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Psychology and meth

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https://www.readbyqxmd.com/read/27799294/structure-activity-relationships-of-substituted-cathinones-with-transporter-binding-uptake-and-release
#1
Amy J Eshleman, Katherine M Wolfrum, John F Reed, Sunyoung O Kim, Tracy Swanson, Robert A Johnson, Aaron J Janowsky
Synthetic cathinones are components of "bath salts" and have physical and psychological side effects including hypertension, paranoia, and hallucinations. Herein we report interactions of 20 "bath salt" components with human dopamine, serotonin, and norepinephrine transporters (hDAT, hSERT, and hNET, respectively) heterologously expressed in HEK 293 cells. Transporter inhibitors had nanomolar to micromolar affinities (Ki values) at radioligand binding sites, with relative affinities of hDAT>hNET>hSERT for α-PPP, α-PBP, α-PHP, PV-8, 3,4-MDPPP, 3,4-MDPBP, 4-MePPP, α-PVP, 4-MeO- α-PVP, α-PVT and pentedrone, and hDAT>hSERT>hNET for pentylone...
October 31, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27746146/methamphetamine-induced-toxicity-the-role-of-autophagy
#2
Ali Roohbakhsh, Kobra Shirani, Gholamreza Karimi
Methamphetamine (METH) is a highly potent and addictive drug with major medical, psychiatric, cognitive, socioeconomic, and legal consequences. It is well absorbed following different routes of administration and distributed throughout the body. METH is known as psychomotor stimulant with potent physiological outcomes on peripheral and central nervous systems, resulting in physical and psychological disorders. Autophagy is a highly conserved and regulated catabolic pathway which is critical for maintaining cellular energy homeostasis and regulating cell growth...
October 13, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27541988/psychological-burden-and-gender-differences-in-methamphetamine-dependent-individuals-in-treatment
#3
Jamie L Simpson, Kathleen M Grant, Patrick M Daly, Stephanie G Kelley, Gustavo Carlo, Rick A Bevins
BACKGROUND AND OBJECTIVES: Little is known about gender differences in methamphetamine (METH)-dependent users. The objective of this study was to examine potential gender differences in four domains: drug use history, psychological burden, current symptomology, and coping strategy. METHODS: One hundred twenty four METH-dependent individuals (men; n = 75) were enrolled from substance use treatment programs. Participants filled out detailed questionnaires in the four domains...
September 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/26953131/methamphetamine-compromises-gap-junctional-communication-in-astrocytes-and-neurons
#4
Paul Castellano, Chisom Nwagbo, Luis R Martinez, Eliseo A Eugenin
Methamphetamine (meth) is a central nervous system (CNS) stimulant that results in psychological and physical dependency. The long-term effects of meth within the CNS include neuronal plasticity changes, blood-brain barrier compromise, inflammation, electrical dysfunction, neuronal/glial toxicity, and an increased risk to infectious diseases including HIV. Most of the reported meth effects in the CNS are related to dysregulation of chemical synapses by altering the release and uptake of neurotransmitters, especially dopamine, norepinephrine, and epinephrine...
May 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/26689233/a-qualitative-exploration-of-perceived-gender-differences-in-methamphetamine-use-among-women-who-use-methamphetamine-on-the-mexico-u-s-border
#5
Oralia Loza, Rebeca Ramos, João Ferreira-Pinto, Maria Teresa Hernandez, Susana A Villalobos
The purpose of this study is to extend the research on contextual factors that influence the initiation and continued use of methamphetamine (meth) by women on the U.S.-Mexico border. At present, a minimal body of literature exists that explores meth use on the Mexico-U.S. border. A purposeful sample of 20 women who were active meth users aged ≥18 years was recruited by trained outreach workers from a variety of meth-user networks in Ciudad Juárez, Mexico, the city bordering El Paso, Texas. Respondents participated in in-depth, semi-structured interviews including questions on users' perceived familial, social, and environmental influences of meth use...
December 21, 2015: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/26612552/the-effects-of-4-methylethcathinone-on-conditioned-place-preference-locomotor-sensitization-and-anxiety-like-behavior-a-comparison-with-methamphetamine
#6
Peng Xu, Yi Qiu, Yizhi Zhang, Yanping Βai, Pengfei Xu, Yuan Liu, Jee Hyun Kim, Hao-wei Shen
BACKGROUND: 4-Methylethcathinone is a drug that belongs to the second generation of synthetic cathinones, and recently it has been ranked among the most popular "legal highs". Although it has similar in vitro neurochemical actions to other drugs such as cocaine, the behavioral effects of 4-methylethcathinone remain to be determined. METHODS: The addictive potential and locomotor potentiation by 4-methylethcathinone were investigated in rats using the conditioned place preference and sensitization paradigm...
April 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26519763/childhood-trauma-and-meth-abuse-among-men-who-have-sex-with-men-implications-for-intervention
#7
Maria Lopez-Patton, Mahendra Kumar, Deborah Jones, Marla Fonseca, Adarsh M Kumar, Charles B Nemeroff
Methamphetamine (METH) has become one of the most widely abused drugs in South Florida, particularly among MSM who may or may not be HIV seropositive. High rates of childhood trauma have been reported among HIV-infected MSM (Chartier et al., 2010), but, the association of childhood trauma, and mood disorders with methamphetamine use in HIV-infected men, has not been comprehensively explored. A better understanding of the association between these factors could improve existing substance abuse treatment intervention strategies and medical treatment programs (e...
January 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/25813709/comparison-of-noradrenaline-dopamine-and-serotonin-in-mediating-the-tachycardic-and-thermogenic-effects-of-methamphetamine-in-the-ventral-medial-prefrontal-cortex
#8
S F Hassan, S Zumut, P G Burke, S McMullan, J L Cornish, A K Goodchild
Methamphetamine (METH) is a psychostimulant that disrupts monoaminergic neurotransmission to evoke profound behavioral and physiological effects. Rapidly distributing to forebrain regions to increase synaptic concentrations of three monoamines (dopamine (DA), serotonin (5-HT) and noradrenaline (NA)), the medial prefrontal cortex (mPFC) is important in METH-altered behavioral and psychological profiles. Activation of the ventral mPFC can modify physiological variables, however, METH-evoked autonomic changes from this region are unknown...
June 4, 2015: Neuroscience
https://www.readbyqxmd.com/read/25459292/effect-of-the-environmental-enrichment-on-the-severity-of-psychological-dependence-and-voluntary-methamphetamine-consumption-in-methamphetamine-withdrawn-rats
#9
Samira Hajheidari, Hossein Miladi-Gorji, Imanollah Bigdeli
Previously results have been shown that chronic methamphetamine causes dependence, withdrawal syndrome and drug craving. Also, environmental enrichment (EE) has been shown protective effects in several animal models of addiction. This study evaluated effect of the EE on the anxiety-depression profile and voluntary METH consumption in METH-dependent rats after abstinence. The rats were chronically treated with bi-daily doses (2 mg/kg, at 12 h intervals) of METH over a period of 14 days. METH dependent rats reared in standard environment (SE) or EE during spontaneous METH withdrawal which lasted 30 days...
January 1, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/24569009/the-role-of-the-laterodorsal-tegmental-nucleus-in-methamphetamine-conditioned-place-preference-and-locomotor-activity
#10
Lauren K Dobbs, Christopher L Cunningham
Methamphetamine (METH) indirectly stimulates the laterodorsal tegmental nucleus (LDT) acetylcholine (ACh) neurons to increase ACh within the ventral tegmental area (VTA). LDT ACh inhibition attenuates METH and saline locomotor activity. The aim of these experiments was to determine whether LDT ACh contributes to METH conditioned place preference (CPP). C57BL/6J mice received a bilateral electrolytic or sham lesion of the LDT. After recovery, mice received alternating pairings of METH (0.5 mg/kg) and saline with distinct tactile floor cues over 8 days...
May 15, 2014: Behavioural Brain Research
https://www.readbyqxmd.com/read/24150570/changes-in-neural-circuitry-regulating-response-reversal-learning-and-arc-mediated-consolidation-of-learning-in-rats-with-methamphetamine-induced-partial-monoamine-loss
#11
Elissa D Pastuzyn, Kristen A Keefe
Methamphetamine (METH)-induced neurotoxicity results in long-lasting depletions of monoamines and changes in basal ganglia function. We previously reported that rats with METH-induced neurotoxicity no longer engage dorsomedial striatum during a response-reversal learning task, as their performance is insensitive to acute disruption of dorsomedial striatal function by local infusion of an N-methyl-D-aspartate receptor antagonist or an antisense oligonucleotide against the activity-regulated cytoskeleton-associated (Arc) gene...
March 2014: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/24012327/selective-retrieval-independent-disruption-of-methamphetamine-associated-memory-by-actin-depolymerization
#12
Erica J Young, Massimiliano Aceti, Erica M Griggs, Rita A Fuchs, Zachary Zigmond, Gavin Rumbaugh, Courtney A Miller
BACKGROUND: Memories associated with drugs of abuse, such as methamphetamine (METH), increase relapse vulnerability to substance use disorder. There is a growing consensus that memory is supported by structural and functional plasticity driven by F-actin polymerization in postsynaptic dendritic spines at excitatory synapses. However, the mechanisms responsible for the long-term maintenance of memories, after consolidation has occurred, are largely unknown. METHODS: Conditioned place preference (n = 112) and context-induced reinstatement of self-administration (n = 19) were used to assess the role of F-actin polymerization and myosin II, a molecular motor that drives memory-promoting dendritic spine actin polymerization, in the maintenance of METH-associated memories and related structural plasticity...
January 15, 2014: Biological Psychiatry
https://www.readbyqxmd.com/read/24012068/dynamic-indices-of-methamphetamine-dependence-and-hiv-infection-predict-fluctuations-in-affective-distress-a-five-year-longitudinal-analysis
#13
Jessica L Montoya, Anya Umlauf, Ian Abramson, Jayraan Badiee, Steven Paul Woods, J Hampton Atkinson, Igor Grant, David J Moore
BACKGROUND: Methamphetamine (METH) use and human immunodeficiency virus (HIV) infection are highly comorbid, and both are associated with increased prevalence of affective distress. Delineating the trajectory of affective distress in the context of METH dependence and HIV infection is important given the implications for everyday functional impairment, adverse health behaviors, and increased risk for adverse health outcomes. METHODS: We conducted a five-year longitudinal investigation involving 133 METH-dependent (74 HIV seropositive) and 163 non-METH-dependent (90 HIV seropositive) persons to examine both long-standing patterns and transient changes in affective distress...
November 2013: Journal of Affective Disorders
https://www.readbyqxmd.com/read/23995583/dysregulation-of-dopamine-and-glutamate-release-in-the-prefrontal-cortex-and-nucleus-accumbens-following-methamphetamine-self-administration-and-during-reinstatement-in-rats
#14
Aram Parsegian, Ronald E See
Methamphetamine (meth) addicts often exhibit enduring cognitive and neural deficits that likely contribute to persistent drug seeking and the high rates of relapse. These deficits may be related to changes in the prefrontal cortex (PFC) and its glutamatergic projections to the nucleus accumbens (NAc). Here, we performed in vivo microdialysis in the PFC and NAc in rats following either meth self-administration or yoked-saline control histories to assess baseline glutamate (GLU) levels, or reinstatement-evoked GLU and dopamine (DA) efflux in both regions simultaneously under cue-induced, meth-primed, or combined cues+meth reinstatement conditions...
March 2014: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/23953128/spatial-memory-and-animal-movement
#15
William F Fagan, Mark A Lewis, Marie Auger-Méthé, Tal Avgar, Simon Benhamou, Greg Breed, Lara LaDage, Ulrike E Schlägel, Wen-wu Tang, Yannis P Papastamatiou, James Forester, Thomas Mueller
Memory is critical to understanding animal movement but has proven challenging to study. Advances in animal tracking technology, theoretical movement models and cognitive sciences have facilitated research in each of these fields, but also created a need for synthetic examination of the linkages between memory and animal movement. Here, we draw together research from several disciplines to understand the relationship between animal memory and movement processes. First, we frame the problem in terms of the characteristics, costs and benefits of memory as outlined in psychology and neuroscience...
October 2013: Ecology Letters
https://www.readbyqxmd.com/read/23861896/the-metabotropic-glutamate-5-receptor-modulates-extinction-and-reinstatement-of-methamphetamine-seeking-in-mice
#16
Rose Chesworth, Robyn M Brown, Jee Hyun Kim, Andrew J Lawrence
Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction. We sought to assess the involvement of the metabotropic glutamate 5 receptor (mGlu5) in behaviours relevant to METH addiction because this receptor has been implicated in the actions of other drugs of abuse, including alcohol, cocaine and opiates. mGlu5 knockout (KO) mice were tested in intravenous self-administration, conditioned place preference and locomotor sensitization...
2013: PloS One
https://www.readbyqxmd.com/read/23764194/sex-differences-in-methamphetamine-seeking-in-rats-impact-of-oxytocin
#17
Brittney M Cox, Amy B Young, Ronald E See, Carmela M Reichel
Previous evidence in an animal model of drug self-administration and drug seeking showed that acute oxytocin decreased methamphetamine (meth) seeking in male rats, suggesting potential clinical efficacy for the treatment of psychostimulant addiction. However, based on the well-established role of oxytocin in reproduction and pair bond formation, it is important to know how this effect extrapolates to females. Here, we tested whether oxytocin (1mg/kg, IP) would decrease meth seeking in female rats across various stages of the estrous cycle (Experiment 1)...
October 2013: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/23711566/roles-of-levo-tetrahydropalmatine-in-modulating-methamphetamine-reward-behavior
#18
Hong-Liang Su, Jie Zhu, Yan-Jiong Chen, Na Zhao, Wei Han, Yong-Hui Dang, Ming Xu, Teng Chen
Levo-tetrahydropalmatine (l-THP), as an alkaloid purified from the traditional Chinese herbal medicine Corydalis and Stephania, has been widely used to produce many traditional Chinese herbal preparations. The effect of l-THP on methamphetamine-induced reward learning still remains unclear although it has been proved to be effective on treating allodynia and drug addiction. This experiment has been designed to examine the effect of l-THP on the acquisition, expression, extinction, and reinstatement of methamphetamine-induced conditioned place preference (CPP) in mice...
June 13, 2013: Physiology & Behavior
https://www.readbyqxmd.com/read/23685547/response-of-neurotensin-basal-ganglia-systems-during-extinction-of-methamphetamine-self-administration-in-rat
#19
Glen R Hanson, Amanda J Hoonakker, Christina M Robson, Lisa M McFadden, Paul S Frankel, Mario E Alburges
Because of persistent social problems caused by methamphetamine (METH), new therapeutic strategies need to be developed. Thus, we investigated the response of central nervous system neurotensin (NT) systems to METH self-administration (SA) and their interaction with basal ganglia dopamine (DA) pathways. Neurotensin is a peptide associated with inhibitory feedback pathways to nigrostriatal DA projections. We observed that NT levels decreased in rats during extinction of METH SA when lever pressing resulted in intravenous infusions of saline rather than METH...
August 2013: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/23643743/cyclooxygenase-activity-contributes-to-the-monoaminergic-damage-caused-by-serial-exposure-to-stress-and-methamphetamine
#20
Nicole A Northrop, Bryan K Yamamoto
Methamphetamine (Meth) is a widely abused psychostimulant that causes long-term dopamine (DA) and serotonin (5-HT) depletions. Stress and Meth abuse are comorbid events in society and stress exacerbates Meth-induced monoaminergic terminal damage. Stress is also known to produce neuroinflammation. This study examined the role of the neuroinflammatory mediator, cyclooxygenase (COX), in the depletions of monoamines caused by serial exposure to chronic unpredictable stress (CUS) and Meth. CUS produced an increase in COX-2 protein expression and enhanced Meth-induced monoaminergic depletions in the striatum and hippocampus...
September 2013: Neuropharmacology
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