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Colorectal obstruction

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https://www.readbyqxmd.com/read/29774103/bevacizumab-exacerbates-sinusoidal-obstruction-syndrome-sos-in-the-animal-model-and-increases-mmp-9-production
#1
Azin Jafari, Hanno Matthaei, Sven Wehner, Tolga Tonguc, Jörg C Kalff, Steffen Manekeller
Background: Thanks to modern multimodal treatment the ouctome of patients with colorectal cancer has experienced significant improvements. As a downside, agent specific side effects have been observed such as sinusoidal obstruction syndrome (SOS) after oxaliplatin chemotherapy (OX). Bevazicumab targeting VEGF is nowadays comprehensively used in combination protocols with OX but its impact on hepatotoxicity is thus far elusive and focus of the present study. Results: After MCT administration 67% of animals developed SOS...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29756013/colonic-stent-versus-emergency-surgery-as-treatment-of-malignant-colonic-obstruction-in-the-palliative-setting-a-systematic-review-and-meta-analysis
#2
REVIEW
Igor Braga Ribeiro, Wanderley Marques Bernardo, Bruno da Costa Martins, Diogo Touriani Hourneau de Moura, Elisa Ryoka Baba, Iatagan Rocha Josino, Nelson Tomio Miyahima, Martin Andrés Coronel Cordero, Thiago Arantes de Carvalho Visconti, Edson Ide, Paulo Sakai, Eduardo Guimarães Hourneau de Moura
Background and study aims : Colorectal cancer (CRC) is the third most common malignancy and the third leading cause of cancer death worldwide. Malignant colonic obstruction (MCO) due to CRC occurs in 8 % to 29 % of patients.The aim of this study was to perform a systematic review and meta-analysis of RCTs comparing colonic SEMS versus emergency surgery (ES) for MCO in palliative patients. This was the first systematic review that included only randomized controlled trials in the palliative setting...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29755780/appendiceal-diverticulosis-a-harbinger-of-underlying-primary-appendiceal-adenocarcinoma
#3
Jia Lin Ng, Shing Lih Wong, Ronnie Mathew
Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29746337/bowel-obstruction-and-ventral-hernia-after-laparoscopic-versus-open-surgery-for-rectal-cancer-in-a-randomized-trial-color-ii
#4
Josefin Petersson, Thomas W Koedam, H Jaap Bonjer, John Andersson, Eva Angenete, David Bock, Miguel A Cuesta, Charlotte L Deijen, Alois Fürst, Antonio M Lacy, Jacob Rosenberg, Eva Haglind
OBJECTIVE: The aim of this study was to evaluate the risk of bowel obstruction, incisional, and parastomal hernia following laparoscopic versus open surgery for rectal cancer. SUMMARY BACKGROUND DATA: Laparoscopic surgery for rectal cancer has been adopted worldwide, after trials reported similar oncological outcomes compared with open surgery. Little is known about long-term morbidity, including bowel obstruction, incisional, and parastomal hernia following surgery...
May 9, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29742862/trephine-transverse-colostomy-is-effective-for-patients-who-have-previously-undergone-rectal-surgery
#5
Seung-Seop Yeom, Chan Wook Kim, Sung Woo Jung, Se Heon Oh, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
PURPOSE: Colostomy creation is an essential procedure for colorectal surgeons, but the preferred method of colostomy varies by surgeon. We compared the outcomes of trephine colostomy creation with open those for the (laparotomy) and laparoscopic methods and evaluated appropriate indications for a trephine colostomy and the advantages of the technique. METHODS: We retrospectively evaluated 263 patients who had undergone colostomy creation by trephine, open and laparoscopic approaches between April 2006 and March 2016...
April 2018: Annals of Coloproctology
https://www.readbyqxmd.com/read/29739772/associations-of-grip-strength-with-cardiovascular-respiratory-and-cancer-outcomes-and-all-cause-mortality-prospective-cohort-study-of-half-a-million-uk-biobank-participants
#6
Carlos A Celis-Morales, Paul Welsh, Donald M Lyall, Lewis Steell, Fanny Petermann, Jana Anderson, Stamatina Iliodromiti, Anne Sillars, Nicholas Graham, Daniel F Mackay, Jill P Pell, Jason M R Gill, Naveed Sattar, Stuart R Gray
OBJECTIVE: To investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score. DESIGN: Prospective population based study. SETTING: UK Biobank. PARTICIPANTS: 502 293 participants (54% women) aged 40-69 years. MAIN OUTCOME MEASURES: All cause mortality as well as incidence of and mortality from cardiovascular disease, respiratory disease, chronic obstructive pulmonary disease, and cancer (all cancer, colorectal, lung, breast, and prostate)...
May 8, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29719419/emergency-treatment-of-complicated-colorectal-cancer
#7
Giovanni Domenico Tebala, Andrea Natili, Antonio Gallucci, Gioia Brachini, Abdul Qayyum Khan, Domenico Tebala, Andrea Mingoli
Aim: To find evidence to suggest the best approach in patients admitted as an emergency for complicated colorectal cancer. Methods: The medical records of 131 patients admitted as an emergency with an obstructing, perforated, or bleeding colorectal cancer to Noble's Hospital, Isle of Man, and the Umberto I University Hospital, Rome, were retrospectively evaluated. Patients were divided in 3 groups on the basis of the emergency treatment they received, namely 1) immediate resection, 2) damage control procedure and elective or semielective resection, and 3) no radical treatment...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29700776/a-novel-application-of-indocyanine-green-immunofluorescence-in-emergent-colorectal-surgery
#8
Deborah S Keller, Richard Boulton, Manuel Rodriguez-Justo, Richard Cohen, Manish Chand
Here, we report on the feasibility of ICG fluorescence imaging to localize lesions in emergent minimally invasive surgery. A 49-year old female presented to the emergency department with a previously unknown malignant bowel obstruction. She was taken emergently to the operating room for a laparoscopic extended right hemicolectomy, based on tumor location from imaging. With intraoperative difficulty localizing the lesion, an on-table colonoscopy was performed. When the tumor was encountered, peritumoral ICG injections were performed, and the fluorescence lymphoscintigraphy was performed intraoperatively in an attempt to visualize the primary tumor laparoscopically...
April 26, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29696058/our-20-year-experience-with-experimental-colonic-anastomotic-healing
#9
REVIEW
Dimitrios Raptis, Manousos-Georgios Pramateftakis, Ioannis Kanellos
Aim: To present our experience with experimental colonic anastomoses and compare it with the results of other experienced researchers. Materials and Method: The published experimental studies of our research group up to 1996, as well as results of other researchers in this field, are demonstrated and discussed. Different actions of administered substances on the anastomotic healing were compared and represented. Various chemotherapeutic agents were evaluated in experimental models without colorectal cancer as independent risk factors for the anastomotic healing...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29686820/biofeedback-efficacy-to-improve-clinical-symptoms-and-endoscopic-signs-of-solitary-rectal-ulcer-syndrome
#10
Mojgan Forootan, Masood Shekarchizadeh, Hamedreza Farmanara, Ahmad Reza Shekarchizadeh Esfahani, Mansooreh Shekarchizadeh Esfahani
Solitary rectal ulcer syndrome (SRUS) is often resistant to medical and surgical treatment. This study assessed the effect of biofeedback in decreasing the symptoms and the healing of endoscopic signs in SRUS patients. Before starting the treatment, endoscopy and colorectal manometry was performed to evaluate dyssynergic defecation. Patients were followed every four weeks, and during each visit their response to treatment was evaluated regarding to manometry pattern. After at least 50% improvement in manometry parameters, recipients underwent rectosigmoidoscopy...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29679151/comparisons-of-the-surgical-outcomes-and-medical-costs-between-transferred-and-directly-admitted-patients-diagnosed-with-intestinal-obstruction-in-an-american-tertiary-referral-center
#11
Xian Hua Gao, Hanumant Chouhan, Emre Gorgun, Luca Stocchi, Gokhan Ozuner
PURPOSE: Intestinal obstruction is a leading cause of patient mortality and the most common reason for emergent operation in colorectal surgery. The influence of inter-hospital transfer on patients' outcomes varies greatly in different diseases. We aimed to compare the surgical outcomes and medical costs between transferred and directly admitted patients diagnosed with intestinal obstruction in an American tertiary referral center. METHODS: All intestinal obstruction patients operated in Cleveland Clinic from Jan 2012 to Dec 2016 were collected from a prospectively maintained database...
April 20, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29669684/impact-on-surgical-and-oncological-results-of-the-use-of-colonic-stents-as-a-bridge-to-surgery-for-potentially-curable-occlusive-colorectal-neoplasms
#12
Antònia Crespí-Mir, Juan Manuel Romero-Marcos, Anabel de la Llave-Serralvo, Carlos Dolz-Abadía, José Andrés Cifuentes-Ródenas
INTRODUCTION: The outcomes of patients treated with colonic stents as a bridge to surgery (BTS) have recently been questioned in terms of safety and long-term oncologic outcomes. The aim of this study is to evaluate the effects on surgical and oncologic outcomes of colonic stents as a BTS for potentially resectable obstructive colorectal cancer. METHODS: We conducted a retrospective analysis of patients operated on for potentially resectable obstructive colorectal cancer with or without distant disease between September 2002 and October 2015, comparing the patients treated with a colonic stent as a BTS (Stent group) with those directly operated on (Surgery group)...
April 15, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29663068/prevalence-of-colorectal-cancer-in-acute-uncomplicated-diverticulitis-and-the-role-of-the-interval-colonoscopy
#13
Yock Teck Nicholas Soh, Kai Ann Daryl Chia, Nan Zun Teo, Jian Ming Calvin Ong, Ramesh Wijaya
PURPOSE: Although computed tomography (CT) is the imaging modality of choice for diagnosing colonic diverticulitis today, there remains a risk of colorectal cancer mimicking diverticulitis due to overlapping imaging features. Current practice guidelines recommend interval colonoscopy after diverticulitis to exclude occult malignancy. Some authors have suggested that this may be unnecessary in patients with uncomplicated diverticulitis. The aim of our study was to examine the prevalence of occult colorectal cancer in patients with CT-proven acute uncomplicated diverticulitis in an Asian population...
April 16, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29662933/endometriosis-a-rare-cause-of-large-bowel-obstruction
#14
Gonçalo Alexandrino, Luís Carvalho Lourenço, Rita Carvalho, Cisaltina Sobrinho, David Valadas Horta, Jorge Reis
Large bowel obstruction can result in significant morbidity and mortality, especially in cases of acute complete obstruction. There are many possible causes, the most common in adults being colorectal cancer. Endometriosis is a benign disease, and the most affected extragenital location is the bowel, especially the rectosigmoid junction. However, transmural involvement and acute occlusion are very rare events. We report an exceptional case of acute large bowel obstruction as the initial presentation of endometriosis...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29661283/2-octylcyanoacrylate-for-the-prevention-of-anastomotic-leak
#15
Anthony B Costales, Deepa Patil, Anny Mulya, John P Kirwan, Chad M Michener
BACKGROUND: Anastomotic leak after colorectal surgery is a significant cause of morbidity and mortality. The aim of this study was to evaluate the impact of a reinforced colo-colonic anastomosis with tissue adhesive, 2-octylcyanoacrylate (2-OCA), on the integrity of anastomotic healing as measured by anastomotic bursting pressure. METHODS: Sixty-eight female Sprague-Dawley rats underwent a rectosigmoid colon transection and a sutured end-to-end anastomosis followed by randomization to receive no further intervention or reinforcement with the tissue adhesive, 2-OCA...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29650936/-review-of-the-efficacy-of-endoscopic-stenting-for-malignant-colorectal-obstruction-at-tokyo-metropolitan-ohtsuka-hospital
#16
Taiki Masuda, Sakiko Yabe, Eisuke Yamamoto, Kenta Kobayashi, Tetsunori Yoshimura
BACKGROUND: The use of self-expandable metallic stent(SEMS)was first authorized by insurance and became available nationwide in Japan in 2012. Insertion of SEMS for colorectal obstruction due to colorectal cancer is useful as a bridge to surgery(BTS)approach and releases stenosis as palliative care. AIM: To assess the outcomes of SEMS placement for colorectal obstruction. PATIENTS AND METHODS: A total of 14 patients were treated with SEMS between April 2014 and March 2017...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650907/-cases-of-oncologic-emergency-associated-with-colorectal-cancer
#17
Yukihisa Nishimura, Masayuki Yubakami, Nobuyuki Watanabe, Yutaka Kondo, Kazuto Ujiie, Momoko Todo, Yoshitaka Nakamura, Kiyoto Atsuji, Akihiro Yamaguchi, Naoki Kakihara, Osamu Ikawa, Hiroki Taniguchi
The clinical condition of oncologic emergency associated with colorectal cancer includes hemorrhage, perforation and obstruction. Obstructive colorectal cancer is an oncologic emergency commonly observed in our daily clinical practice. Colonic stent placement for obstructive colorectal cancer is relatively easy and safe and may be considered as an effective treatment method that enables favorable intestinal decompression preoperatively and one-stage resection. Colonic stent use can be a bridge to surgery, enabling shorter duration of hospitalization, and reduced postoperative complications, and colostomy rates, as compared to emergency surgery...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650363/chemotherapy-versus-chemoradiotherapy-after-surgery-and-preoperative-chemotherapy-for-resectable-gastric-cancer-critics-an-international-open-label-randomised-phase-3-trial
#18
Annemieke Cats, Edwin P M Jansen, Nicole C T van Grieken, Karolina Sikorska, Pehr Lind, Marianne Nordsmark, Elma Meershoek-Klein Kranenbarg, Henk Boot, Anouk K Trip, H A Maurits Swellengrebel, Hanneke W M van Laarhoven, Hein Putter, Johanna W van Sandick, Mark I van Berge Henegouwen, Henk H Hartgrink, Harm van Tinteren, Cornelis J H van de Velde, Marcel Verheij
BACKGROUND: Both perioperative chemotherapy and postoperative chemoradiotherapy improve survival in patients with resectable gastric cancer from Europe and North America. To our knowledge, these treatment strategies have not been investigated in a head to head comparison. We aimed to compare perioperative chemotherapy with preoperative chemotherapy and postoperative chemoradiotherapy in patients with resectable gastric adenocarcinoma. METHODS: In this investigator-initiated, open-label, randomised phase 3 trial, we enrolled patients aged 18 years or older who had stage IB- IVA resectable gastric or gastro-oesophageal adenocarcinoma (as defined by the American Joint Committee on Cancer, sixth edition), with a WHO performance status of 0 or 1, and adequate cardiac, bone marrow, liver, and kidney function...
May 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29643958/outcomes-and-complications-of-self-expanding-metal-stent-placement-for-malignant-colonic-obstruction-in-a-single-center-study
#19
Rafał Stankiewicz, Sławomir Kozieł, Jan Pertkiewicz, Krzysztof Zieniewicz
Introduction: Approximately 20% of cases of colorectal cancer are accompanied by acute colonic obstruction. While emergency colonic surgery is associated with high mortality and morbidity rates, placement of a self-expanding metal stent (SEMS) has been suggested as an alternative method. The SEMS placement can serve as either a definitive treatment in palliative cases or a bridge to surgery. Aim: To summarize the experience of our center in the treatment of malignant colonic obstruction using SEMS placement...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29594413/risk-factors-for-postoperative-pneumonia-in-elderly-patients-with-colorectal-cancer-a-sub-analysis-of-a-large-multicenter-case-control-study-in-japan
#20
Masatoshi Kochi, Takao Hinoi, Hiroaki Niitsu, Hideki Ohdan, Fumio Konishi, Yusuke Kinugasa, Takaya Kobatake, Masaaki Ito, Masafumi Inomata, Toshimasa Yatsuoka, Takashi Ueki, Jo Tashiro, Shigeki Yamaguchi, Masahiko Watanabe
PURPOSE: Postoperative pneumonia affects the length of stay and mortality after surgery in elderly patients with colorectal cancer (CRC). We aimed to determine the risk factors of postoperative pneumonia in elderly patients with CRC, and to evaluate the impact of laparoscopic surgery on elderly patients with CRC. METHODS: We retrospectively investigated 1473 patients ≥ 80 years of age who underwent surgery for stage 0-III CRC between 2003 and 2007. Using a multivariate analysis, we determined the risk factors for pneumonia occurrence from each baseline characteristic...
March 29, 2018: Surgery Today
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