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https://www.readbyqxmd.com/read/29897925/longitudinal-study-of-body-mass-index-dyslipidemia-hyperglycemia-and-hypertension-in-60-000-men-and-women-in-sweden-and-austria
#1
Mieke Van Hemelrijck, Hanno Ulmer, Gabriele Nagel, Raphael Simon Peter, Josef Fritz, Robin Myte, Bethany van Guelpen, Bernhard Föger, Hans Concin, Christel Häggström, Pär Stattin, Tanja Stocks
BACKGROUND: Obesity is suggested to underlie development of other metabolic aberrations, but longitudinal relationships between metabolic factors at various ages has not been studied in detail. METHODS: Data from 27,379 men and 32,275 women with in total 122,940 health examinations in the Västerbotten Intervention Project, Sweden and the Vorarlberg Health Monitoring and Prevention Programme, Austria were used to investigate body mass index (BMI), mid-blood pressure, and fasting levels of glucose, triglycerides, and total cholesterol at baseline in relation to 10-year changes of these factors and weight...
2018: PloS One
https://www.readbyqxmd.com/read/29895272/association-between-sleep-duration-and-metabolic-syndrome-a-cross-sectional-study
#2
Claire E Kim, Sangah Shin, Hwi-Won Lee, Jiyeon Lim, Jong-Koo Lee, Aesun Shin, Daehee Kang
BACKGROUND: Both short and long sleep duration have been consistently studied as a risk factor for obesity, hyperglycemia and hypertension. In this cross-sectional study, we provide an updated analysis of the Health Examinees (HEXA) study on the association between sleep duration and metabolic syndrome (MetS) occurrence among Koreans age 40-69 year olds. METHODS: A total of 133,608 subjects (44,930 men, 88,678 women) were enrolled in the HEXA study 2004-2013. Sleep duration was categorized into 4 sleep categories (< 6 h, 6 to < 8 h, 8 to < 10 h, ≥10 h)...
June 13, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29895010/metabolic-syndrome-in-thyroid-disease
#3
K Alexander Iwen, Rebecca Oelkrug, Hannes Kalscheuer, Georg Brabant
Cardiometabolic risk factors like abdominal obesity, hyperglycemia, low high-density lipoprotein (HDL) cholesterol, elevated triglycerides, and hypertension are defined as metabolic syndrome (MetS), which represents one of the most frequent endocrine disorders particularly in a society with increasing weight problems. As more and more evidence is accumulated that thyroid hormones affect components of the MetS, the present review aims to summarize the rapidly expanding knowledge on the pathophysiological interaction between thyroid hormone status and MetS...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29893026/joint-interaction-effect-of-metabolic-syndrome-and-obstructive-sleep-apnea-on-hypertension
#4
Xiaolong Zhao, Huajun Xu, Jianyin Zou, Yingjun Qian, Hongliang Yi, Jian Guan, Shankai Yin
Numerous studies have observed a relationship between obstructive sleep apnea and hypertension, but the effects of metabolic syndrome on hypertension, and their interaction with obstructive sleep apnea, remain unclear. For this study, a total of 2972 patients were recruited from the Shanghai Sleep Health Study. Data from overnight polysomnography parameters, serum lipids, fasting blood glucose, blood pressure, and anthropometric measurements were collected. The authors then explored the independent associations and multiplicative and additive interactions of predictors of metabolic syndrome with hypertension...
June 12, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29891771/role-of-magnesium-deficiency-in-promoting-atherosclerosis-endothelial-dysfunction-and-arterial-stiffening-as-risk-factors-for-hypertension
#5
REVIEW
Krasimir Kostov, Lyudmila Halacheva
Arterial hypertension is a disease with a complex pathogenesis. Despite considerable knowledge about this socially significant disease, the role of magnesium deficiency (MgD) as a risk factor is not fully understood. Magnesium is a natural calcium antagonist. It potentiates the production of local vasodilator mediators (prostacyclin and nitric oxide) and alters vascular responses to a variety of vasoactive substances (endothelin-1, angiotensin II, and catecholamines). MgD stimulates the production of aldosterone and potentiates vascular inflammatory response, while expression/activity of various antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase) and the levels of important antioxidants (vitamin C, vitamin E, and selenium) are decreased...
June 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29883377/circulating-phospholipid-patterns-in-nafld-patients-associated-with-a-combination-of-metabolic-risk-factors
#6
Shilpa Tiwari-Heckler, Hongying Gan-Schreier, Wolfgang Stremmel, Walee Chamulitrat, Anita Pathil
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is associated with inefficient macro- and micronutrient metabolism, and alteration of circulating phospholipid compositions defines the signature of NAFLD. This current study aimed to assess the pattern of serum phospholipids in the spectrum of NAFLD, and its related comorbidities and genetic modifications. METHODS: 97 patients with diagnosed NAFLD were recruited at a single center during 2013⁻2016. Based on histological and transient elastography assessment, 69 patients were divided into non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver (NAFL) subgroups...
May 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29879952/prediction-of-the-development-of-metabolic-syndrome-by-the-markov-model-based-on-a-longitudinal-study-in-dalian-city
#7
Xiao Tang, Qigui Liu
BACKGROUND: Metabolic syndrome (MetS) increases the incidence of cardiovascular disease and diabetes mellitus. It is essential to study the natural progression of MetS in the interest of prevention. Information on the dynamic changes in MetS in developing countries is limited. This study aimed to simulate the progression of each component of MetS and explore the potential role of these components in early prevention and intervention. METHODS: This study involved 5881 individuals, aged 20 to 60 at study entry, who underwent at least two consecutive years of health check-ups in the seven-year study period at our institution's health check-up center...
June 7, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29870676/fecal-transplant-from-resveratrol-fed-donors-improves-glycaemia-and-cardiovascular-features-of-the-metabolic-syndrome-in-mice
#8
Ty T Kim, Nirmal Parajuli, Miranda M Sung, Suresh C Bairwa, Jody Levasseur, Carrie-Lynn M Soltys, David S Wishart, Karen Madsen, Jonathan D Schertzer, Jason R B Dyck
Oral administration of resveratrol attenuates several symptoms associated with the metabolic syndrome such as impaired glucose homeostasis and hypertension. Recent work has shown that resveratrol can improve glucose homeostasis in obesity via changes in the gut microbiota. Studies involving fecal microbiome transplants (FMTs) suggest that either live gut microbiota or bacterial-derived metabolites from resveratrol ingestion are responsible for producing the observed benefits in recipients. Herein, we show that obese mice receiving FMTs from healthy resveratrol-fed mice have improved glucose homeostasis within 11 days of the first transplant, and that resveratrol-FMTs is more efficacious than oral supplementation of resveratrol for the same duration...
June 5, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29867137/vascular-endothelial-dysfunction-a-major-mediator-in-diabetic-cardiomyopathy
#9
REVIEW
Maura Knapp, Xin Tu, Rongxue Wu
Diabetes mellitus is currently a major public health problem. A common complication of diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients. While ischemic events are commonly observed in diabetic patients, the risk for developing heart failure is also increased, independent of the severity of coronary artery disease and hypertension. This diabetes-associated clinical entity is considered a distinct disease process referred to as "diabetic cardiomyopathy"...
June 4, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29852237/gestational-diabetes-mellitus-risk-score-a-practical-tool-to-predict-gestational-diabetes-mellitus-risk-in-tanzania
#10
REVIEW
Anna Patrick Nombo, Akwilina Wendelin Mwanri, Elske M Brouwer-Brolsma, Kaushik L Ramaiya, Edith Feskens
BACKGROUND: Universal screening for hyperglycemia during pregnancy may be in-practical in resource constrained countries. Therefore, the aim of this study was to develop a simple, non-invasive practical tool to predict undiagnosed Gestational diabetes mellitus (GDM) in Tanzania. METHODS: We used cross-sectional data of 609 pregnant women, without known diabetes, collected in six health facilities from Dar es Salaam city (urban). Women underwent screening for GDM during ante-natal clinics visit...
May 28, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29808122/stemi-in-a-young-male-after-use-of-synephrine-containing-dietary-supplement
#11
Dileep Unnikrishnan, Radhika Annam, Aasems Jacob, Braghadheeswar Thyagarajan, Peter Farrugia
A twenty-two-year-old male with no significant past medical history who presented with chest pain was found to have ST-segment elevation in leads II, III, aVF, and V4-V6. On subsequent EKGs, patient had new ST-segment elevations in anterolateral leads with dynamic changes. Cardiac catheterization showed acute dissection with thrombosis of the distal left main coronary artery leading into the ostial left anterior descending artery. The patient had no cardiac risk factors including hypertension, hyperlipidemia, diabetes, or family history of early cardiac disease...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29778650/obesity-surgery-makes-patients-healthier-and-more-functional-real-world-results-from-the-united-kingdom-national-bariatric-surgery-registry
#12
Alexander Dimitri Miras, Kamocka Anna, Patel Darshan, Dexter Simon, Finlay Ian, Hopkins C James, Khan Omar, Reddy Marcus, Sedman Peter, Small Peter, Somers Shaw, Suzie Cro, Walton Peter, le Roux Carel W, Welbourn Richard
BACKGROUND: The National Bariatric Surgery Registry (NBSR) is the largest bespoke database in the field in the United Kingdom. OBJECTIVES: Our aim was to analyze the NBSR to determine whether the effects of obesity surgery on associated co-morbidities observed in small, randomized controlled clinical trials could be replicated in a "real life" setting within U.K. healthcare. SETTING: United Kingdom. METHODS: All NBSR entries for operations between 2000 and 2015 with associated demographic and co-morbidity data were analyzed retrospectively...
February 15, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29773001/combined-administration-of-monosodium-glutamate-and-high-sucrose-diet-accelerates-the-induction-of-type-2-diabetes-vascular-dysfunction-and-memory-impairment-in-rats
#13
Kaja Saikrishna, Ringu Kumari, Kantamaneni Chaitanya, Subhankar Biswas, Pawan G Nayak, Jayesh Mudgal, Anoop Kishore, Krishnadas Nandakumar
In this study, we aimed to develop an experimental animal model for type 2 diabetes mellitus (T2DM) using a combination of monosodium glutamate (MSG) and high sucrose diet (HSD). Young male Wistar rats (20-30 g) were injected with MSG (2 or 4 mg/g, i.p. for 4 days). These rats were also fed an HSD, while the control group was fed a starch diet (SFD) for 150 days. Parameters assessed periodically were body weight, feed intake, blood glucose level, and oral glucose tolerance test (OGTT), lipid profile, liver and kidney function tests, skeletal muscle glucose uptake, cognitive function tests, and microvascular changes using isolated rat aorta...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29772620/-development-of-ectopic-adrenocorticotropic-hormone-syndrome-in-a-patient-with-prostate-cancer-during-combined-androgen-blockade-therapy
#14
Yosuke Sekii, Mitsuhiro Yoshinaga, Masahiro Nakagawa, Hidefumi Kishikawa, Kazumasa Oka, Kenji Nishimura
A 74-year old man presented to us with difficulty urinating. The laboratory examinations revealed an elevated prostate-specific antigen (PSA) level. A prostate biopsy revealed prostate adenocarcinoma. The computed tomography scan showed metastasis to lymph nodes in the pelvic cavity and both adrenal glands. Combined androgen blockade therapy was started, and PSA levels began to decrease gradually. However, 2 months later, he was hospitalized for treatment of cellulitis and was found to have hypertension, hyperglycemia, and hypokalemia...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29760304/metyrapone-responsive-ectopic-acth-secreting-pheochromocytoma-with-a-vicious-cycle-via-a-glucocorticoid-driven-positive-feedback-mechanism
#15
Minako Inoue, Ken Okamura, Chie Kitaoka, Fumio Kinoshita, Ryo Namitome, Udai Nakamura, Masaki Shiota, Kenichi Goto, Toshio Ohtsubo, Kiyoshi Matsumura, Yoshinao Oda, Masatoshi Eto, Takanari Kitazono
In ectopic ACTH-secreting pheochromocytoma, combined ACTH-driven hypercortisolemia and hyper-catecholaminemia are serious conditions, which can be fatal if not diagnosed and managed appropriately, especially when glucocorticoid-driven positive feedback is suggested with a high ACTH/cortisol ratio. A 46-year-old man presented with headache, rapid weight loss, hyperhidrosis, severe hypertension and hyperglycemia without typical Cushingoid appearance. Endocrinological examinations demonstrated elevated plasma and urine catecholamines, serum cortisol and plasma ACTH...
May 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29744365/high-salt-intake-ameliorates-hyperglycemia-and-insulin-resistance-in-wbn-kob-lepr-fa-fa-rats-a-new-model-of-type-2-diabetes-mellitus
#16
Yoshiichi Takagi, Taichi Sugimoto, Masaya Kobayashi, Mitsuyuki Shirai, Fumitoshi Asai
High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29740333/flavonoids-in-kidney-health-and-disease
#17
REVIEW
Félix Vargas, Paola Romecín, Ana I García-Guillén, Rosemary Wangesteen, Pablo Vargas-Tendero, M Dolores Paredes, Noemí M Atucha, Joaquín García-Estañ
This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and antiinflammatory effects, among other therapeutic activities. Many of them also exert renoprotective actions that may be of interest in diseases such as glomerulonephritis, diabetic nephropathy, and chemically-induced kidney insufficiency. They affect several renal factors that promote diuresis and natriuresis, which may contribute to their well-known antihypertensive effect...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29738655/-dietary-patterns-and-metabolic-syndrome-components-in-women-with-excess-weight-18-to-45-years-old
#18
Zugey Hernández-Ruiz, Sonia Rodríguez-Ramírez, Sonia Hernández-Cordero, Eric Monterrubio-Flores
OBJECTIVE: To analyze the association between dietary patterns and metabolic syndrome (MS) components in adult women with excess weight. MATERIAL AND METHODS: Cross-sectional study with anthropometric, dietary, biochemical and blood pressure data. Dietary patterns were identified by factor analysis and multiple logistic regression models were used to analyze associations. RESULTS: The prevalence of altered glucose was 14.6%, of hypertriglyceridemia 40...
March 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29731703/metabolic-syndrome-and-neuroprotection
#19
REVIEW
Melisa Etchegoyen, Mariana H Nobile, Francisco Baez, Barbara Posesorski, Julian González, Néstor Lago, José Milei, Matilde Otero-Losada
Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder. Undoubtedly, the massive and still increasing incidence of MetS places this epidemic as an important public health issue. Hereon we revisit another outlook of MetS beyond its classical association with cardiovascular disease (CVD) and Diabetes Mellitus Type 2 (DM2), for MetS also poses a risk factor for the nervous tissue and threatens neuronal function...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29730389/mothers-with-hip-the-short-term-and-long-term-impact-what-is-new
#20
REVIEW
Federico Mecacci, Serena Ottanelli, Felice Petraglia
Hyperglycemia is one of the most common medical conditions that women encounter during pregnancy and it is due to gestational diabetes (GDM) in the majority of cases [1]. GDM is associated with a higher incidence of maternal morbidity in pregnancy in term of hypertensive disorders/preclampsia and higher rate of cesarean delivery but also with long-term risk of type 2 diabetes and cardiovascular disease. Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk...
May 3, 2018: Diabetes Research and Clinical Practice
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