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Sumeyye Samur, Brian Kues, Turgay Ayer, Mark S Roberts, Fasiha Kanwal, Chin Hur, Drew Michael S Donnell, Raymond T Chung, Jagpreet Chhatwal
BACKGROUND & AIMS: Oral direct-acting antivirals (DAAs) for hepatitis C virus (HCV) treatment offer new hope to both pre- and post-liver transplant (LT) patients. However, whether to treat HCV patients pre- versus post-LT is not clear, as treatment can improve liver function but could reduce the chance of receiving a LT while on the waiting list. Our objective was to evaluate the cost-effectiveness of pre-LT versus post-LT HCV treatment with oral DAAs in decompensated cirrhotic patients on the LT waiting list...
June 17, 2017: Clinical Gastroenterology and Hepatology
#2
Gina Lladó, Rocío González-Soltero, María José Blanco Fernández de Valderrama
Introducción: la adolescencia es un periodo vulnerable para padecer trastornos de la conducta alimentaria (TCA) como la anorexia y la bulimia nerviosas. La insatisfacción corporal, uno de los factores precipitantes de los TCA, conduce a las adolescentes a la búsqueda de información sobre dietas en internet. En este contexto, las páginas pro-Ana (proanorexia) y pro-Mía (probulimia) difunden contenidos altamente perjudiciales para la salud relacionados con la pérdida de peso y los TCA.Objetivos: en el presente trabajo se analizan la cantidad, el posicionamiento, la calidad y la difusión de las páginas pro-Ana y pro-Mía...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#3
José Ramón Alvero Cruz, Mauro Ronconi, Jerónimo Carmelo García Romero, Margarita Carrillo de Albornoz Gil, Manuel Jíménez López, Lorena Correas Gómez, Elvis Álvarez Carnero
Introduction: The infl uence of exercise in trained subjects has beneficial effects in the physical fi tness and body composition; however, detraining has an unfavorable effect in all of them. Objective: The current study was designed to ascertain the infl uence of a six week-detraining period on body composition in both well-trained young soccer players (GE, n = 43) and sedentary male adolescents (GC, n = 10). Methods: Forty-three well-trained soccer players and ten sedentary adolescents accepted to participate in the study...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#4
Sanjaya K Satapathy, Yu Jiang, James D Eason, Satish K Kedia, Emily Wong, Ashwani K Singal, Elizabeth A Tolley, Donna Hathaway, Satheesh Nair, Jason M Vanatta
Nonalcoholic Steatohepatitis (NASH) has become an increasingly important indication for liver transplantation (LT), and there has been a particular concern of excessive cardiovascular-related mortality in this group METHODS: Using the United Network for Organ Sharing-Standard Transplant Analysis and Research (UNOS-STAR) dataset, we reviewed data on 56,995 adult transplants (January 2002 through June 2013). 3,170 NASH liver-only recipients were identified and were matched with 3,012 non-NASH HCV+ and 3,159 non-NASH HCV- controls [matched 1:1 based on gender, age at LT (±3 years), and MELD score (±3)] RESULTS: Cox regression analysis revealed significantly lower hazard of all-cause (HR 0...
June 16, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
#5
Eileen M Hsich, Eugene H Blackstone, Lucy Thuita, Dennis M McNamara, Joseph G Rogers, Hemant Ishwaran, Jesse D Schold
BACKGROUND: There are sex differences in mortality while awaiting heart transplantation, and the reason remains unclear. METHODS AND RESULTS: We included all adults in the Scientific Registry of Transplant Recipients placed on the heart transplant active waitlist from 2004 to 2015. The primary end point was all-cause mortality. Multivariable Cox proportional hazards models were performed to evaluate survival by United Network for Organ Sharing (UNOS) status at the time of listing...
June 2017: Circulation. Heart Failure
#6
Masahiro Utoh, Tomonori Miura, Takashi Kusama, Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno, Hiroshi Yamazaki
Cynomolgus monkey cytochrome P450 2C9 (formerly known as P450 2C43) variation was reportedly associated with metabolic clearance of the antiretroviral drug efavirenz in vivo (of three wild-type, one heterozygote, and two homozygote animals), being unlikely in the case of human P450 2B6-dependent efavirenz clearance. In this study, the liver microsomal elimination rates of efavirenz for the same individual animals previously treated with intravenous/oral administrations of efavirenz showed significant reductions associated with the P450 2C9 p...
June 13, 2017: Biopharmaceutics & Drug Disposition
#7
Jonathan G Stine, Patrick G Northup, George J Stukenborg, Scott L Cornella, Daniel G Maluf, Shawn J Pelletier, Curtis K Argo
AIM: Geographic disparities persist in the U.S. despite locoregional organ sharing policies. The impact of national organ sharing policies on waiting-list mortality on a regional basis remains unknown. METHODS: Data on all adult liver transplants between February 1, 2002 and March 31, 2015 were obtained from UNOS/OPTN. Multivariable Cox proportional hazards models were constructed in a time-to-event analysis to estimate waiting-list mortality for the pre- and post-Share35 eras...
June 11, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#8
Katsuharu Kameda, Junji Uno, Ryosuke Otsuji, Nice Ren, Shintaro Nagaoka, Kazushi Maeda, Yoshiaki Ikai, Hidefuku Gi
BACKGROUND AND PURPOSE: Optimal thresholds for ischemic penumbra detected by CT perfusion (CTP) in patients with acute ischemic stroke (AIS) have not been elucidated. In this study we investigated optimal thresholds for salvageable ischemic penumbra and the risk of hemorrhagic transformation (HT). METHODS: A total of 156 consecutive patients with AIS treated with mechanical thrombectomy (MT) at our hospital were enrolled. Absolute (a) and relative (r) CTP parameters including cerebral blood flow (aCBF and rCBF), cerebral blood volume (aCBV and rCBV), and mean transit time (aMTT and rMTT) were evaluated for their value in detecting ischemic penumbra in each of seven arbitrary regions of interest defined by the major supplying blood vessel...
June 9, 2017: Journal of Neurointerventional Surgery
#9
S Hirose, T Iijima, I Adachi, K Adamczyk, H Aihara, S Al Said, D M Asner, H Atmacan, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, E Barberio, P Behera, M Berger, B Bhuyan, J Biswal, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, M Danilov, N Dash, S Di Carlo, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, P Goldenzweig, B Golob, D Greenwald, J Grygier, J Haba, K Hara, J Hasenbusch, K Hayasaka, H Hayashii, T Higuchi, W-S Hou, C-L Hsu, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, Y Jin, D Joffe, K K Joo, T Julius, Y Kato, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, R Kumar, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, J MacNaughton, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyake, H Miyata, R Mizuk, G B Mohanty, H K Moon, T Mori, R Mussa, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, M Niiyama, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, Y Onuki, W Ostrowicz, P Pakhlov, G Pakhlova, B Pal, C W Park, H Park, S Paul, L Pesántez, R Pestotnik, L E Piilonen, K Prasanth, M Ritter, A Rostomyan, M Rozanska, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, C Van Hulse, G Varner, K E Varvell, A Vossen, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, E Won, Y Yamashita, H Ye, J Yelton, C Z Yuan, Z P Zhang, V Zhilich, V Zhulanov, A Zupanc
We report the first measurement of the τ lepton polarization P_{τ}(D^{*}) in the decay B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ} as well as a new measurement of the ratio of the branching fractions R(D^{*})=B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}ℓ^{-}ν[over ¯]_{ℓ}), where ℓ^{-} denotes an electron or a muon, and the τ is reconstructed in the modes τ^{-}→π^{-}ν_{τ} and τ^{-}→ρ^{-}ν_{τ}. We use the full data sample of 772×10^{6} BB[over ¯] pairs recorded with the Belle detector at the KEKB electron-positron collider...
May 26, 2017: Physical Review Letters
#10
Anat R Tambur, Benoit Audry, Corinne Antoine, Caroline Suberbielle, Denis Glotz, Christian Jacquelinet
We reported that current assignment of HLA-DQ is a barrier to organ allocation. Here we simulated the impact of incorporating HLA-DQ antigens and antibodies as A/B and αβ allelic variants, respectively, on calculated PRA and probability of finding potential compatible donors (PCD). A cohort of 1224 donors and 2075 sensitized candidates was analyzed using HLA-DQαβ allelic (study) versus serologic (current practice) nomenclature. A significant (p<10(-4) ) decrease in cPRA was observed with higher impact for male versus female, and first transplant versus retransplant (p<10(-4) ), affecting mostly patients with moderate cPRA (30-80%)...
June 8, 2017: American Journal of Transplantation
#11
Jan Grünewald, Yunho Jin, Julie Vance, Jessica Read, Xing Wang, Yongqin Wan, Huanfang Zhou, Weijia Ou, Heath E Klock, Eric C Peters, Tetsuo Uno, Ansgar Brock, Bernhard H Geierstanger
Phosphopantetheine transferases (PPTases) can be used to efficiently prepare site-specific antibody-drug conjugates (ADCs) by enzymatically coupling coenzyme A (CoA)-linker payloads to 11-12 amino acid peptide substrates inserted into antibodies. Here, a two-step strategy is established wherein in a first step, CoA analogs with various bioorthogonal reactivities are enzymatically installed on the antibody for chemical conjugation with a cytotoxic payload in a second step. Because of the high structural similarity of these CoA analogs to the natural PPTase substrate CoA-SH, the first step proceeds very efficiently and enables the use of peptide tags as short as 6 amino acids compared to the 11-12 amino acids required for efficient one-step coupling of the payload molecule...
June 14, 2017: Bioconjugate Chemistry
#12
Allison J Kwong, Aparna Goel, Ajitha Mannalithara, W Ray Kim
BACKGROUND AND AIMS: The Share 35 policy was implemented in June 2013 to improve equity in access to liver transplantation (LT) between patients with fulminant liver failure and those with cirrhosis and severe hepatic decompensation. The aim of this study was to assess post-LT outcomes after Share 35. METHODS: Relevant donor, procurement, and recipient data were extracted from the OPTN/UNOS database. All adult deceased donor LT from January 1, 2010 to March 31, 2016 were included in the analysis...
June 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#13
Julia Álvarez Hernández
Este año hemos elegido como tema central del curso el "Abordaje nutricional del paciente crónico complejo", por entender que se trata de uno de los retos más importantes que tenemos los profesionales sanitarios que formamos parte de un sistema sanitario que tiene amenazada su sostenibilidad.El envejecimiento de la población es una realidad de cifras abrumadoras. Como lo es también el aumento de prevalencia de pacientes crónicos. En 2016, el 19,9% de la población española tenía 65 años o más y en 2050 se estima que un 30%-35% será mayor de 65 años y habrá algo más de 4 millones de octogenarios...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#14
Fred O Ugwumba, Agharighom D Okoh, Kevin N Echetabu, Emeka I Udeh, Ikenna I Nnabugwu
CONTEXT: Prostate cancer (PCa) is frequently diagnosed at advanced stages in Nigeria. AIMS: To determine the screen detected PCa prevalence in a suburban community and explore any relationships between prostate-specific antigen (PSA) and anthropometric measurements. SETTINGS AND DESIGN: Nsukka is a town and local government area (LGA) in Southeast Nigeria in Enugu State. Towns that share a common border with Nsukka are Edem Ani, Alor-uno, Opi, Orba, and Ede-Oballa...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
#15
Lars Dyrskjøt, Thomas Reinert, Ferran Algaba, Emil Christensen, Daan Nieboer, Gregers G Hermann, Karin Mogensen, Willemien Beukers, Mirari Marquez, Ulrika Segersten, Søren Høyer, Benedicte P Ulhøi, Arndt Hartmann, Robert Stöhr, Sven Wach, Roman Nawroth, Kristina Schwamborn, Cane Tulic, Tatjana Simic, Kerstin Junker, Niels Harving, Astrid C Petersen, Jørgen B Jensen, Bastian Keck, Marc-Oliver Grimm, Marcus Horstmann, Tobias Maurer, Ewout W Steyerberg, Ellen C Zwarthoff, Francisco X Real, Núria Malats, Per-Uno Malmström, Torben F Ørntoft
BACKGROUND: Progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) is life-threatening and cannot be accurately predicted using clinical and pathological risk factors. Biomarkers for stratifying patients to treatment and surveillance are greatly needed. OBJECTIVE: To validate a previously developed 12-gene progression score to predict progression to MIBC in a large, multicentre, prospective study. DESIGN, SETTING, AND PARTICIPANTS: We enrolled 1224 patients in ten European centres between 2008 and 2012...
June 2, 2017: European Urology
#16
Misaki Ishibashi, Hiroki Yoshikawa, Yuichi Uno
Strawberry fruit contain the allergenic Fra a proteins, members of the pathogenesis-related 10 protein family that causes oral allergic syndrome symptoms. Fra a proteins are involved in the flavonoid biosynthesis pathway, which might be important for color development in fruits. Auxin is an important plant hormone in strawberry fruit that controls fruit fleshiness and ripening. In this study, we treated strawberry fruits with exogenous auxin or auxin inhibitors at pre- and post-harvest stages, and analyzed Fra a transcriptional and translational expression levels during fruit development by real-time PCR and immunoblotting...
June 2, 2017: International Journal of Molecular Sciences
#17
Antonio Simone Laganà, Salvatore Giovanni Vitale, Francesca Maria Salmeri, Onofrio Triolo, Helena Ban Frangež, Eda Vrtačnik-Bokal, Lily Stojanovska, Vasso Apostolopoulos, Roberta Granese, Vincenza Sofo
The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a physiological process that affects 90% of women, while endometriosis occurs in only 10% of cases; it also does not explain the endometriotic foci distant from the pelvis, nor explains the cases of endometriosis in male patients. The immunological alterations of the peritoneal fluid explains the effects of disease, such as the inhibition of the physiological processes of cytolysis, but does not explain the cause...
June 2017: Medical Hypotheses
#18
Yoshiro Tanaka, Tomohisa Nagoshi, Makoto Kawai, Goki Uno, Satoshi Ito, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D Tanaka, Kosuke Minai, Takayuki Ogawa, Michihiro Yoshimura
High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise relationship by proposing structural equation models. The study population consisted of 1432 cases with ischemic heart disease who underwent cardiac catheterization. Multiple regression analyses and covariance structure analyses were performed to elucidate the cause-and-effect relationship between UA level and LV ejection fraction (LVEF)...
May 30, 2017: Scientific Reports
#19
Masako Ohara, Takashi Okada, Chika Kubota, Yukako Nakamura, Tomoko Shiino, Branko Aleksic, Mako Morikawa, Aya Yamauchi, Yota Uno, Satomi Murase, Setsuko Goto, Atsuko Kanai, Tomoko Masuda, Masahiko Ando, Norio Ozaki
AIM: Although the association between maternal depression and bonding failure during pregnancy and after delivery has been investigated, the causal relationships remain unclear. METHODS: A total of 751 women (mean [SD] age 32.1 [4.4] years) completed the Mother-Infant Bonding Questionnaire and the Edinburgh Postnatal Depression Scale in early pregnancy before week 25 (T1), in late pregnancy around week 36 (T2), and 5 days after delivery (T3). We created a structural regression model to clarify the relationships between depressive mood and bonding failure during pregnancy and 5 days after delivery...
May 29, 2017: Psychiatry and Clinical Neurosciences
#20
Esther Asensio, Marcos López-Hoyos, Íñigo Romón, Jesús Ontañón, David San Segundo
BACKGROUND AND OBJECTIVES: The calculated panel reactive of antibodies (cPRAs) necessary for kidney donor-pair exchange and highly sensitized programs are estimated using different panel reactive antibody (PRA) calculators based on big enough samples in Eurotransplant (EUTR), United Network for Organ Sharing (UNOS), and Canadian Transplant Registry (CTR) websites. However, those calculators can vary depending on the ethnic they are applied. Here, we develop a PRA calculator used in the Spanish Program of Transplant Access for Highly Sensitized patients (PATHI) and validate it with EUTR, UNOS, and CTR calculators...
2017: Frontiers in Immunology
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