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Overactive bladder

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https://www.readbyqxmd.com/read/28916436/treating-overactive-bladder-in-older-patients-with-a-combination-of-mirabegron-and-solifenacin-a-prespecified-analysis-from-the-beside-study
#1
William Gibson, Scott MacDiarmid, Moses Huang, Emad Siddiqui, Matthias Stölzel, Nurul Choudhury, Marcus J Drake
BACKGROUND: The BESIDE study demonstrated that combination therapy (mirabegron and solifenacin 5mg) improved overactive bladder symptoms versus solifenacin 5mg or 10mg, and was well tolerated. OBJECTIVE: To ensure efficacy and safety is maintained in older patients (>65 yr), who usually experience greater symptom severity and comorbidities, a prespecified subanalysis stratified by age group was conducted. DESIGN, SETTING, AND PARTICIPANTS: Patients remaining incontinent (≥1 episode during 3-d diary) following 4-wk single-blind daily solifenacin 5mg were randomized 1:1:1 to a daily double-blind combination (solifenacin 5mg and mirabegron 25mg, increased to 50mg at wk 4), solifenacin 5mg or 10mg for 12 wk...
September 12, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28916252/decreased-monoamine-oxidase-a-expression-and-activity-in-the-bladders-of-rats-with-partial-outlet-obstruction
#2
Mai Michishita, Kazuo Yano, Ken-Ichi Tomita, Satoru Yoshikawa, Osamu Matsuzaki, Ken-Ichi Kasahara
OBJECTIVE To investigate changes in expression and activity of monoamine oxidase A (MAO-A) in rats with partial bladder outlet obstruction (pBOO). Previous studies suggested that monoamines, such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (NA), are involved in bladder hyperactivity secondary to pBOO. However, little is known about the role of MAO-A, an enzyme oxidizing 5-HT and NA, in the pathogenesis. METHODS Female Sprague Dawley rats were subjected to sham or pBOO operations for 7 days, then their bladders were isolated...
September 12, 2017: Urology
https://www.readbyqxmd.com/read/28914707/prospective-randomized-feasibility-study-assessing-the-effect-of-cyclic-sacral-neuromodulation-on-urinary-urge-incontinence-in-women
#3
Steven Siegel, Karl Kreder, Elizabeth Takacs, Rachael McNamara, Fangyu Kan
OBJECTIVES: The aim of this prospective, randomized, multicenter, single-blind, 4 × 4 crossover study was to estimate the effect of 4 InterStim cycling settings (continuous, 16 seconds on/8 seconds off, 10 minutes on/10 minutes off, and 30 minutes on/23.5 hours off) on efficacy, Global Response Assessment, and safety. METHODS: Eligible women implanted for at least 3 months for urgency urinary incontinence (UI) were enrolled, and daily diaries were collected. General linear mixed models were used to estimate the cycling effect on efficacy...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28914701/elevated-postvoid-residual-urine-volume-identifying-risk-factors-and-predicting-resolution-in-women-with-pelvic-organ-prolapse
#4
Amanda Ulrich, Patricia Davis, Paul Tulikangas, David M OʼSullivan, Katie Propst
OBJECTIVES: This study aims to identify risk factors for elevated preoperative postvoid residual (PVR) and persistently elevated postoperative PVR and to evaluate the resolution rate of elevated PVR urine volume in patients undergoing reconstructive surgery for pelvic organ prolapse (POP). METHODS: This was a retrospective cohort study comparing 50 women with elevated preoperative PVR (≥100 mL) and 50 women with normal PVR (<100 mL). Preoperative demographic, physical examination, urodynamic data, type of surgery performed, and postoperative trial of void data were collected...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28906080/persistence-and-adherence-with-mirabegron-vs-antimuscarinics-in-overactive-bladder-retrospective-analysis-of-a-uk-general-practice-prescription-database
#5
Adrian S Wagg, Steve Foley, John Peters, Jameel Nazir, Leanne Kool-Houweling, Ludmila Scrine
INTRODUCTION AND OBJECTIVES: Persistence with antimuscarinic (AM) drugs prescribed for overactive bladder (OAB) is poor. This study aimed to compare persistence and adherence with the beta-3-adrenoceptor agonist mirabegron (MIR) vs AMs over 12 months. PATIENTS AND METHODS: This retrospective cohort analysis included patients aged ≥18 years who were prescribed MIR, or any AM. A 12-month look-back was used to assess inclusion eligibility. The primary end-point was persistence, defined as time to first discontinuation of index drug, during 1 year follow-up...
September 14, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28905796/re-the-relationship-between-anxiety-and-overactive-bladder-or-urinary-incontinence-symptoms-in-the-clinical-population
#6
Alan J Wein
No abstract text is available yet for this article.
October 2017: Journal of Urology
https://www.readbyqxmd.com/read/28905793/re-reduction-of-urgency-severity-is-the-most-important-factor-in-the-subjective-therapeutic-outcome-of-intravesical-onabotulinumtoxina-injection-for-overactive-bladder
#7
https://www.readbyqxmd.com/read/28904950/quantitative-changes-in-cerebral-perfusion-during-urinary-urgency-in-women-with-overactive-bladder
#8
Nisha G Arya, Steven J Weissbart, Sihua Xu, Rupal Bhavsar, Hengyi Rao
PURPOSE: To quantitatively measure changes in cerebral perfusion in select regions of interest in the brain during urinary urgency in women with overactive bladder (OAB) using arterial spin labeling (ASL). METHODS: Twelve women with OAB and 10 controls underwent bladder filling and rated urinary urgency (scale 0-10). ASL fMRI scans were performed (1) in the low urgency state after voiding and (2) high urgency state after drinking oral fluids. Absolute regional cerebral blood flow (rCBF) in select regions of interest was compared between the low and high urgency states...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904941/is-there-any-relationship-between-bladder-trabeculation-and-efficacy-and-safety-of-intravesical-botulinum-toxin-a-injection-in-refractory-idiopathic-overactive-bladder-women
#9
Mahtab Zargham, Shideh Abedi, Farshid Alizadeh, Mohamad Hatef Khorami, Mehrdad Mohamadi, Faranak Bahrami, Farzaneh Sharifiaghdas, Hamid Mazdak
BACKGROUND: Intradetrusor injection of botulinum toxin A (BTX-A) might serve as a minimally invasive substitute in patients with refractory idiopathic overactive bladder (RIOAB). The aim of this study was to evaluate the clinical outcomes related to two different doses of abo-BTX-A (AboBTX-A) in patients with RIOAB. MATERIALS AND METHODS: This prospective clinical trial was performed on 55 women with RIOAB. After determination of trabeculation grade, 300 (no or mild) or 500 (moderate or severe) unit of AboBTX-A (Dysport) was intravesicaly injected...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28903631/evaluation-of-overactive-bladder-and-nocturia-as-a-risk-factor-for-hip-fracture-in-climacteric-women-a-matched-pair-case-control-study
#10
Aysun Karabulut, Serap Simavlı, Ömer Demirtaş, Nusret Ök, Harun Reşit Güngör, Ali Zümrütbaş
The aim of this study was to investigate whether overactive bladder (OAB) influences hip fractures in climacteric women by comparing the frequency of OAB and nocturia symptoms in patients with hip fractures and their age-matched controls in pre-fracture period. A total of 30 climacteric patients with a history of hip fracture were compared to a control group of 51 women in terms of OAB, nocturia and nocturia-QoL. A questionnaire composed of structured questions and Turkish validated versions of the specific questionnaires for OAB, OAB-Quality of Life (OAB-q) and nocturia-QoL was directed to the two groups...
September 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28901041/safety-and-effectiveness-of-mirabegron-in-patients-with-overactive-bladder-aged-%C3%A2-75%C3%A2-years-analysis-of-a-japanese-post-marketing-study
#11
Masaki Yoshida, Yumiko Nozawa, Daisuke Kato, Hiromi Tabuchi, Kentarou Kuroishi
OBJECTIVES: A 12-week post-marketing study was conducted to provide real-world data on Japanese patients with overactive bladder (OAB) initiating treatment with mirabegron. This post-hoc analysis focused on safety and effectiveness of mirabegron in patients aged ≥75 versus <75 years. METHODS: Incidence of adverse drug reactions (ADR) was assessed following 12 weeks' mirabegron treatment. Overactive Bladder Symptom Score (OABSS) and International-Prostate Symptom Score Quality of Life (I-PSS QoL) were completed at baseline and at the end of treatment (EoT)...
September 12, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28900856/incidence-and-management-of-de-novo-lower-urinary-tract-symptoms-after-pelvic-organ-prolapse-repair
#12
REVIEW
Henry Tran, Doreen E Chung
PURPOSE OF REVIEW: Pelvic organ prolapse (POP) is a significant problem with many options for surgical correction. Following prolapse surgery, de novo lower urinary tract symptoms (LUTS) are not uncommon. We review the current literature on de novo lower urinary tract symptoms following POP repair and discuss the role of urodynamics in the evaluation of the prolapse patient. RECENT FINDINGS: Patients with occult stress urinary incontinence (SUI) appear to be at higher risk of developing de novo SUI after POP repair...
September 12, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28892597/adult-male-stress-and-urge-urinary-incontinence-a-review-of-pathophysiology-and-treatment-strategies-for-voiding-dysfunction-in-men
#13
Eric Chung, Darren J Katz, Christopher Love
BACKGROUND: Male urinary incontinence adversely affects health-related quality of life and is associated with significant psychosexual and financial burden. The two most common forms of male incontinence are stress urinary incontinence (SUI) and overactive bladder (OAB) with concomitant urge urinary incontinence (UUI). OBJECTIVE: The objectives of this article are to briefly review the current understandings of the pathophysiological mechanisms in SUI and OAB/UUI, and offer a set of practical, action-based recommendations and treatment strategies...
September 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28892272/effect-of-cerebrospinal-fluid-shunt-surgery-on-lower-urinary-tract-dysfunction-in-idiopathic-normal-pressure-hydrocephalus
#14
Seiji Aruga, Nobumasa Kuwana, Yoshiharu Shiroki, Shintaro Takahashi, Naoyuki Samejima, Akira Watanabe, Yojiro Seki, Yasuhiko Igawa, Yukio Homma
AIMS: To examine the outcomes of lower urinary tract symptoms (LUTS) and urodynamic test results after cerebrospinal fluid (CSF) shunt surgery in idiopathic normal pressure hydrocephalus (iNPH). METHODS: Records of 48 patients (33 men; 15 women), who met the definite iNPH criteria and underwent CSF shunt surgery, were retrospectively analyzed. LUTS and their impact on quality of life (QOL) were evaluated using an all-or-none questionnaire targeting four symptoms, the Overactive Bladder Symptoms Score (OABSS), and the QOL index...
September 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28892221/a-novel-leadless-miniature-implantable-tibial-nerve-neuromodulation-system-for-the-management-of-overactive-bladder-complaints
#15
John P F A Heesakkers, Guiseppe A Digesu, Jetske van Breda, Philip Van Kerrebroeck, Sohier Elneil
BACKGROUND: Overactive bladder is a chronic condition affecting lower urinary tract function that has a significant negative impact on QoL. OBJECTIVE: Evaluation of the BlueWind implantable tibial nerve system performance and safety in refractory OAB. DESIGN, SETTING, AND PARTICIPANTS INTERVENTION: A 6-month multi-center prospective intervention study. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Objective assessment was done by voiding diary parameters included voids/day, volume voided/day, urgency assessment, leaking episodes/day, pads used/day, leak severity, and clinical success defined as a ≥50% reduction in the number of leaks/day or number of voids/day or number of episodes with degree of urgency >2 or a return to <8 voids/day on a 3 Day diary...
September 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28889761/safety-issues-associated-with-using-medication-to-treat-overactive-bladder
#16
George Araklitis, Linda Cardozo
The mainstay of overactive bladder treatment is the use of anticholinergic medication with its common side effects well known. This review focused on three less well-known safety issues when treating OAB. Areas covered: Patients with increased anticholinergic load are at risk of cognitive decline, dementia or even death. The elderly are particularly at risk due to polypharmacy. Botulinum toxin carries the risk of high urinary residuals, urinary tract infection and need to self catheterise. The use of vaginal oestrogens may improve OAB symptoms, but there is concern in those with a history of breast cancer...
September 10, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28888814/primary-and-secondary-enuresis-pathophysiology-diagnosis-and-treatment
#17
REVIEW
Bernhard Haid, Serdar Tekgül
CONTEXT: Enuresis is a common and possibly underestimated condition. While 5-10% of school-aged children suffer from the condition, a lack of background knowledge may impede timely child-adapted and successful therapy. OBJECTIVE: To provide a comprehensive overview of the pathophysiology, diagnosis, and treatment of enuresis. EVIDENCE ACQUISITION: Guideline and position papers from the European Society of Pediatric Urology, the European Association of Urology, and the International Children's Continence Society were acquired...
September 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28882559/enhancement-of-s1p-induced-contractile-response-in-detrusor-smooth-muscle-of-rats-having-cystitis
#18
Irfan Anjum, Merve Denizalti, Hilmi Burak Kandilci, Nezahat Tugba Durlu-Kandilci, Inci Sahin-Erdemli
Interstitial cystitis is a chronic disease characterized by lower abdominal pain and some nonspecific symptoms including an increase in urinary frequency and urgency. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that controls smooth muscle tone via G-protein coupled receptors (S1P1-3 receptors). S1P production is known to take place both in physiological states and some pathological situations, such as in overactive bladder syndrome. The intracellular mechanism of S1P-induced contractile response was investigated in β-escin permeabilized detrusor smooth muscle of rats having cyclophosphamide-induced cystitis...
September 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28877395/optimal-lead-positioning-in-sacral-neuromodulation-which-factors-are-related-to-treatment-outcome
#19
Ranjana Jairam, Tom Marcelissen, Gommert van Koeveringe, Philip van Kerrebroeck
OBJECTIVES: Sacral neuromodulation (SNM) is a well-established treatment for overactive bladder (OAB) and non-obstructive urinary retention (NOR). During test stimulation, the lead is positioned along the third sacral nerve, which ideally results in a response in all four contact points (active electrodes). However, it is unclear whether the position of the lead (depth, angle, deflection) and the number of active electrodes is related to the outcome of SNM. METHODS: All patients who underwent test stimulation using the tined lead between January 2011 and September 2016 were included in this retrospective study...
September 6, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28871426/assessment-of-overactive-bladder-symptoms-among-women-with-successful-pessary-placement
#20
Dimitrios Zacharakis, Themos Grigoriadis, Eleni Pitsouni, Kostas Kypriotis, Nikistratos Vogiatzis, Stavros Athanasiou
INTRODUCTION AND HYPOTHESIS: The causal association between pelvic organ prolapse (POP) and overactive bladder (OAB) symptoms is supported by several theories. The aim of this study is to assess any changes in OAB symptoms among women with POP and OAB after successful pessary placement. METHODS: During the study period, all women with symptomatic POP stage II or greater and OAB symptoms were offered the solution of either a ring or a Gellhorn pessary. All patients were asked to complete a 3-day micturition/incontinence diary...
September 4, 2017: International Urogynecology Journal
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