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Katharine G Lunny, Yanice Benitez, Yishai Albeck, Daniel Strasser, John F Stanton, Robert E Continetti
In an effort to characterize the electronic states of ethylenedione, OCCO, photoelectron-photofragment coincidence (PPC) spectroscopy was applied to measure anions at m/z 56 and 57 using a pulsed discharge of glyoxal vapor and N2 O. PPC measurements at a photon energy of 3.20 eV yield photoelectron spectra in coincidence with either neutral photofragments or stable neutral products. The measurements showed that primarily stable neutral products were formed, with photoelectron spectra consistent with the oxyallyl diradical, C3 H4 O, and acetone enolate radical, C3 H5 O...
May 4, 2018: Angewandte Chemie
Ben B Shen, Yanice Benitez, Katharine G Lunny, Robert E Continetti
Photoelectron-photofragment coincidence (PPC) spectra of ozonide, O3(-), were measured at 388 nm (Ehν = 3.20 eV) using a newly constructed cryogenic octopole accumulation trap coupled to a PPC spectrometer. The photoelectron spectra reveal three processes consisting of a stable photodetachment channel, and two distinct photodissociation pathways yielding (1) O2 + O(-) or (2) O + O2(-). The first photodissociation pathway is observed in the PPC spectra by photodetachment of the O(-) product by a second photon, and produces electronically excited O2((1)Δg)...
September 7, 2017: Journal of Chemical Physics
Jillian P Rhoads, John R Lukens, Ashley J Wilhelm, Jared L Moore, Yanice Mendez-Fernandez, Thirumala-Devi Kanneganti, Amy S Major
Oxidized low-density lipoprotein (oxLDL) is known to activate inflammatory responses in a variety of cells, especially macrophages and dendritic cells. Interestingly, much of the oxLDL in circulation is complexed to Abs, and these resulting immune complexes (ICs) are a prominent feature of chronic inflammatory disease, such as atherosclerosis, type-2 diabetes, systemic lupus erythematosus, and rheumatoid arthritis. Levels of oxLDL ICs often correlate with disease severity, and studies demonstrated that oxLDL ICs elicit potent inflammatory responses in macrophages...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
J Mauricio Sánchez, Margaret A Yanics, Patricia Wilson, Amit Doshi, Thomas Kurian, Stephen Pieper
BACKGROUND: Ablation procedures for arrhythmias have increased in frequency and complexity over the last decade. Improvements in technology have allowed for less reliance on fluoroscopy to guide these procedures. Ablation without fluoroscopy has been reported in small cohorts. We report a single center experience of fluoroless ablation after adoption of this technique for all endovascular ablations. METHODS: This retrospective study evaluated 107 consecutive patients who underwent a catheter ablation procedure for an atrial or ventricular arrhythmias after adoption of a completely fluoroless technique...
March 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Zhou Lu, Yih Chung Chang, Yanice Benitez, Zhihong Luo, Adel Ben Houria, Tarek Ayari, Muneerah Mogren Al Mogren, M Hochlaf, W M Jackson, C Y Ng
The state-to-state photodissociation of CO2 is investigated in the VUV range of 11.94-12.20 eV by using two independently tunable vacuum ultraviolet (VUV) lasers and the time-sliced velocity-map-imaging-photoion (VMI-PI) method. The spin-allowed CO(X(1)Σ(+); v = 0-18) + O((1)D) and CO(X(1)Σ(+); v = 0-9) + O((1)S) photoproduct channels are directly observed from the measurement of time-sliced VMI-PI images of O((1)D) and O((1)S). The total kinetic energy release (TKER) spectra obtained based on these VMI-PI images shows that the observed energetic thresholds for both the O((1)D) and O((1)S) channels are consistent with the thermochemical thresholds...
May 7, 2015: Physical Chemistry Chemical Physics: PCCP
Nicolas Martin, Edouard Kraffe, Fabienne Le Grand, Yanic Marty, Dominique P Bureau, Helga Guderley
Although dietary lipid quality markedly affects fatty acid (FA) composition of mitochondrial membranes from rainbow trout red muscle (Oncorhynchus mykiss), mitochondrial processes are relatively unchanged. As certain classes of phospholipids interact more intimately with membrane proteins than others, we examined whether specific phospholipid classes from these muscle mitochondria were more affected by dietary FA composition than others. To test this hypothesis, we fed trout with two diets differing only in their FA composition: Diet 1 had higher levels of 18:1n-9 and 18:2n-6 than Diet 2, while 22:6n-3 and 22:5n-6 were virtually absent from Diet 1 and high in Diet 2...
January 2015: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
Zhou Lu, Yih Chung Chang, Hong Gao, Yanice Benitez, Yu Song, C Y Ng, W M Jackson
We present a generally applicable experimental method for the direct measurement of nascent spin-orbit state distributions of atomic photofragments based on the detection of vacuum ultraviolet (VUV)-excited autoionizing-Rydberg (VUV-EAR) states. The incorporation of this VUV-EAR method in the application of the newly established VUV-VUV laser velocity-map-imaging-photoion (VMI-PI) apparatus has made possible the branching ratio measurement for correlated spin-orbit state resolved product channels, CO(ã(3)Π; v) + O((3)P0,1,2) and CO(X̃(1)Σ(+); v) + O((3)P0,1,2), formed by VUV photoexcitation of CO2 to the 4s(10 (1)) Rydberg state at 97,955...
June 21, 2014: Journal of Chemical Physics
Fabienne Le Grand, Philippe Soudant, Ahmed Siah, Réjean Tremblay, Yanic Marty, Edouard Kraffe
In a previous study we compared lipid composition and functional parameters of circulating cells from Cerastoderma edule affected or not by disseminated neoplasia (neoplastic cells vs hemocytes) (Le Grand et al. Chem Phys Lipids 167:9-20 2013). Neoplastic cells presented morpho-functional modifications concomitant to striking membrane lipid alterations: the proportion of particular plasmalogen molecular species was drastically decreased. We wanted to test whether this pattern was representative of bivalve neoplastic cells...
August 2014: Lipids
Fabienne Le Grand, Philippe Soudant, Yanic Marty, Nelly Le Goïc, Edouard Kraffe
Membrane lipid composition and morpho-functional parameters were investigated in circulating cells of the edible cockle (Cerastoderma edule) affected by disseminated neoplasia (neoplastic cells) and compared to those from healthy cockles (hemocytes). Membrane sterol levels, phospholipid (PL) class and subclass proportions and their respective fatty acid (FA) compositions were determined. Morpho-functional parameters were evaluated through total hemocyte count (THC), mortality rate, phagocytosis ability and reactive oxygen species (ROS) production...
February 2013: Chemistry and Physics of Lipids
Antoine Perhirin, Edouardb Kraffe, Yanic Marty, François Quentel, Philippe Elies, Frederic Gloaguen
Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL)/phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. At low ionic strength, we observed two redox-active subpopulations characterized by distinct values of potential (E1/2) and electron transfer rate constant (k(ET)). At high ionic strength, only one subpopulation was detected, consistent with the existence of very stable cyt c-CL adducts, most probably formed by hydrophobic interactions between the protein and the fatty acid (FA) chains carried by CL...
March 2013: Biochimica et Biophysica Acta
Maksim Agaronov, Soma G Karak, Yanice Maldonado, Janice Tetreault, Jaber Aslanzadeh
The need for rapid diagnosis of Clostridium difficile (C. difficile) associated infection in a clinical microbiology laboratory has provided the stimulus for new diagnostic tests and testing protocols. A two-test algorithm has been proposed using assays such as Quik Chek Complete, which detects both C. difficile glutamate dehydrogenase (GDH) and C. difficile toxins A and B, followed by reflex testing of samples having inconclusive results (GDH positive and toxin negative) with PCR for identification of toxin gene specific DNA...
2012: Annals of Clinical and Laboratory Science
Curtis L Gabriel, Patricia B Smith, Yanice V Mendez-Fernandez, Ashley J Wilhelm, Audrey Musi Ye, Amy S Major
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against self-antigens such as double-stranded DNA and phospholipids. Classical comorbidities of SLE include glomerulonephritis, infection, cardiovascular disease, arthritis, skin disorders, and neurological disease. In addition to these classical comorbidities, there is emerging evidence that SLE patients are at higher risk of developing insulin resistance and other components of the metabolic syndrome...
December 1, 2012: American Journal of Physiology. Endocrinology and Metabolism
Lan Wu, Vrajesh V Parekh, Curtis L Gabriel, Deanna P Bracy, Pamela A Marks-Shulman, Robyn A Tamboli, Sungjune Kim, Yanice V Mendez-Fernandez, Gurdyal S Besra, Jefferson P Lomenick, Brandon Williams, David H Wasserman, Luc Van Kaer
Obesity triggers a low-grade systemic inflammation, which plays an important role in the development of obesity-associated metabolic diseases. In searching for links between lipid accumulation and chronic inflammation, we examined invariant natural killer T (iNKT) cells, a subset of T lymphocytes that react with lipids and regulate inflammatory responses. We show that iNKT cells respond to dietary lipid excess and become activated before or at the time of tissue recruitment of inflammatory leukocytes, and that these cells progressively increase proinflammatory cytokine production in obese mice...
May 8, 2012: Proceedings of the National Academy of Sciences of the United States of America
Kevin D Pavelko, Yanice Mendez-Fernandez, Michael P Bell, Michael J Hansen, Aaron J Johnson, Chella S David, Moses Rodriguez, Larry R Pease
Structural diversity in the peptide binding sites of the redundant classical MHC antigen presenting molecules is strongly selected in humans and mice. Although the encoded antigen presenting molecules overlap in antigen presenting function, differences in polymorphism at the MHC I A, B and C loci in humans and higher primates indicate these loci are not functionally equivalent. The structural basis of these differences is not known. We hypothesize that classical class I loci differ in their ability to direct effective immunity against intracellular pathogens...
February 2012: PLoS Pathogens
Marine Déon, Yanice Bourré, Stéphanie Gimenez, Angélique Berger, Daniel Bieysse, Frédéric de Lamotte, Joël Poncet, Véronique Roussel, François Bonnot, Gérald Oliver, Jérôme Franchel, Marc Seguin, Thierry Leroy, Patricia Roeckel-Drevet, Valérie Pujade-Renaud
Corynespora Leaf Fall (CLF) is a major disease of rubber tree (Hevea brasiliensis) caused by the Ascomycota Corynespora cassiicola. Here we describe the cloning and characterization of a gene encoding cassiicolin (Cas), a glycosylated cystein-rich small secreted protein (SSP) identified as a potential CLF disease effector in rubber tree. Three isolates with contrasted levels of aggressiveness were analyzed comparatively. The cassiicolin gene was detected - and the toxin successfully purified - from the isolates with high and medium aggressiveness (CCP and CCAM3 respectively) but not from the isolate with the lowest aggressiveness (CCAM1), suggesting the existence of a different disease effector in the later...
April 2012: Plant Science: An International Journal of Experimental Plant Biology
Yanice V Méndez-Fernández, Amy S Major
No abstract text is available yet for this article.
February 2012: Arteriosclerosis, Thrombosis, and Vascular Biology
Sander I van Leuven, Yanice V Mendez-Fernandez, Ashley J Wilhelm, Nekeithia S Wade, Curtis L Gabriel, John J Kastelein, Erik S Stroes, Paul P Tak, Amy S Major
RATIONALE: Recent clinical and preclinical studies have demonstrated that systemic lupus erythematosus (SLE) is associated with an increased risk for cardiovascular disease (CVD). However, unlike in the general population, little is known regarding the efficacy of atheroprotective interventions in patients with SLE. The current study aims to determine the benefit of lymphocyte inhibition on reducing the atherosclerotic burden in SLE-susceptible LDLr-deficient mice. METHODS: Female LDLr(-/-) mice were lethally irradiated and reconstituted with bone marrow from C57Bl/6 mice (LDLr...
March 2012: Annals of the Rheumatic Diseases
Kevin D Pavelko, Megan A Girtman, Yoshihiro Mitsunaga, Yanice V Mendez-Fernandez, Michael P Bell, Michael J Hansen, Kathleen S Allen, Moses Rodriguez, Larry R Pease
The induction of sterilizing T-cell responses to tumors is a major goal in the development of T-cell vaccines for treating cancer. Although specific components of anti-viral CD8+ immunity are well characterized, we still lack the ability to mimic viral CD8+ T-cell responses in therapeutic settings for treating cancers. Infection with the picornavirus Theiler's murine encephalomyelitis virus (TMEV) induces a strong sterilizing CD8+ T-cell response. In the absence of sterilizing immunity, the virus causes a persistent infection...
2011: PloS One
Fabienne Le Grand, Edouard Kraffe, Yanic Marty, Ludovic Donaghy, Philippe Soudant
The detailed sterol (free sterol proportions and compositions) and phospholipid (PL) compositions (relative proportions of PL classes and subclasses and their respective fatty acid (FA) compositions) of hemocyte membranes were investigated in two bivalve mollusks: the Pacific oyster Crassostrea gigas and the Manila clam Ruditapes philippinarum. Hemocyte membrane lipids of both species revealed similar general composition: i) their free sterol/PL ratio was above 0.4 and ii) their PL were predominated by the diacyl+alkyl forms of glycerophosphatidylcholine (PC), the plasmalogen form of glycerophosphatidylethanolamine (PE) and ceramide aminoethylphosphonate (CAEP)...
August 2011: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Yanice V Mendez-Fernandez, Bonnie G Stevenson, Cody J Diehl, Nicole A Braun, Nekeithia S Wade, Roman Covarrubias, Sander van Leuven, Joseph L Witztum, Amy S Major
BACKGROUND: Atherosclerosis is widely accepted as an inflammatory disease involving both innate and adaptive immunity. B cells and/or antibodies have previously been shown to play a protective role against atherosclerosis. Aside from their ability to bind to antigens, antibodies can influence inflammatory responses by interacting with various Fcγ receptors on the surface of antigen presenting cells. Although studies in mice have determined that stimulatory Fcγ receptors contribute to atherosclerosis, the role of the inhibitory Fcγ receptor IIb (FcγRIIb) has only recently been investigated...
January 2011: Atherosclerosis
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