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https://www.readbyqxmd.com/read/28212374/the-effect-of-body-mass-index-at-diagnosis-on-clinical-outcome-in-children-with-newly-diagnosed-acute-lymphoblastic-leukemia
#1
H M Eissa, Y Zhou, J C Panetta, E K Browne, S Jeha, C Cheng, M V Relling, D Campana, C-H Pui, H Inaba
The impact of body mass index (BMI) at diagnosis on treatment outcome in children with acute lymphoblastic leukemia (ALL) is controversial. We studied 373 children with ALL enrolled on the Total XV study, which prospectively used minimal residual disease (MRD) for risk assignment. MRD on day 19 and at the end of remission induction (day 46), cumulative incidence of relapse/refractory disease (CIR), event-free survival (EFS) and overall survival (OS) were evaluated using sets of four, three and two subgroups based on BMI at diagnosis, along with BMI percentile change during remission induction...
February 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28212067/the-treatment-of-severe-childhood-aggression-study-12-weeks-of-extended-blinded-treatment-in-clinical-responders
#2
Robert L Findling, Lisa Townsend, Nicole V Brown, L Eugene Arnold, Kenneth D Gadow, David J Kolko, Nora K McNamara, Devin S Gary, Dana B Kaplin, Cristan A Farmer, Heidi Kipp, Craig Williams, Eric M Butter, Oscar G Bukstein, Robert Rice, Kristin Buchan-Page, Brooke S G Molina, Michael G Aman
OBJECTIVES: Previous "Treatment of Severe Childhood Aggression" (TOSCA) reports demonstrated that many children with severe physical aggression and attention-deficit/hyperactivity disorder (ADHD) responded well to two randomized treatments (parent training [PT]+stimulant+placebo = Basic vs. PT+stimulant+risperidone = Augmented) for 9 weeks. An important clinical question is whether these favorable outcomes are maintained over longer times. METHODS: Clinical responders to the 9-week trial (n = 103/168), defined as Clinical Global Impressions (CGI)-Improvement of much/very much improved plus substantial reduction in parent ratings of disruptiveness, were followed another 12 weeks (21 weeks total) while remaining on blinded treatment...
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28211941/upfront-window-vincristine-irinotecan-treatment-of-high-risk-hepatoblastoma-a-report-from-the-children-s-oncology-group-ahep0731-study-committee
#3
Howard M Katzenstein, Wayne L Furman, Marcio H Malogolowkin, Mark D Krailo, M Beth McCarville, Alexander J Towbin, Greg M Tiao, Milton J Finegold, Sarangarajan Ranganathan, Stephen P Dunn, Max R Langham, Eugene D McGahren, Carlos Rodriguez-Galindo, Rebecka L Meyers
BACKGROUND: The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy of novel agents. Herein, the authors report the response rate to the combination of vincristine (V) and irinotecan (I) and the outcome of patients with high-risk hepatoblastoma. METHODS: Patients with newly diagnosed metastatic hepatoblastoma or those with a serum α-fetoprotein (AFP) level <100 ng/mL were eligible...
February 17, 2017: Cancer
https://www.readbyqxmd.com/read/28211889/clinical-utility-of-the-revised-international-staging-system-in-unselected-patients-with-newly-diagnosed-and-relapsed-multiple-myeloma
#4
N Tandon, S V Rajkumar, B LaPlant, A Pettinger, M Q Lacy, A Dispenzieri, F K Buadi, M A Gertz, S R Hayman, N Leung, R S Go, D Dingli, P Kapoor, Y Lin, Y L Hwa, A L Fonder, M A Hobbs, S R Zeldenrust, J A Lust, W I Gonsalves, S J Russell, S K Kumar
We analyzed the utility of Revised International staging system (RISS) in an unselected cohort of newly diagnosed multiple myeloma (NDMM; cohort 1), and relapsed/refractory multiple myeloma (RRMM; cohort 2) patients. Cohort 1 included 1900 patients seen within 90 days of diagnosis, from 2005 to 2015, while cohort 2 had 887 patients enrolled in 23 clinical trials at Mayo Clinic. The overall survival (OS) and progression-free survival (PFS) was calculated from the time since diagnosis or trial registration. The median estimated follow up was 5 and 2...
February 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28211722/measurement-of-the-b-quark-production-cross-section-in-7-and-13%C3%A2-tev-pp-collisions
#5
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, W Baldini, R J Barlow, C Barschel, S Barsuk, W Barter, M Baszczyk, V Batozskaya, B Batsukh, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, L J Bel, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, J Benton, A Berezhnoy, R Bernet, A Bertolin, F Betti, M-O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, T Bird, A Birnkraut, A Bitadze, A Bizzeti, T Blake, F Blanc, J Blouw, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, W Bonivento, A Borgheresi, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, M Britsch, T Britton, J Brodzicka, E Buchanan, C Burr, A Bursche, J Buytaert, S Cadeddu, R Calabrese, M Calvi, M Calvo Gomez, A Camboni, P Campana, D Campora Perez, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, L Castillo Garcia, M Cattaneo, Ch Cauet, G Cavallero, R Cenci, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S-F Cheung, V Chobanova, M Chrzaszcz, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, V Coco, J Cogan, E Cogneras, V Cogoni, L Cojocariu, G Collazuol, P Collins, A Comerma-Montells, A Contu, A Cook, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, S Cunliffe, R Currie, C D'Ambrosio, F Da Cunha Marinho, E Dall'Occo, J Dalseno, P N Y David, A Davis, O De Aguiar Francisco, K De Bruyn, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C-T Dean, D Decamp, M Deckenhoff, L Del Buono, M Demmer, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, A Dovbnya, K Dreimanis, L Dufour, G Dujany, K Dungs, P Durante, R Dzhelyadin, A Dziurda, A Dzyuba, N Déléage, S Easo, M Ebert, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, Ch Elsasser, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, R Fay, D Fazzini, D Ferguson, V Fernandez Albor, A Fernandez Prieto, F Ferrari, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiore, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, K Fohl, M Fontana, F Fontanelli, D C Forshaw, R Forty, V Franco Lima, M Frank, C Frei, J Fu, E Furfaro, C Färber, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, P J Garsed, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, M Grabalosa Gándara, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, P Griffith, L Grillo, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, S Hall, B Hamilton, X Han, S Hansmann-Menzemer, N Harnew, S T Harnew, J Harrison, M Hatch, J He, T Head, A Heister, K Hennessy, P Henrard, L Henry, J A Hernando Morata, E van Herwijnen, M Heß, A Hicheur, D Hill, C Hombach, H Hopchev, W Hulsbergen, T Humair, M Hushchyn, N Hussain, D Hutchcroft, M Idzik, P Ilten, R Jacobsson, A Jaeger, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, W Kanso, M Karacson, J M Kariuki, S Karodia, M Kecke, M Kelsey, I R Kenyon, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, T Kirn, S Klaver, K Klimaszewski, S Koliiev, M Kolpin, I Komarov, R F Koopman, P Koppenburg, A Kosmyntseva, A Kozachuk, M Kozeiha, L Kravchuk, K Kreplin, M Kreps, P Krokovny, F Kruse, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, K Kurek, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, D Lambert, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, J van Leerdam, J-P Lees, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, Y Li, T Likhomanenko, R Lindner, C Linn, F Lionetto, B Liu, X Liu, D Loh, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, O Maev, K Maguire, S Malde, A Malinin, T Maltsev, G Manca, G Mancinelli, P Manning, J Maratas, J F Marchand, U Marconi, C Marin Benito, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, D Martins Tostes, L M Massacrier, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, B Maurin, A Mazurov, M McCann, J McCarthy, A McNab, R McNulty, B Meadows, F Meier, M Meissner, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, M-N Minard, D S Mitzel, A Mogini, J Molina Rodriguez, I A Monroy, S Monteil, M Morandin, P Morawski, A Mordà, M J Morello, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, M Mussini, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, A D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Novoselov, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, J M Otalora Goicochea, A Otto, P Owen, A Oyanguren, P R Pais, A Palano, F Palombo, M Palutan, J Panman, A Papanestis, M Pappagallo, L L Pappalardo, W Parker, C Parkes, G Passaleva, A Pastore, G D Patel, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, P Perret, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, M Pikies, D Pinci, A Pistone, A Piucci, S Playfer, M Plo Casasus, T Poikela, F Polci, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, A Popov, D Popov, B Popovici, S Poslavskii, C Potterat, E Price, J D Price, J Prisciandaro, A Pritchard, C Prouve, V Pugatch, A Puig Navarro, G Punzi, W Qian, R Quagliani, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, G Raven, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, V Rives Molina, P Robbe, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, P Rodriguez Perez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, J W Ronayne, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schlupp, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, K Schubert, M Schubiger, M-H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, I Shapoval, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, A Shires, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, E Smith, I T Smith, J Smith, M Smith, H Snoek, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, S Sridharan, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, S Stevenson, S Stoica, S Stone, B Storaci, S Stracka, M Straticiuc, U Straumann, L Sun, W Sutcliffe, K Swientek, V Syropoulos, M Szczekowski, T Szumlak, S T'Jampens, A Tayduganov, T Tekampe, M Teklishyn, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, S Topp-Joergensen, F Toriello, E Tournefier, S Tourneur, K Trabelsi, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Ustyuzhanin, U Uwer, C Vacca, V Vagnoni, A Valassi, S Valat, G Valenti, A Vallier, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, M Vernet, M Vesterinen, B Viaud, D Vieira, M Vieites Diaz, X Vilasis-Cardona, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, C Wallace, R Wallace, J Walsh, J Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M P Williams, M Williams, T Williams, F F Wilson, J Wimberley, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wraight, S Wright, K Wyllie, Y Xie, Z Xing, Z Xu, Z Yang, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, Y Zhang, A Zhelezov, Y Zheng, A Zhokhov, X Zhu, V Zhukov, S Zucchelli
Measurements of the cross section for producing b quarks in the reaction pp→bb[over ¯]X are reported in 7 and 13 TeV collisions at the LHC as a function of the pseudorapidity η in the range 2<η<5 covered by the acceptance of the LHCb experiment. The measurements are done using semileptonic decays of b-flavored hadrons decaying into a ground-state charmed hadron in association with a muon. The cross sections in the covered η range are 72.0±0.3±6.8 and 154.3±1.5±14.3  μb for 7 and 13 TeV...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211717/isomeric-character-of-the-lowest-observed-4-state-in-44-s
#6
J J Parker, I Wiedenhöver, P D Cottle, J Baker, D McPherson, M A Riley, D Santiago-Gonzalez, A Volya, V M Bader, T Baugher, D Bazin, A Gade, T Ginter, H Iwasaki, C Loelius, C Morse, F Recchia, D Smalley, S R Stroberg, K Whitmore, D Weisshaar, A Lemasson, H L Crawford, A O Macchiavelli, K Wimmer
Previous experiments observed a 4^{+} state in the N=28 nucleus ^{44}S and suggested that this state may exhibit a hindered E2-decay rate, inconsistent with being a member of the collective ground state band. We populate this state via two-proton knockout from a beam of exotic ^{46}Ar projectiles and measure its lifetime using the recoil distance method with the GRETINA γ-ray spectrometer. The result, 76(14)_{stat}(20)_{syst}  ps, implies a hindered transition of B(E2;4^{+}→2_{1}^{+})=0.61(19) single-particle or Weisskopf units strength and supports the interpretation of the 4^{+} state as a K=4 isomer, the first example of a high-K isomer in a nucleus of such low mass...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211706/observation-of-d-0-%C3%A2-%C3%AF-0-%C3%AE-and-search-for-cp-violation-in-radiative-charm-decays
#7
T Nanut, A Zupanc, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, P Behera, V Bhardwaj, J Biswal, A Bondar, A Bozek, M Bračko, T E Browder, D Červenkov, V Chekelian, A Chen, B G Cheon, R Chistov, K Cho, S-K Choi, Y Choi, D Cinabro, N Dash, S Di Carlo, Z Doležal, D Dutta, S Eidelman, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, B Golob, K Hayasaka, H Hayashii, W-S Hou, T Iijima, K Inami, G Inguglia, A Ishikawa, Y Iwasaki, W W Jacobs, I Jaegle, D Joffe, K K Joo, T Julius, A B Kaliyar, K H Kang, T Kawasaki, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, P Krokovny, T Kuhr, R Kulasiri, A Kuzmin, Y-J Kwon, J S Lange, I S Lee, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyata, R Mizuk, G B Mohanty, H K Moon, M Nakao, K J Nath, M Nayak, N K Nisar, S Nishida, S Ogawa, S Okuno, P Pakhlov, G Pakhlova, B Pal, C-S Park, C W Park, H Park, S Paul, T K Pedlar, L Pesántez, R Pestotnik, M Petrič, L E Piilonen, K Prasanth, C Pulvermacher, J Rauch, M Ritter, A Rostomyan, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, E Solovieva, S Stanič, M Starič, J F Strube, J Stypula, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, S Uno, Y Ushiroda, G Varner, A Vinokurova, V Vorobyev, A Vossen, C H Wang, M-Z Wang, P Wang, Y Watanabe, E Widmann, E Won, J Yamaoka, Y Yamashita, J Yelton, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov
We report the first observation of the radiative charm decay D^{0}→ρ^{0}γ and the first search for CP violation in decays D^{0}→ρ^{0}γ, ϕγ, and K[over ¯]^{*0}(892)γ, using a data sample of 943  fb^{-1} collected with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. The branching fraction is measured to be B(D^{0}→ρ^{0}γ)=(1.77±0.30±0.07)×10^{-5}, where the first uncertainty is statistical and the second is systematic. The obtained CP asymmetries A_{CP}(D^{0}→ρ^{0}γ)=+0...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211705/small-x-asymptotics-of-the-quark-helicity-distribution
#8
Yuri V Kovchegov, Daniel Pitonyak, Matthew D Sievert
We construct a numerical solution of the small-x evolution equations derived in our recent work [J. High Energy Phys. 01 (2016) 072.JHEPFG1029-847910.1007/JHEP01(2016)072] for the (anti)quark transverse momentum dependent helicity TMDs and parton distribution functions (PDFs) as well as the g_{1} structure function. We focus on the case of large N_{c}, where one finds a closed set of equations. Employing the extracted intercept, we are able to predict directly from theory the behavior of the quark helicity PDFs at small x, which should have important phenomenological consequences...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211704/observation-of-classical-quantum-crossover-of-1-f-flux-noise-and-its-paramagnetic-temperature-dependence
#9
C M Quintana, Yu Chen, D Sank, A G Petukhov, T C White, Dvir Kafri, B Chiaro, A Megrant, R Barends, B Campbell, Z Chen, A Dunsworth, A G Fowler, R Graff, E Jeffrey, J Kelly, E Lucero, J Y Mutus, M Neeley, C Neill, P J J O'Malley, P Roushan, A Shabani, V N Smelyanskiy, A Vainsencher, J Wenner, H Neven, John M Martinis
By analyzing the dissipative dynamics of a tunable gap flux qubit, we extract both sides of its two-sided environmental flux noise spectral density over a range of frequencies around 2k_{B}T/h≈1  GHz, allowing for the observation of a classical-quantum crossover. Below the crossover point, the symmetric noise component follows a 1/f power law that matches the magnitude of the 1/f noise near 1 Hz. The antisymmetric component displays a 1/T dependence below 100 mK, providing dynamical evidence for a paramagnetic environment...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211593/higher-infliximab-trough-levels-are-associated-with-perianal-fistula-healing-in-patients-with-crohn-s-disease
#10
A J Yarur, V Kanagala, D J Stein, F Czul, M A Quintero, D Agrawal, A Patel, K Best, C Fox, K Idstein, M T Abreu
BACKGROUND: Infliximab has been found to be efficacious in the treatment of fistulas in the setting of Crohn's disease, even though some patients do not benefit from therapy. AIM: To assess the correlation between perianal fistula healing and trough levels of infliximab. METHODS: In this cross-sectional study, we identified patients with Crohn's disease who had perianal fistulas and were treated with infliximab for at least 24 weeks. We excluded patients who underwent a faecal diversion procedure or proctectomy...
February 17, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28211517/edge-currents-shunt-the-insulating-bulk-in-gapped-graphene
#11
M J Zhu, A V Kretinin, M D Thompson, D A Bandurin, S Hu, G L Yu, J Birkbeck, A Mishchenko, I J Vera-Marun, K Watanabe, T Taniguchi, M Polini, J R Prance, K S Novoselov, A K Geim, M Ben Shalom
An energy gap can be opened in the spectrum of graphene reaching values as large as 0.2 eV in the case of bilayers. However, such gaps rarely lead to the highly insulating state expected at low temperatures. This long-standing puzzle is usually explained by charge inhomogeneity. Here we revisit the issue by investigating proximity-induced superconductivity in gapped graphene and comparing normal-state measurements in the Hall bar and Corbino geometries. We find that the supercurrent at the charge neutrality point in gapped graphene propagates along narrow channels near the edges...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28211342/key-issues-in-hymenoptera-venom-allergy-an-update
#12
REVIEW
T Alfaya Arias, V Soriano Gómis, T Soto Mera, A Vega Castro, J M Vega Gutiérrez, A Alonso Llamazares, D Antolín Amérigo, F J Carballada Gonzalez, C Dominguez Noche, D Gutierrez Fernandez, L Marques Amat, A Martinez Arcediano, M Martinez San Ireneo, A Moreno Ancillo, Y Puente Crespo, B Ruiz Leon, L Sánchez Morillas
In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211106/a-pilot-randomised-controlled-trial-investigating-a-mediterranean-diet-intervention-in-pregnant-women-for-the-primary-prevention-of-allergic-diseases-in-infants
#13
D A Sewell, V S Hammersley, A Robertson, G Devereux, A Stoddart, C J Weir, A Worth, A Sheikh
BACKGROUND: Observational studies suggest a potentially protective role of the Mediterranean diet (MD) in allergic diseases, including asthma. Large scale randomised controlled trials (RCTs) are needed to test the hypothesised allergy-prevention benefits of a MD during pregnancy. The present two-arm pilot RCT in pregnant women at high-risk of having a child who would develop allergic disease investigated maternal recruitment, retention and acceptability of an MD dietary intervention in the UK...
February 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28209971/obesity-paradox-in-group-1-pulmonary-hypertension-analysis-of-the-nih-pulmonary-hypertension-registry
#14
S Mazimba, E Holland, V Nagarajan, A D Mihalek, J L W Kennedy, K C Bilchick
BACKGROUND: The 'obesity paradox' refers to the fact that obese patients have better outcomes than normal weight patients. This has been observed in multiple cardiovascular conditions, but evidence for obesity paradox in pulmonary hypertension (PH) remains sparse. METHODS: We categorized 267 patients from the NIH PH Registry into five groups based on BMI: underweight, normal weight, overweight, obese, and morbidly obese. Mortality was compared in BMI groups using the chi square statistic...
February 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28209224/systematic-evaluation-of-pleiotropy-identifies-6-further-loci-associated-with%C3%A2-coronary-artery%C3%A2-disease
#15
Thomas R Webb, Jeanette Erdmann, Kathleen E Stirrups, Nathan O Stitziel, Nicholas G D Masca, Henning Jansen, Stavroula Kanoni, Christopher P Nelson, Paola G Ferrario, Inke R König, John D Eicher, Andrew D Johnson, Stephen E Hamby, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Eric E Schadt, Johan L M Björkegren, Peter E Weeke, Paul L Auer, Ursula M Schick, Yingchang Lu, He Zhang, Marie-Pierre Dube, Anuj Goel, Martin Farrall, Gina M Peloso, Hong-Hee Won, Ron Do, Erik van Iperen, Jochen Kruppa, Anubha Mahajan, Robert A Scott, Christina Willenborg, Peter S Braund, Julian C van Capelleveen, Alex S F Doney, Louise A Donnelly, Rosanna Asselta, Pier A Merlini, Stefano Duga, Nicola Marziliano, Josh C Denny, Christian Shaffer, Nour Eddine El-Mokhtari, Andre Franke, Stefanie Heilmann, Christian Hengstenberg, Per Hoffmann, Oddgeir L Holmen, Kristian Hveem, Jan-Håkan Jansson, Karl-Heinz Jöckel, Thorsten Kessler, Jennifer Kriebel, Karl L Laugwitz, Eirini Marouli, Nicola Martinelli, Mark I McCarthy, Natalie R Van Zuydam, Christa Meisinger, Tõnu Esko, Evelin Mihailov, Stefan A Escher, Maris Alver, Susanne Moebus, Andrew D Morris, Jarma Virtamo, Majid Nikpay, Oliviero Olivieri, Sylvie Provost, Alaa AlQarawi, Neil R Robertson, Karen O Akinsansya, Dermot F Reilly, Thomas F Vogt, Wu Yin, Folkert W Asselbergs, Charles Kooperberg, Rebecca D Jackson, Eli Stahl, Martina Müller-Nurasyid, Konstantin Strauch, Tibor V Varga, Melanie Waldenberger, Lingyao Zeng, Rajiv Chowdhury, Veikko Salomaa, Ian Ford, J Wouter Jukema, Philippe Amouyel, Jukka Kontto, Børge G Nordestgaard, Jean Ferrières, Danish Saleheen, Naveed Sattar, Praveen Surendran, Aline Wagner, Robin Young, Joanna M M Howson, Adam S Butterworth, John Danesh, Diego Ardissino, Erwin P Bottinger, Raimund Erbel, Paul W Franks, Domenico Girelli, Alistair S Hall, G Kees Hovingh, Adnan Kastrati, Wolfgang Lieb, Thomas Meitinger, William E Kraus, Svati H Shah, Ruth McPherson, Marju Orho-Melander, Olle Melander, Andres Metspalu, Colin N A Palmer, Annette Peters, Daniel J Rader, Muredach P Reilly, Ruth J F Loos, Alex P Reiner, Dan M Roden, Jean-Claude Tardif, John R Thompson, Nicholas J Wareham, Hugh Watkins, Cristen J Willer, Nilesh J Samani, Heribert Schunkert, Panos Deloukas, Sekar Kathiresan
BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES: This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS: In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011...
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28208418/mixing-with-applications-to-inertial-confinement-fusion-implosions
#16
V Rana, H Lim, J Melvin, J Glimm, B Cheng, D H Sharp
Approximate one-dimensional (1D) as well as 2D and 3D simulations are playing an important supporting role in the design and analysis of future experiments at National Ignition Facility. This paper is mainly concerned with 1D simulations, used extensively in design and optimization. We couple a 1D buoyancy-drag mix model for the mixing zone edges with a 1D inertial confinement fusion simulation code. This analysis predicts that National Ignition Campaign (NIC) designs are located close to a performance cliff, so modeling errors, design features (fill tube and tent) and additional, unmodeled instabilities could lead to significant levels of mix...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28206993/hemodynamic-effects-of-sodium-bicarbonate-administration
#17
A C Katheria, M K Brown, K Hassan, D M Poeltler, D A Patel, V K Brown, J B Sauberan
OBJECTIVE: To describe the hemodynamic changes that occur with sodium bicarbonate (NaHCO3) administration in premature neonates. STUDY DESIGN: This retrospective study included premature neonates 23 to 31+6 weeks of gestational age who underwent continuous cardiac and cerebral monitoring as participants in prospective trials at our institution, and who received NaHCO3 infused over 30 min in the first 24 h of life. Blood pressure (BP), heart rate, cardiac output (CO), SpO2 and cerebral oximetry (StO2) were captured every 2 s...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28205739/p-25-risk-factors-for-morbidity-and-mortality-in-esophageal-atresia-type-iii-data-from-a-population-based-register
#18
R S Sfeir, B A Bonnard, R V Rousseaux, G T Gelas, M L Michaud, K H Kotobi, D S Denapoli, B A Breton, P C Piolat, L J L Lemelle, F V Fouquet, H E Habonimana, P M L Polimerol, M J L Michel, B F Becmeur, P T Petit, L F Lavrand, E F Elbaz, A H Allal, L E Lopez, M T Merrot, B P Buisson, B J Borgnon, D P Delagausie, L G Levard, P G Podevin, L H Lardy, A F Auber, B C Borderon, P C Pelatan, J O Jaby, B J Bréaud, F L Fourcade, P M Pouzac, G S Gueiss, T C Tolg, L C Laplace, L C Langlois, G F Gottrand
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205735/p-38-risk-factors-for-eosinophilic-esophagitis-in-children-with-esophageal-atresia
#19
M A Marcon, V D Scaini, C M Forster, P P L Chiu, J C Langer, S D Dell
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205702/o-03-16-29-to-16-41-long-gap-esophageal-atresia%C3%A3-a-french-national-cohort-study-from-2008-to-2010
#20
B P Parmentier, C P Piolat, C A R M E Capito, A S Schneider, F E Elbaz, R S Sfeir, A B Bonnard, F S Sauvat, P M Pierre-Yves, M P Peycelon, G A Audry, L J Joyeux, A L Laufenburger, J L Lam Thanh, F V Varlet, H L Lardy, J B Boubnova, M G Gatibelza, T P Petit, S D De Napoli, H A Allal, A M M Boyo, M P Poli Merol, J R Ricard, H K Kotobi, F A Auber
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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