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https://www.readbyqxmd.com/read/28729052/tedizolid-inhibits-muc5ac-production-induced-by-methicillin-resistant-staphylococcus-aureus-in-human-airway-epithelial-cells
#1
Kazuaki Takeda, Norihito Kaku, Yoshitomo Morinaga, Kosuke Kosai, Naoki Uno, Yoshifumi Imamura, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
The innate immune system plays an important role in early immunity against respiratory tract infection. Although airway epithelial cells produce mucus to eliminate pathogens and irritants, hypersecretion of mucus is harmful for the host as it may cause airway obstruction and inhibit influx of antimicrobial agents. It has been reported that several antimicrobial agents have an immunomodulatory effect in vitro and in vivo, but little is known about whether tedizolid, a novel oxazolidinone, can modulate immune responses...
July 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28726802/strain-induced-skeletal-rearrangement-of-a-polycyclic-aromatic-hydrocarbon-on-a-copper-surface
#2
Akitoshi Shiotari, Takahiro Nakae, Kota Iwata, Shigeki Mori, Tetsuo Okujima, Hidemitsu Uno, Hiroshi Sakaguchi, Yoshiaki Sugimoto
Controlling the structural deformation of organic molecules can drive unique reactions that cannot be induced only by thermal, optical or electrochemical procedures. However, in conventional organic synthesis, including mechanochemical procedures, it is difficult to control skeletal rearrangement in polycyclic aromatic hydrocarbons (PAHs). Here, we demonstrate a reaction scheme for the skeletal rearrangement of PAHs on a metal surface using high-resolution noncontact atomic force microscopy. By a combination of organic synthesis and on-surface cyclodehydrogenation, we produce a well-designed PAH-diazuleno[1,2,3-cd:1',2',3'-fg]pyrene-adsorbed flatly onto Cu(001), in which two azuleno moieties are highly strained by their mutual proximity...
July 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28725168/comprehensive-registry-of-esophageal-cancer-in-japan-2010
#3
Yuji Tachimori, Soji Ozawa, Hodaka Numasaki, Ryu Ishihara, Hisahiro Matsubara, Kei Muro, Tsuneo Oyama, Yasushi Toh, Harushi Udagawa, Takashi Uno
No abstract text is available yet for this article.
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28725068/response-to-uno
#4
Ching Lam, Gemma Chaddock, Luca Marciani Laurea, Carolyn Costigan, Eleanor Cox, Caroline Hoad, Susan Pritchard, Penny Gowland, Robin Spiller
No abstract text is available yet for this article.
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28725060/enigma-of-intestinal-gas-in-irritable-bowel-syndrome
#5
Yoshiharu Uno
No abstract text is available yet for this article.
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28720743/-usefulness-of-edoxaban-for-deep-cerebral-venous-sinus-thrombosis-with-hemorrhagic-infarction-a-case-report
#6
Takeo Amemiya, Toshio Uesaka, Katsuharu Kameda, Junji Uno, Shintaro Nagaoka, Yoshiaki Ikai, Hidefuku Gi
We describe a case of deep cerebral venous sinus thrombosis(DCVST)that was successfully treated by oral administration of the Xa inhibitor edoxaban. A 53-year-old man was admitted to our hospital because of a headache and undifferentiated dizziness. Computed tomography(CT)demonstrated a low-density area in the bilateral thalamus and high-density lesions in the internal cerebral veins(ICVs)and vein of Galen. Magnetic resonance imaging with diffusion-weighted images detected areas of hyperintensity in the bilateral thalamus...
July 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28715474/prognostic-role-of-neutrophil-lymphocyte-ratio-in-nasopharyngeal-carcinoma-a-meta-analysis
#7
Yukinori Takenaka, Takahiro Kitamura, Ryohei Oya, Naoki Ashida, Kotaro Shimizu, Kazuya Takemura, Yoshifumi Yamamoto, Atsuhiko Uno
BACKGROUND: Inflammatory markers are used to predict prognosis of nasopharyngeal carcinoma (NPC). Previous reports of neutrophil-to-lymphocyte ratio (NLR) and NPC mortality are inconsistent. This study aimed to quantify the prognostic impact of NLR on NPC. METHODS: The primary outcome was overall survival (OS), and the secondary outcomes were disease-specific survival (DSS), progression-free survival (PFS) and distant metastasis-free survival (DMFS). We systematically searched electronic databases, identified articles reporting an association between NLR and NPC prognosis...
2017: PloS One
https://www.readbyqxmd.com/read/28712677/extracorporeal-membrane-oxygenation-following-lung-transplantation-indications-and-survival
#8
Michael S Mulvihill, Babatunde A Yerokun, Robert Patrick Davis, David N Ranney, Mani A Daneshmand, Matthew G Hartwig
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is employed to rescue patients with early graft dysfunction after lung transplantation (LTx). Rates of post-LTx ECMO and subsequent outcomes have been limited to single-center reports. METHODS: UNOS registry was queried for LTx recipients from March 2015 to March 2016; 2,001 recipients were identified and stratified by need for post-LTx ECMO. Logistic regression was used to determine variables associated with post-LTx ECMO...
July 1, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28710943/survival-after-recurrence-of-stage-i-iii-breast-colorectal-or-lung-cancer
#9
Michael J Hassett, Hajime Uno, Angel M Cronin, Nikki M Carroll, Mark C Hornbrook, Paul Fishman, Debra P Ritzwoller
BACKGROUND: The experiences of patients with recurrent cancer are assumed to reflect those of patients with de novo stage IV disease; yet, little is truly known because most registries lack recurrence status. Using two databases with excellent recurrence and death information, we examined determinants of survival duration after recurrence of breast (BC), colorectal (CRC), and lung cancers (LC). METHODS: Recurrence status was abstracted from the medical records of patients who participated in the Cancer Care Outcomes Research and Surveillance study and who received care at two Cancer Research Network sites-the Colorado and Northwest regions of Kaiser Permanente...
July 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28708886/kir3dl01-upregulation-on-gut-natural-killer-cells-in-response-to-siv-infection-of-kir-and-mhc-class-i-defined-rhesus-macaques
#10
Moritz Ries, Matthew R Reynolds, Ksenia Bashkueva, Kristin Crosno, Saverio Capuano, Trent M Prall, Roger Wiseman, David H O'Connor, Eva G Rakasz, Hajime Uno, Jeffrey D Lifson, David T Evans
Natural killer cells provide an important early defense against viral pathogens and are regulated in part by interactions between highly polymorphic killer-cell immunoglobulin-like receptors (KIRs) on NK cells and their MHC class I ligands on target cells. We previously identified MHC class I ligands for two rhesus macaque KIRs: KIR3DL01 recognizes Mamu-Bw4 molecules and KIR3DL05 recognizes Mamu-A1*002. To determine how these interactions influence NK cell responses, we infected KIR3DL01+ and KIR3DL05+ macaques with and without defined ligands for these receptors with SIVmac239, and monitored NK cell responses in peripheral blood and lymphoid tissues...
July 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28707374/localization-and-functional-analysis-of-the-insect-specific-rabx4-in-the-brain-of-bombyx-mori
#11
Tomohide Uno, Masayuki Furutani, Katsuhiko Sakamoto, Yuichi Uno, Kengo Kanamaru, Akira Mizoguchi, Susumu Hiragaki, Makio Takeda
Rab proteins are small monomeric GTPases/GTP-binding proteins, which form the largest branch of the Ras superfamily. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane trafficking. RabX4 is an insect-specific Rab protein that has no close homolog in vertebrates. There is little information about insect-specific Rab proteins. RabX4 was expressed in Escherichia coli and subsequently purified. Antibodies against Bombyx mori RabX4 were produced in rabbits for western immunoblotting and immunohistochemistry...
July 14, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28705019/a-rare-case-of-pediatric-primary-cardiac-tumor-in-a-patient-with-down-syndrome
#12
Kimiaki Okada, Ayumu Masuoka, Kentaro Hotoda, Yoshimasa Uno, Takaaki Suzuki
Although hematological malignancies are a known complication of Down syndrome, few reports have described cases involving solid tumors. We describe the case of a 3-year-old Down syndrome girl with a primary solid cardiac tumor. Outpatient echocardiography after intracardiac repair of a ventricular septal defect at 6 months of age revealed a highly mobile pedunculated mass (8 × 9 mm) on the free wall of the right atrium. Due to potential incarceration of the mass in the tricuspid orifice, it was excised under extracorporeal circulation and cardiac arrest...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28692074/-prima-guerra-mondiale-e-salute-mentale-uno-studio-retrospettivo-su-veterani-ricoverati-in-un-ospedale-psichiatrico-tra-il-1915-e-il-1918
#13
Paolo Lagonia, Matteo Aloi, Fabio Magliocco, Gregorio Cerminara, Cristina Segura-Garcia, Valeria Del Vecchio, Mario Luciano, Andrea Fiorillo, Pasquale De Fazio
RIASSUNTO. Scopo. L'associazione tra malattia mentale e guerra è stata più volte indagata. Nei reduci sono stati riscontrati alti livelli di sintomi depressivi e un aumento del rischio di suicidio. In questo studio abbiamo indagato le condizioni di salute mentale dei soldati italiani che hanno partecipato alla "Grande Guerra" che sono stati ricoverati in un Ospedale Psichiatrico in Italia. Metodi. Il campione è composto da 498 soldati ospedalizzati durante la prima guerra mondiale tra il 1915 e il 1918, e 498 pazienti civili ricoverati in due diversi periodi (1898-1914, 1919-1932)...
May 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28692072/-psicoterapia-e-tempo-psicologico-uno-studio-di-caso
#14
Álvaro Quiñones, Francisco Ceric, Carla Ugarte, Adele De Pascale
RIASSUNTO. Scopo. Il presente lavoro è uno studio di caso comparativo, parte di una ricerca sul processo psicoterapeutico. La ricerca descrive la percezione del tempo soggettivo in due processi psicoterapeutici, uno con esito positivo e l'altro no. Metodi. Abbiamo studiato, con un orientamento cognitivista, due processi psicoterapeutici, videoregistrati e trascritti integralmente seduta per seduta. Inizialmente è stata condotta un'analisi qualitativa (con approccio top-down) per codificare la qualità, e realizzata per identificare categorie dei diversi tipi di tempo soggettivo, che dipendono dai differenti stati di benessere psicologico...
May 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28689465/design-synthesis-and-taste-evaluation-of-a-high-intensity-umami-imparting-oxazole-based-compound
#15
Yusuke Amino, Yu-Ki Tahara, Kei Yamada, Masakazu Nakazawa, Uno Tagami, Takaho Tajima, Motonaka Kuroda
Umami taste is imparted predominantly by monosodium glutamate (MSG) and 5'-ribonucleotides. Recently, several different classes of hydrophobic umami-imparting compounds, the structures of which are quite different from MSG, have been reported. To obtain a novel umami-imparting compound, N-cinnamoyl phenethylamine was chosen as the lead compound, and a rational structure-optimization study was conducted on the basis of the pharmacophore model of previously reported compounds. The extremely potent umami-imparting compound 2-[[[2-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-oxazolyle]methoxy]methyl]pyridine, which exhibits 27,000 times the umami taste of MSG, was found...
July 10, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28689458/marmoset-pulmonary-cytochrome-p450-2f1-oxidizes-biphenyl-and-7-ethoxycoumarin-and-hepatic-human-p450-substrates
#16
Shotaro Uehara, Yasuhiro Uno, Toru Oshio, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
1. A potentially useful animal model for preclinical studies is the common marmoset (Callithrix jacchus). In this study, using reverse-transcription polymerase chain reaction from marmoset livers, we identified a novel cytochrome P450 (P450) 2F1 cDNA with an open reading frame of 1473 bp. 2. High sequence identities of 92-94% with primate P450 2F amino acid sequences were indicated by deduced amino acid sequences of P450 2F1 cDNA. Phylogenetic analysis indicates that marmoset P450 2F1 is more congruent with primate P450 2F forms than those of other species such as rodents...
July 8, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28686070/effects-of-aging-and-rifampicin-pretreatment-on-the-pharmacokinetics-of-human-cytochrome-p450-probes-caffeine-warfarin-omeprazole-metoprolol-and-midazolam-in-common-marmosets-genotyped-for-cytochrome-p450-2c19
#17
Akiko Toda, Shotaro Uehara, Takashi Inoue, Masahiro Utoh, Takashi Kusama, Makiko Shimizu, Yasuhiro Uno, Masayuki Mogi, Erika Sasaki, Hiroshi Yamazaki
1. The pharmacokinetics were investigated for human cytochrome P450 probes after single intravenous and oral administrations of 0.20 and 1.0 mg/kg, respectively, of caffeine, warfarin, omeprazole, metoprolol, and midazolam to aged (10-14 years old, n = 4) or rifampicin-treated/young (3 years old, n = 3) male common marmosets all genotyped as heterozygous for a cytochrome P450 2C19 variant. 2. Slopes of the plasma concentration-time curves after intravenous administration of warfarin and midazolam were slightly, but significantly (two-way analysis of variance), decreased in aged marmosets compared with young marmosets...
July 7, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28680624/giant-cell-arteritis-with-polymyalgia-rheumatica-on-fdg-pet-ct
#18
Akira Baba, Kimiichi Uno, Yumi Okuyama, Yohei Munetomo, Shintaro Nakajima, Kennosuke Mizushina, Hideto Kameda
If there is no pain in the temporal artery, the diagnosis of giant cell arteritis (GCA) may be delayed and blindness may occur. Therefore, FDG-PET/CT is important as a modality for diagnosis of GCA. When GCA is suspected and F-18 FDG-PET/CT is performed, it is worthwhile to pay attention to shoulder and hip joints as polymyalgia rheumatica commonly presents with GCA.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28675357/the-european-policy-for-liver-allocation-in-patients-affected-by-hepatocellular-carcinoma
#19
Stefano Di Sandro, Fabio Ferla, Andrea Lauterio, Iacopo Mangoni, Riccardo De Carlis, Vincenzo Buscemi, Luciano De Carlis
The main goal of allocation system is to guarantee an equal access to the limited resource of liver grafts for every class of patients on the waiting list, balancing between the ethical principles of equity, utility, benefit, need, and fairness. The aim of this review was to analyze liver allocation policies among these organizations, focusing on HCC. The European area considered for this analysis included 6 macro-areas or countries, which are congregated from the same policy of liver sharing and allocation...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28674353/acute-acalculous-cholecystitis-caused-by-giardia-lamblia
#20
Hiromichi Araki, Shuya Shimizu, Katsumi Hayashi, Tomonori Yamada, Atsunori Kusakabe, Hiroshi Kanie, Yusuke Mizuno, Issei Kojima, Akitoshi Saitou, Kazuhiro Nagao, Yuka Suzuki, Tadashi Toyohara, Takanori Suzuki, Erika Uchida, Konomu Uno, Takahiro Nakazawa
We report a case of a 70-year-old man with acute acalculous cholecystitis caused by Giardia lamblia. Contrast-enhanced computed tomography (CT) showed distention of the gallbladder due to a pericholecystic abscess without gallstones. Magnetic resonance cholangiopancreatography and drip infusion cholecystocholangiography-CT demonstrated a stricture of the hilar bile duct and cystic duct obstruction. We conducted transpapillary bile duct brush cytology and a biopsy of the hilar bile duct stricture; numerous active trophozoites of Giardia lamblia were observed without malignant findings...
2017: Internal Medicine
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