Esther Martin de Fourchambault, Nathalie Callens, Jean-Michel Saliou, Marie Fourcot, Oceane Delos, Nicolas Barois, Quentin Thorel, Santseharay Ramirez, Jens Bukh, Laurence Cocquerel, Justine Bertrand-Michel, Guillemette Marot, Yasmine Sebti, Jean Dubuisson, Yves Rouillé
Despite the introduction of effective treatments for hepatitis C in clinics, issues remain regarding the liver disease induced by chronic hepatitis C virus (HCV) infection. HCV is known to disturb the metabolism of infected cells, especially lipid metabolism and redox balance, but the mechanisms leading to HCV-induced pathogenesis are still poorly understood. In an APEX2-based proximity biotinylation screen, we identified ACBD5, a peroxisome membrane protein, as located in the vicinity of HCV replication complexes...
2023: Frontiers in Microbiology