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https://www.readbyqxmd.com/read/27749762/infectious-complications-and-immune-inflammatory-response-in-cardiogenic-shock-patients-a-prospective-observational-study
#1
Jiri Parenica, Jiri Jarkovsky, Jan Malaska, Alexandre Mebazaa, Jana Gottwaldova, Katerina Helanova, Jiri Litzman, Milan Dastych, Josef Tomandl, Jindrich Spinar, Ludmila Dostalova, Petr Lokaj, Marie Tomandlova, Monika Goldergova Pavkova, Pavel Sevcik, Matthieu Legrand
INTRODUCTION: Cardiogenic shock (CS) patients are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring non-infectious inflammatory response, which accompanies an extensive myocardial infarction or a post-cardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers...
September 29, 2016: Shock
https://www.readbyqxmd.com/read/27544604/prognostic-value-of-myeloperoxidase-concentration-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#2
Michal Kacprzak, Marzenna Zielinska
: Inflammation plays an important role on every stage of atherosclerosis. Myeloperoxidase (MPO), a leukocyte-derived enzyme that participates in the innate immunity, probably is involved in many stages of atherothrombosis. According to the recent studies, MPO is related with unfavorable outcome in patients with chest pain and acute coronary syndromes. Its role in prediction of outcomes after ST-segment elevation myocardial infarction (STEMI) remains unclear. The aim of the study was to assess if elevated MPO level is a predictor of long-term adverse cardiac events in patients with STEMI treated with primary percutaneous coronary intervention (pPCI)...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27236113/expression-of-functional-tissue-factor-in-activated-t-lymphocytes-in-vitro-and-in-vivo-a-possible-contribution-of-immunity-to-thrombosis
#3
Raffaele De Palma, Plinio Cirillo, Giovanni Ciccarelli, Giusi Barra, Stefano Conte, Grazia Pellegrino, Giuseppe Pasquale, Giovanni Nassa, Francesco Pacifico, Antonio Leonardi, Luigi Insabato, Gaetano Calì, Paolo Golino, Giovanni Cimmino
OBJECTIVE: T-lymphocyte activation plays an important role in the pathophysiology of acute coronary syndromes (ACS). Plaques from ACS patients show a selective oligoclonal expansion of T-cells, indicating a specific, antigen-driven recruitment of T-lymphocytes within the unstable lesions. At present, however, it is not known whether T-cells may contribute directly to thrombosis by expressing functional tissue factor (TF). Accordingly, the aim of the present study was to investigate whether T-cells are able to express functional TF in their activated status...
September 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27188383/two-parameters-reflect-lipid-driven-inflammatory-state-in-acute-coronary-syndrome-atherogenic-index-of-plasma-neutrophil-lymphocyte-ratio
#4
Youqin Zhan, Tan Xu, Xuerui Tan
BACKGROUND: Atherosclerosis is a systemic, lipid-driven immune-inflammatory disease. METHODS: We retrospectively reviewed institutional electronic medical records to seek chest pain patients who were suspicious of acute coronary syndrome (ACS) between January 2011 and December 2013. All the patients were identified by undergoing coronary angiography. On admission white blood cell and its subtypes were measured as part of the automated complete blood count and fasting venous blood samples were obtained and analyzed for lipids profiles used automated analysis...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/26798071/cytotoxin-associated-gene-antigen-positive-strains-of-helicobacter-pylori-and-recurring-acute-coronary-syndromes
#5
Giampaolo Niccoli, Marco Roberto, Domenico D'Amario, Giancarla Scalone, Francesco Fracassi, Nicola Cosentino, Marcello Candelli, Francesco Franceschi, Filippo Crea
BACKGROUND: Cytotoxin-associated gene antigen (CagA)-positive strains of Helicobacter pylori have previously been associated with acute coronary syndromes. However, the role of CagA-positive strains of Helicobacter pylori in recurring cardiac events after ST-segment elevation myocardial infarction (STEMI) has not yet been assessed. METHODS: We enrolled 181 consecutive patients (155 men, mean age 64±13 years) presenting with STEMI. In all patients, serum levels of IgG anti-CagA were assessed...
January 21, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/26509087/reversible-myocarditis-and-pericarditis-after-black-widow-spider-bite-or-kounis-syndrome
#6
Mehmet Yaman, Turkan Mete, Ismail Ozer, Elif Yaman, Osman Beton
Clinical manifestation of black widow spider bite is variable and occasionally leads to death in rural areas. Cases of myocarditis and pericarditis after black widow spider bite are rare and the associated prognostic significance is unknown. Kounis syndrome has been defined as an acute coronary syndrome in the setting of allergic or hypersensitivity and anaphylactic or anaphylactoid insults that manifests as vasospastic angina or acute myocardial infarction or stent thrombosis. Allergic myocarditis is caused by myocardial inflammation triggered by infectious pathogens, toxic, ischemic, or mechanical injuries, such as drug-related inflammation and other immune reactions...
2015: Case Reports in Cardiology
https://www.readbyqxmd.com/read/25129664/mechanisms-of-atherothrombosis-and-vascular-response-to-primary-percutaneous-coronary-intervention-in-women-versus-men-with-acute-myocardial-infarction-results-of-the-octavia-study
#7
MULTICENTER STUDY
Giulio Guagliumi, Davide Capodanno, Francesco Saia, Giuseppe Musumeci, Giuseppe Tarantini, Roberto Garbo, Gabriele Tumminello, Vasile Sirbu, Micol Coccato, Massimo Fineschi, Carlo Trani, Mauro De Benedictis, Ugo Limbruno, Leonardo De Luca, Giampaolo Niccoli, Hiram Bezerra, Elena Ladich, Marco Costa, Giuseppe Biondi Zoccai, Renu Virmani
OBJECTIVES: This study sought to assess in vivo sex differences in the pathophysiology of ST-segment elevation myocardial infarction (STEMI) and vascular response to primary percutaneous coronary intervention (PCI). BACKGROUND: There is no consensus on whether differences in the pathophysiology of STEMI and response to primary PCI between women and men reflect biological factors as opposed to differences in age. METHODS: In this prospective, multicenter study, 140 age-matched men and women with STEMI undergoing primary PCI with everolimus-eluting stent were investigated with intravascular optical coherence tomography, histopathology-immunohistochemistry of thrombus aspirates, and serum biomarkers...
September 2014: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/24459590/two-cases-and-review-of-the-literature-primary-percutaneous-angiography-and-antiplatelet-management-in-patients-with-immune-thrombocytopenic-purpura
#8
REVIEW
Estelle Torbey, Harout Yacoub, Donald McCord, James Lafferty
We report two cases of immune thrombocytopenic purpura (ITP) associated with acute coronary artery syndrome highlighting the interventions done in every case along with the medications used during intervention and as outpatient. The first case is that of a woman with ITP exacerbation while on dual antiplatelet therapy and the second case is that of a male presenting with non-ST elevation myocardial infarction (NSTEMI) while in a thrombocytopenic crisis. In both cases antiplatelet therapy was held and thrombopoietic therapy was initiated before resuming full anticoagulation and coronary intervention...
December 29, 2013: ISRN Hematology
https://www.readbyqxmd.com/read/24389343/systemic-toll-like-receptor-and-interleukin-18-pathway-activation-in-patients-with-acute-st-elevation-myocardial-infarction
#9
Tineke C T M van der Pouw Kraan, Flip J P Bernink, Cansu Yildirim, Pieter Koolwijk, Josefien M Baggen, Leo Timmers, Aernout M Beek, Michaela Diamant, Weena J Y Chen, Albert C van Rossum, Niels van Royen, Anton J G Horrevoets, Yolande E Appelman
Acute myocardial infarction (AMI) is accompanied by increased expression of Toll like receptors (TLR)-2 and TLR4 on circulating monocytes. In animal models, blocking TLR2/4 signaling reduces inflammatory cell influx and infarct size. The clinical consequences of TLR activation during AMI in humans are unknown, including its role in long-term cardiac functional outcome Therefore, we analyzed gene expression in whole blood samples from 28 patients with an acute ST elevation myocardial infarction (STEMI), enrolled in the EXenatide trial for AMI patients (EXAMI), both at admission and after 4-month follow-up, by whole genome expression profiling and real-time PCR...
February 2014: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/24361942/t-lymphocytes-alterations-are-associated-with-oxidized-ldl-troponin-t-white-blood-cells-and-c-reactive-protein-during-acute-myocardial-infarction
#10
Patrícia Napoleão, Mafalda Selas, Cláudia Freixo, Miguel Mota Carmo, Ana Maria Viegas-Crespo, Rui Cruz Ferreira, Teresa Pinheiro
BACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocytes, ox-LDL, markers of myocardial necrosis (cTnT), myocardial dysfunction (N-terminal pro-brain natriuretic peptide - NT-proBNP) and inflammation (C-reactive protein - CRP) in the setting of acute myocardial infarction...
2013: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/24361877/polymorphism-of-stromal-cell-derived-factor-1-selectively-upregulates-gene-expression-and-is-associated-with-increased-susceptibility-to-coronary-artery-disease
#11
Xiao-Long Gu, Na Ma, Ding-Cheng Xiang, Jun Huang, Zheng-Hua Dong, Hui-Yan Lei, Ru Ding, Zhi-Hua Gong, Yan-Fei Wen, Jian Qiu, Lan Ma
Stromal cell-derived factor-1 (SDF-1) plays critical roles in vascular development and hematopoiesis. Here, we investigated the function of SDF-1 rs1801157G/A polymorphism in various immune cells and examined its association with susceptibility to coronary artery disease (CAD). Protein and mRNA levels of SDF-1 were tested in peripheral CD4+ T cell, CD8+ T cells, monocytes, and natural killer (NK) T cells from healthy donors with different genotypes of rs1801157G/A polymorphism. Prevalence of the polymorphism was compared between CAD patients and healthy controls...
January 17, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24298947/natural-killer-nk-cell-deficit-in-coronary-artery-disease-no-aberrations-in-phenotype-but-sustained-reduction-of-nk-cells-is-associated-with-low-grade-inflammation
#12
RANDOMIZED CONTROLLED TRIAL
K Backteman, J Ernerudh, L Jonasson
Although reduced natural killer (NK) cell levels have been reported consistently in patients with coronary artery disease (CAD), the clinical significance and persistence of this immune perturbation is not clarified. In this study we characterized the NK cell deficit further by determining (i) differentiation surface markers and cytokine profile of NK cell subsets and (ii) ability to reconstitute NK cell levels over time. Flow cytometry was used to analyse NK cell subsets and the intracellular cytokine profile in 31 patients with non-ST elevation myocardial infarction (non-STEMI), 34 patients with stable angina (SA) and 37 healthy controls...
January 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24090746/local-immune-activity-in-acute-coronary-syndrome-oxldl-abrogates-lps-tolerance-in-mononuclear-cells-isolated-from-culprit-lesion
#13
Ivan Monteleone, Saverio Muscoli, Noemi Terribili, Francesca Zorzi, Enrica Mariano, Jawahar L Mehta, Francesco Pallone, Giovanni Monteleone, Francesco Romeo
BACKGROUND: OxLDL plays a major role in the initiation and progression of atherosclerotic lesions even though further factors are needed to promote fibrous cap rupture and thrombotic occlusion of the arterial lumen. Pathogens have been implicated in this process but it remains unclear how they can cooperate with oxLDL in amplifying the destructive inflammatory response. OBJECTIVE: To phenotypically analyze culprit coronary inflammatory cells, evaluate their responsiveness to endotoxins and ascertain whether oxLDL alters the sensitivity of coronary mononuclear cells to bacterial components...
October 25, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23271203/t-lymphocytes-alterations-are-associated-with-oxidized-ldl-troponin-t-white-blood-cells-and-c-reactive-protein-during-acute-myocardial-infarction
#14
Patrícia Napoleão, Mafalda Selas, Cláudia Freixo, Miguel Mota Carmo, Ana Maria Viegas-Crespo, Rui Cruz Ferreira, Teresa Pinheiro
No abstract text is available yet for this article.
2014: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/22964478/osteoprotegerin-predicts-long-term-outcome-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#15
Sune Pedersen, Rasmus Mogelvang, Mette Bjerre, Jan Frystyk, Allan Flyvbjerg, Soren Galatius, Tor Biering Sørensen, Allan Iversen, Anders Hvelplund, Jan S Jensen
BACKGROUND: Osteoprotegerin (OPG) is a glycoprotein with a regulatory role in immune, skeletal and vascular systems. Data suggest that high circulating OPG levels are associated with an increased risk of cardiovascular disease. We analyzed the association between OPG and long-term outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). METHODS: We included 716 consecutive STEMI patients admitted to a single high-volume invasive heart center from September 2006 to December 2008...
2012: Cardiology
https://www.readbyqxmd.com/read/22956509/circulating-levels-of-interleukin-17-and-cardiovascular-outcomes-in-patients-with-acute-myocardial-infarction
#16
RANDOMIZED CONTROLLED TRIAL
Tabassome Simon, Soraya Taleb, Nicolas Danchin, Ludivine Laurans, Benoit Rousseau, Simon Cattan, Jean-Michel Montely, Olivier Dubourg, Alain Tedgui, Salma Kotti, Ziad Mallat
AIM: Interleukin (IL)-17 pathway is being clinically targeted in immune-mediated diseases, most of which are associated with a significant cardiovascular risk. We investigated the relationship between serum levels of IL-17 and the risk of cardiovascular events in patients with acute myocardial infarction. METHODS AND RESULTS: We used data from 981 patients enrolled in the prospective, multicentre French registry of Acute ST elevation, or non-ST-elevation Myocardial Infarction (Fast-MI, NCT00673036)...
February 2013: European Heart Journal
https://www.readbyqxmd.com/read/22931953/identification-and-predictive-value-of-interleukin-6-interleukin-10-and-interleukin-6-interleukin-10-cytokine-patterns-in-st-elevation-acute-myocardial-infarction
#17
Enrico Ammirati, Carlo V Cannistraci, Nicole A Cristell, Viviana Vecchio, Alessio G Palini, Per Tornvall, Anna M Paganoni, Ewa A Miendlarzewska, Laura M Sangalli, Alberto Monello, John Pernow, Marie Björnstedt Bennermo, Giancarlo Marenzi, Dayi Hu, Neal G Uren, Domenico Cianflone, Timothy Ravasi, Angelo A Manfredi, Attilio Maseri
RATIONALE: At the onset of ST-elevation acute myocardial infarction (STEMI), patients can present with very high circulating interleukin-6 (IL-6(+)) levels or very low-IL-6(-) levels. OBJECTIVE: We compared these 2 groups of patients to understand whether it is possible to define specific STEMI phenotypes associated with outcome based on the cytokine response. METHODS AND RESULTS: We compared 109 patients with STEMI in the top IL-6 level (median, 15...
October 26, 2012: Circulation Research
https://www.readbyqxmd.com/read/22494099/recruitment-of-circulating-dendritic-cell-precursors-into-the-infarcted-myocardium-and-pro-inflammatory-response-in-acute-myocardial-infarction
#18
Daniel Kretzschmar, Stefan Betge, Alexander Windisch, Rudin Pistulli, Ilonka Rohm, Michael Fritzenwanger, Christian Jung, Katja Schubert, Bernhard Theis, Iver Petersen, Stefanie Drobnik, Gita Mall, Hans-Reiner Figulla, Atilla Yilmaz
DC (dendritic cells) play an important role in the immune system. They invade peripheral tissues to detect harmful antigens, inducing a local immune response. Studies suggest that DCPs (dendritic cell precursors) might be reduced in AMI (acute myocardial infarction); however, the reason for their reduction is unknown yet. In the present study, circulating mDCPs (myeloid DCPs), pDCPs (plasmacytoid DCPs), tDCPs (total DCPs) and serum levels of TNFα (tumour necrosis factor α), IL (interleukin)-2, -4, -5, -6, -10 and -12 were analysed by flow cytometry in blood of patients with NSTEMI [non-STEMI (ST-segment elevation myocardial infarction)] (n=44) and STEMI (n=34) compared with controls with excluded CAD (coronary artery disease) (n=45)...
September 2012: Clinical Science (1979-)
https://www.readbyqxmd.com/read/22423609/innate-immunity-markers-in-culprit-plaques-of-acute-myocardial-infarction-or-stable-angina
#19
Cheol Whan Lee, Ilseon Hwang, Chan-Sik Park, Hyangsin Lee, Duk-Woo Park, Su-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Seung-Jung Park
We analyzed the innate immunity markers, C-reactive protein (CRP), serum amyloid P component (SAP) and pentraxin-3 (PTX-3), and metalloproteinase-9 (MMP-9) in coronary atherectomy tissues obtained from patients with acute ST elevation myocardial infarction (STEMI) (n=27) or stable angina (n=15). The relative areas immunopositive for CRP and SAP were similar in the two groups. In contrast, the proportion of areas immunopositive for PTX-3 and MMP-9 was higher in the STEMI group, compared to the stable angina group...
May 2012: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/22204377/anti-inflammatory-treatment-of-acute-coronary-syndromes
#20
REVIEW
R Della Bona, G Liuzzo, D Pedicino, F Crea
The past decade has seen a steady growth in the treatment options available for Acute Coronary Syndromes (ACS), as a consequence of our better understanding of ACS pathophysiology. Administration of fibrinolytics in ST-elevation myocardial infarction, and of potent antiplatelet and anticoagulant drugs in all ACS, has allowed us to considerably improve their outcome. Yet, the rate of adverse cardiac events at early follow-up ranges from 15% to 20%. Thus, to further improve the outcome of ACS or to prevent their occurrence, it is important to identify new therapeutic target...
December 2011: Current Pharmaceutical Design
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