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https://www.readbyqxmd.com/read/29793060/a-computational-framework-for-the-detection-of-subcortical-brain-dysmaturation-in-neonatal-mri-using-3d-convolutional-neural-networks
#1
Rafael Ceschin, Alexandria Zahner, William Reynolds, Jenna Gaesser, Giulio Zuccoli, Cecilia W Lo, Vanathi Gopalakrishnan, Ashok Panigrahy
Deep neural networks are increasingly being used in both supervised learning for classification tasks and unsupervised learning to derive complex patterns from the input data. However, the successful implementation of deep neural networks using neuroimaging datasets requires adequate sample size for training and well-defined signal intensity based structural differentiation. There is a lack of effective automated diagnostic tools for the reliable detection of brain dysmaturation in the neonatal period, related to small sample size and complex undifferentiated brain structures, despite both translational research and clinical importance...
May 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29792542/defining-bladder-health-in-women-and-girls-implications-for-research-clinical-practice-and-public-health-promotion
#2
Emily S Lukacz, Tamara G Bavendam, Amanda Berry, Cynthia S Fok, Sheila Gahagan, Patricia S Goode, Cecilia T Hardacker, Jeni Hebert-Beirne, Cora E Lewis, Jessica Lewis, Lisa Kane Low, Jerry L Lowder, Mary H Palmer, Ariana L Smith, Sonya S Brady
BACKGROUND: Bladder health in women and girls is poorly understood, in part, due to absence of a definition for clinical or research purposes. This article describes the process used by a National Institutes of Health funded transdisciplinary research team (The Prevention of Lower Urinary Tract Symptoms [PLUS] Consortium) to develop a definition of bladder health. METHODS: The PLUS Consortium identified currently accepted lower urinary tract symptoms (LUTS) and outlined elements of storage and emptying functions of the bladder...
May 24, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29792518/it-is-the-family-context-that-matters-concurrent-and-predictive-effects-of-aspects-of-parent-child-interaction-on-video-gaming-related-problems
#3
Angel Yee-Lam Li, Barbara Chuen-Yee Lo, Cecilia Cheng
Studies have shown that children frequently experiencing poor parent-child interaction are prone to video gaming-related problems, but it is unclear which specific aspects of such an interaction play a predictive role in the problems. To extend previous research that relies primarily on the self-report method to assess parent-child interaction, we conducted a longitudinal, mixed-methods study. In a laboratory setting, three major aspects of interaction (i.e., affectivity, cohesiveness, and parental behavior) were observed in 241 parent-child dyads (Children: 43 percent female, age range = 8-15, Mage  = 12...
May 24, 2018: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29792364/current-evidence-in-the-stability-of-medicines-in-dose-administration-aids-implications-for-patient-safety
#4
Estela R García, Stefanie Thalhauser, Hèctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
As the elderly population and polypharmacy are increasing, it is predicted that interventions to enhance medication adherence, as dose administration aids (DAA), will grow too. One of the limitations of repackaging medicines into DAA is to assure the stability of medicines, and, therefore, their quality, efficacy and safety. Area covered: This article collects and summarises data of all the stability studies of repackaged medicines into DAAs, as the result of a computerized search in databases (PubMed, Google Scholar, SciELO, and reference texts related to the field...
May 24, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29791746/molecular-and-cellular-characterization-of-nachr-subtypes-in-the-arcuate-nucleus-of-the-mouse-hypothalamus
#5
Cali A Calarco, Zhiying Li, Seth R Taylor, Somin Lee, Wenliang Zhou, Jeffrey M Friedman, Yann S Mineur, Cecilia Gotti, Marina R Picciotto
Nicotine, acting through nicotinic acetylcholine receptors (nAChRs), increases the firing rate of both orexigenic agouti-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), yet nicotine and other nAChR agonists decrease food intake in mice. Viral-mediated knockdown of β4 nAChR subunit in all neuronal cell types in the ARC prevents the nicotinic agonist cytisine from decreasing food intake, but it is not known whether the β4 subunit is selectively expressed in anorexogenic neurons or how other nAChR subtypes are distributed in this nucleus...
May 23, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29791641/suicidal-ideation-and-attempt-of-older-women-in-northeastern-brazil
#6
Raimunda Magalhães da Silva, Girliani Silva de Sousa, Luiza Jane Eyre de Souza Vieira, José Manuel Peixoto Caldas, Maria Cecília de Souza Minayo
OBJECTIVE: to associate the life experiences of older women from the Northeast of Brazil with their suicidal ideation and attempts. METHOD: Qualitative study with fourteen older adults from Piripiri (PI), Teresina (PI), Fortaleza (CE) and Recife (PE) who were interviewed between November 2013 and July 2014. The organization of data originated the themes: experiences of abuse throughout their lives; marital fractures and social isolation; weakened motherhood. RESULTS: The women were born and lived most of their life in the countryside, amid poverty and social exclusion...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791550/inclusion-and-exclusion-criteria-in-research-studies-definitions-and-why-they-matter
#7
Cecilia Maria Patino, Juliana Carvalho Ferreira
No abstract text is available yet for this article.
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29790393/assistive-technology-policy-a-position-paper-from-the-first-global-research-innovation-and-education-on-assistive-technology-great-summit
#8
Malcolm MacLachlan, David Banes, Diane Bell, Johan Borg, Brian Donnelly, Michael Fembek, Ritu Ghosh, Rosie Gowran, Emma Hannay, Diana Hiscock, Evert-Jan Hoogerwerf, Tracey Howe, Friedbert Kohler, Natasha Layton, Siobhán Long, Hasheem Mannan, Gubela Mji, Thomas Odera Ongolo, Katherine Perry, Cecilia Pettersson, Jessica Power, Vinicius Delgado Ramos, Lenka Slepičková, Emma Smith, Kiu Tay-Teo, Priscille Geiser, Hilary Hooks
Increased awareness, interest and use of assistive technology (AT) presents substantial opportunities for many citizens to become, or continue being, meaningful participants in society. However, there is a significant shortfall between the need for and provision of AT, and this is patterned by a range of social, demographic and structural factors. To seize the opportunity that assistive technology offers, regional, national and sub-national assistive technology policies are urgently required. This paper was developed for and through discussion at the Global Research, Innovation and Education on Assistive Technology (GREAT) Summit; organized under the auspices of the World Health Organization's Global Collaboration on Assistive Technology (GATE) program...
May 23, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29790322/-editorial-a-year-full-of-news-for-italian-nurses
#9
Cecilia Sironi
No abstract text is available yet for this article.
January 2018: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29789711/physical-activity-but-not-sedentary-time-is-associated-with-vitamin-d-status-in-adolescents-study-of-cardiovascular-risk-in-adolescents-erica
#10
Ana Carla Moreira da Silva, Felipe Vogt Cureau, Cecília Lacroix de Oliveira, Denise Tavares Giannini, Katia Vergetti Bloch, Maria Cristina Caetano Kuschnir, Eliane Said Dutra, Beatriz D Schaan, Kênia Mara Baiocchi de Carvalho
BACKGROUND/OBJECTIVES: The association between active lifestyle components and vitamin D status in adolescents remains relatively unexplored. We aimed to investigate independent and joint associations of moderate-to-vigorous physical activity (MVPA) and screen time with serum 25-hydroxyvitamin D [25(OH)D] concentrations in adolescents. METHODS: This multicenter cross-sectional study involved 1152 Brazilian adolescents (age 12-17 years). Serum 25(OH)D was measured in a single laboratory and categorized as ≤20, 21-29, or ≥30 ng/mL...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29787893/effect-of-glycerol-on-the-physical-and-mechanical-properties-of-thin-gellan-gum-films-for-oral-drug-delivery
#11
Patrizia Paolicelli, Stefania Petralito, Gabriele Varani, Martina Nardoni, Settimio Pacelli, Laura Di Muzio, Jacopo Tirillò, Cecilia Bartuli, Stefania Cesa, Maria Antonietta Casadei, Alessandra Adrover
In this work, deacylated gellan gum and the plasticizer glycerol were used as primary components for the preparation of thin films intended for the oral delivery of therapeutic molecules. The samples were prepared by a solvent casting method and characterized for their thickness, tensile properties, swelling ability, mucoadhesion capacity and uniform drug distribution. The amount of glycerol was varied from 20% to 75% w/w in order to obtain films with tunable mechanical properties and high drug loading efficiency...
May 19, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29787881/a-long-term-follow-up-after-radiosurgery-of-papillary-tumour-of-the-pineal-region-ptpr-two-cases-report-and-review-of-the-literature
#12
Cecilia Fernández-Mateos, Roberto Martinez, Jesús Vaquero
Tumours of the pineal region are rare in adulthood, accounting for approximately 1% of intracranial neoplasms in this age range. Because of their rarity, it has proven to be difficult to establish the optimal therapy. Furthermore, microsurgical total resection in this eloquent location is associated with not low rates of morbidity. We described two patients diagnosed of papillary tumours of the pineal region (PTPR) by stereotactic biopsy and referred for gamma knife radiosurgery after shunting for hydrocephalus...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29787612/psychosocial-needs-of-young-breast-cancer-survivors-in-mexico-city-mexico
#13
Harper G Hubbeling, Shoshana M Rosenberg, Maria Cecilia González-Robledo, Julia G Cohn, Cynthia Villarreal-Garza, Ann H Partridge, Felicia M Knaul
OBJECTIVE: Young breast cancer survivors in Mexico face distinct psychosocial challenges that have not been characterized. This study aims to describe the psychosocial needs of young breast cancer survivors in Mexico at 5 or more years of survivorship, identifying areas of focus for early interventions. METHODS: Breast cancer patients diagnosed at age 40 or prior with 5 or more years since diagnosis were invited to participate in one-on-one 30-60 minute semi-structured audio-recorded interviews at the Instituto Nacional de Cancerología in Mexico City...
2018: PloS One
https://www.readbyqxmd.com/read/29786960/the-atomic-resolution-structure-of-a-class-c-%C3%AE-lactamase-and-of-its-complex-with-avibactam
#14
Stefano Mangani, Cecilia Pozzi, Flavio Di Pisa, Filomena De Luca, Manuela Benvenuti, Jean-Denis Docquier
β-lactamases (BLs) are important antibiotic resistance determinants that significantly compromise the efficacy of valuable β-lactam antibacterial drugs. For that reason, combinations with β-lactamase inhibitor were developed. Avibactam is the first non-β-lactam BL inhibitor introduced in clinical practice. Ceftazidime-avibactam represents one of the few last-resort antibiotics available for the treatment of infections caused by near pandrug-resistant bacteria. TRU-1 is a chromosomally-encoded AmpC-type BL of Aeromonas enteropelogenes, related to the FOX-type BLs and constitutes a good model for class C BLs...
May 22, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29786849/isolation-and-characterization-of-wheat-derived-nonspecific-lipid-transfer-protein-2-nsltp2
#15
Sara Bosi, Jessica Fiori, Giovanni Dinelli, Neil Rigby, Emanuela Leoncini, Cecilia Prata, Valeria Bregola, Ilaria Marotti, Roberto Gotti, Marina Naldi, Luca Massaccesi, Marco Malaguti, Paul Kroon, Silvana Hrelia
Numerous studies support the protective role of bioactive peptides against cardiovascular diseases. Cereals represent the primary source of carbohydrates, but they also contain substantial amounts of proteins, therefore representing a potential dietary source of bioactive peptides with nutraceutical activities. The analysis of wheat extracts purified by chromatographic techniques by means of HPLC-UV/nanoLC-nanoESI-QTOF allowed the identification of a signal of about 7 kDa which, following data base searches, was ascribed to a nonspecific lipid-transfer protein (nsLTP) type 2 from Triticum aestivum (sequence coverage of 92%)...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29785836/facing-death-alone-or-together-investigating-the-interdependence-of-death-anxiety-dysfunctional-attitudes-and-quality-of-life-in-patient-caregiver-dyads-confronting-lung-cancer
#16
Bobo Hi-Po Lau, Daniel F K Wong, Y L Fung, Jillian Zhou, Cecilia L W Chan, Amy Y M Chow
BACKGROUND: Based on the cognitive theory, anxiety arising from the awareness of death and dying may activate dysfunctional attitudes, which may then reduce quality of life. This study examined the interdependence and the mediating role of dysfunctional attitudes on the relationship between death anxiety and quality of life among patients with lung cancer and their caregivers. METHODS: From March 2016 to April 2017, 173 pairs of patients and their caregivers enrolled in a randomized controlled trial of psychosocial support...
May 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29785352/diversity-and-community-structure-of-marine-microbes-around-the-benham-rise-underwater-plateau-northeastern-philippines
#17
Andrian P Gajigan, Aletta T Yñiguez, Cesar L Villanoy, Maria Lourdes San Diego-McGlone, Gil S Jacinto, Cecilia Conaco
Microbes are central to the structuring and functioning of marine ecosystems. Given the remarkable diversity of the ocean microbiome, uncovering marine microbial taxa remains a fundamental challenge in microbial ecology. However, there has been little effort, thus far, to describe the diversity of marine microorganisms in the region of high marine biodiversity around the Philippines. Here, we present data on the taxonomic diversity of bacteria and archaea in Benham Rise, Philippines, Western Pacific Ocean, using 16S V4 rRNA gene sequencing...
2018: PeerJ
https://www.readbyqxmd.com/read/29784875/a-human-specific-truncated-%C3%AE-7-nicotinic-receptor-subunit-assembles-with-full-length-%C3%AE-7-and-forms-functional-receptors-with-different-stoichiometries
#18
Matías Lasala, Jeremías Corradi, Ariana Bruzzone, María Del Carmen Esandi, Cecilia Bouzat
The cholinergic α7 nicotinic receptor gene, CHRNA7, encodes a subunit that forms the homopentameric α7 receptor, involved in learning and memory. In humans, exons 5-10 in CHRNA7 are duplicated and fused to the FAM7A genetic element, giving rise to the hybrid gene CHRFAM7A. Its product, dupα7, is a truncated subunit lacking part of the N-terminal extracellular ligand-binding domain and is associated with neurological disorders, including schizophrenia, and immunomodulation.We combined dupα7 expression on mammalian cells with patch clamp recordings to understand its functional role...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29784434/cell-therapy-with-autologous-mesenchymal-stromal-cells-in-post-traumatic-syringomyelia
#19
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Concepcion Aguayo, Cecilia Fernandez, Gregorio Rodriguez-Boto, Esperanza Marin, Noemi Tapiador, Marta Sevilla, Joaquin Carballido, David Vazquez, Damian Garcia-Olmo, Hector Guadalajara, Miguel Leon, Ignacio Valverde
BACKGROUND AIMS: Recently, clinical studies show that cell therapy with mesenchymal stromal cells (MSCs) improves the sequelae chronically established in paraplegic patients, being necessary to know which of them can obtain better benefit. METHODS: We present here a phase 2 clinical trial that includes six paraplegic patients with post-traumatic syringomyelia who received 300 million MSCs inside the syrinx and who were followed up for 6 months. Clinical scales, urodynamic, neurophysiological, magnetic resonance (MR) and studies of ano-rectal manometry were performed to assess possible improvements...
May 18, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29784426/financial-validation-of-the-european-society-of-thoracic-surgeons-risk-score-predicting-prolonged-air-leak-after-video-assisted-thoracic-surgery-lobectomy
#20
Alessandro Brunelli, Cecilia Pompili, Padma Dinesh, Vinod Bassi, Andrea Imperatori
OBJECTIVES: The objective of this study was to verify whether the European Society of Thoracic Surgeons prolonged air leak risk score for video-assisted thoracoscopic lobectomy was associated with incremental postoperative costs. METHODS: We retrospectively analyzed 353 patients subjected to video-assisted thoracoscopic lobectomy or segmentectomy (April 2014 to March 2016). Postoperative costs were obtained from the hospital Finance Department. Patients were grouped in different classes of risk according to their prolonged air leak risk score...
April 27, 2018: Journal of Thoracic and Cardiovascular Surgery
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