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https://www.readbyqxmd.com/read/27913941/the-enigma-of-value-in-search-of-affordable-and-accessible-health-care
#1
EDITORIAL
Thomas D Szucs, Martina Weiss, Guido Klaus
In times of shrinking resources and pharmaceutical breakthrough situations, our value-assessing systems are stretched to their very limits. Assessing value is highly complex. Current value-assessment systems risk neglecting important factors, such as therapy duration, budget impact, or the importance of combination therapies. Especially when dealing with breakthrough therapies within high-prevalence indications, these factors play an important role in health care spending. When it comes to assessing value in Switzerland, the system is innovation and access-friendly; the price level of pharmaceutical products, however, is relatively high in comparison to neighboring countries...
December 2, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27912764/sbrt-for-centrally-localized-nsclc-what-is-too-central
#2
J Roesch, C Panje, F Sterzing, F Mantel, U Nestle, N Andratschke, M Guckenberger
PURPOSE: Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of peripheral lung tumors. However, the discussion on SBRT for centrally located tumors is controversial. This study evaluated current clinical practice regarding SBRT of centrally located lung tumors, to identify common fractionation schedules and commonly accepted contraindications for SBRT...
December 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27912037/avalanche-accidents-causing-fatalities-are-they-any-different-in-the-summer
#3
Mathieu Pasquier, Olivier Hugli, Alexandre Kottmann, Frank Techel
: Pasquier, Mathieu, Olivier Hugli, Alexandre Kottmann, and Frank Techel. Avalanche accidents causing fatalities: are they any different in the summer? High Alt Med Biol. 16:000-000, 2016. AIMS: This retrospective study investigated the epidemiology of summer avalanche accidents that occurred in Switzerland and caused at least one fatality between 1984 and 2014. Summer avalanche accidents were defined as those that occurred between June 1st and October 31st. RESULTS: Summer avalanches caused 21 (4%) of the 482 avalanches with at least one fatality occurring during the study period, and 40 (6%) of the 655 fatalities...
December 2, 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27912017/cyanobacteria-facilitate-parasite-epidemics-in-daphnia
#4
C Tellenbach, N Tardent, F Pomati, B Keller, N G Hairston, J Wolinska, P Spaak
The seasonal dominance of cyanobacteria in the phytoplankton community of lake ecosystems can have severe implications for higher trophic levels. For herbivorous zooplankton such as Daphnia, cyanobacteria have poor nutritional value and some species can produce toxins affecting zooplankton survival and reproduction. Here we present another, hitherto largely unexplored aspect of cyanobacteria, namely that they can increase Daphnia susceptibility to parasites. In a 12-yr monthly time-series analysis of the Daphnia community in Greifensee (Switzerland), we observed that cyanobacteria density correlated significantly with the epidemics of a common gut parasite of Daphnia, Caullerya mesnili, regardless of what cyanobacteria species was present or whether it was colonial or filamentous...
December 2016: Ecology
https://www.readbyqxmd.com/read/27911901/the-researchers-view-of-scientific-rigor-survey-on-the-conduct-and-reporting-of-in-vivo-research
#5
Thomas S Reichlin, Lucile Vogt, Hanno Würbel
Reproducibility in animal research is alarmingly low, and a lack of scientific rigor has been proposed as a major cause. Systematic reviews found low reporting rates of measures against risks of bias (e.g., randomization, blinding), and a correlation between low reporting rates and overstated treatment effects. Reporting rates of measures against bias are thus used as a proxy measure for scientific rigor, and reporting guidelines (e.g., ARRIVE) have become a major weapon in the fight against risks of bias in animal research...
2016: PloS One
https://www.readbyqxmd.com/read/27911892/authorization-of-animal-experiments-is-based-on-confidence-rather-than-evidence-of-scientific-rigor
#6
Lucile Vogt, Thomas S Reichlin, Christina Nathues, Hanno Würbel
Accumulating evidence indicates high risk of bias in preclinical animal research, questioning the scientific validity and reproducibility of published research findings. Systematic reviews found low rates of reporting of measures against risks of bias in the published literature (e.g., randomization, blinding, sample size calculation) and a correlation between low reporting rates and inflated treatment effects. That most animal research undergoes peer review or ethical review would offer the possibility to detect risks of bias at an earlier stage, before the research has been conducted...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27910795/i-did-eat-my-vegetables-agreement-between-parent-and-child-food-intake-diaries
#7
Natalie Rangelov, L Suzanne Suggs, Pedro Marques-Vidal
OBJECTIVE: To assess the level of agreement between children and their parents when reporting a child's food consumption. DESIGN: Cross-sectional study in which children and parents independently completed 7 d food diaries describing the foods and drinks the child consumed at every meal and snack. The association between child and parent reporting was assessed for nineteen food groups using Kendall's tau-b non-parametric correlations, Spearman's rank correlations, kappa coefficients and Lin's concordance measure of agreement...
December 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27909896/detection-of-shigella-sonnei-in-a-respiratory-specimen-in-a-patient-with-subacute-atypical-pneumonia
#8
Hiwa Nahid, Désirée Staub, Herbert Hächler, Werner C Albrich
BACKGROUND: Pneumonia caused by shigellosis with or without typical dysentery in immunocompetent patients is an uncommon entity. CASE REPORT: We describe a case of pneumonia in an immunocompetent, previously healthy middle-aged man from Switzerland without relevant travel history which was presumably caused by Shigella sonnei. He was originally admitted for suspected lung cancer. The clinical picture was remarkable as the patient presented with cough and purulent sputum production, but otherwise no classical signs of pneumonia...
December 1, 2016: Infection
https://www.readbyqxmd.com/read/27909385/biomarkers-of-inflammation-in-pediatric-arterial-ischemic-stroke
#9
COMMENT
Mary Dunbar, Aleksandra Mineyko
Investigators from Switzerland studied inflammatory markers in children and neonates with acute arterial ischemic stroke (AIS).
November 2016: Pediatric neurology briefs
https://www.readbyqxmd.com/read/27908488/accumulation-of-cadmium-and-uranium-in-arable-soils-in-switzerland
#10
Moritz Bigalke, Andrea Ulrich, Agnes Rehmus, Armin Keller
Mineral phosphorus (P) fertilizers contain contaminants that are potentially hazardous to humans and the environment. Frequent mineral P fertilizer applications can cause heavy metals to accumulate and reach undesirable concentrations in agricultural soils. There is particular concern about Cadmium (Cd) and Uranium (U) accumulation because these metals are toxic and can endanger soil fertility, leach into groundwater, and be taken up by crops. We determined total Cd and U concentrations in more than 400 topsoil and subsoil samples obtained from 216 agricultural sites across Switzerland...
November 28, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27906839/endothelin-contributes-to-the-blood-pressure-rise-triggered-by-hypoxia-in-severe-obstructive-sleep-apnea
#11
Christophe Janssen, Atul Pathak, Guido Grassi, Philippe van de Borne
BACKGROUND: Obstructive sleep apnea (OSA) is strongly correlated with an increased risk of systemic hypertension. However, the link between systemic hypertension and nocturnal apneas remains incompletely understood. Animal studies suggest an implication of the endothelin system. The aim of the present study is to determine if endogenous endothelin plays a role in the increase in blood pressure observed during hypoxic episodes in OSA patients, in addition to peripheral chemoreflex and neural sympathetic activation...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27906121/one-health-training-and-research-activities-in-western-europe
#12
REVIEW
Reina Sikkema, Marion Koopmans
INTRODUCTION: The increase in emerging human infectious diseases that have a zoonotic origin and the increasing resistance of microorganisms to antimicrobial drugs have shown the need for collaborations between the human, animal and environmental health sectors. The One Health concept increasingly receives recognition from policy makers and researchers all over the world. This overview compiled research and education activities in the area of One Health in Western Europe (Austria, Belgium, France, Germany, Italy, Iceland, Ireland, Liechtenstein, Luxembourg, Monaco, the Netherlands, Portugal, Scandinavia, Spain, Switzerland, and the United Kingdom (UK), with a focus on infectious diseases...
2016: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/27903880/aging-prisoners-views-on-healthcare-services-in-swiss-prisons
#13
Serena Galli, Wiebke Bretschneider, Bernice Simone Elger, Violet Handtke, David Shaw
OBJECTIVE: Due to the higher morbidity prevalent in the increasing older population, prisons are facing new challenges on a structural, ethical, and financial level. This study's goal was to explore older prisoners' views and experiences regarding the quality of medical services. METHOD: In this qualitative study, 35 semi-structured interviews were conducted with older inmates aged 50 years and above in 12 different prisons in the German-speaking (23 interviews) and the French-speaking parts (12 interviews) of Switzerland...
November 29, 2016: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/27903273/a-novel-quantitative-real-time-polymerase-chain-reaction-method-for-detecting-toxigenic-pasteurella-multocida-in-nasal-swabs-from-swine
#14
Simone Scherrer, Daniel Frei, Max Michael Wittenbrink
BACKGROUND: Progressive atrophic rhinitis (PAR) in pigs is caused by toxigenic Pasteurella multocida. In Switzerland, PAR is monitored by selective culture of nasal swabs and subsequent polymerase chain reaction (PCR) screening of bacterial colonies for the P. multocida toxA gene. A panel of 203 nasal swabs from a recent PAR outbreak were used to evaluate a novel quantitative real-time PCR for toxigenic P. multocida in porcine nasal swabs. RESULTS: In comparison to the conventional PCR with a limit of detection of 100 genome equivalents per PCR reaction, the real-time PCR had a limit of detection of 10 genome equivalents...
December 1, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27902717/could-google-trends-be-used-to-predict-methamphetamine-related-crime-an-analysis-of-search-volume-data-in-switzerland-germany-and-austria
#15
Alex Gamma, Roman Schleifer, Wolfgang Weinmann, Anna Buadze, Michael Liebrenz
OBJECTIVE: To compare the time trends of Google search interest in methamphetamine and criminal offences related to this drug. METHODS: Google Trends data for the search term "meth" was compared to methamphetamine-related crime statistics (incl. use, possession, and dealing) in Switzerland, Germany, and Austria for the years 2004-2016. Google data was availably monthly. Crime data was available yearly, and monthly values were imputed. RESULTS: On the country level, internet search trends for "meth" roughly paralleled relevant criminal activity...
2016: PloS One
https://www.readbyqxmd.com/read/27902382/the-genetic-diversity-and-phenotypic-associations-of-feline-caliciviruses-from-cats-in-switzerland
#16
Andrea M Spiri, Julien Thézé, Marina L Meli, Valentino Cattori, Alice Berger, Adolf Steinrigl, Oliver G Pybus, Regina Hofmann-Lehmann, Barbara Willi
Feline calicivirus (FCV) is a common viral pathogen in domestic cats worldwide. The variable regions of the capsid (VP1) gene of FCV have one of the highest recorded rates of molecular evolution. Understanding the genetic diversity and phylogeny of FCV is a prerequisite to exploring the epidemiology and pathogenesis of this virus and to the development of efficacious vaccine strategies. In this study, we undertook a nationwide molecular characterization of FCV using for the first time nearly complete capsid (VP1) gene sequences...
October 7, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901571/rare-donor-programs-in-switzerland-germany-and-austria
#17
Hein Hustinx, Sofia Lejon Crottet, Erwin A Scharberg, Christof Weinstock
No abstract text is available yet for this article.
June 2016: Immunohematology
https://www.readbyqxmd.com/read/27900183/severity-and-pattern-of-injuries-caused-by-the-traditional-swiss-team-sport-hornussen-first-retrospective-study-at-a-level-i-trauma-centre-in-switzerland
#18
Volkmar Waterkamp, Meret Ricklin, Benoît Schaller, Konstantinos Katsoulis, Aristomenis Exadaktylos
BACKGROUND: This article addresses typical injury patterns related to the traditional Swiss team sport of Hornussen. A small plastic disk is struck with a special elastic racket and then intercepted in the field. Severe injuries have occasionally been reported. We present a systematic review of all cases of Hornussen injuries treated in the University Hospital of Bern from 2000 to 2014. METHODS: To assess the frequency, type and outcome of Hornussen injuries, we performed a database search of all inpatient and outpatient cases related to Hornussen and that were admitted to and/or treated in Bern University Hospital from 2000 to 2014...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900164/prevalence-of-depression-and-anxiety-in-top-level-male-and-female-football-players
#19
Astrid Junge, Nina Feddermann-Demont
BACKGROUND: Scientific studies on the prevalence of mental health problems in elite athletes are rare, and most have had considerable methodological limitations, such as low response rate and heterogeneous samples. AIMS: To evaluate the prevalence of depression and anxiety in top-level football players in comparison to the general population, and to analyse potential risk factors. METHODS: Players of all first league (FL) and of four U-21 football teams in Switzerland were asked to answer a questionnaire on player's characteristics, the Centre of Epidemiologic Studies Depression Scale (CES-D) and the Generalized Anxiety Disorder (GAD-7) scale...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27896706/anesthetics-and-outcome-in-status-epilepticus-a-matched-two-center-cohort-study
#20
Raoul Sutter, Gian Marco De Marchis, Saskia Semmlack, Peter Fuhr, Stephan Rüegg, Stephan Marsch, Wendy C Ziai, Peter W Kaplan
BACKGROUND: The use of anesthetics has been linked to poor outcome in patients with status epilepticus (SE). This association, however, may be confounded, as anesthetics are mostly administered in patients with more severe SE and critical illnesses. OBJECTIVE: To minimize treatment-selection bias, we assessed the association between continuously administered intravenous anesthetic drugs (IVADs) and outcome in SE patients by a matched two-center study design. METHODS: This cohort study was performed at the Johns Hopkins Bayview Medical Center, Baltimore, MD, USA and the University Hospital Basel, Basel, Switzerland...
November 29, 2016: CNS Drugs
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