keyword
https://read.qxmd.com/read/38445084/a-streamlined-multidisciplinary-metabolic-clinic-in-psychiatric-recovery-service-a-pilot-study
#21
JOURNAL ARTICLE
Kelvin Cy Leung, Bianca Bakr, Cindy Chung, Mayuri Parmar, James Elhindi, Vlasios Brakoulias
BACKGROUND: The metabolic syndrome (MetS) is a collection of risk factors for cardiovascular disease and type-2 diabetes, that includes central obesity, hypertension, hyperglycaemia and dyslipidaemia. An audit indicated inadequate MetS screening in an Australian psychiatric recovery service. OBJECTIVES: We aimed to improve MetS screening, identification and intervention by offering streamlined lifestyle education, clinical reviews and discharge planning. This pilot program prioritized holistic, culturally-sensitive, patient-centric, and trauma-informed approaches to enhance metabolic health outcomes...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38441749/risk-of-systemic-inflammatory-response-syndrome-following-preoperative-glucocorticoids-administration-in-patients-after-percutaneous-nephrolithotomy-a-retrospective-cohort-study
#22
JOURNAL ARTICLE
Jingping Hu, Chaojin Chen, Xiaoyue Li, Xiangyang Zang, Jie Ke, Shaoli Zhou, Haiyan Mai, Chulian Gong
INTRODUCTION: Systemic inflammatory response syndrome (SIRS) is one of the most serious complications in patients undergoing percutaneous nephrolithotomy (PCNL). Although glucocorticoids are increasingly used during PCNL, few studies have been concerned about the association between glucocorticoids and postoperative SIRS. The study aims to explore whether preoperative use of glucocorticoids is associated with SIRS after PCNL. METHODS: A total of 1259 patients who underwent PCNL between January 2015 and April 2021 were enrolled in the retrospective cohort study...
March 5, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38440626/alcohol-sniff-test-ast-an-important-tool-for-screening-post-viral-olfactory-loss-in-acute-flu-like-dysfunction
#23
JOURNAL ARTICLE
Domenico Seabra Modesto, Hugo Machado Silva Neto, Felipe Carvalho Leão, José Arruda Mendes Neto, Fábio Akira Suzuki
Olfactory disorders have a significant impact on patients' quality of life but are often underestimated in clinical practice. Upper respiratory tract infections (URTIs) are a common cause of olfactory loss. While most cases of olfactory loss due to URTIs are conductive and reversible, post-viral olfactory dysfunction (PVOD) persists despite symptom improvement. PVOD is attributed to damage to the olfactory epithelium and nerves or central olfactory pathway lesions. The Alcohol Sniff Test (AST) has been proposed as a tool to assess olfactory function in the acute phase and aid in differentiating PVOD from conductive disorders...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38438967/application-of-metagenomic-next-generation-sequencing-in-the-clinical-diagnosis-of-infectious-diseases-after-allo-hsct-a-single-center-analysis
#24
JOURNAL ARTICLE
Hailong Yuan, Xiaolu Ma, Jianli Xu, Peng Han, Guanhua Rao, Gang Chen, Kaile Zhang, Ruixue Yang, Chuixia Han, Ming Jiang
BACKGROUND: We investigated the value of metagenomic next-generation sequencing (mNGS) in diagnosing infectious diseases in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Fifty-four patients who had fever following allo-HSCT from October 2019 to February 2022 were enrolled. Conventional microbiological tests (CMTs) and mNGS, along with imaging and clinical manifestations, were used to diagnose infection following allo-HSCT...
March 4, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38435525/cellular-repair-of-synthetic-analogs-of-oxidative-dna-damage-reveals-a-key-structure-activity-relationship-of-the-cancer-associated-mutyh-dna-repair-glycosylase
#25
JOURNAL ARTICLE
Savannah G Conlon, Cindy Khuu, Carlos H Trasviña-Arenas, Tian Xia, Michelle L Hamm, Alan G Raetz, Sheila S David
The base excision repair glycosylase MUTYH prevents mutations associated with the oxidatively damaged base, 8-oxo-7,8-dihydroguanine (OG), by removing undamaged misincorporated adenines from OG:A mispairs. Defects in OG:A repair in individuals with inherited MUTYH variants are correlated with the colorectal cancer predisposition syndrome known as MUTYH -associated polyposis (MAP). Herein, we reveal key structural features of OG required for efficient repair by human MUTYH using structure-activity relationships (SAR)...
February 28, 2024: ACS Central Science
https://read.qxmd.com/read/38403573/defective-exercise-related-expiratory-muscle-recruitment-in-patients-with-phox2b-mutations-a-clue-to-neural-determinants-of-the-congenital-central-hypoventilation-syndrome
#26
JOURNAL ARTICLE
P Laveneziana, Q Fossé, M Bret, M Patout, B Dudoignon, C Llontop, C Morélot-Panzini, F Cayetanot, L Bodineau, C Straus, T Similowski
INTRODUCTION AND OBJECTIVES: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study...
February 24, 2024: Pulmonology
https://read.qxmd.com/read/38397842/nmda-receptors-regulate-oxidative-damage-in-keratinocytes-during-complex-regional-pain-syndrome-in-hacat-cells-and-male-rats
#27
JOURNAL ARTICLE
Bei Wen, He Zhu, Jijun Xu, Li Xu, Yuguang Huang
Complex regional pain syndrome (CRPS), a type of primary chronic pain, occurs following trauma or systemic disease and typically affects the limbs. CRPS-induced pain responses result in vascular, cutaneous, and autonomic nerve alterations, seriously impacting the quality of life of affected individuals. We previously identified the involvement of keratinocyte N -methyl-d-asparagic acid (NMDA) receptor subunit 2 B (NR2B) in both peripheral and central sensitizations in CRPS, although the mechanisms whereby NR2B functions following activation remain unclear...
February 18, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38396417/clinical-biochemistry-of-serum-troponin
#28
REVIEW
Ilhan Gokhan, Weilai Dong, Daniel Grubman, Kenechukwu Mezue, David Yang, Yanting Wang, Parul U Gandhi, Jennifer M Kwan, Jiun-Ruey Hu
Accurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS). Knowledge of the molecular characteristics of the troponin complex and test characteristics of troponin measurement assays allows for a deeper understanding of causes of false positive and false negative test results in myocardial injury. In this review, we discuss the molecular structure and functions of the constituent proteins of the troponin complex (TnT, TnC, and TnI); review the different isoforms of Tn and where they are from; survey the evolution of clinical Tn assays, ranging from first-generation to high-sensitivity (hs); provide a primer on statistical interpretation of assay results based on different clinical settings; and discuss potential causes of false results...
February 9, 2024: Diagnostics
https://read.qxmd.com/read/38383671/elevated-serum-levels-of-leukocyte-cell-derived-chemotaxin-2-are-associated-with-the-prevalence-of-metabolic-syndrome
#29
JOURNAL ARTICLE
Xialei Zheng, Junmi Lu, Shaojun Xiang, Pu Zou, Hao Chen, Jing Liu, Cheng Zeng, Yuhu He
AIMS: Inflammation is central to the pathogenesis of metabolic syndrome (MetS). Leukocyte cell-derived chemotaxin 2 (LECT2) is constitutively secreted in response to inflammatory stimuli and oxidative stress contributing to tissue or systemic inflammation. We explored the relationship between LECT2 levels and MetS severity in humans and mice. METHODS: Serum LECT2 levels were measured in 210 participants with MetS and 114 without MetS (non-MetS). LECT2 expression in the liver and adipose tissue was also examined in mice fed a high-fat diet (HFD) and genetically obese (ob/ob) mice...
February 22, 2024: Acta Diabetologica
https://read.qxmd.com/read/38380024/-klebsiella-pneumoniae-invasive-syndrome-with-pneumocephalus-and-extensive-cerebral-infarction-case-report
#30
Liangzhe Wu, Changhong Mo, Yihan Xiong, Yanhui Chen, Meng Jin, Kunning Han, Xuejun Fu
A 54-year-old female with diabetes was admitted with fever and altered consciousness. Laboratory tests revealed venous blood glucose level of 43.79 mmol/L. Computed tomography (CT) scans of the head, chest, and abdomen showed a right-sided pneumothorax, consolidation, and atelectasis in the right lung; a large heterogeneous density lesion with fluid and gas-fluid levels in the liver; and scattered gas shadows in both kidneys, respectively. Blood and puncture fluid cultures indicated infection with Klebsiella pneumoniae ...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38378321/macklin-effect-from-pathophysiology-to-clinical-implication
#31
JOURNAL ARTICLE
Matteo Angelini, Alessandro Belletti, Giovanni Landoni, Alberto Zangrillo, Francesco De Cobelli, Diego Palumbo
Air leak syndromes (such as pneumomediastinum, pneumothorax, or subcutaneous emphysema) are frequent complications of acute respiratory distress syndrome (ARDS). Unfortunately, the development of air leaks is associated with worse outcomes. In addition, it has been hypothesized that the development of pneumomediastinum could be a marker of disease severity in patients with respiratory failure receiving noninvasive respiratory support or assisted ventilation. The so-called Macklin effect (or pulmonary interstitial emphysema) is the air dissection of the lung bronchovascular tree from peripheral to central airways following injury to distal alveoli...
December 19, 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38353355/monitoring-of-physiologic-features-and-treatment-aspects-of-children-on-home-invasive-mechanical-ventilation
#32
JOURNAL ARTICLE
Jasneek Chawla, Hui-Leng Tan
Pediatric home invasive mechanical ventilation patients are a small but resource-intensive cohort, requiring close monitoring and multidisciplinary care. Patients are often dependent on their ventilator for life support, with any significant complications such as equipment failure, tracheostomy blockage, or accidental decannulation becoming potentially life-threatening if not identified quickly. This review discusses the indications and variations in practice worldwide, in terms of models of care, including home care provision, choice of equipment, and monitoring...
February 14, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38353051/overexpression-of-ephb2-in-the-basolateral-amygdala-is-crucial-for-inducing-visceral-pain-sensitization-in-rats-subjected-to-water-avoidance-stress
#33
JOURNAL ARTICLE
Guang-Bing Duan, Jun-Wen Wang, Hui-Hui Sun, Zhi-Yu Dong, Yan Zhang, Zhen-Xiang Wang, Ye Chen, Ying Chen, Ying Huang, Shu-Chang Xu
AIMS: Basolateral amygdala (BLA), as a center for stress responses and emotional regulation, is involved in visceral hypersensitivity of irritable bowel syndrome (IBS) induced by stress. In the present study, we aimed to investigate the role of EphB2 receptor (EphB2) in BLA and explore the underlying mechanisms in this process. METHODS: Visceral hypersensitivity was induced by water avoidance stress (WAS). Elevated plus maze test, forced swimming test, and sucrose preference test were applied to assess anxiety- and depression-like behaviors...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38352712/accuracy-of-the-10-%C3%AE-g-desmopressin-test-for-differential-diagnosis-of-cushing-syndrome-a-systematic-review-and-meta-analysis
#34
Rodrigo Rosa Giampietro, Marcos Vinicius Gama Cabral, Elizandra Gomes Pereira, Marcio Carlos Machado, Lucio Vilar, Vania Dos Santos Nunes-Nogueira
UNLABELLED: We evaluated the accuracy of the 10 μg desmopressin test in differentiating Cushing disease (CD) from non-neoplastic hypercortisolism (NNH) and ectopic ACTH syndrome (EAS). A systematic review of studies on diagnostic test accuracy in patients with CD, NNH, or EAS subjected to the desmopressin test obtained from LILACS, PubMed, EMBASE, and CENTRAL databases was performed. Two reviewers independently selected the studies, assessed the risk of bias, and extracted the data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38347272/subgroup-characteristics-in-care-workers-with-low-back-pain-cluster-analysis-based-severity-of-central-sensitivity-syndromes-and-low-back-pain
#35
JOURNAL ARTICLE
Hayato Shigetoh, Teppei Abiko, Michie Ohyama, Eiji Sakata, Shin Murata
PURPOSE: This multicentre, collaborative, cross-sectional study aimed to explore the characteristics of subgroups based on central sensitivity syndromes (CSSs) and low back pain (LBP) severity. Furthermore, we investigated the relationship between the classified subgroups and work status among the care workers. PATIENTS AND METHODS: In 660 care workers, we assessed LBP intensity, pain duration, pain sites, CSS (using the central sensitization inventory-9), psychological factors (using the pain catastrophizing scale and pain self-efficacy questionnaire), and work status (interference, amount of assistance, frequency of assistance, and work environment)...
February 12, 2024: European Spine Journal
https://read.qxmd.com/read/38342740/health-personnel-perception-about-central-sensitivity-syndrome-fibromyalgia-patients
#36
JOURNAL ARTICLE
Gastón A Ghio, Angels Jaen Manzanera, Julia Torguet Carbonell, Camila Inés Donoso Isla, Alirio José Falcón Marchena, Silvia Martínez Pardo
BACKGROUND AND OBJECTIVES: Fibromyalgia is characterized by musculoskeletal pain and asthenia of chronic course. Fibromyalgia patients are often a challenge for the health care community as a whole. Existing studies are often limited to the opinion of rheumatologists or family physicians. With this study we seek to know what are the actions, perceptions and knowledge of health professionals as a whole when caring for patients with this disease. MATERIALS AND METHODS: Descriptive cross-sectional study, by means of a self-administered and anonymous survey...
February 10, 2024: Reumatología clinica
https://read.qxmd.com/read/38339265/molecular-genetic-profile-of-myelofibrosis-implications-in-the-diagnosis-prognosis-and-treatment-advancements
#37
REVIEW
Tanvi Verma, Nikolaos Papadantonakis, Deniz Peker Barclift, Linsheng Zhang
Myelofibrosis (MF) is an essential element of primary myelofibrosis, whereas secondary MF may develop in the advanced stages of other myeloid neoplasms, especially polycythemia vera and essential thrombocythemia. Over the last two decades, advances in molecular diagnostic techniques, particularly the integration of next-generation sequencing in clinical laboratories, have revolutionized the diagnosis, classification, and clinical decision making of myelofibrosis. Driver mutations involving JAK2 , CALR , and MPL induce hyperactivity in the JAK-STAT signaling pathway, which plays a central role in cell survival and proliferation...
January 25, 2024: Cancers
https://read.qxmd.com/read/38338173/conservative-management-of-acute-sports-related-concussions-a-narrative-review
#38
REVIEW
Sohaib Kureshi, Maria Mendizabal, John Francis, Hamid R Djalilian
This review explores the application of the conservative management model for pain to sports-related concussions (SRCs), framing concussions as a distinct form of pain syndrome with a pathophysiological foundation in central sensitization. Drawing parallels with proven pain management models, we underscore the significance of a proactive approach to concussion management. Recognizing concussions as a pain syndrome allows for the tailoring of interventions in alignment with conservative principles. This review first covers the epidemiology and controversies surrounding prolonged concussion recovery and persistent post-concussion symptoms (PPCS)...
January 23, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38336728/inflammatory-biomarkers-for-neurobehavioral-dysregulation-in-former-american-football-players-findings-from-the-diagnose-cte-research-project
#39
JOURNAL ARTICLE
Suzan van Amerongen, Surya V Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D Cherry, Charles Bernick, Yonas E Geda, Jennifer V Wethe, Douglas I Katz, Michael L Alosco, Charles H Adler, Laura J Balcer, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H Daneshvar, Elizabeth A Colasurdo, Jeffrey J Iliff, Gail Li, Elaine R Peskind, Martha E Shenton, Eric M Reiman, Jeffrey L Cummings, Robert A Stern
BACKGROUND: Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of the neuropathological entity chronic traumatic encephalopathy (CTE). A core feature of TES is neurobehavioral dysregulation (NBD), a neuropsychiatric syndrome in repetitive head impact (RHI)-exposed individuals, characterized by a poor regulation of emotions/behavior. To discover biological correlates for NBD, we investigated the association between biomarkers of inflammation (interleukin (IL)-1β, IL-6, IL-8, IL-10, C-reactive protein (CRP), tumor necrosis factor (TNF)-α) in cerebrospinal fluid (CSF) and NBD symptoms in former American football players and unexposed individuals...
February 9, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38335922/is-it-really-on-your-hand-spontaneous-sensations-are-not-peripheral-sensations-evidence-from-able-bodied-individuals-and-a-phantom-limb-syndrome-patient
#40
JOURNAL ARTICLE
Sara Salgues, Gaën Plancher, George A Michael
Among other bodily signals, the perception of sensations arising spontaneously on the skin with no external triggers contributes to body awareness. The topic of spontaneous sensations (SPS) being quite recent in the literature, there is still a debate whether this phenomenon is elicited by peripheral cutaneous units' activity underlying tactile perception or originates directly from central mechanisms. In a first experiment, we figured that, if SPS depended on peripheral afferents, their perception on the glabrous hand should relate to the hand tactile sensitivity...
February 8, 2024: Brain and Cognition
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