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https://www.readbyqxmd.com/read/28508459/tailoring-pharmacotherapy-for-male-lower-urinary-tract-symptoms-a-prospective-multicenter-observational-trial
#1
Hyun Hwan Sung, Kwang Jin Ko, Yoon Seok Suh, Joon Chul Kim, Jong Bo Choi, Yun-Seob Song, Kyu-Sung Lee
OBJECTIVES: The aim of this study was to evaluate the pattern of tailoring and efficacy of several types of pharmacotherapy in male LUTS. METHODS: Prospectively 404 male subjects were included who were over 40 years old, had at least 3 months symptom duration, and 12 or higher international prostate symptom score (IPSS). Subjects were treated with several types of pharmacotherapy for 6 months and were evaluated with IPSS/QoL at every follow-up. Subjects were subdivided into storage (44%), nocturia (18...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28508455/a-multicenter-real-life-study-of-the-efficacy-of-an-alpha-blocker-with-or-without-anticholinergic-agent-imidafenacin-treatment-in-patients-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-storage-symptoms
#2
Seok Cho, Soon-Sun Kwon, Kwang Woo Lee, Tag Keun Yoo, Dong Gil Shin, Soo Woong Kim, Jae Hyun Bae, Hoon Choi, Young Ho Kim
AIMS: To evaluate the efficacy and safety of combination therapy comprising a short-acting anticholinergic, imidafenacin and an alpha-blocker compared with monotherapy with an alpha-blocker only in men with lower urinary tract symptoms (LUTS) and storage symptoms. METHODS: The 12-week, prospective, double-blind, randomised trial enrolled men with LUTS and storage symptom. The inclusion criteria were a total International Prostate Symptom Score (IPSS) ≥12, an IPSS question 4 score ≥2, ≥8 micturitions in 24 hours, and a prostate volume >20 mL...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28499788/nocturia-and-prevalence-of-depressive-symptoms-in-japanese-patients-with-type-2-diabetes-mellitus-the-dogo-study
#3
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Sayaka Kanzaki, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
OBJECTIVES: No studies have investigated the association between nocturia and depressive symptoms in patients with type 2 diabetes mellitus. Because nocturia and depressive symptoms are common in patients with type 2 diabetes, we examined this association in Japanese patients with type 2 diabetes. METHODS: We studied 762 Japanese patients with type 2 diabetes. A self-administered questionnaire was used to collect information about the variables under study. The subjects were divided into 3 groups according to their nocturnal micturition: 1) no nocturia; 2) mild nocturia (1 void per night) and 3) moderate to severe nocturia (2 or more voids per night)...
May 9, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28497089/impact-of-oral-capsule-of-peganum-harmala-on-alleviating-urinary-symptoms-in-men-with-benign-prostatic-hyperplasia-a-randomized-clinical-trial
#4
Majid Shirani-Boroujeni, Saeed Heidari-Soureshjani, Zahra Keivani Hafshejani
Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH. Patients and Methods: In this single blind clinical trial study, 90 patients diagnosed with BPH and LUTS, based on international prostate standard survey (IPSS) were divided into three groups...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28490209/retrospective-analysis-in-46-women-with-vulvovaginal-atrophy-treated-with-ospemifene-for-12-weeks-improvement-in-overactive-bladder-symptoms
#5
Michele Carlo Schiavi, Marzio Angelo Zullo, Pierangelo Faiano, Ottavia D'Oria, Giovanni Prata, Vanessa Colagiovanni, Andrea Giannini, Chiara Di Tucci, Giorgia Perniola, Violante Di Donato, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici
AIMS: The aim of this study was to assess the effectiveness and safety of ospemifene in the improvement of overactive bladder (OAB) symptoms in postmenopausal women affected by vulvovaginal atrophy (VVA). METHODS: Forty-six postmenopausal patients affected by VVA with OAB syndrome were enrolled for the study. All patients received Ospemifene 60 mg for 12 weeks. Clinical examination, 3-day voiding diary, urodynamic testing, ultrasound measurement of endometrial and bladder wall thickness (BWT) and the Vaginal Health Index (VHI) were performed at baseline and 12 weeks...
May 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28482433/-clinical-characteristics-of-13-neuroendocrine-prostate-cancer-patients
#6
W H Zhang, T G Si, X L Yang, B Yang, C F Liu, H P Yu, W G Xing, Z Guo
Objective: To explore the radiological, pathological features and clinical characteristics of neuroendocrine prostate cancer patients(NEPC). Methods: The clinical characteristics and pathology data of 13 neuroendocrine prostate cancer patients treated in the Affiliated Hospital of Tianjin Medical University from January 2004 to January 2015 were analyzed retrospectively. Results: Of all 13 patients, three cases were primally diagnosed small cell cancer, and 10 cases were translated to neuroendocrine type from adenocarcinoma after endocrine therapy...
May 9, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28480984/clinical-comparison-of-intravesical-hyaluronic-acid-and-chondroitin-sulfate-therapies-in-the-treatment-of-bladder-pain-syndrome-interstitial-cystitis
#7
Ömer Gülpınar, Barış Esen, Aytaç Kayış, Mehmet İlker Gökçe, Evren Süer
INTRODUCTION: Intravesical glucosaminoglycan (GAG) replacement therapies are commonly used in the treatment of bladder pain syndrome (BPS)/interstitial cystitis (IC). Different intravesical glucosaminoglycan products are currently available. In this prospective study, clinical efficacy of chondroitin sulfate and hyaluronic acid are compared in patients with BPS/IC. METHODS: Patients were randomized to CS and HA groups. All patients were evaluated for visual analogue pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), voiding diary for frequency/nocturia, and mean urine volume per void at the beginning of the therapy and after 6 months...
May 8, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28479240/fesoterodine-for-the-treatment-of-nocturnal-urgency-in-patients-with-overactive-bladder-syndrome-an-analysis-of-responders-and-non-responders
#8
Johnathan A Khusid, Jeffrey P Weiss, Martin O Carlsson, Erin K Mangan
PURPOSE: A recent study demonstrated improvement of nocturnal urgency in patients with overactive bladder (OAB) when treated with fesoterodine. The current study aims to determine which bladder diary parameters predict response to fesoterodine in these patients. MATERIALS AND METHODS: Patients with nocturnal urgency completed a 2-week, single-blind, placebo run-in, followed by 1:1 double-blind randomization to 12 weeks of fesoterodine or placebo. We analysed changes from baseline to week 12 of bladder diary parameters including actual number night voids (ANV, total # nocturia episodes), maximum voided volume (MVV), nocturnal bladder capacity (NBC), nocturnal bladder capacity index (NBCi = ANV- NUV/MVV-1), nocturnal urine volume (NUV), nocturia index (Ni = NUV/MVV), nocturnal polyuria index and (NPi = NUV/24 hour volume)...
May 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28469721/vitamin-d-deficiency-and-interleukin-17-relationship-in-severe-obstructive-sleep-apnea-hypopnea-syndrome
#9
Sonia Toujani, Wajih Kaabachi, Meriem Mjid, Kamel Hamzaoui, Jouda Cherif, Majed Beji
PURPOSE: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea-hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17). METHODS: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected...
April 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28464331/does-deep-brain-stimulation-improve-lower-urinary-tract-symptoms-in-parkinson-s-disease
#10
Lambertus P Witte, Vincent J J Odekerken, Judith A Boel, P Richard Schuurman, Lara C Gerbrandy-Schreuders, Rob M A de Bie
AIMS: To investigate whether deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) or the subthalamic nucleus (STN) improve lower urinary tract symptoms (LUTS) in advanced Parkinson's disease (PD). METHODS: An exploratory post-hoc analysis was performed of specific LUTS items of questionnaires used in a randomized clinical trial with 128 patients (NSTAPS study). First, we compared scores on LUTS items at baseline and 12 months for the GPi DBS and STN DBS group separately...
May 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28461989/is-overactive-bladder-in-the-female-surgically-curable-by-ligament-repair
#11
Bernhard Liedl, Hiromi Inoue, Yuki Sekiguchi, Max Haverfield, Peter Richardson, Alexander Yassourides, Florian Wagenlehner
INTRODUCTION: Overactive bladder (OAB) symptoms (urge, frequency, nocturia) are not generally considered surgically curable by learning institutions. The Integral Theory hypothesizes that OAB is a prematurely activated, but normal micturition reflex caused by loose suspensory ligaments and potentially curable surgically by repairing such ligaments. To test this hypothesis by surgical repair of loose cardinal and uterosacral ligaments in patients with 2(nd) degree or greater uterine/apical prolapse...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28459143/testosterone-deficiency-and-nocturia-a-review
#12
REVIEW
Kazuyoshi Shigehara, Koji Izumi, Atsushi Mizokami, Mikio Namiki
Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels...
April 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28452451/the-impact-of-nerve-sparing-robot-assisted-radical-prostatectomy-on-lower-urinary-tract-function-prospective-assessment-of-patient-reported-outcomes-and-frequency-volume-charts
#13
Nobuhiro Haga, Junya Hata, Kanako Matsuoka, Tomoyuki Koguchi, Hidenori Akaihata, Masao Kataoka, Yuichi Sato, Soichiro Ogawa, Kei Ishibashi, Yoshiyuki Kojima
AIMS: To elucidate the effects of a nerve-sparing (NS) procedure on lower urinary tract symptoms (LUTS) and urinary function after robot-assisted radical prostatectomy (RARP), the associations between the NS procedure and LUTS and urinary function were investigated. METHODS: The participants in this study were 200 consecutive patients who underwent RARP. These patients were categorized into unilateral and bilateral NS groups and the non-NS group. The International Prostate Symptom Score (IPSS), quality of life (QOL) index, frequency-volume chart, uroflowmetry, 1-h pad test, and the 5-item International Index of Erectile Function (IIEF-5) questionnaire were evaluated before and after RARP...
April 28, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28444710/can-we-define-and-characterize-the-aging-lower-urinary-tract-ici-rs-2015
#14
REVIEW
Bahareh Vahabi, Adrian S Wagg, Peter F W M Rosier, Kevin L J Rademakers, Marie-Astrid Denys, Michel Pontari, Thelma Lovick, Francoise A Valentini, Pierre P Nelson, Karl-Erik Andersson, Christopher H Fry
The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the variable of interest or a time-dependent accumulation of factors that impact on LUT function at rates that differ between individuals. In particular, the accumulation of conditions or agents due to inflammatory states or tissue ischemia is important. Much of the above has been concerned with changes to bladder function and morphology...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28425062/patients-lived-experiences-of-nocturia-a-qualitative-study-of-the-evening-the-night-and-the-next-day
#15
Andrew Trigg, Fredrik L Andersson, Natalie V J Aldhouse, Donald L Bliwise, Helen Kitchen
BACKGROUND: Nocturia, waking to urinate two or more times during the night, is a chronic condition associated with significant patient burden due to sleep disruption. This study aimed to explore the lived experiences of patients with nocturia in terms of the disruption to their lives during the night and day. METHODS: Adult patients in the US diagnosed with nocturia were recruited for face-to-face qualitative interviews. Thematic analysis of patients' narratives, taking a phenomenological interpretative approach, summarised their experiences throughout the night and day, including any apparent contrasts between patients...
April 19, 2017: Patient
https://www.readbyqxmd.com/read/28418102/efficacy-and-safety-of-combinations-of-mirabegron-and-solifenacin-compared-with-monotherapy-and-placebo-in-patients-with-overactive-bladder-synergy-study
#16
Sender Herschorn, Christopher R Chapple, Paul Abrams, Salvador Arlandis, David Mitcheson, Kyu-Sung Lee, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Rob van Maanen, Dudley Robinson
Overactive bladder (OAB) syndrome is characterized by urinary urgency, with or without urgency urinary incontinence, usually accompanied by increased daytime frequency and nocturia, in the absence of urinary tract infection (UTI) or other obvious pathology [1]. Urgency urinary incontinence is present in approximately one-third of cases [2], but is not a prerequisite. However, of all the OAB symptoms, it has the greatest impact on quality of life (QoL) [3, 4], and is associated with significantly lower productivity and higher healthcare resource utilization [5]...
April 18, 2017: BJU International
https://www.readbyqxmd.com/read/28416260/late-genitourinary-toxicity-outcomes-in-300-prostate-cancer-patients-treated-with-dose-escalated-image-guided-intensity-modulated-radiotherapy
#17
K Byrne, G Hruby, A Kneebone, D Whalley, L Guo, P McCloud, T Eade
AIMS: To quantify and qualify late genitourinary toxicity in a cohort of patients with localised prostate cancer treated with image-guided intensity-modulated radiotherapy (IMRT) to doses ≥78 Gy. MATERIALS AND METHODS: The cohort consisted of 300 patients treated with definitive dose-escalated IMRT between 2007 and 2013. Ninety-seven patients received 78-80 Gy in 38 fractions, and 203 received 82-84 Gy in 40 fractions. International Prostate Symptoms Score (IPSS) and supplemental quality of life data were recorded at baseline, weekly during treatment and at follow-up...
April 14, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28415952/effective-treatment-of-ketamine-associated-cystitis-with-botulinum-toxin-type-a-injection-combined-with-bladder-hydrodistention
#18
Jianfeng Zeng, Haibiao Lai, Dongxiang Zheng, Liang Zhong, Zhifeng Huang, Shanyun Wang, Weiwei Zou, Lianbo Wei
Objective Ketamine-associated cystitis (KAC) has been described in a few case reports, but its treatment in a relatively large number of patients has not been documented. This study aimed to describe our experience of treatment of 36 patients with KAC. Methods Thirty-six patients (30 males and 6 females, aged 19-38 years) with KAC, who had previously taken a muscarinic receptor blocker and/or antibiotics, but without symptomatic relief, were treated with botulinum toxin A injection combined with bladder hydrodistention...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28411070/development-and-initial-testing-of-the-flow-instrument-a-novel-assessment-of-lower-urinary-tract-symptoms-in-men
#19
Kelvin A Moses, Daniel Heslop, Derek M Griffith, Arturo Holmes, Lisa Sherden, Consuelo H Wilkins, Kenneth A Wallston
PURPOSE: To develop a method of assessing lower urinary tract symptoms (LUTS) regardless of literacy/numeracy. MATERIALS AND METHODS: We convened focus groups and developed a questionnaire based on four identified domains of urinary function: Frequency, Incontinence (Leakage), Nocturia (Overnight voiding), and Weak stream (FLOW). We pilot tested the novel questionnaire in 64 men and performed quantitative analysis to determine internal consistency. Criterion validity was established via direct comparison to the American Urological Association Symptom Score (AUA-SS) in a larger cohort of 161 men...
April 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28407347/severe-depression-and-anxiety-in-women-with-overactive-bladder
#20
Iane Glauce Ribeiro Melotti, Cássia Raquel Teatin Juliato, Mariana Tanaka, Cassio Luiz Zanettini Riccetto
AIM: Depression and anxiety are prevalent psychiatric conditions and are associated with overactive bladder. The objective of this study was to determine prevalence and severity of anxiety and depression associated with overactive bladder (OAB) in women. METHODS: 274 women with clinical diagnosis of OAB were recruited from 2012 to 2015. They were submitted to the International Consultation on Incontinence Questionnaire-Overactive Bladder (ICIQ-OAB), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI)...
April 13, 2017: Neurourology and Urodynamics
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