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Jihong Liu Clarke, Lisa Paruch, Mihaela-Olivia Dobrica, Iuliana Caras, Catalin Tucureanu, Adrian Onu, Sonya Ciulean, Crina Stavaru, Andre Eerde, Yanliang Wang, Hege Steen, Sissel Haugslien, Catalina Petrareanu, Catalin Lazar, Ioan Popescu, Ralph Bock, Jean Dubuisson, Norica Branza-Nichita
The hepatitis C virus (HCV) is a major etiologic agent for severe liver diseases (e.g., cirrhosis, fibrosis and hepatocellular carcinoma). Approximately 140 million people have chronic HCV infections and about 500,000 die yearly from HCV-related liver pathologies. To date, there is no licenced vaccine available to prevent HCV infection and production of an HCV vaccine remains a major challenge. Here we report the successful production of the HCV E1E2 heterodimer, an important vaccine candidate, in an edible crop (lettuce, Lactuca sativa) using Agrobacterium-mediated transient expression technology...
April 17, 2017: Plant Biotechnology Journal
Hsing-Yu Chen, Chia-Chien Wei, Che-Yu Lin, Li-Wei Chen, I-Cheng Lu, Jyehong Chen
This study compared two nonlinear distortion compensation techniques, SSII cancellation (in the frequency domain) and Volterra filtering (in the time domain), in a >50-Gbps/λ OFDM-IMDD LR-PON. Experiment results for SNR, BER, and data rate (based on a bit-loading algorithm) revealed that the performance of frequency-domain SSII cancellation is unaffected by power fading; however, it depends heavily on the precision of the mathematical model. Conversely, although time-domain Volterra filtering is affected by the faded waveform, adaptive-weighting provides flexibility in dealing with mixed nonlinear distortion, particularly that associated with the interplay between fiber dispersion and fiber nonlinearity...
March 6, 2017: Optics Express
Charalampos Fragkoulis, Athanasios Pappas, Georgios I Papadopoulos, Georgios Stathouros, Aristodimos Fragkoulis, Konstantinos Ntoumas
OBJECTIVES: To evaluate the impact of distal ureter management on oncological results after open nephroureterectomy (ONU) comparing transurethral resection of the intramural ureter to conventional open excision, as controversy still exists about the method of choice for managing the distal ureter and bladder cuff during ONU. PATIENTS AND METHODS: We retrospectively collected data from 378 patients who underwent ONU for upper urinary tract transitional cell carcinoma (UUT-TCC) from 1988 to 2009...
March 2017: Arab Journal of Urology
J Zurita, D W Denning, A Paz-Y-Miño, M B Solís, L M Arias
There is a dearth of data from Ecuador on the burden of life-threatening fungal disease entities; therefore, we estimated the burden of serious fungal infections in Ecuador based on the populations at risk and available epidemiological databases and publications. A full literature search was done to identify all epidemiology papers reporting fungal infection rates. WHO, ONU-AIDS, Index Mundi, Global Asthma Report, Globocan, and national data [Instituto Nacional de Estadística y Censos (INEC), Ministerio de Salud Pública (MSP), Sociedad de Lucha Contra el Cáncer (SOLCA), Instituto Nacional de Donación y Trasplante de Órganos, Tejidos y Células (INDOT)] were reviewed...
February 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
Jian-Ye Liu, Ying-Bo Dai, Fang-Jian Zhou, Zhi Long, Yong-Hong Li, Dan Xie, Bin Liu, Jin Tang, Jing Tan, Kun Yao, Le-Ye He
BACKGROUND: Many studies have reported the oncological outcomes between open radical nephroureterectomy (ONU) and laparoscopic radical nephroureterectomy (LNU) of upper tract urothelial carcinoma (UTUC). However, few data have focused on the oncological outcomes of LNU in the subgroup of localized and/or locally advanced UTUC (T1-4/N0-X). The purpose of this study was to compare the oncological outcomes of LNU vs. ONU for the treatment in patients with T1-4/N0-X UTUC. METHODS: We collected and analyzed the data and clinical outcomes retrospectively for 265 patients who underwent radical nephroureterectomy for T1-4/N0-X UTUC between April 2000 and April 2013 at two Chinese tertiary hospitals...
January 17, 2017: BMC Surgery
Marco Costa, Leonardo Bonetti, Manuela Bellelli, Claudio Lantieri, Valeria Vignali, Andrea Simone
OBJECTIVE: Four studies were conducted to assess bicyclist conspicuity enhancement at night by the application of reflective tape (ECE/ONU 104) to the bicycle rear frame and to pedal cranks. BACKGROUND: Previous studies have tested the benefits of reflective markings applied to bicyclist clothing. Reflective jackets however need to be available and worn while reflective markings enhance conspicuity without any active behavior by the bicyclist. METHOD: In the first study, reflective tape was applied to the rear frame...
May 2017: Human Factors
Chinwe C Onu, Shari L Dworkin, Linnet G Ongeri, Patrick Oyaro, Thomas C Neylan, Craig R Cohen, Elizabeth A Bukusi, Grace Rota, Susan M Meffert
For people living with HIV, exposure to sexual violence (SV) is associated with decreased adherence to antiretroviral medication, a primary predictor of their survival. Identification of risk factors for SV is a pressing issue in sub-Saharan Africa, where the global majority of HIV-positive women live and the prevalence of SV against women is high. We used qualitative data to examine SV against HIV-positive women enrolled in HIV care in Kenya. Respondents identified husbands as perpetrators of SV in the context of women's efforts to use condoms as directed by HIV care providers...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ming Luo, Rong Hu, Wei Li, Qi Yang, Shaohua Yu
A cost-effective structure is proposed for the optical network unit (ONU) transceivers in coherent ultra-dense wavelength division multiplexing passive optical network (UDWDM-PON), which is based on a single directly modulated laser (DML). This is the first time that a DML is used as both optical transmitter in upstream and local oscillator (LO) for coherent detection in downstream. The impact of extinction ratio (ER) of signal from DML is investigated and optimized by adapting the driving amplitude and bias of DML...
June 13, 2016: Optics Express
Chien-Hung Yeh, Chi-Wai Chow
In this investigation, we demonstrate a new colorless orthogonal-frequency-division-multiplexing (OFDM) wavelength-division-multiplexing passive optical network (WDM-PON) system with Rayleigh backscattering (RB) noise mitigation. Here, only a single laser source at the central office (CO) is needed to produce the downstream signal and distributed continuous-wave (CW) carrier, which will then be modulated at the optical networking unit (ONU) to produce the upstream signal. Single side-band (SSB) modulation is used to wavelength-shift the distributed CW carrier, which will be launched into a reflective semiconductor optical amplifier (RSOA) based ONU for directly modulation of 5...
May 16, 2016: Optics Express
Geunyong Kim, Hark Yoo, Dongsoo Lee, Youngsun Kim, Hyuk Lim
We present a congestion estimation technique (CET) to estimate the optical network unit (ONU) registration success ratio for the ONU registration process in passive optical networks. An optical line terminal (OLT) estimates the number of collided ONUs via the proposed scheme during the serial number state. The OLT can obtain congestion level among ONUs to be registered such that this information may be exploited to change the size of a quiet window to decrease the collision probability. We verified the efficiency of the proposed method through simulation and experimental results...
July 1, 2016: Optics Letters
Su Zhang, You Luo, Cheng Wang, Sheng-Jun Fu, Li Yang
Background. Several factors have been validated as predictors of disease recurrence in upper tract urothelial carcinoma. However, the oncological outcomes between different surgical approaches (open nephroureterectomy versus laparoscopic nephroureterectomy, ONU vs LNU) remain controversial. Therefore, we performed a meta-analysis to evaluate the oncological outcomes associated with different surgical approaches. Methods. We conducted an electronic search of the PubMed, Embase, ISI Web of Knowledge and Cochrane Library electronic databases through November 2015, screened the retrieved references, collected and evaluated the relevant information...
2016: PeerJ
Leonard Ogbonna Ajah, Perpetus Chudi Ibekwe, Fidelis Agwu Onu, Ogah Emeka Onwe, Thecla Chinonyelum Ezeonu, Innocent Omeje
INTRODUCTION: Fetal distress has been shown to contribute to the increasing caesarean section rate. There has been controversy on the usefulness of clinical diagnosis of fetal distress using only the intermittent counting of the fetal heart rate and/or passage of meconium-stained liquor. AIM: To evaluate the clinical diagnosis of fetal distress and the perinatal outcome. MATERIALS AND METHODS: This was a retrospective study in which the case records of the patients, who were diagnosed of fetal distress at Federal Teaching Hospital, Abakaliki, Nigeria, from January 1, 2008 to December 31, 2014, were collated...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Chinwe Onu, Linnet Ongeri, Elizabeth Bukusi, Craig R Cohen, Thomas C Neylan, Patrick Oyaro, Grace Rota, Faith Otewa, Kevin L Delucchi, Susan M Meffert
No abstract text is available yet for this article.
2016: Trials
E Kainne Dokubo, Bethrand Odume, Virginia Lipke, Custodio Muianga, Eugene Onu, Ayodotun Olutola, Lucy Ukachukwu, Patricia Igweike, Nneka Chukwura, Emperor Ubochioma, Everistus Aniaku, Chinyere Ezeudu, Joseph Agboeze, Gabriel Iroh, Elvina Orji, Okezue Godwin, Hasiya Bello Raji, S A Aboje, Chijioke Osakwe, Henry Debem, Mustapha Bello, Dennis Onotu, Susan Maloney
Tuberculosis (TB) is the leading cause of infectious disease mortality worldwide, accounting for more than 1.5 million deaths in 2014, and is the leading cause of death among persons living with human immunodeficiency virus (HIV) infection (1). Nigeria has the fourth highest annual number of TB cases among countries, with an estimated incidence of 322 per 100,000 population (1), and the second highest prevalence of HIV infection, with 3.4 million infected persons (2). In 2014, 100,000 incident TB cases and 78,000 TB deaths occurred among persons living with HIV infection in Nigeria (1)...
March 18, 2016: MMWR. Morbidity and Mortality Weekly Report
Theone C Kon, Adrian Onu, Laurentiu Berbecila, Emilia Lupulescu, Alina Ghiorgisor, Gideon F Kersten, Yi-Qing Cui, Jean-Pierre Amorij, Leo Van der Pol
The aim of this study was to evaluate the impact of different inactivation and splitting procedures on influenza vaccine product composition, stability and recovery to support transfer of process technology. Four split and two whole inactivated virus (WIV) influenza vaccine bulks were produced and compared with respect to release criteria, stability of the bulk and haemagglutinin recovery. One clarified harvest of influenza H3N2 A/Uruguay virus prepared on 25.000 fertilized eggs was divided equally over six downstream processes...
2016: PloS One
Chinwe Onu, Linnet Ongeri, Elizabeth Bukusi, Craig R Cohen, Thomas C Neylan, Patrick Oyaro, Grace Rota, Faith Otewa, Kevin L Delucchi, Susan M Meffert
BACKGROUND: Mental disorders are the leading global cause of years lived with disability; the majority of this burden exists in low and middle income countries (LMICs). Over half of mental illness is attributable to depression and anxiety disorders, both of which have known treatments. While the scarcity of mental health care providers is recognized as a major contributor to the magnitude of untreated disorders in LMICs, studies in LMICs find that evidence-based treatments for depression and anxiety disorders, such as brief, structured psychotherapies, are feasible, acceptable and have strong efficacy when delivered by local non-specialist personnel...
February 3, 2016: Trials
Jose A Altabas, David Izquierdo, Jose A Lazaro, Adolfo Lerin, Felix Sotelo, Ignacio Garces
1 Gbps full-duplex optical links for 6.25 GHz ultra dense WDM frequency slots are demonstrated and optimized for cost-effective metro-access networks. The OLT-ONU downlinks are based on 1 Gbps Nyquist-DPSK using MZM and single-detector heterodyne reception obtaining a sensitivity of -52 dBm. The ONU-OLT uplinks are based on 1 Gbps NRZ-DPSK by directly phase modulated DFB and also single-detector heterodyne reception obtaining same sensitivity of -52 dBm. The power budget of full-duplex link is 43 dB. These proposed links can provide service to 16 (32) users at each 100 (200) GHz WDM channel...
January 11, 2016: Optics Express
Jie Hyun Lee, Heuk Park, Sae-Kyoung Kang, Joon Ki Lee, Hwan Seok Chung
In this study, we propose and experimentally demonstrate a wavelength domain rogue-free ONU based on wavelength-pairing of downstream and upstream signals for time/wavelength division-multiplexed optical access networks. The wavelength-pairing tunable filter is aligned to the upstream wavelength channel by aligning it to one of the downstream wavelength channels. Wavelength-pairing is implemented with a compact and cyclic Si-AWG integrated with a Ge-PD. The pairing filter covered four 100 GHz-spaced wavelength channels...
November 30, 2015: Optics Express
U I Nwadike, K K Agwu, C U Eze, O C Okpala, A O Onu
Objective: The objective of this study was to develop a sonographic technique for the measurement of fetal interorbital distance (IOD) for gestational age (GA) determination and to establish a normogram of IOD for the local population. Methods: The fronto-transverse sonographic technique was established as a feasible and reproducible technique for IOD measurement. Two independent and experienced sonographers tested the technique and had a coefficient of variation of 17...
May 13, 2015: West Indian Medical Journal
Crina Stavaru, Adrian Onu, Emilia Lupulescu, Catalin Tucureanu, Orhan Rasid, Ene Vlase, Cristin Coman, Iuliana Caras, Alina Ghiorghisor, Laurentiu Berbecila, Vlad Tofan, Richard A Bowen, Nicole Marlenee, Airn Hartwig, Helle Bielefeldt-Ohmann, Susan L Baldwin, Neal Van Hoeven, Thomas S Vedvick, Chuong Huynh, Michael K O'Hara, Diana L Noah, Christopher B Fox
Millions of seasonal and pandemic influenza vaccine doses containing oil-in-water emulsion adjuvant have been administered in order to enhance and broaden immune responses and to facilitate antigen sparing. Despite the enactment of a Global Action Plan for Influenza Vaccines and a multi-fold increase in production capabilities over the past 10 years, worldwide capacity for pandemic influenza vaccine production is still limited. In developing countries, where routine influenza vaccination is not fully established, additional measures are needed to ensure adequate supply of pandemic influenza vaccines without dependence on the shipment of aid from other, potentially impacted first-world countries...
April 2, 2016: Human Vaccines & Immunotherapeutics
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