Saptarshi Chakraborty, Brett L Ecker, Ken Seier, Victoria G Aveson, Vinod P Balachandran, Jeffrey A Drebin, Michael I D'Angelica, T Peter Kingham, Carlie S Sigel, Kevin C Soares, Efsevia Vakiani, Alice C Wei, Rohit Chandwani, Mithat Gonen, Ronglai Shen, William R Jarnagin
PURPOSE: The clinical behavior of ampullary adenocarcinoma varies widely. Targeted tumor sequencing may better define biologically distinct subtypes to improve diagnosis and management. EXPERIMENTAL DESIGN: The hidden-genome algorithm, a multilevel meta-feature regression model, was trained on a prospectively sequenced cohort of 3,411 patients (1,001 pancreatic adenocarcinoma, 165 distal bile-duct adenocarcinoma, 2,245 colorectal adenocarcinoma) and subsequently applied to targeted panel DNA-sequencing data from ampullary adenocarcinomas...
November 1, 2021: Clinical Cancer Research