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T6 T7 Spinal Cord Injury

Rosaliana Libro, Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
The Wnt canonical or the Wnt/β-catenin pathway has been implicated in the regulation of several physiopathological pathways such as inflammation. Glucocorticoids (GCs) are administered widely to treat inflammation in several diseases, including spinal cord injury (SCI). The aim of this study was to evaluate whether the Wnt canonical pathway is involved in experimental SCI and whether it is implicated in the anti-inflammatory activity of two different GCs: the methylprednisolone sodium succinate (MPSS), considered the standard treatment for acute SCI, and mometasone furoate (MF), mainly administered for the treatment of airway and skin diseases...
September 28, 2016: Neuroreport
E Aidinoff, V Bluvshtein, U Bierman, I Gelernter, L Front, A Catz
STUDY DESIGN: Retrospective observational comparative study. OBJECTIVES: The objectives of this study were to assess the atherosclerosis diseases and risk factors prevalence after spinal cored injury (SCI). SETTING: Loewenstein Rehabilitation Hospital, Israel. METHODS: Data of 154 traumatic and non-traumatic SCI patients were retrospectively collected. Coronary artery disease (CAD), myocardial infarction (MI), hypertension (HT) and risk factors for atherosclerotic diseases were examined after SCI for prevalence and effects, and compared with published corresponding data of the general population...
July 19, 2016: Spinal Cord
Jacinthe J E Adriaansen, Yvonne Douma-Haan, Floris W A van Asbeck, Casper F van Koppenhagen, Sonja de Groot, Christof A Smit, Johanna M A Visser-Meily, Marcel W M Post
PURPOSE: To describe the prevalence of hypertension and associated risk factors in people with long-term spinal cord injury (SCI) and to compare the prevalence of high blood pressure and/or the use of antihypertensive drugs with the prevalence in the Dutch general population. METHOD: Multicentre cross-sectional study (N = 282). Hypertension was defined as a systolic blood pressure (SBP) of ≥140 mmHg and/or a diastolic blood pressure (DBP) of ≥90 mmHg after ≥2 blood pressure measurements during ≥2 doctor visits...
May 9, 2016: Disability and Rehabilitation
Yun-Gyu Song, Yu Hui Won, Sung-Hee Park, Myoung-Hwan Ko, Jeong-Hwan Seo
OBJECTIVE: To investigate changes in the core temperature and body surface temperature in patients with incomplete spinal cord injuries (SCI). In incomplete SCI, the temperature change is difficult to see compared with complete spinal cord injuries. The goal of this study was to better understand thermal regulation in patients with incomplete SCI. METHODS: Fifty-six SCI patients were enrolled, and the control group consisted of 20 healthy persons. The spinal cord injuries were classified according to International Standards for Neurological Classification of Spinal Cord Injury...
October 2015: Annals of Rehabilitation Medicine
E Esposito, I Paterniti, M Cordaro, R Crupi, R Siracusa, S Cuzzocrea
INTRODUCTION: Traumatic injury to the spinal cord activates B cells, which culminates in the synthesis of autoantibodies. The functional significance of this immune response is unclear. Antibodies produced after SCI caused pathology, in part by activating intraspinal complement and cells bearing Fc receptors. These data indicate that B cells, through the production of antibodies, affect pathology in SCI. There is increasing appreciation of the important role of B cells in spinal cord trauma and consequently, increasing interest in treating these disorders through B cell-depletion therapy...
October 2015: Shock
Y-F Su, C-L Lin, K-S Lee, T-H Tsai, S-C Wu, S-L Hwang, S-C Chen, A-L Kwan
STUDY DESIGN: Experimental study. OBJECTIVES: To investigate a modified compression model of spinal cord injury (SCI) in adult rats by using a room-air- inflated Fogarty balloon catheter. SETTING: Kaohsiung, Taiwan. METHODS: The rats were divided into injury, sham-operated and control groups. A 2-French Fogarty catheter was passed from the lumbar spine (L3-L4) epidurally, with a mini-laminectomy under the microscope, to the level of thoracic spine (T6-T7)...
June 2015: Spinal Cord
Mohan Radhakrishna, Ioli Makriyianni, Judith Marcoux, Xun Zhang
New treatments are being investigated for spinal cord injury (SCI), and any improvement may result in incremental cost savings. The objective of this study was to determine the direct costs of care 2 years after an SCI, stratifying for completeness and level of injury. A retrospective database analysis was carried out using data from the Quebec Trauma Registry, the Quebec Medical Insurance Board, and the Quebec Automobile Insurance Corporation between 1997 and 2007. Excluding individuals sustaining moderate or severe traumatic brain injuries, 481 individuals who sustained an SCI from motor vehicle accidents were identified...
December 2014: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
Takashi Moriwaki, Koichi Iwatsuki, Noriko Mochizuki-Oda, Yu-ichiro Ohnishi, Masahiro Ishihara, Masao Umegaki, Koshi Ninomiya, Toshiki Yoshimine
STUDY DESIGN: Using biotinylated dextran amine (BDA) and wheat germ agglutinin (WGA) tracers, we measured the effectiveness of olfactory mucosa (OM) transplantation as a scaffold in a rat model of chronic spinal cord injury (SCI). OBJECTIVE: We examined whether OM transplantation for chronic SCI in rats results in reconstruction of neuronal pathways by both regeneration of the remaining axons and supply of OM-derived trans-synaptic neurons. SUMMARY OF BACKGROUND DATA: OM is one of the ideal scaffolds for axonal regeneration after chronic SCI...
July 15, 2014: Spine
Sarah A Figley, Ramak Khosravi, Jean M Legasto, Yun-Fan Tseng, Michael G Fehlings
Significant vascular changes occur subsequent to spinal cord injury (SCI), which contribute to progressive pathophysiology. In the present study, we used female Wistar rats (300-350 g) and a 35-g clip-compression injury at T6 to T7 to characterize the spatial and temporal vascular changes that ensue post-SCI. Before sacrifice, animals were injected with vascular tracing dyes (2% Evans Blue (EB) or fluorescein isothiocyanate/Lycopersicon esculentum agglutinin [FITC-LEA]) to assess blood-spinal cord barrier (BSCB) integrity or vascular architecture, respectively...
March 15, 2014: Journal of Neurotrauma
Carolyn Zhu, Marinella Galea, Elayne Livote, Dan Signor, Jill M Wecht
OBJECTIVE: Autonomic impairment may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with spinal cord injury (SCI). In addition, comorbid medical conditions and prescription medication use may influence these abnormalities, including bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia (AD), and orthostatic hypotension (OH). DESIGN: A retrospective review of clinical and administrative datasets in veterans with SCI and compared the prevalence rates between clinical values and ICD-9 diagnostic codes in individuals with tetraplegia (T: C1-C8), high paraplegia (HP: T1-T6), and low paraplegia (LP: T7 and below)...
September 2013: Journal of Spinal Cord Medicine
Jill M Wecht, Carolyn Zhu, Joseph P Weir, Christina Yen, Christopher Renzi, Marinella Galea
OBJECTIVE: Decentralized autonomic cardiovascular regulation may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with SCI. In addition, comorbid medical conditions and prescription medication use may increase HR and BP abnormalities. These abnormalities include bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia and orthostatic hypotension; the prevalence of which is unknown. DESIGN: HR and BP data were measured during a routine annual physical examination in 64 veterans with SCI...
September 2013: Journal of Spinal Cord Medicine
Kelli G Sharp, Kelly Matsudaira Yee, Travis L Stiles, Robert M Aguilar, Oswald Steward
This study was undertaken as part of the NIH "Facilities of Research Excellence-Spinal Cord Injury" project to support independent replication of published studies. Here, we repeat key parts of a study reporting that rats treated with ibuprofen via subcutaneous minipump exhibited greater recovery of motor function and enhanced axonal growth after spinal cord injury. We carried out 3 separate experiments in which young adult female Sprague-Dawley rats received dorsal over-hemisections at T6-T7, and then were implanted with osmotic minipumps for subcutaneous delivery of ibuprofen or saline...
October 2013: Experimental Neurology
A Akbal, A Kurtaran, B Selçuk, M Akyüz
BACKGROUND: This was a cross-sectional study in the setting of a rehabilitation hospital. OBJECTIVE: The aim of the study was to determine the serum levels of heart-type fatty acid-binding protein (H-FABP) in patients with spinal cord injury (SCI). A further goal was to examine whether there is a relationship between H-FABP levels and Functional Ambulation Classification (FAC) scale, Functional Independence Measure (FIM) score, American Spinal Injury Association (ASIA) status, and metabolic syndrome (MetS)...
September 2013: Herz
Emanuela Esposito, Barbara Rinaldi, Emanuela Mazzon, Maria Donniacuo, Daniela Impellizzeri, Irene Paterniti, Annalisa Capuano, Placido Bramanti, Salvatore Cuzzocrea
BACKGROUND: Statins such as simvastatin are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase used in the prevention of cardiovascular disease. In addition to their cholesterol-lowering activities, statins exert pleiotropic anti-inflammatory effects, which might contribute to their beneficial effects on lipid-unrelated inflammatory diseases. Recently it has been demonstrated that the peroxisome proliferator-activated receptor (PPAR)-α mediates anti-inflammatory effects of simvastatin in vivo models of acute inflammation...
2012: Journal of Neuroinflammation
Frederico Ribeiro Neto, Guilherme Henrique Lopes
BACKGROUND: Quantification of body composition variables is important for planning of better activities in relation to individuals with spinal cord injury (SCI). OBJECTIVES: (1) To evaluate changes in body composition in patients with SCI after a supervised physical activity process; (2) To correlate total body fat with time since injury. DESIGN: Pre-post intervention. SETTING: Sarah Rehabilitation Hospital Network, Brazil...
November 2011: Journal of Spinal Cord Medicine
M Lefranc, J Peltier, A Fichten, P Toussaint, D Le Gars
BACKGROUND: We report on a dual percutaneous fixation in 2 patients with a double thoracic spine fracture. The advantages and limitations of this new approach for treating traumatic spinal fractures are reviewed. CLINICAL PRESENTATION: A 67-year-old male was admitted following a fall from a height of 3 m. A neurological examination revealed sub-T11 motor and sensory paraparesis. There were a T6 vertical body and bi-articular fracture and a T11 vertebral burst fracture with > 75% posterior wall damage...
October 2011: Minimally Invasive Neurosurgery: MIN
Rosanna Di Paola, Daniela Impellizzeri, Angela Trovato Salinaro, Emanuela Mazzon, Francesco Bellia, Monia Cavallaro, Carolin Cornelius, Graziella Vecchio, Vittorio Calabrese, Enrico Rizzarelli, Salvatore Cuzzocrea
L-Carnosine is an endogenously synthesized dipeptide composed of beta-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties. L-Carnosine reduces proinflammatory and profibrotic cytokines such as transforming growth factor-beta (TGF-beta), interleukin (IL)-1, and tumor necrosis factor (TNF)-alpha in different experimental settings. In the present study, we investigated the efficacy of L and D-carnosine on the animal model of spinal cord injury (SCI). The spinal cord was exposed via a four-level T5-T8 laminectomy and SCI was produced by extradural compression of the spinal cord at level T6-T7 using an aneurysm clip with a closing force of 24 g...
November 15, 2011: Biochemical Pharmacology
Fajing Liu, Yong Shen, Wenyuan Ding, Dalong Yang, Wei Du
OBJECTIVE: To investigate the effectiveness of transarticular approach in treating thoracic spinal stenosis due to ossification of ligamentum flavum (OLF) and ossification of posterior longitudinal ligament (OPLL) at the same level. METHODS: A retrospective analysis was performed in 35 patients with single-level thoracic spinal stenosis of calcified ligament who accepted transarticular approaching operation between January 2006 and March 2008. There were 12 males and 23 females with an age range of 40-67 years (mean, 58...
March 2011: Chinese Journal of Reparative and Reconstructive Surgery
Ashwin Avadhani, Ajoy P Shetty, S Rajasekaran
BACKGROUND CONTEXT: Multiple myeloma is the commonest primary malignancy of the spine, but it rarely presents as an extraosseous epidural tumor with only five cases reported in literature so far. PURPOSE: The purpose of this study was to heighten awareness and treatment options of a rare case of extraosseous epidural myeloma. STUDY DESIGN: The study design comprises a case report and literature review. METHODS: We present a 60-year-old lady with progressive paraplegia (American Spinal Injury Association grade C) with sensory blunting below T8 level of 2 months' duration...
April 2010: Spine Journal: Official Journal of the North American Spine Society
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw
The objective of this cadaveric study is to determine the safety and outcome of thoracic pedicle screw placement in Asians using the funnel technique. Pedicle screws have superior biomechanical as well as clinical data when compared to other methods of instrumentation. However, misplacement in the thoracic spine can result in major neurological implications. There is great variability of the thoracic pedicle morphometry between the Western and the Asian population. The feasibility of thoracic pedicle screw insertion in Asians has not been fully elucidated yet...
January 2010: European Spine Journal
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