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Attention Deficit Hyperactivity Disorder

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https://www.readbyqxmd.com/read/28527020/changes-in-serum-levels-of-kynurenine-metabolites-in-paediatric-patients-affected-by-adhd
#1
Melania Evangelisti, Pietro De Rossi, Jole Rabasco, Renato Donfrancesco, Luana Lionetto, Matilde Capi, Gabriele Sani, Maurizio Simmaco, Ferdinando Nicoletti, Maria Pia Villa
This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms that are pivotal in ADHD and thus potentially representing peripheral biomarkers of the disorder. We measured serum levels of tryptophan and some metabolites of the kynurenine pathway in 102 children with ADHD and 62 healthy controls by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
May 19, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28527018/predicting-academic-impairment-and-internalizing-psychopathology-using-a-multidimensional-framework-of-sluggish-cognitive-tempo-with-parent-and-adolescent-reports
#2
Zoe R Smith, Joshua M Langberg
Adolescents with Sluggish Cognitive Tempo (SCT) exhibit symptoms of slowness, mental confusion, excessive daydreaming, low motivation, and drowsiness/sleepiness. Although many symptoms of SCT reflect internalizing states, no study has evaluated the clinical utility of self-report of SCT in an attention-deficit/hyperactivity disorder (ADHD) sample. Furthermore, it remains unclear whether SCT is best conceptualized as a unidimensional or multidimensional construct. In a sample of 262 adolescents comprehensively diagnosed with ADHD, the present study used adolescent- and parent reports of SCT to evaluate the predictive utility of a general SCT factor from a bifactor modeling approach compared the utility of three specific SCT factors (slow, sleepy, and daydreamer) for predicting academic impairment and internalizing psychopathology...
May 19, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28524461/editorial-the-continuing-contributions-of-multimodal-treatment-of-attention-over-nearly-two-decades-to-initial-attention-deficit-hyperactivity-disorder-pharmacotherapy-and-long-term-clinical-course
#3
EDITORIAL
Michael H Bloch
The initial results of the Multimodal Treatment of Attention Deficit Hyperactivity Disorder (MTA) trial had profound effects on the way that Attention-Deficit Hyperactivity Disorder (ADHD) is managed clinically. Children from the original MTA cohort as well as a control group have been followed longitudinally for well over a decade and are beginning to provide important data regarding the long-term clinical course, treatment and consequences of ADHD into adulthood. Two articles in this issue of JCPP highlight important contributions from the MTA cohort...
June 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28523385/attention-deficit-hyperactivity-disorder-adhd-symptoms-in-children-adopted-from-poland-and-their-atypical-association-patterns-a-bayesian-approach
#4
Donna A de Maat, Sandra Knuiman, Catharina H A M Rijk, René A C Hoksbergen, Anneloes L van Baar
Although high rates of attention-deficit hyperactivity disorder (ADHD) symptoms have been observed among internationally adopted children, research on these symptoms in Polish adoptees is lacking. Therefore, we examined ADHD symptoms in Polish adoptees and their relationship to pre-adoptive risk factors, that is, time in institutional care, early deprivation, and prenatal alcohol exposure. We further compared the association patterns and gender distribution of ADHD symptoms in children adopted from Poland to those reported in the literature for ADHD symptoms in non-adopted children...
May 18, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28522087/mazindol-a-risk-factor-for-pulmonary-arterial-hypertension
#5
Eric Konofal, Cherine Benzouid, Christophe Delclaux, Michel Lecendreux, Elizabeth Hussey
Mazindol is an imidazo-isoindole derivative, a tricyclic compound and a non-amphetamine central nervous system stimulant that blocks dopamine and norepinephrine reuptake. Mazindol was withdrawn from the US and European markets in 1999 for reasons unrelated to its efficacy or safety around a time when other anorexic drugs were found to be associated with the development of pulmonary arterial hypertension (PAH). Despite the use of mazindol for decades, reports of PAH due to mazindol intake have been extremely rare...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521251/the-protective-effect-of-character-maturity-in-child-aggressive-antisocial-behavior
#6
Nóra Kerekes, Örjan Falk, Sven Brändström, Henrik Anckarsäter, Maria Råstam, Björn Hofvander
BACKGROUND: Childhood aggressive antisocial behavior (CD) is one of the strongest predictors of mental health problems and criminal behavior in adulthood. The aims of this study were to describe personality profiles in children with CD, and to determine the strength of association between defined neurodevelopmental symptoms, dimensions of character maturity and CD. METHODS: A sample of 1886 children with a close to equal distribution of age (9 or 12) and gender, enriched for neurodevelopmental and psychiatric problems were selected from the nationwide Child and Adolescent Twin Study in Sweden...
April 29, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28521112/prevalence-of-externalizing-disorders-and-autism-spectrum-disorder-among-children-with-fetal-alcohol-spectrum-disorder-systematic-review-and-meta-analysis
#7
Shannon Lange, Jürgen Rehm, Evdokia Anagnostou, Svetlana Popova
Due to their central nervous system impairments, children with Fetal Alcohol Spectrum Disorder (FASD) commonly exhibit externalizing behaviours such as hyperactivity, impulsivity, and/or delinquency. The purpose of the current study was to estimate the prevalence of neurodevelopmental disorders with prominent externalizing behaviours, namely Attention-Deficit Hyperactivity Disorder (ADHD), Conduct Disorder (CD), Oppositional Defiant Disorder (ODD), as well as Autism Spectrum Disorder (ASD) among children with FASD...
May 18, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28520552/prestimulus-inhibition-of-saccades-in-adults-with-and-without-attention-deficit-hyperactivity-disorder-as-an-index-of-temporal-expectations
#8
Yarden Dankner, Lilach Shalev, Marisa Carrasco, Shlomit Yuval-Greenberg
Knowing when to expect important events to occur is critical for preparing context-appropriate behavior. However, anticipation is inherently complicated to assess because conventional measurements of behavior, such as accuracy and reaction time, are available only after the predicted event has occurred. Anticipatory processes, which occur prior to target onset, are typically measured only retrospectively by these methods. In this study, we utilized a novel approach for assessing temporal expectations through the dynamics of prestimulus saccades...
May 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28513190/prevalence-and-correlates-of-bullying-victimisation-and-perpetration-in-a-nationally-representative-sample-of-australian-youth
#9
Hannah J Thomas, Jason P Connor, David M Lawrence, Jennifer M Hafekost, Stephen R Zubrick, James G Scott
OBJECTIVE: Bullying prevalence studies are limited by varied measurement methods and a lack of representative samples. This study estimated the national prevalence of bullying victimisation, perpetration and combined victim-perpetration experiences in a representative population-based sample of Australian youth. The relationships between the three types of bullying involvement with a range of mental health symptoms and diagnoses were also examined. METHODS: A randomly selected nationally representative sample aged 11-17 years ( N = 2967, Mage = 14...
May 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28511579/does-an-attention-bias-to-appetitive-and-aversive-words-modulate-interference-control-in-youth-with-adhd
#10
Ili Ma, Gabry W Mies, Nanda N J Lambregts-Rommelse, Jan K Buitelaar, Antonius H N Cillessen, Anouk Scheres
Interference control refers to the ability to selectively attend to certain information while ignoring distracting information. This ability can vary as a function of distractor relevance. Distractors that are particularly relevant to an individual may attract more attention than less relevant distractors. This is referred to as attention bias. Weak interference control and altered reward sensitivity are both important features of attention deficit hyperactivity disorder (ADHD). However, interference control is typically studied in isolation...
May 16, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28509968/sleep-problems-in-children-with-attention-deficit-hyperactivity-disorder-associations-with-parenting-style-and-sleep-hygiene
#11
Emma Sciberras, Jie Cheng Song, Melissa Mulraney, Tibor Schuster, Harriet Hiscock
We aimed to examine the association between sleep problems and parenting and sleep hygiene in children with attention-deficit/hyperactivity disorder (ADHD). Participants included 5-13-year-old children with DSM 5 defined ADHD and a parent-reported moderate-to-severe sleep problem (N = 361). Sleep was assessed using the parent-reported Children's Sleep Habits Questionnaire. Parents also completed checklists assessing sleep hygiene, parenting consistency, and parenting warmth. Linear regression established prediction models controlling for confounding variables including child age and sex, ADHD symptom severity, comorbidities, medication use, and socio-demographic factors...
May 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28509905/crowdsourced-validation-of-a-machine-learning-classification-system-for-autism-and-adhd
#12
M Duda, N Haber, J Daniels, D P Wall
Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) together affect >10% of the children in the United States, but considerable behavioral overlaps between the two disorders can often complicate differential diagnosis. Currently, there is no screening test designed to differentiate between the two disorders, and with waiting times from initial suspicion to diagnosis upwards of a year, methods to quickly and accurately assess risk for these and other developmental disorders are desperately needed...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28509853/predictors-of-caregiver-burden-among-mothers-of-children-with-chronic-conditions
#13
Karina Javalkar, Eniko Rak, Alexandra Phillips, Cara Haberman, Maria Ferris, Miranda Van Tilburg
OBJECTIVE: The complex medical regimens of children and adolescents with chronic conditions can have a significant impact on families and households. Caregivers may experience burden, which can lead to negative health consequences and poor quality of life. The objective of this study was to determine child-related predictors and risk factors for caregiver burden among parents of children with chronic conditions. METHODS: We distributed an institutional review board (IRB)-approved, online cross-sectional survey to parents of children who attended the Victory Junction therapeutic camp...
May 16, 2017: Children
https://www.readbyqxmd.com/read/28509573/adverse-events-of-atomoxetine-in-a-double-blind-placebo-controlled-study-in-children-with-autism
#14
Rameshwari V Tumuluru, Patricia Corbett-Dick, Michael G Aman, Tristram Smith, L Eugene Arnold, Xueliang Pan, Kristin A Buchan-Page, Nicole V Brown, Melissa M Ryan, Susan L Hyman, Jessica Hellings, Craig Williams, Jill A Hollway, Luc Lecavalier, Robert R Rice, Sarah McAuliffe-Bellin, Benjamin L Handen
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) symptoms, including inattention and over activity, occur in approximately one-third of children with autism spectrum disorder (ASD). We describe the rate and duration of adverse events in a randomized controlled trial of atomoxetine (ATX) and parent training (PT) for ADHD symptoms and noncompliance in children with ASD. METHODS: We conducted a 10-week, double-blind, 2 × 2 trial of ATX and PT with 128 children (ages 5-14) randomized to ATX alone, ATX+PT, placebo+PT, or placebo alone...
May 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28508302/handedness-and-attention-deficit-hyperactivity-disorder-symptoms-in-college-students
#15
Hui-Li Lin, Hui-Chun Tsuang
The symptoms of adult Attention Deficit/Hyperactivity Disorder (ADHD) generally include impaired concentration; an insensitivity to social cues, being hard to get along with, and being internally restlessness. It is not surprising that these problems are likely to affect the performance of college students with ADHD. The study aims to examine whether ADHD symptoms are associated with handedness in college students in Taiwan. A total of 505 male and 645 female participants completed Annett's handedness questionnaire and the Traditional Chinese College ADHD Response Evaluation Student Response Inventory (C-CARE-SRI)...
May 16, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28507595/differential-therapeutic-effects-of-atomoxetine-and-methylphenidate-in-childhood-attention-deficit-hyperactivity-disorder-as-measured-by-near-infrared-spectroscopy
#16
Yoko Nakanishi, Toyosaku Ota, Junzo Iida, Kazuhiko Yamamuro, Naoko Kishimoto, Kosuke Okazaki, Toshifumi Kishimoto
BACKGROUND: The stimulant methylphenidate (MPH) and the nonstimulant atomoxetine (ATX) are the most commonly-prescribed pharmacological treatments for attention deficit/hyperactivity disorder (ADHD). However, the drug-specific mechanism of action on brain function in ADHD patients is not well known. This study examined differences in prefrontal hemodynamic activity between MPH and ATX in children with ADHD as measured by near-infrared spectroscopy (NIRS) using the Stroop color-word task...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28507356/school-going-adolescents-perception-of-family-climate-and-mental-problems-results-from-kocaeli-turkey
#17
Safak Eray, Ayse Pinar Vural, Deniz Sigirli
OBJECTIVE: To investigate the association between the perception of expressed emotion and psychopathology of school-going adolescents in a non-clinical sample. METHODS: The cross-sectional field study was conducted in Kocaeli, Turkey, and comprised high-school students during the 2014-15 school years. Data was collected using the Information Collection Form, Strengths and Difficulties Questionnaire and Shortened Level of Expressed Emotion Scale. SPSS 21 was used for data analysis...
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28506622/meta-analyses-of-reln-variants-in-neuropsychiatric-disorders
#18
Na Chen, Yanping Bao, Yanxue Xue, Yan Sun, Die Hu, Shiqiu Meng, Lin Lu, Jie Shi
Reelin is a critical extracellular matrix glycoprotein and implicated in neurodevelopment and psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also been reported to be associated with several psychiatric disorders, but the results remain controversial. Here, we conducted meta-analyses of RELN gene SNPs and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, Alzheimer's disease and bipolar disorders). A total of 12 SNPs (rs736707, rs362691, rs607755, rs2229864, rs7341475, rs262355, rs362719, rs11496125, g...
May 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28506353/-effect-of-baicalin-on-atpase-and-ldh-and-its-regulatory-effect-on-the-ac-camp-pka-signaling-pathway-in-rats-with-attention-deficit-hyperactivity-disorder
#19
Rong-Yi Zhou, Jiao-Jiao Wang, Yue You, Ji-Chao Sun, Yu-Chen Song, Hai-Xia Yuan, Xin-Min Han
OBJECTIVE: To study the effect of baicalin on synaptosomal adenosine triphosphatase (ATPase) and lactate dehydrogenase (LDH) and its regulatory effect on the adenylate cyclase (AC)/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway in rats with attention deficit hyperactivity disorder (ADHD). METHODS: A total of 40 SHR rats were randomly divided into five groups: ADHD model, methylphenidate hydrochloride treatment (0.07 mg/mL), and low-dose (3...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28504561/sexual-violence-and-intimate-partner-violence-in-college-women-with-a-mental-health-and-or-behavior-disability
#20
Amy Bonomi, Emily Nichols, Rebecca Kammes, Troye Green
OBJECTIVES: We address questions about (1) how college women with a disability experience sexual violence (SV) and intimate partner violence (IPV) across partners, including disability-specific abuse and (2) how SV/IPV impacts psychological, behavioral, physical, and academic life domains. METHODS/DESIGN: Twenty-seven female college students (mean age, 21.2; 66.6% white; 66.6% heterosexual) were randomly sampled from university registrar records. To be eligible for the study, students had to have at least one experience of SV/IPV since age 18 and a disability (88...
May 15, 2017: Journal of Women's Health
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