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https://www.readbyqxmd.com/read/28101399/stimulus-evoked-outer-segment-changes-occur-before-the-hyperpolarization-of-retinal-photoreceptors
#1
Yiming Lu, Benquan Wang, David R Pepperberg, Xincheng Yao
Transient retinal phototropism (TRP) has been predominantly observed in rod photoreceptors activated by oblique visible light stimulation. Dynamic confocal microscopy and optical coherence tomography (OCT) have revealed rod outer segment (ROS) movement as the physical source of TRP. However, the physiological source of ROS movement is still not well understood. In this study, concurrent near-infrared imaging of TRP and electroretinogram (ERG) measurement of retinal electrophysiology revealed that ROS movement occurs before the onset of the ERG a-wave, which is known to reflect the hyperpolarization of retinal photoreceptors...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101187/severe-pneumonia-due-to-infection-with-candida-krusei-in-a-case-of-suspected-middle-east-respiratory-syndrome-a-case-report-and-literature-review
#2
Mingming Tan, Junwei Wang, Peiyang Hu, Bin Wang, Wanghua Xu, Jiao Chen
Candida krusei (C. krusei) pneumonia is a rare infection that is frequently associated with a poor outcome. The present study reports an unusual case of C. krusei pneumonia that was initially suspected to be a Middle East respiratory syndrome (MERS) case. A 64-year-old Saudi Arabian male patient was admitted to our hospital with complaints of cough and dyspnea that persisted for 6 days. The patient presented fever (oral temperature, 38.5°C) and slight tachypnea (25 respirations/min). A chest computerized tomography demonstrated unclear lung fields, diffuse pathological changes in the two lungs and multiple lymphadenectasis in the retrocaval and para-aortic arch area...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28095484/experimental-diabetes-alters-the-morphology-and-nano-structure-of-the-achilles-tendon
#3
Rodrigo Ribeiro de Oliveira, Rômulo Medina de Mattos, Luciana Magalhães Rebelo, Fernanda Guimarães Meireles Ferreira, Fernanda Tovar-Moll, Luiz Eurico Nasciutti, Gerly Anne de Castro Brito
Although of several studies that associate chronic hyperglycemia with tendinopathy, the connection between morphometric changes as witnessed by magnetic resonance (MR) images, nanostructural changes, and inflammatory markers have not yet been fully established. Therefore, the present study has as a hypothesis that the Achilles tendons of rats with diabetes mellitus (DM) exhibit structural changes. The animals were randomly divided into two experimental groups: Control Group (n = 06) injected with a vehicle (sodium citrate buffer solution) and Diabetic Group (n = 06) consisting of rats submitted to intraperitoneal administration of streptozotocin...
2017: PloS One
https://www.readbyqxmd.com/read/28090810/enamel-remineralization-effect-of-a-dentifrice-containing-calcium-sodium-phosphosilicate-an-optical-coherence-tomography-observation
#4
Saki Matsuyoshi, Ryosuke Murayama, Shunsuke Akiba, Chiaki Yabuki, Toshiki Takamizawa, Hiroyasu Kurokawa, Masashi Miyazaki
OBJECTIVE: The purpose of this study was to examine the effects of a dentifrice containing 5% calcium sodium phosphosilicate (CSP) on the remineralization of the enamel using optical coherence tomography (OCT). MATERIALS AND METHODS: Bovine incisors were sliced and shaped in a rectangular form. One group of five specimens was treated with undersaturated 0.1 M lactic acid buffer solution (pH 4.75) for 10 min and then placed in artificial saliva (pH 7.0) (De group)...
January 16, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28090447/quantitative-sodium-magnetic-resonance-imaging-of-cartilage-muscle-and-tendon
#5
REVIEW
Neal K Bangerter, Grayson J Tarbox, Meredith D Taylor, Joshua D Kaggie
Sodium magnetic resonance imaging (MRI), or imaging of the 23Na nucleus, has been under exploration for several decades, and holds promise for potentially revealing additional biochemical information about the health of tissues that cannot currently be obtained from conventional hydrogen (or proton) MRI. This additional information could serve as an important complement to conventional MRI for many applications. However, despite these exciting possibilities, sodium MRI is not yet used routinely in clinical practice, and will likely remain strictly in the domain of exploratory research for the coming decade...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28081239/statistical-modeling-applied-to-deformation-relaxation-processes-in-a-composite-biopolymer-network-induced-by-magnetic-field
#6
Javier Tarrío-Saavedra, Cécilia Galindo González, Salvador Naya, Jorge López-Beceiro, Alain Ponton
This study investigated a methodology based on image processing and statistics to characterize and model the deformation upon controlled and uniform magnetic field and the relaxation under zero field of droplets observed in aqueous solutions of sodium alginate incorporating magnetic maghemite nanoparticles stabilized by adsorption of citrate ions. The changes of droplet geometry were statistically analyzed using a new approach based on the data obtained from optical microscopy, image processing, nonlinear regression, evolutionary optimization, analysis of variance and resampling...
2017: PloS One
https://www.readbyqxmd.com/read/28076008/pictorial-review-of-false-positive-results-on-radioiodine-scintigrams-of-patients-with-differentiated-thyroid-cancer
#7
Amy V Chudgar, Jagruti C Shah
Radioiodine has served an important role in the diagnostic workup and treatment of patients with differentiated thyroid cancer for more than 6 decades. The interpretation of radioiodine scintigraphic studies should be performed in conjunction with a comprehensive history, histopathologic correlation, and pertinent laboratory values, as well as correlation with available anatomic images and the findings from physical examination. A thorough understanding of the physiology and biodistribution of radioiodine is critical when interpreting radioiodine scintigraphic studies to avoid misinterpretation of physiologic and nonthyroid pathologic variants as thyroid cancer metastases...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28070701/use-of-a-continual-sweep-motion-to-compare-air-polishing-devices-powders-and-exposure-time-on-unexposed-root-cementum
#8
Mandy L Herr, Ralph DeLong, Yuping Li, Scott A Lunos, Jill L Stoltenberg
Low abrasive air polishing powders are a viable method for subgingival biofilm removal. This in vitro study evaluated the effects of air polishing using a standard tip on cementum following clinically recommended protocols. Forty-eight teeth were randomly divided into eight groups with six teeth per group. Teeth were treated using either a Hu-Friedy EMS or DENTSPLY Cavitron(®) air polishing device. One of three glycine powders (Air-flow 25 µm, Clinpro 45 μm, Clinpro+TCP 45 μm) or a sodium bicarbonate powder (NaHCO3  85 μm) was sprayed on cementum using a clinically relevant sweeping motion...
January 9, 2017: Odontology
https://www.readbyqxmd.com/read/28069705/multilevel-analyses-of-scn5a-mutations-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy-suggest-non-canonical-mechanisms-for-disease-pathogenesis
#9
Anneline S J M Te Riele, Esperanza Agullo-Pascual, Cynthia A James, Alejandra Leo-Macias, Marina Cerrone, Mingliang Zhang, Xianming Lin, Bin Lin, Nara L Sobreira, Nuria Amat-Alarcon, Roos F Marsman, Brittney Murray, Crystal Tichnell, Jeroen F van der Heijden, Dennis Dooijes, Toon A B van Veen, Harikrishna Tandri, Steven J Fowler, Richard N W Hauer, Gordon Tomaselli, Maarten P van den Berg, Matthew R G Taylor, Francesca Brun, Gianfranco Sinagra, Arthur A M Wilde, Luisa Mestroni, Connie R Bezzina, Hugh Calkins, J Peter van Tintelen, Lei Bu, Mario Delmar, Daniel P Judge
AIMS: Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) is often associated with desmosomal mutations. Recent studies suggest an interaction between the desmosome and sodium channel protein Nav1.5. We aimed to determine the prevalence and biophysical properties of mutations in SCN5A (the gene encoding Nav1.5) in ARVD/C. METHODS AND RESULTS: We performed whole-exome sequencing in six ARVD/C patients (33% male, 38.2 ± 12.1 years) without a desmosomal mutation...
January 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28064417/the-mmp-9-timp-1-system-is-involved-in-fluoride-induced-reproductive-dysfunctions-in-female-mice
#10
Hong-Wei Wang, Wen-Peng Zhao, Pan-Pan Tan, Jing Liu, Jing Zhao, Bian-Hua Zhou
A total of 84 healthy female mice were kept with various concentrations of sodium fluoride (F) (0, 50, 100, 150 mg F(-)/L in drinking water for 90 days) and were then mated with healthy male mice for 1 week to study the effect of excessive fluoride on female reproductive function, particularly in embryo implantation. The rate of pregnancy, litter size, and the birth weight of female mice were evaluated. Ultrastructural changes of uteri tissues were observed by transmission electron microscopy (TEM). The mRNA expression levels of MMP-9 and TIMP-1 were determined by quantitative real-time PCR...
January 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28057718/calcium-mediated-oxidative-stress-a-common-mechanism-in-tight-junction-disruption-by-different-types-of-cellular-stress
#11
Ruchika Gangwar, Avtar Meena, Pradeep Shukla, Archana Nagaraja, Piotr Dorniak, Sandeep Pallikuth, Christopher Waters, Anil Sood, Radhakrishna Rao
The role of reactive oxygen species (ROS) in osmotic stress, dextran sulfate sodium (DSS) and cyclic stretch-induced tight junction disruption was investigated in Caco-2 cell monolayers in vitro , and restraint stress-induced barrier dysfunction in mouse colon in vivo Live cell imaging showed that osmotic stress, cyclic stretch and DSS triggered rapid production of ROS in Caco-2 cell monolayers, which was blocked by depletion of intracellular Ca(2+) by BAPTA. Knockdown of CaV1.3 or TRPV6 channels blocked osmotic stress and DSS-induced ROS production and attenuated tight junction disruption and barrier dysfunction...
January 5, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#12
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28048911/su-g-iep1-06-estimating-relative-tissue-density-from-quantitative-mr-images-a-novel-perspective-for-mri-only-heterogeneity-corrected-dose-calculation
#13
A Soliman, M Hashemi, H Safigholi, E Tchistiakova, W Song
PURPOSE: To explore the feasibility of extracting the relative density from quantitative MRI measurements as well as estimate a correlation between the extracted measures and CT Hounsfield units. METHODS: MRI has the ability to separate water and fat signals, producing two separate images for each component. By performing appropriate corrections on the separated images, quantitative measurement of water and fat mass density can be estimated. This work aims to test this hypothesis on 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047654/mo-ab-bra-05-18f-naf-pet-ct-imaging-biomarkers-in-metastatic-prostate-cancer
#14
S Harmon, T Perk, C Lin, J Eickhoff, P Choyke, W Dahut, A Apolo, J Humm, S Larson, M J Morris, S Perlman, G Liu, R Jeraj
PURPOSE: Clinical use of (18) F-Sodium Fluoride (NaF) PET/CT in metastatic settings often lacks technology to quantitatively measure full disease dynamics due to high tumor burden. This study assesses radiomics-based extraction of NaF PET/CT measures, including global metrics of overall burden and local metrics of disease heterogeneity, in metastatic prostate cancer for correlation to clinical outcomes. METHODS: Fifty-six metastatic Castrate-Resistant Prostate Cancer (mCRPC) patients had NaF PET/CT scans performed at baseline and three cycles into chemotherapy (N=16) or androgen-receptor (AR) inhibitors (N=39)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047321/tu-ab-bra-04-an-investigation-of-metal-artifact-effects-in-multi-modalities-development-of-mri-ct-heterogeneous-head-and-neck-phantom-for-mri-ct-registration
#15
M Lee, K Song, B Choe, T Suh
PURPOSE: The purpose of this investigation was to develop an CT-MR head and neck phantom which can investigate dose calculation differences between density-assigned MRI and CT, and to compare non-implant inserted registered MR-CT registered image with artifact reduced image of MR-CT registered image. It is to identify potential limitations related to dental implants of MR image and CT image and maximize the advantages to find interactive method to use registered image. METHODS: The phantom comprises half-circled shape which shaped to simulated the anatomical structures of a human head and neck...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027835/toward-nitrogen-14-nuclear-quadrupole-resonance-imaging-by-nutation-experiments-performed-with-a-radio-frequency-field-gradient
#16
Sarra Aissani, Laouès Guendouz, Pierre-Louis Marande, Daniel Canet
Until now, NQR imaging has been considered mainly in the case of Chlorine-35. This is a spin 3/2 resonating at relatively high frequency (around 30MHz) thus affording a favorable sensitivity. Conversely, Nitrogen-14 (spin 1) NQR is much less sensitive because its resonances frequencies are below 6MHz. In contrast to already existing methodologies for object localization by (14)N NQR, we present here a new, more straightforward, approach and the principles of space dependent (14)N Quadrupole Resonance are laid down...
December 16, 2016: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28026925/elevated-performance-of-thin-film-nanocomposite-membranes-enabled-by-modified-hydrophilic-mofs-for-nanofiltration
#17
Junyong Zhu, Lijuan Qin, Adam Uliana, Jingwei Hou, Jing Wang, Yatao Zhang, Xin Li, Shushan Yuan, Jian Li, Miaomiao Tian, Jiuyang Lin, Bart Van der Bruggen
Metal-organic frameworks (MOFs) are studied for the design of advanced nanocomposite membranes, primarily due to their ultrahigh surface area, regular and highly tunable pore structures, and favorable polymer affinity. However, the development of engineered MOF-based membranes for water treatment lags behind. Here, thin-film nanocomposite (TFN) membranes containing poly(sodium 4-styrenesulfonate) (PSS) modified ZIF-8 (mZIF) in a polyamide (PA) layer were constructed via a facile interfacial polymerization (IP) method...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28019098/electrochemical-characterization-and-catalytic-application-of-gold-supported-ferrocene-containing-diblock-copolymer-thin-films-in-ethanol-solution
#18
Govinda Ghimire, Herman Coceancigh, Yi Yi, Takashi Ito
This paper reports the electrochemical behavior and catalytic property of electrode-supported thin films of polystyrene-block-poly(2-(acryloyloxy)ethyl ferrocenecarboxylate) (PS-b-PAEFc) in an ethanol (EtOH) solution. The electrochemical properties of PS-b-PAEFc films with different PAEFc volume fractions (fPAEFc = 0.47, 0.30, and 0.17) in 0.1 M ethanolic sodium hexafluorophosphate (NaPF6) were compared with those in an acetonitrile (MeCN) solution of 0.1 M tetrabutylammonium hexafluorophosphate. Pristine PS-b-PAEFc films did not afford significant faradaic currents in the EtOH solution because EtOH is a nonsolvent for both PS and PAEFc...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28019053/prestructural-cartilage-assessment-using-mri
#19
Thomas M Link, Jan Neumann, Xiaojuan Li
: Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy...
December 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28017842/measurement-of-spleen-stiffness-with-acoustic-radiation-force-impulse-imaging-predicts-mortality-and-hepatic-decompensation-in-patients-with-liver-cirrhosis
#20
Yoshitaka Takuma, Youichi Morimoto, Hiroyuki Takabatake, Nobuyuki Toshikuni, Junko Tomokuni, Akiko Sahara, Kazuhiro Matsueda, Hiroshi Yamamoto
BACKGROUND & AIMS: Hepatic venous pressure gradient (HVPG) can predict mortality and hepatic decompensation in patients with cirrhosis. Measurement of HVPG requires an invasive procedure; prognostic markers are needed that do not require invasive procedures. We investigated whether measurements of spleen stiffness, made by acoustic radiation force impulse (AFRI) imaging, associated with mortality and decompensation in patients with cirrhosis, compared to liver stiffness and other markers...
December 22, 2016: Clinical Gastroenterology and Hepatology
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