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https://www.readbyqxmd.com/read/28342951/a-model-to-identify-individuals-at-high-risk-for-esophageal-squamous-cell-carcinoma-and-precancerous-lesions-in-regions-of-high-prevalence-in-china
#1
Mengfei Liu, Zhen Liu, Hong Cai, Chuanhai Guo, Xiang Li, Chaoting Zhang, Hui Wang, Dong Hang, Fangfang Liu, Qiuju Deng, Xin Yang, Wenqing Yuan, Yaqi Pan, Jingjing Li, Chanyuan Zhang, Na Shen, Zhonghu He, Yang Ke
BACKGROUND & AIMS: We aimed to develop a population-based model to identify individuals at high-risk for esophageal squamous cell carcinoma (ESCC) in regions of China with a high prevalence of this cancer. METHODS: We collected findings from 15,073 permanent residents (45-69 years old) of 334 randomly selected villages in Hua County, Henan Province, China who underwent endoscopic screening (with iodine staining) for ESCC from January 2012 through September 2015...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#2
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
Background The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. Methods Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. Results EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
March 24, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28337481/waterjet-submucosal-dissection-of-porcine-esophagus-with-the-hybridknife-and-erbejet-2-system-a-pilot-study
#3
Daisuke Akutsu, Hideo Suzuki, Toshiaki Narasaka, Masahiko Terasaki, Tsuyoshi Kaneko, Hirofumi Matsui, Yuji Mizokami, Ichinosuke Hyodo
Background and study aims Esophageal endoscopic submucosal dissection (ESD) is technically difficult because of narrow working spaces and ease of perforation due to the lack of serosa. HybridKnife is a recently developed ESD device that is combined with the high pressure waterjet ERBEJET 2 system to lift mucosa. We hypothesized that this waterjet could make submucosal dissection safer and studied this in porcine esophagus. Materials and methods Water pressures of 30 - 70 bar were tested to determine the appropriate pressure for waterjet ESD with HybridKnife (WJ-ESD) in one pig...
January 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28336546/barrett-s-metaplasia-develops-from-cellular-reprograming-of-esophageal-squamous-epithelium-due-to-gastroesophageal-reflux
#4
Carlos D Minacapelli, Manisha Bajpai, Xin Geng, Christina L Cheng, Abhishek A Chouthai, Rhonda F Souza, Stuart Jon Spechler, Kiron M Das
OBJECTIVE: Gastroesophageal reflux disease (GERD) clinically predisposes to columnar Barrett's metaplasia (BM) in the distal esophagus. We demonstrate evidence supporting cellular origin of BM from reprograming or trans-commitment of resident normal esophageal squamous (NES) epithelial cells in response to acid and bile exposure using an in vitro cell culture model. DESIGN: The hTERT-immortalized NES cell line, NES-B10T, was exposed 5 min/day to Acid and Bile (A+B) mixture for 30 weeks...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28334837/clinical-outcome-of-definitive-radiation-therapy-for-superficial-esophageal-cancer
#5
Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa
Objective: To analyze the clinical outcome of concurrent chemoradiotherapy in superficial esophageal cancer patients. Methods: We retrospectively analyzed data for 123 patients with superficial esophageal cancer who received external beam radiotherapy without intracavitary brachytherapy plus systemic chemotherapy during 1998-2015. Elective nodal irradiation was not performed. The dosage to planning treatment volume was 60 Gy in 30 fractions. The main outcome measure was overall survival...
February 23, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28333543/corrosive-induced-carcinoma-of-esophagus-esophagographic-and-ct-findings
#6
Seung Yeon Noh, Hyun Jin Kim, Hyun Joo Lee, Seong Ho Park, Jong Seok Lee, Ah Young Kim, Hyun Kwon Ha
OBJECTIVE: The purpose of this study was to evaluate the esophagographic and CT findings of corrosive esophageal cancer. MATERIALS AND METHODS: The records of all patients who presented with corrosive esophageal strictures at one institution between June 1989 and April 2015 were retrospectively identified. The search yielded the records of 15 patients with histopathologically proven esophageal cancer. Esophagograms (13 patients) and chest CT images (14 patients) were interpreted independently by two reviewers...
March 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28323577/mitigation-of-radiation-induced-epithelial-damage-by-the-tlr5-agonist-entolimod-in-a-mouse-model-of-fractionated-head-and-neck-irradiation
#7
Ilia A Toshkov, Anatoli S Gleiberman, Vadim L Mett, Alan D Hutson, Anurag K Singh, Andrei V Gudkov, Lyudmila G Burdelya
Radiation treatment of head and neck cancer frequently causes severe collateral damage to normal tissues including mouth mucosa, salivary glands and skin. This toxicity limits the radiation dose that can be delivered and affects the patient's quality of life. Previous studies in mice and nonhuman primates showed that entolimod, a toll-like receptor 5 (TLR5) agonist derived from bacterial flagellin, effectively reduced radiation damage to hematopoietic and gastrointestinal tissues in both total-body and local irradiation scenarios, with no protection of tumors...
March 21, 2017: Radiation Research
https://www.readbyqxmd.com/read/28322771/computer-aided-detection-of-early-barrett-s-neoplasia-using-volumetric-laser-endomicroscopy
#8
A Swager, F van der Sommen, S R Klomp, S Zinger, S L Meijer, E J Schoon, J J Bergman, P H N de With, W L Curvers
BACKGROUND AND AIMS: Volumetric laser endomicroscopy (VLE) is an advanced imaging system that provides a near-microscopic resolution scan of the esophageal wall layers up to 3 mm deep. VLE has the potential to improve detection of early neoplasia in Barrett's esophagus (BE). However, interpretation of VLE images is complex due to the large amount of data that needs to be interpreted in real-time. The aim of this study was to investigate the feasibility of a computer algorithm to identify early BE neoplasia on ex vivo VLE images...
March 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28317452/recent-advances-in-diagnostic-testing-for-gastroesophageal-reflux-disease
#9
Rishi D Naik, Michael F Vaezi
Gastroesophageal reflux disease (GERD) has a large economic burden with important complications that include esophagitis, Barrett's esophagus, and adenocarcinoma. Despite endoscopy, validated patient questionnaires, and traditional ambulatory pH monitoring, the diagnosis of GERD continues to be challenging. Areas covered: This review will explore the difficulties in diagnosing GERD with a focus on new developments, ranging from basic fundamental changes (histology and immunohistochemistry) to direct patient care (narrow-band imaging, impedance, and response to anti-reflux surgery)...
March 20, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28316321/analyzing-esophageal-squamous-cell-papillomas-for-the-presence-of-human-papilloma-virus
#10
Arzu Tiftikçi, Eser Kutsal, Ender Altıok, Ümit İnce, Bahattin Çicek, Murat Saruç, Nurten Türkel, Özdal Ersoy, Güven Yenmiş, Nurdan Tözün
BACKGROUND/AIMS: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV. MATERIALS AND METHODS: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals...
March 17, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28314877/fully-automated-vmat-treatment-planning-for-advanced-stage-nsclc-patients
#11
Giuseppe Della Gala, Maarten L P Dirkx, Nienke Hoekstra, Dennie Fransen, Nico Lanconelli, Marjan van de Pol, Ben J M Heijmen, Steven F Petit
PURPOSE: To develop a fully automated procedure for multicriterial volumetric modulated arc therapy (VMAT) treatment planning (autoVMAT) for stage III/IV non-small cell lung cancer (NSCLC) patients treated with curative intent. MATERIALS AND METHODS: After configuring the developed autoVMAT system for NSCLC, autoVMAT plans were compared with manually generated clinically delivered intensity-modulated radiotherapy (IMRT) plans for 41 patients. AutoVMAT plans were also compared to manually generated VMAT plans in the absence of time pressure...
March 17, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28301879/laparoscopic-transgastric-circumferential-stapler-assisted-vs-endoscopic-esophageal-mucosectomy-in-a-porcine-model
#12
Daniel C Steinemann, Andreas Zerz, Philip C Müller, Peter Sauer, Anja Schaible, Felix Lasitschka, Anne-Catherine Schwarz, Beat P Müller-Stich, Georg R Linke
Background and study aims Extensive endoscopic mucosal resection (EMR) for Barrett's esophagus (BE) may lead to stenosis. Laparoscopic, transgastric, stapler-assisted mucosectomy (SAM) with the retrieval of a circumferential specimen is proposed. Methods SAM was evaluated in two phases. The feasibility of SAM and the quality of specimens were assessed in eight animals. The mucosal healing was evaluated in a 6-week survival experiment comparing SAM (n = 6) with EMR (n = 6). The ratio of the esophageal lumen width (REL) at the resection level measured on fluoroscopy at 6 weeks divided by the width immediately after resection was compared...
March 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28297307/development-and-evaluation-of-a-clinical-model-for-lung-cancer-patients-using-stereotactic-body-radiotherapy-sbrt-within-a-knowledge-based-algorithm-for-treatment-planning
#13
Karen Chin Snyder, Jinkoo Kim, Anne Reding, Corey Fraser, James Gordon, Munther Ajlouni, Benjamin Movsas, Indrin J Chetty
The purpose of this study was to describe the development of a clinical model for lung cancer patients treated with stereotactic body radiotherapy (SBRT) within a knowledge-based algorithm for treatment planning, and to evaluate the model performance and applicability to different planning techniques, tumor locations, and beam arrangements. 105 SBRT plans for lung cancer patients previously treated at our institution were included in the development of the knowledge-based model (KBM). The KBM was trained with a combination of IMRT, VMAT, and 3D CRT techniques...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28276825/perioperative-chemotherapy-for-resectable-gastric-cancer-what-is-the-evidence
#14
Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
The UK MAGIC trial published in 2006 was the first RCT to identify improved long-term survival rates using preoperative chemotherapy for resectable gastric or gastroesophageal cancer. Overnight, the treatment regimen impacted European guidelines. However, the majority of patients underwent limited lymph node dissection, and analyses of the rates of curative resection, downsizing and downstaging were not by intention to treat, rightfully raising concerns about their validity. For the subset of true gastric cancers, meta-analyses may even question the claims of improved long-term survival rates by present-day regimens...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28274404/in-vivo-dosimetry-with-optically-stimulated-luminescent-dosimeters-for-conformal-and-intensity-modulated-radiation-therapy-a-2-year-multicenter-cohort-study
#15
Adam C Riegel, Yu Chen, Ajay Kapur, Laura Apicello, Abraham Kuruvilla, Anthony J Rea, Abolghassem Jamshidi, Louis Potters
PURPOSE: Optically stimulated luminescent dosimeters (OSLDs) are utilized for in vivo dosimetry (IVD) of modern radiation therapy techniques such as intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). Dosimetric precision achieved with conventional techniques may not be attainable. In this work, we measured accuracy and precision for a large sample of clinical OSLD-based IVD measurements. METHODS AND MATERIALS: Weekly IVD measurements were collected from 4 linear accelerators for 2 years and were expressed as percent differences from planned doses...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28272380/complexity-and-diversity-of-gerd-phenotypes
#16
Patrizia Zentilin, Elisa Marabotto, Gaia Pellegatta, Claudia Coppo, Manuele Furnari, Edoardo Savarino, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is defined as a condition which develops when the reflux of gastric contents causes troublesome symptoms, impairs quality of life, or leads to mucosal damage or complications. There are two main phenotypic presentations of GERD, the erosive (ERD) and non-erosive reflux disease (NERD), with the latter one representing up to 70% of GERD spectrum. Moreover, patients with GERD can be clinically subdivided into two distinct syndromes: patinets with esophageal and extraesophageal symptoms...
March 7, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28264215/prevention-of-esophageal-stricture-after-endoscopic-submucosal-dissection-using-rna-based-silencing-of-carbohydrate-sulfotransferase-15-in-a-porcine-model
#17
Hiroki Sato, Seiji Sagara, Nao Nakajima, Teppei Akimoto, Kenji Suzuki, Hiroyuki Yoneyama, Shuji Terai, Naohisa Yahagi
Background and study aims Endoscopic submucosal dissection (ESD) for esophageal carcinoma frequently causes fibrotic strictures that require treatment. A possible preventive effect of small interfering RNA (siRNA) targeting carbohydrate sulfotransferase 15 (CHST15) on esophageal stricture formation after ESD was investigated in 3 pigs. Materials and methods Two half-circumferential ESD ulcers were created in the oral and anal ends of the esophagus. CHST15 siRNA was injected submucosally in one of the two ESD ulcers...
March 6, 2017: Endoscopy
https://www.readbyqxmd.com/read/28263955/pathway-cross-talk-analysis-in-detecting-significant-pathways-in-barrett-s-esophagus-patients
#18
Zhengyuan Xu, Yan Yan, Jian He, Xinfang Shan, Weiguo Wu
BACKGROUND The pathological mechanism of Barrett's esophagus (BE) is still unclear. In the present study, pathway cross-talks were analyzed to identify hub pathways for BE, with the purpose of finding an efficient and cost-effective detection method to discover BE at its early stage and take steps to prevent its progression. MATERIAL AND METHODS We collected and preprocessed gene expression profile data, original pathway data, and protein-protein interaction (PPI) data. Then, we constructed a background pathway cross-talk network (BPCN) based on the original pathway data and PPI data, and a disease pathway cross-talk network (DPCN) based on the differential pathways between the PPI data and the BE and normal control...
March 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28260354/overlap-of-gerd-and-gastrointestinal-functional-disorders
#19
Nicola De Bortoli, Veronica Natali, Sara Melissari, Natalia Simonetti, Gherardo Tapete, Santino Marchi
The functional gastrointestinal disorders (FGIDs) are common conditions with an overall prevalence burden estimated at approximately one-third of the population. These represent a heterogeneous group of conditions which may include both abnormal symptom perception and functional causes and seems to share similar trigger factors as food, lifestyle and psychological factor. GERD develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms, with or without mucosal involvement. Functional heartburn represents a subcategory of patients who refers with heartburn but without abnormal esophageal acid exposure, abnormal number of reflux events or any temporal correlation between symptoms and reflux events, on the same hands these patients do not report any symptom relief during antisecretory treatment with proton pump inhibitors...
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28260353/is-there-a-role-for-high-resolution-manometry-in-gerd-diagnosis
#20
Salvatore Tolone, Edoardo Savarino, Ludovico Docimo
Gastroesophageal reflux disease (GERD) is a condition, which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. In patients with alarm symptoms or signs or in those refractory to antiacid therapy, it is indicated to perform instrumental tests to correctly diagnose GERD presence. Esophageal manometry is currently considered the gold standard test for the diagnosis of esophageal dysmotility. However, it has shown limited capability in diagnosing GERD. With the advent of high resolution manometry (HRM), more accurate evaluations of esophageal motility are now possible...
March 3, 2017: Minerva Gastroenterologica e Dietologica
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