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https://www.readbyqxmd.com/read/29450496/association-of-metabolic-syndrome-with-sudden-sensorineural-hearing-loss
#1
Su Young Jung, Haeng Seon Shim, Young Min Hah, Sang Hoon Kim, Seung Geun Yeo
Importance: Each of the 5 diagnostic criteria or factors of metabolic syndrome-hyperglycemia or type 2 diabetes, hypertension, obesity, elevated triglyceride levels, and decreased high-density lipoprotein cholesterol level-is associated with the pathophysiologic features of sudden sensorineural hearing loss (SSNHL). Little is known, however, about the association of metabolic syndrome, defined as the presence of at least 3 of these factors, with the prognosis of SSNHL. Objective: To evaluate the association of metabolic syndrome with the rate of recovery from SSNHL...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29434010/national-prevalence-of-self-reported-coronary-heart-disease-and-chronic-stable-angina-pectoris-factor-analysis-of-the-underlying-cardiometabolic-risk-factors-in-the-fourth-round-of-the-surfncd-2011
#2
Mehrshad Abbasi, Mohamadreza Neishaboury, Jalil Koohpayehzadeh, Koorosh Etemad, Alipasha Meysamie, Fereshteh Asgari, Sina Noshad, Mohsen Afarideh, Alireza Ghajar, Morsaleh Ganji, Ali Rafei, Mostafa Mousavizadeh, Elias Khajeh, Behnam Heidari, Mohammad Saadat, Manouchehr Nakhjavani, Alireza Esteghamati
BACKGROUND: Coronary heart disease (CHD) is one of the most common causes of mortality worldwide. The national prevalence remains unclear in most of the developing countries. OBJECTIVE: This study sought to estimate national prevalence of self-reported CHD and chronic stable angina pectoris in the general adult population of Iran using data from the fourth round of the Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2011) survey. METHODS: The analysis comprised data of 11,867 civilian, nonhospitalized and noninstitutionalized residents ages 6 to 70 years of age...
February 9, 2018: Global Heart
https://www.readbyqxmd.com/read/29432575/multiple-common-co-morbidities-produce-left-ventricular-diastolic-dysfunction-associated-with-coronary-microvascular-dysfunction-oxidative-stress-and-myocardial-stiffening
#3
O Sorop, I Heinonen, M van Kranenburg, J van de Wouw, V J de Beer, T N Nguyen, Y Octavia, R W B van Duin, K Stam, R J van Geuns, P A Wielopolski, G P Krestin, A H van den Meiracker, R Verjans, M van Bilsen, A H J Danser, W J Paulus, C Cheng, W A Linke, J A Joles, M C Verhaar, J van der Velden, D Merkus, D J Duncker
Rationale: More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC) and diabetes mellitus (DM), although its pathophysiology remains incompletely understood. It has been proposed that the co-morbidities induce systemic inflammation, cardiac microvascular dysfunction and oxidative stress, leading to myocardial fibrosis, myocyte stiffening and ultimately, diastolic dysfunction...
February 8, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29421826/association-of-low-urine-ph-with-insulin-resistance-in-non-diabetic-japanese-subjects
#4
Masanori Shimodaira, Shinji Okaniwa, Tomohiro Nakayama
BACKGROUND: Epidemiology studies have revealed that patients with obesity, hyperglycemia, or hypertension are associated with a decreased urine pH. These metabolic disorders are related to insulin resistance; however, the association between urine pH and insulin resistance remains unclear. METHODS: To evaluate this association while controlling for covariates, the present study was conducted in 1084 non-diabetic Japanese subjects undergoing health examination. Fasting urine pH was analyzed using an automated urine dipstick analyzer...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29421689/diabetes-mellitus-associates-with-increased-right-ventricular-afterload-and-remodeling-in-pulmonary-arterial-hypertension
#5
Morgan E Whitaker, Vineet Nair, Shripad Sinari, Parinita Dherange, Balaji Natarajan, Lindsey Trutter, Evan L Brittain, Anna R Hemnes, Eric Austin, Kumar Patel, Stephen M Black, Joe G N Garcia, Jason X Yuan, Rebecca Vanderpool, Franz Rischard, Ayako Makino, Edward J Bedrick, Ankit A Desai
BACKGROUND: Diabetes mellitus is associated with left ventricular hypertrophy and dysfunction. Parallel studies have also reported associations between diabetes mellitus and right ventricle dysfunction and reduced survival in patients with pulmonary arterial hypertension. However, the impact of diabetes mellitus on the pulmonary vasculature has not been well-characterized. We hypothesized that diabetes mellitus and hyperglycemia could specifically influence right ventricular afterload and remodeling in patients with Group I pulmonary arterial hypertension, providing a link to their known susceptibility to right ventricular dysfunction...
February 5, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29420089/characterization-of-vascular-dysregulation-in-meriones-shawi-after-high-calorie-diet-feeding
#6
Badiaa Lyoussi, Khadija Cherkaoui-Tangi, Nicole Morel, Maurice Wibo
The present study was initiated to characterize vascular dysregulations (contraction and relaxation) associated with metabolic defects in Merions shawi, a rodent from the gerbillidae family, submitted to 12 weeks high-calorie diet. This diet induces a type 2 diabetes/metabolic syndrome phenotype with hypertension. In diabetic meriones, body weight increase was associated with hyperglycemia, increased insulinemia, and insulin resistance. Compared to lean meriones, diabetic meriones showed decreased aorta contraction to noradrenaline, which was normalized after NOS inhibition...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29410175/everolimus-as-cancer-therapy-cardiotoxic-or-an-unexpected-antiatherogenic-agent-a-narrative-review
#7
REVIEW
Georgios Karvelas, Aikaterini Roumpi, Christoforos Komporozos, Konstantinos Syrigos
Everolimus (EVE) is now approved by many agencies for the treatment of variable neoplasms. The risk of adverse events with these agent is not adequately defined. The purpose of this review was to summarize the everolimus - induced cardiotoxic effects to patients that received the specific drug as an antineoplastic factor and evaluate any possible anti-atherogenic effects due to systemic use of the drug. PubMed was searched for articles until August 2017. Articles included an expanded-access clinical trial, as well as phase 2 or 3 clinical trials (most of them were randomized)...
February 2, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29399870/assessment-of-myocardial-strain-in-children-with-risk-factors-for-atherosclerosis-with-use-of-3d-speckle-tracking-echocardiography
#8
Peixu Zhang, Dongqing Li, Yanzhuo Su, Xiaona Wang, Jianping Sun, Yang Xu, Jinghui Sun
BACKGROUND: The known risk factors for atherosclerosis such as dyslipidemia, hypertension, obesity, and fasting hyperglycemia are associated with subclinical myocardial dysfunction. We assessed myocardial strain in children who had risk factors for atherosclerosis with use of 3D speckle tracking echocardiography (3DSTE). METHODS: A total of 340 eligible children (mean age [±SD]: 9.5 [±1.9] years; range, 7.1-12.2; 189 males, 151 females). Levels of serum cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI) were investigated...
February 4, 2018: Echocardiography
https://www.readbyqxmd.com/read/29399299/self-management-levels-of-diet-and-metabolic-risk-factors-according-to-disease-duration-in-patients-with-type-2-diabetes
#9
Sukyung Cho, Minkyeong Kim, Kyong Park
BACKGROUND/OBJECTIVES: Metabolic risk factors should be managed effectively in patients with type 2 diabetes mellitus (T2DM) to prevent or delay diabetic complications. This study aimed to compare the self-management levels of diet and metabolic risk factors in patients with T2DM, according to the duration of illness, and to examine the trends in self-management levels during the recent decades. SUBJECTS/METHODS: Data were collected from the Korea National Health and Nutrition Examination Surveys (KNHANES, 1998-2014)...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29392084/cardiovascular-risk-factors-are-correlated-with-low-cognitive-function-among-older-adults-across-europe-based-on-the-share-database
#10
Joana Lourenco, Antonio Serrano, Alice Santos-Silva, Marcos Gomes, Claudia Afonso, Paula Freitas, Constanca Paul, Elisio Costa
Increased life expectancy is associated with a high prevalence of chronic, non-communicable diseases including cognitive decline and dementia. The purpose of this study was to evaluate the prevalence of cognitive impairment using three cognitive abilities (verbal fluency, numeracy and perceived memory) and their association with cardiovascular risk factors in seniors across Europe. Data from participants in wave 4 of the SHARE (Survey of Health, Ageing, and Retirement in Europe) database was used. Cognitive performance in perceived memory, verbal fluency and numeracy was evaluated using simple tests and a memory complaints questionnaire...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29390044/serum-metabolomic-profiling-of-all-cause-mortality-a-prospective-analysis-in-the-alpha-tocopherol-beta-carotene-cancer-prevention-atbc-study-cohort
#11
Jiaqi Huang, Stephanie J Weinstein, Steven C Moore, Andriy Derkach, Xing Hua, Linda M Liao, Fangyi Gu, Alison M Mondul, Joshua N Sampson, Demetrius Albanes
Tobacco use, hypertension, hyperglycemia, overweight, and inactivity are leading causes of overall and cardiovascular disease (CVD) mortality worldwide, yet the relevant metabolic alterations responsible are largely unknown. We conducted a serum metabolomic analysis of 620 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-2013). During 28 years of follow-up, there were 435 deaths (197 CVD and 107 cancer). The analysis included 406 known metabolites measured with ultra-high performance liquid chromatography/mass spectrometry-gas chromatography/mass spectrometry...
January 30, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29383020/data-mining-for-the-identification-of-metabolic-syndrome-status
#12
REVIEW
Apilak Worachartcheewan, Nalini Schaduangrat, Virapong Prachayasittikul, Chanin Nantasenamat
Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-density lipoprotein cholesterol). It is also associated with the development of diabetes mellitus (DM) type 2 and cardiovascular disease (CVD). Therefore, the rapid identification of MS is required to prevent the occurrence of such diseases...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29376248/-research-progress-of-chinese-herbs-inhibiting-nadph-oxidase
#13
Qing Zhang, Li-Shan Zhou, Hui Dong
Oxidative damage mediated by the abnormal activation of NADPH oxidase and the resulting excessive ROS generation is the pathogenesis for various diseases. Chinese herbs can play a role in the antioxidant treatment by inhibiting NADPH oxidase, which is meaningful for the treatment of pathological conditions such as injury of tissues, blood vessels and nerves, atherosclerosis, ischemia reperfusion, hypertension and hyperglycemia. In this paper, different forms of Chinese herbs including monomers, compounds and Chinese patent medicines with the inhibitory effect against NADPH oxidase would be reviewed, in order to explain and generalize their possible functions and the target mechanism for inhibition...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29368139/hypertensive-disorders-during-pregnancy-and-3%C3%A2-years-after-delivery-in-women-with-gestational-hyperglycemia
#14
C Festa, L Mattei, O Bitterman, B Pintaudi, M Framarino Dei Malatesta, P Bianchi, M Trappolini, A Colatrella, A Napoli
AIMS: Women with gestational hyperglycemia commonly experience hypertensive disorders during pregnancy. More information is needed about how hypertension develops in these patients over time. We investigated the prevalence of hypertension during and 3 years after pregnancy in Caucasian women with gestational hyperglycemia. We also investigated metabolic syndrome presence, glucose tolerance status, insulin sensitivity and insulin secretion levels in the follow-up period. METHODS: In a prospective longitudinal study with a 3-year follow-up, we assessed hypertension status and clinical-related characteristics of 103 consecutive women with gestational hyperglycemia sub-grouped according to their hypertensive status during and after pregnancy...
January 24, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29353881/hypertension-with-diabetes-mellitus-complications
#15
REVIEW
Daisuke Yamazaki, Hirofumi Hitomi, Akira Nishiyama
Chronic diabetic complications are classified as microvascular or macrovascular and contribute to mortality and loss of quality of life. Hyperglycemia plays a critical role in the pathogenesis of microvascular complications, such as diabetic retinopathy, incipient nephropathy, and neuropathy, while atherosclerosis contributes to the pathogenesis of macrovascular complications. Diabetes mellitus and hypertension are frequently present together. Among many microvascular diabetic complications, hypertension plays a predominant role in the progression of diabetic nephropathy by glomerular hyperfiltration...
January 22, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29348994/the-association-of-mediterranean-diet-and-exercise-modifications-with-anthropometric-parameters-in-a-psychiatric-community-population-a-pilot-study
#16
Rosaria Di Lorenzo, Jessica Pedretti, Letizia Grossi, Benedetta Cuoghi, Cinzia Varni, Giulia Landi, Ludovica Spattini, Chiara Visentini, Paola Ferri, Francesca Carubbi
Weight gain and related metabolic syndrome (MS) are major current issues in public health. MS consists of abdominal fat, atherogenic dyslipidemia, hypertension, hyperglycemia, insulin resistance, pro-inflammatory and pro-thrombotic state, and accounts for both cardiovascular diseases and type II diabetes mellitus risk factors. Patients affected by psychiatric illness present a prevalence of 35-40% of MS. Many studies have shown that Mediterranean diet is associated with the reduction of mortality due to cardiovascular and malignant diseases, potentially preventing both obesity and type II diabetes mellitus...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29347857/mulberry-leaves-and-their-potential-effects-against-cardiometabolic-risks-a-review-of-chemical-compositions-biological-properties-and-clinical-efficacy
#17
Thanchanit Thaipitakwong, Surawej Numhom, Pornanong Aramwit
CONTEXT: Cardiometabolic risks are regarded as the crucial factors associated with type 2 diabetes (T2DM) and cardiovascular diseases (CVD). Regarding an increased attention to medicinal plants in the current healthcare system, the effects of mulberry (Morus spp., Moraceae) leaves on cardiometabolic risks have been consecutively considered in scientific research. OBJECTIVE: The present review compiles and summarizes the chemical compositions, biological properties and clinical efficacy of mulberry leaves that are related to the amelioration of cardiometabolic risks...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29344415/rhizoma-coptidis-and-berberine-as-a-natural-drug-to-combat-aging-and-aging-related-diseases-via-anti-oxidation-and-ampk-activation
#18
REVIEW
Zhifang Xu, Wei Feng, Qian Shen, Nannan Yu, Kun Yu, Shenjun Wang, Zhigang Chen, Seiji Shioda, Yi Guo
Aging is the greatest risk factor for human diseases, as it results in cellular growth arrest, impaired tissue function and metabolism, ultimately impacting life span. Two different mechanisms are thought to be primary causes of aging. One is cumulative DNA damage induced by a perpetuating cycle of oxidative stress; the other is nutrient-sensing adenosine monophosphate-activated protein kinase (AMPK) and rapamycin (mTOR)/ ribosomal protein S6 (rpS6) pathways. As the main bioactive component of natural Chinese medicine rhizoma coptidis (RC), berberine has recently been reported to expand life span in Drosophila melanogaster, and attenuate premature cellular senescence...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29334985/role-of-sleep-duration-and-sleep-related-problems-in-the-metabolic-syndrome-among-children-and-adolescents
#19
Leonardo Pulido-Arjona, Jorge Enrique Correa-Bautista, Cesar Agostinis-Sobrinho, Jorge Mota, Rute Santos, María Correa-Rodríguez, Antonio Garcia-Hermoso, Robinson Ramírez-Vélez
BACKGROUND: There is increasing recognition that sleep is a risk factor for metabolic syndrome (MetS). The aim of the present study was to analyze the relationship between self-reported sleep duration, sleep-related problems and the presence of MetS in children and adolescents from Bogotá, D.C., Colombia. METHODS: This is a cross-sectional analysis from the FUPRECOL study (2014-15). Participants included 2779 (54.2% girls) youth from Bogota (Colombia). MetS was defined as the presence of ≥3 of the metabolic abnormalities (hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol [HDL-c], hypertension, and increased waist circumference) according to the criteria of de Ferranti/Magge and colleges...
January 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29321950/manifestations-of-renal-impairment-in-fructose-induced-metabolic-syndrome
#20
Kameliya Bratoeva, George S Stoyanov, Albena Merdzhanova, Mariya Radanova
Introduction International studies show an increased incidence of chronic kidney disease (CKD) in patients with metabolic syndrome (MS). It is assumed that the major components of MS - obesity, insulin resistance, dyslipidemia, and hypertension - are linked to renal damage through the systemic release of several pro-inflammatory mediators, such as uric acid (UA), C-reactive protein (CRP), and generalized oxidative stress. The aim of the present study was to investigate the extent of kidney impairment and manifestations of dysfunction in rats with fructose-induced MS...
November 7, 2017: Curēus
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