. DATS, a natural product from garlic have gained attention in many biological activities. The aim of the study is to determine the impact of Dially trisulpide (DATS) and its combination with Orlistat therapy on obese animals. 30 male Wistar rats (150-180g) were assigned into 5 groups (n=6). Group 1 rats received normal diet and Group 2 fed with high fat diet (HFD) for 14 weeks...
June 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28624096/a-multiregional-randomized-evaluation-of-the-lipid-modifying-efficacy-and-tolerability-of-anacetrapib-added-to-ongoing-statin-therapy-in-patients-with-hypercholesterolemia-or-low-high-density-lipoprotein-cholesterol
#19
Christie M Ballantyne, Sukrut Shah, Aditi Sapre, Tanya B Ashraf, Sandra C Tobias, Tayfun Sahin, Ping Ye, Yugang Dong, Wayne Huey-Heng Sheu, Duk-Hyun Kang, Paulo Roberto Ferreira Rossi, Yulia Moiseeva, Ignacio Rodriguez Briones, Amy O Johnson-Levonas, Yale B Mitchel
This phase 3, multiregional, randomized, double-blind, placebo-controlled study assessed the efficacy/safety profile of anacetrapib added to ongoing therapy with statin ± other lipid-modifying therapies in patients with hypercholesterolemia who were not at their low-density lipoprotein (LDL-C) goal (as per the National Cholesterol Education Program Adult Treatment Panel III guidelines) and in those with low high-density lipoprotein cholesterol (HDL-C). Patients on a stable dose of statin ± other lipid-modifying therapies and with LDL-C ≥70 to <115, ≥100 to <145, ≥130, or ≥160 mg/dl for very high, high, moderate, or low CHD risk or at LDL-C goal (per CHD risk category) with HDL-C ≤40 mg/dl were randomized in a ratio of 1:1 to anacetrapib 100 mg (n = 290) or placebo (n = 293) for 24 weeks, followed by a 12-week off-drug phase...
April 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28623739/high-density-lipoprotein-cholesterol-levels-are-associated-with-coronary-severity-but-not-with-outcomes-in-new-onset-patients-with%C3%A2-stable-coronary-artery-disease
#20
Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Ping Qing, Sha Li, Xi Zhao, Yan Zhang, Di Sun, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND AND AIMS: The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) levels in coronary artery disease (CAD) remains controversial. This study sought to reappraise the value of HDL-C in predicting the severity and outcomes of new-onset patients with stable CAD in Chinese populations. METHODS: A total of 4205 new-onset patients with stable CAD who received coronary angiography were enrolled to analyze the relation of HDL-C to coronary severity and major adverse cardiovascular events (MACEs)...
June 7, 2017: Atherosclerosis
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