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https://www.readbyqxmd.com/read/28217695/gut-microbiome-and-chronic-prostatitis-chronic-pelvic-pain-syndrome
#1
REVIEW
Hans C Arora, Charis Eng, Daniel A Shoskes
Analysis of the human microbiome continues to reveal new and previously unrealized associations between microbial dysbiosis and disease. Novel approaches to bacterial identification using culture-independent methods allow practitioners to discern the presence of alterations in the taxa and diversity of the microbiome and identify correlations with disease processes. While some of these diseases that have been extensively studied are well-defined in their etiology and treatment methods (colorectal cancer), others have provided much more significant challenges in both diagnosis and treatment...
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28210270/face-to-face-cognitive-behavioral-therapy-for-irritable-bowel-syndrome-the-effects-on-gastrointestinal-and-psychiatric-symptoms
#2
Hanna Edebol-Carlman, Brjánn Ljótsson, Steven J Linton, Katja Boersma, Martien Schrooten, Dirk Repsilber, Robert J Brummer
Irritable bowel syndrome (IBS) is a gastrointestinal disorder linked to disturbances in the gut-brain axis. Visceral hypersensitivity and pain are hallmarks of IBS and linked to the physiological and psychological burden and to the nonadaptive coping with stress. Cognitive-behavioral therapy (CBT) for IBS has proven effective in reducing gastrointestinal and psychiatric symptoms in IBS by means of coping with stress. The present pilot study evaluated for the first time whether CBT for IBS affected visceral sensitivity and pain...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28190705/risk-of-autoimmune-diseases-and-human-papilloma-virus-hpv-vaccines-six-years-of-case-referent-surveillance
#3
Lamiae Grimaldi-Bensouda, Michel Rossignol, Isabelle Koné-Paut, Alain Krivitzky, Christine Lebrun-Frenay, Johanna Clet, David Brassat, Caroline Papeix, Marc Nicolino, Pierre-Yves Benhamou, Olivier Fain, Nathalie Costedoat-Chalumeau, Marie-France Courcoux, Jean-François Viallard, Bertrand Godeau, Thomas Papo, Patrick Vermersch, Isabelle Bourgault-Villada, Gerard Breart, Lucien Abenhaim
BACKGROUND: Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization. OBJECTIVES: To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France. METHODS: Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Cases were female 11-25 years old with incident ADs [central demyelination/multiple sclerosis (CD/MS), connective tissue disease (CTD), Guillain-Barré syndrome (GBS), type-1 diabetes (T1D), autoimmune thyroiditis (AT), and idiopathic thrombocytopenic purpura (ITP)]...
February 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28162043/chest-ultrasonography-in-health-surveillance-of-asbestos-related-lung-diseases
#4
Andrea Smargiassi, Giuliana Pasciuto, Ilaria Pedicelli, Erminia Lo Greco, Mariarosaria Calvello, Riccardo Inchingolo, Gioacchino Schifino, Patrizio Capoluongo, Pasquale Patriciello, Maurizio Manno, Alfonso Cirillo, Giuseppe Maria Corbo, Gino Soldati, Ivo Iavicoli
OBJECTIVES: Exposure to asbestos fibers can lead to different lung diseases, such as pleural thickening and effusion, asbestosis, mesothelioma, and lung cancer. These diseases are expected to peak in the next few years. The aim of the study was to validate ultrasonography (US) as a diagnostic tool in the management of lung diseases in subjects with a history of occupational exposure to asbestos. METHODS: Fifty-nine retired male workers previously exposed to asbestos were enrolled in the study...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28161767/pain-extent-is-associated-with-pain-intensity-but-not-with-widespread-pressure-or-thermal-pain-sensitivity-in-women-with-fibromyalgia-syndrome
#5
Marco Barbero, César Fernández-de-Las-Peñas, María Palacios-Ceña, Corrado Cescon, Deborah Falla
Widespread pain is considered a sign of central sensitization in people with chronic pain. Our aim was to examine whether pain extent, assessed from the pain drawing, relates to measures from quantitative sensory testing in fibromyalgia syndrome (FMS). Thirty women with FMS and no other co-morbid conditions completed pain drawings (dorsal and ventral views) and clinical and related disability questionnaires. Pain extent and pain frequency maps were obtained from the pain drawings using a novel customized software...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28158150/electric-stimulation-for-pain-relief-in-patients-with-fibromyalgia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Ana Paula de Silva Salazar, Cinara Stein, Ritchele Redivo Marchese, Rodrigo Della Mea Plentz, Aline De Souza Pagnussat
BACKGROUND: Fibromyalgia (FM) is a syndrome whose primary symptoms include chronic widespread muscle pain and fatigue. The treatment of patients with FM aims to provide symptomatic relief and improvement in physical capacities to perform daily tasks and quality of life. Invasive or non-invasive electric stimulation (ES) is used for pain relief in patients with FM. OBJECTIVE: This systematic review aimed to assess the effects of treatment with ES, combined or not combined with other types of therapy, for pain relief in patients with FM...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28155627/surrogates-of-insulin-sensitivity-and-indices-of-cardiometabolic-profile-in-obesity
#7
Djordje S Popovic, Edita Stokic, Milena Mitrovic, Dragana Tomic-Naglic, Radoslav Pejin, Tijana Icin, Bojan Vukovic, Zeljko Zivanovic, Sladjana Pejakovic, Branka Kovacev-Zavisic
BACKGROUND AND OBJECTIVES: Obesity is often associated with insulin resistance (IR). We considered different IR indexes: the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, the two specimen (0 and 120 min) oral glucose tolerance test Matsuda Index (MI) and the Homeostasis Model Assessment-Adiponectin (HOMA-AD) index. These IR indexes were compared with indicators of the cardiometabolic profile. METHOD: This cross-sectional study enrolled 60 obese individuals without previous history of diabetes...
February 2, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28146319/unimpaired-endogenous-pain-inhibition-in-the-early-phase-of-complex-regional-pain-syndrome
#8
N Kumowski, T Hegelmaier, J Kolbenschlag, C Maier, T Mainka, J Vollert, E Enax-Krumova
BACKGROUND: The complex regional pain syndrome (CRPS) is characterized by distal generalisation of pain beyond the initial trauma. This might be the result of impaired endogenous pain inhibition. METHOD: We compared Conditioned Pain Modulation (CPM) between patients with CRPS (n = 24; pain: 4.5 ± 2.2, NRS 0-10; disease duration <1 year), neuralgia (n = 17; pain: 5.5 ± 1.1) and healthy subjects (n = 23) and its correlation with loss and gain of function as assessed by Quantitative Sensory Testing (QST)...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28128429/-neurofibromatosis-type-2-in-childhood-a-clinical-characterization
#9
C M Hinojosa-Mateo, J A Reche-Sainz, A Hernandez-Nunez, M Ramos-Lopez, A Arpa-Fernandez, D Natera-de Benito
INTRODUCTION: Neurofibromatosis type 2 (NF2) is a dominantly inherited neuroectodermal syndrome that predispose to the development of tumors of the central and peripheral nervous system. Additional features include eye and skin abnormalities. CASE REPORT: A 12-year old male with diagnosis of MF2 according to Baser et al and presentation in childhood was included. A comprehensive bibliographic review of evolution of the diagnostic criteria for NF2 in children was performed...
February 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28125531/repeated-binge-like-alcohol-intoxication-depot-specific-adipose-tissue-immuno-metabolic-dysregulation
#10
Flavia M Souza-Smith, Stephen M Ford, Liz Simon, Patricia E Molina
Repeated binge-like alcohol intoxication (RBAI) induces whole-body insulin resistance, which is predicted to increase the risk for metabolic syndrome and type 2 diabetes. Previously we showed that acute alcohol intoxication increases mesenteric lymphatic permeability, perilymphatic adipose tissue (PLAT) inflammation, and circulating lipopolysaccharide (LPS) levels in rats. We hypothesize that mesenteric lymphatic hyperpermeability, adipose tissue inflammation and associated dysregulated adipokine expression and insulin signaling are central mechanisms underlying whole body metabolic dysregulation resulting from RBAI...
January 25, 2017: Shock
https://www.readbyqxmd.com/read/28123024/dna-pkcs-atm-and-atr-interplay-maintains-genome-integrity-during-neurogenesis
#11
Vanessa Enriquez-Rios, Lavinia C Dumitrache, Susanna M Downing, Yang Li, Eric J Brown, Helen R Russell, Peter J McKinnon
: The DNA damage response (DDR) orchestrates a network of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome stability. DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded by PRKDC), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related) are related PI3K-like protein kinases and central regulators of the DDR. Defects in these kinases have been linked to neurodegenerative or neurodevelopmental syndromes...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28110716/automated-diagnosis-of-macular-edema-and-central-serous-retinopathy-through-robust-reconstruction-of-3d-retinal-surfaces
#12
Adeel M Syed, Taimur Hassan, M Usman Akram, Samra Naz, Shehzad Khalid
BACKGROUND AND OBJECTIVES: Macular diseases tend to damage macula within human retina due to which the central vision of a person is affected. Macular edema (ME) and central serous retinopathy (CSR) are two of the most common macular diseases. Many researchers worked on automated detection of ME from optical coherence tomography (OCT) and fundus images, whereas few researchers have worked on diagnosing central serous retinopathy. But this paper proposes a fully automated method for the classification of ME and CSR through robust reconstruction of 3D OCT retinal surfaces...
December 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28106318/reduced-laser-evoked-potential-habituation-detects-abnormal-central-pain-processing-in-painful-radiculopathy-patients
#13
P Hüllemann, C von der Brelie, G Manthey, J Düsterhöft, A K Helmers, M Synowitz, R Baron
BACKGROUND: Repetitive painful laser stimuli lead to physiological laser-evoked potential (LEP) habituation, measurable by a decrement of the N2/P2 amplitude. The time course of LEP-habituation is reduced in the capsaicin model for peripheral and central sensitization and in patients with migraine and fibromyalgia. In the present investigation, we aimed to assess the time course of LEP-habituation in a neuropathic pain syndrome, i.e. painful radiculopathy. METHODS: At the side of radiating pain, four blocks of 25 painful laser stimuli each were applied to the ventral thigh at the L3 dermatome in 27 patients with painful radiculopathy...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28092404/metformin-versus-myoinositol-which-is-better-in-obese-pcos-patients-a-randomized-controlled-crossover-study
#14
Valeria Tagliaferri, Daniela Romualdi, Valentina Immediata, Simona De Cicco, Christian Di Florio, Antonio Lanzone, Maurizio Guido
CONTEXT: due to the central role of metabolic abnormalities in the pathophysiology of PCOS, insulin sensitising agents have been proposed as a feasible treatment option. OBJECTIVE: to investigate which is the more effective between metformin and myoinositol on hormonal, clinical and metabolic parameters in obese patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: crossover randomized-controlled study. PATIENTS: Thirty-four PCOS obese women (age: 25...
January 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28087351/central-nervous-system-vasculitis-in-adults-an-update
#15
REVIEW
Lívia Almeida Dutra, Alexandre Wagner Silva de Souza, Gabriela Grinberg-Dias, Orlando Graziani Povoas Barsottini, Simone Appenzeller
Primary central nervous system vasculitis (PCNSV) is a challenging diagnosis due to broad clinical manifestations and variable specificity and sensitivity of laboratory and imaging diagnostic tools. Differential diagnosis includes reversible cerebral vasoconstriction syndrome (RCVS), secondary vasculitis of the CNS and other noninflammatory vasculopathies. Brain biopsy is essential for definitive diagnosis and to exclude mimickers. Recent data show that data large-vessel PCNSV present worse prognosis when compared to small-vessel PCNSV...
February 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28086952/glucagon-like-peptide-1-analogues-an-efficient-therapeutic-option-for-the-severe-insulin-resistance-of-lipodystrophic-syndromes-two-case-reports
#16
Joana Oliveira, Eva Lau, Davide Carvalho, Paula Freitas
BACKGROUND: Lipodystrophic syndromes are uncommon medical conditions which are normally associated with metabolic disorders, such as diabetes mellitus, dyslipidemia, and fatty liver disease. These complications are generally difficult to treat, particularly diabetes, due to severe insulin resistance. We present two case reports of successful treatment of diabetes with glucagon-like peptide-1 analogues in patients with clinical features of lipodystrophic syndromes. CASE PRESENTATION: Two white women aged 49 and 60 years manifested marked central body fat deposition with severe lipoatrophy of their limbs and buttocks and pronounced acanthosis nigricans...
January 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#17
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28040285/diagnostic-performance-of-a-high-sensitive-troponin-t-assay-and-a-troponin-t-point-of-care-assay-in-the-clinical-routine-of-an-emergency-department-a-clinical-cohort-study
#18
Anna Slagman, Johannes von Recum, Martin Möckel, Fabian Holert, Dirk Meyer Zum Büschenfelde, Christian Müller, Julia Searle
BACKGROUND: A point of care test (POCT) for troponin T (TnT) in the Emergency Department (ED) was compared to a high-sensitivity TnT (hsTnT) central laboratory test (CLT) to determine the influence of test system and different cut-off values on the diagnostic performance in patients with suspected acute coronary syndrome (ACS) under routine conditions. METHODS: All patients with routine TnT testing in the ED were enrolled. Only internal medicine patients without STEMI and with both troponin values were analyzed...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28025360/patterns-of-cerebral-blood-flow-modulation-during-painful-stimulation-in-fibromyalgia-a-transcranial-doppler-sonography-study
#19
Casandra I Montoro, Stefan Duschek, Cristina Muñóz Ladrón de Guevara, Gustavo A Reyes Del Paso
OBJECTIVE: This study analyzed the temporal dynamics of cerebral blood flow (CBF) modulations, during painful stimulation in fibromyalgia syndrome (FMS), using functional transcranial Doppler sonography. METHOD: Blood flow velocities were recorded bilaterally in the anterior (ACA) and middle (MCA) cerebral arteries of 24 FMS patients and 20 healthy individuals during exposure to painful pressure stimulation. Participants were presented with two stimulation blocks: a) fixed pressure (2...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28019651/infratentorial-superficial-siderosis-classification-diagnostic-criteria-and-rational-investigation-pathway
#20
Duncan Wilson, Fiona Chatterjee, Simon F Farmer, Peter Rudge, Mark O McCarron, Peter Cowley, David J Werring
Central nervous system infratentorial superficial siderosis (iSS) is increasingly detected by blood-sensitive magnetic resonance imaging (MRI) sequences. Despite this, there are no standardized diagnostic criteria, and the clinical-radiological spectrum, causes, and optimum investigation strategy are not established. We reviewed clinical and radiological details of patients with iSS assessed at a specialist neurological center during 2004-2016 using predefined standardized radiological criteria. All imaging findings were rated blinded to clinical details...
December 26, 2016: Annals of Neurology
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