Sven Sandin, Benjamin H K Yip, Weiyao Yin, Lauren A Weiss, Joseph D Dougherty, Stuart Fass, John N Constantino, Zhu Hailin, Tychele N Turner, Natasha Marrus, David H Gutmann, Stephan J Sanders, Benjamin Christoffersson
IMPORTANCE: Autism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, no large population-based study has provided estimates of heritability by sex. OBJECTIVE: To estimate the sex-specific heritability of ASD. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based, retrospective analysis using national health registers of nontwin siblings and cousins from Sweden born between January 1, 1985, and December 31, 1998, with follow-up to 19 years of age...
April 17, 2024: JAMA Psychiatry