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sodium imaging

P K Binsi, Natasha Nayak, P C Sarkar, A Jeyakumari, P Muhamed Ashraf, George Ninan, C N Ravishankar
The synergistic efficacy of gum arabic and sage polyphenols in stabilising capsule wall and protecting fish oil encapsulates from heat induced disruption and oxidative deterioration during spray drying was assessed. The emulsions prepared with sodium caseinate as wall polymer, gum arabic as wall co-polymer and sage extract as wall stabiliser was spray dried using a single fluid nozzle. Fish oil encapsulates stabilised with gum arabic and sage extract (SOE) exhibited significantly higher encapsulation efficiency compared to encapsulates containing gum arabic alone (FOE)...
March 15, 2017: Food Chemistry
Ming Yan, Guangming Zeng, Xiaoming Li, Jianmin He, Guiqiu Chen, Danlian Huang, Lin Tang, Cui Lai, Chang Zhang, Xiaodong Li, Lichao Wang, Zhi Guo, Wei Tao
Solidification is a very effective way to alleviate heavy metal impacts to the environment. In this paper, an improved method was adopted herein for the solidification/stabilization (S/S) of sediments with cement-based additives and low content of cement in S/S materials. Sediments in Xiangjiang River, containing high concentrations of Cu, Cd, and Pb, were solidified/stabilized by binders of cement, fly ash, and bentonite. Admixtures such as sodium lignosulfonate, sodium lauryl sulfate, and triethanolamine were used to improve the bonding properties of S/S, which had never been investigated before...
October 19, 2016: Environmental Science and Pollution Research International
Roland Schmieder, Christian Ott, Peter Linz, Agnes Jumar, Stefanie Friedrich, Jens Titze, Matthias Hammon, Michael Uder, Iris Kistner
OBJECTIVE: Sodium tissue content by Na magnetic resonance imaging (Na-MRI) has been validated in experimental and human studies. SGLT-2 inhibition blocks the reabsorption of glucose and, in parallel, of sodium in the proximal tubular cells in a 1:1 fashion. We hypothesized that SGLT-2 inhibition in patients with type 2 diabetes leads to decreased tissue sodium content due to its pharmacological action. DESIGN AND METHOD: In a prospective, double blind, placebo controlled, cross-over trial 59 patients (61 ± 7...
September 2016: Journal of Hypertension
Jianlong Wang, Say Hwa Tan, Anh V Nguyen, Geoffrey M Evans, Nam-Trung Nguyen
This paper reports the direct and precise measurement of bubble coalescence in salt solutions using microfluidics. We directly visualised the bubble coalescence process in a microchannel using high-speed imaging and evaluated the shortest coalescence time to determine the transition concentration of sodium halide solutions. We found the transition concentration is ion-specific and the capacity of sodium halide salts to inhibit bubble coalescence follows the order of NaF > NaCl > NaBr > NaI. The microfluidic method overcomes the inherent uncertainties in conventional large-scale devices and methods...
October 18, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Thomas Ebenhan, Isabel Schoeman, Daniel D Rossouw, Anne Grobler, Biljana Marjanovic-Painter, Judith Wagener, Hendrik G Kruger, Mike M Sathekge, Jan Rijn Zeevaart
PURPOSE: Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating Ga-68 from different generators was developed for NOTA-RGD and evaluated for its versatile use and safety in subsequent in vivo applications. The [(68)Ga]NOTA-RGD kit was further verified for its expected biodistribution and pharmacokinetics in nonhuman primates and its clinical sensitivity to detect solitary pulmonary nodules (SPN) in cancer patients...
October 14, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Svetlana Selivanova, Éric Lavallée, Helena Senta, Lyne Caouette, Alexander Jb McEwan, Brigitte Guérin, Roger Lecomte, Eric Turcotte
: A single-site prospective open-label clinical study with cyclotron-produced sodium pertechnetate (99m)Tc ([(99m)Tc]NaTcO4, (99m)Tc-pertechnetate) was performed in patients with indication for a thyroid scan to demonstrate the clinical safety and diagnostic efficacy of the drug and confirm its equivalence with conventional sodium pertechnetate (99m)Tc eluted from a generator. METHODS: Sodium pertechnetate (99m)Tc was produced with a cyclotron (24 MeV, 2 h irradiation) from enriched 100Mo (99...
October 13, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Stephania Caroline Rodolfo Silva, Aion Mangino Messias, Filipe de Oliveira Abi-Rached, Raphael Freitas de Souza, José Maurício Dos Santos Nunes Reis
This study evaluated the accuracy of gypsum casts after different impression techniques and double pouring. Ten patients were selected and for each one it was obtained 5 partial putty/wash impressions with vinyl polysiloxane (VPS) material from teeth #13 to #16 with partial metal stock trays. The following techniques were performed: (1) one-step; two-step relief with: (2) PVC film; (3) slow-speed tungsten carbide bur and scalpel blade, (4) small movements of the tray and (5) without relief-negative control...
2016: PloS One
T Ravindran, Paneerselvam, Radha, T Allwyn Yabesh
Osmotic demyelination syndrome is an acute shift in serum osmolality causing demyelination, which may be due to rapid correction of hyponatremia, hyperglycaemia, hypokalemia and ketoacidosis. We present a case of 55yr old female and a known diabetic presented with the choreic movements involving left upper and lower limb for 2 days without any weakness.Her blood sugar was 428mg/dl at the time of admission with wide fluctuations.Her CT Brain showed hyperdensity in the right basal ganglia and the MRI brain showed hyperintense lesion in T2 weighted images showing features suggestive of osmotic demyelination...
April 2016: Journal of the Association of Physicians of India
Charlotte Iacobaeus, Ellika Andolf, Malin Thorsell, Katarina Bremme, Gun JÖrneskog, Eva Östlund, Thomas Kahan
OBJECTIVE: To examine alterations in maternal vascular structure and function during normal pregnancy. METHODS: We assessed brachial and central blood pressure, pulse wave velocity and augmentation index (by pulse wave analysis and applanation tonometry), common carotid artery structure (by ultrasonography), and endothelial function in the brachial artery (by post-ischemic hyperemia induced flow mediated vasodilation and glyceryl nitrate) and in the forearm skin microcirculation (by laser Doppler perfusion imaging during iontophoretic administration of acetylcholine and sodium nitroprusside) in 52 healthy primiparous women at 14, 24 and 34 weeks of gestation, and nine months post partum...
October 12, 2016: Ultrasound in Obstetrics & Gynecology
Nunzio Denora, Angela Lopedota, Modesto De Candia, Saverio Cellamare, Leonardo Degennaro, Renzo Luisi, Antonietta Mele, Domenico Tricarico, Annalisa Cutrignelli, Valentino Laquintana, Cosimo D Altomare, Massimo Franco, Vincenzo Dimiccoli, Anna Tolomeo, Antonio Scilimati
6-[(18)F]fluoro-l-dihydroxyphenylalanine ((18)F-DOPA) is a diagnostic positron emission tomography (PET) agent, which has been used for decades in imaging the loss of dopaminergic neurons in Parkinson's disease, and more recently to detect, stage and restage neuroendocrine tumors (NETs) and to search for recurrence of viable glioma tissue. The commercially available (18)F-DOPA PET radiopharmaceutical for diagnostic use in European Union countries, is formulated in an aqueous solution of acetic acid (1.05mg/mL) and has the disadvantages that, immediately before injection, the pH must be adjusted to 4...
October 4, 2016: European Journal of Pharmaceutical Sciences
Maulee Hiromi Arambewela, Noel P Somasundaram, Chaminda Garusinghe
BACKGROUND: Hypernatremia is a frequent occurrence among hospitalized patients. Severe hypernatremia is associated with mortality rates of over 60 %. Extreme hypernatremia, defined as sodium levels >190 mmol/l, is a rare occurrence. The literature on electrocardiographic changes occurring with this degree of hypernatremia is extremely scarce. We report the case of an 11-year-old Sri Lankan girl who presented with sodium levels of 226 mmol/l following infusion with 3 % hypertonic saline who developed diffuse QT prolongation leading to fatal ventricular tachycardia...
October 1, 2016: Journal of Medical Case Reports
Justin A Neira, Timothy H Ung, Jennifer S Sims, Hani R Malone, Daniel S Chow, Jorge L Samanamud, George J Zanazzi, Xiaotao Guo, Stephen G Bowden, Binsheng Zhao, Sameer A Sheth, Guy M McKhann, Michael B Sisti, Peter Canoll, Randy S D'Amico, Jeffrey N Bruce
OBJECTIVE Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma (GBM). Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue, facilitating safe maximal resection of GBM. In this study, the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing (CE) regions, where this relationship has been established, and into the non-CE (NCE), diffusely infiltrated margins...
October 7, 2016: Journal of Neurosurgery
Joshua J Cardiel, Daisuke Takagi, Hsieh-Fu Tsai, Amy Q Shen
Understanding the formation and instability behavior of membranes is of fundamental interest and practical relevance to various biotechnological applications and self-assembly systems. Surfactant micellar membranes serve as a simple model system when surfactant molecules self-assemble into micellar structures under flow, but observing such process in real time is a major challenge due to limitations in spatiotemporal resolutions. We use a simple T-shaped microchannel to capture the formation and flow behavior of an ionic surfactant micro-micellar-membrane (μMM) when an aqueous stream of organic salt sodium salicylate (NaSal) meets a stream of cationic surfactant cetyltrimethylammonium bromide (CTAB)...
October 4, 2016: Soft Matter
Raghu Raj Singh Thakur, Ismaiel A Tekko, Farhan Al-Shammari, Ahlam A Ali, Helen McCarthy, Ryan F Donnelly
In this study, dissolving microneedles (MNs) were used to enhance ocular drug delivery of macromolecules. MNs were fabricated using polyvinylpyrrolidone (PVP) polymer of various molecular weights (MWs) containing three model molecules of increasing MW, namely fluorescein sodium and fluorescein isothiocyanate-dextrans (with MW of 70 k and 150 k Da). Arrays (3 × 3) of PVP MNs with conical shape measuring about 800 μm in height with a 300 μm base diameter, containing the model drugs, were fabricated and characterized for their fracture forces, insertion forces (in the sclera and cornea), depth of penetration (using OCT and confocal imaging), dissolution time and in vitro permeation...
October 5, 2016: Drug Delivery and Translational Research
Qiang Gao, Chao Huang, Binbin Sun, Bhutto M Aqeel, Jing Wang, Weiming Chen, Xiumei Mo, Xinjian Wan
Stent insertion and chemical agents of ethylene diamine tetraacetic acid and sodium cholate for dissolving common bile duct stone diseases through extra biliary tract infusion have been believed a relatively effective therapeutics for the clinical symptom. Core-shell nanofibers produced by co-axial electrospinning to deliver chemical drugs, biomacromolecules, genes and even cells have been reported for various advanced drug delivery system and tissue engineering applications. In the present study, poly (lactide-co-ɛ-caprolactone) (PLCL) core-shell nanofiber-coated film of stent, loaded with ethylene diamine tetraacetic acid and sodium cholate in core layer, was fabricated by co-axial electrospinning for treating gallstone disease...
October 3, 2016: Journal of Biomaterials Applications
Andrew Chu, Sameer Shaharyar, Binna Chokshi, Nikhil Bhardwaj
Pulmonary alveolar microlithiasis (PAM) is a rare infiltrative lung disease characterized by deposition of spherical calcium phosphate microliths called calcospherites within the alveoli. PAM was first described by Friedrich in 1856 and then by Harbitz in 1918. The disease pathogenesis is based on mutations in the SLC34A2 gene that encodes for the Type IIb sodium-phosphate cotransporter. The majority of the patients are diagnosed at an early age, usually between the ages of 20 and 40 years. The hallmark of this disease is a striking dissociation between the radiological findings and the mild clinical symptoms...
August 24, 2016: Curēus
Fabio Rosario Salerno, Grace Parraga, Christopher William McIntyre
Dyspnea is one of the most common symptoms associated with CKD. It has a profound influence on the quality of life of CKD patients, and its underlying causes are often associated with a negative prognosis. However, its pathophysiology is poorly understood. While hemodialysis may address fluid overload, it often does not significantly improve breathlessness, suggesting multiple and co-existing alternative issues exist. The aim of this article is to discuss the main pathophysiologic mechanisms and the most important putative etiologies underlying dyspnea in CKD patients...
September 28, 2016: Seminars in Dialysis
Charlotte Iacobaeus, Ellika Andolf, Katarina Bremme, Gun Jörneskog, Eva Östlund, Malin Thorsell, Thomas Khan
AIM: This study aimed to examine alterations in maternal endothelial function during normal pregnancy. METHODS: We assessed endothelial function in the brachial artery (by post-ischemic hyperemia-induced flow-mediated vasodilation and glyceryl nitrate) and in the forearm skin microcirculation (by laser Doppler perfusion imaging and iontophoretic administration of acetylcholine (Ach) and sodium nitroprusside (SNP)) in 53 healthy primiparous women at 14, 24 and 34 weeks of gestation, and nine months post-partum (non-pregnant state)...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Grzegorz Ćwik, Justyna Wyroślak-Najs, Michał Solecki, Grzegorz Wallner
AIM: The goal of the paper was to evaluate the procedure of percutaneous drainage of symptomatic hepatic cysts under the transabdominal ultrasound control combined with obliteration. MATERIAL AND METHOD: Within the period from 2005 to 2015, 70 patients diagnosed with a simple hepatic cyst of symptomatic nature were subject to hospitalization and treated at the 2(nd) General, Gastroenterological and Cancer Surgery of the Alimentary System Center and Clinics of the Medical University of Lublin...
September 2016: Journal of Ultrasonography
David D Frisbie, C Wayne McIlwraith, Christopher E Kawcak, Natasha M Werpy
OBJECTIVE To evaluate the efficacy of IV administration of a product containing hyaluronan, sodium chondroitin sulfate, and N-acetyl-d-glucosamine for prevention or treatment of osteoarthritis in horses. ANIMALS 32 healthy 2- to 5-year-old horses. PROCEDURES The study involved 2 portions. To evaluate prophylactic efficacy of the test product, horses received 5 mL of the product (n = 8) or saline (0.9% NaCl) solution (8; placebo) IV every fifth day, starting on day 0 (when osteoarthritis was induced in the middle carpal joint of 1 forelimb) and ending on day 70...
October 2016: American Journal of Veterinary Research
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