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https://www.readbyqxmd.com/read/27559846/depression-moderates-the-relationship-between-pain-and-the-nonmedical-use-of-opioid-medication-among-adult-outpatients
#1
Michael J Mason, Gregory Golladay, William Jiranek, Brian Cameron, Joel J Silverman, Nikola M Zaharakis, Paul Plonski
BACKGROUND: The nonmedical use of prescription medication among US adults is a growing public health problem. Healthcare providers should proactively address this problem in outpatient encounters. OBJECTIVE: We sought to understand the interactive effects among prescription drugs, pain, and psychiatric symptoms among adult outpatients to build an empirical foundation for comprehensive screening. METHODS: We screened 625 adult neurosurgery and orthopedic patients at a suburban satellite clinic of an urban academic medical center...
September 7, 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27148886/neonatal-encephalopathy-in-new-zealand-demographics-and-clinical-outcome
#2
M Battin, L Sadler, V Masson, C Farquhar
AIM: To establish the incidence of moderate to severe neonatal encephalopathy (NE) in term infants from New Zealand and to document demographic characteristics and neonatal outcomes. METHODS: Cases were reported monthly via the New Zealand Paediatric Surveillance Unit (NZPSU). Data were collected from paediatricians for neonatal items and lead maternity carers for pregnancy and birth details. Term neonatal deaths in the Perinatal and Maternal Mortality Review Committee dataset that were because of hypoxia and/or neonatal deaths from hypoxic ischaemic encephalopathy were added to the cases identified via the NZPSU, if they had not previously been ascertained...
June 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/26975506/selected-pet-radioligands-for-ion-channel-linked-neuroreceptor-imaging-focus-on-gaba-nmda-and-nach-receptors
#3
Alina Kassenbrock, Neil Vasdev, Steven H Liang
Positron emission tomography (PET) neuroimaging of ion channel linked receptors is a developing area of preclinical and clinical research. The present review focuses on recent advances with radiochemistry, preclinical and clinical PET imaging studies of three receptors that are actively pursued in neuropsychiatric drug discovery: namely the γ-aminobutyric acid-benzodiazapine (GABA) receptor, nicotinic acetylcholine receptor (nAChR), and N-methyl-D-aspartate (NMDA) receptor. Recent efforts to develop new PET radioligands for these targets with improved brain uptake, selectivity, stability and pharmacokinetics are highlighted...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/23753931/serotonin-syndrome-associated-with-clozapine-withdrawal
#4
Elizabeth Stevenson, Frank Schembri, Deborah M Green, Joseph D Burns
IMPORTANCE: We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has been rarely reported. OBSERVATIONS: This is a case report of a 47-year-old woman admitted to an academic medical center intensive care unit with coma, hypersalivation, hyperreflexia, and stimulus-induced clonus. The patient received a diagnosis of serotonin syndrome attributed to abrupt clozapine withdrawal with concomitant use of citalopram...
August 2013: JAMA Neurology
https://www.readbyqxmd.com/read/21932753/prevalence-of-drug-use-in-pregnant-west-virginia-patients
#5
Michael L Stitely, Byron Calhoun, Stefan Maxwell, Robert Nerhood, David Chaffin
INTRODUCTION: Substance abuse in pregnancy is of serious concern to society as well as health care providers caring for pregnant women and their infants. Various studies have suggested a prevalence of 10 -20%. This study used anonymous sampling of umbilical cord tissue to estimate the prevalence of substance abuse in West Virginia. METHODS: For the period of August 2009, as many umbilical cord samples as possible were collected at 8 regionally diverse hospitals in West Virginia...
2010: West Virginia Medical Journal
https://www.readbyqxmd.com/read/21184391/-delirium-induced-by-drug-treatment
#6
Christine Back, Markus Wittmann, Ekkehard Haen
Delirium may be induced by a variety of reasons, among them drugs and in particular the combination of drugs. In elderly people a delirium is often misinterpreted as dementia. Anticholinergic activity is the mode of action by which drugs cause delirium. Antipsychotic drugs, antidepressants, antihistamines, and of course anticholinergic drugs themselves are the major anticholinergic classes of drugs. In addition some opioids have anticholinergic effects. Other drugs may induce delirium by dehydration (loop diuretics like furosemide) or sedation (benzodiazapines like lorazepam)...
January 2011: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/20850231/assessing-sleep-in-opioid-dependence-a-comparison-of-subjective-ratings-sleep-diaries-and-home-polysomnography-in-methadone-maintenance-patients
#7
COMPARATIVE STUDY
Katherine M Sharkey, Megan E Kurth, Bradley J Anderson, Richard P Corso, Richard P Millman, Michael D Stein
OBJECTIVES: Comparisons of subjective and objective sleep measures have shown discrepancies between reported sleep and polysomnography (PSG) in non-drug dependent individuals with and without insomnia. Sleep may affect behavioral and physiologic aspects of drug abuse and dependence; patients in methadone maintenance therapy (MMT) for opioid dependence frequently report sleep problems. Whether subjective sleep reflects objective sleep in MMT patients is unknown. We undertook these analyses to establish the correlations among subjective and objective sleep measures in MMT patients...
January 15, 2011: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/19821364/benzodiazepines-for-delirium
#8
REVIEW
Edmund Lonergan, Jay Luxenberg, Almudena Areosa Sastre
BACKGROUND: Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium. OBJECTIVES: To determine the effectiveness and incidence of adverse effects of benzodiazapines in the treatment of non-alcohol withdrawal related delirium. SEARCH STRATEGY: The trials were identified from a search of the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group on 26 February 2008 using the search terms: (deliri* or confusion) and (benzo* or lorazepam," or "alprazolam" or "ativan" or diazepam or valium or chlordiazepam)...
2009: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/19643610/design-and-discovery-of-1-3-benzodiazepines-as-novel-dopamine-antagonists
#9
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Brian McKittrick, William Greenlee, Michael Czarniecki, Ahmad Fawzi, Hongtao Zhang, Jean E Lachowicz
A series of novel 1,3-benzodiazapine based D1 antagonists was designed according to the understanding of pharmacophore models derived from SCH 23390 (1b), a potent and selective D1 antagonist. The new design features an achiral cyclic-amidine that maintains desired basicity. Solid phase synthesis was developed for SAR development of the novel dopamine antagonists.
September 1, 2009: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/19160280/benzodiazepines-for-delirium
#10
REVIEW
Edmund Lonergan, Jay Luxenberg, Almudena Areosa Sastre, Torgeir Bruun Wyller
BACKGROUND: Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium. OBJECTIVES: To determine the effectiveness and incidence of adverse effects of benzodiazapines in the treatment of non-alcohol withdrawal related delirium. SEARCH STRATEGY: The trials were identified from a search of the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group on 26 February 2008 using the search terms: (deliri* or confusion) and (benzo* or lorazepam," or "alprazolam" or "ativan" or diazepam or valium or chlordiazepam)...
2009: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/18537477/gender-and-age-differences-in-medications-dispensed-from-a-national-chain-drugstore
#11
Marietta Anthony, Kwan Y Lee, Carl T Bertram, Jacob Abarca, Rick A Rehfeld, Daniel C Malone, Marlene Freeman, Raymond L Woosley
OBJECTIVES: Our objective was to compare sex and age differences in the medications dispensed in pharmacies from a large national drugstore chain. METHODS: Using a list for the 200 most commonly prescribed medicines, we assessed prescriptions dispensed by a large national chain drug store over 1 year (2002-2003). The analysis used U.S. census data adjusted for the population by sex and age and weighted by the number of pharmacies per state. Results are reported as an odds ratio (OR) of prescriptions dispensed to females and males...
June 2008: Journal of Women's Health
https://www.readbyqxmd.com/read/17578744/binding-and-oxidative-cleavage-studies-of-dna-by-mixed-ligand-co-iii-and-ni-ii-complexes-of-quinolo-3-2-b-benzodiazapine-and-1-10-phenanthroline
#12
M C Prabhakara, H S Bhojya Naik, V Krishna, H M Kumaraswamy
Two mixed ligand complexes of the type [M(phen)(2)(qbdp)](PF(6))n.xH(2)O where M = Co(III) and Ni(II), qbdp = quinolo[3,2-b] benzodiazepine and phen = 1,10-phenanthroline, n = 3 or 2, x = 2 or 3 have been synthesized and characterized by employing analytical and spectral methods. The DNA binding property of the complexes with calf thymus-DNA has been investigated by using absorption spectra, viscosity measurements as well as thermal denaturation studies. The absorption spectral results indicate that the Co(III) and Ni(II) complexes intercalate between the base pairs of the DNA tightly with intrinsic DNA binding constant of 6...
2007: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/17491537/moving-to-a-purpose-built-acute-psychiatric-unit-on-a-general-hospital-site-does-the-new-environment-produce-change-for-the-better
#13
L Feeney, A Kavanagh, B D Kelly, M Mooney
The environment of a hospital can have a significant impact on the experiences of patients. In March 2003 a new purpose built acute psychiatric admission unit opened on the site of Kilkenny General hospital, while the admission wards of the 2 local stand-alone psychiatric hospitals closed. We sought to compare admissions before and after the move, hypothesising that there would be lower levels of aggression, sedative prescribing and intoxicant abuse in the new unit. Details of 98 acute admissions that occurred during the first 3 months of 2002 were compared to 97 acute admissions that occurred during the first 3 months of 2004...
March 2007: Irish Medical Journal
https://www.readbyqxmd.com/read/17170191/drinking-drugs-and-driving-in-ireland-more-evidence-for-action
#14
P Fitzpatrick, L Daly, C P Leavy, D A Cusack
OBJECTIVE: To examine the prevalence of drug positivity among drivers suspected of driving under the influence of an intoxicant, and consequently apprehended by the police in Ireland. DESIGN: 2000 specimens were selected for drug analysis, 1000 with results under the limit for alcohol and 1000 over the limit. The limit for alcohol is 80 mg/100 ml in blood and 107 mg/100 ml in urine. Seven drugs/drug classes were examined; amphetamines, methamphetamines, benzodiazapines, cannabinoids, cocaine, opiates and methadone...
December 2006: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/16235313/benzodiazepines-alone-or-in-combination-with-antipsychotic-drugs-for-acute-psychosis
#15
REVIEW
D Gillies, A Beck, A McCloud, J Rathbone, Donna Gillies
BACKGROUND: Acute psychotic illness, especially when associated with agitated or violent behaviour, can require urgent pharmacological tranquillisation or sedation. In several countries, clinicians often use benzodiazepines (either alone or in combination with antipsychotics) for this outcome. OBJECTIVES: To estimate the effects of benzodiazepines, alone or in combination with antipsychotics, when compared to placebo or antipsychotics, to control disturbed behaviour and reduce psychotic symptoms...
2005: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/15611563/temporal-relationships-among-testosterone-production-steroidogenic-acute-regulatory-protein-star-and-p450-side-chain-cleavage-enzyme-p450scc-during-leydig-cell-aging
#16
COMPARATIVE STUDY
Lindi Luo, Haolin Chen, Barry R Zirkin
Previous studies have shown that the capacity of Leydig cells from aged (21-24-month-old) Brown Norway rats to produce testosterone is reduced from young (4-month-old) levels, and that this is correlated with reductions in steroidogenic acute regulatory protein (StAR), peripheral benzodiazapine receptor (PBR), and the levels and activities of the steroidogenic enzymes. The age(s) at which particular changes in the steroidogenic pathway occur, and the relationship of particular changes to reduced testosterone production, are not known...
January 2005: Journal of Andrology
https://www.readbyqxmd.com/read/12323392/involvement-of-the-peripheral-benzodiazepine-receptor-in-the-development-of-rheumatoid-arthritis-in-mrl-lpr-mice
#17
Estelle Bribes, Bernard Bourrie, Martine Esclangon, Sylvaine Galiegue, Hubert Vidal, Pierre Casellas
In this study, the effects of different peripheral benzodiazapine receptor ligands: PK 11195 [1-(2-chloro-phenyl)-N-methyl-N-(1-methylpropyl)-1-isoquinoline carboxamide], Ro5-4864 [7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one] and the newly described SSR 180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridozine[4,5-b] indole-1-acetamide) were analysed on the progression and severity of rheumatoid arthritis in vivo in the Mrl/lpr mice model, following chronic treatment (at 3 mg/kg, i...
September 27, 2002: European Journal of Pharmacology
https://www.readbyqxmd.com/read/11286044/new-alternative-agents-in-essential-tremor-therapy-double-blind-placebo-controlled-study-of-alprazolam-and-acetazolamide
#18
RANDOMIZED CONTROLLED TRIAL
D I Gunal, N Afşar, N Bekiroglu, S Aktan
Propranolol and primidone are widely used, effective agents in essential tremor although they are not tolerated by all patients. In the present study, the effectiveness of alprazolam, a triazole analog of benzodiazapine class, and acetazolamide, a carbonic anhydrase inhibitor, were investigated as symptomatic treatments for essential tremor. We studied 22 patients with essential tremor in a double-blind, cross-over, placebo-controlled design. The patients received in random order alprazolam, acetazolamide, primidone and placebo for four weeks, each separated by a two-week washout period...
October 2000: Neurological Sciences
https://www.readbyqxmd.com/read/11059256/-the-analysis-of-diagnoses-and-pharmacological-treatment-of-patients-on-disability-pension-due-to-depression
#19
J Jaracz
The aim of the study was to assess the diagnoses and pharmacological treatment in 80 patients with symptoms of depression in reference to the psychiatric examination due to disability pension proceedings. Diagnoses were often not in accordance with the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10). Twenty two per cent of outpatients were treated using benzodiazepines only. In the group of antidepressants, mianserin, fluoxetine and doxepine were used most often (in 12%, 12% and 11% of outpatients respectively)...
July 2000: Psychiatria Polska
https://www.readbyqxmd.com/read/10973530/gender-estrous-cycle-ovariectomy-and-ovarian-hormones-influence-the-effects-of-diazepam-on-avoidance-conditioning-in-rats
#20
COMPARATIVE STUDY
G Díaz-Véliz, S Butrón, M S Benavides, N Dussaubat, S Mora
This study examines whether the hormonal condition of the rat modifies the effects of diazepam (0.25 and 1.0 mg/kg) on avoidance conditioning and other behavioral responses. Acquisition of a conditioning avoidance response (CAR) and spontaneous motor behaviors were assessed in intact male, in intact diestrous and estrous females, and in ovariectomized (OVX) rats injected with estradiol (2 microg/rat, SC) or progesterone (5 mg/rat, SC). A higher dose (1.0 mg/kg) of diazepam significantly impaired the acquisition of CARs in diestrous, OVX, OVX + progesterone, and male rats...
August 2000: Pharmacology, Biochemistry, and Behavior
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