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Hibernating myocardium

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https://www.readbyqxmd.com/read/29429060/electrophysiological-differences-in-cholinergic-signaling-between-the-hearts-of-summer-and-winter-frogs-rana-temporaria
#1
Denis Abramochkin, Vladislav Kuzmin
The striking seasonal difference in sensitivity of frog cardiac muscle to acetylcholine or stimulation of parasympathetic nervous fibers has been noted almost a century ago, although its electrophysiological basis has never been revealed. The present study compares the effects of the muscarinic agonist carbamylcholine chloride (CCh 10-8-10-5 M) on electrical activity in isolated atrial and ventricular preparations from dormant frogs (Rana temporaria) caught in January (winter-acclimatized, WA) and from active frogs caught in July (summer-acclimatized, SA)...
February 10, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29239459/ischemic-left-ventricle-systolic-dysfunction-an-evidence-based-approach-in-diagnostic-tools-and-therapeutics
#2
Eduardo Gomes Lima, Felipe Pereira Câmara de Carvalho, Jaime Paula Pessoa Linhares Filho, Fabio Grunspun Pitta, Carlos Vicente Serrano
Coronary artery disease (CAD) associated with left ventricular systolic dysfunction is a condition related to poor prognosis. There is a lack of robust evidence in many aspects related to this condition, from definition to treatment. Ischemic cardiomyopathy is a spectrum ranging from stunned myocardium associated with myocardial fibrosis to hibernating myocardium and repetitive episodes of ischemia. In clinical practice, relevance lies in identifying the myocardium that has the ability to recover its contractile reserve after revascularization...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29066338/electrocardiographic-changes-after-successful-recanalization-of-a-chronic-total-coronary-occlusion-a-systematic-review-and-meta-analysis
#3
REVIEW
Ivo M van Dongen, Joëlle Elias, Veronique M F Meijborg, Jacques M T De Bakker, Jacqueline Limpens, Chantal E Conrath, José P S Henriques
BACKGROUND: Observational studies suggest that in patients with a CTO successful recanalization is associated with better clinical outcome. This could be related to a reduction in the occurrence of arrhythmias, which may result from modifications of the hibernating myocardium in a CTO region. METHODS AND RESULTS: We aimed to evaluate the effect of CTO PCI on electrophysiological parameters, and conducted a systematic review and meta-analysis according to the PRISMA guidelines...
September 12, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28966019/n-terminal-pro-b-type-natriuretic-peptide-and-high-sensitivity-cardiac-troponin-t-levels-are-related-to-the-extent-of-hibernating-myocardium-in-patients-with-ischemic-heart-failure
#4
Jason G E Zelt, Peter P Liu, Fernanda Erthal, Robert A deKemp, George Wells, Eileen O'Meara, Linda Garrard, Rob S B Beanlands, Lisa M Mielniczuk
BACKGROUND: Increased N-terminal pro b-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) can identify patients with heart failure (HF) who are at increased risk of cardiac events. The relationship of these biomarkers to the extent of hibernating myocardium and scar has not been previously characterized in patients with ischemic left ventricular dysfunction and HF. METHODS: Patients with ischemic HF meeting recruitment criteria and undergoing perfusion and fluorodeoxyglucose-positron emission tomography to define myocardial hibernation and scar were included in the study...
November 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28903476/adenoviral-intramyocardial-vegf-d%C3%AE-n%C3%AE-c-gene-transfer-increases-myocardial-perfusion-reserve-in-refractory-angina-patients-a-phase-i-iia-study-with-1-year-follow-up
#5
Juha Hartikainen, Iiro Hassinen, Antti Hedman, Antti Kivelä, Antti Saraste, Juhani Knuuti, Minna Husso, Hanna Mussalo, Marja Hedman, Tuomas T Rissanen, Pyry Toivanen, Tommi Heikura, Joseph L Witztum, Sotirios Tsimikas, Seppo Ylä-Herttuala
Aims: We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-DΔNΔC gene therapy in patients with refractory angina. Methods and results: Thirty patients were randomized to AdVEGF-DΔNΔC (AdVEGF-D) or placebo (control) groups. Electromechanical NOGA mapping and radiowater PET were used to identify hibernating viable myocardium where treatment was targeted. Safety, severity of symptoms, quality of life, lipoprotein(a) [Lp(a)] and routine clinical chemistry were measured...
September 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28878945/gated-metabolic-myocardial-imaging-a-surrogate-for-dual-perfusion-metabolism-imaging-by-positron-emission-tomography
#6
Abdallah AlMohammad, Murdoch Y Norton, Andrew E Welch, Peter F Sharp, Stephen Walton
OBJECTIVE: Perfusion-metabolism mismatch pattern on positron emission tomography (PET) predicts hibernating myocardium. We assess the ECG-gated metabolic PET as a surrogate for the perfusion-metabolism mismatch pattern on PET imaging. METHODS: (13)N-Ammonia (NH3) and (18)F-fluorodeoxyglucose (FDG) are respectively perfusion and metabolism PET tracers. We used ECG gating to acquire FDG-PET to collect wall thickening (mechanical) data. These allow detection of metabolic activity in regions with reduced contraction (metabolism-mechanical mismatch pattern)...
2017: Open Heart
https://www.readbyqxmd.com/read/28867116/precision-medicine-and-pet-computed-tomography-in-cardiovascular-disorders
#7
REVIEW
Elizabeth H Dibble, Don C Yoo
PET/computed tomography (CT) can evaluate the metabolic and anatomic involvement of a variety of inflammatory, infectious, and malignant cardiovascular disorders. PET/CT is useful in evaluating coronary vasculature, hibernating myocardium, cardiac sarcoidosis, cardiac amyloidosis, cerebrovascular disease, acute aortic syndromes, cardiac and vascular neoplasms, cardiac and vascular infections, and vasculitis. Novel targeted radiopharmaceutical agents and novel use of established techniques show promise in diagnosing and monitoring cardiovascular diseases...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28833528/intraoperative-assessment-of-transient-and-persistent-regional-left-ventricular-wall-motion-abnormalities-in-patients-undergoing-coronary-revascularization-surgery-using-real-time-three-dimensional-transesophageal-echocardiography-a-prospective-observational
#8
Neelam Aggarwal, Koniparambil P Unnikrishnan, Indranil Biswas, Jayakumar Karunakaran, Puthuvasseri R Suneel
OBJECTIVE: To evaluate the feasibility of intraoperative real time three-dimensional echocardiography (RT3DE) for identification and quantification of transient and persistent regional wall motion abnormalities (RWMAs) in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (CABG). DESIGN: A prospective observational study SETTING: Single-center study in an academic tertiary care hospital PARTICIPANTS: A series of 42 patients undergoing elective CABG over a 2-year period were included...
November 2017: Echocardiography
https://www.readbyqxmd.com/read/28715072/association-of-mean-platelet-volume-with-presence-of-non-viable-myocardium-in-ischaemic-cardiomyopathy
#9
Semi Ozturk, Ahmed Seyfettin Gürbüz, Süleyman Çağan Efe, Mehmet Fatih Yılmaz, Özden Savaş Den Hartigh, Ferahnaz Çınaral Sayın, Cevat Kırma
BACKGROUND: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. AIM: The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM)...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28700405/characterization-of-viability-scarring-and-hibernation-of-the-myocardium-supplied-by-epicardial-coronary-arteries-with-low-flow-grades
#10
Abdallah Al-Mohammad, Murdoch Y Norton, Andrew E Welch, Stephen Walton
OBJECTIVE: The aim of this study was to analyse the relationship between reduced coronary artery flow and myocardial viability, scarring and hibernation. PATIENTS AND METHODS: Coronary flow grades and collateral vessels were scored using the thrombolysis in myocardial infarction trial (TIMI) and the Rentrop and Cohen scoring systems, respectively. N-ammonia and fluorine-18-fluorodeoxyglucose (F-FDG) are the perfusion and metabolic markers on PET, respectively. The left ventricle was divided into three coronary territories...
August 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28577280/the-role-of-myocardial-viability-in-contemporary-cardiac-practice
#11
REVIEW
Abdelrahman Jamiel, Mohamad Ebid, Amjad M Ahmed, Dalia Ahmed, Mouaz H Al-Mallah
Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short- and long-term outcome. There is a considerable collection of observational data showing substantial improvement in patients with significant left ventricular dysfunction when the need for revascularization is guided by preoperative assessment of viability and hibernation...
July 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28120944/identification-of-cardiac-progenitors-that-survive-in-the-ischemic-human-heart-after-ventricular-myocyte-death
#12
Mariko Omatsu-Kanbe, Nozomi Nozuchi, Yuka Nishino, Ken-Ichi Mukaisho, Hiroyuki Sugihara, Hiroshi Matsuura
Atypically-shaped cardiomyocytes (ACMs) are beating heart cells identified in the cultures of cardiomyocyte-removed fractions obtained from adult mouse hearts. Since ACMs spontaneously develop into beating cells in the absence of hormones or chemicals, these cells are likely to be a type of cardiac progenitors rather than stem cells. "Native ACMs" are found as small interstitial cells among ventricular myocytes that co-express cellular prion protein (PrP) and cardiac troponin T (cTnT) in mouse and human heart tissues...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28120237/hibernating-substrate-of-ventricular-tachycardia-a-three-dimensional-metabolic-and-electro-anatomic-assessment
#13
Ayman A Hussein, Michelle Niekoop, Vasken Dilsizian, Yousra Ghzally, Mohammed Abdulghani, Ramazan Asoglu, Wengen Chen, Mark Smith, Vincent See, Stephen R Shorofsky, Timm-Michael Dickfeld
PURPOSE: Hibernating myocardium (HM) is associated with sudden cardiac death (SCD). Little is known about the electrophysiological properties of HM and the basis of its association with SCD. We aimed to electrophysiologically characterize HM in patients with ventricular tachycardia (VT). METHODS: Endocardial voltage mapping, metabolic (18)FDG-positron emission tomography (PET) and perfusion (82)Rb, (201)Tl, or (99m)Tc scans were performed in 61 ischemic heart disease patients with VT...
April 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28054182/takotsubo-cardiomyopathy-fdg-myocardial-uptake-pattern-in-fasting-patients-comparison-of-pet-ct-spect-and-echo-results
#14
Malgorzata Kobylecka, Monika Budnik, Janusz Kochanowski, Radoslaw Piatkowski, Marek Chojnowski, Katarzyna Fronczewska-Wieniawska, Tomasz Mazurek, Joanna Maczewska, Michał Peller, Grzegorz Opolski, Leszek Krolicki
BACKGROUND: The aim of this study was to assess the accumulation pattern of 18F-FDG in fasting patients with takotsubo cardiomyopathy (TTC) and to correlate the results with perfusion scintigraphy and echocardiography. METHODS: 18 consecutive patients with TTC were identified by clinical symptoms, cardiac catheterization, and echocardiography. Coronary angiography (CA) and transthoracic echocardiography (TTE) were performed on the day of the onset of symptoms. An assessment of myocardial perfusion (99mTc-MIBI) and glucose metabolism (18F-FDG) was performed within 18 days...
January 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27939502/magnetic-resonance-imaging-assessment-of-cardiac-function-in-a-swine-model-of-hibernating-myocardium-3%C3%A2-months-following-bypass-surgery
#15
Laura L Hocum Stone, Cory Swingen, Christopher Holley, Christin Wright, Erin Chappuis, Herbert B Ward, Edward O McFalls, Rosemary F Kelly
OBJECTIVE: Clinical studies demonstrate delayed recovery of hibernating myocardium (HM) following coronary artery bypass graft (CABG) surgery. Cardiac magnetic resonance (CMR) imaging is effective in identifying HM in clinical settings. Our animal model of HM shows partial but incomplete functional recovery 1 month following CABG using echocardiography. This study uses CMR imaging to determine completeness of recovery 3 months post-CABG. METHODS: Swine (N = 12) underwent left anterior descending artery (LAD) 1...
March 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27553362/intramyocardial-gene-therapy-directed-to-hibernating-heart-muscle-using-a-combination-of-electromechanical-mapping-and-positron-emission-tomography
#16
Iiro Hassinen, Antti Kivelä, Antti Hedman, Antti Saraste, Juhani Knuuti, Juha Hartikainen, Seppo Ylä-Herttuala
Cardiac gene transfer for the treatment of ischemic diseases has suffered from low gene transfer efficiency and inability to target treatment genes to the ischemic myocardium. A combined method has been developed based on electromechanical mapping and radiowater PET imaging to target gene therapy to viable but ischemic and hibernating areas of the myocardium. Electromechanical NOGA mapping produces three-dimensional images of myocardium with both an electric activity map and a myocardial contractility map. These have been converted to 17-segment 2D bull's-eye maps, which were superimposed onto PET radiowater perfusion imaging maps of the myocardium...
October 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27523610/electroanatomic-properties-of-the-myocardium-predict-response-to-cd34-cell-therapy-in-patients-with-ischemic-and-nonischemic-heart-failure
#17
Gregor Zemljic, Gregor Poglajen, Matjaz Sever, Marko Cukjati, Sabina Frljak, Vesna Androcec, Peter Cernelc, François Haddad, Bojan Vrtovec
BACKGROUND: We investigated a correlation between electromechanical properties of the myocardium and response to CD34+ cell therapy in patients with chronic heart failure. METHODS AND RESULTS: We enrolled 40 patients with ischemic cardiomyopathy (ICM) and 40 with nonischemic dilated cardiomyopathy (DCM). All patients were in New York Heart Association functional class III and had a left ventricular ejection fraction (LVEF) <40%. CD34+ cells were mobilized by granulocyte colony-stimulating factor and collected via apheresis...
February 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27488429/reverse-mismatch-pattern-in-cardiac-18f-fdg-viability-pet-ct-is-not-associated-with-poor-outcome-of-revascularization-a-retrospective-outcome-study-of-91-patients-with-heart-failure
#18
Allan Kjeldsen Hansen, Michael Gejl, Kirsten Bouchelouche, Lars Poulsen Tolbod, Lars Christian Gormsen
PURPOSE: Revascularization strategies in patients with ischemic heart failure (HF) should be based on evidence of reversible perfusion defects and myocardial viability. Myocardial viability assessment is preferably based on dual isotope PET using perfusion and metabolism tracers. However, in a nonnegligible subset of HF patients, reverse mismatch (RM) pattern (reduced glucose uptake relative to perfusion) of unknown origin is observed. We aimed to investigate determinants of RM and the impact of RM on the subsequent improvement in left ventricular function by revascularization...
October 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27450736/cardioprotection-by-thymosin-beta-4
#19
REVIEW
G T Pipes, J Yang
Treatment with thymosin beta 4 (Tβ4) reduces infarct volume and preserves cardiac function in preclinical models of cardiac ischemic injury. These effects stem in part from decreased infarct size, but additional benefits are likely due to specific antifibrotic and proangiogenic activities. Injected or transgenic Tβ4 increase blood vessel growth in large and small animal models, consistent with Tβ4 converting hibernating myocardium to an actively contractile state following ischemia. Tβ4 and its degradation products have antifibrotic effects in in vitro assays and in animal models of fibrosis not related to cardiac injury...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/27283041/identification-of-angiogenesis-rich-viable-myocardium-using-rgd-dimer-based-spect-after-myocardial-infarction
#20
Min Su Lee, Hyun Soo Park, Byung Chul Lee, Jae Ho Jung, Jung Sun Yoo, Sang Eun Kim
Cardiac healing after myocardial ischemia is a complex biological process. Advances in understanding of wound healing response have paved the way for clinical testing of novel molecular imaging to improve clinical outcomes. A key factor for assessing myocardial viability after ischemic injury is the evaluation of angiogenesis accompanying increased expression of integrin αvβ3. Here, we describe the capability of an αvβ3 integrin-targeting SPECT agent, (99m)Tc-IDA-D-[c(RGDfK)]2, for identification of ischemic but viable myocardium, i...
2016: Scientific Reports
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