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https://www.readbyqxmd.com/read/27927678/first-line-intra-arterial-versus-intravenous-chemotherapy-in-unilateral-sporadic-group-d-retinoblastoma-evidence-of-better-visual-outcomes-ocular-survival-and-shorter-time-to-success-with-intra-arterial-delivery-from-retrospective-review-of-20%C3%A2-years-of-treatment
#1
Francis L Munier, Pascal Mosimann, Francesco Puccinelli, Marie-Claire Gaillard, Christina Stathopoulos, Susan Houghton, Ciara Bergin, Maja Beck-Popovic
PURPOSE: The introduction of intra-arterial chemotherapy (IAC) as salvage treatment has improved the prognosis for eye conservation in group D retinoblastoma. The aim of this study was to compare the outcomes of consecutive patients with advanced unilateral disease treated with either first-line intravenous chemotherapy (IVC) or first-line IAC. DESIGN: This is a retrospective mono-centric comparative review of consecutive patients. PATIENTS: Sporadic unilateral retinoblastoma group D cases treated conservatively at Jules-Gonin Eye Hospital and CHUV between 1997 and 2014...
December 7, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27913093/genome-of-the-carbapenemase-producing-clinical-isolate-elizabethkingia-miricola-em_chuv-and-comparative-genomics-with-elizabethkingia-meningoseptica-and-elizabethkingia-anophelis-evidence-for-intrinsic-multidrug-resistance-trait-of-emerging-pathogens
#2
Onya Opota, Seydina M Diene, Claire Bertelli, Guy Prod'hom, Philippe Eckert, Gilbert Greub
Elizabethkingia miricola is a Gram-negative non-fermenting rod emerging as a life-threatening human pathogen. The multidrug-resistant (MDR) carbapenemase-producing clinical isolate E. miricola EM_CHUV was recovered in the setting of severe nosocomial pneumonia. In this study, the genome of E. miricola EM_CHUV was sequenced and a functional analysis was performed, including a comparative genomic study with Elizabethkingia meningoseptica and Elizabethkingia anophelis. The resistome of EM_CHUV revealed the presence of a high number of resistance genes, including the presence of the blaGOB-13 and blaB-9 carbapenemase-encoding genes...
November 15, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27664985/therapeutic-coma-for-status-epilepticus-differing-practices-in-a-prospective-multicenter-study
#3
Vincent Alvarez, Jong Woo Lee, M Brandon Westover, Frank W Drislane, Jan Novy, Mohamed Faouzi, Nicola A Marchi, Barbara A Dworetzky, Andrea O Rossetti
OBJECTIVE: Our aim was to analyze and compare the use of therapeutic coma (TC) for refractory status epilepticus (SE) across different centers and its effect on outcome. METHODS: Clinical data for all consecutive adults (>16 years) with SE of all etiologies (except postanoxic) admitted to 4 tertiary care centers belonging to Harvard Affiliated Hospitals (HAH) and the Centre Hospitalier Universitaire Vaudois (CHUV) were prospectively collected and analyzed for TC details, mortality, and duration of hospitalization...
October 18, 2016: Neurology
https://www.readbyqxmd.com/read/27281944/-acute-neurorehabilitation-in-neurooncology-swiss-pilot-project-and-review-of-the-litterature
#4
REVIEW
Karin Diserens, Jean-Paul Robert, Cristina Pellet, Loric Berney, Marc Levivier, Andreas F Hottinger
New treatment modalities in oncology, radiation oncology and surgery have led to a significant improvement in life expectancy for cancer patients. Some will however develop severe neurologic deficits that will impact their quality of life. To limit this impact, it is essential to offer optimal neurorehabilitation. In this context, a pilot project of early and intensive neurorehabilitation for brain tumor patients has been set up. A collaboration between the teams of neurooncology, acute neurorehabilitation and neurosurgery from the CHUV and the Clinique La Lignière allows an intensive and direct neurorehabilitation following neurosurgery...
April 27, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27249322/new-ilae-versus-previous-clinical-status-epilepticus-semiologic-classification-analysis-of-a-hospital-based-cohort
#5
Andrea O Rossetti, Eugen Trinka, Christine Stähli, Jan Novy
OBJECTIVES: In 2015, the International League Against Epilepsy (ILAE) issued a new status epilepticus (SE) classification, including a detailed semiologic axis. This study assesses frequencies of SE forms in a cohort of adult patients, and explores differences and practical implications as compared to a seizure-type-bound classification. METHODS: The prospective adult SE registry of the Lausanne University Hospital (CHUV) was considered over 5 years (2011-2015); each SE episode was retrospectively reclassified for its semiology according to the new ILAE scheme...
July 2016: Epilepsia
https://www.readbyqxmd.com/read/26822138/isolation-complete-genome-sequencing-and-phylogenetic-analysis-of-the-first-chuzan-virus-in-china
#6
Fang Wang, Jun Lin, Jitao Chang, Yingying Cao, Shaomin Qin, Jianmin Wu, Li Yu
A Chuzan virus (CHUV), defined as GX871 here, was isolated from blood from a sentinel cattle firstly in China, and its full-length genome was sequenced in this study. The GX871 genome included 10 segments and 18914 bp, one base fewer than the CHUV prototype strain K-47 due to a one-base deletion in the 5' non-coding region of segment 8. A frameshift mutation was detected in a short coding region (1010-1026 nt) corresponding to the VP1 protein; this frameshift resulted in a five-amino acid mutation from 336CVLSY340 to 336YGAKL340...
February 2016: Virus Genes
https://www.readbyqxmd.com/read/26733292/complete-genome-sequence-of-a-chuzan-virus-strain-isolated-for-the-first-time-in-mainland-china
#7
Heng Yang, Lei Xiao, Jinxing Meng, Heli Xiong, Lin Gao, Defang Liao, Huachun Li
Chuzan virus (CHUV) belongs to the Palyam serogroup, causes bovine congenital disease, and is prevalent in Asia. To date, only one full Palyam virus (PALV) genome sequence, that of Japanese CHUV strain K47, has been reported. Sequence analysis indicates that PALV strains isolated from different geographical regions show significant diversity, which is mainly shaped by geographically independent evolution and genetic reassortment. Our understanding of the genetic characteristics of PALV is hampered by a very limited genomic sequence database...
April 2016: Archives of Virology
https://www.readbyqxmd.com/read/26685652/-incident-reporting-electronic-based-system-in-internal-medicine
#8
J Servet, P-A Bart, J-B Wasserfallen, J Castioni
How to recognize, announce and analyze incidents in internal medicine units is a daily challenge that is taught to all hospital staff. It allows suggesting useful improvements for patients, as well as for the medical department and the institution. Here is presented the assessment made in the CHUV internal medicine department one year after the beginning of the institutional procedure which promotes an open process regarding communication and risk management. The department of internal medicine underlines the importance of feedback to the reporters, ensures the staff of regular follow-up concerning the measures being taken and offers to external reporters such as general practioners the possibility of using this reporting system too...
November 4, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26598141/safety-of-human-immunisation-with-a-live-attenuated-mycobacterium-tuberculosis-vaccine-a-randomised-double-blind-controlled-phase-i-trial
#9
RANDOMIZED CONTROLLED TRIAL
François Spertini, Régine Audran, Reza Chakour, Olfa Karoui, Viviane Steiner-Monard, Anne-Christine Thierry, Carole E Mayor, Nils Rettby, Katia Jaton, Laure Vallotton, Catherine Lazor-Blanchet, Juana Doce, Eugenia Puentes, Dessislava Marinova, Nacho Aguilo, Carlos Martin
BACKGROUND: Tuberculosis remains one of the world's deadliest transmissible diseases despite widespread use of the BCG vaccine. MTBVAC is a new live tuberculosis vaccine based on genetically attenuated Mycobacterium tuberculosis that expresses most antigens present in human isolates of M tuberculosis. We aimed to compare the safety of MTBVAC with BCG in healthy adult volunteers. METHODS: We did this single-centre, randomised, double-blind, controlled phase 1 study at the Centre Hospitalier Universitaire Vaudois (CHUV; Lausanne, Switzerland)...
December 2015: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/26336365/how-important-is-hydrotherapy-effects-of-dynamic-action-of-hot-spring-water-as-a-rehabilitative-treatment-for-burn-patients-in-switzerland
#10
S Moufarrij, L Deghayli, W Raffoul, N Hirt-Burri, M Michetti, A de Buys Roessingh, M Norberg, L A Applegate
Burn rehabilitation using hydrotherapy can have multiple benefits for the burn patient. The therapy uses specific mineral enriched hot spring water and water jets with varied hydro-pressure to combat hypertrophy, inflammatory reaction signs, abnormal pigmentation, and, more specifically, redness and scarring. Standard operating procedures for burn rehabilitation have been developed and integrated into the Standard of Care at the CHUV hospital using localized hydro-mechanical stimulation of burn sites (20 minutes of alternating anatomical sites) followed by constant pressure large-bore and filiform showers targeting specific scarred areas...
December 31, 2014: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/26255495/-cern-medicis-medical-isotopes-collected-from-isolde-a-new-facility
#11
David Viertl, Franz Buchegger, John O Prior, Michel Forni, Philippe Morel, Osman Ratib, Bühler Léo H, Thierry Stora
CERN-MEDICIS is a facility dedicated to research and development in life science and medical applications. The research platform was inaugurated in October 2014 and will produce an increasing range of innovative isotopes using the proton beam of ISOLDE for fundamental studies in cancer research, for new imaging and therapy protocols in cell and animal models and for preclinical trials, possibly extended to specific early phase clinical studies (phase 0) up to phase I trials. CERN, the University Hospital of Geneva (HUG), the University Hospital of Lausanne (CHUV), the Swiss Institute for Experimental Cancer (ISREC) at Swiss Federal Institutes of Technology (EPFL) that currently support the project will benefit of the initial production that will then be extended to other centers...
June 17, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26062225/-non-invasive-brain-stimulation-for-parkinson-s-disease
#12
Gianandrea Gajo, Pierre Pollak, Christian Lüscher, David Benninger
Parkinson's disease (PD) is a major socio-economic burden increasing with the aging population. In advanced PD, the emergence of symptoms refractory to conventional therapy poses a therapeutic challenge. The success of deep brain stimulation (DBS) and advances in the understanding of the pathophysiology of PD have raised interest in non-invasive brain stimulation (NIBS) as an alternative therapeutic tool. NIBS could offer an alternative approach for patients at risk who are excluded from surgery and/or to treat refractory symptoms...
April 29, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25962227/-news-in-osteogenesis-imperfecta-from-research-to-clinical-management
#13
B Aubry-Rozier, S Unger, A Bregou, M Freymond Morisod, A Vaswani, P Scheider, L Bonafé
Osteogenesis imperfecta (OI) is a rare genetic disease. Today we are able to propose an adapted and efficient management to the patients with this rare disorder (and their families) thanks to a strong collaboration of clinicians and researchers. Recent knowledge regarding the genetics of OI permits an accurate diagnosis of the specific type of OI and its own molecular mechanism, a genetic counseling for family planning and prenatal diagnosis, and in addition more targeted therapeutic options. A specific support with re-education for patients with OI is necessary and efficient...
March 18, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25799664/-sport-medicine-consultation-for-adolescents
#14
Stéphane Tercier, Sarah Depallens, Pierre-Yves Zambelli, Anne-Emmanuelle Ambresin
Sport activity is a determinant of health and well-being for adolescents' psychological and physic development. Early detection of traumatic lesions or pathological condition among sportive adolescent in the light of their developmental stage is of outmost importance and is best done by an interdisciplinary team. This clinical management also aims at preventing consequences of inappropriate training. The CHUV has set-up a specific sports medicine outpatient consultation clinic for adolescents in the order to provide the best integrative management of young athletes...
January 14, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25474562/the-lausanne-institutional-biobank-a-new-resource-to-catalyse-research-in-personalised-medicine-and-pharmaceutical-sciences
#15
REVIEW
Vincent Mooser, Christine Currat
Breakthrough technologies which now enable the sequencing of individual genomes will irreversibly modify the way diseases are diagnosed, predicted, prevented and treated. For these technologies to reach their full potential requires, upstream, access to high-quality biomedical data and samples from large number of properly informed and consenting individuals and, downstream, the possibility to transform the emerging knowledge into a clinical utility. The Lausanne Institutional Biobank was designed as an integrated, highly versatile infrastructure to harness the power of these emerging technologies and catalyse the discovery and development of innovative therapeutics and biomarkers, and advance the field of personalised medicine...
2014: Swiss Medical Weekly
https://www.readbyqxmd.com/read/25143570/updating-the-pgmy-primers-and-probes-for-improved-detection-of-hpv68a-validation-of-version-2-of-the-pgmy-chuv-assay
#16
C Estrade, R Sahli
HPV68a is not efficiently detected by PCR with the PGMY primers. Version 2 of the PGMY-CHUV assay (PGv2) was developed from version 1 (PGv1) to evaluate HPV68-discordant results with the Anyplex II HPV28 assay. We now report that PGv2 is significantly more sensitive than PGv1 for HPV68a and as sensitive and specific for the other HPV genotypes during a 1-year prospective validation (n = 714 samples).
November 2014: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/24941689/-factors-influencing-the-return-to-work-after-transplantation-in-61-renal-or-liver-recipient
#17
S-M Praz-Christinaz, M Pascual, N Pilon, A Simcox, P Wild, B Danuser
The rate of return to work after transplantation is generally low, however this improves the quality of life of recipients. The aim of our study was to investigate the low rate after transplantation in 61 renal or liver patients followed at the Transplant Center (CTO) of the CHUV in Lausanne, and to analyse the occupational, individual and medical factors which may influence it. 39% of recipients returned to work after transplantation. The factors <being active pre-transplant), <with diploma> and <age <45 years olds were significantly related to return to work...
May 21, 2014: Revue Médicale Suisse
https://www.readbyqxmd.com/read/24834620/-inter-hospital-chuv-hug-medical-consensus-of-back-pain-management-its-application-in-care-pathways-within-chuv-of-lausanne
#18
Pierre de Goumoens, Stéphane Genevay, Enrico Tessitore, Maroun Zaarour, John Michael Duff, Antonio Faundez, Constantin Schizas, Maximilian Schindler, Davide Zoccatelli, Antonio Foletti, Iohn Norberg, Liliana Belgrand, Anne-Claude Griesser, Gerit Kulik
Back pain is a considerable economical burden in industrialised countries. Its management varies widely across countries, including Switzerland. Thus, the University Hospital and University of Lausanne (CHUV) recently improved intern processes of back pain care. In an already existing collaborative context, the two university hospitals in French-speaking Switzerland (CHUV, University Hospital of Geneva), felt the need of a medical consensus, based on a common concept. This inter-hospital consensus produced three decisional algorithms that bear on recent concepts of back pain found in literature...
April 30, 2014: Revue Médicale Suisse
https://www.readbyqxmd.com/read/24783736/-prevalence-of-early-and-late-dumping-after-gastric-bypass
#19
R Héraïef, V Giusti
Gastric bypass surgery is an effective treatment of obesity, bringing a significant weight loss and a major improvement of carbohydrate profile. However, in some patients, a deregulation in carbohydrate metabolism between insulin secretion and sensitivity is observed, whereupon early and late dumping happen. Their prevalence isn't well studied, although it seems that 10 to 20% of patients are affected. We've studied a cohort of 70 patients who undergone gastric bypass surgery at the CHUV. 18 (25.7%) patients have a positive anamnesis for early dumping and 10 (14...
March 26, 2014: Revue Médicale Suisse
https://www.readbyqxmd.com/read/24624733/-general-internal-medicine-in-hospital-practice-the-year-2013-put-into-perspective-by-residents
#20
Aude Giger, Luc Barberini, Philippe Bruchez, Julien Castioni, Florian Claude, Monica Cosma Rochat, David Gachoud, Mariangela Gagliano, Jens Greiser, Anne Mieville, Mathilde Rochat, Nathalie Rouiller-Larpin, David Santos, Julien Vaucher, Claudio Sartori
2013 was full of significant advances in all areas of medicine, which may have an impact on daily practice in general internal medicine. From salt and water restriction in heart failure to transfusion threshold in upper gastrointestinal bleeding and fecal infusion in Clostridium difficile colitis; from new data in resuscitation and persistent questions in palliative care and intensive care medicine, through pneumology, nephrology and endocrinology, the literature has been rich in new considerations. Each year, the residents of the Department of internal medicine of the University hospital of Vaud (CHUV) meet to share their most interesting readings...
January 22, 2014: Revue Médicale Suisse
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