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Overactive bladder

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https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#1
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29332567/nociceptin-orphanin-fq-peptide-nop-receptor-modulators-an-update-in-structure-activity-relationships
#2
Carlo Mustazza, Stefano Pieretti, Francesca Marzoli
Nociceptin /Orphanin FQ Peptide" receptor (NOPr) is a G-protein-coupled receptor with the nociceptin/orphanin FQ peptide (N/OFQ) as endogenous agonist. It is expressed in the nervous system as well as in some non-neural tissues. Its activation has pronociceptive effect at the supraspinal level, whereas at the spinal level it produces nociceptive effects at low doses and antinociceptive effects at higher doses. NOPr is also involved in mood and blood pressure regulation, immunoregulation, airway constriction, feeding, urination, bowel motility, learning and memory...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29331047/the-economic-burden-of-overactive-bladder-in-the-united-states-a-systematic-literature-review
#3
REVIEW
Lauren C Powell, Shelagh M Szabo, David Walker, Katherine Gooch
AIMS: Overactive bladder (OAB) affects up to 17% of the United States (US) population. This study aimed to synthesize estimates of direct and indirect costs of OAB in the US and compare costs among those with and without OAB. METHODS: A systematic review was performed using MEDLINE/PubMed and Embase, from 2003 to 2016, following PRISMA guidelines. The target population was adults with idiopathic OAB or urge urinary incontinence from the US. Data were extracted on study and patient characteristics, all-cause and OAB-specific direct costs, resource use, and indirect costs...
January 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29329897/-botulinium-toxin-and-idiopathic-overactive-bladder-multicentric-contempory-management-in-bourgogne
#4
A Schneider, B Tourlonias, L Cormier, E Mourey, N Koutlidis, E Delorme, J Pasquale, I Kermarec, A-D Foahom-Kamwa, V Bonniaud
INTRODUCTION: Since 2014, OnabotulinumtoxinA Botox® (Allergan, Inc., Irvine, USA) represents a new therapeutic option for second-line treatment of idiopathic overactive bladder. The purpose of the current study was to evaluate practices of surgeons using onabotulinium toxin (BoNTA) in this indication. MATERIAL AND METHODS: All urogynecology centers of the country were asked in order to list all patients who were treated since marketing autorisation. Patient symptoms, previous treatments, paraclinic evaluations, data of surgery and the characteristics of the follow up were collected and analyzed...
January 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29322401/is-it-possible-to-cure-the-symptoms-of-the-overactive-bladder-in-women
#5
Jan Krhut, Alois Martan, Roman Zachoval, Tomas Hanus, Lukas Horcicka, Kamil Svabík, Peter Zvara
PURPOSE: To evaluate the feasibility of discontinuing treatment with mirabegron once symptoms have subsided in patients with overactive bladder (OAB). METHODS: The present study evaluated a total of 159 female OAB patients (age 62.9 ± 12.36), each of which were prescribed 50 mg/day mirabegron (Time point 1-T1). Data obtained from voiding diaries and patient-reported outcome variables were assessed during follow-up visits at months 1, 3, 6, 12, 18 (T2), and 21 (T4)...
January 10, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29320672/position-statement-a-clinical-approach-to-the-management-of-adult-non-neurogenic-overactive-bladder
#6
Eric Chung, Dominic Lee, Johan Gani, Michael Gillman, Christopher Maher, Janelle Brennan, Lydia Johns Putra, Laura Ahmad, Lewis Lw Chan
Overactive bladder (OAB) is a highly prevalent medical condition that has an adverse impact on various health-related quality-of-life domains, including a significant psychosocial and financial burden. This position statement, formulated by members of the Urological Society of Australia and New Zealand and the UroGynaecological Society of Australasia, summarises the current recommendations for clinical diagnosis and treatment strategies in patients with non-neurogenic OAB, and guides clinicians in the decision-making process for managing the condition using evidence-based medicine...
January 15, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29319477/publicly-funded-overactive-bladder-drug-treatment-patterns-in-ontario-over-15-years-an-ecologic-study
#7
Mina Tadrous, Dean Elterman, Wayne Khuu, Muhammad M Mamdani, David N Juurlink, Tara Gomes
INTRODUCTION: Medication is an important option for patients with overactive bladder (OAB), with four different drugs approved over the last 10 years including the first non-anticholinergic treatment, mirabegron. We set out to describe the number and rate of users of medication for the management of OAB over the last 15 years among residents of Ontario, Canada covered by the public drug programs. METHODS: We conducted a population-based, repeated cross-sectional study examining quarterly publically-funded prescription claims for OAB medications from January 2000 to June 2016 in Ontario, Canada...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29315785/three-month-clinical-results-with-a-rechargeable-sacral-neuromodulation-system-for-the-treatment-of-overactive-bladder
#8
Bertil Blok, Philip Van Kerrebroeck, Stefan de Wachter, Alain Ruffion, Frank Van der Aa, Ranjana Jairam, Marie Perrouin-Verbe, Sohier Elneil
AIMS: The primary aim of the RELAX-OAB study is to confirm the safety and efficacy of the Axonics r-SNM System, a miniaturized, rechargeable SNM system. METHODS: A total of 51 OAB patients were implanted in a single-stage implant procedure. These results represent the 3-month outcomes. Subject outcomes were evaluated using 3-day bladder diaries and quality of life questionnaires. RESULTS: A total of 31 of 34 patients (91%) that responded during an initial trial period ("Test Responders") continued to benefit from therapy with the Axonics r-SNM System at 3-months, defined as symptom improvement of ≥50% reduction in urinary voids or incontinence episodes or a return to <8 voids per day...
January 5, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29315618/no-increased-risk-of-fracture-in-patients-receiving-antimuscarinics-for-overactive-bladder-syndrome-a-retrospective-cohort-study
#9
Li-Ting Kao, Chao-Yuan Huang, Herng-Ching Lin, Chi-Ming Chu
To date, the actual relationship between antimuscarinics for overactive bladder (OAB) syndrome and the subsequent risk of a fracture remains unclear. The aim of this retrospective cohort study was to demonstrate the association between antimuscarinics for OAB and fractures using a large population-based data set. Data used in this study were taken from the Taiwan Longitudinal Health Insurance Database 2005. We identified 2927 OAB patients who received antimuscarinics as the study cohort and 11 708 matched OAB patients who did not receive antimuscarinics as the comparison cohort...
January 9, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29310199/re-natural-history-of-non-neurogenic-overactive-bladder-and-urinary-incontinence-over-5-years-in-community-dwelling-older-men-the-concord-health-and-aging-in-men-project
#10
https://www.readbyqxmd.com/read/29310194/re-impact-of-childhood-and-recent-traumatic-events-on-the-clinical-presentation-of-overactive-bladder
#11
Alan J Wein
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29310152/re-adverse-events-and-treatment-discontinuations-of-antimuscarinics-for-the-treatment-of-overactive-bladder-in-older-adults-a-systematic-review-and-meta-analysis
#12
https://www.readbyqxmd.com/read/29302716/role-of-sacral-neuromodulation-in-modern-urogynaecology-practice-a-review-of-recent-literature
#13
REVIEW
Samina Tahseen
Sacral neuromodulation (SNM) offers promise in the therapy of many pelvic floor disorders. This innovative treatment has slowly gained popularity. A review of recent literature is presented in relation to its efficacy and complications in various pelvic floor conditions: overactive bladder and urge urinary incontinence, chronic urinary retention, painful bladder syndrome, pelvic pain and double incontinence. It is a minimally invasive, completely reversible safe procedure with good long-term outcomes. However, the treatment is costly, the revision rate is high and patients require life-long follow-up...
January 4, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29300292/comparison-of-3-different-teaching-methods-for-a-behavioral-therapy-program-for-female-overactive-bladder-a-randomized-controlled-trial
#14
Elif Gezginci, Emine Iyigun, Sercan Yilmaz
PURPOSE: The purpose of this study was to compare the effect of 3 instructional methods for behavioral therapy on lower urinary tract symptom (LUTS) severity and health-related quality of life (HRQOL) in women with overactive bladder. DESIGN: Single-center, parallel-group, randomized, clinical trial. SUBJECTS AND SETTING: The sample comprised 60 women diagnosed with overactive bladder. The study setting was a university-based female urology clinic in Ankara, Turkey; data were collected from November 2012 to May 2013...
January 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29300259/sleep-quality-and-daytime-sleepiness-among-women-with-urgency-predominant-urinary-incontinence
#15
William D Winkelman, Ann Warsi, Alison J Huang, Michael Schembri, Rebecca G Rogers, Holly E Richter, Deborah L Myers, Stephen R Kraus, Karen C Johnson, Rachel Hess, Thomas Gregory, Catherine S Bradley, Lily A Arya, Jeanette S Brown, Katie L Stone, Leslee L Subak
OBJECTIVE: The objective of this study was to examine the strength and direction of the association between urinary symptoms and both poor quality sleep and daytime sleepiness among women with urgency urinary incontinence. METHODS: A planned secondary analysis of baseline characteristics of participants in a multicenter, double-blinded, 12-week randomized controlled trial of pharmacologic therapy for urgency-predominant urinary incontinence in ambulatory women self-diagnosed by the 3 Incontinence Questions was performed...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29299824/the-value-of-synchro-cystourethrometry-for-evaluating-the-relationship-between-urethral-instability-and-overactive-bladder
#16
Chaoyang Hua, Yibo Wen, Yan Zhang, Quande Feng, Xiangfei He, Yunlong Li, Junwei Wu, Jinjin Feng, Stuart B Bauer, Jianguo Wen
PURPOSE: To investigate the correlation between urethral instability (URI) and overactive bladder (OAB) in children. METHODS: We retrospectively investigated 126 children with OAB and 36 children without OAB using synchro-cystourethrometry. The prevalence of detrusor overactivity (DO) and URI, and the diagnostic sensitivity of DO alone and DO combined with URI, was compared. The OAB children with URI voluntarily received transcutaneous electrical pudendal nerve stimulation with anisodamine (stimulation group, SG) or anisodamine alone (non-stimulation group, NSG)...
January 3, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29298470/translation-and-linguistic-validation-of-the-korean-version-of-the-treatment-satisfaction-visual-analogue-scale-and-the-overactive-bladder-satisfaction-with-treatment-questionnaire
#17
Ha Na Lee, Ji Yun Chae, Hyo Serk Lee, Min Soo Choo, Min Gu Park, Seo Yeon Lee, Seung-June Oh, Sung Yong Cho
PURPOSE: This study reports the development of the Korean Version of the Treatment Satisfaction Visual Analogue Scale (TS-VAS) and the Overactive Bladder Satisfaction with Treatment Questionnaire (OAB-SAT-q) based on the original versions, with subsequent linguistic validation by Korean patients with overactive bladder receiving active treatment from a physician. METHODS: Translation and linguistic validation were performed in 2016. The validation process included permission for translation, forward translation, reconciliation, backward translation, cognitive debriefing, and proofreading...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298468/radiographic-position-of-the-electrode-as-a-predictor-of-the-outcome-of-interstim-therapy
#18
Abdullah Ahmed Gahzi, Mai Ahmed Banakhar, Dean S Elterman, Magdy Hassouna
PURPOSE: Sacral neuromodulation (SNM) therapy is indicated for some refractory urological conditions. The electrode lead position in sacral x-rays during routine follow-up may predict the outcome of SNM therapy. To determine whether the radiographic position of the electrode in the sacral foramen predicted the long-term outcome of SNM therapy. METHODS: This was a retrospective study of patients who underwent InterStim SNM at Toronto Western Hospital by 2 surgeons from July 2013 to March 2014...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298467/impact-of-preoperative-patient-characteristics-and-flow-rate-on-failure-early-complications-and-voiding-dysfunction-after-a-transobturator-tape-procedure-a-multicentre-study
#19
Andrea Cocci, Giovanni E Cacciamani, Giorgio Ivan Russo, Maria Angela Cerruto, Martina Milanesi, Luis G Medina, Sebastiano Cimino, Walter Artibani, Giuseppe Morgia, Marco Carini, Vincenzo Li Marzi
PURPOSE: To evaluate the impact of preoperative patient characteristics and flow rate on failure, early postoperative complications, and voiding in patients who underwent transvaginal tension-free vaginal tape-obturator (TVT-O) treatment for uncomplicated stress urinary incontinence (SUI). METHODS: We retrospectively reviewed patients who underwent TVT-O for SUI at 3 Italian centres. The exclusion criteria were predominant voiding and storage symptoms suggestive of detrusor overactivity, the presence of grade >1 urogenital prolapse, previous pelvic radiotherapy or other clinical contraindications for surgical procedures, neurogenic bladder dysfunction, and collagen diseases...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298466/urinary-nerve-growth-factor-as-a-potential-biomarker-of-treatment-outcomes-in-overactive-bladder-patients
#20
Yoon Seok Suh, Kwang Jin Ko, Tae Heon Kim, Hyo Serk Lee, Hyun Hwan Sung, Won Jin Cho, Kyu-Sung Lee
PURPOSE: The aim of this study was to investigate urinary nerve growth factor (NGF) as a biomarker of treatment efficacy and recurrence in overactive bladder (OAB) patients. METHODS: We enrolled 189 OAB subjects who visited our outpatient clinic from February 2010 to February 2015. All subjects with OAB received antimuscarinic treatment. A 3-day voiding diary and questionnaire were collected from each patient. Urinary levels of NGF were evaluated at baseline, the beginning of antimuscarinic treatment, and the end of antimuscarinic treatment...
December 2017: International Neurourology Journal
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