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https://www.readbyqxmd.com/read/28332729/transplantation-of-kidneys-from-hepatitis-c-positive-donors-into-hepatitis-c-virus-infected-recipients-followed-by-early-initiation-of-direct-acting-antiviral-therapy-a-single-center-retrospective-study
#1
Kalyan Ram Bhamidimarri, Marco Ladino, Fernando Pedraza, Giselle Guerra, Adela Mattiazzi, Linda Chen, Gaetano Ciancio, Warren Kupin, Paul Martin, George Burke, David Roth
The availability of direct acting antiviral agents (DAA) has transformed the treatment of hepatitis C virus (HCV) infection. The current study is a case series that reports the outcomes from a cohort of twenty-five HCV-infected ESRD patients who received a kidney from an anti-HCV-positive deceased organ donor followed by treatment with DAAs in the early post-transplant period. Time to transplantation and the efficacy of DAA therapy as measured by sustained viral response at 12 weeks were assessed. The median waiting time from original date of activation on the UNOS waiting list until transplantation was 427 days, however, the median time from entering the patient into UNet(sm) for a HCV positive offer until transplantation was only 58 days...
March 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28332370/the-need-for-new-donor-stratification-to-predict-graft-survival-in-deceased-donor-kidney-transplantation
#2
Shin Seok Yang, Jaeseok Yang, Curie Ahn, Sang Il Min, Jongwon Ha, Sung Joo Kim, Jae Berm Park
PURPOSE: The aim of this study was to determine whether stratification of deceased donors by the United Network for Organ Sharing (UNOS) criteria negatively impacts graft survival. MATERIALS AND METHODS: We retrospectively reviewed deceased donor and recipient pretransplant variables of kidney transplantations that occurred between February 1995 and December 2009. We compared clinical outcomes between standard criteria donors (SCDs) and expanded criteria donors (ECDs)...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28323751/long-term-nitrite-inhalant-exposure-and-cancer-risk-in-men-who-have-sex-with-men-a-prospective-cohort-study
#3
Anupriya Dutta, Hajime Uno, Alex Holman, David R Lorenz, Steven M Wolinsky, Dana Gabuzda
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among men who have sex with men (MSM) and were previously associated with elevated rates of high-risk sexual behavior, HIV and HHV-8 seroconversion, and transient immunosuppressive effects in experimental models. Whether long-term popper use is associated with cancer risk among MSM in the HAART era is unclear. DESIGN: Prospective cohort study of cancer risk in 3223 HIV-infected and -uninfected MSM in the Multicenter AIDS Cohort Study from 1996-2010...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28322526/-bere-problematico-e-problemi-di-salute-in-toscana-e-in-friuli-venezia-giulia-uno-studio-epidemiologico-attraverso-i-medici-di-medicina-generale
#4
Allaman Allamani, Stefano Bravi, Pasquale Pepe, Fabio Voller, Francesco Marcatto, Donatella Ferrante, Jakob Manthey, Jürgen Rehm, Pierluigi Struzzo
"OBJECTIVES: to identify the differences among patients of general practictioners (GPs) in both Tuscany Region (Central Italy) and Friuli Venezia Giulia (FVG) Region (Northern Italy), which are different for drinking cultures, as to motivation of consultation, hazardous drinking and alcohol dependence, health problems, and use of health services. DESIGN: cross-sectional study by means of both a medical examination and a subsequent structured interview carried out with a questionnaire...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28319566/pancreas-transplantation-from-pediatric-donors-a-unos-registry-analysis
#5
Mario Spaggiari, Martha Bissing, Maya Campara, Chun-Chieh Yeh, Ivo Tzvetanov, Hoonbae Jeon, Enrico Benedetti
BACKGROUND: Pancreas grafts from pediatric donors are still considered "not ideal". Perceived concerns are related to low islet mass and potential for graft thrombosis. METHODS: The study evaluated all pancreas transplants from January 2000 to May 2015 using the Organ Procurement and Transplant Network (OPTN) database. Comparative analysis of recipient and graft survival was performed between pediatric (≤18 years) and adult donors. In the pediatric group, the outcomes were stratified based on donor age (≤ 6 years; 7-12 years; 13-18 years) and weight (<30 kg; 30-95 Kg; >95 kg)...
March 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28319198/methamphetamine-induces-shati-nat8l-expression-in-the-mouse-nucleus-accumbens-via-creb-and-dopamine-d1-receptor-dependent-mechanism
#6
Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta
Shati/Nat8L significantly increased in the nucleus accumbens (NAc) of mice after repeated methamphetamine (METH) treatment. We reported that Shati/Nat8L overexpression in mouse NAc attenuated METH-induced hyperlocomotion, locomotor sensitization, and conditioned place preference. We recently found that Shati/Nat8L overexpression in NAc regulates the dopaminergic neuronal system via the activation of group II mGluRs by elevated N-acetylaspartylglutamate following N-acetylaspartate increase due to the overexpression...
2017: PloS One
https://www.readbyqxmd.com/read/28318883/predicting-future-risk-of-exacerbations-in-japanese-patients-with-adult-asthma-a-prospective-1-year-follow-up-study
#7
Akihiko Tanaka, Tomoki Uno, Haruna Sato, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Munehiro Yamaguchi, Shin Ohta, Tetsuya Homma, Mayumi Yamamoto, Shintaro Suzuki, Takuya Yokoe, Hironori Sagara
BACKGROUND: To avoid future risk is a definitive goal of long-term asthma management. Exacerbations are considered to be the most relevant future risk in real life asthma management. Few comparative studies have evaluated the risk factors associated with exacerbations in Japanese patients with asthma. METHODS: We performed the prospective 1-year follow up study in Japanese patients with adult asthma. A total of 189 patients with asthma were enrolled and followed up for 1 year...
March 16, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28299628/management-of-colon-stents-based-on-bernoulli-s-principle
#8
Yoshiharu Uno
BACKGROUND AND AIMS: The colonic self-expanding metal stent (SEMS) has been widely used for "bridge to surgery" and palliative therapy. However, if the spread of SEMS is insufficient, not only can a decompression effect not be obtained but also perforation and obstructive colitis can occur. The mechanism of occurrence of obstructive colitis and perforation was investigated by flow dynamics. METHODS: Bernoulli's principle was applied, assuming that the cause of inflammation and perforation represented the pressure difference in the proximal lumen and stent...
March 16, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28296808/waitlisted-candidates-with-polycystic-liver-disease-are-more-likely-to-be-transplanted-than-those-with-chronic-liver-failure
#9
Sahil D Doshi, Therese Bittermann, Thomas D Schiano, David Seth Goldberg
BACKGROUND: Polycystic liver disease (PCLD) is characterized by cystic replacement of the hepatic parenchyma, leading to hepatic dysfunction, portal hypertension, and hepatomegaly. Patients with liver dysfunction and/or symptomatic disease are eligible for liver transplantation. However, little is known about these patients' waitlist outcomes relative to others with chronic liver disease. METHODS: We used OPTN/UNOS data from February 27, 2002 to December 31, 2015 to compare waitlist outcomes of adult patients with PCLD to those with chronic liver failure (CLF) and hepatocellular carcinoma (HCC)...
March 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28295652/long-term-survival-following-kidney-transplantation-in-previous-lung-transplant-recipients-an-analysis-of-the-unos-registry
#10
Asishana A Osho, Sameer A Hirji, Anthony W Castleberry, Michael S Mulvihill, Asvin M Ganapathi, Paul J Speicher, Babatunde Yerokun, Laurie D Snyder, Robert D Davis, Mathew G Hartwig
BACKGROUND: Kidney transplantation has been advocated as a therapeutic option in lung recipients who develop end-stage renal disease. This analysis outlines patterns of allograft survival following kidney transplantation in previous lung recipients (KAL). METHODS: Data from the UNOS lung and kidney transplantation registries (1987-2013) were cross-linked to identify lung recipients who were subsequently listed for and/or underwent kidney transplantation. Time-dependent Cox models compared survival in KAL patients vs...
March 10, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28289566/differential-attraction-of-drosophilids-to-banana-baits-inoculated-with-saccharomyces-cerevisiae-and-hanseniaspora-uvarum-within-a-neotropical-forest-remnant
#11
Marcos R D Batista, Fabiana Uno, Rafael D Chaves, Rosana Tidon, Carlos A Rosa, Louis B Klaczko
BACKGROUND: Yeasts are a necessary requisite in the diet of most Drosophila species that, in turn, may vector their dispersal in natural environments. Differential attractiveness experiments and the isolation of yeasts consumed by Drosophila may be informative for characterizing this association. Hanseniaspora uvarum is among the most common yeast species isolated from Drosophila crops, with high attractiveness to drosophilids. Saccharomyces cerevisiae has been widely used to collect flies, and it allows broad sampling of almost all local Drosophila species...
2017: PeerJ
https://www.readbyqxmd.com/read/28283801/serum-amyloid-a1-is-upregulated-in-human-glioblastoma
#12
Franciele Hinterholz Knebel, Miyuki Uno, Thais F Galatro, Luziane Potrich Bellé, Sueli Mieko Oba-Shinjo, Suely Kazue N Marie, Ana Campa
Serum amyloid A1 (SAA1) is a sensitive acute phase reactant primarily produced by the liver in response to acute inflammation. We have recently shown that SAA affects proliferation, migration, and invasion of glioblastoma cell lines, which suggest its participation in the malignant process. Consistently, levels of SAA have been used as a non-invasive biomarker for the prognosis of many cancers. In this study, we aimed to investigate SAA serum levels and expression of SAA genes in human astrocytomas tissues...
March 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28279847/discovery-of-novel-furanone-derivatives-as-potent-cdc7-kinase-inhibitors
#13
Takayuki Irie, Tokiko Asami, Ayako Sawa, Yuko Uno, Mitsuharu Hanada, Chika Taniyama, Yoko Funakoshi, Hisao Masai, Masaaki Sawa
Cdc7 is a serine-threonine kinase and plays a conserved and important role in DNA replication, and it has been recognized as a potential anticancer target. Herein, we report the design, synthesis and structure-activity relationship of novel furanone derivatives as Cdc7 kinase inhibitors. Compound 13 was identified as a strong inhibitor of Cdc7 with an IC50 value of 0.6 nM in the presence of 1 mM ATP and showed excellent kinase selectivity. In addition, it exhibited slow off-rate characteristics, which may offer advantages over known Cdc7 inhibitors in its potential to yield prolonged inhibitory effects in vivo...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28270320/distributions-of-nitrated-polycyclic-aromatic-hydrocarbons-in-the-sediment-of-osaka-bay-japan
#14
Seiichi Uno, Hiroyuki Tanaka, Emiko Kokushi, Eugene T Bacolod, Jiro Koyama
The distributions of 15 nitrated polycyclic aromatic hydrocarbons (NPAHs) in sediments collected at 44 sites throughout Osaka Bay, Japan were examined. The highest total NPAHs, with a concentration of 1949ng/kg dry weight, were detected near the city of Amagasaki. Some sites near the cities of Osaka, Kishiwada, sand Sakai registered ng/kg levels of NPAHs, but individual NPAH concentrations were relatively lower than those in previous studies. The sources were estimated using principal component analysis, and NPAHs were derived from exhaust gases of automobiles and industries at some sites...
March 5, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28269008/selection-of-an-optimal-feature-set-to-predict-heart-transplantation-outcomes
#15
Dennis Medved, Pierre Nugues, Johan Nilsson
Heart transplantation (HT) is a life saving procedure, but a limited donor supply forces the surgeons to prioritize the recipients. The understanding of factors that predict mortality could help the doctors with this task. The objective of this study is to find locally optimal feature sets to predict survival of HT patients for different time periods. To this end, we applied logistic regression together with a greedy forward and backward search. As data source, we used the United Network for Organ Sharing (UNOS) registry, where we extracted adult patients (>17 years) from January 1997 to December 2008...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258069/marmoset-flavin-containing-monooxygenase-3-in-liver-is-a-major-benzydamine-and-sulindac-sulfide-oxygenase
#16
Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
Common marmosets (Callithrix jacchus) are potentially primate models for preclinical drug metabolism studies because the molecular characteristics of cytochrome P450 (P450) enzymes have similarities between this species and humans. However, characterization of non-P450 enzymes have not been clarified in marmosets. Here, we report characterization of flavin-containing monooxygenase (FMO) 1-5 identified in marmoset tissues. Marmoset FMO forms shared high amino acid sequence identities (93-95%) and phylogenetic closeness with human homologue FMO forms...
March 3, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28251702/kidney-allograft-surveillance-biopsy-practices-across-us-transplant-centers-a-unos-survey
#17
Rajil Mehta, Wida Cherikh, Puneet Sood, Sundaram Hariharan
BACKGROUND: The approach to the diagnosis and management of Sub-Clinical Rejection (SCR) in kidney transplant recipients remains controversial. METHODS: We conducted a survey through UNOS across US transplant centers regarding their approach to surveillance biopsies and reasons for the non-performance of surveillance biopsies. RESULTS: Responses were obtained from 106/238 centers (45%) and only 18 (17%) of the centers performed surveillance biopsies on all patients and 22 (21%) performed biopsy for select cases...
March 2, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28244795/dietas-bajas-en-hidratos-de-carbono-para-diab%C3%A3-ticos-de-tipo-2-revisi%C3%A3-n-sistem%C3%A3-tica
#18
Javier Valenzuela Mencía, Rafael Fernández Castillo, María Begoña Martos Cabrera, José Luis Gómez-Urquiza, Luis Albendín García, Guillermo Arturo Cañadas de la Fuente
Introducción: usualmente se ha recomendado a personas diabéticas seguir una dieta baja en grasas. Sin embargo, las dietas bajas en carbohidratos (DBCH) parecen ser, al menos, igual de efectivas que las bajas en grasas, incluso aportan mejores resultados en algunos casos en cuanto a control glicémico, disminución de peso corporal y mejora de marcadores de riesgo cardiovascular.Objetivos: analizar el efecto de las DBCH con respecto a dietas bajas en grasas (DBG) u otras, en cuanto a glucemia basal, hemoglobina glicosilada (HbA1c), peso corporal, colesterol total y triglicéridos...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28244780/evaluaci%C3%A3-n-y-comparaci%C3%A3-n-de-cinco-calibres-de-pliegues-cut%C3%A3-neos
#19
José Fernandes Filho, Alexis Caniuqueo Vargas, Cintia Campolina Duarte Rocha, Claudio Hernández Mosqueira, Paula Roquetti Fernandes, Sandro Fernandes da Silva, Rodrigo Ramirez-Campillo, Guissela Quiroz Sievers
Introducción: en el campo de la evaluación antropométrica, la validación y precisión de los calibres de pliegues cutáneos son fundamentales en el conocimiento efectivo de la composición corporal.Objetivo: el objetivo del estudio fue evaluar y comparar 5 modelos de calibre de pliegues cutáneos, uno de ellos digital -Prime Vision (PV), y los mecánicos Harpenden (HP), Sanny (SN), Cescorf (CE) y Lange (LA)-, a través de la densidad y grasa corporal.Material y métodos: formaron parte del estudio 35 hombres (21,5 ± 2,7 años; 72,22 ± 8,04 kg; 1,76 ± 0,06 m)...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28244778/las-medidas-antropom%C3%A3-tricas-como-indicadores-predictivos-de-riesgo-metab%C3%A3-lico-en-una-poblaci%C3%A3-n-mexicana
#20
Teresa Domínguez-Reyes, Irma Quiroz-Vargas, Aralia Berenice Salgado-Bernabé, Lorenzo Salgado-Goytia, José Francisco Muñoz-Valle, Isela Parra-Rojas
Introducción: actualmente se considera que la acumulación de grasa corporal a nivel central se asocia con la presencia de hipertrigliceridemia, hipertensión arterial y diabetes. El índice de masa corporal (IMC) se ha utilizado para identificar la obesidad en la población general, pero no permite determinar la distribución de la grasa corporal, por lo que se pueden utilizar otras medidas antropométricas para evaluar la adiposidad y determinar su relación con la presencia de alteraciones metabólicas que presentan las personas con exceso de peso...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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