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Hibernating myocardium

Semi Ozturk, Ahmed Seyfettin Gürbüz, Süleyman Çağan Efe, Mehmet Fatih Yılmaz, Özden Savaş Den Hartigh, Ferahnaz Çınaral Sayın, Cevat Kırma
BACKGROUND AND AIMS: Parameters derived from complete blood count such as mean platelet volume (MPV), neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR) are recently proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Our aim is to evaluate relationship between these parameters and presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischemic cardiomyopathy...
July 17, 2017: Kardiologia Polska
Abdallah Al-Mohammad, Murdoch Y Norton, Andrew E Welch, Stephen Walton
OBJECTIVE: The aim of this study was to analyse the relationship between reduced coronary artery flow and myocardial viability, scarring and hibernation. PATIENTS AND METHODS: Coronary flow grades and collateral vessels were scored using the thrombolysis in myocardial infarction trial (TIMI) and the Rentrop and Cohen scoring systems, respectively. N-ammonia and fluorine-18-fluorodeoxyglucose (F-FDG) are the perfusion and metabolic markers on PET, respectively. The left ventricle was divided into three coronary territories...
August 2017: Nuclear Medicine Communications
Abdelrahman Jamiel, Mohamad Ebid, Amjad M Ahmed, Dalia Ahmed, Mouaz H Al-Mallah
Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short- and long-term outcome. There is a considerable collection of observational data showing substantial improvement in patients with significant left ventricular dysfunction when the need for revascularization is guided by preoperative assessment of viability and hibernation...
June 3, 2017: Heart Failure Reviews
Mariko Omatsu-Kanbe, Nozomi Nozuchi, Yuka Nishino, Ken-Ichi Mukaisho, Hiroyuki Sugihara, Hiroshi Matsuura
Atypically-shaped cardiomyocytes (ACMs) are beating heart cells identified in the cultures of cardiomyocyte-removed fractions obtained from adult mouse hearts. Since ACMs spontaneously develop into beating cells in the absence of hormones or chemicals, these cells are likely to be a type of cardiac progenitors rather than stem cells. "Native ACMs" are found as small interstitial cells among ventricular myocytes that co-express cellular prion protein (PrP) and cardiac troponin T (cTnT) in mouse and human heart tissues...
January 25, 2017: Scientific Reports
Ayman A Hussein, Michelle Niekoop, Vasken Dilsizian, Yousra Ghzally, Mohammed Abdulghani, Ramazan Asoglu, Wengen Chen, Mark Smith, Vincent See, Stephen R Shorofsky, Timm-Michael Dickfeld
PURPOSE: Hibernating myocardium (HM) is associated with sudden cardiac death (SCD). Little is known about the electrophysiological properties of HM and the basis of its association with SCD. We aimed to electrophysiologically characterize HM in patients with ventricular tachycardia (VT). METHODS: Endocardial voltage mapping, metabolic (18)FDG-positron emission tomography (PET) and perfusion (82)Rb, (201)Tl, or (99m)Tc scans were performed in 61 ischemic heart disease patients with VT...
January 25, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Malgorzata Kobylecka, Monika Budnik, Janusz Kochanowski, Radoslaw Piatkowski, Marek Chojnowski, Katarzyna Fronczewska-Wieniawska, Tomasz Mazurek, Joanna Maczewska, Michał Peller, Grzegorz Opolski, Leszek Krolicki
BACKGROUND: The aim of this study was to assess the accumulation pattern of 18F-FDG in fasting patients with takotsubo cardiomyopathy (TTC) and to correlate the results with perfusion scintigraphy and echocardiography. METHODS: 18 consecutive patients with TTC were identified by clinical symptoms, cardiac catheterization, and echocardiography. Coronary angiography (CA) and transthoracic echocardiography (TTE) were performed on the day of the onset of symptoms. An assessment of myocardial perfusion (99mTc-MIBI) and glucose metabolism (18F-FDG) was performed within 18 days...
January 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Laura L Hocum Stone, Cory Swingen, Christopher Holley, Christin Wright, Erin Chappuis, Herbert B Ward, Edward O McFalls, Rosemary F Kelly
OBJECTIVE: Clinical studies demonstrate delayed recovery of hibernating myocardium (HM) following coronary artery bypass graft (CABG) surgery. Cardiac magnetic resonance (CMR) imaging is effective in identifying HM in clinical settings. Our animal model of HM shows partial but incomplete functional recovery 1 month following CABG using echocardiography. This study uses CMR imaging to determine completeness of recovery 3 months post-CABG. METHODS: Swine (N = 12) underwent left anterior descending artery (LAD) 1...
March 2017: Journal of Thoracic and Cardiovascular Surgery
Iiro Hassinen, Antti Kivelä, Antti Hedman, Antti Saraste, Juhani Knuuti, Juha Ek Hartikainen, Seppo Ylä-Herttuala
Cardiac gene transfer for the treatment of ischemic diseases has suffered from low gene transfer efficiency and inability to target treatment genes to the ischemic myocardium. We have developed a combined method based on electromechanical mapping and radiowater PET imaging to target gene therapy to viable but ischemic and hibernating areas of the myocardium. Electromechanical NOGA mapping produces 3D images of myocardium with both an electric activity map and a myocardial contractility map. These have been converted to 17-segment 2D bull's eye maps which were superimposed onto PET radiowater perfusion imaging maps of the myocardium...
August 23, 2016: Human Gene Therapy
Gregor Zemljic, Gregor Poglajen, Matjaz Sever, Marko Cukjati, Sabina Frljak, Vesna Androcec, Peter Cernelc, François Haddad, Bojan Vrtovec
BACKGROUND: We investigated a correlation between electromechanical properties of the myocardium and response to CD34+ cell therapy in patients with chronic heart failure. METHODS AND RESULTS: We enrolled 40 patients with ischemic cardiomyopathy (ICM) and 40 with nonischemic dilated cardiomyopathy (DCM). All patients were in New York Heart Association functional class III and had a left ventricular ejection fraction (LVEF) <40%. CD34+ cells were mobilized by granulocyte colony-stimulating factor and collected via apheresis...
February 2017: Journal of Cardiac Failure
Allan Kjeldsen Hansen, Michael Gejl, Kirsten Bouchelouche, Lars Poulsen Tolbod, Lars Christian Gormsen
PURPOSE: Revascularization strategies in patients with ischemic heart failure (HF) should be based on evidence of reversible perfusion defects and myocardial viability. Myocardial viability assessment is preferably based on dual isotope PET using perfusion and metabolism tracers. However, in a nonnegligible subset of HF patients, reverse mismatch (RM) pattern (reduced glucose uptake relative to perfusion) of unknown origin is observed. We aimed to investigate determinants of RM and the impact of RM on the subsequent improvement in left ventricular function by revascularization...
October 2016: Clinical Nuclear Medicine
G T Pipes, J Yang
Treatment with thymosin beta 4 (Tβ4) reduces infarct volume and preserves cardiac function in preclinical models of cardiac ischemic injury. These effects stem in part from decreased infarct size, but additional benefits are likely due to specific antifibrotic and proangiogenic activities. Injected or transgenic Tβ4 increase blood vessel growth in large and small animal models, consistent with Tβ4 converting hibernating myocardium to an actively contractile state following ischemia. Tβ4 and its degradation products have antifibrotic effects in in vitro assays and in animal models of fibrosis not related to cardiac injury...
2016: Vitamins and Hormones
Min Su Lee, Hyun Soo Park, Byung Chul Lee, Jae Ho Jung, Jung Sun Yoo, Sang Eun Kim
Cardiac healing after myocardial ischemia is a complex biological process. Advances in understanding of wound healing response have paved the way for clinical testing of novel molecular imaging to improve clinical outcomes. A key factor for assessing myocardial viability after ischemic injury is the evaluation of angiogenesis accompanying increased expression of integrin αvβ3. Here, we describe the capability of an αvβ3 integrin-targeting SPECT agent, (99m)Tc-IDA-D-[c(RGDfK)]2, for identification of ischemic but viable myocardium, i...
2016: Scientific Reports
Laura Hocum Stone, Tammy A Butterick, Cayla Duffy, Corey Swingen, Herbert B Ward, Rosemary F Kelly, Edward O McFalls
There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo...
August 2016: Journal of Cardiovascular Translational Research
Adam K McDiarmid, Pierpaolo Pellicori, John G Cleland, Sven Plein
The terms used to describe different states of myocardial health and disease are poorly defined. Imprecision and inconsistency in nomenclature can lead to difficulty in interpreting and applying trial outcomes to clinical practice. In particular, the terms 'viable' and 'hibernating' are commonly applied interchangeably and incorrectly to myocardium that exhibits chronic contractile dysfunction in patients with ischaemic heart disease. The range of inherent differences amongst imaging modalities used to define myocardial health and disease add further challenges to consistent definitions...
April 1, 2017: European Heart Journal
Pavan Patel, Alexander Ivanov, Kumudha Ramasubbu
The initial observation of functional recovery in dysfunctional myocardium following revascularization led to the introduction of the concept of hibernating myocardium. Since then, the pathophysiologic basis of hibernating myocardium has been well described. Multiple imaging modalities have been utilized to prospectively detect viable myocardium and thus predict its functional recovery following revascularization. It has been hypothesized that viability imaging will be instrumental in the selection of patients with ischemic cardiomyopathy likely to benefit from revascularization...
June 2016: Current Atherosclerosis Reports
Kyriakos Anastasiadis, Polychronis Antonitsis, Stephen Westaby, Ajan Reginald, Sabena Sultan, Argirios Doumas, George Efthimiadis, Martin John Evans
Heart failure is a life-limiting condition affecting over 40 million patients worldwide. Ischemic cardiomyopathy (ICM) is the most common cause. This study investigates in situ cardiac regeneration utilizing precision delivery of a novel mesenchymal precursor cell type (iMP) during coronary artery bypass surgery (CABG) in patients with ischemic cardiomyopathy (LVEF < 40 %). The phase IIa safety study was designed to enroll 11 patients. Preoperative scintigraphy imaging (SPECT) was used to identify hibernating myocardium not suitable for conventional myocardial revascularization for iMP implantation...
June 2016: Journal of Cardiovascular Translational Research
Rahul N Sawlani, Jeremy D Collins
Cardiac magnetic resonance imaging (CMRI) has been under development for the past four decades and has more recently become an essential tool in the evaluation of ischemic heart disease (IHD). It is the reference standard for quantification of both right and left ventricular volume and function and, after landmark work published in the New England Journal of Medicine in 2000, has proven effective in identifying hibernating myocardium, or hypokinetic myocardium that will recover after revascularization. More recent literature continues to support both delayed enhancement imaging and CMRI stress perfusion as essential tools in evaluating IHD...
May 2016: Current Atherosclerosis Reports
F Maranta, L Tondi, E Agricola, A Margonato, O Rimoldi, Paolo G Camici
Ivabradine is an effective treatment for angina in patients with stable coronary artery disease (CAD) and for heart failure. Experiments in a canine model have shown that ivabradine reduces both acute left ventricular (LV) dysfunction and post-ischaemic stunning. Aim of this study was to investigate the effect of ivabradine on LV dysfunction and stunning in patients with CAD and exercise-inducible ischaemia. Fifteen patients with ejection fraction >40 % and heart rate >70 bpm were enrolled. After pharmacologic washout, echocardiography was performed at rest, at peak treadmill exercise and during recovery until return to baseline...
November 2015: Basic Research in Cardiology
Shahar Lavi, Mistre Alemayehu, David McCarty, James Warrington, Ronit Lavi
BACKGROUND: Sevoflurane is an inhalation anesthetic that has cardioprotective effects. There is limited information regarding its use outside of the operating room and its potential protective effect for patients presenting with myocardial infarction. METHODS: In the Sevoflurane In Acute Myocardial Infarction trial, patients with a first acute ST-elevation myocardial infarction (STEMI) who were treated by primary percutaneous coronary intervention were randomized to inhalation of sevoflurane or oxygen (control)...
December 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Brian R Weil, Gen Suzuki, Merced M Leiker, James A Fallavollita, John M Canty
RATIONALE: Allogeneic bone marrow-derived mesenchymal stem cells (MSCs) and cardiosphere-derived cells (CDCs) have each entered clinical trials, but a direct comparison of these cell types has not been performed in a large animal model of hibernating myocardium. OBJECTIVE: Using completely blinded methodology, we compared the efficacy of global intracoronary allogeneic MSCs (icMSCs, ≈35×10(6)) and CDCs (icCDCs, ≈35×10(6)) versus vehicle in cyclosporine-immunosuppressed swine with a chronic left anterior descending coronary artery stenosis (n=26)...
September 11, 2015: Circulation Research
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