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https://www.readbyqxmd.com/read/28444710/can-we-define-and-characterize-the-aging-lower-urinary-tract-ici-rs-2015
#1
REVIEW
Bahareh Vahabi, Adrian S Wagg, Peter F W M Rosier, Kevin L J Rademakers, Marie-Astrid Denys, Michel Pontari, Thelma Lovick, Francoise A Valentini, Pierre P Nelson, Karl-Erik Andersson, Christopher H Fry
The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the variable of interest or a time-dependent accumulation of factors that impact on LUT function at rates that differ between individuals. In particular, the accumulation of conditions or agents due to inflammatory states or tissue ischemia is important. Much of the above has been concerned with changes to bladder function and morphology...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28425062/patients-lived-experiences-of-nocturia-a-qualitative-study-of-the-evening-the-night-and-the-next-day
#2
Andrew Trigg, Fredrik L Andersson, Natalie V J Aldhouse, Donald L Bliwise, Helen Kitchen
BACKGROUND: Nocturia, waking to urinate two or more times during the night, is a chronic condition associated with significant patient burden due to sleep disruption. This study aimed to explore the lived experiences of patients with nocturia in terms of the disruption to their lives during the night and day. METHODS: Adult patients in the US diagnosed with nocturia were recruited for face-to-face qualitative interviews. Thematic analysis of patients' narratives, taking a phenomenological interpretative approach, summarised their experiences throughout the night and day, including any apparent contrasts between patients...
April 19, 2017: Patient
https://www.readbyqxmd.com/read/28418102/efficacy-and-safety-of-combinations-of-mirabegron-and-solifenacin-compared-with-monotherapy-and-placebo-in-patients-with-overactive-bladder-synergy-study
#3
Sender Herschorn, Christopher R Chapple, Paul Abrams, Salvador Arlandis, David Mitcheson, Kyu-Sung Lee, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Rob van Maanen, Dudley Robinson
Overactive bladder (OAB) syndrome is characterized by urinary urgency, with or without urgency urinary incontinence, usually accompanied by increased daytime frequency and nocturia, in the absence of urinary tract infection (UTI) or other obvious pathology [1]. Urgency urinary incontinence is present in approximately one-third of cases [2], but is not a prerequisite. However, of all the OAB symptoms, it has the greatest impact on quality of life (QoL) [3, 4], and is associated with significantly lower productivity and higher healthcare resource utilization [5]...
April 18, 2017: BJU International
https://www.readbyqxmd.com/read/28416260/late-genitourinary-toxicity-outcomes-in-300-prostate-cancer-patients-treated-with-dose-escalated-image-guided-intensity-modulated-radiotherapy
#4
K Byrne, G Hruby, A Kneebone, D Whalley, L Guo, P McCloud, T Eade
AIMS: To quantify and qualify late genitourinary toxicity in a cohort of patients with localised prostate cancer treated with image-guided intensity-modulated radiotherapy (IMRT) to doses ≥78 Gy. MATERIALS AND METHODS: The cohort consisted of 300 patients treated with definitive dose-escalated IMRT between 2007 and 2013. Ninety-seven patients received 78-80 Gy in 38 fractions, and 203 received 82-84 Gy in 40 fractions. International Prostate Symptoms Score (IPSS) and supplemental quality of life data were recorded at baseline, weekly during treatment and at follow-up...
April 14, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28415952/effective-treatment-of-ketamine-associated-cystitis-with-botulinum-toxin-type-a-injection-combined-with-bladder-hydrodistention
#5
Jianfeng Zeng, Haibiao Lai, Dongxiang Zheng, Liang Zhong, Zhifeng Huang, Shanyun Wang, Weiwei Zou, Lianbo Wei
Objective Ketamine-associated cystitis (KAC) has been described in a few case reports, but its treatment in a relatively large number of patients has not been documented. This study aimed to describe our experience of treatment of 36 patients with KAC. Methods Thirty-six patients (30 males and 6 females, aged 19-38 years) with KAC, who had previously taken a muscarinic receptor blocker and/or antibiotics, but without symptomatic relief, were treated with botulinum toxin A injection combined with bladder hydrodistention...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28411070/development-and-initial-testing-of-the-flow-instrument-a-novel-assessment-of-lower-urinary-tract-symptoms-in-men
#6
Kelvin A Moses, Daniel Heslop, Derek M Griffith, Arturo Holmes, Lisa Sherden, Consuelo H Wilkins, Kenneth A Wallston
PURPOSE: To develop a method of assessing lower urinary tract symptoms (LUTS) regardless of literacy/numeracy. MATERIALS AND METHODS: We convened focus groups and developed a questionnaire based on four identified domains of urinary function: Frequency, Incontinence (Leakage), Nocturia (Overnight voiding), and Weak stream (FLOW). We pilot tested the novel questionnaire in 64 men and performed quantitative analysis to determine internal consistency. Criterion validity was established via direct comparison to the American Urological Association Symptom Score (AUA-SS) in a larger cohort of 161 men...
April 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28407347/severe-depression-and-anxiety-in-women-with-overactive-bladder
#7
Iane Glauce Ribeiro Melotti, Cássia Raquel Teatin Juliato, Mariana Tanaka, Cassio Luiz Zanettini Riccetto
AIM: Depression and anxiety are prevalent psychiatric conditions and are associated with overactive bladder. The objective of this study was to determine prevalence and severity of anxiety and depression associated with overactive bladder (OAB) in women. METHODS: 274 women with clinical diagnosis of OAB were recruited from 2012 to 2015. They were submitted to the International Consultation on Incontinence Questionnaire-Overactive Bladder (ICIQ-OAB), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI)...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28406126/correlation-between-international-prostate-symptom-score-and-uroflowmetry-in-patients-with-benign-prostatic-hyperplasia
#8
C K Oranusi, A E Nwofor, O Mbonu
OBJECTIVE: To determine the correlation between severity of symptoms using the International Prostate Symptom Score (IPSS) and uroflowmetry in patients with lower urinary tract symptoms-benign prostatic hyperplasia (LUTS-BPH). PATIENTS AND METHODS: We prospectively collected data from 51 consecutive men, who presented with LUTS-BPH at the Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria, from January 2012 through December, 2014. Symptom severity was assessed using the self-administered IPSS questionnaire...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28400168/qualitative-exploration-of-the-patient-experience-of-underactive-bladder
#9
Alan D Uren, Nikki Cotterill, Christopher Harding, Christopher Hillary, Christopher Chapple, Monique Klaver, Dominique Bongaerts, Zalmai Hakimi, Paul Abrams
BACKGROUND: Underactive bladder (UAB) is considered the symptom complex associated with the urodynamic diagnosis of detrusor underactivity. OBJECTIVE: The aim of this research was to investigate the patient reported experience of the symptoms, signs, and impact of UAB. This research is also part of the initial qualitative phase for the development of a new patient reported outcome measure for the assessment of UAB. DESIGN, SETTING, AND PARTICIPANTS: Qualitative methods were used to understand the experience of UAB from a patient perspective, in a purposive sample of male (n=29) and female (n=15) patients aged 27-88 yr (mean: 64 yr), diagnosed with a primary diagnosis of detrusor underactivity, with or without coexisting urological conditions...
April 8, 2017: European Urology
https://www.readbyqxmd.com/read/28392180/the-relationship-between-diabetes-diabetes-severity-diabetes-biomarkers-and-the-presence-of-lower-urinary-tract-symptoms-findings-from-the-national-health-and-nutrition-examination-survey-nhanes
#10
Christopher A Tam, Brian T Helfand, Bradley A Erickson
OBJECTIVE: To characterize the associations between diabetes mellitus (DM) and lower urinary tract symptoms (LUTS). This study focuses on the relationships between specific diabetic characteristics (e.g. severity, biomarkers) and the prevalence of LUTS. METHODS: The 2005-2008 cycles of the National Health and Nutrition Examination Survey (NHANES) were queried for men who completed both a DM and a kidney/prostate questionnaire. Men with LUTS were defined as those experiencing at least 1 out of 3 of the following: nocturia, hesitancy, or incomplete emptying...
April 6, 2017: Urology
https://www.readbyqxmd.com/read/28391486/etiology-pathophysiology-and-biomarkers-of-interstitial-cystitis-painful-bladder-syndrome
#11
REVIEW
Sourav Sanchit Patnaik, Antonio Simone Laganà, Salvatore Giovanni Vitale, Salvatore Butticè, Marco Noventa, Salvatore Gizzo, Gaetano Valenti, Agnese Maria Chiara Rapisarda, Valentina Lucia La Rosa, Carlo Magno, Onofrio Triolo, Vani Dandolu
PURPOSE: Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic pain syndrome and a chronic inflammatory condition prevalent in women that leads to urgency, sleep disruption, nocturia and pain in the pelvic area, to the detriment of the sufferer's quality of life. The aim of this review is to highlight the newest diagnostic strategies and potential therapeutic techniques. METHODS: A comprehensive literature review was performed on MEDLINE, PubMed, and Cochrane databases gathering all literature about "Interstitial cystitis" and "Painful Bladder Syndrome"...
April 8, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28389939/cross-sectional-study-of-urinary-problems-in-adults-with-cerebral-palsy-awareness-and-impact-on-the-quality-of-life
#12
Necmettin Yıldız, Yeşim Akkoç, Murat Ersöz, Berrin Gündüz, Belgin Erhan, Hilal Yesil, Ayşe Nur Bardak, Senay Ozdolap, Hakan Tunç, Kurtulus Koklu, Ebru Alemdaroğlu, Ender Erden, Ulas Sungur, Ozlem Satır, Cagdaş Erdogan, Hakan Alkan
We aimed to assess the functional status, urinary problems, and awareness of these problems in adults with cerebral palsy (CP) and their relationship with the quality of life. One-hundred-seventeen adults with CP (53 women, 64 men) were included in this study. Subjects were asked to fill out a urological questionnaire which dealt with urinary symptoms, awareness of urinary problems, and pharmacological treatment they received. Subjects were also assessed with the Gross Motor Function Classification System (GMFCS), Functional Independence Measures (FIM), Functional Mobility Scale (FMS), and King's Health Questionnaire (KHQ)...
April 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28384655/fda-approval-of-desmopressin-for-nocturia
#13
Michael Fralick, Aaron S Kesselheim
No abstract text is available yet for this article.
April 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28383311/musculoskeletal-pain-profile-of-obese-individuals-attending-a-multidisciplinary-weight-management-service
#14
Grace A MacLellan, Colin Dunlevy, Emer O'Malley, Catherine Blake, Cathy Breen, Karen Gaynor, Natalie Wallace, Ruth Yoder, Domhnall Casey, John Mehegan, Donal O'Shea, Brona M Fullen
Obesity is associated with numerous chronic diseases, including musculoskeletal (MSK) pain, which impacts on quality of life (QoL). There is, however, limited research providing a comprehensive MSK pain profile of an obese cohort. This retrospective study utilized a patient database at a national weight management service (WMS). Following ethical approval, anonymized patient data were statistically analyzed to develop a pain profile, investigate relationships between pain, sleep, and function, and explore variables associated with having low back pain (LBP) and knee pain...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28370197/nocturia-treatment-outcomes-analysis-of-contributory-frequency-volume-chart-parameters
#15
Matthew Epstein, Jerry Blaivas, Alan J Wein, Jeffrey P Weiss
AIMS: Our aim is to determine which changes in frequency volume chart (FVC) parameters are associated with nocturia improvement. METHODS: This is a real life retrospective analysis of FVC's of men who were treated for nocturia and completed at least two 24 h FVC's. Patients were divided into two groups-an improved cohort defined by a decrease of ≥1 nocturnal void from baseline and a non-improved cohort. RESULTS: A total of 414 FVC's were analyzed (207 baseline and 207 post treatment) among a cohort of 105 men...
March 31, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28364461/double-blind-placebo-controlled-crossover-study-of-armodafinil-treatment-of-daytime-sleepiness-associated-with-treated-nocturia
#16
Andrew D Krystal, Xavier A Preud'homme
Study Objectives: Nocturia, voids which disturb sleep, is the most common cause of awakenings and is associated with daytime sleepiness. Because the standard treatments for the most common causes of nocturia are relatively ineffective, many treated patients with nocturia are left with residual sleepiness. We carried out this pilot study to evaluate the potential of armodafinil to be an effective means of addressing the sleepiness that persists in many nocturia patients, despite their receiving standard therapy...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28361203/physiotherapy-and-behavior-therapy-for-the-treatment-of-overactive-bladder-syndrome-a-prospective-cohort-study
#17
Martina Wolz-Beck, Christl Reisenauer, Giselle E Kolenic, Sabine Hahn, Sara Y Brucker, Markus Huebner
PURPOSE: To determine the efficacy of physiotherapy and behavior therapy and to find specific subgroups of women with overactive bladder syndrome that might gain increased benefit from this therapy. METHODS: Women with ≥10 micturitions per 24-h period were included. Six to nine therapy sessions were held within a 14-day interval. Efficacy end point was a reduction in micturitions and in episodes of nocturia. Secondary outcomes included ICIQ-OAB, ICIQ-OABqol and visual analog scales...
March 30, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28355584/ambulatory-urodynamic-monitoring-of-women-with-overactive-bladder-syndrome-during-single-voiding-cycle
#18
Fulya Dokmeci, S Esra Cetinkaya, M Murat Seval, Omer Dai
OBJECTIVE(S): To present data of standardized ambulatory urodynamic monitoring (AUM) performed in women with overactive bladder syndrome (OAB) and to evaluate the relevance of AUM data with clinical findings of the patients. STUDY DESIGN: Records of women with symptoms of OAB were retrospectively reviewed (n=249). Of women fulfilling the Overactive Bladder Awareness Tool (OAB-V8) with a score ≥8 and the 3-day voiding diary (VD) with a frequency >7/day (n=167), those who underwent urodynamic investigation were selected (n=76)...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28347292/protocol-for-a-randomized-double-blind-placebo-controlled-crossover-trial-of-melatonin-for-treatment-of-nocturia-in-adults-with-multiple-sclerosis-menims
#19
D Delgado, L Canham, N Cotterill, D Cottrell, M J Drake, K Inglis, D Owen, P White
BACKGROUND: Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect capacity to carry out daily activities. Melatonin is a natural hormone regulating circadian cycles, released by the pineal gland at night-time, and secretion is impaired in MS. Melatonin levels can be supplemented by administration in tablet form at bedtime. The aim of this study is to evaluate the effect of melatonin on mean number of nocturia episodes per night in MS patients...
March 27, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28345436/characterizing-health-care-utilization-direct-costs-and-comorbidities-associated-with-interstitial-cystitis-a-retrospective-claims-analysis
#20
Amy Tung, Zsolt Hepp, Aasthaa Bansal, Emily Beth Devine
BACKGROUND: Interstitial cystitis (IC) is a debilitating condition that affects up to 5% of the U.S. POPULATION: This condition is characterized by bladder pain, urinary urgency and frequency, nocturia, and, in some patients, bladder lesions called Hunner's lesions (HL). IC patients who have HL experience a clinical course that is distinct from those without HL and, as a result, respond differently to existing treatments. Without effective and lasting therapeutic options, IC patients are expected to experience a reduced quality of life and be a significant economic burden...
April 2017: Journal of Managed Care & Specialty Pharmacy
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