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https://www.readbyqxmd.com/read/28732033/spatial-and-simultaneous-representative-seroprevalence-of-anti-toxoplasma-gondii-antibodies-in-owners-and-their-domiciled-dogs-in-a-major-city-of-southern-brazil
#1
Aline do Nascimento Benitez, Felippe Danyel Cardoso Martins, Marcelle Mareze, Nelson Jessé Rodrigues Santos, Fernanda Pinto Ferreira, Camila Marinelli Martins, João Luis Garcia, Regina Mitsuka-Breganó, Roberta Lemos Freire, Alexander Welker Biondo, Italmar Teodorico Navarro
Toxoplasmosis, caused by Toxoplasma gondii, has traditionally been considered an important water and foodborne protozoonosis with important public health considerations. Although felids play a well-established role as definitive hosts, canine epidemiological involvement in the parasite's life cycle remains questionable and controversial. The increasing closeness of the human-dog bond, particularly seen in urban settings, has been recognized as a historically unprecedented worldwide movement. Sharing daily lives in the same households, dogs may be exposed to similar associated risks of T...
2017: PloS One
https://www.readbyqxmd.com/read/28731295/biogeochemistry-of-lead-its-release-to-the-environment-and-chemical-speciation
#2
Jay T Cullen, Jason McAlister
Lead (Pb) is a metal that is not essential for life processes and proves acutely toxic to most organisms. Compared to other metals Pb is rather immobile in the environment but still its biogeochemical cycling is greatly perturbed by human activities. In this review we present a summary of information describing the physical and chemical properties of Pb, its distribution in crustal materials, and the processes, both natural and anthropogenic, that contribute to the metal's mobilization in the biosphere. The relatively high volatility of Pb metal, low melting point, its large ionic radius, and its chemical speciation in aquatic systems contributes to its redistribution by anthropogenic and natural processes...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731120/na3v2-po4-3-coated-by-n-doped-carbon-from-ionic-liquid-as-cathode-materials-for-high-rate-and-long-life-na-ion-batteries
#3
Yu Yao, Yu Jiang, Hai Yang, Xizhen Sun, Yan Yu
A facile and simple hydrothermal assisted sol-gel route was developed to prepare nitrogen doped carbon coated Na3V2(PO4)3 nanocomposites (denoted as NVP@C-N) as cathodes for sodium ion batteries (NIBs). An ionic liquid (EMIm-dca) was used as the nitrogen doped carbon source. The optimized N-doped carbon coated Na3V2(PO4)3 (denoted as NVP@C-N150) displays a very thin and uniform N-doped carbon coating layer (thickness: ∼2 nm), showing an excellent sodium storage performance (85 mA h g(-1) at 20 C after 5000 cycles) and high rate capability (71 mA h g(-1) at 80 C)...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28730970/healthy-diet-and-reduction-of-chronic-disease-risks-of-night-shift-workers
#4
Giovanni M Ferri, Domenica Cavone, Graziana Intranuovo, Linda Macinagrossa
BACKGROUND: The large increase in epidemiological studies on night shift work is due to the important effects of night shift work on workers' health and psychophysical wellbeing. The short-term effects-insomnia, difficulties in managing work and private life, lower work performance, and more work and extra-work accidents-are easily studied. However, there are several long-term effects that are difficult to study because of the need for detailed exposure assessment and the long latency periods of these diseases...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28730878/investigational-drugs-in-development-for-hepatitis-d
#5
Mario Rizzetto
Treatment of chronic hepatitis D still relies on Interferon. To improve efficacy, new therapeutic strategies are in development which aim to deprive the Hepatitis D Virus (HDV) of functions of the Hepatitis B Virus and of the host required for its life-cycle. Areas covered: The therapeutic options are; 1) The inhibition of the farnesylation of the large HD-protein permissive of virion assembly with Lonafarnib, 2) The blocking of HBsAg entry into cells with Myrcludex B via the inhibition of the Sodium Taurocholate Cotransporting Receptor, to prevent the spreading of HDV to uninfected hepatocytes, 3) The reduction of subviral HBsAg particles by REP 2139, leading to diminished virion morphogenesis ...
July 21, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28730675/hierarchical-hybrids-integrated-by-dual-polypyrrole-based-porous-carbons-for-enhanced-capacitive-performance
#6
Zhiwei Li, Nannan Chen, Hongyu Mi, Junhong Ma, Yahong Xie, Jieshan Qiu
Architectural design of nitrogenous polymer-based carbons represents a facile and efficient strategy in performance improvement because of their morphological diversity, tailorability, and N-containing structure. In this research, polypyrrole-derived porous carbons (A-PCS and A-PCT) in zero- and one-dimensional (0D and 1D) forms are first integrated to nitrogen-doped hierarchically porous A-PCS/PCT hybrids through an easy multi-step method. This integration, along with chemical activation, prevents serious agglomeration of carbon particles or tubes and creates a through-connected porous network structure, leading to the improved textural properties (high surface area of 1684 m2 g-1, high pore volume of 1...
July 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28729852/towards-better-understanding-of-the-pathogenesis-of-neuronal-respiratory-network-in-sudden-perinatal-death
#7
REVIEW
Riffat Mehboob, Mahvish Kabir, Naseer Ahmed, Fridoon Jawad Ahmad
Sudden perinatal death that includes the victims of sudden infant death syndrome, sudden intrauterine death syndrome, and stillbirth are heartbreaking events in the life of parents. Most of the studies about sudden perinatal death were reported from Italy, highlighting two main etiological factors: prone sleeping position and smoking. Other probable contributory factors are prematurity, male gender, lack of breastfeeding, respiratory tract infections, use of pacifiers, infant botulism, extensive use of pesticides and insecticides, etc...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28729727/senescent-cells-an-emerging-target-for-diseases-of-ageing
#8
REVIEW
Bennett G Childs, Martina Gluscevic, Darren J Baker, Remi-Martin Laberge, Dan Marquess, Jamie Dananberg, Jan M van Deursen
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies...
July 21, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28729506/highly-elastic-binders-integrating-polyrotaxanes-for-silicon-microparticle-anodes-in-lithium-ion-batteries
#9
Sunghun Choi, Tae-Woo Kwon, Ali Coskun, Jang Wook Choi
Lithium-ion batteries with ever-increasing energy densities are needed for batteries for advanced devices and all-electric vehicles. Silicon has been highlighted as a promising anode material because of its superior specific capacity. During repeated charge-discharge cycles, silicon undergoes huge volume changes. This limits cycle life via particle pulverization and an unstable electrode-electrolyte interface, especially when the particle sizes are in the micrometer range. We show that the incorporation of 5 weight % polyrotaxane to conventional polyacrylic acid binder imparts extraordinary elasticity to the polymer network originating from the ring sliding motion of polyrotaxane...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28729386/dormancy-in-embryos-insight-from-hydrated-encysted-embryos-of-an-aquatic-invertebrate
#10
Tamar Ziv, Vered Chalifa-Caspi, Nadav Denekamp, Inbar Plaschkes, Sylwiya Sylwia Kierszniowska, Idit Blais, Arie Admon, Esther Lubzens
Numerous aquatic invertebrates remain dormant for decades in a hydrated state as encysted embryos. In search for functional pathways associated with this form of dormancy, we used label-free quantitative proteomics to compare the proteomes of hydrated encysted dormant embryos (resting eggs; RE) with non-dormant embryos (amictic eggs; AM) of the rotifer Brachionus plicatilis</p> <p>A total of 2,631 proteins were identified in rotifer eggs. About 62% proteins showed higher abundance in AM relative to RE (Fold Change>3; p=0...
July 20, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28729383/definitions-and-end-points-for-interventional-studies-for-arteriovenous-dialysis-access
#11
Gerald A Beathard, Charmaine E Lok, Marc H Glickman, Ahmed A Al-Jaishi, Donna Bednarski, David L Cull, Jeffery H Lawson, Timmy C Lee, Vandana D Niyyar, Donna Syracuse, Scott O Trerotola, Prabir Roy-Chaudhury, Surendra Shenoy, Margo Underwood, Haimanot Wasse, Karen Woo, Theodore H Yuo, Thomas S Huber
This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points which would be best suited to inform decisions in those situations in which supportive clinical data are required. The focus of a portion of the project is directed toward arteriovenous access. There is a potential for interventional studies to be directed toward any of the events that may be associated with an arteriovenous access' evolution throughout its life cycle, which has been divided into five distinct phases...
July 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28729070/abc-transporters-in-the-liver-fluke-opisthorchis-felineus
#12
Viatcheslav A Mordvinov, Nikita I Ershov, Darya S Pirozhkova, Yuri V Pakharukov, Maria Y Pakharukova
ATP-binding cassette transporters (ABC transporters) are essential components of normal cellular physiological machinery in all eukaryotic and prokaryotic species, including parasites. Some ABC transporters, e.g., P-glycoproteins, are involved in the efflux of toxins and xenobiotics from the cell. At present, nothing is known about ABC transporter genes in epidemiologically important liver flukes from the Opisthorchiidae family, including European liver fluke Opisthorchis felineus. Opisthorchiasis caused by O...
July 17, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28728995/a-mechanistic-model-quantifies-artemisinin-induced-parasite-growth-retardation-in-blood-stage-plasmodium-falciparum-infection
#13
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, David S Khoury, Deborah Cromer, Miles P Davenport, Leann Tilley, Julie A Simpson, James M McCaw
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives-the most effective and widely-used antimalarials that have helped reduce the burden of malaria by 60% in some areas over the past decade-have recently been found to induce growth retardation of blood-stage Plasmodium falciparum when applied at clinically relevant concentrations. To date, no model has been designed to quantify the growth retardation effect and to predict the influence of this property on in vivo parasite killing...
July 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28728830/the-echinococcoses-in-asia-the-present-situation
#14
REVIEW
Akira Ito, Christine M Budke
Human alveolar and cystic echinococcosis, caused by the accidental ingestion of eggs of the tapeworms Echinococcus multilocularis and Echinococcus granulosus sensu lato, respectively, are endemic in Asia. Various Echinococcus species are maintained in domesticated and/or wild mammals through predator-prey interactions. Molecular analysis is used to help differentiate infecting parasite species and genotypes, with the goal of better understanding parasite life cycles in order to aid in the planning and implementation of control programs...
July 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28728789/evaluation-of-the-environmental-sustainability-of-different-waste-to-energy-plant-configurations
#15
Lidia Lombardi, Ennio A Carnevale
Residual municipal solid waste (MSW) has an average lower heating value higher than 10GJ/Mg in the EU, and can be recovered in modern Waste-to-Energy (WtE) plants, producing combined heat and power (CHP) and reaching high levels of energy recovery. CHP is pinpointed as the best technique for energy recovery from waste. However, in some cases, heat recovery is not technically feasible - due to the absence of a thermal user (industrial plant or district heating) in the vicinity of the WtE plant - and power production remains the sole possibility...
July 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28726986/board-invited-review-quantifying-water-use-in-ruminant-production
#16
G Legesse, K H Ominski, K A Beauchemin, S Pfister, M Martel, E J McGeough, A Y Hoekstra, R Kroebel, M R C Cordeiro, T A McAllister
The depletion of water resources, in terms of both quantity and quality, has become a major concern both locally and globally. Ruminants, in particular, are under increased public scrutiny due to their relatively high water use per unit of meat or milk produced. Estimating the water footprint of livestock production is a relatively new field of research for which methods are still evolving. This review describes the approaches used to quantify water use in ruminant production systems as well as the methodological and conceptual issues associated with each approach...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726080/proteomic-approach-to-address-low-seed-germination-in-cyclobalnopsis-gilva
#17
REVIEW
Madiha Zaynab, Sonia Kanwal, Muhammad Furqan, Waqar Islam, Ali Noman, Ghulam Muhammad Ali, Nazia Rehman, Sara Zafar, Kalsoom Sughra, Muhammad Jahanzab
Seeds play essential roles in plant life cycle and germination is a complex process which is associated with different phases of water imbibition. Upon imbibition, seeds begin utilization of storage substances coupled with metabolic activity and biosynthesis of new proteins. Regeneration of organelles and emergence of radicals lead to the establishment of seedlings. All these activities are regulated in coordinated manners. Translation is the requirement of germination of seeds via involvements of several proteins like beta-amylase, starch phosphorylase...
July 19, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28726049/quarterly-repeat-cycles-of-onabotulinumtoxina-in-chronic-migraine-patients-the-benefits-of-the-prolonged-treatment-on-the-continuous-responders-and-quality-of-life-conversion-rate-in-a-real-life-setting
#18
Antonio Santoro, Andrea Fontana, Anna M Miscio, Michele M Zarrelli, Massimiliano Copetti, Maurizio A Leone
OnabotulinumtoxinA was approved for treatment of chronic migraine (CM) after publication of Phase 3 Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) trials. However, the PREEMPT trials lasted only up to 1 year. The main aim of our retrospective study was to evaluate whether a prolonged treatment of onabotulinumtoxinA (18 months, six quarterly cycles) will sustain or further improve the efficacy results and the quality of life achieved at 6 and 12 months. Patients were adults with CM with or without overuse of drugs, with at least six regularly repeat onabotulinumtoxinA treatments, administered according to the PREEMPT protocol...
July 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28725528/battery-supercapacitor-hybrid-devices-recent-progress-and-future-prospects
#19
REVIEW
Wenhua Zuo, Ruizhi Li, Cheng Zhou, Yuanyuan Li, Jianlong Xia, Jinping Liu
Design and fabrication of electrochemical energy storage systems with both high energy and power densities as well as long cycling life is of great importance. As one of these systems, Battery-supercapacitor hybrid device (BSH) is typically constructed with a high-capacity battery-type electrode and a high-rate capacitive electrode, which has attracted enormous attention due to its potential applications in future electric vehicles, smart electric grids, and even miniaturized electronic/optoelectronic devices, etc...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28725390/grazed-wet-meadows-are-sink-habitats-for-the-southern-dunlin-calidris-alpina-schinzii-due-to-nest-trampling-by-cattle
#20
Veli-Matti Pakanen, Sami Aikio, Aappo Luukkonen, Kari Koivula
The effect of habitat management is commonly evaluated by measuring population growth, which does not distinguish changes in reproductive success from changes in survival or the effects of immigration or emigration. Management has rarely been evaluated considering complete life cycle of the target organisms, including also possible negative impacts from management. We evaluated the effectiveness of cattle grazing in the restoration of coastal meadows as a breeding habitat for small and medium-sized ground-nesting birds by examining the size and demography of a southern dunlin (Calidris alpina schinzii) breeding population...
October 2016: Ecology and Evolution
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