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Drug induced Memory loss

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https://www.readbyqxmd.com/read/29873251/the-melatonin-analog-iqm316-may-induce-adult-hippocampal-neurogenesis-and-preserve-recognition-memories-in-mice
#1
Joana Figueiro-Silva, Desireé Antequera, Consuelo Pascual, Mario de la Fuente Revenga, Huayqui Volt, Darío Acuña-Castroviejo, María Isabel Rodríguez-Franco, Eva Carro
Neurogenesis in the adult hippocampus is a unique process in neurobiology that requires functional integration of newly generated neurons, which may disrupt existing hippocampal network connections and consequently loss of established memories. As neurodegenerative diseases characterized by abnormal neurogenesis and memory dysfunctions are increasing, the identification of new anti-aging drugs is required. In adult mice, we found that melatonin, a well-established neurogenic hormone, and the melatonin analog 2-(2-(5-methoxy-1 H-indol-3-yl)ethyl)-5-methyl-1,3,4-oxadiazole (IQM316) were able to induce hippocampal neurogenesis, measured by neuronal nuclei (NeuN) and 5-bromo-2'-deoxyuridine (BrdU) labeling...
March 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29864948/d-galactose-and-aluminium-chloride-induced-rat-model-with-cognitive-impairments
#2
Samaila Musa Chiroma, Mohamad Aris Mohd Moklas, Che Norma Mat Taib, Mohamad Taufik Hidayat Baharuldin, Zulkhairi Amon
Cognitive impairments and cholinergic dysfunctions have been well reported in old age disorders including Alzheimer's disease (AD). d-galactose (D-gal) has been reported as a senescence agent while aluminium act as a neurotoxic metal, but little is known about their combined effects at different doses. The aim of this study was to establish an animal model with cognitive impairments by comparing the effects of different doses of co-administrated D-gal and aluminium chloride (AlCl3 ). In this study male albino wistar rats were administered with D-gal 60 mg/kg...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29667130/beneficial-effects-of-the-calcium-channel-blocker-ctk-01512-2-in-a-mouse-model-of-multiple-sclerosis
#3
Rodrigo B M Silva, Samuel Greggio, Gianina T Venturin, Jaderson C da Costa, Marcus V Gomez, Maria M Campos
Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of this molecule in the mouse model of experimental autoimmune encephalomyelitis (EAE). The effects of CTK 01512-2 were compared to those displayed by ziconotide-a selective N-type VGCC blocker clinically used for chronic pain-and fingolimod-a drug employed for MS treatment...
April 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29659380/effect-of-pioglitazone-and-simvastatin-in-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairment-in-mice-possible-role-of-glutamatergic-pathway-and-oxidative-stress
#4
Sara Thabit, Nesrine S E El Sayed
Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and neuroprotective effects that could delay neurodegeneration and neuronal loss in diabetic and hypercholesterolemic patients. The aim of the present study was to investigate the protective effect of simvastatin, pioglitazone, and their combination in lipopolysaccharide (LPS)-induced neuroinflammation and amyloidogenesis...
April 13, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29492862/differential-prescribing-of-antimuscarinic-agents-in-older-adults-with-cognitive-impairment
#5
Scott Martin Vouri, Mario Schootman, Seth A Strope, Stanley J Birge, Margaret A Olsen
BACKGROUND: Oral oxybutynin has been associated with the development of cognitive impairment. OBJECTIVE: The objective of this study was to describe the use of oral oxybutynin versus other antimuscarinics (e.g., tolterodine, darifenacin, solifenacin, trospium, fesoterodine, transdermal oxybutynin) in older adults with documented cognitive impairment. METHODS: This is a population-based retrospective analysis of antimuscarinic new users aged ≥ 66 years from January 2008 to December 2011 (n = 42,886) using a 5% random sample of Medicare claims linked with Part D data...
April 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29439327/stabilized-low-n-amyloid-%C3%AE-oligomers-induce-robust-novel-object-recognition-deficits-associated-with-inflammatory-synaptic-and-gabaergic-dysfunction-in-the-rat
#6
William Watremez, Joshua Jackson, Bushra Almari, Samantha L McLean, Ben Grayson, Joanna C Neill, Nicolas Fischer, Ahmad Allouche, Violette Koziel, Thierry Pillot, Michael K Harte
BACKGROUND: With current treatments for Alzheimer's disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD. A new hypothesis has emerged, in which early memory loss is considered a synapse failure caused by soluble amyloid-β oligomers (Aβo). These small soluble Aβo, which precede the formation of larger fibrillar assemblies, may be the main cause of early AD pathologies...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29435980/the-diabetes-drug-liraglutide-reverses-cognitive-impairment-in-mice-and-attenuates-insulin-receptor-and-synaptic-pathology-in-a-non-human-primate-model-of-alzheimer-s-disease
#7
Andre F Batista, Leticia Forny-Germano, Julia R Clarke, Natalia M Lyra E Silva, Jordano Brito-Moreira, Susan E Boehnke, Andrew Winterborn, Brian C Coe, Ann Lablans, Juliana F Vital, Suelen A Marques, Ana Mb Martinez, Matthias Gralle, Christian Holscher, William L Klein, Jean-Christophe Houzel, Sergio T Ferreira, Douglas P Munoz, Fernanda G De Felice
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease-modifying therapeutics. Given the increasingly recognized link between AD and defective brain insulin signaling, we investigated the actions of liraglutide, a glucagon-like peptide-1 (GLP-1) analog marketed for treatment of type 2 diabetes, in experimental models of AD. Insulin receptor pathology is an important feature of AD brains that impairs the neuroprotective actions of central insulin signaling...
May 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29404958/peripheral-and-central-effects-of-memantine-in-a-mixed-preclinical-mice-model-of-obesity-and-familial-alzheimer-s-disease
#8
Miren Ettcheto, Elena Sánchez-López, Yaiza Gómez-Mínguez, Henrry Cabrera, Oriol Busquets, Carlos Beas-Zarate, Maria Luisa García, Eva Carro, Gemma Casadesus, Carme Auladell, Manuel Vázquez Carrera, Jaume Folch, Antoni Camins
There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging are risk factors for the development of Alzheimer's disease (AD). However, the molecular mechanisms through which obesity interacts with β-amyloid (Aβ) to promote cognitive decline remains poorly understood. Memantine (MEM), a N-methyl-D-aspartate receptor antagonist, is currently used for the treatment of AD. Nonetheless, few studies have reported its effects on genetic preclinical models of this neurodegenerative disease exacerbated with high-fat diet (HFD)-induced obesity...
February 5, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29363584/neurogenesis-during-abstinence-is-necessary-for-context-driven-methamphetamine-related-memory
#9
Melissa H Galinato, Yoshio Takashima, McKenzie J Fannon, Leon W Quach, Roberto J Morales Silva, Karthik K Mysore, Michael J Terranova, Rahul R Dutta, Ryan W Ostrom, Sucharita S Somkuwar, Chitra D Mandyam
Abstinence from methamphetamine addiction enhances proliferation and differentiation of neural progenitors and increases adult neurogenesis in the dentate gyrus (DG). We hypothesized that neurogenesis during abstinence contributes to context-driven drug-seeking behaviors. To test this hypothesis, the pharmacogenetic rat model (GFAP-TK rats) was used to conditionally and specifically ablate neurogenesis in the DG. Male GFAP-TK rats were trained to self-administer methamphetamine or sucrose and were administered the antiviral drug valganciclovir (Valcyte) to produce apoptosis of actively dividing GFAP type 1 stem-like cells to inhibit neurogenesis during abstinence...
February 21, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29348821/glycan-microarray-reveal-induced-iggs-repertoire-shift-against-a-dietary-carbohydrate-in-response-to-rabbit-anti-human-thymocyte-therapy
#10
Ron Amon, Shani Leviatan Ben-Arye, Limor Engler, Hai Yu, Noha Lim, Ludmilla Le Berre, Kristina M Harris, Mario R Ehlers, Stephen E Gitelman, Xi Chen, Jean-Paul Soulillou, Vered Padler-Karavani
Humans have circulating antibodies against diverse glycans containing N -glycolylneuraminic acid (Neu5Gc) due to function-loss mutation of the CMAH gene. This xenogenic non-human carbohydrate is abundant in red meat, xenografts and biotherapeutics. Low levels of diet-derived Neu5Gc is also present on normal human endothelial cells, and together with anti-Neu5Gc antibodies could potentially mediate "xenosialitis" chronic-inflammation. Rabbit anti-human thymocyte globulin (ATG) is a drug containing polyclonal IgG glycoproteins commonly used as an immunosuppressant in human transplantation and autoimmune diseases...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29318708/cocaine-conditioned-place-preference-unexpected-suppression-of-preference-due-to-testing-combined-with-strong-conditioning
#11
Lucile Marion-Poll, Antoine Besnard, Sophie Longueville, Emmanuel Valjent, Olivia Engmann, Jocelyne Caboche, Denis Hervé, Jean-Antoine Girault
Conditioned place preference (CPP) is widely used for evaluating the rewarding effects of drugs. Like other memories, CPP is proposed to undergo reconsolidation during which it is unstable and sensitive to pharmacological inhibition. Previous studies have shown that cocaine CPP can be apparently erased by extracellular signal-regulated kinase (ERK) pathway inhibition during cocaine reconditioning (re-exposure to the drug-paired environment in the presence of the drug). Here, we show that blockade of D1 receptors during reconditioning prevented ERK activation and induced a loss of CPP...
January 10, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29287214/favorable-adverse-effect-profile-of-brivaracetam-vs-levetiracetam-in-a-preclinical-model
#12
Nathalie T Sanon, Jonathan Gagné, Daniele C Wolf, Soumia Aboulamer, Ciprian M Bosoi, Alexe Simard, Estelle Messiet, Sébastien Desgent, Lionel Carmant
Levetiracetam (LEV), and its newer selective analog brivaracetam (BRV), are two seizure medications that share an innovative mechanism of action targeting the Synaptic Vesicle Protein 2A (SV2A), altering neurotransmitter release and decreasing seizure frequency. Behavioral changes are the most significant adverse effects reported by patients taking LEV. We hypothesize that BRV, the more potent SV2A analog, could exert less behavioral side effects, as it requires lower doses than LEV. Using Kainic Acid (KA)-treated and control rats, we measured adverse behavioral effect profiles of LEV, BRV, or Saline, on social and nonsocial behaviors...
February 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29284109/morin-hydrate-mitigates-rapid-eye-movement-sleep-deprivation-induced-neurobehavioural-impairments-and-loss-of-viable-neurons-in-the-hippocampus-of-mice
#13
Elizabeth T Olonode, Adegbuyi O Aderibigbe, Olusegun A Adeoluwa, Anthony T Eduviere, Benneth Ben-Azu
Rapid eye movement sleep deprivation distorts the body's homeostasis and results in oxidative breakdown which may be responsible for a variety of neurological disorders. Some naturally occurring compounds of plant origin with antioxidant and neuroprotective properties are known to attenuate the detrimental effects of REM sleep deprivation. Morin hydrate, a flavonoid from Mulberry has demonstrated antioxidant and neuroprotective activities but its effect in sleep disturbed mice is unknown. The study was designed to explore the neuroprotective effect of Morin hydrate on 48 h...
December 25, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29281030/motor-learning-and-metaplasticity-in-striatal-neurons-relevance-for-parkinson-s-disease
#14
Nadia Giordano, Attilio Iemolo, Maria Mancini, Fabrizio Cacace, Maria De Risi, Emanuele Claudio Latagliata, Veronica Ghiglieri, Gian Carlo Bellenchi, Stefano Puglisi-Allegra, Paolo Calabresi, Barbara Picconi, Elvira De Leonibus
Nigro-striatal dopamine transmission is central to a wide range of neuronal functions, including skill learning, which is disrupted in several pathologies such as Parkinson's disease. The synaptic plasticity mechanisms, by which initial motor learning is stored for long time periods in striatal neurons, to then be gradually optimized upon subsequent training, remain unexplored. Addressing this issue is crucial to identify the synaptic and molecular mechanisms involved in striatal-dependent learning impairment in Parkinson's disease...
February 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29225190/scopolamine-induced-passive-avoidance-memory-retrieval-deficit-is-accompanied-with-hippocampal-mmp2-mmp-9-and-mapks-alteration
#15
Maryam Moosavi, Roksana SoukhakLari, Leila Moezi, Fatema Pirsalami
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine is used to induce an animal model of amnesia. Howbeit the effect of scopolamine on memory retrieval is contradictory. This study aimed to assess the effect of scopolamine on passive avoidance memory retrieval...
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29214892/rutin-hydrate-ameliorates-cadmium-chloride-induced-spatial-memory-loss-and-neural-apoptosis-in-rats-by-enhancing-levels-of-acetylcholine-inhibiting-jnk-and-erk1-2-activation-and-activating-mtor-signalling
#16
Ghada A Abdel-Aleem, Eman F Khaleel
This study aimed at studying the potential neuroprotective effect of Rutin hydrate (RH) alone or in conjugation with α-tocopherol against cadmium chloride (CdCl2 )-induced neurotoxicity and cognitive impairment in rats and to investigate the mechanisms of action. Rats intoxicated with CdCl2 were treated with the vehicle, RH, α-tocopherol or combined treatment were examined, and compared to control rats received vehicle or individual doses of either drug. Data confirmed that RH improves spatial memory function by increasing acetylcholine availability, boosting endogenous antioxidant potential, activating cell survival and inhibiting apoptotic pathways, an effect that is more effective when RH was conjugated with α-tocopherol...
December 7, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29209218/nootropic-and-neuroprotective-effects-of-dichrocephala-integrifolia-on-scopolamine-mouse-model-of-alzheimer-s-disease
#17
Nadège E Kouémou, Germain S Taiwe, Fleur C O Moto, Simon Pale, Gwladys T Ngoupaye, Jacqueline S K Njapdounke, Gisèle C N Nkantchoua, David B Pahaye, Elisabeth Ngo Bum
Alzheimer's disease the most common form of dementia in the elderly is a neurodegenerative disease that affects 44 millions of people worldwide. The first treatments against Alzheimer's disease are acetylcholinesterase inhibitors; however, these medications are associated with many side effects. Dichrocephala integrifolia is a traditional herb widely used by indigenous population of Cameroon to treat and prevent Alzheimer's disease and for memory improvement. In this study, we evaluated the effect of the decoction prepared from leaves of D...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163130/sex-differences-in-the-cognitive-and-hippocampal-effects-of-streptozotocin-in-an-animal-model-of-sporadic-ad
#18
Jian Bao, Yacoubou A R Mahaman, Rong Liu, Jian-Zhi Wang, Zhiguo Zhang, Bin Zhang, Xiaochuan Wang
More than 95% of Alzheimer's disease (AD) belongs to sporadic AD (sAD), and related animal models are the important research tools for investigating the pathogenesis and developing new drugs for sAD. An intracerebroventricular infusion of streptozotocin (ICV-STZ) is commonly employed to generate sporadic AD animal model. Moreover, the potential impact of sex on brain function is now emphasized in the field of AD. However, whether sex differences exist in AD animal models remains unknown. Here we reported that ICV-STZ remarkably resulted in learning and memory impairment in the Sprague-Dawley male rats, but not in the female rats...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29113931/neurobiological-mechanisms-of-chemotherapy-induced-cognitive-impairment-in-a-transgenic-model-of-breast-cancer
#19
Gordon Winocur, Hal Berman, Mary Nguyen, Malcolm A Binns, Mark Henkelman, Matthijs van Eede, Micheline Piquette-Miller, Melanie J Sekeres, J Martin Wojtowicz, Johnson Yu, Haibo Zhang, Ian F Tannock
Animal studies have reinforced clinical reports of cognitive impairment in cancer survivors following chemotherapy but, until now, all pre-clinical research in this area has been conducted on normal rodents. The present study investigated the effects of chemotherapy on cognition and underlying biological mechanisms in the FVB/N-Tg (MMTV-neu) 202 Mul/J mouse, a well-characterized transgenic model of breast cancer that has similarities to the tumorigenesis which occurs in humans. Tumor-bearing and control mice received three weekly injections of a combination of methotrexate + 5-fluorouracil, or an equal volume of saline...
January 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29055813/amyloid-%C3%AE-synaptotoxicity-is-wnt-pcp-dependent-and-blocked-by-fasudil
#20
Katherine J Sellers, Christina Elliott, Joshua Jackson, Anshua Ghosh, Elena Ribe, Ana I Rojo, Heledd H Jarosz-Griffiths, Iain A Watson, Weiming Xia, Mikhail Semenov, Peter Morin, Nigel M Hooper, Rod Porter, Jane Preston, Raya Al-Shawi, George Baillie, Simon Lovestone, Antonio Cuadrado, Michael Harte, Paul Simons, Deepak P Srivastava, Richard Killick
INTRODUCTION: Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to synapses. We previously demonstrated that Aβ induces Dickkopf-1 (Dkk1), which in turn activates the Wnt-planar cell polarity (Wnt-PCP) pathway to drive tau pathology and neuronal death. METHODS: We compared the effects of Aβ and of Dkk1 on synapse morphology and memory impairment while inhibiting or silencing key elements of the Wnt-PCP pathway...
March 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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