keyword
MENU ▼
Read by QxMD icon Read
search

Coagulation & Hemostasis

keyword
https://www.readbyqxmd.com/read/28107762/thulium-laser-in-interventional-endoscopy-animal-and-human-studies
#1
Gian E Tontini, Helmut Neumann, Luca Pastorelli, Luisa Spina, Flaminia Cavallaro, Paola Soriani, Alessandro Rimondi, Barbara Bruni, Claudio Clemente, Filippo Fagnani, Pavlos Lagoussis, Luca Carmignani, Maurizio Vecchi
Background and study aims The thulium laser system (TLS) is an emerging surgical tool. The 2-μm wavelength provides a confined coagulation depth (0.2 - 0.4 mm) to reduce the potential for inadvertent injuries. For the first time ever, we assessed TLS feasibility for endoscopic hemostasis ex vivo in pigs. In addition, we performed the first in vivo hemostatic treatments in humans. Patients and methods Tissue damage induced by TLS using different settings and optical fibers was compared to that from argon plasma coagulation (APC) in established ex vivo animal models...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28102766/soluble-p-selectin-rescues-mice-from-anthrax-lethal-toxin-induced-mortality-through-psgl-1-pathway-mediated-correction-of-hemostasis
#2
Der-Shan Sun, Yao-Wen Chang, Jyh-Hwa Kau, Hsin-Hsien Huang, Pei-Hsun Ho, Yin-Jeh Tzeng, Hsin-Hou Chang
As one of the virulence factors of Bacillus anthracis, lethal toxin (LT) induces various pathogenic responses including the suppression of the coagulation system. In this study, we observed that LT markedly increased the circulating soluble P-selectin (sP-sel) levels and microparticle (MP) count in wild-type but not P-selectin (P-sel, Selp(-)(-)(-)) or P-sel ligand-1 (PSGL-1, Selplg(-)(-)(-)) knockout mice. Because sP-sel induces a hypercoagulable state through PSGL-1 pathway to generate tissue factor-positive MPs, we hypothesized that the increase in plasma sP-sel levels can be a self-rescue response in hosts against the LT-mediated suppression of the coagulation system...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28094486/understanding-developmental-hemostasis-through-the-use-of-viscoelastic-tests-of-whole-blood-coagulation
#3
David Faraoni, James D O'Leary
No abstract text is available yet for this article.
January 17, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28091900/antithrombotic-protective-effects-of-arg-pro-gly-pro-peptide-during-emotional-stress-provoked-by-forced-swimming-test-in-rats
#4
M E Grigor'eva, L A Lyapina
Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Administration of this peptide in 5 min after swimming test also enhanced anticoagulant, fibrinolytic, and antithrombotic activity of the blood. Therefore, glyproline Arg-Pro-Gly-Pro exerted both preventive and curative effects on the hemostasis system and prevented enhancement of blood coagulation provoked by emotional stress modeled by forced swimming test...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28081351/the-effect-of-methylprednisolone-treatment-on-fibrinolysis-thecoagulation-system-and-blood-loss-in-cardiac-surgery
#5
Leila Ebrahimi, Maryam Kheirandish, Mahnoosh Foroughi
BACKGROUND/AIM: The purpose of this study was to examine steroid pretreatment in order to decrease postoperative coagulopathy disorders and bleeding. MATERIALS AND METHODS: In this randomized double-blinded study, the efficacy of low versus high doses of methylprednisolone on the coagulation system and postoperative bleeding was compared in patients who were undergoing cardiac surgery with cardiopulmonary bypass (CPB). The platelet response to agonists, D-dimer concentration, tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1) antigens, and platelet receptors CD42b, CD62P, and CD41a were evaluated...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28078811/the-effects-of-nanomaterials-on-blood-coagulation-in-hemostasis-and-thrombosis
#6
REVIEW
Jan Simak, Silvia De Paoli
The blood coagulation balance in the organism is achieved by the interaction of the blood platelets (PLTs) with the plasma coagulation system (PCS) and the vascular endothelial cells. In healthy organism, these systems prevent thrombosis and, in events of vascular damage, enable blood clotting to stop bleeding. The dysregulation of hemostasis may cause serious thrombotic and/or hemorrhagic pathologies. Numerous engineered nanomaterials are being investigated for biomedical purposes and are unavoidably exposed to the blood...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28063764/plasma-transfusion-in-patients-with-cirrhosis-in-china-a-retrospective-multicenter-cohort-study
#7
REVIEW
Yao Lu, Guixiang Sun, Xiangfu Liu, Zhiguo Liu, Jianguo Tan, Yiwen Hao, Guiqiu Shan, Qun Luo, Deqing Wang, Yanchao Xing, Xianqing Zhang, Jiwu Gong, Simon J Stanworth, Jun Wang, Aiqing Wen
Patients with cirrhosis used to be associated with frequent use of blood components because of their complex disorder of hemostasis and bleeding complications. Recent findings have indicated that patients with cirrhosis have a state of "rebalanced" or even procoagulant hemostasis and have questioned the prophylactic use of plasma. To evaluate the current status of plasma use in patients with cirrhosis, we conducted a retrospective survey in 11 tertiary-care hospitals in China from September 1 to October 31, 2013...
December 2, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28062179/effects-of-non-focused-microbubble-enhanced-and-high-intensity-focused-ultrasound-on-hemostasis-in-a-rabbit-model-of-liver-trauma
#8
Da-Wei Zhao, Meng Tian, Jian-Zhong Zou, Yuan-Yi Zheng, Tao Li
Uncontrolled hemorrhage after trauma to the liver can lead to death. The present study compared the effects of non-focused microbubble-enhanced ultrasound and high-intensity focused ultrasound on hepatic hemostasis in the injured liver. Blood perfusion level, serum liver enzyme levels and the aspartate transaminase/alanine transaminase ratio differed between the two types of treatment (all p values < 0.05). Hepatic cells in the microbubble-enhanced ultrasound group exhibited edema and compressed the hepatic sinus and blood vessels in the portal area...
January 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28058213/face-transplantation-anesthetic-challenges
#9
REVIEW
Aparna Dalal
Face transplantation is a complex vascular composite allotransplantation (VCA) surgery. It involves multiple types of tissue, such as bone, muscles, blood vessels, nerves to be transferred from the donor to the recipient as one unit. VCAs were added to the definition of organs covered by the Organ Procurement and Transplantation Network Final Rule and National Organ Transplant Act. Prior to harvest of the face from the donor, a tracheostomy is usually performed. The osteotomies and dissection of the midface bony skeleton may involve severe hemorrhagic blood loss often requiring transfusion of blood products...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28057488/exploring-hemostatic-and-thrombolytic-potential-of-heynein-a-cysteine-protease-from-ervatamia-heyneana-latex
#10
Priyanka Uday, M Maheshwari, P Sharanappa, Zohara Nafeesa, Vivek Hamse Kameshwar, B S Priya, S Nanjunda Swamy
ETHNOPHARMACOLOGIAL RELEVANCE: The latex of Ervatamia heyneana (Wall.) T. Cooke plant has been used for wound healing and various skin diseases by Indian tribes and folklore. AIM OF THE STUDY: To validate the scientific basis of heynein - a key protease of Ervatamia heyneana, in hemostasis and wound healing process. MATERIALS AND METHODS: The latex from E. heyneana was processed and subjected to two step purification. The purified heynein was assayed for proteolytic activity using casein as substrate and also attested by zymography...
January 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28039188/abnormal-joint-and-bone-wound-healing-in-hemophilia-mice-is-improved-by-extending-factor-ix-activity-after-hemarthrosis
#11
Junjiang Sun, Baolai Hua, Eric W Livingston, Sarah Taves, Peter B Johansen, Maureane Hoffman, Mirella Ezban, Dougald M Monroe, Ted A Bateman, Paul E Monahan
Wound healing requires interactions between coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Healing in dermal wounds of hemophilia B mice is delayed when compared to hemostatically normal wild type (WT) mice, with abnormal persistence of iron deposition, inflammation, and neovascularity. We observed healing following induced joint hemorrhage in WT and factor IX (FIX) knockout (FIX(-/-)) mice, examining also parameters previously studied in an excisional skin wound model. Hemostatically normal mice tolerated this joint bleeding challenge, cleared blood from the joint, and healed with minimal pathology, even if additional autologous blood was injected intra-articularly at the time of wounding...
December 30, 2016: Blood
https://www.readbyqxmd.com/read/28017497/developmental-hemostasis-a-lifespan-from-neonates-and-pregnancy-to-the-young-and-elderly-adult-in-a-european-white-population
#12
Ulrike Nowak-Göttl, Verena Limperger, Gili Kenet, Frauke Degenhardt, Roman Arlt, Justus Domschikowski, Hartmut Clausnizer, Jürgen Liebsch, Ralf Junker, Dagmar Steppat
Absolute values of reference ranges for coagulation assays in humans vary within the entire lifespan and confirm the concept of developmental hemostasis. It is known that physiologic concentrations of coagulation factors (F) gradually increase over age: they are lower in premature infants as compared to full-term babies, healthy children or adults. Here we demonstrate in a cohort of 1011 blood donors and in a group of 193 healthy pregnant women, that the process of developmental hemostasis proceeds in adults...
December 5, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28011097/hemostasis-during-ovarian-cystectomy-a-systematic-review-of-the-impact-of-suturing-versus-surgical-energy-on-ovarian-function
#13
REVIEW
Ann Peters, Noah B Rindos, Ted Lee
This systematic review compares the effect of suturing and surgical energy utilized for hemostasis during ovarian cystectomies on ovarian function. A search of the Scopus, Embase, and PubMed databases was conducted through December 1(st) 2016 for prospective and retrospective trials as well as Randomized Controlled Trials (RCTs) that analyzed ovarian function following ovarian cystectomies where hemostasis was obtained using suturing vs. surgical energy. Of the twenty-five studies identified, twelve studies, with a total of 1,133 subjects, met the criteria and were included in this review...
December 21, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28007958/polyphosphate-and-rna-differentially-modulate-the-contact-pathway-of-blood-clotting
#14
Joshua M Gajsiewicz, Stephanie A Smith, James H Morrissey
The contact pathway of the plasma clotting cascade is dispensable for normal hemostasis, but contributes to thrombosis and serves as a bridge between inflammation and coagulation. This pathway is triggered upon exposure of plasma to certain anionic polymers and artificial surfaces. Recently, extracellular nucleic acids and inorganic polyphosphate (polyP) have been implicated as being important (patho)physiologically relevant activators of this pathway. However, mechanistic details regarding how nucleic acids or polyP modulate the individual reactions of the contact pathway have been lacking...
December 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28004432/role-of-coagulation-factors-in-urological-malignancy-a-prospective-controlled-study-on-prostate-renal-and-bladder-cancer
#15
Aristeidis Alevizopoulos, Stavros Tyritzis, Ioannis Leotsakos, Ioanna Anastasopoulou, Christos Pournaras, Paraskevi Kotsis, Olga Katsarou, Christos Alamanis, Konstantinos Stravodimos, Constantinos Constantinides
OBJECTIVES: To study the behavior of specific coagulation factors in different types of non-metastatic urological cancers, and to identify their possible role as diagnostic and prognostic markers. METHODS: This was a prospective controlled study, which included three cancer patient groups and a control group of healthy individuals. The cancer subgroups consisted of renal (n = 44), prostate (n = 56) and bladder cancer (n = 47). We excluded patients receiving anticoagulant therapy, or with significant comorbidity...
December 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27998147/chitosan-coated-diatom-silica-as-hemostatic-agent-for-hemorrhage-control
#16
Chao Feng, Jing Li, Guang Sheng Wu, Yu Zhi Mu, Ming Kong, Chang Qing Jiang, Xiao Jie Cheng, Ya Liu, Xi Guang Chen
Uncontrolled hemorrhage leads to high death risk both in military and civilian trauma. Current hemostatic agents still have various limitations and side effects. In this study, natural diatom silica obtained from diatomite and diatom culture was purified and developed for hemorrhage control. To improve the biocompatibility and hemostatic performance of diatom silica, a series of chitosan-coated diatom (CS-diatom) was developed. The composition of CS-diatom prepared was optimized by in vitro hemocompatibility and blood coagulation evaluation for that prepared with 0...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27978589/gene-variations-in-the-protein-c-and-fibrinolytic-pathway-relevance-for-severity-and-outcome-in-pediatric-sepsis
#17
Navin P Boeddha, Marieke Emonts, Marjon H Cnossen, Moniek P de Maat, Frank W Leebeek, Gertjan J Driessen, Jan A Hazelzet
The host response to infection involves complex interplays between inflammation, coagulation, and fibrinolysis. Deregulation of hemostasis and fibrinolysis are major causes of critical illness and important determinants of outcome in severe sepsis. The hemostatic responses to infection vary widely between individuals, and are in part explained by polymorphisms in genes responsible for the protein C and fibrinolytic pathway. This review gives an overview of genetic polymorphisms in the protein C and fibrinolytic pathway associated with susceptibility and severity of pediatric sepsis...
December 15, 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/27964804/the-versatile-platelet-contributes-to-inflammation-infection-hemostasis-coagulation-and-cancer
#18
EDITORIAL
Paul Kubes
No abstract text is available yet for this article.
December 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27956417/effects-of-oritavancin-on-coagulation-tests-in-the-clinical-laboratory
#19
Adam Belley, Richard Robson, John L Francis, Dorothy M Adcock, Stefan Tiefenbacher, Christopher M Rubino, Greg Moeck, David Sylvester, Michael N Dudley, Jeffery Loutit
Previous studies have shown that some lipoglycopeptide and lipopeptide antimicrobial agents may cause falsely elevated values for some phospholipid-dependent coagulation tests. The effect of oritavancin, a lipoglycopeptide antibiotic, on coagulation test results was explored using pooled human plasma samples spiked with drug and in a clinical study after an infusion of a single 1200 mg intravenous dose of oritavancin in normal healthy volunteers. Pooled plasma with oritavancin added ex vivo showed concentration-dependent prolongation of prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT) and the dilute Russell viper venom test (DRVVT)...
December 12, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27951728/effects-of-astaxanthin-on-blood-coagulation-fibrinolysis-and-platelet-aggregation-in-hyperlipidemic-rats
#20
Zu-Yue Deng, Wei-Guang Shan, Shen-Feng Wang, Meng-Mei Hu, Yan Chen
CONTEXT: Astaxanthin (ASTX) is a xanthophyll carotenoid that reduces hemostasis in hyperlipidemic organisms. Its antihemostatic mechanisms remain unclear. OBJECTIVE: The effects of ASTX on coagulation, the fibrinolytic system and platelet aggregation were investigated in hyperlipidemic rats. MATERIALS AND METHODS: Different doses of ASTX (5, 10 and 30 mg/kg/day, p.o.) were administered for four weeks to high-fat diet-induced hyperlipidemic rats...
December 2017: Pharmaceutical Biology
keyword
keyword
48012
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"