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https://www.readbyqxmd.com/read/29667441/long-term-consumption-of-western-diet-contributes-to-endothelial-dysfunction-and-aortic-remodeling-in-rats-implication-of-rho-kinase-signaling
#1
Rania A Elrashidy, Jing Zhang, Guiming Liu
Western diet (WD), rich in saturated fat and sugars, has become a risk factor for obesity and metabolic syndrome, however, its effect on endothelial function and vascular remodeling is not fully elucidated. Recent evidence suggests cross-talk between Rho kinase (ROCK) pathway and cardiovascular system. We aimed to investigate the effect of WD on aortic remodeling and the contribution of ROCK signaling. Eight week old male Sprague-Dawley rats were fed either standard chow diet (SD) or high fructose/ high-fat diet, typically as in WD...
April 18, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29662662/health-effects-of-a-forest-environment-on-natural-killer-cells-in-humans-an-observational-pilot-study
#2
Tsung-Ming Tsao, Ming-Jer Tsai, Jing-Shiang Hwang, Wen-Fang Cheng, Chang-Fu Wu, Charles-C K Chou, Ta-Chen Su
Health effect assessments based on natural killer (NK) cells are an important emerging area of human health. We recruited 90 forest staff members in Xitou, Taiwan and 110 urban staff members in Taipei to investigate the health effects of forest environment exposure on NK cells (CD3- /CD56+ ) and activating NK cells (CD3- /CD56+ /CD69+ ) in humans. We also invited 11 middle-aged volunteers in a pilot study to participate in a five-day/four-night forest trip to Xitou forest to investigate the health effects of a forest trip on NK cells and activating NK cells...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643115/chronic-at1-blockade-improves-glucose-homeostasis-in-obese-oletf-rats
#3
Ruben Rodriguez, Jacqueline N Minas, Jose Pablo Vazquez-Medina, Daisuke Nakano, David G Parkes, A Nishiyama, Rudy M Ortiz
Obesity is associated with the inappropriate activation of the renin-angiotensin-system (RAS), which increases arterial pressure, impairs insulin secretion, and decreases peripheral tissue insulin sensitivity. RAS blockade reverses these detriments; however, it is not clear whether the disease state of the organism and treatment duration determine the beneficial effects of RAS inhibition on insulin secretion and insulin sensitivity. Therefore, the objective of this study was to compare the benefits of acute vs...
April 11, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29642917/gender-specific-association-of-serum-uric-acid-levels-and-cardio-ankle-vascular-index-in-chinese-adults
#4
Xiaoya Zheng, Qiang Wei, Jian Long, Lilin Gong, Hua Chen, Rong Luo, Wei Ren, Yonghong Wang
BACKGROUND: Little is known about the relationship between serum uric acid (SUA) and cardio-ankle vascular index (CAVI) in Chinese population. Therefore, we aimed to investigate the gender difference in the association of SUA and CAVI in a southwestern Chinese population. METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014 in Chongqing. The data included completed anthropometry and blood biochemical indicators...
April 11, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29629275/human-cd36-overexpression-in-renal-tubules-accelerates-the-progression-of-renal-diseases-in-a-mouse-model-of-folic-acid-induced-acute-kidney-injury
#5
Jong Hwan Jung, Jee Eun Choi, Ju Hung Song, Seon-Ho Ahn
Background: Acute kidney injury (AKI) is a risk factor for progression to chronic kidney disease, with even subclinical AKI episodes progressing to chronic kidney disease. Several risk factors such as preexisting kidney disease, hyperglycemia, and hypertension may aggravate renal disease after AKI. However, mechanisms underlying the progression of AKI are still unclear. This study identified the effect of human cluster of differentiation 36 (CD36) overexpression on the progression of folic acid-induced AKI...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29627992/beneficial-effect-of-the-sglt2-inhibitor-empagliflozin-on-glucose-homeostasis-and-cardiovascular-parameters-in-the-cohen-rosenthal-diabetic-hypertensive-crdh-rat
#6
Firas Younis, Jonathan Leor, Zaid Abassi, Natalie Landa, Lea Rath, Kenneth Hollander, Nili Naftali-Shani, Talma Rosenthal
The effectiveness of empagliflozin (EMPA), a sodium glucose cotransporter type 2 inhibitor, on the kidney, pancreas, and heart was investigated in the Cohen Rosenthal diabetic hypertensive rat model (CRDH rat). Six-week-old CRDH male rats were fed a sugar diet (SD) and treated with the compound EMPA (group Drug/SD) or respective comparator with vehicle (group Veh/SD). A control group was fed a regular diet without treatment (group Veh/P). Preventive treatment with EMPA was measured during 4 months of follow-up...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29625459/beyond-hyperglycemia-evidence-for-retinal-neurodegeneration-in-metabolic-syndrome
#7
Cagatay Karaca, Zuleyha Karaca
Purpose: We evaluated the retinal effects of systemic metabolic changes clustered under the umbrella of metabolic syndrome (MetS) in comparison with age-matched healthy subjects. Methods: Spectral-domain optical coherence tomography (OCT) retinal segmentation analysis of 29 patients with MetS and 36 control subjects was performed. Patients with diabetes mellitus (DM), uncontrolled hypertension, retinopathy, high myopia or hyperopia, and posterior segment surgery, were excluded from analysis...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623017/rising-incidence-of-obesity-in-saudi-residents-a-threatening-challenge-for-the-surgeons
#8
Azzam Al-Kadi, Arshad M Malik, Ali E Mansour
Objective: Obesity is thought to correlate very strongly with individuals general lifestyles. This study was conducted to determine whether lifestyle patterns were potential risk factors for morbid obesity in Saudi residents. Methods: This descriptive cross-sectional study was conducted in Unaizah City, Qassim Region, Kingdom of Saudi Arabia, over a 1-year period from March 2013 to March 2014. The study included 646 residents from the general public of Unaizah who were selected by convenient sampling at a mall and a public sector university, regardless of age and gender, and were given questionnaires regarding the details of their lifestyle patterns...
January 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29619091/dynamic-development-of-metabolic-syndrome-and-its-risk-prediction-in-chinese-population-a-longitudinal-study-using-markov-model
#9
Xiaoxian Jia, Qicai Chen, Peipei Wu, Meng Liu, Xiaoxiao Chen, Juan Xiao, Lili Chen, Pengpeng Zhang, Shumei Wang
Background: With the increasing prevalence of metabolic syndrome (MS), there is a need to track and predict the development of MS. In this study, we established a Markov model to explore the natural history and predict the risk of MS. Methods: A total of 21,777 Chinese individuals who had at least two consecutive health check-ups between 2010 and 2015 were studied. MS was defined using the Chinese Diabetes Society criteria. Twelve metabolic abnormal states (the no component state, four isolated component states, six 2-component states, and the MS state) were contained in each Markov chain...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29602408/an-update-on-hypertension-in-children-with-type-1-diabetes
#10
REVIEW
Mallory L Downie, Emma H Ulrich, Damien G Noone
The prevalence of hypertension in children with type 1 diabetes is reported to be between 6% and 16%. This potentially modifiable cardiovascular risk factor may go undiagnosed and undertreated, particularly in children with type 1 diabetes. Recent updated Canadian clinical practice guidelines recommend blood pressure screening every 2 years in children with type 1 diabetes as well as routine use of ambulatory blood pressure monitoring. Risk factors for hypertension in type 1 diabetes include poor glycemic control, overweight and obesity and genetic predisposition for hypertension...
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29596940/long-term-outcomes-associated-with-triple-goal-achievement-in-patients-with-type-2-diabetes-mellitus-t2dm
#11
Qian Shi, Shuqian Liu, Marie Krousel-Wood, Hui Shao, Vivian Fonseca, Lizheng Shi
AIMS: This study was designed to compare the risk of long-term health outcomes, including microvascular, macrovascular complications and mortality, across 4 cohorts: triple-goal, dual-goal, single-goal, and no-goal achievers. METHODS: A retrospective cohort of 53,120 patients with T2DM were identified (97.51% male, 61.49% whites) from the Veterans Affairs (VA) electronic medical records VISN 16 data warehouse (2004-2010). Propensity score weight (PSW) was used to balance demographic characteristics and complication history at baseline...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29565290/role-of-inflammation-in-diabetic-retinopathy
#12
REVIEW
Anne Rübsam, Sonia Parikh, Patrice E Fort
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of blindness among the working-age population. For decades, diabetic retinopathy was considered only a microvascular complication, but the retinal microvasculature is intimately associated with and governed by neurons and glia, which are affected even prior to clinically detectable vascular lesions. While progress has been made to improve the vascular alterations, there is still no treatment to counteract the early neuro-glial perturbations in diabetic retinopathy...
March 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29559805/moderate-glucose-supply-reduces-hemolysis-during-systemic-inflammation
#13
Johannes Jägers, Stephan Brauckmann, Michael Kirsch, Katharina Effenberger-Neidnicht
Background: Systemic inflammation alters energy metabolism. A sufficient glucose level, however, is most important for erythrocytes, since erythrocytes rely on glucose as sole source of energy. Damage to erythrocytes leads to hemolysis. Both disorders of glucose metabolism and hemolysis are associated with an increased risk of death. The objective of the study was to investigate the impact of intravenous glucose on hemolysis during systemic inflammation. Materials and methods: Systemic inflammation was accomplished in male Wistar rats by continuous lipopolysaccharide (LPS) infusion (1 mg LPS/kg and h, 300 min)...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29556093/hypertension-with-diabetes-mellitus-physiology-and-pathology
#14
REVIEW
Mitsuru Ohishi
Elevated blood pressure is closely related to increased circulatory fluid volume and peripheral vascular resistance. Patients with diabetes mellitus experience increased peripheral artery resistance caused by vascular remodeling and increased body fluid volume associated with insulin resistance-induced hyperinsulinemia and hyperglycemia. Both of these mechanisms elevate systemic blood pressure. Thus, fully understanding the pathophysiology of hypertension in diabetes mellitus requires knowing the natural history of type 2 diabetes...
March 19, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29555068/structural-basis-of-bioactivity-of-food-peptides-in-promoting-metabolic-health
#15
Shixiang Yao, Dominic Agyei, Chibuike C Udenigwe
Bioactive peptides have many structural features that enable them to become functional in controlling several biological processes in the body, especially those related to metabolic health. This chapter provides an overview of the multiple targets of food-derived peptides against metabolic health problems (e.g., hypertension, dyslipidemia, hyperglycemia, oxidative stress) and discusses the importance of structural chemistry in determining the bioactivities of peptides and protein hydrolysates.
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29547847/lipid-peroxidation-regulates-podocyte-migration-and-cytoskeletal-structure-through-redox-sensitive-rhoa-signaling
#16
Claudia Kruger, Susan J Burke, J Jason Collier, Trang-Tiffany Nguyen, J Michael Salbaum, Krisztian Stadler
Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion. The role of oxidative stress has been implicated in CKD but it is not known how exactly free radicals affect podocyte physiology. To assess this relationship, we investigated the effects of lipid radicals on podocytes, as lipid peroxidation is a major form of oxidative stress in diabetes...
March 6, 2018: Redox Biology
https://www.readbyqxmd.com/read/29535944/lipid-profile-in-relation-to-glycemic-control-in-type-1-diabetes-children-and-adolescents-in-bangladesh
#17
Bedowra Zabeen, Ana Margarida Balsa, Nasreen Islam, Mukta Parveen, Jebun Nahar, Kishwar Azad
Introduction: Dyslipidemia and hyperglycemia are metabolic abnormalities commonly found in young patients with Type 1 diabetes mellitus (T1DM) and both increase the risk of cardiovascular disease. Methods: This cross-sectional study was aimed to evaluate the pattern of dyslipidemia and its relationship with other risk factors in children and adolescents with T1DM. A total of 576 T1DM patients aged 10-18 years who attended Changing Diabetes in Children, a pediatric diabetes clinic in Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders over 1 year period from July 2015 to June 2016 were included in this study...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29531434/metabolic-syndrome-among-adults-of-surendranagar-district-of-saurashtra-gujarat-a-cross-sectional-study
#18
Chaitanya Gopalrao Chinawale, Dipak V Parmar, Parth Kavathia, Twinkle Rangnani, Jainy Thakkar, Girija Kartha
Background: The metabolic syndrome (MetS) is a complex disorder and a major health concern in developing countries. Data on MetS in Indian population show multiplicity. There are no published reports about the prevalence of MetS in population of Saurashtra region, Gujarat. The aim of this study is to assess the prevalence of MetS and its components in adult population of this region. Methods: This cross-sectional observational study was carried out among 473 participants who attended free health checkup camps...
January 2018: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29523524/genome-wide-association-study-identifies-the-hmgcs2-locus-to-be-associated-with-chlorthalidone-induced-glucose-increase-in-hypertensive-patients
#19
Sonal Singh, Caitrin W McDonough, Yan Gong, Wael A Alghamdi, Meghan J Arwood, Salma A Bargal, Leanne Dumeny, Wen-Yi Li, Mai Mehanna, Bradley Stockard, Guang Yang, Felipe A de Oliveira, Natalie C Fredette, Mohamed H Shahin, Kent R Bailey, Amber L Beitelshees, Eric Boerwinkle, Arlene B Chapman, John G Gums, Stephen T Turner, Rhonda M Cooper-DeHoff, Julie A Johnson
BACKGROUND: Thiazide and thiazide-like diuretics are first-line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide-like diuretic/chlorthalidone-induced glucose change. METHODS AND RESULTS: Genome-wide analysis of glucose change after treatment with chlorthalidone was performed by race among the white (n=175) and black (n=135) participants from the PEAR-2 (Pharmacogenomic Evaluation of Antihypertensive Responses-2)...
March 9, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29509232/peri-implant-diseases-and-metabolic-syndrome-components-a-systematic-review
#20
P Papi, C Letizia, A Pilloni, L Petramala, V Saracino, D Rosella, G Pompa
OBJECTIVE: Metabolic syndrome (MetS) is defined as a spectrum of conditions associated with an increased risk of developing CVD and type 2 diabetes. MetS include: hyperglycemia, hypertension, visceral obesity, dyslipidemia with elevated values of triglycerides (TG) and low levels of HDL. The aim of this review is to provide current knowledge of the relationship between MetS, its components and peri-implant diseases. MATERIALS AND METHODS: An electronic literature search was conducted in the English language in several databases...
February 2018: European Review for Medical and Pharmacological Sciences
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