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Amisulpride

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https://www.readbyqxmd.com/read/28096874/prevalence-of-metabolic-syndrome-in-patients-with-schizophrenia-in-korea-a-multicenter-nationwide-cross-sectional-study
#1
Jung Sun Lee, Jun Soo Kwon, Daeho Kim, Sung-Wan Kim, Jae-Jin Kim, Jong-Hoon Kim, Hee Jung Nam, Seunghyong Ryu, Il Ho Park, Suk Kyoon An, Hong-Seok Oh, Seunghee Won, Kanguk Lee, Kyu Young Lee, Seung-Hwan Lee, Yu Sang Lee, Jung-Seo Yi, Kyung Sue Hong, Yeon Ho Joo
OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28069917/dopamine-modulates-the-functional-organization-of-the-orbitofrontal-cortex
#2
Thorsten Kahnt, Philippe N Tobler
: Neuromodulators such as dopamine can alter the intrinsic firing properties of neurons, and may thereby change the configuration of larger functional circuits. The primate orbitofrontal cortex (OFC) receives dopaminergic input from midbrain nuclei, but the role of dopamine in the OFC is still unclear. Here we tested the idea that dopaminergic activity changes the pattern of connectivity between the OFC and the rest of the brain, and thereby reconfigures functional networks in the OFC...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28054367/development-of-an-uplc-ms-ms-method-for-routine-therapeutic-drug-monitoring-of-aripiprazole-amisulpride-olanzapine-paliperidone-and-ziprasidone-with-a-discussion-of-their-therapeutic-reference-ranges-for-chinese-patients
#3
Shao-Ting Wang, Yan Li
A highly feasible and reliable ultra-high performance liquid chromatography tandem mass spectrometry method was presented for therapeutic drug monitoring of five anti-schizophrenic drugs (amisulpride, olanzapine, aripiprazole, paliperidone and ziprasidone) simultaneously. To meet the requirements of practical clinical usage (easy-handling, high-throughput and cost effective), the pretreatment process has been especially simplified (only including protein precipitation and mobile phase dilution steps) and the UPLC separation cycle was set within 6 minutes...
January 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27977467/time-to-discontinuation-of-second-generation-antipsychotics-versus-haloperidol-and-sulpiride-in-people-with-schizophrenia-a-naturalistic-comparative-study
#4
Hung-Yu Chan, Yi-Ju Pan, Jiahn-Jyh Chen, Chiung-Hsu Chen
PURPOSE: A retrospective study was conducted to evaluate the time to discontinuation (TTD) of the first- (FGAs) and second-generation antipsychotics (SGAs). METHODS: In total, 918 treatment episodes of patients with schizophrenia, initiated on one of the investigated drugs on an outpatient basis during 2004-2006, were entered into the study. The primary outcome was the duration of the investigated treatment episode. Discontinuation was defined when either patients were admitted or the investigated drug had been stopped for more than 28 days...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27972884/comparative-evaluation-of-safety-efficacy-and-cognitive-profile-of-amisulpride-and-olanzapine-in-schizophrenia-patients-a-prospective-study
#5
S Ramesh, P Sivakumar, C Prashant, M Sivasankar, C Manikandhan, K P Jai Ganesh
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27903552/application-of-an-untargeted-chemometric-strategy-in-the-impurity-profiling-of-pharmaceuticals-an-example-of-amisulpride
#6
Robert Skibiński, Jakub Trawiński
The untargeted chemometric methodology for the impurity profiling of amisulpride pharmaceutical formulations was successfully applied and developed. For this purpose a fast, accurate and specific analytical method was elaborated with the use of ultra high pressure liquid chromatography coupled with high resolution hybrid electrospray ionization quadrupole time of flight mass spectrometer in a fast polarity switching mode. All the obtained chromatographic profiles were aligned and a multivariate chemometric analysis including principal component analysis and partial least square (PLS) was performed...
November 29, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27902493/intravenous-amisulpride-for-the-prevention-of-postoperative-nausea-and-vomiting-two-concurrent-randomized-double-blind-placebo-controlled-trials
#7
Tong J Gan, Peter Kranke, Harold S Minkowitz, Sergio D Bergese, Johann Motsch, Leopold Eberhart, David G Leiman, Timothy I Melson, Dominique Chassard, Anthony L Kovac, Keith A Candiotti, Gabriel Fox, Pierre Diemunsch
BACKGROUND: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. METHODS: Adult inpatients undergoing elective surgery during general anesthesia and having at least two of the four Apfel risk factors for postoperative nausea and vomiting were enrolled at 9 U...
February 2017: Anesthesiology
https://www.readbyqxmd.com/read/27900577/neuroleptic-drugs-and-pacap-differentially-affect-the-mrna-expression-of-genes-encoding-pac1-vpac-type-receptors
#8
Marta Jóźwiak-Bębenista, Edward Kowalczyk
Several lines of evidence suggest that pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide playing an important role as a neuromodulator. It has been indicated that PACAP is associated with mental diseases, and that regulation of the PACAPergic signals could be a potential target for the treatment of such psychiatric states as schizophrenia. Recent studies have suggested that action of neuroleptic drugs is mediated not only by dopaminergic and serotonergic neurotransmission, but also via neuropeptides which may act both as neurotransmitters and as neuromodulators...
November 30, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27877130/cannabidiol-as-a-potential-new-type-of-an-antipsychotic-a-critical-review-of-the-evidence
#9
REVIEW
Cathrin Rohleder, Juliane K Müller, Bettina Lange, F M Leweke
There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system has been suggested to represent a potential new target in this indication. While the chronic use of cannabis itself has been considered a risk factor contributing to the development of schizophrenia, triggered by the phytocannabinoid delta-9-tetrahydrocannabinol (Δ(9)-THC), cannabidiol, the second most important phytocannabinoid, appears to have no psychotomimetic potential...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27871032/level-of-serum-thioredoxin-and-correlation-with-neurocognitive-functions-in-patients-with-schizophrenia-using-clozapine-and-other-atypical-antipsychotics
#10
Alper Bas, Gozde Gultekin, Said Incir, Tuba Ocek Bas, Murat Emul, Alaatin Duran
Thioredoxin is a serum antioxidant that has been investigated in the etiology of schizophrenia. The aim of this study is investigating the relationship between serum thioredoxin levels and cognitive functions in acute psychotic episode and remission state patients with schizophrenia; and examining whether there were differences between patients using clozapine and other atypical antipsychotics; including risperidone, olanzapine and amisulpride. This research was performed in schizophrenia patients hospitalized with acute psychotic episode (n=57), reevaluated patients after the initiation of treatment (mean 16 weeks) (n=46), and healthy controls (n=41)...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27833237/extrapyramidal-side-effects-with-low-dose-amisulpride-a-report-of-two-cases
#11
Pattath Narayanan Suresh Kumar, Arun Gopalakrishnan
Amisulpride, recently introduced atypical antipsychotic, is well-known for its broad spectrum effectiveness and lower profile for extrapyramidal side effects (EPS). Its selective affinity for dopamine receptors in the limbic structures, but not in the striatum, leads to a low risk of extrapyramidal side effects. Here, we report two cases of EPS associated with lower dose of amisulpride. The proposed mechanism for its causation is also discussed. Authors invite more studies, specifically from the Indian context to find out the incidence of EPS and other associated side effects...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27794182/targeted-analysis-of-116-drugs-in-hair-by-uhplc-ms-ms-and-its-application-to-forensic-cases
#12
Xin Wang, Sys Stybe Johansen, Marie Katrine Klose Nielsen, Kristian Linnet
A multi-target method that can detect a broad range of drugs in human hair, such as hypnotics, anxiolytics, analgesics, benzodiazepines, antihistamines, antidepressants, antipsychotics, and anticonvulsants, was developed based on ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The drugs were extracted from 10 mg of washed hair by incubation for 18 h in a 25:25:50 (v/v/v) mixture of methanol/acetonitrile/2 mM ammonium formate (8% acetonitrile, pH 5.3). For 51% of the basic drugs, the lower limits of quantification (LLOQs) were in the range of 0...
October 29, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27776390/amisulpride-switching-in-schizophrenic-patients-who-showed-suboptimal-effect-and-or-tolerability-to-current-antipsychotics-in-a-naturalistic-setting-an-explorative-study
#13
Yongmin Kim, Sheng-Min Wang, Kyung-Phil Kwak, Ho-Kyoung Yoon, Chi-Un Pae, Jung-Jin Kim, Won-Myong Bahk
Objective: Despite numerous atypical antipsychotics (AAP) available, many patients with schizophrenia still experience lack of efficacy and persistent side-effects. Switching from one AAP to another with a different side-effect profile has become a common clinical strategy. We aimed to investigate effect of switching to amisulpride in patients who showed suboptimal effect and /or tolerability to current antipsychotics treatment. Methods: This was a 6-week, prospective, multicenter, open-label, flexible-dose study in patients with schizophrenia...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27771973/dopaminergic-enhancement-of-striatal-response-to-reward-in-major-depression
#14
Roee Admon, Roselinde H Kaiser, Daniel G Dillon, Miranda Beltzer, Franziska Goer, David P Olson, Gordana Vitaliano, Diego A Pizzagalli
OBJECTIVE: Major depressive disorder is characterized by reduced reward-related striatal activation and dysfunctional reward learning, putatively reflecting decreased dopaminergic signaling. The goal of this study was to test whether a pharmacological challenge designed to facilitate dopaminergic transmission can enhance striatal responses to reward and improve reward learning in depressed individuals. METHOD: In a double-blind placebo-controlled design, 46 unmedicated depressed participants and 43 healthy control participants were randomly assigned to receive either placebo or a single low dose (50 mg) of the D2/D3 receptor antagonist amisulpride, which is believed to increase dopamine signaling through presynaptic autoreceptor blockade...
October 24, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27764107/development-of-a-web-based-clinical-decision-support-system-for-drug-prescription-non-interventional-naturalistic-description-of-the-antipsychotic-prescription-patterns-in-4345-outpatients-and-future-applications
#15
Sofian Berrouiguet, Maria Luisa Barrigón, Sara A Brandt, Santiago Ovejero-García, Raquel Álvarez-García, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Enrique Baca-García
PURPOSE: The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS. METHOD: A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27663802/an-update-on-meta-analysis-of-medical-and-non-medicaltreatments-of-the-prodromal-phase-of-psychotic-illness-in-at-risk-mental-states
#16
Gavin Deas, Christopher Kelly, Andreas V Hadjinicolaou, Clare Holt, Mark Agius, Rashid Zaman
INTRODUCTION: There are now many existing studies which assess the treatments available for 'at risk mental states', as patients who are believed to be in the prodromal phase of psychotic illness are referred to. However, concerns regarding side effects of possible treatments remain. We here conduct a meta-analysis of the studies available up to July 2016. The aim of this study is to decide what would be the best treatment for 'at high risk patients'. RESULTS: 18 studies were selected for inclusion; 12 showed significance, 5 did not and one tended towards significance...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27618796/thorough-qt-study-of-the-effect-of-intravenous-amisulpride-on-qtc-interval-in-caucasian-and-japanese-healthy-subjects
#17
Jörg Täubel, Georg Ferber, Gabriel Fox, Sara Fernandes, Ulrike Lorch, A John Camm
AIM: The D2 /D3 antagonist amisulpride has shown promising efficacy against postoperative nausea and vomiting (PONV) at low doses. We investigated whether intravenous amisulpride has an effect on the QTc interval in a formal Thorough QT study (TQT). METHODS: This was a randomized, double-blind, placebo and positive-controlled, four-way crossover study. Forty healthy Caucasian and Japanese subjects were included to receive a single administration of 5 mg and 40 mg of i...
September 12, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27617414/identifying-a-system-of-predominant-negative-symptoms-network-analysis-of-three-randomized-clinical-trials
#18
Stephen Z Levine, Stefan Leucht
BACKGROUND: Reasons for the recent mixed success of research into negative symptoms may be informed by conceptualizing negative symptoms as a system that is identifiable from network analysis. We aimed to identify: (I) negative symptom systems; (I) central negative symptoms within each system; and (III) differences between the systems, based on network analysis of negative symptoms for baseline, endpoint and change. METHODS: Patients with chronic schizophrenia and predominant negative symptoms participated in three clinical trials that compared placebo and amisulpride to 60days (n=487)...
December 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27569526/multisite-prediction-of-4-week-and-52-week-treatment-outcomes-in-patients-with-first-episode-psychosis-a-machine-learning-approach
#19
Nikolaos Koutsouleris, René S Kahn, Adam M Chekroud, Stefan Leucht, Peter Falkai, Thomas Wobrock, Eske M Derks, Wolfgang W Fleischhacker, Alkomiet Hasan
BACKGROUND: At present, no tools exist to estimate objectively the risk of poor treatment outcomes in patients with first-episode psychosis. Such tools could improve treatment by informing clinical decision-making before the commencement of treatment. We tested whether such a tool could be successfully built and validated using routinely available, patient-reportable information. METHODS: By applying machine learning to data from 334 patients in the European First Episode Schizophrenia Trial (EUFEST; International Clinical Trials Registry Platform number, ISRCTN68736636), we developed a tool to predict poor versus good treatment outcome (Global Assessment of Functioning [GAF] score ≥65 vs GAF <65, respectively) after 4 weeks and 52 weeks of treatment...
October 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27553839/current-data-on-and-clinical-insights-into-the-treatment-of-first-episode-nonaffective-psychosis-a-comprehensive-review
#20
REVIEW
Benedicto Crespo-Facorro, Jose Maria Pelayo-Teran, Jacqueline Mayoral-van Son
Implementing the most suitable treatment strategies and making appropriate clinical decisions about individuals with a first episode of psychosis (FEP) is a complex and crucial task, with relevant impact in illness outcome. Treatment approaches in the early stages should go beyond choosing the right antipsychotic drug and should also address tractable factors influencing the risk of relapse. Effectiveness and likely metabolic and endocrine disturbances differ among second-generation antipsychotics (SGAs) and should guide the choice of the first-line treatment...
December 2016: Neurology and Therapy
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