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https://www.readbyqxmd.com/read/28932721/clinical-significance-of-preoperative-virtual-colonoscopy-for-evaluation-of-the-proximal-colon-in-patient-with-obstructive-colorectal-cancer
#1
Jae-Hyuk Heo, Chun-Geun Ryu, Eun-Joo Jung, Jin-Hee Paik, Dae-Yong Hwang
PURPOSE: Virtual colonoscopy is the most recently developed tool for detecting colorectal cancers and polyps, but its effectiveness is limited. In our study, we compared the result of preoperative virtual colonoscopy to result of preoperative and postoperative colonoscopy. We evaluated also the accuracy of preoperative virtual colonoscopy in patients who had obstructive colorectal cancer that did not allow passage of a colonoscope. METHODS: A total of 164 patients who had undergone preoperative virtual colonoscopy and curative surgery after the diagnosis of a colorectal adenocarcinoma between November 2008 and August 2013 were pooled...
August 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28924586/effectiveness-and-safety-of-metallic-stent-for-ileocecal-obstructive-colon-cancer-a-report-of-4-cases
#2
Tatsuya Ishii, Kosuke Minaga, Satoshi Ogawa, Maiko Ikenouchi, Tomoe Yoshikawa, Takuji Akamatsu, Takeshi Seta, Shunji Urai, Yoshito Uenoyama, Yukitaka Yamashita
Background and study aims  Self-expandable metallic stents (SEMS) have been widely used for left-sided colorectal obstruction. Few studies on SEMS placement for right-sided colonic obstructions have been reported because stenting in the right colon is technically difficult, particularly in the ileocecal region. We present 4 cases of successful bridge-to-surgery stenting for ileocecal cancer. Using an endoscopic retrograde cholangiopancreatography catheter with a movable tip and a decompression tube was effective for stenting...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28892247/short-term-results-of-self-expanding-metal-stents-for-acute-malignant-large-bowel-obstruction
#3
Martin Kobborg, Malene Broholm, Erik Frostberg, Maja Jeppesen, Ismail Gögenür
INTRODUCTION: Self-expanding metal stents (SEMS) can be used as a palliative treatment or to initially decompress colon prior to definitive surgery (so called "bridge to surgery"). The purpose of this study was to investigate the efficacy and safety of SEMS used as palliation and bridge to surgery for malignant large bowel obstruction. METHOD: A multicenter retrospective study was conducted from January 2010 to December 2013 to identify patients undergoing stent placement for acute large bowel obstruction...
September 11, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28882578/managing-ulcerative-colitis-patients-with-endoscopically-invisible-low-grade-dysplasia
#4
Ben Parker, James Buchanan, Sarah Wordsworth, Satish Keshav, Bruce George, James E East
BACKGROUND AND AIMS: There is uncertainty regarding the optimal management of endoscopically invisible ("flat") low grade dysplasia in ulcerative colitis. Such a finding does not currently provide an automatic indication for colectomy; however, a recommendation of surveillance instead of surgery is controversial. The aim of this study was to determine the clinical and cost-effectiveness of colonoscopic surveillance versus colectomy for endoscopically invisible low-grade dysplasia of the colon in ulcerative colitis...
September 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28876454/oxaliplatin-induced-increase-in-splenic-volume-irreversible-change-after-adjuvant-folfox
#5
Takuma Iwai, Takeshi Yamada, Michihiro Koizumi, Seiichi Shinji, Yasuyuki Yokoyama, Goro Takahashi, Kohki Takeda, Keisuke Hara, Keiichiro Ohta, Eiji Uchida
BACKGROUND AND OBJECTIVES: Oxaliplatin can cause hepatic sinusoidal obstruction syndrome (SOS). SOS can cause chemotherapy-related adverse effects or morbidity after liver resection. Conventionally, SOS is diagnosed using liver biopsy. Recently, it was reported that increased splenic volume (SV) can be used to detect SOS. In this study, we evaluated the changes in SV during adjuvant chemotherapy. METHODS: We enrolled 103 consecutive patients with stage III and high-risk stage II colorectal cancer treated with mFOLFOX6 (n = 37) or oral fluorouracil and leucovorin (n = 66) after curative surgery...
September 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28868482/self-expandable-metal-stents-for-colorectal-cancer-from-guidelines-to-clinical-practice
#6
Maria Pia Costa Santos, Carolina Palmela, Rosa Ferreira, Elídio Barjas, António Alberto Santos, Rui Maio, Marília Cravo
INTRODUCTION: Colonic self-expandable metal stent placement is widely used for palliation of obstructive colorectal cancer. The European recommendations for stent placement as a bridge to elective surgery in obstructive colorectal cancer were recently reviewed. The aim of this study was to evaluate the efficacy and safety of stent placement in obstructive colorectal cancer and to discuss these recent guidelines. MATERIALS AND METHODS: Demographic characteristics, procedure indications, complications and final outcome in patients with obstructive colorectal cancer who underwent endoscopic stent placement between January 2012 and June 2015 were retrospectively analyzed...
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28844781/comparison-of-efficacies-of-the-self-expandable-metallic-stent-versus-transanal-drainage-tube-and-emergency-surgery-for-malignant-left-sided-colon-obstruction
#7
Jun Kawachi, Hiroyuki Kashiwagi, Rai Shimoyama, Naoko Isogai, Ryuta Fukai, Katsunori Miyake, Hideto Egashira, Ayumu Sugitani, Hidemitsu Ogino
BACKGROUND/OBJECTIVE: Patients with left-sided malignant colorectal obstruction require emergency treatment. Emergency stoma surgery has traditionally been recommended, however many stomas became permanent, decreasing patient quality of life. Recently, self-expandable metallic stents (SEMS) and transanal decompression tubes (TDT) have become widely used decompression methods to avoid stoma surgery. In this study, we evaluated: 1) the efficacy of SEMS compared with TDT and emergency surgery (ES) to avoid permanent stomas; and 2) the safety and success rate of each treatment...
August 24, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28840326/prophylactic-pelvic-drainage-after-rectal-resection-with-extraperitoneal-anastomosis-is-it-worthwhile-a-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Benjamin Menahem, Antoine Vallois, Arnaud Alves, Jean Lubrano
BACKGROUND: The role of prophylactic pelvic drainage in reducing the postoperative complication rate after rectal surgery remains unclear and controversial. OBJECTIVE: This review and meta-analysis of prospective randomized controlled trials was performed to determine whether drainage of the extraperitoneal anastomosis after rectal surgery impacts the postoperative complication rate. STUDY ELIGIBILITY CRITERIA: Study eligibility criteria included randomized controlled trials comparing prophylactic pelvic drainage after rectal surgery...
August 24, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28836258/-application-of-transanal-total-mesorectal-excision-in-radical-surgery-for-rectal-cancer
#9
Liu He, Yi Xiao
Transanal total mesorectal excision (taTME) is a novel operative approach of the radical surgery for rectal cancer, and has been a hot topic in colorectal surgery for years. TaTME aims to solve some problems from previous TME, such as exposure of peripheral mid-lower rectal space, judge of distal cutting margin, and to carry out completely minimal invasive operation. According to the degree of completion of different surgical approach, taTME can be divided into laparoscopic assisted taTME (hybrid taTME) and fully through the anal approach to complete the taTME (pure taTME)...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28813196/hepatic-parenchymal-heterogeneity-as-a-marker-for-oxaliplatin-induced-sinusoidal-obstruction-syndrome-correlation-with-treatment-response-of-colorectal-cancer-liver-metastases
#10
Na Yeon Han, Beom Jin Park, Kyung Sook Yang, Min Ju Kim, Deuk Jae Sung, Ki Choon Sim, Sung Bum Cho
OBJECTIVE: The objective of our study was to evaluate the influence of oxaliplatin-based chemotherapy (OBC)-induced hepatic parenchymal heterogeneity detected on contrast-enhanced CT scans on response of liver metastasis. We chose to study hepatic parenchymal heterogeneity on the basis of the assumption that hepatic parenchymal heterogeneity may indicate the presence of chemotherapy-induced sinusoidal obstruction syndrome (SOS). MATERIALS AND METHODS: For this retrospective study, 104 patients with hepatic metastases from colorectal cancer (male-female ratio, 66:38; age range, 20-80 years) who had undergone OBC and serial CT studies were consecutively registered...
August 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28811829/metabolomics-analysis-for-defining-serum-biochemical-markers-in-colorectal-cancer-patients-with-qi-deficiency-syndrome-or-yin-deficiency-syndrome
#11
Fangfang Tao, Ping Lü, Chunbo Xu, Mengmeng Zheng, Wenhong Liu, Minhe Shen, Shanming Ruan
Colorectal cancer is one of the leading causes of tumor-associated death, and traditional Chinese medicine (TCM) classifies colorectal cancer into various subtypes mainly according to the symptomatic pattern identification (ZHENG). Here, we investigated the difference in metabolic profiles of serum by comparing colorectal cancer subjects with Nondeficiency (ND), Qi deficiency (QD), and Yin deficiency (YD). The ratio of subjects with carcinoembryonic antigen (CEA) was higher in YD pattern, and the ratio of subjects with carbohydrate antigen 19-9 (CA19-9) was higher both in YD and in QD, compared with ND...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28810253/outcomes-of-self-expanding-metal-stents-in-malignant-colonic-obstruction-are-independent-of-location-or-length-of-the-stenosis-results-of-a-retrospective-single-center-series
#12
Paul K Schoonbeek, Pim Genzel, Eline H van den Berg, O Aart van Dobbenburgh, Frank Ter Borg
AIM: To evaluate the length and location of stenosis in the colon as predictors of technical and clinical outcomes of stent placement in patients presenting with obstructive colorectal cancer. METHODS: A prospective single-center cohort study of patients treated with a colonic stent for malignant obstruction, regardless of stenosis length or location. Stenosis length was assessed globally on the appropriate CT slice as well as by 3D CT reconstruction. We analyzed whether outcomes were different in patients with a right sided-tumor and/or a stenosis >4 cm long...
August 16, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28806761/transcriptome-analysis-of-pdgfr%C3%AE-cells-identifies-t-type-ca2-channel-cacna1g-as-a-new-pathological-marker-for-pdgfr%C3%AE-cell-hyperplasia
#13
Se Eun Ha, Moon Young Lee, Masaaki Kurahashi, Lai Wei, Brian G Jorgensen, Chanjae Park, Paul J Park, Doug Redelman, Kent C Sasse, Laren S Becker, Kenton M Sanders, Seungil Ro
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. PDGFRα+ cells directly interact with interstitial cells of Cajal (ICC) and smooth muscle cells (SMC) in gastrointestinal smooth muscle tissue. These three cell types, SMC, ICC, and PDGFRα+ cells (SIP cells), form an electrical syncytium, which dynamically regulates gastrointestinal motility. We have previously reported the transcriptomes of SMC and ICC...
2017: PloS One
https://www.readbyqxmd.com/read/28790448/lrlshmda-laplacian-regularized-least-squares-for-human-microbe-disease-association-prediction
#14
Fan Wang, Zhi-An Huang, Xing Chen, Zexuan Zhu, Zhenkun Wen, Jiyun Zhao, Gui-Ying Yan
An increasing number of evidences indicate microbes are implicated in human physiological mechanisms, including complicated disease pathology. Some microbes have been demonstrated to be associated with diverse important human diseases or disorders. Through investigating these disease-related microbes, we can obtain a better understanding of human disease mechanisms for advancing medical scientific progress in terms of disease diagnosis, treatment, prevention, prognosis and drug discovery. Based on the known microbe-disease association network, we developed a semi-supervised computational model of Laplacian Regularized Least Squares for Human Microbe-Disease Association (LRLSHMDA) by introducing Gaussian interaction profile kernel similarity calculation and Laplacian regularized least squares classifier...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28781299/an-analysis-of-emergency-department-visits-and-the-survival-rate-for-colorectal-cancer-patients-a-nationwide-population-based-study
#15
Pei-Ling Tang, Hong-Tai Chang, Chin-Chang Cheng, Hung-Chih Chen, Shyh-Ming Kuo, Kuan-Yin Hsiao, Kuo-Chen Chang
Objective We examined the general characteristics, survival rate, and most common reasons for visiting the emergency department (ED) among colorectal cancer patients in Taiwan. We performed a population-based retrospective study and used data sourced from the National Health Insurance Research Database (NHIRD). Methods The colorectal cancer patient population, their diagnosis, and their medical management at the ED were identified using the Longitudinal Health Insurance Database 2000 (HV) codes and International Classification of Diseases, Ninth Revision, Clinical Modification system...
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28768520/colorectal-cancer-in-a-patient-with-intestinal-schistosomiasis-a-case-report-from-kilimanjaro-christian-medical-center-northern-zone-tanzania
#16
Ayesiga M Herman, Alfred Kishe, Heri Babu, Hilary Shilanaiman, Murad Tarmohamed, Jay Lodhia, Patrick Amsi, Jeremia Pyuza, Alex Mremi, Amos Mwasamwaja, Mramba Nyindo, Kondo Chilonga, David Msuya
BACKGROUND: Colorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. Among all species Schistosoma japonicum has been more linked to development of colorectal cancer as compared to Schistosoma mansoni due to absence of population-based studies to support the association. Despite the weak evidence, some cases have been reported associating S. mansoni with development of colorectal cancer...
August 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28761871/the-usefulness-of-intraoperative-colonic-irrigation-and-primary-anastomosis-in-patients-requiring-a-left-colon-resection
#17
Youngki Hong, Soomin Nam, Jung Gu Kang
PURPOSE: The aim of this study is to assess the short-term outcome of intraoperative colonic irrigation and primary anastomosis and to suggest the usefulness of the procedure when a preoperative mechanical bowel preparation is inappropriate. METHODS: This retrospective study included 38 consecutive patients (19 male patients) who underwent intraoperative colonic irrigation and primary anastomosis for left colon disease between January 2010 and December 2016. The medical records of the patients were reviewed to evaluate the patients' characteristics, operative data, and postoperative short-term outcomes...
June 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28761765/endoscopic-stenting-as-bridge-to-surgery-versus-emergency-resection-for-left-sided-malignant-colorectal-obstruction-an-updated-meta-analysis
#18
REVIEW
Niccolò Allievi, Marco Ceresoli, Paola Fugazzola, Giulia Montori, Federico Coccolini, Luca Ansaloni
INTRODUCTION: Emergency resection represents the traditional treatment for left-sided malignant obstruction. However, the placement of self-expanding metallic stents and delayed surgery has been proposed as an alternative approach. The aim of the current meta-analysis was to review the available evidence, with particular interest for the short-term outcomes, including a recent multicentre RCT. METHODS: We considered randomized controlled trials comparing stenting as a bridge to surgery and emergency surgery for the management of left-sided malignant large bowel obstruction, performing a systematic review in MEDLINE, PubMed database, and the Cochrane libraries...
2017: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28760355/decreasing-readmissions-by-focusing-on-complications-and-underlying-reasons
#19
Cigdem Benlice, Dilara Seyidova-Khoshknabi, Luca Stocchi, Tracy Hull, Scott Steele, Emre Gorgun
BACKGROUND: To analyze demographics and outcomes of patients focusing on 30-day readmission status and identify procedure-specific risk factors. METHODS: Patients undergoing abdominal colorectal surgery (2011-2013) were identified Demographics and outcomes including in-hospital complications were compared based on readmission status. RESULTS: A total of 6637 patients were identified with a mean age of 51.2(±17.1) years. Seven hundred and seventy five(11...
July 21, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28755255/magnetic-resonance-defecography-versus-videodefecography-in-the-study-of-obstructed-defecation-syndrome-is-videodefecography-still-the-test-of-choice-after-50-years
#20
G P Martín-Martín, J García-Armengol, J V Roig-Vila, A Espí-Macías, V Martínez-Sanjuán, M Mínguez-Pérez, M Á Lorenzo-Liñán, C Mulas-Fernández, F X González-Argenté
BACKGROUND: The aim of the present study was to evaluate the diagnostic accuracy of magnetic resonance (MR) defecography and compare it with videodefecography in the evaluation of obstructed defecation syndrome. METHODS: This was a prospective cohort test accuracy study conducted at one major tertiary referral center on patients with a diagnosis of obstructed defecation syndrome who were referred to the colorectal surgery clinic in a consecutive series from 2009 to 2012...
July 28, 2017: Techniques in Coloproctology
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