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https://www.readbyqxmd.com/read/29676191/treatment-according-to-guidelines-may-bridge-the-gender-gap-in-outcome-for-patients-with-stage-t1-urinary-bladder-cancer
#1
Carin Sjöström, Andreas Thorstenson, Viveka Ströck, Abolfazl Hosseini-Aliabad, Firas Aljabery, Fredrik Liedberg, Amir Sherif, Per-Uno Malmström, Johan Rosell, Truls Gårdmark, Staffan Jahnson
OBJECTIVE: The aim of this investigation was to study differences between male and female patients with stage T1 urinary bladder cancer (UBC) regarding intravesical instillation therapy, second resection and survival. MATERIALS AND METHODS: This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, excluding those treated with primary cystectomy. Differences between groups were evaluated using chi-squared tests and logistic regression, and survival was investigated using Kaplan-Meier and log-rank tests and Cox proportional hazards analysis...
April 20, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29675209/calcium-ii-catalyzed-enantioselective-conjugate-additions-of-amines
#2
Brice E Uno, Rachel D Dicken, Louis R Redfern, Charlotte M Stern, Greg G Krzywicki, Karl A Scheidt
The direct enantioselective chiral calcium(ii)·phosphate complex (Ca[CPA]2 )-catalyzed conjugate addition of unprotected alkyl amines to maleimides was developed. This mild catalytic system represents a significant advance towards the general convergent asymmetric amination of α,β-unsaturated electrophiles, providing medicinally relevant chiral aminosuccinimide products in high yields and enantioselectivities. Furthermore, the catalyst can be reused directly from a previously chromatographed reaction and still maintain both high yield and selectivity...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674778/-un-processo-che-pu%C3%A3-gettare-luce-sulla-cosiddetta-paura-di-s%C3%A3-nel-disturbo-ossessivo-compulsivo-l-identificazione-retrospettiva-delle-motivazioni-e-delle-inclinazioni
#3
Gherardo Mannino, Rossella Guerini
RIASSUNTO. Al fine di comprendere meglio la psicopatologia del disturbo ossessivo-compulsivo (DOC), in anni recenti è stata prestata una crescente attenzione alla cosiddetta "paura di sé" (fear of self), vale a dire la paura che le persone con DOC nutrono di ospitare dentro di sé aspetti inaccettabili. Tuttavia, l'esatta dinamica di questo fenomeno ancora non è chiara: di conseguenza, allo scopo di delucidarla meglio, sarà qui descritto uno specifico processo psicologico denominato Identificazione Retrospettiva delle Motivazioni e delle Inclinazioni (IRMI)...
March 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29674762/current-multidisciplinary-approach-to-fertility-preservation-for-breast-cancer-patients
#4
Yuko Takahashi, Tadahiko Shien, Ai Sakamoto, Yuko Tsuyumu, Ryo Yoshioka, Maya Uno, Minami Hatono, Mariko Kochi, Kengo Kawada, Takahiro Tsukioki, Takayuki Iwamoto, Hirokuni Ikeda, Naruto Taira, Junji Matsuoka, Mikiya Nakatsuka, Hiroyoshi Doihara
Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29672442/more-than-just-wait-time-regional-differences-in-liver-transplant-outcomes-for-hepatocellular-carcinoma
#5
Rachel Hogen, Mary Lo, Joseph DiNorcia, Lingyun Ji, Yuri Genyk, Linda Sher, Kiran Dhanireddy
BACKGROUND: Regional allocation of deceased donor livers has led to variable wait times for HCC patients on the liver transplant list. The purpose of our study was to evaluate how regional differences in wait time affect outcomes for HCC patients. METHODS: A retrospective, observational study was performed using the OPTN database from 2/27/2002 to 9/25/2015. The cumulative incidences of transplant and waitlist death as well as intention-to-treat and posttransplant survival were evaluated for patients ≥ 18 years of age listed for DDLT with stage II HCC exception points in each UNOS region...
April 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29670388/colonic-transit-time-and-pressure-based-on-bernoulli-s-principle
#6
Yoshiharu Uno
Purpose: Variations in the caliber of human large intestinal tract causes changes in pressure and the velocity of its contents, depending on flow volume, gravity, and density, which are all variables of Bernoulli's principle. Therefore, it was hypothesized that constipation and diarrhea can occur due to changes in the colonic transit time (CTT), according to Bernoulli's principle. In addition, it was hypothesized that high amplitude peristaltic contractions (HAPC), which are considered to be involved in defecation in healthy subjects, occur because of cecum pressure based on Bernoulli's principle...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29664403/socioeconomic-disparities-in-adherence-and-outcomes-after-heart-transplant-a-unos-united-network-for-organ-sharing-registry-analysis
#7
Brian Wayda, Autumn Clemons, Raymond C Givens, Koji Takeda, Hiroo Takayama, Farhana Latif, Susan Restaino, Yoshifumi Naka, Maryjane A Farr, Paolo C Colombo, Veli K Topkara
BACKGROUND: There is mixed evidence of racial and socioeconomic disparities in heart transplant outcomes. Their underlying cause-and whether individual- or community-level traits are most influential-remains unclear. The current study aimed to characterize socioeconomic disparities in outcomes and identify time trends and mediators of these disparities. METHODS AND RESULTS: We used United Network for Organ Sharing registry data and included 33 893 adult heart transplant recipients between 1994 and 2014...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29660764/prognostic-utility-of-meld-xi-in-adult-congenital-heart-disease-patients-undergoing-cardiac-transplantation
#8
Evan D Adams, Nicholas J Jackson, Tim Young, Eugene C DePasquale, Leigh C Reardon
BACKGROUND: MELD-XI (Model for End-Stage Liver Disease eXcluding INR) at cardiac transplant has demonstrated prognostic survival utility, but has not been specifically validated in adult congenital heart disease (ACHD) in a registry study. METHODS: Adults undergoing first time orthotopic heart transplant from 2005-2015 in the UNOS (United Network for Organ Sharing) registry were examined in parallel: ACHD (n=543), ischemic dilated cardiomyopathy (IDCM, n=6,954) and valvular heart disease (VHD, n=355)...
April 16, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29659047/the-changing-face-of-adult-posttransplant-lymphoproliferative-disorder-changes-in-histology-between-1999-2013
#9
Donald E Tsai, Stephen Bagley, Ran Reshef, Abraham Shaked, Roy D Bloom, Vivek Ahya, Lee Goldberg, Albert Chung, Fotini Debonera, Stephen J Schuster, Scott F Huntington
Posttransplant lymphoproliferative disorder (PTLD) typically presents with either polymorphic or monomorphic histology. While both are the end result of immunosuppressive therapies, their origins are felt to be different with different prognoses and responsiveness to therapy, resulting in two different malignancies. We attempted to confirm reports suggesting that the relative frequency of these two histologies is shifting over time. We analyzed 3040 adult PTLD cases in the UNOS OPTN database from 1999 to 2013...
April 16, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29655914/importance-of-cynomolgus-monkeys-in-development-of-monoclonal-antibody-drugs
#10
REVIEW
Kazuhide Iwasaki, Yasuhiro Uno, Masahiro Uto, Hiroshi Yamazaki
Animal species used in the preclinical studies for development of monoclonal antibody (mAb) drugs are surveyed in this review. Relevant animal species for preclinical studies of mAb candidates are those express desired epitope of mAb candidates. Cynomolgus monkeys cross-react with mAb drugs much higher than other animal species commonly used in preclinical studies such as absorption, distribution, metabolism and excretion (ADME), efficacy, and toxicity studies, for development of new drugs. Moreover, plasma exposure of the mAb drugs in humans is predicted well from the exposure in the monkeys, and the placental transfer of immunoglobulin G (IgG, all the mAb drugs contain IgG) from mother to fetus is similar between humans and the monkeys from a viewpoint of time course and plasma level of IgG transferred...
March 20, 2018: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29650917/-a-case-of-primary-spinddle-cell-carcinoma-of-the-breast
#11
Hiroshi Kawai, Chihiro Yoshikawa, Kento Kawasaki, Norichika Iga, Ryosuke Yoshida, Naohisa Waki, Futoshi Uno, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita, Shinichiro Miyoshi
A 76-year-old female underwent breast-conserving surgery of the right breast and sentinel lymph node biopsy for primary breast cancer. Three years later, mammography and ultrasonography showed a small nodule in the right breast. There was nothing abnormal in the left breast. Three months later, she complained of a huge and rapid growing mass in the left breast. Malignant cells were obtained on fine needle aspiration biopsy in the right breast tumor. But it was not possible to diagnose whether the left breast tumor was benign or malignant on fine needle aspiration biopsy and needle biopsy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643297/investigation-of-pharmacological-responses-to-anti-diabetic-drugs-in-female-spontaneously-diabetic-torii-sdt-fatty-rats-a-new-nonalcoholic-steatohepatitis-nash-model
#12
Yasufumi Toriniwa, Tomoyuki Saito, Katsuhiro Miyajima, Yukihito Ishii, Kinuko Uno, Tatsuya Maekawa, Tohru Matsui, Shinichi Kume, Takahisa Yamada, Takeshi Ohta
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease, and some patients develop hepatic cirrhosis/carcinoma. Animal models play key roles in the development of new therapies for NASH. In this study, the pharmacological effects of metformin and pioglitazone were investigated in female Spontaneously Diabetic Torii (SDT) fatty rats to verify the utility of this model. The anti-diabetic drugs were administered to SDT fatty rats fed a cholesterol-enriched diet from 4 to 25 weeks, and changes in food intake, body weight, and blood chemistry parameters were evaluated every 4 weeks...
April 10, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29627772/altered-cerebral-blood-flow-in-the-anterior-cingulate-cortex-is-associated-with-neuropathic-pain
#13
Keisuke Watanabe, Shigeki Hirano, Kazuho Kojima, Kengo Nagashima, Hiroki Mukai, Takatoshi Sato, Minoru Takemoto, Koji Matsumoto, Takashi Iimori, Sagiri Isose, Shigeki Omori, Kazumoto Shibuya, Yukari Sekiguchi, Minako Beppu, Hiroshi Amino, Tomoki Suichi, Koutaro Yokote, Takashi Uno, Satoshi Kuwabara, Sonoko Misawa
OBJECTIVE: To assess the cerebral blood flow (CBF) in patients with diabetic neuropathic pain, and its changes after duloxetine therapy. METHODS: Using iodine-123-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (IMP-SPECT), we performed a cross-sectional study of 44 patients with diabetes, and compared CBF in those with (n = 24) and without neuropathic pain (n = 20). In patients with neuropathic pain, we also longitudinally assessed changes in CBF 3 months after treatment with duloxetine...
April 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29626440/in-vivo-and-in-vitro-diclofenac-5-hydroxylation-mediated-primarily-by-cytochrome-p450-3a-enzymes-in-common-marmoset-livers-genotyped-for-p450-2c19-variants
#14
Kazuyuki Nakanishi, Shotaro Uehara, Takashi Kusama, Takashi Inoue, Kanami Shimura, Yusuke Kamiya, Norie Murayama, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki, Hiroshi Yamazaki
Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. An anti-inflammatory drug, diclofenac is reportedly metabolized mainly by human cytochrome P450 (P450) 2C9 to 4'-hydroxydiclofenac and minorly by P450 3A4 to 5-hydroxydiclofenac that leads to reactive intermediates. In this study, in vivo pharmacokinetics in six marmosets and in vitro metabolism in nine marmoset liver microsomes were analyzed using diclofenac to evaluate marmosets as preclinical drug metabolism models...
April 4, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29624574/need-for-speed-an-optimized-gridding-approach-for-spatially-explicit-disease-simulations
#15
Stefan Sellman, Kimberly Tsao, Michael J Tildesley, Peter Brommesson, Colleen T Webb, Uno Wennergren, Matt J Keeling, Tom Lindström
Numerical models for simulating outbreaks of infectious diseases are powerful tools for informing surveillance and control strategy decisions. However, large-scale spatially explicit models can be limited by the amount of computational resources they require, which poses a problem when multiple scenarios need to be explored to provide policy recommendations. We introduce an easily implemented method that can reduce computation time in a standard Susceptible-Exposed-Infectious-Removed (SEIR) model without introducing any further approximations or truncations...
April 6, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29624047/parallel-proteomic-workflow-for-mass-spectrometric-analysis-of-tissue-samples-preserved-by-different-methods
#16
Aleš Holfeld, Alberto Valdés, Per-Uno Malmström, Ulrika Segersten, Sara Bergström Lind
Formalin-fixed and paraffin-embedded (FFPE) and optimal cutting temperature (OCT)-embedded and frozen tissue specimens in biobanks are highly valuable in clinical studies but proteomic and post-translational modification (PTM) studies using mass spectrometry (MS) have been limited due to structural arrangement of proteins and contaminations from embedding material. This study aims to develop a parallel proteomic workflow for FFPE and OCT/frozen samples that allows for large-scale, quick, reproducible, qualitative, and quantitative high-resolution MS analysis...
April 13, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29621562/development-and-validation-of-a-scoring-system-for-prediction-of-insulin-requirement-for-optimal-control-of-blood-glucose-during-glucocorticoid-treatments
#17
Mikako Kawashima, Koichiro Taguchi, Yoshihiko Kitada, Masahiro Yamauchi, Takahide Ikeda, Kazuo Kajita, Daisuke Murakami, Hideyuki Okada, Yoshihiro Uno, Ichiro Mori, Tatsuo Ishizuka, Hiroyuki Morita
AIMS: We have developed and validated a novel scoring system to predict insulin requirement for optimal control of blood glucose during glucocorticoid (GC) treatments, by retrospective analyses of clinical parameters before GC treatment. METHODS: Three hundred-three adults (the Developing set) undergoing their first treatment of prednisolone (PSL) were divided into two groups, depending on treatment with or without insulin. Independent risk factors for insulin requirement were identified by a stepwise logistic regression analysis after univariate analyses between the two groups...
April 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29617912/impact-of-antiretroviral-regimens-on-csf-viral-escape-in-a-prospective-multicohort-study-of-art-experienced-hiv-1-infected-adults-in-the-united-states
#18
Shibani S Mukerji, Vikas Misra, David R Lorenz, Hajime Uno, Susan Morgello, Donald Franklin, Ronald J Ellis, Scott Letendre, Dana Gabuzda
Background: Cerebrospinal fluid (CSF) viral escape occurs in 4-20% of HIV-infected adults, yet the impact of antiretroviral therapy (ART) on CSF escape is unclear. Methods: Prospective study of 1063 participants with baseline plasma viral load (VL) ≤400 copies/ml between 2005-2016. Odds ratio for ART regimens (PI with nucleoside reverse transcriptase inhibitor [PI+NRTI] versus other ART) and CSF escape was estimated using mixed-effects models. Drug resistance mutation frequencies were calculated...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29617717/adding-a-new-analytical-procedure-with-clinical-interpretation-in-the-tool-box-of-survival-analysis
#19
H Uno, B Claggett, L Tian, H Fu, B Huang, D H Kim, L J Wei
No abstract text is available yet for this article.
April 3, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29616318/re-transplantation-for-hepatic-artery-thrombosis-a-national-perspective
#20
Shu Kwun Lui, Catherine R Garcia, Xiaonan Mei, Roberto Gedaly
BACKGROUND: Hepatic artery thrombosis (HAT) is a major complication after liver transplantation that commonly requires re-transplantation. METHODS: We queried the UNOS dataset for all patients transplanted between 1995 and 2015 for HAT. RESULTS: We identified 623 patients who underwent re-transplantation for HAT with a mean age of 51.25 + 10.4 years. The mean BMI was 26.72 kg/m2 , and mean MELD score was 19.62 + 9.09. There was a higher proportion of male patients, with higher prevalence of pre-transplant portal vein thrombosis (7...
April 3, 2018: World Journal of Surgery
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