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https://www.readbyqxmd.com/read/27915481/effects-of-combination-treatment-of-alpha-1-adrenergic-receptor-antagonists-on-voiding-dysfunction-study-on-target-organs-in-overactive-bladder-rats
#1
Il Gyu Ko, Bo Min Moon, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Eun Sang Ji, Chang Ju Kim, Tai Hyung Kim, Hyun Hee Choi, Kyung Jin Chung
PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats. METHODS: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915472/pathomechanism-of-interstitial-cystitis-bladder-pain-syndrome-and-mapping-the-heterogeneity-of-disease
#2
REVIEW
Jia-Fong Jhang, Hann-Chorng Kuo
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a heterogeneous syndrome which is usually characterized by urinary frequency, nocturia, and bladder pain. Several pathomechanisms have been proposed, including uroepithelial dysfunction, mast cell activation, neurogenic inflammation, autoimmunity, and occult urinary tract infections. It is possible that an inflammatory process alters regulation of urothelial homeostasis and results in dysfunction of the bladder epithelium. Different phenotypes of IC/BPS have been explored including Hunner and non-Hunner type IC, hypersensitive bladder, and bladder pain both with and without functional somatic syndrome...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27905363/-sleep-disorders-in-the-early-stage-of-parkinson-s-disease-in-untreated-patients
#3
N A Amosova, I G Smolentseva, P M Guseinova, O A Maslyuk, E L Gavrilov
Disorders of sleep and wakefulness occur in about 60-98% of patients with Parkinson's disease (PD). The majority of research on the scale and nature of the disorders was performed in patients treated with antiparkinsonian drugs, and, therefore, the true picture of sleep disorders was interfering with side effects of therapy. The spectrum of these disorders in PD patients is broad and includes insomnia, parasomnia and hypersomnia. The main symptoms of insomnia are difficulty in maintaining sleep, associated with nocturia, rapid eye movement (REM) sleep behavior disorder (RBD), night cramps, akinesia and tremor...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904656/the-berlin-treatment-algorithm-recommendations-for-tailored-innovative-therapeutic-strategies-for-multiple-sclerosis-related-fatigue
#4
REVIEW
Christian Veauthier, Helge Hasselmann, Stefan M Gold, Friedemann Paul
More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed...
2016: EPMA Journal
https://www.readbyqxmd.com/read/27900215/drug-treatment-of-bothersome-lower-urinary-tract-symptoms-after-ureteric-jj-stent-insertion-a-contemporary-comparative-prospective-randomised-placebo-controlled-study-single-centre-experience
#5
Ihab A Hekal
OBJECTIVE: To provide a guide for medication to alleviate bothersome lower urinary tract symptoms (LUTS) in patients after JJ ureteric stenting. PATIENTS AND METHODS: Between June 2011 and June 2015, a prospective randomised placebo-controlled study was conducted on 200 consecutive cases of ureteric stones that required JJ stents. All patients had signed informed consent and JJ-stent placement confirmed by X-ray. The patients were randomised into five groups: A, solifenacin 5 mg; B, trospium chloride 20 mg; C, antispasmodic; and E, α-blocker; and a placebo group (D)...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27886073/effect-of-six-month-diet-intervention-on-sleep-among-overweight-and-obese-men-with-chronic-insomnia-symptoms-a-randomized-controlled-trial
#6
Xiao Tan, Markku Alén, Kun Wang, Jarkko Tenhunen, Petri Wiklund, Markku Partinen, Sulin Cheng
Growing evidence suggests that diet alteration affects sleep, but this has not yet been studied in adults with insomnia symptoms. We aimed to determine the effect of a six-month diet intervention on sleep among overweight and obese (Body mass index, BMI ≥ 25 kg/m²) men with chronic insomnia symptoms. Forty-nine men aged 30-65 years with chronic insomnia symptoms were randomized into diet (n = 28) or control (n = 21) groups. The diet group underwent a six-month individualized diet intervention with three face-to-face counseling sessions and online supervision 1-3 times per week; 300-500 kcal/day less energy intake and optimized nutrient composition were recommended...
November 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27869312/the-effect-of-emg-biofeedback-assisted-pelvic-floor-muscle-therapy-on-symptoms-of-the-overactive-bladder-syndrome-in-women-a-randomized-controlled-trial
#7
Jeroen C Voorham, Stefan De Wachter, Tine W L Van den Bos, Hein Putter, Guus A Lycklama À Nijeholt, Petra J Voorham-van der Zalm
AIMS: The overactive bladder syndrome (OAB) is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Biofeedback-assisted pelvic muscle therapy (BAPFMT) is a first-line treatment option for OAB. The aims of this study were to determine the efficacy and effectiveness of BAPFMT on symptoms of OAB after 9 weeks of treatment and to detect changes EMG activity of individual pelvic floor muscles (PFM) with the MAPLe. METHODS: Patients were randomly divided into an intervention group that received BAPFMT with the MAPLe or into a control group which received only toilet behavior and lifestyle instructions...
November 21, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27865145/rectal-gastrointestinal-stromal-tumor-with-metastasis-to-the-penis-case-report-and-review-of-literature
#8
Jacob Carlson, Wilson Alobuia, Jason Mizell
We report the case of a 51-year-old gentleman with previously diagnosed gastrointestinal stromal tumor (GIST) of the rectum with metastasis to the penis. The patient underwent abdominoperineal resection of the primary tumor with negative margins and completed a three-year course of imatinib mesylate (Gleevec). Forty months after resection of his rectal tumor, the patient presented to his urologist with worsening testicular pain, mild lower urinary tract obstructive symptoms, and nocturia. A pelvic MRI revealed the presence of an ill-defined mass in the right perineum extending from the base of the penis to the penoscrotal junction...
November 9, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27863901/a-systematic-review-of-the-literature-on-disorders-of-sleep-and-wakefulness-in-parkinson-s-disease-from-2005-to-2015
#9
REVIEW
Lama M Chahine, Amy W Amara, Aleksandar Videnovic
Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders...
August 31, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27862898/low-dose-desmopressin-combined-with-serum-sodium-monitoring-can-prevent-clinically-significant-hyponatraemia-in-patients-treated-for-nocturia
#10
Kristian Vinter Juul, Anders Malmberg, Egbert van der Meulen, Johan Vande Walle, Jens Peter Nørgaard
OBJECTIVE: To explore risk factors for desmopressin-induced hyponatraemia and evaluate the impact of a serum sodium monitoring plan. SUBJECTS AND METHODS: This was a meta-analysis of data from three clinical trials of desmopressin in nocturia. Participants received placebo or desmopressin orally disintegrating tablet ([ODT], 10-100 μg). Incidence of serum sodium <130 mmol/L was recorded by age, sex and dose. Potential predictors of clinically significant hyponatraemia were identified using multivariate analysis in a Cox proportional hazards model...
November 15, 2016: BJU International
https://www.readbyqxmd.com/read/27845120/re-incidence-and-remission-of-nocturia-a-systematic-review-and-meta-analysis
#11
Tomas L Griebling
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27845118/re-effects-of-a-gentle-self-administered-stimulation-of-perineal-skin-for-nocturia-in-elderly-women-a-randomized-placebo-controlled-double-blind-crossover-trial
#12
https://www.readbyqxmd.com/read/27843276/new-visual-prostate-symptom-score-versus-international-prostate-symptom-score-in-men-with-lower-urinary-tract-symptoms-a-prospective-comparision-in-indian-rural-population
#13
Ashutosh Roy, Amandeep Singh, Darshan Singh Sidhu, R P Jindal, Mishi Malhotra, Haramritpal Kaur
INTRODUCTION: Benign prostrate hyperplasia (BPH) is a leading source of healthcare problem in aging men around the world including India. Both International Prostate Symptom Score (IPSS) and New Visual Prostate Symptom Score (VPSS) are used to assess the lower urinary tracts symptoms (LUTSs) in men. The present study was planned to compare these two scores, IPSS and VPSS in Indian rural men prospectively and their efficacy was compared with urodynamic evaluation of the patients. MATERIALS AND METHODS: With Institutional Ethical Committee approval, this study was conducted on 100 patients having LUTS and BPH after obtaining written informed consent...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27819752/a-prospective-randomized-controlled-multicentre-trial-comparing-intravesical-dmso-and-chondro%C3%A3-tin-sulphate-2-for-painful-bladder-syndrome-interstitial-cystitis
#14
Manuela Tutolo, Enrico Ammirati, Giulia Castagna, Katrien Klockaerts, Hendrik Plancke, Dieter Ost, Frank Van der Aa, Dirk De Ridder
OBJECTIVE: To compare effectiveness of intravesical chondroïtin sulphate (CS) 2% and dimethyl sulphoxide (DMSO) 50% in patients with painful bladder syndrome/intersti¬tial cystitis (PBS/IC). MATERIALS AND METHODS: Patients were randomized to receive either 6 weekly instil¬lations of CS 2% or 50% DMSO. Primary endpoint was difference in proportion of patients achieving score 6 (moderately improved) or 7 (markedly improved) in both groups using the Global Response Assessment (GRA) scale...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27816615/nocturnal-urinary-disorders-in-multiple-sclerosis-clinical-and-urodynamic-study-of-309-patients
#15
Elsa Mauruc, Amandine Guinet-Lacoste, Lætitia Falcou, Philippe Manceau, Delphine Verollet, Frédérique Le Breton, Gérard Amarenco
PURPOSE: The aim of this study was to describe nocturia with or without leakage in a population of patients with multiple sclerosis. MATERIALS AND METHODS: This is a retrospective, single center study of 309 patients with multiple sclerosis who were followed at an experienced neurourology center between 2011 and 2013. All patients had daytime urinary symptoms associated with this disorder. Among the patients with nocturia 2 groups were defined, including those with isolated nocturia but without nocturnal urinary incontinence and patients with nocturia associated with nocturnal urinary incontinence...
November 2, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27805334/nocturia-symptom-or-a-disease
#16
REVIEW
Vyas Narayana Rao, Ganesh Gopalakrishnan, Ajit Saxena, Hemant Pathak, Divakar Dalela, Shailesh Shah, Mallikarjuna Reddy, Prasanna Kumar Mishra, Harshad Malve
Waking at night to void is known as nocturia and it is a common condition experienced by both men and women with profound impact on patient's health, quality of life, and economic condition. It is often perceived as a symptom of an organic disease, but the pathophysiology of nocturia is now well-understood, and it is considered as a disease itself. It is classified based on four different pathophysiologic mechanisms (24-hour polyuria, nocturnal polyuria, reduced bladder capacity, and sleep disorders). The association of nocturia with impaired quality of life, cardiovascular morbidity and all-cause mortality is well established...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27802008/percutaneous-tibial-nerve-stimulation-versus-electrical-stimulation-with-pelvic-floor-muscle-training-for-overactive-bladder-syndrome-in-women-results-of-a-randomized-controlled-study
#17
Carlo Vecchioli Scaldazza, Carolina Morosetti, Rosita Giampieretti, Rossana Lorenzetti, Marinella Baroni
INTRODUCTION: This study compared percutaneous tibial nerve stimulation (PTNS) versus electrical stimulation with pelvic floor muscle training (ES + PFMT) in women with overactive bladder syndrome (OAB). MATERIALS AND METHODS: 60 women with OAB were enrolled. Patients were randomized into two groups. In group A, women underwent ES with PFMT, in group B women underwent PTNS. RESULTS: A statistically significant reduction in the number of daily micturitions, episo¬des of nocturia and urge incontinence was found in the two groups but the difference was more substantial in women treated with PTNS; voided volume increased in both groups...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27799752/nocturia-a-bothersome-urological-symptom-in-the-elderly
#18
Bahram Shekarchi, Mohammad Zamani
No abstract text is available yet for this article.
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27794164/the-association-between-the-iciq-luts-and-the-iciq-bladder-diary-in-assessing-luts
#19
Haitham Abdelmoteleb, Mohamed I Kamel, Hashim Hashim
OBJECTIVES: The bladder diary (BD) provides a non-invasive method of investigating lower urinary tract symptoms (LUTS) while the International Consultation on Incontinence Questionnaires (ICIQ) symptom questionnaires, such as the ICIQ-MLUTS and ICIQ-FLUTS for males and females, respectively, provide a subjective assessment. The association between objective and subjective assessments has not been well established for the ICIQ. MATERIALS AND METHODS: Retrospective analysis of data collected from a urodynamics database was conducted...
October 29, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27787187/overactive-bladder-in-women
#20
Julie C Jenks
Overactive bladder in women is a common chronic condition of urinary storage, affecting a significant proportion of the population. It is defined as a symptom diagnosis that indicates lower urinary tract dysfunction, in which patients experience urinary urgency, with or without urge incontinence, usually accompanied by frequency and nocturia. The diagnosis and treatment of overactive bladder are straightforward and systematic in line with national and international guidelines. However, women are required to disclose their bladder symptoms, and be motivated to make changes to their lifestyle to see improvements...
October 26, 2016: Nursing Standard
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