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https://www.readbyqxmd.com/read/29648964/lc-ms-ms-based-determination-of-chloramphenicol-thiamphenicol-florfenicol-and-florfenicol-amine-in-poultry-meat-from-the-punjab-pakistan
#1
Muhammad Imran, Fazal-E- Habib, Saima Majeed, Abdul Tawab, Waqar Rauf, Moazur Rahman, Muhammad Umer, Mazhar Iqbal
A simple, reliable and sensitive liquid chromatography-tandem mass spectrometry based confirmatory method was redeveloped and validated for the simultaneous determination of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in chicken muscles. The analytes were extracted from minced chicken muscle with acetonitrile and ammoniated water mixture. A second extraction with ethyl acetate was followed by evaporation and dissolution of the residue in ammoniated methanol before defatting with n-hexane...
April 12, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29508505/how-an-ordeal-becomes-the-norm-a-qualitative-exploration-of-experiences-of-self-cannulation-in-male-home-haemodialysis-patients
#2
Currie Moore, Rabiya Majeed-Ariss, Anuradha Jayanti, Sandip Mitra, Suzanne Skevington, Alison Wearden
OBJECTIVES: Despite home haemodialysis (HHD) being associated with significant health and psychosocial benefits, it remains an under-utilized dialysis modality for people with chronic kidney disease. Self-cannulation, where patients insert their own needles for dialysis, is a key component of HHD. Recent research suggests that the prospect of self-cannulation is a barrier for patients, but there is little research which examines why this is the case. The aim of this study was to explore male HHD patients' experiences and attitudes towards self-cannulation...
March 6, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29283332/diverse-signaling-pathways-and-current-status-of-molecular-targeted-treatments-for-hepatocellular-carcinoma
#3
Bushra Akhtar, Faqir Muhammad, Ali Sharif, Muhammad Furqan Akhtar, Wafa Majeed
Hepatocellular carcinoma (HCC) is one of the leading causes of death associated with cancer. Various molecular mechanisms are involved in HCC development. Alterations in these molecular mechanisms include chromosomal instability, gene mutations, and variations in protein expressions. A number of cell signaling pathways that are associated with the occurrence of apoptosis, cell proliferation, and angiogenesis provide new prospects for the development of HCC treatments. Newly designed, potential therapeutic regimens target specific receptors, kinases, and vital proteins...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29065669/a-granular-ontology-model-for-maternal-and-child-health-information-system
#4
Saadia Ismail, Majed Alshmari, Khalid Latif, Hafiz Farooq Ahmad
In several developing countries, maternal and child health indicators trail behind the international targets set by the UN as Millennium or Sustainable Development Goals. One of the reasons is poor and nonstandardized maternal health record keeping that affects data quality. Effective decision making to improve public healthcare depends essentially on the availability of reliable data. Therefore, the aim of this research is the design and development of the standard compliant data access model for maintaining maternal and child health data to enable the effective exchange of healthcare data...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/28944220/determinants-for-further-wishes-for-cosmetic-and-reconstructive-interventions-in-1652-patients-with-surgical-treated-carcinomas-of-the-oral-cavity
#5
Henrik Holtmann, Simon Spalthoff, Nils-Claudius Gellrich, Jörg Handschel, Julian Lommen, Norbert R Kübler, Gertrud Krüskemper, Majeed Rana, Karoline Sander
BACKGROUND: The impairment of the appearance is a major problem for patients with carcinomas of the oral cavity. These patients want to recover their preoperative facial appearance. Some do not realize that this is not always possible and hence develop a desire for further cosmetic and reconstructive surgery (CRS) which often causes psychological problems. METHOD: The desire of patients for CRS (N = 410; 26%) has been acquired in this DÖSAK rehab study including multiple reasons such as medical, functional, aesthetic and psychosocial aspects...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28883185/factors-influencing-the-implementation-and-distribution-of-clinical-decision-support-systems-cdss
#6
Benjamin R Kux, Raphael W Majeed, Janko Ahlbrandt, Rainer Röhrig
Clinical Decision Support Systems (CDSS) can have positive effects on quality of care measures, yet have not gained widespread traction in healthcare. This study sought to determine and evaluate barriers and facilitators to CDSS implementation and distribution. Based on 768 systems identified in a literature review we conducted semi-structured telephone interviews with 54 system developers in 16 countries. Qualitative analysis led to the identification of 66 key factors influencing implementation. Central issues evolved around CDSS properties, quality and integration, as well as usability, user related factors, internal marketing, resource issues and collaborations with emphasis partly on topics differing from existing research...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28799658/dynamic-blowout-risk-analysis-using-loss-functions
#7
Majeed Abimbola, Faisal Khan
Most risk analysis approaches are static; failing to capture evolving conditions. Blowout, the most feared accident during a drilling operation, is a complex and dynamic event. The traditional risk analysis methods are useful in the early design stage of drilling operation while falling short during evolving operational decision making. A new dynamic risk analysis approach is presented to capture evolving situations through dynamic probability and consequence models. The dynamic consequence models, the focus of this study, are developed in terms of loss functions...
August 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28736673/detection-theory-for-accurate-and-non-invasive-skin-cancer-diagnosis-using-dynamic-thermal-imaging
#8
Sebastián E Godoy, Majeed M Hayat, David A Ramirez, Stephen A Myers, R Steven Padilla, Sanjay Krishna
Skin cancer is the most common cancer in the United States with over 3.5M annual cases. Presently, visual inspection by a dermatologist has good sensitivity (> 90%) but poor specificity (< 10%), especially for melanoma, which leads to a high number of unnecessary biopsies. Here we use dynamic thermal imaging (DTI) to demonstrate a rapid, accurate and non-invasive imaging system for detection of skin cancer. In DTI, the lesion is cooled down and the thermal recovery is recorded using infrared imaging. The thermal recovery curves of the suspected lesions are then utilized in the context of continuous-time detection theory in order to define an optimal statistical decision rule such that the sensitivity of the algorithm is guaranteed to be at a maximum for every prescribed false-alarm probability...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28704244/implementation-of-a-standardized-transfusion-protocol-for-cardiac-patients-treated-with-venoarterial-extracorporeal-membrane-oxygenation-is-associated-with-decreased-blood-component-utilization-and-may-improve-clinical-outcome
#9
Christine M Cahill, Neil Blumberg, Amy E Schmidt, Peter A Knight, Amber L Melvin, Howard T Massey, Joseph M Delehanty, Seth B Zebrak, Majed A Refaai
BACKGROUND: Extracorporeal membrane oxygenation supplies oxygenated blood to the body supporting the heart and lungs. Survival rates of 20% to 50% are reported among patients receiving ECMO for cardiac arrest, severe cardiogenic shock, or failure to wean from cardiopulmonary bypass following cardiac surgery. Bleeding is one of the most common complications in ECMO patients due to coagulopathy, systemic anticoagulation, and the presence of large bore cannulas at systemic pressure. Absence of a standardized transfusion protocol in this population leads to inconsistent transfusion practices...
April 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28587644/current-and-future-perspectives-on-the-management-of-polypharmacy
#10
Mariam Molokhia, Azeem Majeed
BACKGROUND: Because of ageing populations, the growth in the number of people with multi-morbidity and greater compliance with disease-specific guidelines, polypharmacy is becoming increasingly common. Although the correct drug treatment in patients with complex medical problems can improve clinical outcomes, quality of life and life expectancy, polypharmacy is also associated with an increased risk of adverse drug events, some severe enough to result in hospital admission and even death...
June 6, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28536820/crescent-fractures-of-the-pelvis-treated-by-open-reduction-and-internal-fixation-a-critique-of-day-s-guidelines
#11
K Venugopal Menon, S S Suresh, Sivaprasad Kalyanasundaram, Jacob Varughese
INTRODUCTION: Day's classification and treatment guidelines are considered the gold standard in crescent fractures of the pelvis. The objective of this study was to retrospectively evaluate 10 surgically treated crescent fractures of the pelvis in the context of Day's recommendations. METHODS: This is a retrospective cohort study. Ten consecutive cases of crescent fractures that were treated surgically at a level 1 trauma center formed the cohort. Six were operated anteriorly, three posteriorly and one percutaneously...
December 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28454756/pregnancy-of-unknown-location-a-survey-based-evaluation-of-when-and-why-physicians-intervene
#12
Majed S Faden, Suhaib Khayat, Richard N Brown
INTRODUCTION: Management of pregnancies of unknown location (PUL) is a complex challenging clinical situation with possibilities for pitfalls. Obstetricians and gynaecologists of varied levels of training and experience from Canada and the Nordic countries were questioned about their approach when faced with PUL. METHOD: A 13-item web-based questionnaire was used to evaluate physicians' behaviors by surveying their management of a PUL encountered at different levels of human chorionic gonadotropin (hCG)...
May 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28004062/optimal-timing-of-vitamin-k-antagonist-resumption-after-upper-gastrointestinal-bleeding-a-risk-modelling-analysis
#13
Ammar Majeed, Niklas Wallvik, Joakim Eriksson, Jonas Höijer, Matteo Bottai, Margareta Holmström, Sam Schulman
The optimal timing of vitamin K antagonists (VKAs) resumption after an upper gastrointestinal (GI) bleeding, in patients with continued indication for oral anticoagulation, is uncertain. We included consecutive cases of VKA-associated upper GI bleeding from three hospitals retrospectively. Data on the bleeding location, timing of VKA resumption, recurrent GI bleeding and thromboembolic events were collected. A model was constructed to evaluate the 'total risk', based on the sum of the cumulative rates of recurrent GI bleeding and thromboembolic events, depending on the timing of VKA resumption...
February 28, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27686301/breast-cancer-treatment-in-high-risk-elderly-patients-a-challenging-situation-and-difficult-decisions
#14
Razia Bano, Amina Iqbal Khan, Waleed Zafar, Akif Abbas Zaidi, Adil Asif Zaidi, Mohammad Zulrqurnain Chaudhry, Huma Majeed Khan
OBJECTIVE: To assess whether high-risk elderly patients with aggressive tumour biology can be offered standard treatment despite having multiple comorbid conditions. METHODS: This retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data of breast cancer patients aged 65 years or above treated between 2006 and 2012,. Data was collected regarding patients' demographics, baseline clinical characteristics, comorbidities, treatment and outcomes...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27681262/slowing-the-tide-of-alcohol-use-disorders
#15
Hassan Chamsi-Pasha, Majed Chamsi-Pasha, Mohammed Ali Albar
Alcohol use disorders (AUDs)-a spectrum including at-risk drinking, alcohol abuse, dependence, and addiction-is a highly prevalent problem worldwide with a substantial economic impact. The toll of alcohol on individual health and healthcare systems is devastating. Alcohol is estimated to be the fifth leading risk factor for global disability-adjusted life years. Tackling the problem of AUD requires a comprehensive strategy that includes solid action on price, availability, and marketing of alcohol. Restricting or banning alcohol advertising may reduce exposure to the risk posed by alcohol at the individual and general population level...
September 28, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27222366/how-would-a-decision-to-leave-the-european-union-affect-medical-research-and-health-in-the-united-kingdom
#16
EDITORIAL
Azeem Majeed, Anna Hansell, Sonia Saxena, Christopher Millett, Helen Ward, Matthew Harris, Benedict Hayhoe, Josip Car, Graham Easton, Christl A Donnelly, Robert Perneczky, Marjo-Riitta Jarvelin, Majid Ezzati, Salman Rawaf, Paolo Vineis, Neil Ferguson, Elio Riboli
No abstract text is available yet for this article.
May 24, 2016: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/26976655/pragmatic-message-to-junior-doctors
#17
Hassan Chamsi-Pasha, Majed Chamsi-Pasha, Mohammed Ali Albar
Although several studies described the experience of doctors in their first postgraduate years, few shed the light on the ethical issues encountered by them. These doctors face a broad range of 'everyday' ethical challenges, from breach of confidentiality to truth-telling or improper informed consent. The daily ethical issues faced by junior doctors are not as dramatic as the major issues learned at medical school. Junior doctors have to make the best ethical decisions within the time limits available. Undergraduate medical ethics curricula should give priority to the real-life issues that doctors will face in their first years of practice...
July 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/26916686/quality-of-care-in-university-hospitals-in-saudi-arabia-a-systematic-review
#18
REVIEW
Mohammed Aljuaid, Fahmida Mannan, Zain Chaudhry, Salman Rawaf, Azeem Majeed
OBJECTIVES: To identify the key issues, problems, barriers and challenges particularly in relation to the quality of care in university hospitals in the Kingdom of Saudi Arabia (KSA), and to provide recommendations for improvement. METHODS: A systematic search was carried out using five electronic databases, for articles published between January 2004 and January 2015. We included studies conducted in university hospitals in KSA that focused on the quality of healthcare...
February 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/26351410/-partners-rather-than-just-providers%C3%A2-a-qualitative-study-on-health-care-professionals-views-on-implementation-of-multidisciplinary-group-meetings-in-the-north-west-london-integrated-care-pilot
#19
Angelos P Kassianos, Agnieszka Ignatowicz, Geva Greenfield, Azeem Majeed, Josip Car, Yannis Pappas
INTRODUCTION: Multidisciplinary group meetings are one of the key drivers of facilitating integrated care. Health care professionals attending such groups have a key role in the success of these discussions and hence, in the forming of multi-professional integrated care. The study aimed to explore the professionals' experiences and views of participating and implementing the groups in integrated care context. METHODS: A qualitative study including 25 semi-structured interviews with professionals participating in the Northwest London Integrated Care Pilot analysed using thematic content analysis...
July 2015: International Journal of Integrated Care
https://www.readbyqxmd.com/read/26241930/automated-negotiation-in-environmental-resource-management-review-and-assessment
#20
REVIEW
Faezeh Eshragh, Majeed Pooyandeh, Danielle J Marceau
Negotiation is an integral part of our daily life and plays an important role in resolving conflicts and facilitating human interactions. Automated negotiation, which aims at capturing the human negotiation process using artificial intelligence and machine learning techniques, is well-established in e-commerce, but its application in environmental resource management remains limited. This is due to the inherent uncertainties and complexity of environmental issues, along with the diversity of stakeholders' perspectives when dealing with these issues...
October 1, 2015: Journal of Environmental Management
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