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https://www.readbyqxmd.com/read/28067671/a-fatal-case-of-coin-battery-ingestion-in-an-18-month-old-child-case-report-and-literature-review
#1
Francesco Ventura, Sara Candosin, Rosario Barranco, Alessandro Bonsignore, Luisa Andrello, Luca Tajana, Antonio Osculati
The ingestion of extraneous substances is quite common in clinical practice; it usually befalls in the pediatric age, mostly between 6 months and 6 years. In most cases, complications do not emerge, and the prognosis is considered favorable. However, when a case of battery ingestion occurs, serious adverse events may develop. The ingestion of these components is a potential life-threatening event for children.In this article, we report the case of an 18-month-old child who died from hemorrhagic shock due to an aortoesophageal fistula caused by a 20 mm lithium button battery lodged in the esophagus...
January 7, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28062361/redox-signaling-in-the-gastrointestinal-tract
#2
REVIEW
Salvador Pérez, Raquel Taléns-Visconti, Sergio Rius-Pérez, Isabela Finamor, Juan Sastre
Redox signaling regulates physiological self-renewal, proliferation, migration and differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs). In the intestine, intracellular and extracellular thiol redox status modulates the proliferative potential of epithelial cells. Furthermore, commensal bacteria contribute to intestine epithelial homeostasis through NOX1- and dual oxidase 2-derived reactive oxygen species (ROS). The loss of redox homeostasis is involved in the pathogenesis and development of a wide diversity of gastrointestinal disorders, such as Barrett's esophagus, esophageal adenocarcinoma, peptic ulcer, gastric cancer, ischemic intestinal injury, celiac disease, inflammatory bowel disease and colorectal cancer...
January 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28060119/acquired-tef-in-hodgkin-lymphoma-in-a-child-a-rare-clinical-association
#3
Vinay Munikoty, Anmol Bhatia, Deepak Bansal, Ashim Das, Niranjan Khandelwal
BACKGROUND: Malignancy is the most common etiology of acquired fistulae between the tracheobronchial tree and esophagus. The majority are due to either primary bronchial or esophageal carcinoma, and are typically observed in adult population. The occurrence of tracheoesophageal fistula (TEF) in patients with Hodgkin lymphoma is a rare phenomenon. OBSERVATION: We report a rare case of Hodgkin lymphoma with TEF in a 10-year-old girl at presentation. She also developed pulmonary tuberculosis later during the follow up...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28054280/successful-bypass-operation-for-esophageal-obstruction-after-acute-esophageal-necrosis-a-case-report
#4
Yayoi Sakatoku, Masahide Fukaya, Kazushi Miyata, Masato Nagino
BACKGROUND: Acute esophageal necrosis (AEN) is a rare clinical disorder. Esophageal stenosis or obstruction is one of severe complications, but there are a few reports about surgical treatments. In such a situation, it still remains controversial which to choose, esophagectomy or bypass operation. CASE PRESENTATION: A 61-year-old woman was admitted to the local hospital for septic shock with diabetic ketoacidosis due to necrotizing fasciitis of the right thigh. Three days later, she had hematemesis, and gastrointestinal endoscopy revealed black mucosal coloration throughout the entire esophagus...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28049580/epigenetic-regulation-on-the-gene-expression-signature-in-esophagus-adenocarcinoma
#5
Ting Xi, Guizhi Zhang
BACKGROUND: Understanding the molecular mechanisms represents an important step in the development of diagnostic and therapeutic measures of esophagus adenocarcinoma (NOS). The objective of this study is to identify the epigenetic regulation on gene expression in NOS, shedding light on the molecular mechanisms of NOS. METHODS: In this study, 78 patients with NOS were included and the data of mRNA, miRNA and DNA methylation of were downloaded from The Cancer Genome Atlas (TCGA)...
December 19, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28048568/th-ab-207a-02-do-low-kvp-ct-scans-increase-the-dose-received-by-superficial-organs
#6
X Li, F Dong, A Primak, P Segars, B Herts
PURPOSE: Tube voltages below 120 kVp are increasingly used in clinical CT. There are concerns that dose to superficial organs such as skin, thyroid, and breasts may be elevated at a low-kVp setting. Our purpose was to investigate the effect of low-kVp imaging on the dose received by deep-seated and superficial organs as well as the effective dose. METHODS: Three computational patient models were included. They represented normal-weight, overweight, and obese adult females (BMI: 20-42)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048528/we-h-206-01-photoacoustic-tomography-multiscale-imaging-from-organelles-to-patients-by-ultrasonically-beating-the-optical-diffusion-limit
#7
L Wang
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048155/th-ef-brb-04-4%C3%AF-dynamic-conformal-arc-therapy-dynamic-conformal-arc-therapy-dcat-for-sbrt
#8
T Chiu, T Long, A Modiri, Z Tian, A Sawant, Y Yan, S Jiang, X Gu
PURPOSE: To develop an efficient and effective trajectory optimization methodology for 4π dynamic conformal arc treatment (4π DCAT) with synchronized gantry and couch motion; and to investigate potential clinical benefits for stereotactic body radiation therapy (SBRT) to breast, lung, liver and spine tumors. METHODS: The entire optimization framework for 4π DCAT inverse planning consists of two parts: 1) integer programming algorithm and 2) particle swarm optimization (PSO) algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048063/su-f-j-85-evaluation-of-the-velocity-deformable-image-registration-algorithm
#9
D Polan, J Kamp, J Y Lee, C Chapman, M Green, S Payal, M Kessler, K Brock
PURPOSE: To perform validation and commissioning of a commercial deformable image registration (DIR) algorithm (Velocity, Varian Medical Systems) for numerous clinical sites using single and multi-modality images. METHODS: In this retrospective study, the DIR algorithm was evaluated for 10 patients in each of the following body sites: head and neck (HN), prostate, liver, and gynecological (GYN). HN DIRs were evaluated from planning (p)CT to re-pCT and pCTs to daily CBCTs using dice similarity coefficients (DSC) of corresponding anatomical structures...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048061/mo-fg-campus-jep2-01-4d-mri-with-3d-radial-sampling-and-self-gating-based-k-space-sorting-image-quality-improvement-by-slab-selective-excitation
#10
Z Deng, W Yang, J Pang, R Tuli, X Bi, B Hakimian, B Fraass, D Li, Z Fan
PURPOSE: A recent 4D MRI technique based on 3D radial sampling and self-gating-based K-space sorting has shown promising results in characterizing respiratory motion. However due to continuous acquisition and potentially drastic k-space undersampling resultant images could suffer from low blood-to-tissue contrast and streaking artifacts. In this study 3D radial sampling with slab-selective excitation (SS) was proposed in attempt to enhance blood-to-tissue contrast by exploiting the in-flow effect and to suppress the excess signal from the peripheral structures particularly in the superior-inferior direction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047996/su-f-t-134-can-we-use-the-same-dose-constrains-learnt-from-photon-world-to-plan-proton-for-lung-cancer
#11
Z Xiao, J Zou, N Yue, M Zhang
PURPOSE: To evaluate if the same DVH constrains used in photon plans can be safely used to plan proton therapy for lung cancer. Since protons and photons have different dose deposition patterns, the hypothesis is following DVH constrains derived from photon world is not safe for proton. METHODS: We retrospectively evaluated plans for 11 lung cancer patients. Each patient was planned with photon and proton following the same dose constrains. Dose statistics on PTV, normal lung, heart and esophagus were extracted for comparison...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047869/we-h-206-02-recent-advances-in-multi-modality-molecular-imaging-of-small-animals
#12
B Tsui
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047753/su-d-204-01-a-methodology-based-on-machine-learning-and-quantum-clustering-to-predict-lung-sbrt-dosimetric-endpoints-from-patient-specific-anatomic-features
#13
K Lafata, L Ren, Q Wu, C Kelsey, J Hong, J Cai, F Yin
PURPOSE: To develop a data-mining methodology based on quantum clustering and machine learning to predict expected dosimetric endpoints for lung SBRT applications based on patient-specific anatomic features. METHODS: Ninety-three patients who received lung SBRT at our clinic from 2011-2013 were retrospectively identified. Planning information was acquired for each patient, from which various features were extracted using in-house semi-automatic software. Anatomic features included tumor-to-OAR distances, tumor location, total-lung-volume, GTV and ITV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047380/tu-ab-bra-08-slice-by-slice-approach-to-quantifying-inter-fractional-organ-motion
#14
T Mazur, M Cardenas, H Li, S Mutic, J Bradley, C Tsien, O Green
PURPOSE: To demonstrate the feasibility of a rapid computational algorithm for generating esophageal margin expansions. METHODS: Inter-fraction MRI allows visualization of relative variations of the esophagus and other critical structures when compared to planning CT. We have developed a rapid computational method for quantifying this motion. CT simulation and on-treatment MR data sets of seven patients were obtained using a 0.3 T MR-guided RT system. Rigid registration guided by bony anatomy from the cricoid to the gastro-esophageal junction was used for transferring CT contours to MR volumes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047344/su-f-t-106-a-dosimetric-study-of-intensity-modulated-radiation-therapy-to-decrease-radiation-dose-to-the-thoracic-vertebral-bodies-in-patients-receiving-concurrent-chemoradiation-for-lung-cancer
#15
Dominic DiCostanzo, Christian L Barney, Jose G Bazan
PURPOSE: Recent clinical studies have shown a correlation between radiation dose to the thoracic vertebral bodies (TVB) and the development of hematologic toxicity (HT) in patients receiving chemoradiation (CRT) for lung cancer (LuCa). The feasibility of a bone-marrow sparing (BMS) approach in this group of patients is unknown. We hypothesized that radiation dose to the TVB can be reduced with an intensity modulated radiation therapy(IMRT)/volumetric modulated arc radiotherapy(VMAT) without affecting plan quality...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047242/su-f-t-494-a-multi-institutional-study-of-independent-dose-verification-using-golden-beam-data
#16
M Itano, R Tachibana, M Yamashita, H Shimizu, Y Sugawara, K Kotabe, T Kamima, R Takahashi, S Ishibashi, Y Uchida, T Yamazaki, H Tachibana
PURPOSE: In general, beam data of individual linac is measured for independent dose verification software program and the verification is performed as a secondary check. In this study, independent dose verification using golden beam data was compared to that using individual linac's beam data. METHODS: Six institutions were participated and three different beam data were prepared. The one was individual measured data (Original Beam Data, OBD) .The others were generated by all measurements from same linac model (Model-GBD) and all linac models (All-GBD)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047205/we-h-206-03-promises-and-challenges-of-benchtop-x-ray-fluorescence-ct-xfct-for-quantitative-in-vivo-imaging
#17
S Cho
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046651/mo-fg-bra-08-swarm-intelligence-based-personalized-respiratory-gating-in-lung-sabr
#18
A Modiri, P Sabouri, X Gu, R Timmerman, A Sawant
PURPOSE: Respiratory gating is widely deployed as a clinical motion-management strategy in lung radiotherapy. In conventional gating, the beam is turned on during a pre-determined phase window; typically, around end-exhalation. In this work, we challenge the notion that end-exhalation is always the optimal gating phase. Specifically, we use a swarm-intelligence-based, inverse planning approach to determine the optimal respiratory phase and MU for each beam with respect to (i) the state of the anatomy at each phase and (ii) the time spent in that state, estimated from long-term monitoring of the patient's breathing motion...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046461/we-h-206-00-advances-in-preclinical-imaging
#19
Patrick La Riviere
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042239/oral-steroid-prophylaxis-is-effective-in-preventing-esophageal-strictures-after-large-endoscopic-resection
#20
Jean-Philippe Ratone, Erwan Bories, Fabrice Caillol, Christian Pesenti, Sebastien Godat, Flora Poizat, Chiara De Cassan, Marc Giovannini
BACKGROUND: Strictures are frequent complications of large endoscopic mucosal resections (EMR) and endoscopic submucosal dissections of the esophagus. Local or systemic steroid therapy has shown promise in the prevention of secondary stenosis. The aim of this study was to evaluate the safety and efficacy of systemic steroid therapy following endoscopic resection of at least hemi-circumferential esophageal mucosa. METHODS: This was a single-center retrospective study in a tertiary center...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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