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https://www.readbyqxmd.com/read/29123410/long-noncoding-rna-and-mrna-profiling-in-mda-mb-231-cells-following-rnai-mediated-knockdown-of-sirt7
#1
Kun-Lin Chen, Lian Li, Yi-Ru Wang, Cheng-Min Li, Tarig Mohammed Badri, Gen-Lin Wang
Breast cancer is one of the most common malignant cancers among women and a major clinical obstacle. Although studies have reported the abnormal expression of SIRT7 in breast cancer, whether the function of SIRT7 regulates the expression of long noncoding RNAs (lncRNAs) in breast cancer remains unknown. We aimed to determine the differential expressions of mRNAs and lncRNAs associated with SIRT7 and understand the regulatory mechanism of SIRT7 in breast cancer. RNA sequencing was performed to explore the transcriptome in MDA-MB-231 cells after SIRT7 depletion, and a total of 50,634 different transcripts were identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29115434/n-butanol-extract-from-folium%C3%A2-isatidis-inhibits-the-lipopolysaccharide-induced-downregulation-of-cxcr1-and-cxcr2-on-human-neutrophils
#2
Beibei Wu, Liyin Wang, Lili Jiang, Lili Dong, Fengli Xu, Yili Lu, Jiahui Jin, Zhanyue Wang, Guang Liang, Xiaoou Shan
Neutrophils, immune cells crucial for protecting against invading pathogens, are important in sepsis. Neutrophil migration is regulated by chemokine receptors and their cognate ligands. Our previous study investigated the effect of n‑butanol extract from Folium isatidis on lipopolysaccharide (LPS)‑induced septic shock. The present study stimulated neutrophils with LPS to explore the influence of LPS on cell. Neutrophils were then pretreated with n‑butanol extract from Folium isatidis followed by LPS to examine the effect of this extract on neutrophil chemotaxis...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29105544/human-acellular-amniotic-membrane-a-potential-osteoinductive-biomaterial-for-bone-regeneration
#3
Kai Tang, Jiayi Wu, Zekang Xiong, Yanhui Ji, Tingfang Sun, Xiaodong Guo
Human acellular amniotic membrane is an acellular, naturally extracellular matrix material with various bioactive factors, which applied in tissue engineering in clinic. Several studies have applied human acellular amniotic membrane in skin and ocular surface tissue engineering to enhance tissue regeneration. However, the application of human acellular amniotic membrane in bone tissue engineering was rarely investigated. The aim of the current study was to investigate the osteoinductivity, angiogenesis and the early molecular changes of human acellular amniotic membrane to bone regeneration...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29089446/mir-505-3p-controls-chemokine-receptor-up-regulation-in-macrophages-role-in-familial-hypercholesterolemia
#4
Rafael Escate, Pedro Mata, Jose Maria Cepeda, Teresa Padró, Lina Badimon
Familial hypercholesterolemia (FH) conveys a high risk of premature atherosclerosis as a result of lifelong exposure to high LDL cholesterol levels that are not fully reduced by standard-of-care lipid-lowering treatment. Inflammatory mediators have played a role in the progression of atherosclerotic lesions. Here, we investigated whether innate immunity cells in patients with FH have a specific proinflammatory phenotype that is distinct from that of cells in normal participants. To this end, miR-505-3p-a microRNA related to chronic inflammation-and its target genes were investigated in monocyte-derived macrophages (MACs) of patients with FH (FH-MACs) and non-FH controls (co-MACs)...
October 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29025291/-waldenstr%C3%A3-m-s-macroglobulinemia-and-its-individualized-therapy-options
#5
Zsuzsanna Szemlaky, Gábor Mikala
Waldenström's macroglobulinaemia is a form of lymphoplasmocytic lymphoma that preferentially localizes to the bone marrow and causes a special syndrome characterized by monoclonal IgM hypersecretion. Recent results point to the fact that this disease has at least three different pathobiological forms with different clinical presentation. While mutations of MYD88 occur in 95-97% of the cases, there are CXCR4 mutations in 30-40%, ARID1A mutations in 17% and CD79B mutations in approximately 10% of afflicted individuals...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28928094/identification-of-hypoxia-regulated-angiogenic-genes-in-colorectal-cancer
#6
Shaoqi Zong, Wen Li, Hongjia Li, Susu Han, Shanshan Liu, Qi Shi, Fenggang Hou
The tumour hypoxia would trigger the angiogenesis switch for survival, and increase the ability of cancer cells to invade and metastasis. However, hypoxia regulated genes that invovled in angiogenesis in colorectal cancer (CRC) have not been explored in detail. The aim of this study was to explore angiogenic genes under hypoxia condition in CRC. Here, we found that endothelial cells tube formation and cancer cells invasion ability were promoted even under chronic hypoxia condition (72 h) in colon adenocarcinoma HCT-116 cells...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28901471/cxc-chemokine%C3%A2-7-inhibits-growth-and-migration-of-oral-tongue-squamous-cell-carcinoma-cells-mediated-by-the-epithelial%C3%A2-mesenchymal-transition-signaling-pathway
#7
Tong-Jun Liu, Jian-Lian Guo, Xin Xu
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral malignancy with different histopathological symptoms and etiology of tumorigenesis. Migration and invasion is the most important characteristics of OTSCC, and limits tumor therapy in clinics. The epithelial‑to‑mesenchymal transition (EMT) signaling pathway is an important process in the progress of tumor cell migration and invasion. Previous studies have indicated that C‑X‑C chemokine receptor‑7 (CXCR‑7) promotes the progression and metastasis of tumor cells, presenting a potential target molecule for cancer therapy...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28870858/molecular-characterization-and-expression-analysis-of-the-large-yellow-croaker-larimichthys-crocea-chemokine-receptors-cxcr2-cxcr3-and-cxcr4-after-bacterial-and-poly-i-c-challenge
#8
Xiaoxu Liu, Lisen Kang, Wei Liu, Bao Lou, Changwen Wu, Lihua Jiang
The large yellow croaker (Larimichthys crocea) has a well-developed innate immune system. We studied a component of this system, chemokine receptor CXCR family. In this study, we report the full-length open reading frames, as well as the identification and characterization of the chemokine receptor genes CXCR2 (LycCXCR2), CXCR3 (LycCXCR3), and CXCR4 (LycCXCR4) of large yellow croaker. We report that LycCXCR3 and LycCXCR4 are evolving neutrally according to PAML analyses. Quantitative real-time PCR analysis revealed that CXCR transcripts were expressed in all examined tissues...
September 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28862946/%C3%AE-1-adrenergic-receptors-function-within-hetero-oligomeric-complexes-with-atypical-chemokine-receptor-3-and-chemokine-c-x-c-motif-receptor-4-in-vascular-smooth-muscle-cells
#9
Lauren J Albee, Jonathan M Eby, Abhishek Tripathi, Heather M LaPorte, Xianlong Gao, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak
BACKGROUND: Recently, we provided evidence that α1-adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1-ARs through formation of heteromeric receptor complexes in human vascular smooth muscle cells (hVSMCs), the molecular basis underlying cross-talk between ACKR3 and α1-ARs is unknown. METHODS AND RESULTS: We show that ACKR3 agonists inhibit inositol trisphosphate production in hVSMCs on stimulation with phenylephrine...
August 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28845522/adipochemokines-induced-by-ultraviolet-irradiation-contribute-to-impaired-fat-metabolism-in-subcutaneous-fat-cells
#10
E J Kim, Y K Kim, S Kim, J E Kim, Y D Tian, E J Doh, D H Lee, J H Chung
BACKGROUND: Adipose tissue is now appreciated as the pivotal regulator of metabolic and endocrine functions. Subcutaneous (SC) fat, in contrast to visceral fat, may protect against metabolic syndrome and systemic inflammation. We demonstrated that chronic as well as acute UV exposure to the skin induces loss of underlying SC fat. UV-irradiated SC fat may produce chemokines or cytokines which modulate lipid homeostasis and secretion of adipokines. OBJECTIVES: We aim to elucidate UV-induced specific adipochemokines implicated in UV-induced modulation of SC fat...
August 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28842182/the-cc-and-cxc-chemokine-receptors-in-channel-catfish-ictalurus-punctatus-and-their-involvement-in-disease-and-hypoxia-responses
#11
Qiang Fu, Yujia Yang, Chao Li, Qifan Zeng, Tao Zhou, Ning Li, Yang Liu, Shikai Liu, Zhanjiang Liu
Chemokines are vital regulators of cell mobilization for immune surveillance, inflammation, and development. Chemokines signal through binding to their receptors that are a superfamily of seven-transmembrane domain G-coupled receptors. Recently, a complete repertoire of both CC and CXC chemokines have been identified in channel catfish, but nothing is known about their receptors. In this study, a set of 29 CC chemokine receptor (CCR) genes and 8 CXC chemokine receptor (CXCR) genes were identified and annotated from the channel catfish genome...
August 29, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28814754/unveiling-cerebral-leishmaniasis-parasites-and-brain-inflammation-in-leishmania-donovani-infected-mice
#12
Guilherme D Melo, Sophie Goyard, Laurence Fiette, Alexandre Boissonnas, Christophe Combadiere, Gisele F Machado, Paola Minoprio, Thierry Lang
Visceral leishmaniasis (VL) is a systemic disease with multifaceted clinical manifestations, including neurological signs, however, the involvement of the nervous system during VL is underestimated. Accordingly, we investigated both brain infection and inflammation in a mouse model of VL. Using bioluminescent Leishmania donovani and real-time 2D-3D imaging tools, we strikingly detected live parasites in the brain, where we observed a compartmentalized dual-phased inflammation pattern: an early phase during the first two weeks post-infection, with the prompt arrival of neutrophils and Ly6C(high) macrophages in an environment presenting a variety of pro-inflammatory mediators (IFN-γ, IL-1β, CXCL-10/CXCR-3, CCL-7/CCR-2), but with an intense anti-inflammatory response, led by IL-10; and a re-inflammation phase three months later, extremely pro-inflammatory, with novel upregulation of mediators, including IL-1β, TNF-α and MMP-9...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790053/progenitor-cells-and-clinical-outcomes-in-patients-with-heart-failure
#13
Ayman Samman Tahhan, Muhammad Hammadah, Pratik B Sandesara, Salim S Hayek, Andreas P Kalogeropoulos, Ayman Alkhoder, Heval Mohamed Kelli, Matthew Topel, Nima Ghasemzadeh, Kaavya Chivukula, Yi-An Ko, Hiroshi Aida, Iraj Hesaroieh, Ernestine Mahar, Jonathan H Kim, Peter Wilson, Leslee Shaw, Viola Vaccarino, Edmund K Waller, Arshed A Quyyumi
BACKGROUND: Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease. However, their predictive role in heart failure (HF) remains controversial. We assessed the relationship between the number of circulating PCs and the pathogenesis and severity of HF and their impact on incident HF events. METHODS AND RESULTS: We recruited 2049 adults of which 651 had HF diagnosis...
August 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28763008/omega-3-fatty-acids-supplementation-differentially-modulates-the-sdf-1-cxcr-4-cell-homing-axis-in-hypertensive-and-normotensive-rats
#14
Luiza Halmenschlager, Alexandre Machado Lehnen, Aline Marcadenti, Melissa Medeiros Markoski
BACKGROUND: We assessed the effect of acute and chronic dietary supplementation of ω-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. METHODS: Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were allocated in eight groups (of eight animals each), which received daily orogastric administration of ω-3 (1 g) for 24 h, 72 h or 2 weeks...
August 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28761757/mechanisms-of-action-and-rationale-for-the-use-of-checkpoint-inhibitors-in-cancer
#15
REVIEW
Clemence Granier, Eleonore De Guillebon, Charlotte Blanc, Helene Roussel, Cecile Badoual, Elia Colin, Antonin Saldmann, Alain Gey, Stephane Oudard, Eric Tartour
The large family of costimulatory molecules plays a crucial role in regulation of the immune response. These molecules modulate TCR signalling via phosphorylation cascades. Some of the coinhibitory members of this family, such as PD-1 and CTLA-4, already constitute approved targets in cancer therapy and, since 2011, have opened a new area of antitumour immunotherapy. Many antibodies targeting other inhibitory receptors (Tim-3, VISTA, Lag-3 and so on) or activating costimulatory molecules (OX40, GITR and so on) are under evaluation...
2017: ESMO Open
https://www.readbyqxmd.com/read/28740515/in-vivo-tracking-of-chemokine-receptor-cxcr4-engineered-mesenchymal-stem-cell-migration-by-optical-molecular-imaging
#16
Senthilkumar Kalimuthu, Ji Min Oh, Prakash Gangadaran, Liya Zhu, Ho Won Lee, Ramya Lakshmi Rajendran, Se Hwan Baek, Yong Hyun Jeon, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
CXCR4, the stromal cell-derived factor-1 receptor, plays an important role in the migration of hematopoietic progenitor/stem cells to injured and inflamed areas. Noninvasive cell tracking methods could be useful for monitoring cell fate. Therefore, in this study, we evaluated the efficacy of an intravenous infusion of genetically engineered mesenchymal stem cells (MSCs) overexpressing CXC chemokine receptor 4 (CXCR4) to home to the tumor, by optical imaging. We constructed a retroviral vector containing CXCR with dual reporter genes, eGFP and Fluc2, under the control of an EF1α promoter (pBABE-EF1α-CXCR4-eGFP-IRES-Fluc2)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28739729/the-axis-of-cxcr4-sdf-1-plays-a-role-in-colon-cancer-cell-adhesion-through-regulation-of-the-akt-and-igf1r-signalling-pathways
#17
Fei Zheng, Zhongtao Zhang, Valentina Flamini, Wen G Jiang, Yuxin Cui
BACKGROUND/AIM: Colorectal cancer (CRC) is the third most common cancer in the world. The high mortality of this tumor is mainly due to its invasive properties, as it forms metastases in multiple organs, preferentially in the liver. There has evidence showing that C-X-C chemokine receptor type 4 (CXCR-4) and its ligand, stromal cell-derived factor-1 (SDF-1), plays an important role in cancer progression and metastasis. However, the molecular mechanism underling the CRCR4-mediated CRC metastasis has not been well characterized...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28703769/glycosaminoglycans-regulate-cxcr3-ligands-at-distinct-levels-protection-against-processing-by-dipeptidyl-peptidase-iv-cd26-and-interference-with-receptor-signaling
#18
Mieke Metzemaekers, Anneleen Mortier, Rik Janssens, Daiane Boff, Lotte Vanbrabant, Nicole Lamoen, Jo Van Damme, Mauro M Teixeira, Ingrid De Meester, Flávio A Amaral, Paul Proost
CXC chemokine ligand (CXCL)9, CXCL10 and CXCL11 direct chemotaxis of mainly T cells and NK cells through activation of their common CXC chemokine receptor (CXCR)3. They are inactivated upon NH₂-terminal cleavage by dipeptidyl peptidase IV/CD26. In the present study, we found that different glycosaminoglycans (GAGs) protect the CXCR3 ligands against proteolytic processing by CD26 without directly affecting the enzymatic activity of CD26. In addition, GAGs were shown to interfere with chemokine-induced CXCR3 signaling...
July 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28685587/3-dimensional-nano-fibre-scaffold-for-ex-vivo-expansion-of-cord-blood-haematopoietic-stem-cells
#19
Seyed Hadi Mousavi, Saeid Abroun, Masoud Soleimani, Seyed Javad Mowla
Cord blood (CB) haematopoietic stem cell (HSC) is an alternative source of HSC transplantation. The limited cell number greatly restricts their clinic-scale therapeutic applications. The objective of this study was an ex vivo expansion of CB HSCs in a new three-dimensional polycaprolactone nano-scaffold coated with fibronectin (FN). First, we isolated CB CD34+ cells and cultured 10 days in presence of growth factors. The evaluation was performed by qRT-PCR, flow cytometry and clonogenicity. 3D PCL nano-scaffold coated with FN produced significantly higher total nucleated cells and CD34+ cells (p < ...
July 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28608561/angiogenic-and-restorative-abilities-of-human-mesenchymal-stem-cells-were-reduced-following-treatment-with-serum-from-diabetes-mellitus-type-2-patients
#20
Jafar Rezaie, Malek S Mehranjani, Reza Rahbarghazi, Mohammad A Shariatzadeh
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level of Ang-1, Ang-2, cell migration, and trans-differentiation into pericytes and endothelial lineage were monitored after 7 days. The interaction of mesenchymal stem cells with endothelial cells were evaluated using surface plasmon resonance technique. Paracrine restorative effect of diabetic stem cells was tested on pancreatic β cells...
June 13, 2017: Journal of Cellular Biochemistry
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