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Overactive bladder

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https://www.readbyqxmd.com/read/28637031/association-between-metabolic-syndrome-and-serum-nerve-growth-factor-levels-in-women-with-overactive-bladder
#1
Hediye Dagdeviren, Huseyin Cengiz
OBJECTIVE: This study aimed to determine the association between overactive bladder (OAB), metabolic syndrome (MetS) and serum nerve growth factors (NGF). STUDY DESIGN: Serum samples from a group of 90 women that included patients with OAB (group 1), patients with both OAB and MetS (group 2) and healthy women without OAB and MetS (group 3). Each group included 30 patients. Serum levels of NGF were compared among the groups. RESULTS: When the groups were compared with respect to NGF levels, group 2 was found to have significantly higher NGF levels (p = 0...
June 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28631830/overactive-bladder-symptoms-after-midurethral-sling-surgery-in-women-risk-factors-and-management
#2
Tom Marcelissen, Philip Van Kerrebroeck
INTRODUCTION: Overactive bladder syndrome (OAB) including urgency and urgency urinary incontinence (UUI) occurs frequently after stress urinary incontinence (SUI) surgery. It is important to identify the risk factors for the occurrence of OAB symptoms in order to adequately inform the patient before surgery. Furthermore, when facing OAB after sling surgery it is crucial to know how to manage these symptoms. METHODS: We conducted a literature review in order to assess the risk factors and management of OAB symptoms after SUI surgery...
June 20, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28627109/high-power-magnetotherapy-a-new-weapon-in-urinary-incontinence
#3
Maria Vadalà, Beniamino Palmieri, Andrea Malagoli, Carmen Laurino
OBJECTIVE: Urinary incontinence (UI) is one of the most common urinary system diseases that mostly affects women but also men. We evaluated the therapeutic efficacy of functional magnetic stimulation (FMS) as potential UI treatment with improvements in the pelvic floor musculature, urodynamic tests and quality of life. METHODS: A total of 20 UI patients (10 females and 10 men, mean age 64, 14 years), including 10 with stress UI, four with urgency UI and six with mixed UI, were treated with FMS (20 min/session) twice a week for 3 weeks...
June 18, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28622875/does-the-severity-of-overactive-bladder-symptoms-correlate-with-risk-for-female-sexual-dysfunction
#4
Cássia Raquel Teatin Juliato, Iane Glauce Ribeiro Melotti, Luiz Carlos Santos Junior, Luiz Gustavo Oliveira Britto, Cássio Luiz Zanettini Riccetto
BACKGROUND: Several studies have associated overactive bladder (OAB) with female sexual dysfunction (FSD); however, there are no reports using a quantitative approach to measure OAB severity and to relate OAB to the risk of FSD. AIM: To evaluate women with OAB and to correlate the severity of their urinary symptoms with their sexual function. METHODS: This cross-sectional study included 267 women older than 18 years with untreated OAB. All subjects completed the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and the Female Sexual Function Index (FSFI)...
June 13, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28620792/evaluation-of-coital-incontinence-by-electronic-questionnaire-prevalence-associations-and-outcomes-in-women-attending-a-urogynaecology-clinic
#5
Thomas Gray, Weiguang Li, Patrick Campbell, Swati Jha, Stephen Radley
INTRODUCTION AND HYPOTHESIS: Coital incontinence is the involuntary leakage of urine during sexual intercourse and is divided into that occurring with penetration and that occurring with orgasm. Mechanisms of coital incontinence are poorly understood. The aim of this retrospective study was to measure the prevalence of coital incontinence and evaluate the association among various types of coital incontinence with stress urinary incontinence (SUI), overactive bladder (OAB) and impact on quality-of-life in women attending a urogynaecology clinic...
June 15, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28620791/a-prospective-double-blind-randomized-two-period-crossover-multicenter-study-to-evaluate-tolerability-and-patient-preference-between-mirabegron-and-tolterodine-in-patients-with-overactive-bladder-prefer-study
#6
David Staskin, Sender Herschorn, Jonathan Fialkov, Le Mai Tu, Terry Walsh, Carol R Schermer
INTRODUCTION AND HYPOTHESIS: The objective of this study was to assess the tolerability and treatment preference in patients with overactive bladder (OAB) treated with mirabegron or tolterodine. METHODS: This was a two-period, 8-week crossover, double-blind, phase IV study (PREFER; NCT02138747) in treatment-naive adults with OAB for 3 months or longer randomized to one of four treatment sequences in a 5:5:1:1 ratio (mirabegron/tolterodine, tolterodine/mirabegron, mirabegron/mirabegron, or tolterodine/tolterodine), separated by a washout period of 2 weeks...
June 15, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28618696/re-effect-of-potentially-inappropriate-use-of-antimuscarinic-medications-on-healthcare-use-and-cost-in-individuals-with-overactive-bladder
#7
Tomas L Griebling
No abstract text is available yet for this article.
July 2017: Journal of Urology
https://www.readbyqxmd.com/read/28616110/pelvic-organ-prolapse-a-primer-for-urologists
#8
REVIEW
Michel Bureau, Kevin V Carlson
Pelvic organ prolapse (POP) results from weakness or injury of the pelvic floor supports with resulting descent of one or more vaginal compartments (anterior, apical and/or posterior). Women typically become symptomatic from the bulging vaginal wall or related organ dysfunction once this descent reaches the introitus. POP is a common condition, affecting more than half of adult women. Many women presenting to an urologist for stress urinary incontinence or overactive bladder will have associated POP; therefore, it is important for urologists who treat these conditions to be familiar with its diagnosis and management...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28615976/clinical-utility-of-neurostimulation-devices-in-the-treatment-of-overactive-bladder-current-perspectives
#9
REVIEW
Dick Aw Janssen, Frank Mj Martens, Liesbeth L de Wall, Hendrikje Mk van Breda, John Pfa Heesakkers
OBJECTIVES: This review describes the evidence from established and experimental therapies that use electrical nerve stimulation to treat lower urinary tract dysfunction. METHODS: Clinical studies on established treatments such as percutaneous posterior tibial nerve stimulation (P-PTNS), transcutaneous electrical nerve stimulation (TENS), sacral nerve stimulation (SNS) and sacral anterior root stimulation (SARS) are evaluated. In addition, clinical evidence from experimental therapies such as dorsal genital nerve (DGN) stimulation, pudendal nerve stimulation, magnetic nerve stimulation and ankle implants for tibial nerve stimulation are evaluated...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28615244/stimulation-of-the-pelvic-nerve-increases-bladder-capacity-in-the-prostaglandin-e2-rat-model-of-overactive-bladder
#10
Christopher L Langdale, James A Hokanson, Arun Sridhar, Warren M Grill
Overactive bladder (OAB) syndrome is a highly prevalent condition that may lead to medical complications and decreased quality of life. Emerging therapies focusing on selective electrical stimulation of peripheral nerves associated with lower urinary tract (LUT) function may provide improved efficacy and reduced side effects compared to sacral neuromodulation for the treatment of OAB symptoms. Prior studies investigating the effects of pelvic nerve (PelN) stimulation on LUT function were focused on promoting bladder contractions, and it is unclear if selective stimulation of the PelN would be beneficial for the treatment of OAB...
June 14, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28612999/overactive-bladder-symptom-scores-responsiveness-before-and-after-anticholinergic-treatment-in-women-with-overactive-bladder-the-pilot-study
#11
Suvit Bunyavejchevin
AIM: The aims of this study were: (i) to evaluate change of Overactive Bladder Symptom Scores (OABSS) from before to after solifenacin treatment; and (ii) to evaluate correlation between change of OABSS and 3-day micturition diary, International Prostate Symptom Score (IPSS), and Patient Perception of Bladder Condition (PPBC). METHODS: Thirty-six women, aged > 18 years, diagnosed as having overactive bladder (OAB) at King Chulalongkorn Memorial Hospital, with the symptoms of urgency, frequency with or without urge incontinence for more than 3 months, and at least three episodes of urgency with or without incontinence during the last 3 days prior to the study, were recruited during January 2010-May 2011...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28610556/toileting-behaviors-and-overactive-bladder-in-patients-with-type-2-diabetes-a-cross-sectional-study-in-china
#12
Dongjuan Xu, Ran Cheng, Aixia Ma, Meng Zhao, Kefang Wang
BACKGROUND: Overactive bladder is more prevalent in patients with type 2 diabetes than in those without diabetes. Unhealthy toileting behaviors may be associated with the development and worsening of overactive bladder symptoms. However, little is known about the relationships between toileting behaviors and overactive bladder in patients with diabetes. This study aimed to identify unhealthy toileting behaviors that patients with type 2 diabetes adopted to empty their bladders and investigate the relationships between toileting behaviors and overactive bladder...
June 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28608967/urodynamic-effects-of-intravenous-and-intrathecal-administration-of-e-series-prostaglandin-1-receptor-antagonist-on-detrusor-overactivity-in-rats-with-spinal-cord-injury
#13
Naoki Wada, Katsumi Kadekawa, Tsuyoshi Majima, Takahiro Shimizu, Pradeep Tyagi, Hidehiro Kakizaki, Naoki Yoshimura
AIMS: We examined the effect of an E-series prostaglandin 1 (EP1) receptor antagonist on bladder activity using a rat model of spinal cord injury (SCI). METHODS: Female Sprague-Dawley rats were used. Six weeks after spinal cord transection, conscious-filling cystometry was performed. We evaluated the urodynamic parameters before and after intravenous (0.1 and 1.0 mg/kg) or intrathecal (0.1 and 1.0 µg) administration of SC51089, an EP1 antagonist. Spinal prostaglandin E2 (PGE2) concentration and EP1 receptor transcripts in the spinal cord and dorsal root ganglia (DRG) were measured by enzyme-linked immunosorbent assay and RT-PCR, respectively...
June 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28608746/new-insights-in-the-metabolism-of-oxybutynin-evidence-of-n-oxidation-of-propargylamine-moiety-and-rearrangement-to-enaminoketone
#14
Silvio Aprile, Rossana Canavesi, Rosanna Matucci, Cristina Bellucci, Erika Del Grosso, Giorgio Grosa
1. Oxybutynin hydrochloride is an antimuscarinic agent prescribed to patients with an overactive bladder and symptoms of urinary urge incontinence. Oxybutynin undergoes pre-systemic metabolism, and the N-desethyloxybutynin (Oxy-DE), is reported to have similar anticholinergic effects. 2. We revisited the oxidative metabolic fate of oxybutynin by liquid chromatography tandem mass spectrometry analysis of incubations with rat and human liver fractions, and by measuring plasma and urine samples collected after oral administration of oxybutynin in rats...
June 13, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28605059/amniotic-fluid-stem-cells-ameliorate-bladder-dysfunction-induced-by-chronic-bladder-ischemia-in-rat
#15
Ching-Chung Liang, Sheng-Wen Steven Shaw, Yi-Hao Lin, Tsong-Hai Lee
AIMS: This study investigated the protective effect of human amniotic fluid-derived stem cells (hAFSCs) against bladder overactivity in rat model of atherosclerosis-induced chronic bladder ischemia. METHODS: Adult female Sprague-Dawley rats were divided into six groups: (1) Normal control with a regular diet for 8 weeks, (2) Sham-operation, (3) arterial balloon endothelial injury (AEI) of common iliac artery (AEI only), and post-AEI consecutive hAFSCs treatment for (4) 1 day, (5) 3 days, and (6) 7 days...
June 12, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28605052/effects-of-pedunculopontine-nucleus-stimulation-on-human-bladder-function
#16
Holly A Roy, Debbie Pond, Christopher Roy, Beth Forrow, Thomas Foltynie, Ludvic Zrinzo, Harith Akram, Tipu Z Aziz, James J FitzGerald, Alexander L Green
AIMS: The pedunculopontine nucleus (PPN) is a deep brain stimulation target for Parkinson's disease (PD). Unilateral PPN stimulation has been described in a previous case report to provoke urinary frequency, urgency and detrusor overactivity, due to probable activation of the pontine micturition center. Our aim was to evaluate the effect of bilateral PPN DBS on urodynamic parameters and to investigate the likely mechanisms using probabilistic tractography. METHODS: Six male PD subjects with bilateral PPN deep brain stimulators were recruited...
June 12, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28598139/mini-sling-efficacy-in-obese-versus-non-obese-patients-for-treatment-of-stress-urinary-incontinence
#17
Matteo Frigerio, Cristina Regini, Stefano Manodoro, Federico Spelzini, Rodolfo Milani
BACKGROUND: The impact of obesity on single-incision has been object of concerns. The aim of the study was to compare the outcomes of MiniArc single-incision sling in normal weight, overweight and obese patients. METHODS: This retrospective study analysed women with proven stress urinary incontinence (SUI). Patients were divided into three groups according to BMI: normal weight (group A), overweight (group B) and obese (group C). Objective cure rate was assessed with stress test and subjective cure rate was determined by ICIQ-SF and PGI-I scores...
June 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28596838/botulinum-neurotoxins-serotypes-a-and-b-induce-paralysis-of-mouse-striated-and-smooth-muscles-with-different-potencies
#18
Jacquie Maignel-Ludop, Marion Huchet, Johannes Krupp
To address the scarcity of direct comparison of botulinum neurotoxin serotypes activity on smooth versus striatal muscle, we have studied the action of BoNT/A1 and BoNT/B1 on ex vivo preparations of both muscle types. We have set up and characterized a model of neurogenic contractions in the isolated mouse bladder, and used this model to explore the effects of the two serotypes on contractions evoked by electrical field stimulation. Both toxins were also tested in the mouse phrenic nerve hemidiaphragm assay, to compare their potency in smooth versus striated muscle...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28593367/vulvar-lichen-sclerosus-in-women-is-associated-with-lower-urinary-tract-symptoms
#19
Corina Christmann-Schmid, Melanie Hediger, Sabine Gröger, Jörg Krebs, Andreas R Günthert
INTRODUCTION AND HYPOTHESIS: Lichen sclerosus (LS) is thought to be primarily a disease of postmenopausal women. Little is reported about lower urinary tract symptoms (LUTS) in association with LS. The aims of this study were to evaluate the odds of having LS-associated LUTS and to identify the predominant type of LS-associated bladder dysfunction. METHODS: This was a cross-sectional study with two cohorts investigating the association between LS and LUTS and the predominant type of LS-associated bladder dysfunction...
June 7, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28593170/increased-detrusor-collagen-is-associated-with-detrusor-overactivity-and-decreased-bladder-compliance-in-men-with-benign-prostatic-obstruction
#20
Carlos H S Bellucci, Wesley de O Ribeiro, Thiago S Hemerly, José de Bessa, Alberto A Antunes, Katia R M Leite, Homero Bruschini, Miguel Srougi, Cristiano M Gomes
BACKGROUND: This study aimed to investigate the relationship between detrusor collagen content and urodynamic parameters in men with benign prostatic obstruction. MATERIAL AND METHODS: Nineteen consecutive patients undergoing open prostatectomy for bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) were evaluated. Urodynamic tests were performed in all patients. BOO and detrusor contractility were assessed with the BOO index (BOOI) and the bladder contractility index (BCI), respectively...
June 2017: Prostate International
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