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T6 T7 Spinal Cord Injury

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https://www.readbyqxmd.com/read/29070054/targeting-the-nlrp3-inflammasome-to-attenuate-spinal-cord-injury-in-mice
#1
Wu Jiang, Maoqiang Li, Fan He, Shaobo Zhou, Liulong Zhu
BACKGROUND: Spinal cord injury (SCI) is a devastating disease, which results in tissue loss and neurologic dysfunction. NLRP3 inflammasome plays an important role in the mechanism of diverse diseases. However, no studies have demonstrated the role of NLRP3 inflammasome and the effects of NLRP3 inflammasome inhibitors in a mouse model of SCI. We investigated whether inhibition of NLRP3 inflammasome activation by the pharmacologic inhibitor BAY 11-7082 or A438079 could exert neuroprotective effects in a mouse model of SCI...
October 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28868156/post-traumatic-syringomyelia-with-holocord-involvement-a-case-report
#2
Idris Amin, Gavriil Ilizarov, Nayeema Chowdhury, Shailaja Kalva
INTRODUCTION: Syringomyelia is a disorder in which a cyst, or syrinx, develops within the spinal cord. Historically, syringomyelia in post-traumatic spinal cord injury has been uncommon; however, its diagnosis has been increasing due to the advances in medical technology. Syringomyelia that involves the entire spinal cord, or holocord, is rare after traumatic spinal cord injury, with only a few cases reported in the literature. CASE PRESENTATION: We present a case of a 57-year-old male who had a motorcycle accident 30 years ago resulting in a spinal cord injury, who presented a rapid decline in the function of his left upper extremity...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28699368/impact-of-blood-pressure-lesion-level-and-physical-activity-on-aortic-augmentation-index-in-persons-with-spinal-cord-injury
#3
Caitlyn G Katzelnick, Joseph P Weir, Nancy D Chiaravalloti, Glenn R Wylie, Trevor A Dyson-Hudson, William A Bauman, Jill M Wecht
Individuals with chronic spinal cord injury (SCI) are at a heightened risk of cardiovascular disease (CVD) resulting from autonomic nervous system dysfunction, physical inactivity, and increased inflammatory processes. Arterial stiffness (AS) is recognized as an independent risk factor for CVD and, specifically, pulse wave analysis (PWA) has proven to be a useful tool to predict and track structural arterial changes that reflect arteriosclerosis. The augmentation index (AI) can be used to estimate AS and is derived from the amplitude and timing of the blood pressure (BP) wave reflection in a peripheral artery...
September 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28289632/hemodynamic-adaptations-to-regular-exercise-in-people-with-spinal-cord-injury
#4
Young Hee Lee, Jin Hyeong Lee, Sung Hoon Kim, Dongsoo Yi, Kyung Joon Oh, Ji Hyun Kim, Tae Jun Park, Hanul Kim, Jae Seung Chang, In Deok Kong
OBJECTIVE: To investigate the real-time cardiovascular response to the progressive overload exercise in different levels of spinal cord injury (SCI), and to find out whether regular exercise has effect on these cardiovascular responses. METHODS: The study enrolled 8 able-bodied individuals in the control group plus 15 SCI subjects who were divided into two groups by their neurological level of injury: high-level SCI group (T6 or above) and low-level SCI group (T7 or below)...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27889959/fumaric-acid-esters-attenuate-secondary-degeneration-after-spinal-cord-injury
#5
Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Spinal cord injury (SCI) causes permanent changes in motor, sensory, and autonomic functions. Unfortunately, there are no stable cures and current treatments include surgical decompression, methylprednisolone, and hemodynamic control that lead to modest function recovery. Fumaric acid esters (FAEs) were firstly used in the management of an immunological skin disorder, such as psoriasis. Because of their potent anti-inflammatory effects, they have been introduced in multiple sclerosis (MS). Investigation has shown not only an anti-inflammatory, but also supposed neuroprotective mechanism of action...
November 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27513198/is-the-wnt-%C3%AE-catenin-pathway-involved-in-the-anti-inflammatory-activity-of-glucocorticoids-in-spinal-cord-injury
#6
Rosaliana Libro, Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
The Wnt canonical or the Wnt/β-catenin pathway has been implicated in the regulation of several physiopathological pathways such as inflammation. Glucocorticoids (GCs) are administered widely to treat inflammation in several diseases, including spinal cord injury (SCI). The aim of this study was to evaluate whether the Wnt canonical pathway is involved in experimental SCI and whether it is implicated in the anti-inflammatory activity of two different GCs: the methylprednisolone sodium succinate (MPSS), considered the standard treatment for acute SCI, and mometasone furoate (MF), mainly administered for the treatment of airway and skin diseases...
September 28, 2016: Neuroreport
https://www.readbyqxmd.com/read/27431657/coronary-artery-disease-and-hypertension-in-a-non-selected-spinal-cord-injury-patient-population
#7
COMPARATIVE STUDY
E Aidinoff, V Bluvshtein, U Bierman, I Gelernter, L Front, A Catz
STUDY DESIGN: Retrospective observational comparative study. OBJECTIVES: The objectives of this study were to assess the atherosclerosis diseases and risk factors prevalence after spinal cored injury (SCI). SETTING: Loewenstein Rehabilitation Hospital, Israel. METHODS: Data of 154 traumatic and non-traumatic SCI patients were retrospectively collected. Coronary artery disease (CAD), myocardial infarction (MI), hypertension (HT) and risk factors for atherosclerotic diseases were examined after SCI for prevalence and effects, and compared with published corresponding data of the general population...
March 2017: Spinal Cord
https://www.readbyqxmd.com/read/27157316/prevalence-of-hypertension-and-associated-risk-factors-in-people-with-long-term-spinal-cord-injury-living-in-the-netherlands
#8
Jacinthe J E Adriaansen, Yvonne Douma-Haan, Floris W A van Asbeck, Casper F van Koppenhagen, Sonja de Groot, Christof A Smit, Johanna M A Visser-Meily, Marcel W M Post
PURPOSE: To describe the prevalence of hypertension and associated risk factors in people with long-term spinal cord injury (SCI) and to compare the prevalence of high blood pressure and/or the use of antihypertensive drugs with the prevalence in the Dutch general population. METHOD: Multicentre cross-sectional study (N = 282). Hypertension was defined as a systolic blood pressure (SBP) of ≥140 mmHg and/or a diastolic blood pressure (DBP) of ≥90 mmHg after ≥2 blood pressure measurements during ≥2 doctor visits...
May 9, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/26605167/changes-in-body-temperature-in-incomplete-spinal-cord-injury-by-digital-infrared-thermographic-imaging
#9
Yun-Gyu Song, Yu Hui Won, Sung-Hee Park, Myoung-Hwan Ko, Jeong-Hwan Seo
OBJECTIVE: To investigate changes in the core temperature and body surface temperature in patients with incomplete spinal cord injuries (SCI). In incomplete SCI, the temperature change is difficult to see compared with complete spinal cord injuries. The goal of this study was to better understand thermal regulation in patients with incomplete SCI. METHODS: Fifty-six SCI patients were enrolled, and the control group consisted of 20 healthy persons. The spinal cord injuries were classified according to International Standards for Neurological Classification of Spinal Cord Injury...
October 2015: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/26375085/inf-ir-5-b-cell-targeted-therapy-with-anti-cd20-monoclonal-antibody-reduced-secondary-tissue-damage-and-enhanced-behavioral-recovery-following-experimental-spinal-cord-injury-in-mice
#10
E Esposito, I Paterniti, M Cordaro, R Crupi, R Siracusa, S Cuzzocrea
INTRODUCTION: Traumatic injury to the spinal cord activates B cells, which culminates in the synthesis of autoantibodies. The functional significance of this immune response is unclear. Antibodies produced after SCI caused pathology, in part by activating intraspinal complement and cells bearing Fc receptors. These data indicate that B cells, through the production of antibodies, affect pathology in SCI. There is increasing appreciation of the important role of B cells in spinal cord trauma and consequently, increasing interest in treating these disorders through B cell-depletion therapy...
October 2015: Shock
https://www.readbyqxmd.com/read/25644387/a-modified-compression-model-of-spinal-cord-injury-in-rats-functional-assessment-and-the-expression-of-nitric-oxide-synthases
#11
Y-F Su, C-L Lin, K-S Lee, T-H Tsai, S-C Wu, S-L Hwang, S-C Chen, A-L Kwan
STUDY DESIGN: Experimental study. OBJECTIVES: To investigate a modified compression model of spinal cord injury (SCI) in adult rats by using a room-air- inflated Fogarty balloon catheter. SETTING: Kaohsiung, Taiwan. METHODS: The rats were divided into injury, sham-operated and control groups. A 2-French Fogarty catheter was passed from the lumbar spine (L3-L4) epidurally, with a mini-laminectomy under the microscope, to the level of thoracic spine (T6-T7)...
June 2015: Spinal Cord
https://www.readbyqxmd.com/read/25192008/effects-of-injury-level-and-severity-on-direct-costs-of-care-for-acute-spinal-cord-injury
#12
Mohan Radhakrishna, Ioli Makriyianni, Judith Marcoux, Xun Zhang
New treatments are being investigated for spinal cord injury (SCI), and any improvement may result in incremental cost savings. The objective of this study was to determine the direct costs of care 2 years after an SCI, stratifying for completeness and level of injury. A retrospective database analysis was carried out using data from the Quebec Trauma Registry, the Quebec Medical Insurance Board, and the Quebec Automobile Insurance Corporation between 1997 and 2007. Excluding individuals sustaining moderate or severe traumatic brain injuries, 481 individuals who sustained an SCI from motor vehicle accidents were identified...
December 2014: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/24827516/presence-of-trans-synaptic-neurons-derived-from-olfactory-mucosa-transplanted-after-spinal-cord-injury
#13
Takashi Moriwaki, Koichi Iwatsuki, Noriko Mochizuki-Oda, Yu-ichiro Ohnishi, Masahiro Ishihara, Masao Umegaki, Koshi Ninomiya, Toshiki Yoshimine
STUDY DESIGN: Using biotinylated dextran amine (BDA) and wheat germ agglutinin (WGA) tracers, we measured the effectiveness of olfactory mucosa (OM) transplantation as a scaffold in a rat model of chronic spinal cord injury (SCI). OBJECTIVE: We examined whether OM transplantation for chronic SCI in rats results in reconstruction of neuronal pathways by both regeneration of the remaining axons and supply of OM-derived trans-synaptic neurons. SUMMARY OF BACKGROUND DATA: OM is one of the ideal scaffolds for axonal regeneration after chronic SCI...
July 15, 2014: Spine
https://www.readbyqxmd.com/read/24237182/characterization-of-vascular-disruption-and-blood-spinal-cord-barrier-permeability-following-traumatic-spinal-cord-injury
#14
Sarah A Figley, Ramak Khosravi, Jean M Legasto, Yun-Fan Tseng, Michael G Fehlings
Significant vascular changes occur subsequent to spinal cord injury (SCI), which contribute to progressive pathophysiology. In the present study, we used female Wistar rats (300-350 g) and a 35-g clip-compression injury at T6 to T7 to characterize the spatial and temporal vascular changes that ensue post-SCI. Before sacrifice, animals were injected with vascular tracing dyes (2% Evans Blue (EB) or fluorescein isothiocyanate/Lycopersicon esculentum agglutinin [FITC-LEA]) to assess blood-spinal cord barrier (BSCB) integrity or vascular architecture, respectively...
March 15, 2014: Journal of Neurotrauma
https://www.readbyqxmd.com/read/23941794/a-retrospective-chart-review-of-heart-rate-and-blood-pressure-abnormalities-in-veterans-with-spinal-cord-injury
#15
Carolyn Zhu, Marinella Galea, Elayne Livote, Dan Signor, Jill M Wecht
OBJECTIVE: Autonomic impairment may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with spinal cord injury (SCI). In addition, comorbid medical conditions and prescription medication use may influence these abnormalities, including bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia (AD), and orthostatic hypotension (OH). DESIGN: A retrospective review of clinical and administrative datasets in veterans with SCI and compared the prevalence rates between clinical values and ICD-9 diagnostic codes in individuals with tetraplegia (T: C1-C8), high paraplegia (HP: T1-T6), and low paraplegia (LP: T7 and below)...
September 2013: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/23941793/a-prospective-report-on-the-prevalence-of-heart-rate-and-blood-pressure-abnormalities-in-veterans-with-spinal-cord-injuries
#16
Jill M Wecht, Carolyn Zhu, Joseph P Weir, Christina Yen, Christopher Renzi, Marinella Galea
OBJECTIVE: Decentralized autonomic cardiovascular regulation may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with SCI. In addition, comorbid medical conditions and prescription medication use may increase HR and BP abnormalities. These abnormalities include bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia and orthostatic hypotension; the prevalence of which is unknown. DESIGN: HR and BP data were measured during a routine annual physical examination in 64 veterans with SCI...
September 2013: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/23830951/a-re-assessment-of-the-effects-of-treatment-with-a-non-steroidal-anti-inflammatory-ibuprofen-on-promoting-axon-regeneration-via-rhoa-inhibition-after-spinal-cord-injury
#17
Kelli G Sharp, Kelly Matsudaira Yee, Travis L Stiles, Robert M Aguilar, Oswald Steward
This study was undertaken as part of the NIH "Facilities of Research Excellence-Spinal Cord Injury" project to support independent replication of published studies. Here, we repeat key parts of a study reporting that rats treated with ibuprofen via subcutaneous minipump exhibited greater recovery of motor function and enhanced axonal growth after spinal cord injury. We carried out 3 separate experiments in which young adult female Sprague-Dawley rats received dorsal over-hemisections at T6-T7, and then were implanted with osmotic minipumps for subcutaneous delivery of ibuprofen or saline...
October 2013: Experimental Neurology
https://www.readbyqxmd.com/read/23483223/h-fabp-cardiovascular-risk-factors-and-functional-status-in-asymptomatic-spinal-cord-injury-patients
#18
A Akbal, A Kurtaran, B Selçuk, M Akyüz
BACKGROUND: This was a cross-sectional study in the setting of a rehabilitation hospital. OBJECTIVE: The aim of the study was to determine the serum levels of heart-type fatty acid-binding protein (H-FABP) in patients with spinal cord injury (SCI). A further goal was to examine whether there is a relationship between H-FABP levels and Functional Ambulation Classification (FAC) scale, Functional Independence Measure (FIM) score, American Spinal Injury Association (ASIA) status, and metabolic syndrome (MetS)...
September 2013: Herz
https://www.readbyqxmd.com/read/22537532/anti-inflammatory-effect-of-simvastatin-in-an-experimental-model-of-spinal-cord-trauma-involvement-of-ppar-%C3%AE
#19
Emanuela Esposito, Barbara Rinaldi, Emanuela Mazzon, Maria Donniacuo, Daniela Impellizzeri, Irene Paterniti, Annalisa Capuano, Placido Bramanti, Salvatore Cuzzocrea
BACKGROUND: Statins such as simvastatin are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase used in the prevention of cardiovascular disease. In addition to their cholesterol-lowering activities, statins exert pleiotropic anti-inflammatory effects, which might contribute to their beneficial effects on lipid-unrelated inflammatory diseases. Recently it has been demonstrated that the peroxisome proliferator-activated receptor (PPAR)-α mediates anti-inflammatory effects of simvastatin in vivo models of acute inflammation...
2012: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/22330114/body-composition-modifications-in-people-with-chronic-spinal-cord-injury-after-supervised-physical-activity
#20
Frederico Ribeiro Neto, Guilherme Henrique Lopes
BACKGROUND: Quantification of body composition variables is important for planning of better activities in relation to individuals with spinal cord injury (SCI). OBJECTIVES: (1) To evaluate changes in body composition in patients with SCI after a supervised physical activity process; (2) To correlate total body fat with time since injury. DESIGN: Pre-post intervention. SETTING: Sarah Rehabilitation Hospital Network, Brazil...
November 2011: Journal of Spinal Cord Medicine
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