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Rei Kaneko, Shojiro Sawada, Ai Tokita, Rieko Honkura, Noriko Tumura, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Kenji Uno, Junta Imai, Tetsuya Yamada, Yukiya Miyachi, Hideyuki Hasegawa, Hiroshi Kanai, Yasushi Ishgaki, Hideki Katagiri
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria...
February 14, 2018: Diabetes Research and Clinical Practice
L Sibulesky, C E Kling, C Blosser, C K Johnson, A P Limaye, R Bakthavatsalam, N Leca, J D Perkins
KDRI introduced in 2009 included Hepatitis C serologic but not viremic status of the donors. With NAT testing now being mandatory, further evaluation of these donors is possible. We conducted a retrospective matched case-control analysis of adult deceased donor kidney transplants performed between 12/5/2014 to 12/31/2016 with the KDRI score and HCV Ab and NAT testing status obtained from UNOS database. The 205 aviremic Hep C Ab+ NAT - kidney transplants were compared to KDRI matched control kidneys that were Hep C Ab-NAT-...
February 16, 2018: American Journal of Transplantation
Joshua Lee, In Gi Kim, Young Min Oh, Chan-Hee Park, Cheol Sang Kim
We have investigated the effect of flow rate on shear stress and in turn thrombus formation on a lab-on-a-chip with a microchannel that is suitable for cell culture and growth. Using a combination of Arduino UNO, Arduino Motor Shield, and a SERVO stepper motor, we created a pump system that closely mimics the in vivo conditions of the human body. With this system, we achieved continuous flow of blood and observed attached platelets at the bottom of the collagen coated microslide, confirming that with shear stress, thrombus formation increases...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Tomoki Kato, Masanao Sato, Hitoshi Shimamoto, Kiyu Uno, Kazutoshi Yokomachi, Yuko Konishi, Kazutaka Kamitani, Maiko Nishibori, Noboru Ohta, Ryohei Ishige, Kevin Lee White, Nobuyuki Otozawa, Tomoyasu Hirai, Atsushi Takahara
It is well-known that mixture of isotactic and syndiotactic PMMA forms a stereocomplex consisting of multi-helical structure in which an isotactic chain is surrounded by a syndiotactic chain. Here we report the basic structure of the stereocomplex formed when the syndiotactic PMMA chains are tethered to a silicon substrate and form a high-density polymer brush. The influence of geometric confinement was investigated by preparing the high-density polymer brushes on a flat and spherical substrate. In both cases, mixing the untethered isotactic PMMA with the grafted syndiotactic PMMA led to the formation of a stereocomplex with multi-helical structure...
February 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Mika Murata, Kosuke Kosai, Shunsuke Yamauchi, Daisuke Sasaki, Norihito Kaku, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
Lascufloxacin showed potent activity against Streptococcus pneumoniae with GyrA or ParC mutation (first-step mutants). The frequency of selecting resistant strains tended to be lower for lascufloxacin than levofloxacin and garenoxacin after drug exposure in first-step mutants, but was similar in the comparison between lascufloxacin and moxifloxacin. The increase in MIC was smaller for lascufloxacin than for levofloxacin, garenoxacin, and moxifloxacin when clinical strains with only ParC mutation were exposed to the corresponding drug...
February 12, 2018: Antimicrobial Agents and Chemotherapy
Maximilian Niyazi, Sebastian Adeberg, David Kaul, Anne-Laure Boulesteix, Nina Bougatf, Daniel F Fleischmann, Arne Grün, Anna Krämer, Claus Rödel, Franziska Eckert, Frank Paulsen, Kerstin A Kessel, Stephanie E Combs, Oliver Oehlke, Anca-Ligia Grosu, Annekatrin Seidlitz, Annika Lattermann, Mechthild Krause, Michael Baumann, Maja Guberina, Martin Stuschke, Volker Budach, Claus Belka, Jürgen Debus
BACKGROUND AND PURPOSE: Reirradiation (reRT) is a valid option with considerable efficacy in patients with recurrent high-grade glioma, but it is still not known which patients might be optimal candidates for a second course of irradiation. This study validated a newly developed prognostic score independently in an external patient cohort. MATERIAL AND METHODS: The reRT risk score (RRRS) is based on a linear combination of initial histology, clinical performance status, and age derived from a multivariable model of 353 patients...
February 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Yoshiharu Uno
No abstract text is available yet for this article.
February 12, 2018: Scandinavian Journal of Gastroenterology
George Cholankeril, Humberto C Gonzalez, Sanjaya Satapathy, Stevan A Gonzalez, Menghan Hu, Mohammad Ali Khan, Eric R Yoo, Andrew A Li, Donghee Kim, Satheesh Nair, Robert J Wong, Paul Y Kwo, Stephen A Harrison, Zobair M Younossi, Keith D Lindor, Aijaz Ahmed
BACKGROUND & AIMS: Data on the differences in ethnicity and race among patients with primary biliary cholangitis (PBC) awaiting liver transplantation (LT) are limited. We evaluated liver transplant waitlist trends and outcomes based on ethnicity and race in patients with PBC in the United States. METHODS: Using the United Network for Organ Sharing (UNOS) registry, we collected data on patients with PBC on the liver transplant waitlist, and performed analysis with a focus on ethnicity and race-based variations clinical manifestations, waitlist mortality and LT rates from 2000 to 2014...
February 7, 2018: Clinical Gastroenterology and Hepatology
Katsuhiro Uno, Kazutoshi Murotomi, Yasuhiro Kazuki, Mitsuo Oshimura, Yoshihiro Nakajima
We have developed a bioluminescence-based non-destructive cytotoxicity assay in which cell viability and membrane damage are simultaneously evaluated using Emerald luciferase (ELuc) and endoplasmic reticulum (ER)-targeted copepod luciferase (GLuc-KDEL), respectively, by using multi-integrase mouse artificial chromosome (MI-MAC) vector. We have demonstrated that the time-dependent concentration response curves of ELuc luminescence intensity and WST-1 assay, and GLuc-KDEL luminescence intensity and lactate dehydrogenase (LDH) activity in the culture medium accompanied by cytotoxicity show good agreement in toxicant-treated ELuc- and GLuc-KDEL-expressing HepG2 stable cell lines...
February 8, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
Akifumi Yamamura, Shun Watanabe, Mayumi Uno, Masato Mitani, Chikahiko Mitsui, Junto Tsurumi, Nobuaki Isahaya, Yusuke Kanaoka, Toshihiro Okamoto, Jun Takeya
Two-dimensional (2D) layered semiconductors are a novel class of functional materials that are an ideal platform for electronic applications, where the whole electronic states are directly modified by external stimuli adjacent to their electronic channels. Scale-up of the areal coverage while maintaining homogeneous single crystals has been the relevant challenge. We demonstrate that wafer-size single crystals composed of an organic semiconductor bimolecular layer with an excellent mobility of 10 cm2 V-1 s-1 can be successfully formed via a simple one-shot solution process...
February 2018: Science Advances
Martha Alicia Higareda-Almaraz, Paz Alejandra Gutiérrez-Monraz, Ruth Alejandrina Castillo-Sánchez, Juan Carlos Barrera-de León, Ana Bertha Zavalza-Gómez, Enrique Higareda-Almaraz
Objetivo: Identificar las complicaciones asociadas al catéter percutáneo en recién nacidos pretérmino y a término. Método: Estudio transversal comparativo. Se incluyeron recién nacidos que tenían insertado un catéter percutáneo, con resultados de cultivo de sangre y segmento distal del catéter. Se formaron dos grupos: pretérmino y a término. Se calcularon la razón de momios (RM) y el intervalo de confianza del 95% (IC 95%). Resultados: Se analizaron datos de 50 recién nacidos por grupo...
2018: Gaceta Médica de México
Leonel Fierro-Arias, Pilar Simón-Díaz, Rosa María Ponce-Olivera, Roberto Arenas-Guzmán
Objetivo: Conocer la felicidad y la satisfacción laboral de los dermatólogos en México. Método: Estudio descriptivo, mediante encuesta en línea dirigida a dermatólogos especialistas, graduados y con ejercicio en México. Se incluyeron elementos demográficos, el Índice de Felicidad de Pemberton (con validación local) y preguntas para evaluar la satisfacción personal. Se realizaron medidas de tendencia central y dispersión; para comparar las variables categóricas, se utilizaron tablas de contingencia para ji al cuadrado, y al comparar variables cuantitativas con distribución normal se utilizó la prueba t de Student...
2018: Gaceta Médica de México
Toru Oshio, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
1. The common marmoset (Callithrix jacchus) is a useful experimental animal to evaluate the pharmacokinetics of drug candidates. Cytochrome P450 (P450) 2B enzyme in marmoset livers has been identified; however, only limited information on the enzymatic properties and distribution has been available. 2. Marmoset P450 2B6 amino acids showed high sequence identities (>86%) with those of primates including humans and cynomolgus monkeys. Phylogenetic analysis using amino acid sequences indicated that marmoset P450 2B6 was closer to human and cynomolgus monkey P450 2B6 than to P450 2B orthologs of other species, including pigs, dogs, rabbits, and rodents...
February 8, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Prashant Rao, Richard Smith, Zain Khalpey
No abstract text is available yet for this article.
February 1, 2018: Seminars in Thoracic and Cardiovascular Surgery
Jun Tanaka, Fumihiro Hirayama, Sayuri Yanase, Shusei Uno, Takashi Nakae, Akihito Kamizono, Hideaki Hanaki
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infects healthy individuals, although the precise cause remains unclear. CA-MRSA produces Panton-Valentine leukocidin (PVL), which often causes severe invasive infection; however, antitoxin drugs against PVL are limited. Intravenous immunoglobulin (IVIg) possesses antitoxin activity, but unfortunately, the optimal dose is unknown. Here, we measured the PVL neutralizing antibody titer in the plasma of Japanese individuals and sera of American donors...
February 3, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Mohammed Saqr, Uno Fors, Matti Tedre
BACKGROUND: Collaborative learning facilitates reflection, diversifies understanding and stimulates skills of critical and higher-order thinking. Although the benefits of collaborative learning have long been recognized, it is still rarely studied by social network analysis (SNA) in medical education, and the relationship of parameters that can be obtained via SNA with students' performance remains largely unknown. The aim of this work was to assess the potential of SNA for studying online collaborative clinical case discussions in a medical course and to find out which activities correlate with better performance and help predict final grade or explain variance in performance...
February 6, 2018: BMC Medical Education
Shuhei Sumino, Misae Uno, Hsin-Ju Huang, Yen-Ku Wu, Ilhyong Ryu
Alkenylation and allylation of alkyl iodides with alkenyl and allyl sulfones, respectively, took place under Pd/photoirradiation system. The initial alkyl radical, derived from a single electron transfer between Pd(0) and RI, underwent the title transformations. Pd(0) was regenerated through a reductive elimination of PhSO2PdI, which is formed by the combination of the sulfonyl radical and the palladium radical. The addition of water was effective, presumably by pushing the equilibrium through hydrolysis of PhSO2I...
February 6, 2018: Organic Letters
Ami Sambai, Max Coltheart, Akira Uno
In English, the size of the regularity effect on word reading-aloud latency decreases across position of irregularity. This has been explained by a sublexical serially operating reading mechanism. It is unclear whether sublexical serial processing occurs in reading two-character kanji words aloud. To investigate this issue, we studied how the position of atypical character-to-sound correspondences influenced reading performance. When participants read inconsistent-atypical words aloud mixed randomly with nonwords, reading latencies of words with an inconsistent-atypical correspondence in the initial position were significantly longer than words with an inconsistent-atypical correspondence in the second position...
February 5, 2018: Psychonomic Bulletin & Review
T Kodaira, Y Kagami, T Shibata, N Shikama, Y Nishimura, S Ishikura, K Nakamura, Y Saito, Y Matsumoto, T Teshima, Y Ito, T Akimoto, K Nakata, T Toshiyasu, K Nakagawa, Y Nagata, T Nishimura, T Uno, M Kataoka, A Yorozu, M Hiraoka
Background: We assessed the non-inferiority of accelerated fractionation (AF) (2.4 Gy/fraction) compared with standard fractionation (SF) (2 Gy/fraction) regarding progression-free survival (PFS) in patients with T1-2N0M0 glottic cancer (GC). Patients and Methods: In this multi-institutional, randomized, phase 3 trial, patients were enrolled from 32 Japanese institutions. Key inclusion criteria were GC T1 - 2N0M0, age 20 - 80, Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1, and adequate organ function...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Erin L Albers, Miranda C Bradford, Joshua M Friedland-Little, Borah J Hong, Mariska S Kemna, Jonathan M Chen, Yuk M Law
PH is a risk factor for GL after HTx. However, traditional parameters are not reliable predictors of risk in children. We hypothesized that DPI (dPAP and DPG) are predictive of GL in pediatric HTx recipients. The UNOS/SRTR database was reviewed to identify pediatric HTx recipients (age <18 years) between 1994 and 2013. Recipients with pretransplant hemodynamic data were grouped by diagnosis (CMP or CHD), and the groups were analyzed separately. Bivariate Cox regression analysis examined the association between hemodynamic variables and GL...
February 3, 2018: Pediatric Transplantation
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