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https://www.readbyqxmd.com/read/27906085/tissue-engineered-cardiac-patch-seeded-with-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-promoted-the-regeneration-of-host-cardiomyocytes-in-a-rat-model
#1
Tadahisa Sugiura, Narutoshi Hibino, Christopher K Breuer, Toshiharu Shinoka
BACKGROUND: Thousands of babies are born with congenital heart defects that require surgical repair involving a prosthetic implant. Lack of growth in prosthetic grafts is especially detrimental in pediatric surgery. Cell seeded biodegradable tissue engineered grafts are a novel solution to this problem. The purpose of the present study is to evaluate the feasibility of seeding human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) onto a biodegradable cardiac patch. METHODS: The hiPS-CMs were cultured on a biodegradable patch composed of a polyglycolic acid (PGA) and a 50:50 poly (l-lactic-co-ε-caprolactone) copolymer (PLCL) for 1 week...
December 1, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27905876/age-and-sex-specific-associations-of-anthropometric-measures-of-adiposity-with-blood-pressure-and-hypertension-in-india-a-cross-sectional-study
#2
Kevin Y Taing, Michael E Farkouh, Rahim Moineddin, Jack V Tu, Prabhat Jha
BACKGROUND: A determinant of blood pressure is adiposity; however, there are uncertainties surrounding whether general or central adiposity is the more important determinant of blood pressure. Further, inconsistent results exist for the relationships of anthropometric measures with blood pressure and hypertension, and whether these relationships differ substantially by age and sex is unclear. We aimed to elucidate the associations of anthropometric measures of general and central adiposity with blood pressure and hypertension, and determine the effect of age and sex on these relationships...
December 1, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27905865/transient-bone-marrow-edema-syndrome-versus-osteonecrosis-perfusion-patterns-at-dynamic-contrast-enhanced-mr-imaging-with-high-temporal-resolution-can-allow-differentiation
#3
Tobias Geith, Thomas Niethammer, Stefan Milz, Olaf Dietrich, Maximilian Reiser, Andrea Baur-Melnyk
Purpose To prospectively evaluate the perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging of transient bone marrow edema syndrome (TBMES) and avascular osteonecrosis. Materials and Methods Institutional review board approval and written informed consent were obtained. Thirty-two patients (21 men, 11 women; mean age, 48 years; 26 hips, 10 knees) underwent conventional MR imaging and a dynamic contrast-enhanced three-dimensional spoiled gradient-echo sequence at 3 T...
December 1, 2016: Radiology
https://www.readbyqxmd.com/read/27905187/no-clinically-meaningful-weight-changes-in-a-young-cohort-following-total-joint-arthroplasty-at-3-year-follow-up
#4
Peter M Formby, Richard L Purcell, Michael Baird, Matthew Wagner, Ronald P Goodlett, Andrew W Mack
BACKGROUND: Total joint arthroplasty (TJA) is one of the most successful operations. There is little in the literature regarding weight change following TJA, particularly in a young cohort. METHODS: Retrospective analysis of 181 primary total hip arthroplasty (THA) and 185 primary total knee arthroplasty (TKA) patients was conducted. We reviewed preoperative and post-operative weights and post-operative body mass index at 3 and 6 months, 1 year, 2 and 3 years...
November 30, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27905088/iliopsoas-bursitis-and-femoral-vein-thrombosis-complicating-total-hip-arthroplasty-in-an-elderly-patient
#5
Franca Bilora, Lucia Sarolo, Fabio Pomerri, Paolo Prandoni
No abstract text is available yet for this article.
November 30, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27905061/one-third-of-hips-after-periacetabular-osteotomy-survive-30-years-with-good-clinical-results-no-progression-of-arthritis-or-conversion-to-tha
#6
Till Dominic Lerch, Simon Damian Steppacher, Emanuel Francis Liechti, Moritz Tannast, Klaus Arno Siebenrock
BACKGROUND: Since its first description in 1984, periacetabular osteotomy (PAO) has become an accepted treatment for hip dysplasia. The 30-year survivorship with this procedure has not been reported. Because these patients are often very young at the time of surgery, long-term followup and identification of factors associated with poor outcome could help to improve patient selection. QUESTIONS/PURPOSES: Looking at the initial group of patients with hip dysplasia undergoing PAO at the originator's institution, we asked: (1) What is the cumulative 30-year survival rate free from conversion to THA, radiographic progression of osteoarthritis, and/or a Merle d'Aubigné-Postel score < 15? (2) Did hip function improve and pain decrease? (3) Did radiographic osteoarthritis progress? (4) What are the factors associated with one or more of the three endpoints: THA, radiographic progression of osteoarthritis, and/or Merle d'Aubigné-Postel score < 15? METHODS: We retrospectively evaluated the first 63 patients (75 hips) who underwent PAO for hip dysplasia between 1984 and 1987...
November 30, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27904910/use-of-databases-and-registries-to-understand-post-operative-hip-fracture-management
#7
Dharani Nagarajan
is missing (Letter to the Editor).
November 30, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27904862/risk-factors-for-barrett-s-oesophagus
#8
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Globally, the incidence of OAC is rising. Furthermore, the prognosis regarding the morbidity and mortality of OAC is bleak, with an estimated 5-year survival of 10-15%. Hence, detection of the premalignant phase is paramount. Endoscopy and biopsy sampling is the mainstay of diagnosis. Patients may present with symptoms of gastro-oesophageal reflux disease (GORD) or be completely asymptomatic...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904794/pain-function-and-strength-outcomes-for-males-and-females-with-patellofemoral-pain-who-participate-in-either-a-hip-core-or-knee-based-rehabilitation-program
#9
Lori A Bolgla, Jennifer Earl-Boehm, Carolyn Emery, Karrie Hamstra-Wright, Reed Ferber
BACKGROUND: Hip exercise has been recommended for females with patellofemoral pain (PFP). It is unknown if males with PFP will benefit from a similar treatment strategy. HYPOTHESES/PURPOSE: The purpose of this study was to compare improvements in pain, function, and strength between males and females with PFP who participated in either a hip/core or knee rehabilitation program. The directional hypothesis was that females would respond more favorably to the hip/core rehabilitation program and males to the knee program...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904792/current-concepts-and-treatment-of-patellofemoral-compressive-issues
#10
Michael J Mullaney, Takumi Fukunaga
Patellofemoral disorders, commonly encountered in sports and orthopedic rehabilitation settings, may result from dysfunction in patellofemoral joint compression. Osseous and soft tissue factors, as well as the mechanical interaction of the two, contribute to increased patellofemoral compression and pain. Treatment of patellofemoral compressive issues is based on identification of contributory impairments. Use of reliable tests and measures is essential in detecting impairments in hip flexor, quadriceps, iliotibial band, hamstrings, and gastrocnemius flexibility, as well as in joint mobility, myofascial restrictions, and proximal muscle weakness...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904791/current-concepts-in-biomechanical-interventions-for-patellofemoral-pain
#11
Richard W Willy, Erik P Meira
: Patellofemoral pain (PFP) has historically been a complex and enigmatic issue. Many of the factors thought to relate to PFP remain after patients' symptoms have resolved making their clinical importance difficult to determine. The tissue homeostasis model proposed by Dye in 2005 can assist with understanding and implementing biomechanical interventions for PFP. Under this model, the goal of interventions for PFP should be to re-establish patellofemoral joint (PFJ) homeostasis through a temporary alteration of load to the offended tissue, followed by incrementally restoring the envelope of function to the baseline level or higher...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904729/treatment-of-late-onset-legg-calve-perthes-disease-by-arthrodiastasis
#12
Sung Soo Kim, Chan Woo Lee, Hyeon Jun Kim, Hyun Ho Kim, Lih Wang
BACKGROUND: To evaluate the efficacy of arthrodiastasis for Legg-Calve-Perthes disease. METHODS: Arthrodiastasis was conducted using external fixator devices (Orthofix) in 7 patients at least 8 years of age with a diagnosis of Legg-Calve-Perthes disease. The average follow-up was 80 months (range, 32 to 149 months), and their average age was 9.1 years (range, 8 to 12 years). The results of treatment were evaluated by measuring the degree of hip pain and the range of motion of the hip at 6 months after the operation and comparing the values with preoperative measurements...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27904226/paraplegic-flexion-contracture-of-hip-joints-an-unsolvable-problem
#13
Sailendra Bhattacharyya
Paraplegic flexion contracture of hip joints beyond 90° is a difficult condition to treat for any orthopedic surgeon. There is no fixed protocol of treatment described, by and large it is individualized. A 20 year old female presented with paraplegia for last 15 years due to irrecoverable spinal cord disease with complete sensory and motor loss of both lower extremities and was admitted with acute flexion contracture of both hip joints with trunk resting on thighs. She underwent bilateral proximal femoral resection...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27904221/what-have-we-learned-from-100-success-of-press-fit-condylar-rotating-platform-posterior-stabilized-knees-a-5-10-years-followup-by-a-nondesigner
#14
Shrinand V Vaidya, Siddharth Virani, Rajendra Phunde, Abhishek Mahajan
BACKGROUND: Total joint arthroplasties of the hip and knee represent a remarkable feat of modern medicine in terms of reducing pain and restoring function to millions of patients afflicted with severe arthritis. Oftentimes, the performance and longevity of new implants and devices are based on limited data. This is the first study by a non-designer on the press fit condylar rotating platform posterior stabilized (PFC-RP-PS) design with 100' success. This has a relevance, vis-á -vis bias that one may have in terms of reproducibility of technique and funding from the manufacturer...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27904218/core-decompression-or-quadratus-femoris-muscle-pedicle-bone-grafting-for-nontraumatic-osteonecrosis-of-the-femoral-head-a-randomized-control-study
#15
Deqiang Li, Ming Li, Peilai Liu, Yuankai Zhang, Liang Ma, Fei Xu
BACKGROUND: The traditional management for osteonecrosis of the femoral head (ONFH) includes core decompression (CD) and quadratus femoris muscle pedicle bone graft (QF-MPBG). The aim of this study was to investigate the effects of CD and QF-MPBG on the patients with nontraumatic ONFH in an early stage. MATERIALS AND METHODS: 39 patients (47 hips) with ONFH in an early stage (Ficat Stage I or II) were randomly divided into two groups according to random number table method...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27903592/alpha-angle-measurements-in-healthy-adult-volunteers-vary-depending-on-the-mri-plane-acquisition-used
#16
Mohammad Golfam, Luigia A Di Primio, Paul E Beaulé, Kalesha Hack, Mark E Schweitzer
BACKGROUND: It has been shown that cam deformities are located at a more anterosuperior location than was previously described. PURPOSE: To establish, in a large group of asymptomatic participants, the normative range of the alpha angle in the anterosuperior location in both the oblique axial and radial views of magnetic resonance imaging (MRI). STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: In 197 asymptomatic participants (394 asymptomatic hips) with a mean age of 29...
November 9, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27903522/dietary-patterns-explaining-differences-in-bone-mineral-density-and-hip-structure-in-the-elderly-the-rotterdam-study
#17
Ester Al de Jonge, Jessica C Kiefte-de Jong, Albert Hofman, André G Uitterlinden, Brenda Ct Kieboom, Trudy Voortman, Oscar H Franco, Fernando Rivadeneira
BACKGROUND: Evidence on the association between dietary patterns, measures of hip bone geometry, and subsequent fracture risk are scarce. OBJECTIVE: The objective of this study was to evaluate whether dietary patterns that explain most variation in bone mineral density (BMD) and hip bone geometry are associated with fracture risk. DESIGN: We included 4028 subjects aged ≥55 y from the Rotterdam study. Intake of 28 food groups was assessed with the use of food-frequency questionnaires...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27903506/is-the-hip-capsule-thicker-in-diseased-hips
#18
K S Rakhra, A A Bonura, R Nairn, M E Schweitzer, N M Kolanko, P E Beaule
OBJECTIVES: The purpose of this study was to compare the thickness of the hip capsule in patients with surgical hip disease, either with cam-femoroacetabular impingement (FAI) or non-FAI hip pathology, with that of asymptomatic control hips. METHODS: A total of 56 hips in 55 patients underwent a 3Tesla MRI of the hip. These included 40 patients with 41 hips with arthroscopically proven hip disease (16 with cam-FAI; nine men, seven women; mean age 39 years, 22 to 58) and 25 with non-FAI chondrolabral pathology (four men, 21 women; mean age 40 years, 18 to 63) as well as 15 asymptomatic volunteers, whose hips served as controls (ten men, five women; mean age 62 years, 33 to 77)...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27903504/hip-pain-in-a-middle-aged-woman
#19
James S B Kho, David C Howlett
No abstract text is available yet for this article.
November 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27903480/long-term-outcomes-of-common-femoral-artery-stenting
#20
Bahaa Nasr, Adrien Kaladji, Pierre-Alexandre Vent, Philippe Chaillou, Alain Costargent, Thibault Quillard, Yann Gouëffic
OBJECTIVES: The purpose of this study was to report the 5-years outcome relative to endovascular repair of the common femoral artery for occlusive disease. MATERIALS/METHODS: 36 consecutive patients (40 limbs) underwent stenting for common femoral artery lesions. Patients were followed up systematically within a prospectively maintained database over 5 years. Follow-up included clinical examination, duplex scan and biplane x-ray at 1, 6, 12 months and yearly thereafter...
November 26, 2016: Annals of Vascular Surgery
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