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https://www.readbyqxmd.com/read/28092806/life-cycle-ultrastructure-and-phylogeny-of-parvilucifera-corolla-sp-nov-alveolata-perkinsozoa-a-parasitoid-of-dinoflagellates
#1
Albert Reñé, Elisabet Alacid, Rosa Isabel Figueroa, Francisco Rodríguez, Esther Garcés
Recent studies of marine protists have revealed parasites to be key components of marine communities. Here we describe a new species of the parasitoid genus Parvilucifera that was observed infecting the dinoflagellate Durinskia baltica in salt marshes of the Catalan coast (NW Mediterranean). In parallel, the same species was detected after the incubation of seawater from the Canary Islands (Lanzarote, NE Atlantic). The successful isolation of strains from both localities allowed description of the life cycle, ultrastructure, and phylogeny of the species...
December 13, 2016: European Journal of Protistology
https://www.readbyqxmd.com/read/28092805/circumstantial-evidence-of-life-history-events-in-loricate-choanoflagellates
#2
Helge Abildhauge Thomsen, Jette Buch Østergaard
Sex is found in all major eukaryotic groups of organisms. It has been known for some time that the choanoflagellates also possess the genes involved in meiosis and a full sexual cycle was also recently accounted for in Salpingoeca rosetta. With reference to the loricate choanoflagellates the current status is that only circumstantial evidence, from wild material of Bicosta spinifera, exists in favour of documenting division patterns that go beyond plain asexual division, and that has the potential to represent stages in a sexual life cycle...
December 27, 2016: European Journal of Protistology
https://www.readbyqxmd.com/read/28092742/short-term-in-vivo-exposure-to-graphene-oxide-can-cause-damage-to-the-gut-and-testis
#3
Marta Dziewięcka, Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
Graphene oxide (GO) has unique physicochemical properties and also has a potentially widespread use in every field of daily life (industry, science, medicine). Demand for nanotechnology is growing every year, and therefore many aspects of its toxicity and biocompatibility still require further clarification. This research assesses the in vivo toxicity of pure and manganese ion-contaminated GO that were administrated to Acheta domesticus with food (at 200mgkg(-1) of food) throughout their ten-day adult life...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28092214/treatment-of-delta-hepatitis-today-and-in-the-future-a-review
#4
Ibrahim Halil Bahcecioglu, Abdurrahman Sahin
Hepatitis delta virus (HDV) is a defective satellite virus and propagates in the presence of Hepatitis B virus (HBV) surface antigen (HBsAg). Approximately 5% of the people who infected with HBV are also infected with HDV. Chronic hepatitis caused by delta is the most severe form of chronic viral hepatitis including accelerated fibrosis, liver decompensation and development of hepatocellular carcinoma. Interferon-based therapies still remain the only treatment option of the hepatitis delta. The beneficiary effects of the interferon-based therapies, however, stop frequently with termination of the given therapy and relapse rate is very high...
January 16, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28092171/a-pangenotypic-single-tablet-regimen-of-sofosbuvir-velpatasvir-for-the-treatment-of-chronic-hepatitis-c-infection
#5
Ilan S Weisberg, Ira M Jacobson
Hepatitis C virus (HCV) infects nearly 170 million people worldwide and is a leading cause of progressive liver damage, cirrhosis, and hepatocellular carcinoma. Curative therapies have historically relied on interferon-based treatments and were limited by significant toxicity and poor response rates, particularly among patients with prior treatment failure and advanced hepatic fibrosis. The recent advent of direct acting antiviral (DAA) agents which target key steps in the HCV viral life cycle has transformed the landscape of HCV treatment by offering highly effective and well tolerated interferon-free treatments...
January 16, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28091931/identifying-anti-host-effectors-in-photorhabdus
#6
Andrea J Dowling
The death of the insect host is an essential part of the life cycle of Photorhabdus, and as a result, this bacterium comes equipped with a dazzlingly large array of toxins and virulence factors that ensure rapid insect death. Elucidation of the key players in insect infection and mortality has therefore proved difficult using traditional microbiological techniques such as individual gene knockouts due to the high level of functional redundancy displayed by Photorhabdus virulence factors. Thus, knockout of any individual toxin gene may serve to delay time to death but not to render the bacteria avirulent due to the continued presence of an array of other toxins and virulence factors in the single-gene mutant...
December 28, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28091679/sustainability-of-renewable-fuel-infrastructure-a-screening-lca-case-study-of-anticorrosive-graphene-oxide-epoxy-liners-in-steel-tanks-for-the-storage-of-biodiesel-and-its-blends
#7
Govinda Chilkoor, Venkata K K Upadhyayula, Venkataramana Gadhamshetty, Nikhil Koratkar, Mats Tysklind
Biodiesel is a widely used fuel that meets the renewable fuel standards developed under the Energy Policy Act of 2005. However, biodiesel is known to pose a series of abiotic and biotic corrosion risks to storage tanks. A typical practice (incumbent system) used to protect the tanks from these risks include (i) coating the interior surface of the tank with a solvent-free epoxy (SFE) liner, and (ii) adding a biocide to the tank. Herein, we present a screening-level life-cycle assessment study to compare the environmental performance of a graphene oxide (GO)-epoxy (GOE) liner with the incumbent system...
January 16, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28090088/the-%C3%AE-trcp-fbxw2-skp2-axis-regulates-lung-cancer-cell-growth-with-fbxw2-acting-as-a-tumour-suppressor
#8
Jie Xu, Weihua Zhou, Fei Yang, Guoan Chen, Haomin Li, Yongchao Zhao, Pengyuan Liu, Hua Li, Mingjia Tan, Xiufang Xiong, Yi Sun
β-TrCP and SKP2 are two well-studied F-box proteins, which often act as oncogenes. Whether and how they communicate with each other is unknown. Here we report that FBXW2, a poorly characterized F-box, is a substrate of β-TrCP1 and an E3 ligase for SKP2. While β-TrCP1 promotes FBXW2 ubiquitylation and shortens its half-life, FBXW2 does the same to SKP2. FBXW2 has tumour suppressor activity against lung cancer cells and blocks oncogenic function of both β-TrCP1 and SKP2. The levels of β-TrCP1-FBXW2-SKP2 are inversely correlated during cell cycle with FBXW2 and β-TrCP/SKP2 being high or low, respectively, in arrested cells, whereas the opposite is true in proliferating cells...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089978/rituximab-retreatment-in-rheumatoid-arthritis-in-a-real-life-cohort-data-from-the-cererra-collaboration
#9
Katerina Chatzidionysiou, Elisabeth Lie, Galina Lukina, Merete L Hetland, Ellen-Margrethe Hauge, Karel Pavelka, Cem Gabay, Almut Scherer, Dan Nordström, Helena Canhao, Maria José Santos, Matija Tomsic, Ziga Rotar, M Victoria Hernández, Juan Gomez-Reino, Ioan Ancuta, Tore K Kvien, Ronald van Vollenhoven
OBJECTIVE: Several aspects of rituximab (RTX) retreatment in rheumatoid arthritis (RA) need to be further elucidated. The aim of this study was to describe the effect of repeated courses of RTX on disease activity and to compare 2 retreatment strategies, fixed-interval versus on-flare retreatment, in a large international, observational, collaborative study. METHODS: In the first analysis, patients with RA who received at least 4 cycles with RTX were included. In the second analysis, patients who received at least 1 RTX retreatment and for whom information about the strategy for retreatment was available were identified...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089376/chemotherapy-completion-in-elderly-women-with-ovarian-primary-peritoneal-or-fallopian-tube-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#10
Vivian E von Gruenigen, Helen Q Huang, Jan H Beumer, Heather A Lankes, William Tew, Thomas Herzog, Arti Hurria, Robert S Mannel, Tina Rizack, Lisa M Landrum, Peter G Rose, Ritu Salani, William H Bradley, Thomas J Rutherford, Robert V Higgins, Angeles Alvarez Secord, Gini Fleming
PURPOSE: A simple measure to predict chemotherapy tolerance in elderly patients would be useful. We prospectively tested the association of baseline Instrumental Activities of Daily Living (IADL) score with ability to complete 4 cycles of first line chemotherapy without dose reductions or >7days delay in elderly ovarian cancer patients. PATIENTS AND METHODS: Patients' age ≥70 along with their physicians chose between two regimens: CP (Carboplatin AUC 5, Paclitaxel 135mg/m(2)) or C (Carboplatin AUC 5), both given every 3weeks either after primary surgery or as neoadjuvant chemotherapy (NACT) with IADL and quality of life assessments performed at baseline, pre-cycle 3, and post-cycle 4...
January 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28089203/carbon-footprint-and-energy-use-of-food-waste-management-options-for-fresh-fruit-and-vegetables-from-supermarkets
#11
Mattias Eriksson, Johanna Spångberg
Food waste is a problem with economic, environmental and social implications, making it both important and complex. Previous studies have addressed food waste management options at the less prioritised end of the waste hierarchy, but information on more prioritised levels is also needed when selecting the best available waste management options. Investigating the global warming potential and primary energy use of different waste management options offers a limited perspective, but is still important for validating impacts from the waste hierarchy in a local context...
January 11, 2017: Waste Management
https://www.readbyqxmd.com/read/28088851/monitoring-the-reaction-process-during-the-s2%C3%A2-s3-transition-in-photosynthetic-water-oxidation-using-time-resolve-infrared-spectroscopy
#12
Hiroki Sakamoto, Tatsuki Shimizu, Ryo Nagao, Takumi Noguchi
Photosynthetic water oxidation performed at the Mn4CaO5 cluster in photosystem II plays a crucial role in energy production as electron and proton sources necessary for CO2 fixation. Molecular oxygen, a byproduct, is a source of the oxygenic atmosphere that sustains life on earth. However, the molecular mechanism of water oxidation is not yet well understood. In the reaction cycle of intermediates called S states, the S2→S3 transition is particularly important; it consists of multiple processes of electron transfer, proton release, and water insertion, and generates an intermediate leading to O-O bond formation...
January 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28088688/randomized-phase-iii-study-to-assess-efficacy-and-safety-of-adjuvant-capox-with-or-without-bevacizumab-in-patients-after-resection-of-colorectal-liver-metastases-hepatica-study
#13
Nikol Snoeren, Richard van Hillegersberg, Sander B Schouten, Andre M Bergman, Erikv van Werkhoven, Otilia Dalesio, Rob A E M Tollenaar, Henk M Verheul, Joost van der Sijp, Inne H M Borel Rinkes, E E Voest
Bevacizumab is a humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF). Recurrence after resection of colorectal liver metastases (CRLMs), presumably caused by VEGF-mediated outgrowth of micrometastases, might decrease when VEGF is inhibited. This study examines the efficacy and safety of adding bevacizumab to an adjuvant regimen of CAPOX in patients undergoing radical resection for their CRLMs. Patients with resected CRLMs were randomized after surgery to receive CAPOX and bevacizumab (arm A) or CAPOX alone (arm B) as adjuvant treatment...
January 12, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28088546/product-vs-corporate-carbon-footprint-some-methodological-issues-a-case-study-and-review-on-the-wine-sector
#14
Alejandra Navarro, Rita Puig, Pere Fullana-I-Palmer
Carbon footprint (CF) is nowadays one of the most widely used environmental indicators. The scope of the CF assessment could be corporate (when all production processes of a company are evaluated, together with upstream and downstream processes following a life cycle approach) or product (when one of the products is evaluated throughout its life cycle). Our hypothesis was that usually product CF studies (PCF) collect corporate data, because it is easier for companies to obtain them than product data. Six main methodological issues to take into account when collecting corporate data to be used for PCF studies were postulated and discussed in the present paper: fugitive emissions, credits from waste recycling, use of "equivalent factors", reference flow definition, accumulation and allocation of corporate values to minor products...
January 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28088354/uncovering-oxysterol-binding-protein-osbp-as-a-target-of-the-anti-enteroviral-compound-ttp-8307
#15
Lucian Albulescu, Joëlle Bigay, Bishyajit Biswas, Marion Weber-Boyvat, Cristina M Dorobantu, Leen Delang, Hilde M van der Schaar, Young-Sik Jung, Johan Neyts, Vesa M Olkkonen, Frank J M van Kuppeveld, Jeroen R P M Strating
The genus Enterovirus (e.g. poliovirus, coxsackievirus, rhinovirus) of the Picornaviridae family of positive-strand RNA viruses includes many important pathogens linked to a range of acute and chronic diseases for which no approved antiviral therapy is available. Targeting a step in the life cycle that is highly conserved provides an attractive strategy for developing broad-range inhibitors of enterovirus infection. A step that is currently explored as a target for the development of antivirals is the formation of replication organelles, which support replication of the viral genome...
January 11, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28088120/3d-architecture-of-a-graphene-comoo4-composite-for-asymmetric-supercapacitors-usable-at-various-temperatures
#16
Yaru Jiang, Xin Zheng, Xiaoqin Yan, Yong Li, Xuan Zhao, Yue Zhang
Designing and optimizing the electrode materials and studying the electrochemical performance or cycle life of the supercapacitor under different working conditions are crucial to its practical application. Herein, we proposed a rational design of 3D-graphene/CoMoO4 nanoplates by a facile two-step hydrothermal method. Owing to the high electron transfer rate of graphene and the high activity of the CoMoO4 nanoplates, the three-dimensional electrode architectures achieved remarkable electrochemical performances with high areal specific capacitance (1255...
January 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088070/fatigue-life-of-bovine-meniscus-under-longitudinal-and-transverse-tensile-loading
#17
Jaremy J Creechley, Madison E Krentz, Trevor J Lujan
The knee meniscus is composed of a fibrous extracellular matrix that is subjected to large and repeated loads. Consequently, the meniscus is frequently torn, and a potential mechanism for failure is fatigue. The objective of this study was to measure the fatigue life of bovine meniscus when applying cyclic tensile loads either longitudinal or transverse to the principal fiber direction. Fatigue experiments consisted of cyclic loads to 60%, 70%, 80% or 90% of the predicted ultimate tensile strength until failure occurred or 20,000 cycles was reached...
December 27, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28088060/life-cycle-analysis-of-mitigation-methodologies-for-railway-rolling-noise-and-groundbourne-vibration
#18
Mariana Valente Tuler, Sakdirat Kaewunruen
Negative outcomes such as noise and vibration generated by railways have become a challenge for both industry and academia in order to guarantee that the railway system can accomplish its purposes and at the same time provide comfort for users and people living in the neighbourhood along the railway corridor. The research interest on this field has been increasing and the advancement in noise and vibration mitigation methodologies can be observed using various engineering techniques that are constantly put into test to solve such effects...
January 11, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28087946/invasion-of-host-cells-and-tissues-by-uropathogenic-bacteria
#19
Adam J Lewis, Amanda C Richards, Matthew A Mulvey
Within the mammalian urinary tract uropathogenic bacteria face many challenges, including the shearing flow of urine, numerous antibacterial molecules, the bactericidal effects of phagocytes, and a scarcity of nutrients. These problems may be circumvented in part by the ability of uropathogenic Escherichia coli and several other uropathogens to invade the epithelial cells that line the urinary tract. By entering host cells, uropathogens can gain access to additional nutrients and protection from both host defenses and antibiotic treatments...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28087763/circadian-kinetics-of-cell-cycle-progression-in-adult-neurogenic-niches-of-a-diurnal-vertebrate
#20
Veronica Akle, Alexander J Stankiewicz, Vasili Kharchenko, Lili Yu, Peter V Kharchenko, Irina V Zhdanova
: The circadian system may regulate adult neurogenesis via intracellular molecular clock mechanisms or by modifying the environment of neurogenic niches, with daily variation in growth factors or nutrients depending on the animal's diurnal or nocturnal life-style. In a diurnal vertebrate, zebrafish, we studied circadian distribution of immunohistochemical markers of the cell division cycle (CDC) in five of the sixteen neurogenic niches of adult brain, the dorsal telencephalon, habenula, preoptic area, hypothalamus and cerebellum...
January 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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