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https://www.readbyqxmd.com/read/28828004/feasibility-of-short-period-high-dose-intravenous-methylprednisolone-for-preventing-stricture-after-endoscopic-submucosal-dissection-for-esophageal-cancer-a-preliminary-study
#1
Jun Nakamura, Takuto Hikichi, Ko Watanabe, Masaki Sato, Katsutoshi Obara, Hiromasa Ohira
OBJECTIVE: A wide mucosal defect after endoscopic submucosal dissection (ESD) for esophageal cancer is associated with increased risk of stricture. This study was conducted to evaluate the feasibility of short-period, high-dose intravenous methylprednisolone administration (steroid pulse therapy) in preventing post-ESD esophageal stricture. METHODS: This prospective study examined 13 lesions in 11 consecutive patients with esophageal squamous cell carcinoma who underwent ESD that involved three-quarters or more of the circumference of the esophagus or who had a longitudinal resected specimen diameter of ≥5 cm...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28827050/initial-experience-with-peroral-endoscopic-myotomy-for-treatment-of-achalasia-in-children
#2
William C Kethman, Chad M Thorson, Tiffany J Sinclair, William E Berquist, Stephanie D Chao, James K Wall
BACKGROUND: Achalasia is a primary esophageal motility disorder characterized by aperistalsis of the esophagus and failed relaxation of the lower esophageal sphincter that presents rarely in childhood. The peroral endoscopic myotomy (POEM) procedure is an emerging treatment for achalasia in adults that has recently been introduced into pediatric surgical practice. METHODS: This is a prospective case series of all children referred to Stanford University Lucile Packard Children's Hospital with manometry-confirmed achalasia who underwent a POEM procedure from 2014 to 2016...
August 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28822392/optimal-modified-frailty-index-cutoff-in-older-gastrointestinal-cancer-patients
#3
Mary Garland, Fang-Chi Hsu, Perry Shen, Clancy J Clark
The newly characterized modified frailty index (mFI) is a robust predictor of postoperative outcomes for surgical patients. The present study investigates the optimal cutoff for mFI specifically in older gastrointestinal (GI) cancer patients undergoing surgery. All patients more than 60 years old who underwent surgery for a GI malignancy (esophagus, stomach, colon, rectum, pancreas, liver, and bile duct) were identified in the 2005 to 2012 National Surgical Quality Improvement Program, Participant Use Data File (NSQIP PUF)...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28815221/a-modified-efficient-purse-string-stapling-technique-mest-that-uses-a-new-metal-rod-for-intracorporeal-esophagojejunostomy-in-laparoscopic-total-gastrectomy
#4
REVIEW
Takeshi Omori, Jeong-Ho Moon, Kazuyoshi Yamamoto, Yoshitomo Yanagimoto, Keijirou Sugimura, Hiroshi Miyata, Masahiko Yano, Masato Sakon
Intracorporeal esophagojejunostomy after laparoscopic total gastrectomy is technically difficult because this procedure should be performed in a narrow surgical field in the upper abdomen even when completely laparoscopic approaches are used. The placement of the anvil of a circular stapling device into the esophagus and connection the instrument to the anvil are extremely difficult steps in this surgery. Therefore, we developed a simple technique for intracorporeal esophagojejunostomy using hemi-double stapling technique; we named this technique the efficient purse-string stapling technique (EST)...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28815068/pattern-of-lymph-node-metastases-of-squamous-cell-esophageal-cancer-based-on-the-anatomical-lymphatic-drainage-system-efficacy-of-lymph-node-dissection-according-to-tumor-location
#5
REVIEW
Yuji Tachimori
Knowing the anatomical lymphatic drainage of the esophagus is crucial to understanding the dissemination pattern of esophageal tumor. During the embryonal growth, the middle and lower part of the esophagus stretches as the lymphatic networks develop in the submucosal layer. The abundant submucosal lymphatics drain in a longitudinal fashion directly to their proximal and distal ends. The lymphatic route from the proximal esophagus through recurrent nerve nodes to supraclavicular nodes are a component of the mesentery of the proximal esophagus...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28811720/endoscopic-occlusion-with-silicone-spigots-for-the-closure-of-refractory-esophago-bronchiole-fistula-after-esophagectomy
#6
Masaya Uesato, Tsuguaki Kono, Yasunori Akutsu, Kentarou Murakami, Akiko Kagaya, Yorihiko Muto, Akira Nakano, Mizuho Aikawa, Tomohide Tamachi, Hiroyuki Amagai, Takahiro Arasawa, Yasuhide Muto, Hisahiro Matsubara
A 65-year-old man with cT1bN0M0 stage I middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred, but it spontaneously improved. At six months after the operation, he was rehospitalized with a cough and dysphagia. An esophago-bronchiole fistula and stenosis of the gastric tube were observed. He first underwent stent placement in the gastric tube...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28807249/current-trends-in-multimodality-treatment-of-esophageal-and-gastroesophageal-junction-cancer-review-article
#7
REVIEW
Fredrik Klevebro, Simon Ekman, Magnus Nilsson
PURPOSE: Multimodality treatment has now been widely introduced in the curatively intended treatment of esophageal and gastroesophageal junction cancer. We aim to give an overview of the scientific evidence for the available treatment strategies and to describe which trends that are currently developing. METHODS: We conducted a review of the scientific evidence for the different curatively intended treatment strategies that are available today. Relevant articles of randomized controlled trials, cohort studies, and meta analyses were included...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28790241/-amyloidoma-adjacent-to-the-thoracic-vertebral-body-developed-into-systemic-amyloid-light-chain-amyloidosis
#8
Kyoko Tanaka, Hideto Goto, Shuhei Ikeda, Nami Masumoto, Katsuya Watanabe, Motofumi Tsubakihara
Amyloidoma is very rare case of amyloidosis, and seldom develop into systemic disease. We report a case of an 82-year-old man who was referred to our hospital because of an oppressive feeling in the upper chest. Chest computed tomography showed a tumor on thoracic vertebral body. Percutaneous needle biopsy showed pathological findings of AL amyloidosis. No obvious systemic finding was confirmed, and the tumor was diagnosed as amyloidoma. After a 1-year observation, heart amyloidosis was appeared, then 6 months later he died...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28781311/a-retrospective-study-an-initial-lesion-of-primary-malignant-melanoma-of-the-esophagus-revealed-by-endoscopy
#9
Sho Fukuda, Hirotaka Ito, Reina Ohba, Yuichirou Sato, Motoki Ohyauchi, Takehiko Igarashi, Nobuya Obana, Katsunori Iijima
A 66-year-old man presented to his previous physician with epigastric discomfort in 2014. He was then referred to our hospital due to suspected primary malignant melanoma of the esophagus (PMME). A biopsy showed atypical cells containing melanin granules. A diagnosis of PMME was thus made. We investigated the endoscopic findings of the previous physician, which revealed a black point-like pigmentation at the same site since 2009. In 2010, black pigmentation was also observed at the same site. Although esophageal melanosis was suspected, no biopsy was performed...
August 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28777465/basal-progenitor-cells-bridge-the-development-malignant-cancers-and-multiple-diseases-of-esophagus
#10
REVIEW
Baoshun Lin, Fuan Xie, Zhangwu Xiao, Xiaoqian Hong, Liming Tian, Kuancan Liu
The esophagus is a pivotal organ originating from anterior foregut that links the mouth and stomach. Moreover, its development involves precise regulation of multiple signal molecules and signal transduction pathways. After abnormal regulation of these molecules in the basal cells of the esophagus occurs, multiple diseases, including esophageal atresia with or without tracheoesophageal fistula, Barrett esophagus, gastroesophageal reflux, and eosinophilic esophagitis, will take place as a result. Furthermore, expression changes of signal molecules or signal pathways in basal cells and the microenvironment around basal cells both can initiate the switch of malignant transformation...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28771997/epac1-pde4-and-pkc-protein-expression-and-their-correlation-with-akap95-and-cx43-in-esophagus-cancer-tissues
#11
Zhiyu Guan, Winxin Zhuang, Hui Lei, Dai Wang, Youliang Yao, Dongbei Guo, Qian Sun, Yun Chen, Xiaoyi Chen, Hongyan Lin, Bogang Teng, Yongxing Zhang
BACKGROUND: This study examined the expression of exchange protein directly activated by cAMP1 (Epac1), PDE4, and PKC in esophageal cancer tissues, and analyzed the association of each protein with the pathological parameters of the samples. METHODS: Epac1, PDE4, and PKC protein expression was evaluated by PV-9000 two-step immunohistochemical techniques in 51 esophageal cancer specimens and 10 para-carcinoma tissues. RESULTS: The positive expression rates of Epac1 and PKC in esophageal cancer tissues (62...
August 3, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28770555/efficacy-of-liquid-nitrogen-cryotherapy-for-barrett-s-esophagus-after-endoscopic-resection-of-intramucosal-cancer-a-multicenter-study
#12
Arvind J Trindade, Douglas K Pleskow, Neil Sengupta, Shivangi Kothari, Sumant Inamdar, Joshua Berkowitz, Vivek Kaul
BACKGROUND AND AIM: Liquid nitrogen cryotherapy (LNC) allows increased depth of ablation compared to radiofrequency ablation (RFA) in Barrett's esophagus (BE). Expert centers may use LNC over RFA to ablate Barrett's esophagus after endoscopic resection of intramucosal cancer (IMCA). The aim of our study was to: 1) evaluate the safety and efficacy of LNC ablation in patients with BE and IMCA and 2) to evaluate the progression to invasive disease despite therapy. METHODS: This was a multicenter, retrospective study of consecutive patients with BE who received LNC following endoscopic mucosal resection (EMR) of IMCA...
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28769580/esophageal-motility-after-laparoscopic-sleeve-gastrectomy
#13
Eleni Sioka, George Tzovaras, Fotios Tsiopoulos, Dimitris Papamargaritis, Spyros Potamianos, Constantine Chatzitheofilou, Dimitris Zacharoulis
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) modifies the upper gastrointestinal tract motility. Controversial data currently exist. The aim of the study was to evaluate esophageal motility before and after LSG. PATIENTS AND METHODS: Morbid obese patients scheduled for LSG underwent reflux symptoms evaluation and manometry preoperatively and postoperatively. The preoperative and postoperative results were compared and analyzed. RESULTS: Eighteen patients were enrolled...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28768960/circumferential-locations-of-different-shapes-of-short-segment-barrett-s-esophagus
#14
Kyoichi Adachi, Tomoko Mishiro, Shino Tanaka, Yoshikazu Kinoshita
Objective To clarify the relationship between the shape and circumferential location of non-circumferential short-segment Barrett's esophagus (SSBE). Methods We examined 3,788 subjects (2,497 males, 1,291 females; mean age 52.4 years) who underwent upper GI endoscopy as part of a detailed medical checkup. The presence of columnar-appearing mucosa ≥10 mm long in the distal esophagus was diagnosed as BE and then divided into circumferential and non-circumferential localized types. Localized SSBE was further divided into round and sharp types based on the shape of the proximal margin...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28767597/comparison-of-imrt-versus-3d-crt-in-the-treatment-of-esophagus-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Dandan Xu, Guowen Li, Hongfei Li, Fei Jia
BACKGROUND: Esophageal cancer (EC) is a common cancer with high mortality because of its rapid progression and poor prognosis. Radiotherapy is one of the most effective treatments for EC. Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) are 2 recently developed radiotherapy techniques. IMRT is believed to be more effective than 3D-CRT in target coverage, dose homogeneity, and reducing toxicity to normal organs. However, these advantages have not been demonstrated in the treatment of EC...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766752/unlocking-opportunities-in-food-design-for-infants-children-and-the-elderly-understanding-milestones-in-chewing-and-swallowing-across-the-lifespan-for-new-innovations
#16
REVIEW
Julie A Y Cichero
Intake of a variety of foods increases the likelihood of good general health. From as early as life in utero, humans are exposed to flavor. Further flavor imprinting occurs via breast milk, increasing the likelihood of acceptance of a variety flavors when solids are introduced. While first foods need to be smooth and runny, experience managing soft lumps is required for rudimentary development of chewing skills. Texture experiences are critical to providing building blocks for food acceptance and gradual increase in the range of food textures eaten...
August 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28762451/esophageal-button-battery-ingestion-in-children
#17
Arzu Şencan, İncinur Genişol, Münevver Hoşgör
BACKGROUND: Button battery lodged in the esophagus carries a high risk of morbidity and mortality. The purpose of this study was to present cases of patients with esophageal button battery ingestion treated at our clinic and to emphasize the importance of early diagnosis and treatment. METHODS: Records of patients admitted to our hospital for foreign body ingestion between January 2010 and May 2015 were retrospectively reviewed. Cases with button battery lodged in the esophagus were included in the study...
July 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28761970/-feeding-eating-and-swallowing-disorders-in-infants-and-children-an-overview
#18
REVIEW
C Schwemmle, C Arens
Swallowing is a dynamic process that requires more than 30 muscles in the recruitment/coordination of the lips, tongue, palate, pharynx, larynx and esophagus. The eating and swallowing procedure is learned in sensitive or critical periods: when a certain degree of maturation has been achieved, the appropriate stimulus permits a certain milestone of development to occur. The swallowing procedure occurs in three main stages oral, pharyngeal, and esophageal. Therefore, swallowing disorders may present in any, some, or all of these stages in addition to feeding problems...
July 31, 2017: HNO
https://www.readbyqxmd.com/read/28758209/distinct-projection-targets-define-subpopulations-of-mouse-brainstem-vagal-neurons-that-express-the-autism-associated-met-receptor-tyrosine-kinase
#19
Anna Kamitakahara, Hsiao-Huei Wu, Pat Levitt
Detailed anatomical tracing and mapping of the viscerotopic organization of the vagal motor nuclei has provided insight into autonomic function in health and disease. To further define specific cellular identities, we paired information based on visceral connectivity with a cell-type specific marker of a subpopulation of neurons in the dorsal motor nucleus of the vagus (DMV) and nucleus ambiguus (nAmb) that express the autism-associated MET receptor tyrosine kinase. As gastrointestinal disturbances are common in children with autism spectrum disorder (ASD), we sought to define the relationship between MET-expressing (MET+) neurons in the DMV and nAmb, and the gastrointestinal tract...
July 31, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28754091/-visually-impaired-elderly-patient-ingests-pill-desiccant-leading-to-acute-hypoxic-respiratory-failure-requiring-intubation
#20
Wendy Gerstein, Ziyang Liu
BACKGROUND: A significant percentage of elderly patients suffer from both polypharmacy and visual impairment. This combination can increase the risk of an adverse event related to medication. This case highlights an unusual, but potentially deadly, medication adverse event. CASE PRESENTATION: A 77-year-old male, visually impaired, ingested a pill desiccant, believing it was the ampicillin/sulbactam tablet he was prescribed for an infected diabetic foot ulcer. He presented to the emergency room with inability to swallow, and imaging revealed the pill desiccant lodged in his upper esophagus...
July 28, 2017: BMC Geriatrics
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