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JOURNAL ARTICLE
Hai-Bin Zhu, Chuan-Yang Jin, Hang Zhou, Zheng Sun, Qian Xu, Cheng-Xuan Lu, Zi-Qiu Zhou, Jia-Wei Xiong, Jian-Bin Zhang
OBJECTIVES: To study the regularity of central response to thermal needle stimulation of "Zusanli" (ST36) at different temperature, and to analyze the temperature difference of central responses. METHODS: Six male C57BL/6j adult mice were used in the present study. For observing activities of neurons in the hindlimb region of left primary somatosensory cortex (S1HL, A/P=0.46 mm, M/L=1.32 mm, D/V=-0.14 mm) by using a fast high-resolution miniature two-photon microscopy (FHIRM-TPM), the mice were anesthetized with 3% isoflurane (inhalation), with its head fixed in a stereotaxic apparatus, then, adeno-associated virus (AAV-hSyn-GCaMP6f-WPRE-hGHpA, for showing intracellular calcium transients in neurons transfected) was injected into the left S1HL region using a micro-syringe after scalp surgical operation...
April 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
#22
JOURNAL ARTICLE
J P Torres, C Ibañez, R Valenzuela, S Bahamondes, V De la Maza, M Villarroel, P Coria, V Contardo, A M Álvarez, M Zubieta, V Gutierrez, K Ducasse, D Martínez, M E Santolaya
OBJECTIVES: To validate the efficacy and safety of withholding antimicrobial therapy in a new cohort of children with cancer and febrile neutropenia (FN) having a demonstrated viral respiratory tract infection (RTI). METHODS: Prospective, multicenter, non-inferiority, randomized study, approved by the ethical committee, in children presenting with FN at seven hospitals in Chile, evaluated at admission for diagnosis of bacterial and viral pathogens. Children who were positive for a respiratory virus (RV), negative for a bacterial pathogen and had a favorable evolution after 48-72 hours of antimicrobial therapy were randomized to either maintain or withhold antimicrobial therapy...
April 20, 2024: Clinical Microbiology and Infection
#23
JOURNAL ARTICLE
Ayesha Dholakia, Kendall J Burdick, Catherine Kreatsoulas, Michael C Monuteaux, Jennifer Tsai, S V Subramanian, Eric W Fleegler
BACKGROUND: Redlining began in the 1930s with the Home Owners' Loan Corporation (HOLC); this discriminatory practice limited mortgage availability and reinforced concentrated poverty that still exists today. It is important to understand the potential health implications of this federally sanctioned segregation. OBJECTIVE: To examine the relationship between historical redlining policies and present-day nonsuicide firearm fatalities. DESIGN: Maps from the HOLC were overlaid with incidence of nonsuicide firearm fatalities from 2014 to 2022...
April 23, 2024: Annals of Internal Medicine
#24
JOURNAL ARTICLE
Ransheng Wang, Haimei Shi, Ting Xie, Zhigang Sun
The impact of non-Born-Oppenheimer couplings on the isotopic effects in the reaction of the Cl(2 P) atom with the HD ( v = 0, j = 0) molecule is investigated with our recently developed nonadiabatic time-independent quantum scattering methods, where the full open-shell characteristics are included in the six-state model, and also with the recently developed two-state model solving by time-independent methods, where part of the open-shell characteristic is included. The same reaction is also calculated with the simple adiabatic model using the lowest adiabatic potential energy surface...
April 22, 2024: Journal of Physical Chemistry. A
#25
JOURNAL ARTICLE
Obadiah Opoku-Bamfoh, Sandra Abankwa Kwarteng, Frema A N Owusu, Raphael Akpanya, Kelvin A Mensah, Mercy Badu, Fred Y Gyamfi, Victoria Sogbo, Ebenezer J D Belford, Abena Boakye, Henry Morgan Morrison, Patrick K Obuam, Sylvester Coleman
BACKGROUND OBJECTIVES: Widespread pyrethroid resistance and plastic-feeding behaviour of most malaria vectors across Africa threaten the efficacy of current insecticide-based vector control interventions like Insecticide-Treated Nets (ITNs) and Indoor Residual Spraying (IRS). This study examined the larvicidal activity ofMorinda citrifolia against Anopheles gambiae larvae and the repellent properties of Morinda citrifolia (Noni), Moringa oleifera (Moringa), and Ocimum basilicum (Basil) as complementary vector control tools against Anopheles gambiae sensu lato (s...
January 1, 2024: Journal of Vector Borne Diseases
#26
JOURNAL ARTICLE
Vinicius S Izquierdo, Bruno I Cappellozza, João V L Silva, Giovanna C M Santos, André Miranda, João H J Bittar, Autumn Pickett, Shea Mackey, Reinaldo F Cooke, João M B Vendramini, Philipe Moriel
This study evaluated the effects of maternal supplementation of a Bacillus-based direct-fed microbial (DFM) on the physiology and growth performance of Bos indicus-influenced cow-calf pairs. On day 0 (~139 d before expected calving date), 72 fall-calving, Brangus crossbred beef heifers (20 to 22 mo of age) pregnant with first offspring were stratified by their initial body weight (BW; 431 ± 31 kg) and body condition score (BCS; 6.0 ± 0.36; scale 1 to 9), and randomly allocated into 1 of 12 bahiagrass pastures (1 ha and 6 heifers per pasture)...
April 22, 2024: Journal of Animal Science
#27
JOURNAL ARTICLE
R Paleckiene, D Zaliaduonyte, V Dambrauskiene, J Macijauskiene
BACKGROUND: The well-being of individuals with chronic heart failure (HF) is significantly influenced by their health-related quality of life (HRQoL), which serves as a crucial measure indicating how HF affects their daily activities. Monitoring programs aimed at reducing the number of hospitalizations and improving functional conditions are currently being offered to patients with chronic HF. THE OBJECTIVE: To examine the long-term health-related quality of life changes in patients with heart failure enrolled in a follow-up program after hospitalization and to evaluate the factors associated with quality of life of patients with heart failure...
2024: Frontiers in Cardiovascular Medicine
#28
JOURNAL ARTICLE
V Baron, S T Sommer, D J Fiegle, A-K M Pfeuffer, R Peyronnet, T Volk, T Seidel
Introduction: Recent advances have enabled organotypic culture of beating human myocardial slices that are stable for weeks. However, human myocardial samples are rare, exhibit high variability and frequently originate from diseased hearts. Thus, there is a need to adapt long-term slice culture for animal myocardium. When applied to animal cardiac slices, studies in healthy or genetically modified myocardium will be possible. We present the culture of slices from rabbit hearts, which resemble the human heart in microstructure, electrophysiology and excitation-contraction coupling...
2024: Frontiers in Bioengineering and Biotechnology
#29
Mai D Ton, Dao V Phuong, Pham Q Tho, Nguyen T Dung, Tran A Tuan, Nguyen T Thien
Ruptured aneurysmal subarachnoid hemorrhage associated with multiple basilar trunk aneurysms represents a rare clinical condition. Endovascular intervention stands as the preferred therapeutic approach. We present the case of a 35-year-old patient with subarachnoid hemorrhage and three consecutive basilar trunk aneurysms. Utilizing a flow-diverter stent, we achieved simultaneous occlusion of all 3 aneurysms, performed 2 hours post dual antiplatelet therapy (comprising salicylic acid 300 mg and ticagrelor 180 mg)...
July 2024: Radiology Case Reports
#30
Amy C Moreno, Erin E Watson, Laia Humbert-Vidan, Douglas E Peterson, Lisanne V van Dijk, Teresa Guerrero Urbano, Lisa Van den Bosch, Andrew J Hope, Matthew S Katz, Frank J P Hoebers, Ruth A Aponte Wesson, James E Bates, Paolo Bossi, Adeyinka F Dayo, Mélanie Doré, Eduardo Rodrigues Fregnani, Thomas J Galloway, Daphna Y Gelblum, Issa A Hanna, Christina E Henson, Sudarat Kiat-Amnuay, Anke Korfage, Nancy Y Lee, Carol M Lewis, Charlotte Duch Lynggaard, Antti A Mäkitie, Marco Magalhaes, Yvonne M Mowery, Carles Muñoz-Montplet, Jeffrey N Myers, Ester Orlandi, Jaymit Patel, Jillian M Rigert, Deborah Saunders, Jonathan D Schoenfeld, Ugur Selek, Efsun Somay, Vinita Takiar, Juliette Thariat, Gerda M Verduijn, Alessandro Villa, Nick West, Max J H Witjes, Alex Won, Mark E Wong, Christopher M K L Yao, Simon W Young, Kamal Al-Eryani, Carly E A Barbon, Doke J M Buurman, François J Dieleman, Theresa M Hofstede, Abdul Ahad Khan, Adegbenga O Otun, John C Robinson, Lauren Hum, Jorgen Johansen, Rajesh Lalla, Alexander Lin, Vinod Patel, Richard J Shaw, Mark S Chambers, Daniel Ma, Mabi Singh, Noam Yarom, Abdallah Sherif Radwan Mohamed, Katherine A Hutcheson, Stephen Y Lai, Clifton David Fuller
PURPOSE: Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ...
April 9, 2024: medRxiv
#31
JOURNAL ARTICLE
L Brilli, P Toscano, F Carotenuto, S Di Lonardo, P Di Tommasi, V Magliulo, A Manco, L Vitale, A Zaldei, B Gioli
Landfills play a key role as greenhouse gas (GHGs) emitters, and urgently need assessment and management plans development to swiftly reduce their climate impact. In this context, accurate emission measurements from landfills under different climate and management would reduce the uncertainty in emission accounting. In this study, more than one year of long-term high-frequency data of CO2 and CH4 fluxes were collected in two Italian landfills (Giugliano and Case Passerini) with contrasting management (gas recovery VS no management) using eddy covariance (EC), with the aim to i) investigate the relation between climate drivers and CO2 and CH4 fluxes at different time intervals and ii) to assess the overall GHG balances including the biogas extraction and energy recovery components...
April 30, 2024: Heliyon
#32
JOURNAL ARTICLE
[Short-term efficacy and safety of cardiac contractility modulation in patients with heart failure].
Y K Guo, S Shang, T H Sun, Y Q Fan, Jiasuoer Xiaokereti, Kela TuErhong Zu, X Yang, L Zhang, Y D Li, Y M Lu, J H Zhang, Q Xing, X H Zhou, B P Tang
Objective: To investigate the short-term efficacy and safety of cardiac contractility modulation (CCM) in patients with heart failure. Methods: This was a cross-sectional study of patients with heart failure who underwent CCM placement at the First Affiliated Hospital of Xinjiang Medical University from February to June 2022. With a follow-up of 3 months, CCM sensation, impedance, percent output, and work time were monitored, and patients were compared with pre-and 3-month postoperative left ventricular ejection fraction (LVEF) values, and 6-minute walk test distance and New York Heart Association (NYHA) cardiac function classification, and the occurrence of complications was recorded...
April 24, 2024: Zhonghua Xin Xue Guan Bing za Zhi
#33
JOURNAL ARTICLE
V Guido, Y Pontet, V López, C Olano
INTRODUCTION AND AIMS: Irritable bowel syndrome (IBS) is one of the most frequent functional gastrointestinal disorders. Prevalence worldwide is estimated at 11%. There is little information on the prevalence of the other functional bowel disorders (FBDs). Our aim was to establish the prevalence of IBS and other FBDs according to the Rome IV criteria, in Uruguay. MATERIALS AND METHODS: An observational, population-based prevalence study was conducted. Data were collected through an online questionnaire, utilizing the Rome IV criteria...
April 20, 2024: Revista de Gastroenterología de México
#34
JOURNAL ARTICLE
Elizabeth Brammer-Robbins, Mohammad-Zaman Nouri, Emily K Griffin, Juan J Aristizabal-Henao, Nancy D Denslow, John A Bowden, Iske V Larkin, Christopher J Martyniuk
Florida manatees (Trichechus manatus latirostris) are protected as a threatened species, and data are lacking regarding their reproductive physiology. This study aimed to (1) quantify plasma steroid hormones in Florida manatees from two field sites, Crystal River and Indian River Lagoon, at different gestational stages and to (2) identify individual lipids associated with pregnancy status. Ultra-high performance liquid chromatography-tandem mass spectrometric analysis was used to measure plasma steroid hormones and lipids...
April 3, 2024: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
#35
JOURNAL ARTICLE
Siliang Wu, Dan Li, Hanke Li, Qi-Zhi Su, Jinxin Liang, Jianguo Zheng, Huai-Ning Zhong, Ben Dong
The recycling of polyethylene terephthalate (PET) stands as an effective strategy for mitigating plastic pollution and reducing resource waste. The study aimed to investigate the characterization and elimination efficiency of volatile organic compounds (VOCs) present in rPET at various recycling stages using comprehensive two-dimensional gas chromatography-quadrupole-time-of-flight-mass spectrometry coupled with chemometrics. The results revealed that 52, 135, 95, 44, and 33 VOCs, mostly classified into three chemical groups, were tentatively identified in virgin - PET (v-PET), cold water washed - rPET (C-rPET), decontaminated - rPET (D-rPET), melt-extruded - rPET (M-rPET), and solid-state polycondensation - rPET (S-rPET), respectively...
April 20, 2024: Waste Management
#36
JOURNAL ARTICLE
M C Ramaboli, S Ocvirk, M Khan Mirzaei, B L Eberhart, M Valdivia-Garcia, A Metwaly, K Neuhaus, G Barker, J Ru, L T Nesengani, D Mahdi-Joest, A S Wilson, S K Joni, D C Layman, J Zheng, R Mandal, Q Chen, M R Perez, S Fortuin, B Gaunt, D Wishart, B Methé, D Haller, J V Li, L Deng, R Swart, S J D O'Keefe
Transition from traditional high-fiber to Western diets in urbanizing communities of Sub-Saharan Africa is associated with increased risk of non-communicable diseases (NCD), exemplified by colorectal cancer (CRC) risk. To investigate how urbanization gives rise to microbial patterns that may be amenable by dietary intervention, we analyzed diet intake, fecal 16 S bacteriome, virome, and metabolome in a cross-sectional study in healthy rural and urban Xhosa people (South Africa). Urban Xhosa individuals had higher intakes of energy (urban: 3,578 ± 455; rural: 2,185 ± 179 kcal/d), fat and animal protein...
April 20, 2024: Nature Communications
#37
REVIEW
Kevin Struhl
Enhancers are the key regulators of other DNA-based processes by virtue of their unique ability to generate nucleosome-depleted regions in a highly regulated manner. Enhancers regulate cell-type-specific transcription of tRNA genes by RNA polymerase III (Pol III). They are also responsible for the binding of the origin replication complex (ORC) to DNA replication origins, thereby regulating origin utilization, replication timing, and replication-dependent chromosome breaks. Additionally, enhancers regulate V(D)J recombination by increasing access of the recombination-activating gene (RAG) recombinase to target sites and by generating non-coding enhancer RNAs and localized regions of trimethylated histone H3-K4 recognized by the RAG2 PHD domain...
April 19, 2024: Trends in Genetics: TIG
#38
JOURNAL ARTICLE
D Adams, P Cintas, G Solé, C Tard, C Labeyrie, A Echaniz-Laguna, C Cauquil, Y Pereon, L Magy, R Juntas Morales, J C Antoine, E Lagrange, P Petiot, M Mallaret, B Francou, A Guiochon-Mantel, A Coste, O Demarcq, C Geffroy, V Famelart, J Rudant, M Bartoli, E Donal, O Lairez, J C Eicher, M Kharoubi, S Oghina, J N Trochu, J Inamo, G Habib, F Roubille, A Hagège, F Morio, E Cariou, J Adda, M S Slama, P Charron, V Algalarrondo, T Damy, S Attarian
OBJECTIVE: We aimed to describe characteristics of patients with ATTR variant polyneuropathy (ATTRv-PN) and ATTRv-mixed and assess the real-world use and safety profile of tafamidis meglumine 20mg. METHODS: Thirty-eight French hospitals were invited. Patient files were reviewed to identify clinical manifestations, diagnostic methods, and treatment compliance. RESULTS: Four hundred and thirteen patients (296 ATTRv-PN, 117 ATTRv-mixed) were analyzed...
April 19, 2024: Revue Neurologique
#39
JOURNAL ARTICLE
Anna Catharina V Armond, Kelly D Cobey, David Moher
Research integrity is guided by a set of principles to ensure research reliability, and rigor. It serves as a pillar to uphold society's trust in science and foster scientific progress. However, over the past two decades, a surge in research integrity concerns, including fraudulent research, reproducibility challenges, and questionable practices, has raised critical questions about the reliability of scientific outputs, particularly in biomedical research. In the biomedical sciences, any breaches in research integrity could potentially lead to a domino effect impacting patient care, medical interventions, and the broader implementation of healthcare policies...
April 18, 2024: Journal of Clinical Epidemiology
#40
JOURNAL ARTICLE
Udita Mandal, M Suman, J Dutta, V Dixit, D S Suman
Mosquito surveillance for vector-borne disease management relies on traditional morphological and molecular techniques, which are tedious, time-consuming, and costly. The present study describes a simple and efficient recording device that analyzes mosquito sound to estimate species composition, male-female ratio, fed-unfed status, and harmonic convergence interaction using fundamental frequency (F0 ) bandwidth, harmonics, amplitude, and combinations of these parameters. The study examined a total of 19 mosquito species, including 3 species of Aedes, 7 species of Anopheles, 1 species of Armigeres, 5 species of Culex, 1 species of Hulecoetomyia, and 2 species of Mansonia...
April 18, 2024: Acta Tropica
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