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https://www.readbyqxmd.com/read/29244967/diagnosis-and-treatment-of-chronic-wounds-current-standards-of-germany-s-initiative-for-chronic-wounds-e-v
#1
J Dissemond, A Bültemann, V Gerber, B Jäger, K Kröger, C Münter
The diagnosis and treatment of patients with chronic wounds is an enormous challenge in various disciplines of medicine. These very complex processes usually involve several experts of different medical specialties with varying educational backgrounds. A necessary basis for consistent communication and documentation is the use of unambiguous nomenclature. Therefore, the board of the German wound association, Initiative for Chronic Wounds (ICW) e.V., has started to define various terms and procedures. An easy to remember algorithm, in the form of the ABCDE rule, has been developed for the structured diagnosis of chronic wounds...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244957/hypercementosis-associated-with-enpp1-mutations-and-gaci
#2
V Thumbigere-Math, A Alqadi, N I Chalmers, M B Chavez, E Y Chu, M T Collins, C R Ferreira, K FitzGerald, R I Gafni, W A Gahl, K S Hsu, M S Ramnitz, M J Somerman, S G Ziegler, B L Foster
Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic phosphate (Pi) and pyrophosphate (PPi). Three regulators that control pericellular concentrations of Pi and PPi include tissue-nonspecific alkaline phosphatase (TNAP), progressive ankylosis protein (ANK), and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). Inactivation of these factors results in mineralization disorders affecting teeth and their supporting structures. This study for the first time analyzed the effect of decreased PPi on dental development in individuals with generalized arterial calcification of infancy (GACI) due to loss-of-function mutations in the ENPP1 gene...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29244532/risk-factors-and-predictors-of-significant-chondral-surface-change-from-primary-to-revision-anterior-cruciate-ligament-reconstruction-a-moon-and-mars-cohort-study
#3
Robert A Magnussen, James R Borchers, Angela D Pedroza, Laura J Huston, Amanda K Haas, Kurt P Spindler, Rick W Wright, Christopher C Kaeding, Christina R Allen, Allen F Anderson, Daniel E Cooper, Thomas M DeBerardino, Warren R Dunn, Brett A Lantz, Barton Mann, Michael J Stuart, John P Albright, Annunziato Amendola, Jack T Andrish, Christopher C Annunziata, Robert A Arciero, Bernard R Bach, Champ L Baker, Arthur R Bartolozzi, Keith M Baumgarten, Jeffery R Bechler, Jeffrey H Berg, Geoffrey A Bernas, Stephen F Brockmeier, Robert H Brophy, Charles A Bush-Joseph, J Brad Butler, John D Campbell, James L Carey, James E Carpenter, Brian J Cole, Jonathan M Cooper, Charles L Cox, R Alexander Creighton, Diane L Dahm, Tal S David, David C Flanigan, Robert W Frederick, Theodore J Ganley, Elizabeth A Garofoli, Charles J Gatt, Steven R Gecha, James Robert Giffin, Sharon L Hame, Jo A Hannafin, Christopher D Harner, Norman Lindsay Harris, Keith S Hechtman, Elliott B Hershman, Rudolf G Hoellrich, Timothy M Hosea, David C Johnson, Timothy S Johnson, Morgan H Jones, Ganesh V Kamath, Thomas E Klootwyk, Bruce A Levy, C Benjamin Ma, G Peter Maiers, Robert G Marx, Matthew J Matava, Gregory M Mathien, David R McAllister, Eric C McCarty, Robert G McCormack, Bruce S Miller, Carl W Nissen, Daniel F O'Neill, Brett D Owens, Richard D Parker, Mark L Purnell, Arun J Ramappa, Michael A Rauh, Arthur C Rettig, Jon K Sekiya, Kevin G Shea, Orrin H Sherman, James R Slauterbeck, Matthew V Smith, Jeffrey T Spang, Steven J Svoboda, Timothy N Taft, Joachim J Tenuta, Edwin M Tingstad, Armando F Vidal, Darius G Viskontas, Richard A White, James S Williams, Michelle L Wolcott, Brian R Wolf, James J York
BACKGROUND: Articular cartilage health is an important issue following anterior cruciate ligament (ACL) injury and primary ACL reconstruction. Factors present at the time of primary ACL reconstruction may influence the subsequent progression of articular cartilage damage. HYPOTHESIS: Larger meniscus resection at primary ACL reconstruction, increased patient age, and increased body mass index (BMI) are associated with increased odds of worsened articular cartilage damage at the time of revision ACL reconstruction...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29244528/phase-iii-randomized-study-of-dual-human-epidermal-growth-factor-receptor-2-her2-blockade-with-lapatinib-plus-trastuzumab-in-combination-with-an-aromatase-inhibitor-in-postmenopausal-women-with-her2-positive-hormone-receptor-positive-metastatic-breast-cancer
#4
Stephen R D Johnston, Roberto Hegg, Seock-Ah Im, In Hae Park, Olga Burdaeva, Galina Kurteva, Michael F Press, Sergei Tjulandin, Hiroji Iwata, Sergio D Simon, Sarah Kenny, Severine Sarp, Miguel A Izquierdo, Lisa S Williams, William J Gradishar
Purpose Human epidermal growth factor receptor 2 (HER2) targeting plus endocrine therapy (ET) improved clinical benefit in HER2-positive, hormone receptor (HR)-positive metastatic breast cancer (MBC) versus ET alone. Dual HER2 blockade enhances clinical benefit versus single HER2 blockade. The ALTERNATIVE study evaluated the efficacy and safety of dual HER2 blockade plus aromatase inhibitor (AI) in postmenopausal women with HER2-positive/HR-positive MBC who received prior ET and prior neo(adjuvant)/first-line trastuzumab (TRAS) plus chemotherapy...
December 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29244521/reply-to-oct-a-valuable-novel-tool-for-assessing-the-alveolar-compartment-in-ild
#5
Lida P Hariri, David C Adams, John C Wain, Michael Lanuti, Ashok Muniappan, Amita Sharma, Thomas V Colby, Mari Mino-Kenudson, Eugene J Mark, Richard L Kradin, Hannah Goulart, Melissa J Suter
No abstract text is available yet for this article.
December 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29244072/impact-of-prediagnostic-smoking-and-smoking-cessation-on-colorectal-cancer-prognosis-a-meta-analysis-of-individual-patient-data-from-cohorts-within-the-chances-consortium
#6
J M Ordóñez-Me, V Walter, B Schöttker, M Jenab, M G O'Doherty, F Kee, B Bueno-de-Mesquita, P H M Peeters, B H Stricker, R Ruiter, A Hofman, S Söderberg, P Jousilahti, K Kuulasmaa, N D Freedman, T Wilsgaard, A Wolk, L M Nilsson, A Tjønneland, J R Quirós, F J B van Duijnhoven, P D Siersema, P Boffetta, A Trichopoulou, H Brenner
Background: Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies and might also be associated with prognosis after CRC diagnosis. However, current evidence on smoking in association with CRC prognosis is limited. Patients and methods: For this individual patient data meta-analysis, sociodemographic and smoking behavior information of 12,414 incident CRC patients (median age at diagnosis: 64.3 years), recruited within 14 prospective cohort studies among previously cancer-free adults, was collected at baseline and harmonized across studies...
December 13, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29244071/the-glycosyltransferase-eogt-regulates-adropin-expression-in-decidualizing-human-endometrium
#7
Joanne Muter, Mohammad T Alam, Pavle Vrljicak, Flavio S V Barros, Peter T Ruane, Lauren J Ewington, John D Aplin, Melissa Westwood, Jan J Brosens
In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity of the feto-maternal interface and, by extension, survival of the conceptus. O-GlcNAcylation is an essential post-translational modification that links glucose sensing to cellular stress resistance. Unexpectedly, decidualization of primary endometrial stromal cells (EnSCs) was associated with a 60% reduction in O-GlcNAc modified proteins, reflecting downregulation of the enzyme that adds O-GlcNAc to substrates (O-GlcNAc transferase, OGT) but not the enzyme that removes the modification (O-GlcNAcase, OGA)...
December 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29244066/electrocardiographic-and-electrophysiologic-differentiation-between-atriofascicular-long-atrioventricular-and-short-atrioventricular-decrementally-conducting-accessory-pathways
#8
Jian-Du Yang, Gong-Bu Zhou, Qi Sun, Xiao-Gang Guo, Xu Liu, Bin Luo, Hui-Qiang Wei, Jackson J Liang, Shuanglun Xie, Fei-Fan Ouyang, Jian Ma
Aims: We aimed to examine the electrocardiographic and electrophysiologic characteristics of anterograde-conducting decremental accessory pathways (DAP) and to identify surrogate criteria to distinguish short atrioventricular (SAV) DAP from atriofascicular (AF) AP and long atrioventricular (LAV) DAP. Methods and results: We identified all patients with DAPs and analysed electrocardiographic and electrophysiologic characteristics. Distal insertion sites were examined using existing criteria, including V-H interval, ventricular activation at the right ventricular apex, and around tricuspid annulus during antidromic atrioventricular re-entrant tachycardia (A-AVRT) or complete pre-excitation and evaluated the AV node-like properties according to the response to adenosine and radiofrequency ablation...
December 13, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29243972/endoscopic-third-ventriculostomy-and-choroid-plexus-cauterization-in-infant-hydrocephalus-a-prospective-study-by-the-hydrocephalus-clinical-research-network
#9
Abhaya V Kulkarni, Jay Riva-Cambrin, Curtis J Rozzelle, Robert P Naftel, Jessica S Alvey, Ron W Reeder, Richard Holubkov, Samuel R Browd, D Douglas Cochrane, David D Limbrick, Tamara D Simon, Mandeep Tamber, John C Wellons, William E Whitehead, John R W Kestle
OBJECTIVE High-quality data comparing endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) to shunt and ETV alone in North America are greatly lacking. To address this, the Hydrocephalus Clinical Research Network (HCRN) conducted a prospective study of ETV+CPC in infants. Here, these prospective data are presented and compared to prospectively collected data from a historical cohort of infants treated with shunt or ETV alone. METHODS From June 2014 to September 2015, infants (corrected age ≤ 24 months) requiring treatment for hydrocephalus with anatomy suitable for ETV+CPC were entered into a prospective study at 9 HCRN centers...
December 15, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29243800/vesicoureteral-reflux-in-infants-what-do-we-know-about-the-gender-prevalence-by-age
#10
N Capozza, C Gulia, Z Heidari Bateni, A Zangari, S Gigli, V Briganti, S Tursini, C J Koh, M Gaffi, S Baldassarra, F Signore, A Porrello, R Piergentili
OBJECTIVE: Vesicoureteral reflux (VUR) affects up to 1% of Caucasian children. Primary VUR is characterized by failure of the ureterovesicular junction to prevent urine from traveling in a retrograde fashion from the bladder to the ureters and the kidneys. Several reports in the literature describe the prevalence of this condition in pediatric patients; overall, VUR affects more males during infancy and with higher grades. However, a thorough consideration of these articles reveals important contradictions regarding the prevalence by gender and age...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243778/apatinib-resensitizes-cisplatin-resistant-non-small-cell-lung-carcinoma-a549-cell-through-reversing-multidrug-resistance-and-suppressing-erk-signaling-pathway
#11
Z-L Liu, B-J Jin, C-G Cheng, F-X Zhang, S-W Wang, Y Wang, B Wu
OBJECTIVE: To observe the reversal effect of apatinib on the resistance to cisplatin (DDP) of A549/cisplatin (A549/DDP) cells and its relevant mechanism. MATERIALS AND METHODS: A549/DDP cells were treated with the control method, apatinib alone, DDP alone and DDP combined with apatinib. The cell proliferation was detected by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the cell clone formation assay. The cell apoptosis was detected by Hoechst 33258 staining and annexin V and propidium iodide (PI) double labeling...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243748/global-minimum-profile-error-gmpe-a-least-squares-based-approach-for-extracting-macroscopic-rate-coefficients-for-complex-gas-phase-chemical-reactions
#12
Minh V Duong, Hieu T Nguyen, Tam V-T Mai, Lam K Huynh
Master equation/Rice-Ramsperger-Kassel-Marcus (ME/RRKM) has shown to be a powerful framework for modeling kinetic and dynamic behaviors of a complex gas-phase chemical system on a complicated multiple-species and multiple-channel potential energy surface (PES) for a wide range of temperatures and pressures. Derived from the ME time-resolved species profiles, the macroscopic or phenomenological rate coefficients are essential for many reaction engineering applications including those in combustion and atmospheric chemistry...
December 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29243542/safety-assessment-of-dimethiconol-and-its-esters-and-reaction-products-as-used-in-cosmetics
#13
Wilbur Johnson, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity...
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243541/safety-assessment-of-benzyl-alcohol-benzoic-acid-and-its-salts-and-benzyl-benzoate
#14
Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
Benzyl alcohol, benzoic acid and its salts, and benzyl benzoate function mostly as fragrance ingredients/preservatives in cosmetic products. The Cosmetic Ingredient Review Expert Panel previously established concentration limits for benzyl alcohol, benzoic acid, and sodium benzoate in cosmetics and determined that the available data were insufficient to support the safety of these ingredients during inhalation exposure. After reviewing newly available data, it was concluded that benzyl alcohol, benzoic acid and its salts, and benzyl benzoate are safe in the present practices of use and concentration described in this safety assessment...
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243540/safety-assessment-of-plant-derived-fatty-acid-oils
#15
Christina L Burnett, Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 244 plant-derived fatty acid oils as used in cosmetics. Oils are used in a wide variety of cosmetic products for their skin conditioning, occlusive, emollient, and moisturizing properties. Since many of these oils are edible, and their systemic toxicity potential is low, the review focused on potential dermal effects. The Panel concluded that the 244 plant-derived fatty acid oils are safe as used in cosmetics.
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243394/the-banff-2017-kidney-meeting-report-revised-diagnostic-criteria-for-chronic-active-t-cell-mediated-rejection-antibody-mediated-rejection-and-prospects-for-integrative-endpoints-for-next-generation-clinical-trials
#16
M Haas, A Loupy, C Lefaucheur, C Roufosse, D Glotz, D Seron, B J Nankivell, P F Halloran, R B Colvin, N Alachkar, S Bagnasco, Y Bouatou, J U Becker, L Cornell, J P Duong van Huyen, I Gibson, R Mannon, M Naesens, V Nickeleit, P Nickerson, D L Segev, H K Singh, M Stegall, P Randhawa, L Racusen, K Solez, M Mengel
The kidney sessions of the 2017 Banff Conference focused on two areas: clinical implications of inflammation in areas of interstitial fibrosis and tubular atrophy (i-IFTA) and its relationship to T cell-mediated rejection (TCMR), and the continued evolution of molecular diagnostics, particularly in the diagnosis of antibody-mediated rejection (ABMR). In confirmation of previous studies, it was independently demonstrated by two groups that i-IFTA is associated with reduced graft survival. Furthermore, these groups presented that i-IFTA, particularly when involving >25% of sclerotic cortex in association with tubulitis, is often a sequela of acute TCMR in association with under-immunosuppression...
December 15, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29243322/transient-myocardial-thickening-in-cats-associated-with-heart-failure
#17
J Novo Matos, N Pereira, T Glaus, L Wilkie, K Borgeat, J Loureiro, J Silva, V Law, A Kranjc, D J Connolly, V Luis Fuentes
BACKGROUND: Cats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF. OBJECTIVES: To describe the clinical characteristics of cats with transient myocardial thickening (TMT) and CHF compared with a control population of cats without resolution of HCM. ANIMALS: A total of 21 cats with TMT, 21 cats with HCM. METHODS: Retrospective study...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29243295/extended-phase-graph-formalism-for-systems-with-magnetization-transfer-and-exchange
#18
Shaihan J Malik, Rui Pedro A G Teixeira, Joseph V Hajnal
PURPOSE: An extended phase graph framework (EPG-X) for modeling systems with exchange or magnetization transfer (MT) is proposed. THEORY: EPG-X models coupled two-compartment systems by describing each compartment with separate phase graphs that exchange during evolution periods. There are two variants: EPG-X(BM) for systems governed by the Bloch-McConnell equations, and EPG-X(MT) for the pulsed MT formalism. For the MT case, the "bound" protons have no transverse components, so their phase graph consists of only longitudinal states...
December 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29243251/factors-affecting-estimates-of-size-at-age-and-growth-in-grey-triggerfish-balistes-capriscus-from-the-northern-gulf-of-mexico
#19
R J Allman, W F Patterson, C L Fioramonti, A E Pacicco
Growth zones in dorsal spines of grey triggerfish Balistes capriscus from the northern Gulf of Mexico were utilized to estimate growth and examine factors that may affect estimates of size at age. Age was estimated from dorsal-spine sections of 4687 individuals sampled from U.S. waters during 2003-2013, including both fishery-independent (n = 1312) and fishery-dependent (n = 3375) samples. Ninety-six per cent (n = 4498) of these sections were deemed suitable for ageing; average per cent error between two independent readers was 10·8%...
December 15, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29243167/psychological-distress-among-indigenous-australian-cancer-survivors
#20
Gail Garvey, J Cunningham, M Janda, V Yf He, P C Valery
PURPOSE: The purpose of this study is to identify the level of and factors associated with distress in 155 Indigenous Australian cancer survivors approximately 6 months post-diagnosis. METHODS: The distress thermometer (DT) was used to assess clinically significant distress (defined as having a DT score ≥ 4). Logistic regression was used to identify sociodemographic and clinical factors associated with clinically significant distress. RESULTS: The mean distress score was 2...
December 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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