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https://www.readbyqxmd.com/read/29930979/sirna-library-screening-identifies-a-druggable-immune-signature-driving-esophageal-adenocarcinoma-cell-growth
#1
Shane P Duggan, Catherine Garry, Fiona M Behan, Sinead Phipps, Hiromi Kudo, Murat Kirca, Abdul Zaheer, Sarah McGarrigle, John V Reynolds, Robert Goldin, Steve E Kalloger, David F Schaeffer, Aideen Long, Jessica Strid, Dermot Kelleher
Background & Aims: Effective therapeutic approaches are urgently required to tackle the alarmingly poor survival outcomes in esophageal adenocarcinoma (EAC) patients. EAC originates from within the intestinal-type metaplasia, Barrett's esophagus, a condition arising on a background of gastroesophageal reflux disease and associated inflammation. Methods: This study used a druggable genome small interfering RNA (siRNA) screening library of 6022 siRNAs in conjunction with bioinformatics platforms, genomic studies of EAC tissues, somatic variation data of EAC from The Cancer Genome Atlas data of EAC, and pathologic and functional studies to define novel EAC-associated, and targetable, immune factors...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29928869/focal-cryoballoon-versus-radiofrequency-ablation-of-dysplastic-barrett-s-esophagus-impact-on-treatment-response-and-postprocedural-pain
#2
Sanne N van Munster, Anouk Overwater, Rehan Haidry, Raf Bisschops, Jacques J G H M Bergman, Bas L A M Weusten
BACKGROUND AND AIMS: Radiofrequency ablation (RFA) is safe and effective for eradicating Barrett's esophagus (BE), but associated with significant postprocedural pain. Alternatively, balloon-based focal cryoablation (CRYO) has recently been developed, which preserves the extracellular matrix and might therefore be less painful. Although data for CRYO are still limited, uncontrolled studies suggest comparable safety and efficacy to RFA in eradicating limited BE areas. Therefore, secondary endpoints such as pain might become decisive for treatment selection...
June 18, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29928189/esophageal-large-cell-neuroendocrine-carcinoma-with-inconsistent-response-to-treatment-in-the-primary-and-metastatic-lesions
#3
Takashi Tomiyama, Masahiro Orino, Koh Nakamaru, Toshihiro Tanaka, Ryo Suzuki, Takashi Okazaki, Norimasa Fukata, Yugo Ando, Naoyuki Danbara, Toshiro Fukui, Chika Miyasaka, Kazuichi Okazaki
Esophageal large-cell neuroendocrine carcinoma (NEC) is a rare malignant tumor that is characterized by high-grade malignancy and a poor prognosis. However, the rarity of esophageal NEC has prevented the development of an established treatment, and no reports have described a discrepancy in the effectiveness of cisplatin plus irinotecan between primary and metastatic lesions. A 43-year-old Japanese man was referred to our hospital with refractory epigastralgia. A previous gastrointestinal endoscopy had revealed a 50-mm type 2 tumor in the abdominal esophagus...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29927863/endoscopic-esophageal-vacuum-therapy-a-novel-therapy-for-esophageal-perforations-in-pediatric-patients
#4
Michael A Manfredi, Susannah J Clark, Steven J Staffa, Peter D Ngo, C Jason Smithers, Thomas E Hamilton, Russell W Jennings
BACKGROUND: Esophageal perforation is a potentially life-threatening problem if not quickly diagnosed and treated appropriately. Negative pressure wound therapy (NPWT), commercially known as V.A.C.® therapy, was developed in the early 1990 s and is now standard of care for chronic surface wounds, ulcers, and burns. Adapting vacuum sponge therapy for use intraluminally for perforations of the esophagus was first reported in 2008. We report the first pediatric experience on a customized esophageal vacuum assisted closure (EVAC) device for closure of esophageal perforations...
June 20, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29927012/characteristics-of-atrial-fibrillation-patients-suffering-atrioesophageal-fistula-after-radiofrequency-catheter-ablation
#5
Yun Gi Kim, Jaemin Shim, Dong-Hyeok Kim, Jong-Il Choi, Sang-Weon Park, Hui-Nam Pak, Young-Hoon Kim
INTRODUCTION: Radiofrequency catheter ablation (RFCA) in atrial fibrillation (AF) patients can cause various complications and atrioesophageal (AE) fistula is one of the most catastrophic complications of RFCA. METHODS AND RESULTS: RFCA registries from 3 cardiovascular centers in Republic of Korea consisted of 5,721 patients undergoing 6,724 procedures. Before undergoing RFCA, patients underwent either computed tomography or magnetic resonance imaging. We evaluated clinical, anatomical, and procedural characteristics of patients who developed AE fistula after RFCA...
June 21, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29923024/newly-developed-magnifying-endoscopic-classification-of-the-japan-esophageal-society-to-identify-superficial-barrett-s-esophagus-related-neoplasms
#6
Kenichi Goda, Junko Fujisaki, Ryu Ishihara, Manabu Takeuchi, Akiko Takahashi, Yasuhiro Takaki, Dai Hirasawa, Kumiko Momma, Yuji Amano, Kazuyoshi Yagi, Hiroto Furuhashi, Tomoki Shimizu, Takashi Kanesaka, Satoru Hashimoto, Yoichiro Ono, Taku Yamagata, Junko Fujiwara, Takane Azumi, Masako Nishikawa, Gen Watanabe, Yasuo Ohkura, Tsuneo Oyama
AIM AND METHODS: The Japan Esophageal Society created a working committee group consisting of 11 expert endoscopists and 2 pathologists with expertise in Barrett's esophagus (BE) and esophageal adenocarcinoma. The group developed a consensus-based classification for the diagnosis of superficial BE-related neoplasms using magnifying endoscopy. RESULTS: The classification has three characteristics: simplified, an easily understood classification by incorporating the diagnostic criteria for the early gastric cancer, including the white zone and demarcation line, and the presence of a modified flat pattern corresponding to non-dysplastic histology by adding novel diagnostic criteria...
June 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29921284/atrial-fibrillation-after-transhiatal-esophagectomy-with-transcervical-endoscopic-esophageal-mobilization-one-institution-s-experience
#7
Elizabeth M Colwell, Carlos O Encarnacion, Lisa E Rein, Aniko Szabo, George Haasler, Mario Gasparri, William Tisol, David Johnstone
BACKGROUND: There have been numerous studies regarding atrial fibrillation (AF) associated with cardiac and pulmonary surgery; however, studies looking at esophagectomy and atrial fibrillation are sparse. The goal of this study was to review our institution's atrial fibrillation rate following esophagectomy in order to better define the incidence and predisposing factors in this patient population. METHODS: A retrospective chart review of all patients undergoing esophagectomy with transcervical endoscopic mobilization of the esophagus (TEEM) at the Medical College of Wisconsin and Affiliated Hospitals from July 2009 through December 2012...
June 19, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29920292/novel-tumor-necrosis-factor-%C3%AE-induced-protein-eight-tnfaip8-tipe-family-functions-and-downstream-targets-involved-in-cancer-progression
#8
Ganesan Padmavathi, Kishore Banik, Javadi Monisha, Devivasha Bordoloi, Shabnam Bano, Frank Arfuso, Gautam Sethi, Fan Lu, Ajaikumar B Kunnumakkara
The tumor necrosis factor (TNF)-α- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland...
June 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29913787/modality-specific-alterations-of-esophageal-sensitivity-caused-by-longstanding-diabetes-mellitus
#9
Jan Brun, Christina Brock, Jens B Frøkjær, Eirik Söfteland, Magnus Simrén, Hans Gregersen, Asbjørn M Drewes
Background Abnormal visceral sensory function has been demonstrated in patients with diabetes mellitus and diabetic autonomic neuropathy seems to be involved in the development and progression of gastrointestinal tract dysfunction. The possibility of multimodal (e.g. mechanical, electrical, thermal and chemical) stimulation in, e.g. the esophagus has developed visceral pain research. The major advantage is involvement of distinctive receptors, various sensory nerves and different pain pathways mimicking clinical pain that favours investigation of central pain mechanisms involved in allodynia and hyperalgesia...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909416/non-invasive-detection-of-anastomotic-leakage-following-esophageal-and-pancreatic-surgery-by-urinary-analysis
#10
Victor D Plat, Nora van Gaal, James A Covington, Matthew Neal, Tim G J de Meij, Donald L van der Peet, Babs Zonderhuis, Geert Kazemier, Nanne K H de Boer, Freek Daams
BACKGROUND: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL. Urinary volatile organic compounds (VOCs) reflect the metabolic status of an individual, which is associated with a systemic immunological response...
June 15, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29906417/selection-and-application-of-tissue-micrornas-for-non-endoscopic-diagnosis-of-barrett-s-esophagus
#11
Xiaodun Li, Sam Kleeman, Sally B Coburn, Carlo Fumagalli, Juliane Perner, Sriganesh Jammula, Ruth M Pfeiffer, Linda Orzolek, Haiping Hao, Philip R Taylor, Ahmad Miremadi, Núria Galeano-Dalmau, Pierre Lao-Sirieix, Maria Tennyson, Shona MacRae, Michael B Cook, Rebecca C Fitzgerald
BACKGROUND & AIMS: MicroRNA (miRNA) is highly stable in biospecimens and provides tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to discover a set of miRNAs that could accurately discriminate Barrett's esophagus (BE) from normal esophageal tissue and to test its diagnostic accuracy when applied to samples collected by a non-invasive esophageal cell sampling device. METHODS: We analyzed miRNA expression profiles of 2 independent sets of esophageal biopsy tissues collected during endoscopy from 38 patients with BE and 26 patients with normal esophagus (controls) using Agilent microarray and Nanostring counter assays...
June 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29905908/natural-history-of-barrett-s-esophagus
#12
REVIEW
Ernst J Kuipers, Manon C Spaander
Barrett's esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. The prevalence of BE increases with age both in men and in women. This increase starts at a younger age in men than in women. The incidence of high-grade dysplasia and cancer in BE depends on segment length, gender, and age...
June 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29905537/surgical-treatment-of-bening-esophageal-strictures-after-corrosive-injuries
#13
V Boyko, S Savvi, A Korolevska, V Zhydetskyy, Y Novikov, S Bytiak, D Shuba
The research is based on the results of the examination and treatment of 156 patients who received treatment for extended benign esophageal strictures after corrosive injuries in the department of diseases of the esophagus and the gastrointestinal tract of the State Institution "V. T. Zaitsev Institute of General and Urgent Surgery of NAMS of Ukraine" for the period from 2000 to 2016. Surgical treatment by the developed in our hospital technique performed in the patients of the main group and the classical methods of surgery were used in the patients of comparison group...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29902646/factors-associated-with-recurrence-of-barrett-s-esophagus-after-radiofrequency-ablation
#14
Mimi C Tan, Kavin A Kanthasamy, Allison G Yeh, Daniel Kil, Lisa Pompeii, Xiaoying Yu, Hashem B El-Serag, Aaron P Thrift
BACKGROUND & AIMS: Radiofrequency ablation (RFA) is effective treatment for Barrett's esophagus (BE). However, some patients have recurrence after complete eradication of intestinal metaplasia (CEIM). We investigated the incidence of and factors associated with BE recurrence, with or without neoplasia, after RFA and CEIM using data from the national Veterans Affairs (VA) healthcare system. METHODS: We performed a retrospective cohort study of Veterans with BE treated by RFA from 2005 through 2016 with follow-up endoscopy...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29888452/the-esophagiome-integrated-anatomical-mechanical-and-physiological-analysis-of-the-esophago-gastric-segment
#15
Jingbo Zhao, Barry McMahon, Mark Fox, Hans Gregersen
Esophageal diseases are highly prevalent and carry significant socioeconomic burden. Despite the apparently simple function of the esophagus, we still struggle to better understand its physiology and pathophysiology. The assessment of large data sets and application of multiscale mathematical organ models have gained attention as part of the Physiome Project. This has long been recognized in cardiology but has only recently gained attention for the gastrointestinal(GI) tract. The term "esophagiome" implies a holistic assessment of esophageal function, from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents...
June 10, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29881606/a-reduced-esophageal-epithelial-integrity-in-a-subgroup-of-healthy-individuals-increases-with-proton-pump-inhibitor-therapy
#16
Ans Pauwels, Charlotte Broers, Tim Vanuytsel, Nicolas Pardon, Silvia Cocca, Sabine Roman, Frank Zerbib, Jan Tack, Ricard Farré
Introduction: Approximately 30% of healthy volunteers (HVs) show dilated intercellular spaces in the esophageal epithelium suggesting a functionally reduced epithelial integrity. We aimed to evaluate the presence of an altered epithelial integrity in HVs and whether physiological acid could explain such a difference. Methods: Biopsies for Ussing chamber experiments were taken between 3 cm and 5 cm proximal to the gastroesophageal junction. Twenty-four-hour impedance-pH (MII-pH) monitoring was performed in the same 15 HVs...
May 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29877949/study-of-the-influence-of-heme-oxygenase-1-gene-single-nucleotide-polymorphism-rs2071746-on-esophageal-varices-among-patients-with-cirrhosis
#17
Walid Ismail Ellakany, Khaled Mahmoud MoheyEldin, Pietro Invernizzi, Ali Mahmoud ElKady, Hossam Eldin Fathy Abou Elkheir, Reham Abdel Haleem Abo Elwafa, Ahmed Ellakany
INTRODUCTION: Cirrhosis as a pathological term has some criteria known to be common in all cases of liver cirrhosis. Esophageal varices are portosystemic collaterals arising in the submucosa of the lower esophagus because of portal hypertension. Portal hypertension is defined as hepatic venous pressure gradient greater than 5 mmHg that arises often as a sequelae of mesenchymal dysfunction in a cirrhotic liver. This study was carried out on 120 personnel divided into three groups: group A included 50 cases of liver cirrhosis with esophageal varices, group B consisted of 50 cases of cirrhosis without esophageal varices, and group C had 20 healthy volunteers a control group...
June 5, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29876309/rationale-and-early-outcomes-for-the-management-of-thymoma-with-proton-therapy
#18
He J Zhu, Bradford S Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R Charles Nichols, Randal H Henderson, Catherine E Mercado
Background: Radiotherapy for thymic malignancies is technically challenging due to their close proximity to the heart, lungs, esophagus, and breasts, raising concerns about significant acute and late toxicities from conventional photon radiotherapy. Proton therapy (PT) may reduce the radiation dose to these vital organs, leading to less toxicity. We reviewed the dosimetry and outcomes among patients treated with PT for thymic malignancies at our institution. Methods: From January 2008 to March 2017, six patients with de novo Masaoka stages II-III thymic malignancies were treated with PT on an IRB-approved outcomes tracking protocol...
April 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29871822/the-lung-and-esophagus-developmental-and-regenerative-overlap
#19
REVIEW
Edward E Morrisey, Anil K Rustgi
Lung and esophageal development and organogenesis involve a complex interplay of signaling pathways and transcriptional factors. Once the lung and esophagus do separate, their epithelial proliferation and differentiation programs share certain common properties that may fuel adaptive responses to injury and subsequent regeneration. Lung and esophageal tissue organogenesis and regeneration provide perspectives on squamous cell cancers and adenocarcinomas in each tissue.
June 2, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29863149/robotic-surgery-for-esophageal-cancer-merits-and-demerits
#20
REVIEW
Yasuyuki Seto, Kazuhiko Mori, Susumu Aikou
Since the introduction of robotic systems in esophageal surgery in 2000, the number of robotic esophagectomies has been gradually increasing worldwide, although robot-assisted surgery is not yet regarded as standard treatment for esophageal cancer, because of its high cost and the paucity of high-level evidence. In 2016, more than 1800 cases were operated with robot assistance. Early results with small series demonstrated feasibility and safety in both robotic transhiatal (THE) and transthoracic esophagectomies (TTE)...
September 2017: Annals of gastroenterological surgery
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