keyword
MENU ▼
Read by QxMD icon Read
search

cecilia

keyword
https://www.readbyqxmd.com/read/28092665/antibody-10-1074-suppresses-viremia-in-hiv-1-infected-individuals
#1
Marina Caskey, Till Schoofs, Henning Gruell, Allison Settler, Theodora Karagounis, Edward F Kreider, Ben Murrell, Nico Pfeifer, Lilian Nogueira, Thiago Y Oliveira, Gerald H Learn, Yehuda Z Cohen, Clara Lehmann, Daniel Gillor, Irina Shimeliovich, Cecilia Unson-O'Brien, Daniela Weiland, Alexander Robles, Tim Kümmerle, Christoph Wyen, Rebeka Levin, Maggi Witmer-Pack, Kemal Eren, Caroline Ignacio, Szilard Kiss, Anthony P West, Hugo Mouquet, Barry S Zingman, Roy M Gulick, Tibor Keler, Pamela J Bjorkman, Michael S Seaman, Beatrice H Hahn, Gerd Fätkenheuer, Sarah J Schlesinger, Michel C Nussenzweig, Florian Klein
Monoclonal antibody 10-1074 targets the V3 glycan supersite on the HIV-1 envelope (Env) protein. It is among the most potent anti-HIV-1 neutralizing antibodies isolated so far. Here we report on its safety and activity in 33 individuals who received a single intravenous infusion of the antibody. 10-1074 was well tolerated and had a half-life of 24.0 d in participants without HIV-1 infection and 12.8 d in individuals with HIV-1 infection. Thirteen individuals with viremia received the highest dose of 30 mg/kg 10-1074...
January 16, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28092420/immune-modulation-by-the-hepatitis-c-virus-core-protein
#2
Cecilia Fernández-Ponce, Juan Pedro Muñoz-Miranda, Mikel M Arbulo-Echevarria, Rocío Litrán, Enrique Aguado, Francisco García-Cozar
Hepatitis C virus (HCV) infection is currently the most important cause of chronic viral hepatitis in the world and one of the most frequent indications for liver transplantation. HCV uses different strategies to evade the innate and adaptive immune response, and this evasion plays a key role in determining viral persistence. Several HCV viral proteins have been described as immune modulators. In this review, we will focus on the effect of HCV nucleocapsid core protein in the function of immune cells and its correlation with the findings observed in HCV chronically infected patients...
January 16, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28092414/dce-mri-of-the-prostate-using-shutter-speed-vs-tofts-model-for-tumor-characterization-and-assessment-of-aggressiveness
#3
Stefanie J Hectors, Cecilia Besa, Mathilde Wagner, Guido H Jajamovich, George K Haines, Sara Lewis, Ashutosh Tewari, Ardeshir Rastinehad, Wei Huang, Bachir Taouli
PURPOSE: To quantify Tofts model (TM) and shutter-speed model (SSM) perfusion parameters in prostate cancer (PCa) and noncancerous peripheral zone (PZ) and to compare the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to Prostate Imaging and Reporting and Data System (PI-RADS) classification for the assessment of PCa aggressiveness. MATERIALS AND METHODS: Fifty PCa patients (mean age 60 years old) who underwent MRI at 3...
January 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28091362/epicutaneous-immunotherapy-for-the-treatment-of-peanut-allergy-in-children-and-young-adults
#4
Stacie M Jones, Scott H Sicherer, A Wesley Burks, Donald Y M Leung, Robert W Lindblad, Peter Dawson, Alice K Henning, M Cecilia Berin, David Chiang, Brian P Vickery, Robbie D Pesek, Christine B Cho, Wendy F Davidson, Marshall Plaut, Hugh A Sampson, Robert A Wood
BACKGROUND: Peanut allergy is common, life-threatening, and without therapeutic options. We evaluated peanut epicutaneous immunotherapy (EPIT) by using Viaskin Peanut for peanut allergy treatment. OBJECTIVE: We sought to evaluate the clinical, safety, and immunologic effects of EPIT for the treatment of peanut allergy. METHODS: In this multicenter, double-blind, randomized, placebo-controlled study, 74 participants with peanut allergy (ages 4-25 years) were treated with placebo (n = 25), Viaskin Peanut 100 μg (VP100; n = 24) or Viaskin Peanut 250 μg (VP250; n = 25; DBV Technologies, Montrouge, France)...
October 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28090664/development-of-a-novel-dual-cd-mekc-system-for-the-systematic-flavonoid-fingerprinting-of-ligaria-cuneifolia-r-et-p-tiegh-loranthaceae-extracts
#5
Cecilia B Dobrecky, Sabrina A Flor, Paula G López, Marcelo L Wagner, Silvia E Lucangioli
The present work deals with the development and validation of a novel dual CD-MEKC system for the systematic flavonoid fingerprinting of Ligaria cuneifolia (R. et P.) Tiegh. -Loranthaceae- extracts. The BGE consisted of 20 mM pH 8.3 borate buffer, 50 mM SDS, a dual CD system based on the combination of 5 mM β-CD and 2% w/v S-β-CD, and 10% v/v methanol. The proposed method has been successfully applied to the comparative analysis of extracts from aerial parts and different hosts, geographical areas and extraction procedures in order to establish the flavonoid fingerprint of L...
January 16, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28090115/report-of-the-2015-2016-academic-affairs-standing-committee
#6
Stuart T Haines, Brenda L Gleason, Alexander Kantorovich, Marianne McCollum, Amy L Pittenger, Cecilia M Plaza, Scott K Stolte, Jennifer M Trujillo
No abstract text is available yet for this article.
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28089973/malignancies-in-patients-with-anti-rna-polymerase-iii-antibodies-and-systemic-sclerosis-analysis-of-the-eular-scleroderma-trials-and-research-cohort-and-possible-recommendations-for-screening
#7
Maria-Grazia Lazzaroni, Ilaria Cavazzana, Enrico Colombo, Rucsandra Dobrota, Jasmin Hernandez, Roger Hesselstrand, Cecilia Varju, Gabriella Nagy, Vanessa Smith, Paola Caramaschi, Valeria Riccieri, Eric Hachulla, Alexandra Balbir-Gurman, Emmanuel Chatelus, Katarzyna Romanowska-Próchnicka, Ana Carolina Araújo, Oliver Distler, Yannick Allanore, Paolo Airò
OBJECTIVE: To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients. METHODS: (1) Analysis of the EUSTAR database: 4986 patients with information on their anti-RNAP3 status were included...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089646/a-risk-score-to-predict-the-incidence-of-prolonged-air-leak-after-video-assisted-thoracoscopic-lobectomy-an-analysis-from-the-european-society-of-thoracic-surgeons-database
#8
Cecilia Pompili, Pierre Emmanuel Falcoz, Michele Salati, Zalan Szanto, Alessandro Brunelli
OBJECTIVE: The study objective was to develop an aggregate risk score for predicting the occurrence of prolonged air leak after video-assisted thoracoscopic lobectomy from patients registered in the European Society of Thoracic Surgeons database. METHODS: A total of 5069 patients who underwent video-assisted thoracoscopic lobectomy (July 2007 to August 2015) were analyzed. Exclusion criteria included sublobar resections or pneumonectomies, lung resection associated with chest wall or diaphragm resections, sleeve resections, and need for postoperative assisted mechanical ventilation...
December 22, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28089535/farmer-attitudes-and-perceptions-to-the-re-use-of-fertiliser-products-from-resource-oriented-sanitation-systems-the-case-of-vellore-south-india
#9
Prithvi Simha, Cecilia Lalander, Björn Vinnerås, M Ganesapillai
Relatively little research has been conducted to date on farmer attitudes towards the use of fertilisers from resource-oriented sanitation systems. This study employed a psycho-sociological approach to identify factors that encourage, or discourage, negative and positive attitudes to human waste recycling among farmers in southern India. A survey involving face-to-face interviews was performed with 120 randomly sampled farmers, taking into account the following factors: gender, age, religion, caste, type of farming, farm size, annual income and farming history...
January 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28089216/diabetes-is-associated-with-severe-adverse-events-in-multidrug-resistant-tuberculosis
#10
Marcela Muñoz-Torrico, José Caminero-Luna, Giovanni Battista Migliori, Lia D'Ambrosio, José Luis Carrillo-Alduenda, Héctor Villareal-Velarde, Alfredo Torres-Cruz, Héctor Flores-Vergara, Dina Martínez-Mendoza, Cecilia García-Sancho, Rosella Centis, Miguel Ángel Salazar-Lezama, Rogelio Pérez-Padilla
INTRODUCTION: Diabetes mellitus (DM), a very common disease in Mexico, is a well-known risk factor for tuberculosis (TB). However, it is not known by which extent DM predisposes to adverse events (AE) to anti-TB drugs and/or to worse outcomes in patients with multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). The main objective of this study was to describe the outcomes of TB treatment, the impact of DM and the prevalence of AE in a cohort of patients with MDR-/XDR pulmonary TB treated at the national TB referral centre in Mexico City...
January 11, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28089079/repeated-subarachnoid-administrations-of-autologous-mesenchymal-stromal-cells-supported-in-autologous-plasma-improve-quality-of-life-in-patients-suffering-incomplete-spinal-cord-injury
#11
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Celia Bonilla, Concepción Aguayo, Cecilia Fernández, Noemí Tapiador, Marta Sevilla, Carlos Morejón, Jesús Montilla, Francisco Martínez, Esperanza Marín, Salvador Bustamante, David Vázquez, Joaquín Carballido, Alicia Rodríguez, Paula Martínez, Coral García, Mercedes Ovejero, Marta V Fernández
BACKGROUND AIMS: Cell therapy with mesenchymal stromal cells (MSCs) offers new hope for patients suffering from spinal cord injury (SCI). METHODS: Ten patients with established incomplete SCI received four subarachnoid administrations of 30 × 10(6) autologous bone marrow MSCs, supported in autologous plasma, at months 1, 4, 7 and 10 of the study, and were followed until the month 12. Urodynamic, neurophysiological and neuroimaging studies were performed at months 6 and 12, and compared with basal studies...
January 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28088873/developmental-changes-in-ultradian-sleep-cycles-across-early-childhood
#12
Sean Lopp, William Navidi, Peter Achermann, Monique LeBourgeois, Cecilia Diniz Behn
Nocturnal human sleep is composed of cycles between rapid eye movement (REM) sleep and non-REM (NREM) sleep. In adults, the structure of ultradian cycles between NREM and REM sleep is well characterized; however, less is known about the developmental trajectories of ultradian sleep cycles across early childhood. Cross-sectional studies indicate that the rapid ultradian cycling of active-quiet sleep in infancy shifts to a more adult-like pattern of NREM-REM sleep cycling by the school-age years, yet longitudinal studies elucidating the details of this transition are scarce...
January 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28088236/economic-burden-of-family-caregiving-for-elderly-population-in-southern-ghana-the-case-of-a-peri-urban-district
#13
Stephen Tettey Nortey, Genevieve Cecilia Aryeetey, Moses Aikins, Djesika Amendah, Justice Nonvignon
BACKGROUND: Health systems in low and lower-middle income countries, particularly in sub-Sahara Africa, often lack the specialized personnel and infrastructure to provide comprehensive care for elderly/ageing populations. Close-to-client community-based approaches are a low-cost way of providing basic care and social support for elderly populations in such resource-constrained settings and family caregivers play a crucial role in that regard. However, family caregiving duties are often unremunerated and their care-related economic burden is often overlooked though this knowledge is important in designing or scaling up effective interventions...
January 14, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28087941/interplay-between-myeloid-cells-and-humoral-innate-immunity
#14
Sébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, Alberto Mantovani
The innate immune system represents the first line of defense against pathogens and comprises both a cellular and a humoral arm. Fluid-phase pattern recognition molecules (PRMs), which include collectins, ficolins, and pentraxins, are key components of the humoral arm of innate immunity and are expressed by a variety of cells, including myeloid, epithelial, and endothelial cells, mainly in response to infectious and inflammatory conditions. Soluble PRMs share basic multifunctional properties including activation and regulation of the complement cascade, opsonization of pathogens and apoptotic cells, regulation of leukocyte extravasation, and fine-tuning of inflammation...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28087148/immunogenicity-differences-of-a-15-valent-pneumococcal-polysaccharide-conjugate-vaccine-pcv15-based-on-vaccine-dose-route-of-immunization-and-mouse-strain
#15
REVIEW
Ivette Caro-Aguilar, Lani Indrawati, Robin M Kaufhold, Christine Gaunt, Yuhua Zhang, Denise K Nawrocki, Cecilia Giovarelli, Michael A Winters, William J Smith, Jon Heinrichs, Julie M Skinner
Pneumococcal disease continues to be a medical need even with very effective vaccines on the market. Globally, there are extensive research efforts to improve serotype coverage with novel vaccines; therefore, conducting preclinical studies in different animal models becomes essential. The work presented herein focuses on evaluating a 15-valent pneumococcal conjugate vaccine (PCV15) in mice. Initially we evaluated several doses of PCV15 in Balb/c mice. The optimal vaccine dose was determined to be 0.4μg per pneumococcal polysaccharide (PS) (0...
January 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28081548/serum-ldh-predicts-benefit-from-bevacizumab-beyond-progression-in-metastatic-colorectal-cancer
#16
Federica Marmorino, Lisa Salvatore, Cecilia Barbara, Giacomo Allegrini, Lorenzo Antonuzzo, Gianluca Masi, Fotios Loupakis, Beatrice Borelli, Silvana Chiara, Maria Chiara Banzi, Emanuela Miraglio, Domenico Amoroso, Francesco Dargenio, Andrea Bonetti, Angelo Martignetti, Myriam Paris, Daniela Tomcikova, Luca Boni, Alfredo Falcone, Chiara Cremolini
BACKGROUND: Different antiangiogenics are currently indicated in the second-line treatment of metastatic colorectal cancer (mCRC), following a first-line bevacizumab-containing treatment. The magnitude of benefit is limited, but no predictors of benefit have been identified. METHODS: A total of 184 mCRC patients progressing to a first-line bevacizumab-containing treatment were randomised in the BEBYP study to continue or not the antiangiogenic in combination with a second-line chemotherapy...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28081239/statistical-modeling-applied-to-deformation-relaxation-processes-in-a-composite-biopolymer-network-induced-by-magnetic-field
#17
Javier Tarrío-Saavedra, Cécilia Galindo González, Salvador Naya, Jorge López-Beceiro, Alain Ponton
This study investigated a methodology based on image processing and statistics to characterize and model the deformation upon controlled and uniform magnetic field and the relaxation under zero field of droplets observed in aqueous solutions of sodium alginate incorporating magnetic maghemite nanoparticles stabilized by adsorption of citrate ions. The changes of droplet geometry were statistically analyzed using a new approach based on the data obtained from optical microscopy, image processing, nonlinear regression, evolutionary optimization, analysis of variance and resampling...
2017: PloS One
https://www.readbyqxmd.com/read/28081174/definition-of-human-epitopes-recognized-in-tetanus-toxoid-and-development-of-an-assay-strategy-to-detect-ex-vivo-tetanus-cd4-t-cell-responses
#18
Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S Lindestam Arlehamn
Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of those derived from prediction of HLA Class II binding. Forty-seven epitopes were identified following in vitro TT stimulation, with 28 epitopes accounting for 90% of the total response. Despite this diverse range of epitopes, individual responses were associated with only a few immunodominant epitopes, with each donor responding on average to 3 epitopes...
2017: PloS One
https://www.readbyqxmd.com/read/28077583/a-live-attenuated-chimeric-west-nile-virus-vaccine-rwn-den4%C3%AE-30-is-well-tolerated-and-immunogenic-in-flavivirus-naive-older-adult-volunteers
#19
Kristen K Pierce, Stephen S Whitehead, Beth D Kirkpatrick, Palmtama L Grier, Adrienne Jarvis, Heather Kenney, Marya P Carmolli, Cynthia Reynolds, Cecilia M Tibery, Janece Lovchik, Anna Janiak, Catherine J Luke, Anna P Durbin, Alexander G Pletnev
West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28077158/ccl2-driven-inflammation-increases-mammary-gland-stromal-density-and-cancer-susceptibility-in-a-transgenic-mouse-model
#20
Xuan Sun, Danielle J Glynn, Leigh J Hodson, Cecilia Huo, Kara Britt, Erik W Thompson, Lucy Woolford, Andreas Evdokiou, Jeffrey W Pollard, Sarah A Robertson, Wendy V Ingman
BACKGROUND: Macrophages play diverse roles in mammary gland development and breast cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits macrophages to sites of injury. Although CCL2 has been detected in human and mouse mammary epithelium, its role in regulating mammary gland development and cancer risk has not been explored. METHODS: Transgenic mice were generated wherein CCL2 is driven by the mammary epithelial cell-specific mouse mammary tumour virus 206 (MMTV) promoter...
January 11, 2017: Breast Cancer Research: BCR
keyword
keyword
48028
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"