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Cardiovascular perfusion

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https://www.readbyqxmd.com/read/29447429/arterial-stiffness-and-subendocardial-viability-ratio-in-patients-with-peripheral-arterial-disease
#1
Giovanni Scandale, Gabriel Dimitrov, Martino Recchia, Gianni Carzaniga, Marzio Minola, Edoardo Perilli, Maria Carotta, Mariella Catalano
Arterial stiffening is a hallmark of the aging process and atherosclerosis, including peripheral arterial disease (PAD). We investigated the associations between carotid-femoral pulse wave velocity (c-fPWV), augmentation index corrected for heart rate (Aix@HR75), ankle brachial index (ABI), and subendocardial viability ratio (SEVR), an indicator of cardiac perfusion. The c-fPWV, Aix@HR75, and SEVR was estimated using applanation tonometry. The ankle systolic pressure measurements for the calculation of the ABI were obtained using an 8-mHz Doppler probe...
February 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29447342/diagnosing-coronary-artery-disease-after-a-positive-coronary-computed-tomography-angiography-the-dan-nicad-open-label-parallel-head-to-head-randomized-controlled-diagnostic-accuracy-trial-of-cardiovascular-magnetic-resonance-and-myocardial-perfusion-scintigraphy
#2
L Nissen, S Winther, J Westra, J A Ejlersen, C Isaksen, A Rossi, N R Holm, G Urbonaviciene, L C Gormsen, L H Madsen, E H Christiansen, M Maeng, L L Knudsen, L Frost, L Brix, H E Bøtker, S E Petersen, M Bøttcher
Aims: Perfusion scans after coronary computed tomography angiography (CCTA) in patients with suspected coronary artery disease (CAD) may reduce unnecessary invasive coronary angiographies (ICAs). However, the diagnostic accuracy of perfusion scans after primary CCTA is unknown. The aim of this study was to determine the diagnostic accuracy of cardiac magnetic resonance (CMR) and myocardial perfusion scintigraphy (MPS) against ICA with fractional flow reserve (FFR) in patients suspected of CAD by CCTA...
February 13, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29441909/the-effect-of-continuous-perfusion-of-esmolol-on-cardiovascular-risk-in-elderly-patients-undergoing-noncardiac-surgery
#3
X K Zhang, Q Hu, Q H Chen, W X Wang
We evaluated the effect of continuous perfusion of esmolol on cardiovascular risk during curative laparoscopic surgery for gastrointestinal cancer in elderly patients. Sixty patients with gastrointestinal cancer, aged from 60 to 80 years, were divided into an esmolol group (ES, n = 30) and a control group (NS, n = 30). ES patients were treated with esmolol at a dose of 0.3 mg/kg 3 min before tracheal intubation, and received continuous perfusion of esmolol at a dose of 50 μg/kg/min during operation. In NS, esmolol was replaced by saline...
August 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29438436/assessment-of-coronary-vascular-function-with-cardiac-pet-in-relation-to-serum-uric-acid
#4
Seoyoung C Kim, Nishant R Shah, James R Rogers, Courtney F Bibbo, Marcelo F Di Carli, Daniel H Solomon
BACKGROUND: Elevated serum uric acid (SUA) levels have been independently associated with cardiovascular disease. Stress myocardial perfusion positron emission tomography (PET) allows for measurement of absolute myocardial blood flow (MBF) and quantification of global left ventricular coronary flow reserve (CFR). A CFR <2.0 is considered impaired coronary vascular function, and it is associated with increased cardiovascular risk. We evaluated the relationship between SUA and PET-measured markers of coronary vascular function...
2018: PloS One
https://www.readbyqxmd.com/read/29433344/association-of-cardiovascular-risk-factors-on-myocardial-perfusion-and-fibrosis-in-asymptomatic-individuals-cardiac-magnetic-resonance-study
#5
Min Jae Cha, Sung Mok Kim, Hyun Su Kim, Yiseul Kim, Yeon Hyeon Choe
Background Myocardial perfusion reserve index (MPRI) and extracellular volume fraction (ECV) on cardiac magnetic resonance (CMR) are known to quantify coronary microvascular dysfunction and myocardial fibrosis, respectively. Purpose To demonstrate that cardiovascular risk factors such as hypertension, diabetes, hyperlipidemia, and smoking are correlated with MPRI and ECV on CMR in asymptomatic individuals. Material and Methods Between October 2013 and July 2014, 196 individuals underwent CMR. After excluding those with chest pain, arrhythmia, and obstructive coronary artery disease, participants were divided into five groups: those without risk factor (n = 26) and those with one (n = 43), two (n = 35), three (n = 24), or four (n = 6) risk factors...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29432130/combined-assessment-of-stress-myocardial-perfusion-cardiovascular-magnetic-resonance-and-flow-measurement-in-the-coronary-sinus-improves-prediction-of-functionally-significant-coronary-stenosis-determined-by-fractional-flow-reserve-in-multivessel-disease
#6
Shiro Nakamori, Hajime Sakuma, Kaoru Dohi, Masaki Ishida, Takashi Tanigawa, Akimasa Yamada, Shinichi Takase, Hiroshi Nakajima, Toshiki Sawai, Jun Masuda, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Eitaro Fujii, Norikazu Yamada, Masaaki Ito
BACKGROUND: Recent studies using stress-rest perfusion cardiovascular magnetic resonance (CMR) demonstrated a close correlation between myocardial ischemia and reduced fractional flow reserve (FFR). However, its diagnostic concordance may be reduced in patients with multivessel disease. We sought to evaluate the concordance of adenosine stress-rest perfusion CMR for predicting reduced FFR, and to determine the additive value of measuring global coronary flow reserve (CFR) in the coronary sinus in multivessel disease...
January 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29424731/efficacy-of-cardiac-shock-wave-therapy-in-patients-with-stable-angina-the-design-of-randomized-triple-blind-sham-procedure-controlled-study
#7
Evgeny Shkolnik, Greta Burneikaite, Jelena Celutkiene, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Aleksandras Laucevicius, Yury Vasyuk
OBJECTIVE: Despite revascularization and optimal medical treatment (OMT), patients with angina often have a reduced quality of life due to inadequate relief from symptoms. Recent studies have shown that the application of shock waves may reduce angina symptoms and improve quality of life, exercise capacity, and myocardial perfusion due to the stimulation of angiogenesis. However, there is limited evidence due to small, single-arm, single-center studies of low to moderate quality. The purpose of this study is to evaluate the impact of cardiac shock wave therapy (CSWT) on exercise tolerance and angina symptoms in patients with coronary artery disease and objective evidence of myocardial ischemia who cannot undergo traditional revascularization and experience angina despite OMT in comparison to sham procedure...
February 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29419573/important-role-of-endothelial-caveolin-1-in-the-protective-role-of-endothelium-dependent-hyperpolarization-against-nitric-oxide-mediated-nitrative-stress-in-microcirculation-in-mice
#8
Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, Hiroaki Shimokawa
AIMS: Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size, as a NO generating system in conduit arteries and an EDH-mediated system in resistance arteries, for which caveolin-1 (Cav-1) is involved. However, the physiological role of endothelial Cav-1 in microvessels remains to be elucidated. METHODS AND RESULTS: We newly generated endothelium-specific Cav-1-knockout (eCav-1-KO) mice...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29416252/perioperative-use-of-transthoracic-echocardiography-in-a-patient-with-congenitally-corrected-transposition-of-great-arteries-atrial-septal-defect-and-severe-pulmonary-stenosis-for-lower-segment-cesarean-section
#9
Vikas Saini, Tanvir Samra, Gurpreet Kaur
A 25-year-old female with congenitally corrected transposition of great arteries (CCTGAs), atrial septal defect, and severe pulmonary stenosis underwent lower segment cesarean section at 34 weeks of gestation using combined spinal epidural anesthesia (CSEA). We used transthoracic echocardiography (TTE) for intraoperative monitoring of the cardiovascular system because these patients are reported to have a high prevalence of myocardial perfusion defects, regional wall motion abnormalities, and impaired ventricular contractility...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29413668/qtc-prolongation-increased-nt-probnp-and-pre-clinical-myocardial-wall-remodeling-in-excessive-alcohol-consumers-the-sabpa-study
#10
Annemarie Wentzel, Leoné Malan, Jacobus D Scheepers, Nicolaas T Malan
Alcohol contributes greatly to vascular and structural modifications. Due to differences in the metabolism and tolerance of alcohol between ethnic groups, the manner of these modifications may differ. We investigated the association between alcohol consumption - measured via ethnic-specific gamma glutamyl transferase (γ-GT) cut-points - and markers of cardiac perfusion, electrical activity, and pre-clinical structural alterations. A South African target population study was performed in a bi-ethnic cohort (n = 405)...
September 14, 2017: Alcohol
https://www.readbyqxmd.com/read/29408989/modified-predictive-score-based-on-frailty-for-mid-term-outcomes-in-open-total-aortic-arch-surgery
#11
Arudo Hiraoka, Kazuya Saito, Genta Chikazawa, Toshinori Totsugawa, Kentaro Tamura, Atsuhisa Ishida, Taichi Sakaguchi, Hidenori Yoshitaka
OBJECTIVES: The aim of this study was to seek a new predictor of mid-term survival of surgical total aortic arch replacement (SAR) by evaluating indices relevant to frailty. METHODS: Between October 2012 and March 2017, 113 consecutive patients underwent elective surgical total aortic arch replacement with antegrade cerebral perfusion under circulatory arrest at a single cardiovascular institute. In addition to common parameters, Katz index of activities of daily living, nutritional status, skeletal muscle mass volume, swallowing and motor functions were used to evaluate patients' frailty...
February 2, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29399757/the-clinical-usefulness-of-epicardial-adipose-tissue-in-patients-with-high-intermediate-pre-test-probability-for-coronary-artery-disease
#12
Regayip Zehir, Ahmet Güner, Mert Ilker Hayiroglu, Tugba Kemaloğlu Oz, Altug Osken, Huseyin Aksu, Sennur Unal Dayi, Gultekin Faik Hobikoğlu
BACKGROUND: Epicardial adipose tissue [EAT] is thought to be associated with extension and severity of coronary artery disease [CAD] and echocardiographic measurement of EAT thickness has been considered to be a possible cardiovascular risk indicator. ESC Task Force recommends further non-invasive testing in patients with an intermediate pre-test probability [PTP] for the diagnosis of CAD. AIM: The purpose of this study was to evaluate the clinical usefulness of performing EAT measurements in patients with a high-intermediate PTP...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29389729/a-narrative-review-of-cardiovascular-abnormalities-after-spontaneous-intracerebral-hemorrhage
#13
Abhijit Lele, Viharika Lakireddy, Sergii Gorbachov, Nophanan Chaikittisilpa, Vijay Krishnamoorthy, Monica S Vavilala
BACKGROUND: The recommended cardiac workup of patients with spontaneous intracerebral hemorrhage (ICH) includes an electrocardiogram (ECG) and cardiac troponin. However, abnormalities in other cardiovascular domains may occur. We reviewed the literature to examine the spectrum of observed cardiovascular abnormalities in patients with ICH. METHODS: A narrative review of cardiovascular abnormalities in ECG, cardiac biomarkers, echocardiogram, and hemodynamic domains was conducted on patients with ICH...
January 31, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29386056/simple-motion-correction-strategy-reduces-respiratory-induced-motion-artifacts-for-k-t-accelerated-and-compressed-sensing-cardiovascular-magnetic-resonance-perfusion-imaging
#14
Ruixi Zhou, Wei Huang, Yang Yang, Xiao Chen, Daniel S Weller, Christopher M Kramer, Sebastian Kozerke, Michael Salerno
BACKGROUND: Cardiovascular magnetic resonance (CMR) stress perfusion imaging provides important diagnostic and prognostic information in coronary artery disease (CAD). Current clinical sequences have limited temporal and/or spatial resolution, and incomplete heart coverage. Techniques such as k-t principal component analysis (PCA) or k-t sparcity and low rank structure (SLR), which rely on the high degree of spatiotemporal correlation in first-pass perfusion data, can significantly accelerate image acquisition mitigating these problems...
February 1, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29384857/heart-rate-variability-in-normal-tension-glaucoma-a-case-control-study
#15
Natalia Ivanovna Kurysheva, Vitaliy Nikiforovich Shlapak, Tamara Yakovlevna Ryabova
Primary vascular dysregulation (PVD) is believed to be a main cause of local vasospasm and impaired autoregulation as a possible contributing factor in the pathogenesis of normal tension glaucoma (NTG). Subjects with PVD respond stronger to psychological stress. Autonomic dysfunction is another reason of instable ocular blood flow and may be studied by means of assessment of heart rate variability (HRV) especially during a hand-cold provocation test (CPT).To compare the shift of HRV parameters in NTG and healthy subjects after a cold provocation test and to assess the relation between structural damage, circulatory parameters and autonomic dysfunction in NTG...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382969/comparison-of-the-oral-and-rectal-mucosal-and-colonic-serosal-microcirculations-of-healthy-anesthetized-horses
#16
Philip J Kieffer, Jarred M Williams, Molly K Shepard, Steeve Giguère, Kira L Epstein
The objectives of the study were to: i) determine baseline microvascular perfusion indices (MPI) and assess their repeatability in healthy horses under general anesthesia, and ii) compare the MPIs of 3 microvascular beds (oral mucosa, colonic serosa, and rectal mucosa). Healthy adult horses were anesthetized and sidestream dark field microscopy was used to collect video loops of the oral mucosa, rectal mucosa, and colonic serosa under normotensive conditions without cardiovascular support drugs; videos were later analyzed to produce MPIs...
January 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29382844/deciphering-microvascular-changes-after-myocardial-infarction-through-3d-fully-automated-image-analysis
#17
Polyxeni Gkontra, Kerri-Ann Norton, Magdalena M Żak, Cristina Clemente, Jaume Agüero, Borja Ibáñez, Andrés Santos, Aleksander S Popel, Alicia G Arroyo
The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding the impact of cardiovascular diseases in tissue perfusion and in developing efficient angiotherapies. Using confocal microscopy and thick tissue sections, we developed a 3D fully automated pipeline that allows to precisely reconstruct the microvasculature and to extract parameters that quantify all its major features, its relation to smooth muscle actin positive cells and capillary diffusion regions...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382301/decreased-global-myocardial-perfusion-at-adenosine-stress-as-a-potential-new-biomarker-for-microvascular-disease-in-systemic-sclerosis-a-magnetic-resonance-study
#18
Tom Gyllenhammar, Mikael Kanski, Henrik Engblom, Dirk M Wuttge, Marcus Carlsson, Roger Hesselstrand, Håkan Arheden
BACKGROUND: Patients with systemic sclerosis (SSc) have high cardiovascular mortality even though there is no or little increase in prevalence of epicardial coronary stenosis. First-pass perfusion on cardiovascular magnetic resonance (CMR) have detected perfusion defects indicative of microvascular disease, but the quantitative extent of hypoperfusion is not known. Therefore, we aimed to determine if patients with SSc have lower global myocardial perfusion (MP) at rest or during adenosine stress, compared to healthy controls, quantified with CMR...
January 30, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29375141/reperfusion-after-pulmonary-embolism-long-term-follow-up-risk-factors-clinical-impact
#19
Jan Mrozek, Jana Petrova, Jana Vaclavkova, Vladimir Janovsky, Lubos Kraus, Pavel Jansa
BACKGROUND AND AIM: Thromboembolic disease is the third most common cardiovascular disorder and deep vein thrombosis carries the risk of pulmonary embolism (PE). Questions related to reperfusion after PE remain, especially risk factors. Incomplete reperfusion after PE is closely related to the development of chronic thromboembolic pulmonary hypertension. The aim of this study was to determine the relation between reperfusion after PE in the long term over a period of 24 months, laboratory results and clinical risk factors found during the initial PE event...
January 24, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29369521/brief-challenges-on-medicinal-plants-an-eye-opening-look-at-ageing-related-disorders
#20
Geir Bjørklund, Maryam Dadar, Natália Martins, Salvatore Chirumbolo, Bey Hing Goh, Kateryna Smetanina, Roman Lysiuk
Several studies have reported that nature-derived antioxidants may prevent free radicals over-production and therefore control the onset and prevent the exacerbation of different kinds of diseases caused by oxidative stress and redox-derived stressors, including ageing, fundamentally by suppressing the oxidative byproducts-mediated degradation. Naturally derived antioxidants exert their anti-ageing action via a panoply of signalling systems, many of which engaging reactive oxygen (ROS) and nitrogen (RNS) species scavenging, with the Nrf2/Keap1-ARE system and improving the many survival genes and functions (such as the pathway mTOR/Foxo/SIRT1) able to slow cellular senescence...
January 25, 2018: Basic & Clinical Pharmacology & Toxicology
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