Nechama Wieder, Elston N D'Souza, Alexandra C Martin-Geary, Frederik H Lassen, Jonathan Talbot-Martin, Maria Fernandes, Sonia P Chothani, Owen J L Rackham, Sebastian Schafer, Julie L Aspden, Daniel G MacArthur, Robert W Davies, Nicola Whiffin
BACKGROUND: Untranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of regulatory elements within them are known to vary substantially across genes, but little is known about the reasons for this variation in humans. Here, we set out to determine whether this variation, specifically in 5'UTRs, correlates with gene dosage sensitivity. RESULTS: We investigate 5'UTR length, the number of alternative transcription start sites, the potential for alternative splicing, the number and type of upstream open reading frames (uORFs) and the propensity of 5'UTRs to form secondary structures...
April 29, 2024: Genome Biology