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https://www.readbyqxmd.com/read/29684535/sodium-caprate-enables-the-blood-pressure-lowering-effect-of-ile-pro-pro-and-leu-lys-pro-in-spontaneously-hypertensive-rats-by-indirectly-overcoming-pept1-inhibition
#1
John P Gleeson, Jesús M Frías, Sinéad M Ryan, David J Brayden
The tripeptides, Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP), inhibit angiotensin-converting enzyme (ACE) resulting in lowered blood pressure. Our hypothesis was that the medium chain fatty acid permeation enhancer, sodium caprate (C10 ), may prevent the decrease in permeability of the tripeptides when PepT1 is inhibited by glycyl-sarcosine (Gly-Sar), a situation that may occur in the presence of food hydrolysates. Using Caco-2 monolayers and isolated rat jejunal tissue, the apparent permeability coefficients (Papp ) of [3 H]-IPP and [3 H]-LKP were assessed in the presence of Gly-Sar with and without C10 ...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29684521/the-hypoxic-peri-arteriolar-glioma-stem-cell-niche-an-integrated-concept-of-five-types-of-niches-in-human-glioblastoma
#2
REVIEW
Diana A Aderetti, Vashendriya V V Hira, Remco J Molenaar, Cornelis J F van Noorden
Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblastoma tumor samples. However, other studies have described peri-vascular niches, peri-hypoxic niches, peri-immune niches and extracellular matrix niches of GSCs...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684487/isolation-and-sequence-characterization-of-dna-a-genome-of-a-new-begomovirus-strain-associated-with-severe-leaf-curling-symptoms-of-jatropha-curcas-l
#3
Sushma Chauhan, Hifzur Rahman, Shaik G Mastan, Pamidimarri D V N Sudheer, Muppala P Reddy
Begomoviruses belong to the family Geminiviridae are associated with several disease symptoms, such as mosaic and leaf curling in Jatropha curcas. The molecular characterization of these viral strains will help in developing management strategies to control the disease. In this study, J. curcas that was infected with begomovirus and showed acute leaf curling symptoms were identified. DNA-A segment from pathogenic viral strain was isolated and sequenced. The sequenced genome was assembled and characterized in detail...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#4
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684084/local-and-systemic-inflammatory-lipid-profiling-in-a-rat-model-of-osteoarthritis-with-metabolic-dysregulation
#5
H M de Visser, S C Mastbergen, S Ravipati, P M J Welsing, F C Pinto, F P J G Lafeber, V Chapman, D A Barrett, H Weinans
OBJECTIVE: Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally induced osteoarthritis to investigate the potential role of oxylipins as a marker in the disease process of early osteoarthritis. DESIGN: Forty rats were randomly allocated to a standard or high-fat diet group...
2018: PloS One
https://www.readbyqxmd.com/read/29683914/different-patterns-in-muscular-strength-and-hypertrophy-adaptations-in-untrained-individuals-undergoing-nonperiodized-and-periodized-strength-regimens
#6
Eduardo O De Souza, Valmor Tricoli, Jacob Rauch, Michael R Alvarez, Gilberto Laurentino, André Y Aihara, Fabiano N Cardoso, Hamilton Roschel, Carlos Ugrinowitsch
De Souza, EO, Tricoli, V, Rauch, J, Alvarez, MR, Laurentino, G, Aihara, AY, Cardoso, FN, Roschel, H, and Ugrinowitsch, C. Different patterns in muscular strength and hypertrophy adaptations in untrained individuals undergoing non-periodized and periodized strength regimens. J Strength Cond Res 32(5): 1238-1244, 2018-This study investigated the effects of nonperiodized (NP), traditional periodization (TP), and daily undulating periodization (UP) regimens on muscle strength and hypertrophy in untrained individuals...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29683913/acute-cardiometabolic-responses-to-a-novel-training-rope-protocol-in-children
#7
Avery D Faigenbaum, Jie Kang, Nicholas A Ratamess, Anne Farrell, Stephanie Golda, Andrew Stranieri, Jordan Coe, Jill A Bush
Faigenbaum, AD, Kang, J, Ratamess, NA, Farrell, A, Golda, S, Stranieri, A, Coe, J, and Bush, JA. Acute cardiometabolic responses to a novel training rope protocol in children. J Strength Cond Res 32(5): 1197-1206, 2018-The purpose of this study was to quantify the acute cardiometabolic responses to a novel training rope (TR) protocol in children. Fifteen boys (10.6 ± 1.4 years) were tested for peak oxygen uptake (V[Combining Dot Above]O2) on a treadmill and subsequently (2-7 days later) performed a progressive 10-minute protocol of 5 TR exercises (EX): EX1: standing side-to-side waves, EX2: seated alternating waves, EX3: standing alternating waves, EX4: jumping jacks, and EX5: double-arm slams...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29683885/sentiment-analysis-of-web-sites-related-to-vaginal-mesh-use-in-pelvic-reconstructive-surgery
#8
Deslyn T G Hobson, Kate V Meriwether, Sean L Francis, Casey L Kinman, J Ryan Stewart
OBJECTIVES: The purpose of this study was to utilize sentiment analysis to describe online opinions toward vaginal mesh. We hypothesized that sentiment in legal Web sites would be more negative than that in medical and reference Web sites. METHODS: We generated a list of relevant key words related to vaginal mesh and searched Web sites using the Google search engine. Each unique uniform resource locator (URL) was sorted into 1 of 6 categories: "medical", "legal", "news/media", "patient generated", "reference", or "unrelated"...
April 20, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29683884/visit-to-visit-blood-pressure-variation-is-associated-with-outcomes-in-a-u-shaped-fashion-in-patients-with-myocardial-infarction-complicated-with-systolic-dysfunction-and-or-heart-failure-findings-from-the-ephesus-and-optimaal-trials
#9
João Pedro Ferreira, Kévin Duarte, Bertram Pitt, Kenneth Dickstein, John J V McMurray, Faiez Zannad, Patrick Rossignol
BACKGROUND: Visit-to-visit office blood pressure variation (BPV) has prognostic implications independent from mean BP across several populations in the cardiovascular field. The association of BPV with outcomes in patients with myocardial infarction (MI) with systolic dysfunction and/or heart failure is yet to be determined. METHODS: Two independent cohorts were assessed: the EPHESUS and the OPTIMAAL trials with a total of more than 12 000 patients. The primary outcome was all-cause death...
April 21, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29683855/a-week-48-randomized-phase-3-trial-of-darunavir-cobicistat-emtricitabine-tenofovir-alafenamide-in-treatment-na%C3%A3-ve-hiv-1-patients
#10
Joseph J Eron, Chloe Orkin, Joel Gallant, Jean-Michel Molina, Eugenia Negredo, Andrea Antinori, Anthony Mills, Jacques Reynes, Erika Van Landuyt, Erkki Lathouwers, Veerle Hufkens, John Jezorwski, Simon Vanveggel, Magda Opsomer
OBJECTIVES: To investigate efficacy and safety of a single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg vs. darunavir/cobicistat plus emtricitabine/tenofovir disoproxyl fumarate (TDF) (control) in antiretroviral-treatment-naïve, HIV-1-infected adults. DESIGN: Phase-3, randomized, active-controlled, double-blind, international, multicenter, noninferiority study (NCT02431247). METHODS: Seven hundred and twenty-five participants were randomized (1 : 1) to D/C/F/TAF (362) or control (363)...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683762/regulation-of-hemolysin-in-uropathogenic-escherichia-coli-fine-tunes-killing-of-human-macrophages
#11
Ambika M V Murthy, Minh-Duy Phan, Kate M Peters, Nguyen Thi Khanh Nhu, Rodney A Welch, Glen C Ulett, Mark A Schembri, Matthew J Sweet
Uropathogenic E. coli (UPEC) causes the majority of urinary tract infections (UTIs), which are a major global public health concern. UPEC uses numerous mechanisms to subvert the innate immune system, including targeting macrophage functions. We recently showed that some UPEC strains rapidly kill human macrophages via an NLRP3-independent pathway, and also trigger NLRP3-dependent IL-1β processing. In this study, we used random transposon mutagenesis in the reference strain CFT073 to identify UPEC genes that mediate human macrophage cell death...
April 23, 2018: Virulence
https://www.readbyqxmd.com/read/29683708/associations-or-repetitions-testing-the-basis-of-the-perruchet-effect-in-voluntary-response-speed
#12
V Annabelle Lee Cheong Lem, Caroline Moul, Justin A Harris, Evan J Livesey
The Perruchet effect refers to a dissociation between the conscious expectancy of an outcome and the strength or speed of responding in anticipation of that outcome. This dissociation is considered by some to be the best evidence for multiple learning processes with expectancy governed by participants' explicit beliefs and responding driven by the associative history of the cues that partially predict the outcome. However, an alternative nonassociative explanation is that the trends in responding are the result of recent experience with the same outcome (i...
April 23, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29683555/clinical-obesity-services-in-public-hospitals-in-australia-a-position-statement-based-on-expert-consensus
#13
E Atlantis, N Kormas, K Samaras, P Fahey, P Sumithran, S Glastras, G Wittert, K Fusco, R Bishay, T Markovic, L Ding, K Williams, I Caterson, V Chikani, P Dugdale, J Dixon
We aimed to describe the current state of specialist obesity services for adults with clinically severe obesity in public hospitals in Australia, and to analyse the gap in resources based on expert consensus. We conducted two surveys to collect information about current and required specialist obesity services and resources using open-ended questionnaires. Organizational level data were sought from clinician expert representatives of specialist obesity services across Australia in 2017. Fifteen of 16 representatives of current services in New South Wales (n = 8), Queensland (n = 1), Victoria (n = 2), South Australia (n = 3), and the Australian Capital Territory (n = 1) provided data...
April 23, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29683547/relationship-between-the-flavonoid-composition-and-flower-color-variation-in-victoria
#14
Qian Wu, Peng-Cheng Li, Hui-Jin Zhang, Cheng-Yong Feng, Shan-Shan Li, Dan-Dan Yin, Jie Tian, Wen-Zhong Xu, Liang-Sheng Wang
Victoria (Nymphaeaceae), an annual or perennial aquatic plant genus, contains only two species: V. amazonica (Poepp.) J. C. Sowerby and V. cruziana A. D. Orb. Both species exhibit large floating leaves and variable flower color. Both Victoria are night bloomers, which have white petals on the first blooming night, which then turn pink or ruby red on the second blooming day. The mechanism of the color change of Victoria petals during anthesis is still unclear. In this study, flavonoids in Victoria petals of both species were evaluated and quantified by high-performance liquid chromatography with photodiode array detection (HPLC-DAD) and by ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) for the first time...
April 23, 2018: Plant Biology
https://www.readbyqxmd.com/read/29683356/is-current-smoking-status-and-its-relationship-to-anti-cyclic-citrullinated-peptide-antibodies-a-predictor-of-worse-response-to-biological-therapies-in-rheumatoid-arthritis-patients
#15
V Torrente-Segarra, S A Bergstra, K Salomon-Escoto, Jap Da Silva, D J Veale, S Al-Emadi, Twj Huizinga
OBJECTIVE: To assess the association between smoking, anti-cyclic citrullinated peptide (anti-CCP) antibody status, and clinical efficacy of biological therapies in rheumatoid arthritis (RA) patients. METHOD: This retrospective clinical practice setting study included 1349 RA patients from the METEOR database (aged >18 years). We collected data on sociodemographics, smoking status (smoker, <10, 10-19, and >20 cigarettes/day; ex-smoker; non-smoker), baseline disease activity parameters and anti-CCP, previous disease-modifying anti-rheumatic drugs (DMARDs), biological therapy, combined therapy (steroids and DMARDs), and follow-up disease activity...
April 23, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29683252/decreasing-rates-of-acute-myocardial-infarction-in-people-living-with-hiv-a-nationwide-cohort-study-in-spain-2004-2015
#16
M Masiá, S Padilla, J A García, J I Bernardino, A A Campins, V Asensi, F Gutiérrez
OBJECTIVES: Contemporary data from country-wide cohorts are needed to reveal trends in the occurrence of acute myocardial infarction (AMI) in people living with HIV (PLWH). We analysed time trends in the standardized incidence rate (sIR) of AMI in PLWH in Spain from 2004 to 2015, and compared them with trends in the general population. METHODS: A longitudinal study in a nationwide contemporary multicentre HIV-infected cohort was carried out. Data on all incident AMI events were collected, and age- and sex-standardized IRs calculated...
April 23, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29683231/association-between-information-provision-and-supportive-care-needs-among-ovarian-cancer-survivors-a-cross-sectional-study-from-the-profiles-registry
#17
Mark J A Rietveld, Olga Husson, M C Caroline Vos, Lonneke V van de Poll-Franse, P B Nelleke Ottevanger, Nicole P M Ezendam
OBJECTIVE: To examine the association between satisfaction with perceived information provision during diagnosis and treatment and supportive care needs in ovarian cancer survivors. METHODS: In 2012, women (n=348) diagnosed with ovarian cancer, as registered between 2000 and 2010 in the Netherlands Cancer Registry, received a questionnaire including questions on the perceived level of, and satisfaction with, information received (EORTC QLQ-INFO25) and supportive care needs (Cancer Survivors' Unmet Needs Measure)...
April 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29683186/morbidity-and-mortality-according-to-age-following-gastrectomy-for-gastric-cancer
#18
S D Nelen, K Bosscha, V E P P Lemmens, H H Hartgrink, R H A Verhoeven, J H W de Wilt
BACKGROUND: This study investigated age-related differences in surgically treated patients with gastric cancer, and aimed to identify factors associated with outcome. METHODS: Data from the Dutch Upper Gastrointestinal Cancer Audit were used. All patients with non-cardia gastric cancer registered between 2011 and 2015 who underwent surgery were selected. Patients were analysed by age group (less than 70 years versus 70 years or more). Multivariable logistic regression was used to assess the influence of clinicopathological factors on morbidity and mortality...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29683026/exercise-induced-neuroplasticity-a-mechanistic-model-and-prospects-for-promoting-plasticity
#19
Jenin El-Sayes, Diana Harasym, Claudia V Turco, Mitchell B Locke, Aimee J Nelson
Aerobic exercise improves cognitive and motor function by inducing neural changes detected using molecular, cellular, and systems level neuroscience techniques. This review unifies the knowledge gained across various neuroscience techniques to provide a comprehensive profile of the neural mechanisms that mediate exercise-induced neuroplasticity. Using a model of exercise-induced neuroplasticity, this review emphasizes the sequence of neural events that accompany exercise, and ultimately promote changes in human performance...
April 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29682728/clinical-effects-of-antiplatelet-drugs-and-statins-on-d-dimer-levels
#20
Suzanne Schol-Gelok, Tom van der Hulle, Joseph S Biedermann, Teun van Gelder, Frederikus A Klok, Liselotte M van der Pol, Jorie Versmissen, Menno V Huisman, Marieke J H A Kruip
BACKGROUND: Acute pulmonary embolism may be ruled out by combining non-high clinical probability and a normal D-dimer level. Both antiplatelet drugs and HMG-CoA reductase inhibitors (statins) have been associated with effects on thrombus formation, potentially influencing D-dimer levels in this setting, leading to a higher rate of false-negative tests. Therefore we determined whether D-dimer levels in patients with suspected pulmonary embolism are affected by concomitant use of antiplatelet drugs and/or statins and evaluated if the effect of antiplatelet drugs or statins might affect diagnostic accuracy...
April 22, 2018: European Journal of Clinical Investigation
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