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https://www.readbyqxmd.com/read/27933565/kshv-strategies-for-host-dsdna-sensing-machinery
#1
REVIEW
Hang Gao, Yanyan Song, Chengrong Liu, Qiming Liang
The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling...
December 5, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933402/quality-of-life-evaluation-during-platinum-based-neoadjuvant-chemotherapies-for-urothelial-carcinoma
#2
Ken Fukushi, Takuma Narita, Shingo Hatakeyama, Hayato Yamamoto, Osamu Soma, Teppei Matsumoto, Yuki Tobisawa, Tohru Yoneyama, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
BACKGROUND: Although quality of life (QOL) is one of the most important considerations in patients treated with anticancer therapies, desirable regimens for neoadjuvant chemotherapy including QOL in locally advanced urothelial carcinoma remain unclear. The present study evaluated the influence of neoadjuvant platinum-based chemotherapy on QOL in patients with locally advanced urothelial carcinoma. METHODS: Between June 2013 and March 2016, 83 urothelial carcinoma patients who received two courses of neoadjuvant chemotherapy were enrolled in this prospective observational study...
December 8, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27933392/leishmania-infection-painful-or-painless
#3
REVIEW
Sergio M Borghi, Victor Fattori, Ivete Conchon-Costa, Phileno Pinge-Filho, Wander R Pavanelli, Waldiceu A Verri
The complex life cycle and immunopathological features underpinning the interaction of Leishmania parasites and their mammalian hosts poses frequent poorly explored and inconclusively resolved questions. The altered nociceptive signals over the course of leishmaniasis remain an intriguing issue for nociceptive and parasitology researchers. Experimental investigations have utilized behavioral, morphological, and neuro-immune approaches in the study of experimental cutaneous leishmaniasis (CL). The data generated indicates new venues for the study of the pathological characteristics of nociceptive processing in this parasitic disease...
December 9, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27933262/software-project-management-tools-in-global-software-development-a-systematic-mapping-study
#4
Saad Yasser Chadli, Ali Idri, Joaquín Nicolás Ros, José Luis Fernández-Alemán, Juan M Carrillo de Gea, Ambrosio Toval
Global software development (GSD) which is a growing trend in the software industry is characterized by a highly distributed environment. Performing software project management (SPM) in such conditions implies the need to overcome new limitations resulting from cultural, temporal and geographic separation. The aim of this research is to discover and classify the various tools mentioned in literature that provide GSD project managers with support and to identify in what way they support group interaction. A systematic mapping study has been performed by means of automatic searches in five sources...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27932586/nup100-regulates-saccharomyces-cerevisiae-replicative-life-span-by-mediating-the-nuclear-export-of-specific-trnas
#5
Christopher L Lord, Ophir Ospovat, Susan R Wente
Nuclear pore complexes (NPCs), which are composed of nucleoporins (Nups) and regulate transport between the nucleus and cytoplasm, significantly impact the replicative life span (RLS) of Saccharomyces cerevisiae We previously reported that deletion of the non-essential gene NUP100 increases RLS, although the molecular basis for this effect was unknown. In this study, we find that nuclear tRNA accumulation contributes to increased longevity in nup100Δ cells. Fluorescence in situ hybridization (FISH) experiments demonstrate several specific tRNAs accumulate in the nuclei of nup100Δ mutants...
December 8, 2016: RNA
https://www.readbyqxmd.com/read/27931373/sustainability
#6
Chein-Chi Chang, Kimberly DiGiovanni, Ying Mei, Li Wei
This review on Sustainability covers selected 2015 publications on the focus of Sustainability. It is divided into the following sections : Sustainable water and wastewater utilities Sustainable water resources management Stormwater and green infrastructure Sustainability in wastewater treatment Life cycle assessment (LCA) applications Sustainability and energy in wastewater industry, Sustainability and asset management.
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27931243/phase-1-2-study-of-pacritinib-a-next-generation-jak2-flt3-inhibitor-in-myelofibrosis-or-other-myeloid-malignancies
#7
Srdan Verstovsek, Olatoyosi Odenike, Jack W Singer, Tanya Granston, Suliman Al-Fayoumi, H Joachim Deeg
BACKGROUND: Pacritinib (SB1518) is a highly selective kinase inhibitor with specificity for JAK2, FLT3, IRAK1, and CFS1R. This multicenter phase 1/2 study evaluated the maximum tolerated dose (MTD), safety, and clinical activity of pacritinib in patients with myelofibrosis (MF) and other advanced myeloid malignancies. METHODS: In the phase 1 dose-escalation part of the study, 43 adults with advanced myeloid malignancies received pacritinib 100 to 600 mg once daily (QD)...
December 8, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27930682/ecoalim-a-dataset-of-environmental-impacts-of-feed-ingredients-used-in-french-animal-production
#8
Aurélie Wilfart, Sandrine Espagnol, Sylvie Dauguet, Aurélie Tailleur, Armelle Gac, Florence Garcia-Launay
Feeds contribute highly to environmental impacts of livestock products. Therefore, formulating low-impact feeds requires data on environmental impacts of feed ingredients with consistent perimeters and methodology for life cycle assessment (LCA). We created the ECOALIM dataset of life cycle inventories (LCIs) and associated impacts of feed ingredients used in animal production in France. It provides several perimeters for LCIs (field gate, storage agency gate, plant gate and harbour gate) with homogeneously collected data from French R&D institutes covering the 2005-2012 period...
2016: PloS One
https://www.readbyqxmd.com/read/27928760/cost-effectiveness-analysis-of-prophylaxis-treatment-strategies-to-reduce-the-incidence-of-febrile-neutropenia-in-patients-with-early-stage-breast-cancer-or-non-hodgkin-lymphoma
#9
Kelly Fust, Xiaoyan Li, Michael Maschio, Guillermo Villa, Anju Parthan, Richard Barron, Milton C Weinstein, Luc Somers, Caroline Hoefkens, Gary H Lyman
OBJECTIVE: The objective of this study was to evaluate the cost effectiveness of no prophylaxis, primary prophylaxis (PP), or secondary prophylaxis (SP) with granulocyte colony-stimulating factors (G-CSFs), i.e., pegfilgrastim, lipegfilgrastim, filgrastim (6- and 11-day), or lenograstim (6- and 11-day), to reduce the incidence of febrile neutropenia (FN) in patients with stage II breast cancer receiving TC (docetaxel, cyclophosphamide) and in patients with non-Hodgkin lymphoma (NHL) receiving R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) over a lifetime horizon from a Belgian payer perspective...
December 7, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27928734/the-effects-of-college-on-weight-examining-the-freshman-15-myth-and-other-effects-of-college-over-the-life-cycle
#10
Charles L Baum
This study examines the effects of college on weight over much of the life cycle. I compare weights for college students with their weights before and after college and with the weights of noncollege peers using data from the National Longitudinal Survey of Youth (NLSY). I also examine the longer-term effects of college measured almost three decades later. I find that college freshmen gain substantially less than the 15 pounds rumored to be typical for freshmen. Using difference models, individual-specific fixed-effects models, and instrumental variables models to control for various sources of potential bias, I find that freshman year college attendance is estimated to cause only about a one-pound increase...
December 7, 2016: Demography
https://www.readbyqxmd.com/read/27928726/evaluating-the-safety-profile-of-non-active-implantable-medical-devices-compared-with-medicines
#11
REVIEW
Josep Pane, Preciosa M Coloma, Katia M C Verhamme, Miriam C J M Sturkenboom, Irene Rebollo
Recent safety issues involving non-active implantable medical devices (NAIMDs) have highlighted the need for better pre-market and post-market evaluation. Some stakeholders have argued that certain features of medicine safety evaluation should also be applied to medical devices. Our objectives were to compare the current processes and methodologies for the assessment of NAIMD safety profiles with those for medicines, identify potential gaps, and make recommendations for the adoption of new methodologies for the ongoing benefit-risk monitoring of these devices throughout their entire life cycle...
December 7, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27928476/incidence-and-risk-factors-of-oral-mucositis-in-patients-with-breast-cancer-who-receiving-chemotherapy-in-al-bashir-hospital
#12
Ahmed A Al Ibraheemi, Shaimaa Shamoun
Background: Oral Mucositis (OM) remains the most common side effect of chemotherapy affects negatively on patients' quality of life. Subjects and Methods: Convenience samples of patients who received chemotherapy were followed from first or second cycle of chemotherapy until OM occurrence. We reviewed 75 female patients with breast cancer who received chemotherapy with mean age (47.2 SD ± 8.62861). We used WHO scale to assess the severity of OM. Demographic and other variables (age, number of cycle before appearance of signs of OM, WBC count, neutropenia count, creatinine and BMI) were filled in questionnaire...
October 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27928061/life-cycle-assessment-of-municipal-solid-waste-management-scenarios-on-the-small-island-of-mauritius
#13
Avinash Rajcoomar, Toolseeram Ramjeawon
The aim of this study was to use the life cycle assessment tool to assess, from an environmental point of view, the different possible municipal solid waste (MSW) management scenarios for the island of Mauritius. The scenarios include landfilling with energy recovery (S1), incineration with energy recovery (S2), composting, incineration and landfilling (S3) and finally composting, recycling, incineration and landfilling (S4). The MSW generated in 2010 was selected as the functional unit. Foreground data were collected through surveys and literature...
December 6, 2016: Waste Management & Research
https://www.readbyqxmd.com/read/27928018/expression-of-the-antisense-to-latency-transcript-long-noncoding-rna-in-kaposi-s-sarcoma-associated-herpesvirus
#14
Jason M Schifano, Kathleen Corcoran, Hemant Kelkar, Dirk P Dittmer
: The regulation of latency is central to herpesvirus biology. Recent transcriptome-wide surveys have uncovered evidence for promiscuous transcription across the entirety of the Kaposi sarcoma-associated herpesvirus genome and postulated the existence of multiple viral long noncoding RNAs (lncRNAs). NextGen sequencing studies are highly dependent on the specific experimental approach and particular algorithms of analysis, and therefore benefit from independent confirmation of the results...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27928011/high-prevalence-of-infectious-adeno-associated-virus-aav-in-human-peripheral-blood-mononuclear-cells-indicative-of-t-lymphocytes-as-sites-of-aav-persistence
#15
Daniela Hüser, Dina Khalid, Timo Lutter, Eva-Maria Hammer, Stefan Weger, Melanie Heßler, Ulrich Kalus, Yvonne Tauchmann, Karin Hensel-Wiegel, Dirk Lassner, Regine Heilbronn
: Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from man or non-human primates have so far not been proven as causes of human disease. In view of the increasing success of AAV-derived vectors in human gene therapy, the definition of the in vivo sites of wild-type AAV persistence and clinical consequences of its reactivation are becoming increasingly urgent.Here, we identified the presumed cell-type for AAV persistence in the human host, by highly sensitive AAV PCRs developed for the full spectrum of human AAV serotypes...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27928005/amino-acid-mutations-in-the-ns4a-region-of-hepatitis-c-virus-contribute-to-viral-replication-and-infectious-virus-production
#16
Asako Murayama, Nao Sugiyama, Ryosuke Suzuki, Masaki Moriyama, Noriko Nakamura, Hidenori Mochizuki, Takaji Wakita, Takanobu Kato
: Hepatitis C Virus (HCV) strain JFH-1, which belongs to genotype 2a, replicates autonomously in cultured cells, whereas another genotype 2a strain, J6CF, does not. Previously, we found that replacing the NS3 helicase and NS5B-to-3' X regions of J6CF with those of JFH-1 confers J6CF replication competence. In this study, we aimed to identify the minimum modifications to establish replication-competent J6CF within these genomic regions. We previously identified 4 mutations in the NS5B-to-3' X region that confer J6CF replication competence instead of replacing of this region...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27927842/parental-contributions-to-early-embryo-development-influences-of-urinary-phthalate-and-phthalate-alternatives-among-couples-undergoing-ivf-treatment
#17
Haotian Wu, Lisa Ashcraft, Brian W Whitcomb, Tayyab Rahil, Ellen Tougias, Cynthia K Sites, J Richard Pilsner
STUDY QUESTION: Are preconception urinary concentrations of phthalates and phthalate alternatives associated with diminished early stage embryo quality in couples undergoing IVF? SUMMARY ANSWER: Male, but not female, urinary concentrations of select metabolites of phthalates and phthalate alternatives are associated with diminished blastocyst quality. WHAT IS KNOWN ALREADY: Although phthalates are endocrine disrupting compounds associated with adverse reproductive health, they are in widespread use across the world...
December 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27927683/pharmacokinetics-and-pharmacodynamics-of-inorganic-nitrate-in-heart-failure-with-preserved-ejection-fraction
#18
Payman Zamani, Victor X Tan, Haideliza Soto-Calderon, Melissa Beraun, Jeffrey Brandimarto, Lien Trieu, Swapna Varakantam, Paschalis-Thomas Doulias, Raymond R Townsend, Jesse Chittams, Kenneth B Margulies, Thomas P Cappola, David C Poole, Harry Ischiropoulos, Julio A Chirinos
RATIONALE: Nitrate-rich beetroot juice has been shown to improve exercise capacity in Heart Failure with Preserved Ejection Fraction (HFpEF), but studies using pharmacologic preparations of inorganic nitrate are lacking. OBJECTIVE: To determine: (1) the dose-response effect of potassium nitrate (KNO3) on exercise capacity; (2) the population-specific pharmacokinetic and safety profile of KNO3 in HFpEF. METHODS AND RESULTS: We randomized 12 subjects with HFpEF to oral KNO3 (n=9) or potassium chloride (KCl, n=3)...
December 7, 2016: Circulation Research
https://www.readbyqxmd.com/read/27927250/experiences-of-caregivers-of-children-with-inherited-metabolic-diseases-a-qualitative-study
#19
Shabnaz Siddiq, Brenda J Wilson, Ian D Graham, Monica Lamoureux, Sara D Khangura, Kylie Tingley, Laure Tessier, Pranesh Chakraborty, Doug Coyle, Sarah Dyack, Jane Gillis, Cheryl Greenberg, Robin Z Hayeems, Shailly Jain-Ghai, Jonathan B Kronick, Anne-Marie Laberge, Julian Little, John J Mitchell, Chitra Prasad, Komudi Siriwardena, Rebecca Sparkes, Kathy N Speechley, Sylvia Stockler, Yannis Trakadis, Sarah Wafa, Jagdeep Walia, Kumanan Wilson, Nataliya Yuskiv, Beth K Potter
BACKGROUND: We sought to understand the experiences of parents/caregivers of children with inherited metabolic diseases (IMD) in order to inform strategies for supporting patients and their families. We investigated their experiences regarding the management of disease, its impact on child and family life, and interactions with the health care system. METHODS: From four Canadian centres, we conducted semi-structured telephone interviews with parents/caregivers of children with an IMD who were born between 2006 and 2015 and who were participating in a larger cohort study...
December 7, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27924459/patient-reported-outcomes-and-quality-of-life-with-sunitinib-versus-placebo-for-pancreatic-neuroendocrine-tumors-results-from-an-international-phase-iii-trial
#20
Aaron Vinik, Andrew Bottomley, Beata Korytowsky, Yung-Jue Bang, Jean-Luc Raoul, Juan W Valle, Peter Metrakos, Dieter Hörsch, Rajiv Mundayat, Arlene Reisman, Zhixiao Wang, Richard C Chao, Eric Raymond
OBJECTIVE: The objective of this analysis was to compare patient-reported outcomes and health-related quality of life (HRQoL) in a pivotal phase III trial of sunitinib versus placebo in patients with progressive, well-differentiated pancreatic neuroendocrine tumors (NCT00428597). PATIENTS AND METHODS: Patients received sunitinib 37.5 mg (n = 86) or placebo (n = 85) on a continuous daily-dosing schedule until disease progression, unacceptable adverse events (AEs), or death...
December 6, 2016: Targeted Oncology
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