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Overactive bladder

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https://www.readbyqxmd.com/read/28533105/prevalence-of-overactive-bladder-and-its-impact-on-quality-of-life-in-1025-patients-with-type-2-diabetes-in-mainland-china
#1
Dongjuan Xu, Jie Gao, Xiaojuan Wang, Liqun Huang, Kefang Wang
AIMS: This study examined the prevalence of overactive bladder (OAB) and investigated the impact of OAB on quality of life (QOL) in patients with type 2 diabetes in Mainland China. METHODS: A total of 1025 patients with type 2 diabetes were surveyed. Patients were grouped into no OAB, dry OAB, and wet OAB groups according to the presence of OAB and urge incontinence. Descriptive analyses, one-way analysis of variance (ANOVA) and multivariable regression models were conducted to assess the prevalence of OAB and the effect of OAB on QOL...
May 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28530066/-position-statement-on-overactive-bladder
#2
Ilan Grunwald, Kobi Stav, Jacob Golomb, Joseph Abarbanel, Gabriel Gillon, Alexander Greenstein
Bothersome urinary symptoms during the storage phase are common among women and men. These symptoms described as urinary urgency, frequency and nocturia with or without urge urinary incontinence may be caused by various pathologies including bladder overactivity. Diagnosis of an overactive bladder is based on the patient's clinical presentation after exclusion of other disorders that may cause these symptoms. The minimal requirements for a urological evaluation include medical history, physical examination and urinalysis...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28527720/overactive-bladder-oab-a-symptom-in-search-of-a-disease-its-relationship-to-specific-lower-urinary-tract-symptoms-and-conditions
#3
Jason P Van Batavia, Andrew J Combs, Angela M Fast, Kenneth I Glassberg
BACKGROUND: The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence. OBJECTIVE: We sought to determine how often these associated findings occur in OAB and what if any uroflow/EMG-defined conditions are found to be associated with it. METHODS: The charts of 548 children (231M, 318F; mean age 9...
March 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28515812/cost-effectiveness-of-mirabegron-compared-to-tolterodine-er-4-mg-for-overactive-bladder-in-canada
#4
Sender Herschorn, Jameel Nazir, Barbara Ramos, Zalmai Hakimi
INTRODUCTION: This analysis compared the cost-effectiveness of once-daily regimens of mirabegron 50 mg and generic tolterodine ER 4 mg in a hypothetical cohort of previously treated patients with overactive bladder (OAB) in Canada. METHODS: A Markov model was developed to represent different health states according to OAB symptoms (frequency, incontinence), presence/absence of adverse events (AEs; dry mouth, constipation, blurred vision), and treatment status (on-treatment, discontinue treatment, restart previous treatment)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28515177/do-%C3%AE-3-adrenoceptor-agonists-cause-urinary-bladder-smooth-muscle-relaxation-by-inhibiting-acetylcholine-release
#5
Katerina Okeke, Stavros Gravas, Martin C Michel
The mechanisms leading to improvement of overactive bladder syndrome upon treatment with a β3-adrenoceptor agonist remain controversial. New research points to a role of inhibition of neuronal acetylcholine release. Whether this occurs by a direct effect on prejunctional β3-adrenoceptors or indirectly by formation of adenosine and activation of A1 adenosine receptors is being discussed.
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28508889/influence-of-bladder-lithiasis-on-lower-urinary-tract-dynamics-in-patients-with-spinal-cord-injury
#6
M Vírseda-Chamorro, J Salinas-Casado, Á Barroso-Manso, P Gutiérrez-Martín, M E Fuertes
STUDY DESIGN: A prospective and a case-matched control study. OBJECTIVES: To study the lower urinary tract dysfunction associated with bladder lithiasis in patients with spinal cord injury (SCI). SETTING: Toledo (Spain). METHODS: We have carried out a urodynamic study in 30 patients with SCI with lithiasis in their bladder before and 3 months after bladder endoscopic lithotripsy. This second study was compared with the urodynamic findings of a different group of 30 patients with SCI, without a history of bladder lithiasis, paired with cases by gender and date of urodynamic study...
May 16, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28506944/effect-of-sacrocolpopexy-and-retropubic-sling-on-overactive-bladder-symptoms
#7
Muhammad Faisal Aslam, William T Gregory, Blake Osmundsen
OBJECTIVE: In this study, we aimed to evaluate the effect of sacrocolpopexy and retropubic midurethral sling, or transvaginal tape (TVT) procedure, on overactive bladder (OAB) symptoms. Our null hypothesis was that concomitant sacrocolpopexy and TVT exacerbate OAB symptoms. MATERIAL AND METHODS: This is a prospective cohort study. All subjects had apical/anterior prolapse and underwent robotic-assisted sacrocolpopexy and TVT, with or without concomitant hysterectomy...
March 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28506859/the-obstructed-bladder-expression-of-collagen-matrix-metalloproteinases-muscarinic-receptors-angiogenic-and-neurotrophic-factors-in-patients-with-benign-prostatic-hyperplasia
#8
João Arthur Brunhara Alves Barbosa, Sabrina T Reis, Marco Nunes, Yuri A Ferreira, Katia R Leite, William C Nahas, Miguel Srougi, Alberto A Antunes
OBJECTIVE: to evaluate gene expression of Collagen, Matrix Metalloproteinases (MMP) and Inhibitors, Cholinergic Muscarinic Receptors (CHRM), Angiogenic and Nerve Growth Factors (NGF) in the bladder of patients with Bladder Outlet Obstruction due to Benign Prostatic Hyperplasia METHODS: We analyzed bladder specimens from 43 patients with obstructive BPH undergoing TURP as compared to 10 age-matched controls with IPSS<8 and prostate <30g. A bladder biopsy was performed for relative gene expression analysis with qRT-PCR of Collagens I and III, MMPs 1,2,9; Tissue Inhibitors of Metalloproteinases (TIMP) 1,2 and RECK; CHRM2 and -3; VEGF, CD105; NGF and NGF receptor...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28506854/long-term-safety-and-efficacy-of-solifenacin-in-children-and-adolescents-with-overactive-bladder
#9
Donald Newgreen, Brigitte Bosman, Adriana Hollestein-Havelaar, Ellen Dahler, Robin Besuyen, Robert Snijder, Will Sawyer, Søren Rittig, Stéphane Bolduc
PURPOSE: To evaluate long-term safety and efficacy of once-daily oral solifenacin suspension in children (aged 5-<12 years) and adolescents (aged 12-<18 years) with overactive bladder. MATERIALS AND METHODS: 40-week, open-label extension of a 12-week double-blind, placebo-controlled trial. OUTCOME MEASURES: incidence and severity of adverse events (primary endpoint), laboratory variables, vital signs, 12-lead electrocardiogram, post-void residual volume, change from baseline to end of treatment in: mean number of micturitions and incontinence episodes/24 hours, number of incontinence-free days/7 days, number of grade 3 or 4 urgency episodes/24 hours (adolescents only)...
May 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28505926/re-effectiveness-of-solifenacin-and-trospium-for-managing-of-severe-symptoms-of-overactive-bladder-in-patients-with-benign-prostatic-hyperplasia
#10
https://www.readbyqxmd.com/read/28505920/re-is-self-reported-adherence-associated-with-clinical-outcomes-in-women-treated-with-anticholinergic-medication-for-overactive-bladder
#11
Alan J Wein
No abstract text is available yet for this article.
June 2017: Journal of Urology
https://www.readbyqxmd.com/read/28505918/re-electronic-bladder-diaries-of-differing-duration-versus-a-paper-diary-for%C3%A2-data-collection-in-overactive-bladder
#12
Alan J Wein
No abstract text is available yet for this article.
June 2017: Journal of Urology
https://www.readbyqxmd.com/read/28503243/appendix-executive-summary-of-cua-guideline-on-adult-overactive-bladder
#13
Jacques Corcos, Mikolaj Przydacz, Lysanne Campeau, Gary Gray, Duane Hickling, Christiane Honeine, Sidney B Radomski, Lynn Stothers, Adrian Wagg
No abstract text is available yet for this article.
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28503231/onabotulinumtoxina-for-the-treatment-of-idiopathic-overactive-bladder-is-effective-and-safe-for-repeated-use
#14
Kevin Carlson, Andrea Civitarese, Richard Baverstock
INTRODUCTION: The objective of this study was to compare efficacy and safety outcomes between patients receiving onabotulinum-toxinA (OnabotA) for the first time and those receiving a repeat injection. METHODS: Data collected before and after OnabotA injection were extracted from a clinical registry. Patients were classified into either first or repeat injection subgroups. Efficacy was measured by the change in use of oral bladder medications, the number of voids per day or night, the frequency of urinary incontinence (UI) episodes, and patient-reported outcomes...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28503229/cua-guideline-on-adult-overactive-bladder
#15
Jacques Corcos, Mikolaj Przydacz, Lysanne Campeau, Gary Gray, Duane Hickling, Christiane Honeine, Sidney B Radomski, Lynn Stothers, Adrian Wagg, Frcp Lond
No abstract text is available yet for this article.
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28502833/overactive-bladder-is-strongly-associated-with-frailty-in-older-individuals
#16
Anne M Suskind, Kathryn Quanstrom, Shoujun Zhao, Mark Bridge, Louise C Walter, John Neuhaus, Emily Finlayson
OBJECTIVES: To understand the relationship between age, frailty and overactive bladder (OAB). METHODS: This is a prospective study of individuals age ≥65 presenting to an academic urology practice between December 2015 and July 2016. All patients had a Timed Up and Go Test (TUGT), a parsimonious measure of frailty, on intake and were thereby categorized as fast (≤10 sec), intermediate (11-14 sec) and slow (≥15 sec). The TUGT and other clinical data were abstracted from the electronic medical record (EMR) using direct queries...
May 11, 2017: Urology
https://www.readbyqxmd.com/read/28501541/characteristics-associated-with-treatment-response-and-satisfaction-in-women-undergoing-onabotulinumtoxina-and-sacral-neuromodulation-for-refractory-urgency-urinary-incontinence
#17
H E Richter, C L Amundsen, S W Erickson, J E Jelovsek, Y Komesu, C Chermansky, H S Harvie, M Albo, D Myers, W T Gregory, D Wallace
PURPOSE: To identify clinical and demographic characteristics associated with treatment response and satisfaction in women undergoing onabotulinumtoxinA and sacral neuromodulation therapies. MATERIAL AND METHODS: Data were analyzed from the Refractory Overactive Bladder: Sacral Neuromodulation vs Botulinum Toxin Assessment trial. Baseline participant characteristics and clinical variables associated with two definitions of treatment response: 1) reduction in mean daily urgency incontinence episodes over 6 months 2) ≥50% decrease in urgency incontinence episodes across 6 months were identified...
May 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28493606/micrornas-as-potential-biomarkers-to-predict-the-risk-of-urinary-retention-following-intradetrusor-onabotulinumtoxin-a-injection
#18
Christopher J Chermansky, Brian T Kadow, Mahendra Kashyap, Pradeep Tyagi
AIMS: MicroRNAs (miRs) control post-transcriptional gene expression, and this is relevant in understanding better chronic diseases and treatment outcomes. The role of miRs in the pathology and treatment outcomes of overactive bladder (OAB) is unknown. In this study, we assessed the differential expression of miRs in OAB patients responding with either normal or elevated post-void residual volumes (PVRs) ≥200 mL following intradetrusor injection of onabotulinumtoxin-A (onaBoNT-A). METHODS: Female OAB patients refractory to OAB drugs were consented for this study...
May 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28490209/retrospective-analysis-in-46-women-with-vulvovaginal-atrophy-treated-with-ospemifene-for-12-weeks-improvement-in-overactive-bladder-symptoms
#19
Michele Carlo Schiavi, Marzio Angelo Zullo, Pierangelo Faiano, Ottavia D'Oria, Giovanni Prata, Vanessa Colagiovanni, Andrea Giannini, Chiara Di Tucci, Giorgia Perniola, Violante Di Donato, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici
AIMS: The aim of this study was to assess the effectiveness and safety of ospemifene in the improvement of overactive bladder (OAB) symptoms in postmenopausal women affected by vulvovaginal atrophy (VVA). METHODS: Forty-six postmenopausal patients affected by VVA with OAB syndrome were enrolled for the study. All patients received Ospemifene 60 mg for 12 weeks. Clinical examination, 3-day voiding diary, urodynamic testing, ultrasound measurement of endometrial and bladder wall thickness (BWT) and the Vaginal Health Index (VHI) were performed at baseline and 12 weeks...
May 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28489120/overactive-bladder-pharmacological-treatment
#20
José Carlos Truzzi, Antonio Silvinato, Wanderley Marques Bernardo
No abstract text is available yet for this article.
March 2017: Revista da Associação Médica Brasileira
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