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JOURNAL ARTICLE
Apurva P Deshpande, Anil V Ankola, Roopali M Sankeshwari, Mahantesh B Nagmoti, Laxmi Kabra, Atrey J Pai Khot, Ram Surath Kumar
Aim and objectives To assess oral hygiene status and salivary and microbiological parameters among 12 to 15-year-old visually impaired and normal-sighted children before and after oral health education (OHE). Methodology An interventional study was conducted among 25 visually impaired children (Group A) and 25 normal-sighted children (Group B) in the age range of 12 to 15 years. Simple random sampling was used to select the study participants. A questionnaire was designed to record socio-demographic data and the dietary habits of the children on pre-decided days...
March 2024: Curēus
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JOURNAL ARTICLE
Filippo Costa, Eline V Schaft, Geertjan Huiskamp, Erik J Aarnoutse, Maryse A Van't Klooster, Niklaus Krayenbühl, Georgia Ramantani, Maeike Zijlmans, Giacomo Indiveri, Johannes Sarnthein
Interictal Epileptiform Discharges (IED) and High Frequency Oscillations (HFO) in intraoperative electrocorticography (ECoG) may guide the surgeon by delineating the epileptogenic zone. We designed a modular spiking neural network (SNN) in a mixed-signal neuromorphic device to process the ECoG in real-time. We exploit the variability of the inhomogeneous silicon neurons to achieve efficient sparse and decorrelated temporal signal encoding. We interface the full-custom SNN device to the BCI2000 real-time framework and configure the setup to detect HFO and IED co-occurring with HFO (IED-HFO)...
April 16, 2024: Nature Communications
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JOURNAL ARTICLE
Vasista Adupa, Elizaveta Ustyantseva, Harm H Kampinga, Patrick R Onck
DNAJB6b is a molecular chaperone of the heat shock protein network, shown to play a crucial role in preventing aggregation of several disease-related intrinsically disordered proteins. Using homology modeling and microsecond-long all-atom molecular dynamics (MD) simulations, we show that monomeric DNAJB6b is a transiently interconverting protein cycling between three states: a closed state, an open state (both abundant), and a less abundant extended state. Interestingly, the reported regulatory autoinhibitory anchor between helix V in the G/F1 region and helices II/III of the J-domain, which obstructs the access of Hsp70 to the J-domain remains present in all three states...
April 16, 2024: Nature Communications
#24
JOURNAL ARTICLE
Changyuan Hu, Jiangning Song, Terry Kwok, Elizabeth V Nguyen, Xian Shen, Roger J Daly
Different molecular classifications for gastric cancer (GC) have been proposed based on multi-omics platforms with the long-term goal of improved precision treatment. However, the GC (phospho)proteome remains incompletely characterized, particularly at the level of tyrosine phosphorylation. In addition, previous multiomics-based stratification of patient cohorts has lacked identification of corresponding cell line models and comprehensive validation of broad or subgroup-selective therapeutic targets. To address these knowledge gaps, we applied a reverse approach, undertaking the most comprehensive (phospho)proteomic analysis of GC cell lines to date and cross-validating this using publicly available data...
April 16, 2024: Molecular Oncology
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JOURNAL ARTICLE
B Cakmak, S Yeral, B Ozcan, E Pariltay, S Ozgul, I Y Simsir, R A Hegele
BACKGROUND: This study aims to show the clinical and biochemical features in patients with severe hypertriglyceridemia (HTG) associated with rare variants in the apolipoprotein A-V (APOA5) gene. MATERIALS AND METHODS: Demographics, blood lipid levels, body mass index (BMI) and APOA5 mutation subtypes were collected from the endocrinology clinic registry and analyzed for a retrospective cohort study of ten patients with severe HTG and APOA5 gene variants. RESULTS: Of the 10 cases, four were female, and six were male...
October 12, 2023: Journal of Clinical Lipidology
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REVIEW
V Delforge, C Tard, J-B Davion, K Dujardin, A Wissocq, C-M Dhaenens, E Mutez, V Huin
Biallelic intronic expansions (AAGGG)exp in intron 2 of the RFC1 gene have been shown to be a common cause of late-onset ataxia. Since their first description, the phenotypes, neurological damage, and pathogenic variants associated with the RFC1 gene have been frequently updated. Here, we review the various motifs, genetic variants, and phenotypes associated with the RFC1 gene. We searched PubMed for scientific articles published between March 1st, 2019, and January 15th, 2024. The motifs and phenotypes associated with the RFC1 gene are highly heterogeneous, making molecular diagnosis and clinical screening and investigation challenging...
April 15, 2024: Revue Neurologique
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JOURNAL ARTICLE
Veronika J Wirtz, Andrew L Gray, Sangeeta Sharma, Jing Sun, Hans V Hogerzeil
No abstract text is available yet for this article.
April 16, 2024: BMJ: British Medical Journal
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JOURNAL ARTICLE
Georgie May Massen, Philip W Stone, Harley H Y Kwok, Gisli Jenkins, Richard J Allen, Louise V Wain, Iain Stewart, Jennifer Kathleen Quint
BACKGROUND AND AIMS: Hypertension is a leading risk factor for cardiovascular disease. Electronic health records (EHRs) are routinely collected throughout a person's care, recording all aspects of health status, including current and past conditions, prescriptions and test results. EHRs can be used for epidemiological research. However, there are nuances in the way conditions are recorded using clinical coding; it is important to understand the methods which have been applied to define exposures, covariates and outcomes to enable interpretation of study findings...
April 15, 2024: Open Heart
#29
JOURNAL ARTICLE
Sergio Miras-Moreno, Óscar López-Belmonte, Amador García-Ramos, Raúl Arellano, Jesús J Ruiz-Navarro
PURPOSE: To explore the association of the load-velocity (L-V) relationship variables and ability to maintain maximal mechanical performance during the prone bench-pull exercise with sprint swimming performance and in-water forces. METHODS: Eleven competitive adult male swimmers (50-m front crawl World Aquatics points: 488 [66], performance level 4) performed 1 experimental session. The L-V relationship variables (L0 [ie, maximal theoretical load at 0 velocity]; v0 [ie, maximal theoretical velocity at 0 load], and Aline [ie, area under the L-V relationship]) and maximal mechanical maintenance capacity were assessed at the beginning of the session...
April 16, 2024: International Journal of Sports Physiology and Performance
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JOURNAL ARTICLE
Agnieszka Bodzioch, Emilia Obijalska, Rafał Jakubowski, Małgorzata Celeda, Anita Gardias, Damian Trzybiński, Paweł Tokarz, Jacek Szczytko, Krzysztof Woźniak, Piotr Kaszyński
Four isomeric di-6-oxoverdazyl diradicals connected at their N(1) or C(3) positions with either 1,3- or 1,4-phenylene linkers were obtained and characterized by spectroscopic, electrochemical, magnetic, and structural methods. These results were compared to those for the corresponding 6-oxoverdazyl monoradicals. UV-vis spectroscopy demonstrated that only the N(1)-connected para -through-benzene diradical has a distinct spectrum with significant bathochromic and hypsochromic shifts relative to the remaining species...
April 16, 2024: Journal of Organic Chemistry
#31
JOURNAL ARTICLE
Floris V Raasveld, Wen-Chih Liu, Maximilian Mayrhofer-Schmid, Brian J Wainger, Ian L Valerio, William Renthal, Kyle R Eberlin
INTRODUCTION: The biology of symptomatic neuromas is poorly understood, particularly the factors causing pain in human neuromas. Pain presence varies among and within individuals, with some having painful and nonpainful neuromas. To bridge these knowledge gaps, our group developed a protocol for assessing neuroma pain and collecting tissue for molecular analysis. This manuscript outlines our workflow and challenges and aims to inspire other centers to share their experiences with these tissues...
April 15, 2024: Journal of Surgical Research
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JOURNAL ARTICLE
S V Bueno, R O Nielsen, P Kallestrup, K Ryom, K Morgan, P Elsborg, C B Petersen, J S Jacobsen
OBJECTIVES: The World Health Organization (WHO) highlights parous women as a key population for monitoring trends of physical activity (PA). We aimed to estimate the proportion of Danish women non-adhering to WHO PA guidelines in parous women compared with nulliparous women and to describe leisure-time PA intensity in each of these groups. STUDY DESIGN: Cross-sectional study. METHODS: This population-based study builds on a sample of 27,668 women aged 16-40 years from the Danish National Health Survey 2021...
April 15, 2024: Public Health
#33
JOURNAL ARTICLE
Laura V Ferguson, Amal El Nabbout, Shelley A Adamo
Warming winters will change patterns of behaviour in temperate and polar arthropods, but we know little about the drivers of winter activity in animals such as ticks. Any changes in behaviour are likely to arise from a combination of both abiotic (e.g. temperature) and biotic (e.g. infection) drivers, and will have important consequences for survival and species interactions. Blacklegged ticks, Ixodes scapularis, have invaded Atlantic Canada and high proportions (30-50%) are infected with the bacteria causing Lyme disease, Borrelia burgdorferi...
April 12, 2024: Journal of Thermal Biology
#34
JOURNAL ARTICLE
Syed Shariq Naeem, Pooja Gupta, Ranjit Kumar Sahoo, V L Kumar, T Velpandian, Archana Singh, Atul Batra, Raja Pramanik, Sameer Rastogi, Saumya Srivastava
INTRODUCTION: Hand foot skin reaction (HFSR) is a common dose-limiting adverse effect of multi kinase inhibitors (MKI) whose mechanism is not fully understood, and the prophylaxis is inadequate. OBJECTIVE: In this pilot study, a double-blind, randomized placebo-controlled trial was conducted to evaluate the effect of topical urea in secondary prevention of sunitinib-induced HFSR in renal cell cancer patients. METHODS: Out of 55 screened patients, 14 were randomized to receive topical urea or placebo for four weeks...
March 13, 2024: Clinical Genitourinary Cancer
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JOURNAL ARTICLE
I O Kovalenko, M I Panasiuk, N V Sosonna, V E-I Khan, M G Buzynnyi, І L Koliabina, I P Оnyshchenko
This paper analyses the formation of high Sr2+ concentration in strong alkaline (pH = 9.5-12.5) groundwater using data of the 27 years of observations around the destroyed Chernobyl NPP Unit 4. It appears that the formation of strong alkaline groundwater in different monitoring wells is consistent with the distribution of 90 Sr, pH and main ions. The reason for the increase in 90 Sr concentrations is the process of its migration from the sources of contamination - leaks of highly active water localized in certain premises inside the «Shelter » object...
April 15, 2024: Journal of Environmental Radioactivity
#36
JOURNAL ARTICLE
Hung Manh Nguyen, Uyen V T Hong, Miriam Ruocco, Emanuela Dattolo, Lázaro Marín-Guirao, Mathieu Pernice, Gabriele Procaccini
Heat-priming improves plants' tolerance to a recurring heat stress event. The underlying molecular mechanisms of heat-priming are largely unknown in seagrasses. Here, ad hoc mesocosm experiments were conducted with two Mediterranean seagrass species, Posidonia oceanica and Cymodocea nodosa. Plants were first exposed to heat-priming, followed by a heat-triggering event. A comprehensive assessment of plant stress response across different levels of biological organization was performed at the end of the triggering event...
April 7, 2024: Plant Physiology and Biochemistry: PPB
#37
JOURNAL ARTICLE
Kexin Sun, Yanyi Chen, Shijie Zheng, Wenjuan Wan, Ke Hu
BACKGROUND: Traditional Chinese medicine (TCM) is useful in disease treatment and prevention. Genipin is an active TCM compound used to treat diabetic retinopathy (DR). In this study, a network pharmacology (NP)-based approach was employed to investigate the therapeutic mechanisms underlying genipin administration in DR. METHODS: The potential targets of DR were identified using the gene expression omnibus (GEO) database. TCM database screening and NP were used to predict the potential active targets and pathways of genipin in DR...
April 7, 2024: Phytomedicine
#38
JOURNAL ARTICLE
Marco Resitano, Matteo Tucci, Alessio Mezzi, Saulius Kaciulis, Bruna Matturro, Emilio D'Ugo, Lucia Bertuccini, Stefano Fazi, Simona Rossetti, Federico Aulenta, Carolina Cruz Viggi
Addressing the simultaneous removal of multiple coexisting groundwater contaminants poses a significant challenge, primarily because of their different physicochemical properties. Indeed, different chemical compounds may necessitate establishing distinct, and sometimes conflicting, (bio)degradation and/or removal pathways. In this work, we investigated the concomitant anaerobic treatment of toluene and copper in a single-chamber bioelectrochemical cell with a potential difference of 1 V applied between the anode and the cathode...
April 13, 2024: Bioelectrochemistry
#39
JOURNAL ARTICLE
Wenjie Xie, Juntao Chen, Xiaoqian Cao, Jiannan Zhang, Juanjuan Luo, Yajun Wang
Roxithromycin (ROX), a commonly used macrolide antibiotic, is extensively employed in human medicine and livestock industries. Due to its structural stability and resistance to biological degradation, ROX persists as a resilient environmental contaminant, detectable in aquatic ecosystems and food products. However, our understanding of the potential health risks to humans from continuous ROX exposure remains limited. In this study, we used the zebrafish as a vertebrate model to explore the potential developmental toxicity of early ROX exposure, particularly focusing on its effects on locomotor functionality and CaP motoneuron development...
April 15, 2024: Ecotoxicology and Environmental Safety
#40
JOURNAL ARTICLE
Tijs J Hoogteijling, Mohammad Abu Hilal, Giuseppe Zimmitti, Davit L Aghayan, Andrew G R Wu, Federica Cipriani, Salvatore Gruttadauria, Olivier Scatton, Tran Cong Duy Long, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Alejandro Mejia, James O Park, Fernando Rotellar, Gi Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P Sutcliffe, Johann Pratschke, Chung-Ngai Tang, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I Troisi, Ho Seong Han, Tan To Cheung, Atsushi Sugioka, Safi Dokmak, Kuo Hsin Chen, Rong Liu, David Fuks, Wanguang Zhang, Luca Aldrighetti, Bjørn Edwin, Brian K P Goh
BACKGROUND: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone...
April 2, 2024: European Journal of Surgical Oncology
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