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David A Rincón

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https://www.readbyqxmd.com/read/29658612/let-7d-3p-is-associated-with-apoptosis-and-response-to-neoadjuvant-chemotherapy-in-ovarian-cancer
#1
Raúl García-Vázquez, Dolores Gallardo Rincón, Erika Ruiz-García, Abelardo Meneses García, Olga N Hernández De La Cruz, Horacio Astudillo-De La Vega, David Isla-Ortiz, Laurence A Marchat, Yarely M Salinas-Vera, Ángeles Carlos-Reyes, Sullivan López-González, Rosalio Ramos-Payan, César López-Camarillo
Altered expression of microRNAs contributes to the heterogeneous biological behavior of human malignancies and it may correlate with the clinical pathological features of patients. The let-7 microRNA family is frequently downregulated in human cancers and its aberrant expression may be a useful marker for prediction of the clinical response to therapy in patients. In the present study, we analyzed the expression of three members of the let-7 family (let-7a-3p, let-7d-3p and let-7f), which remains largely uncharacterized in ovarian cancer tissues...
April 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29615918/skeletal-muscle-pyruvate-dehydrogenase-phosphorylation-and-lactate-accumulation-during-sprint-exercise-in-normoxia-and-severe-acute-hypoxia-effects-of-antioxidants
#2
David Morales-Alamo, Borja Guerra, Alfredo Santana, Marcos Martin-Rincon, Miriam Gelabert-Rebato, Cecilia Dorado, José A L Calbet
Compared to normoxia, during sprint exercise in severe acute hypoxia the glycolytic rate is increased leading to greater lactate accumulation, acidification, and oxidative stress. To determine the role played by pyruvate dehydrogenase (PDH) activation and reactive nitrogen and oxygen species (RNOS) in muscle lactate accumulation, nine volunteers performed a single 30-s sprint (Wingate test) on four occasions: two after the ingestion of placebo and another two following the intake of antioxidants, while breathing either hypoxic gas (PI O2 = 75 mmHg) or room air (PI O2 = 143 mmHg)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29609459/modulating-antibody-structure-and-function-through-directed-mutations-and-chemical-rescue
#3
Christine Kaiser, Juan Pablo Rincon Pabon, Jake Khowsathit, Paola Castaldi, Steven L Kazmirski, David D Weis, Andrew X Zhang, John Karanicolas
Monoclonal antibody therapeutics have revolutionized the treatment of diseases such as cancer and autoimmune disorders, and also serve as research reagents for diverse and unparalleled applications. To extend their utility in both contexts, we have begun development of tunable antibodies, whose activity can be controlled by addition of a small molecule. Conceptually, we envision that incorporating cavity-forming mutations into an antibody can disrupt its structure, thereby reducing its affinity for antigen; addition of a small molecule may then restore the active structure, and thus rescue antigen binding...
April 2, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29463754/translational-control-in-the-tumor-microenvironment-promotes-lung-metastasis-phosphorylation-of-eif4e-in-neutrophils
#4
Nathaniel Robichaud, Brian E Hsu, Roman Istomine, Fernando Alvarez, Julianna Blagih, Eric H Ma, Sebastian V Morales, David L Dai, Glenn Li, Margarita Souleimanova, Qianyu Guo, Sonia V Del Rincon, Wilson H Miller, Santiago Ramón Y Cajal, Morag Park, Russell G Jones, Ciriaco A Piccirillo, Peter M Siegel, Nahum Sonenberg
The translation of mRNAs into proteins serves as a critical regulatory event in gene expression. In the context of cancer, deregulated translation is a hallmark of transformation, promoting the proliferation, survival, and metastatic capabilities of cancer cells. The best-studied factor involved in the translational control of cancer is the eukaryotic translation initiation factor 4E (eIF4E). We and others have shown that eIF4E availability and phosphorylation promote metastasis in mouse models of breast cancer by selectively augmenting the translation of mRNAs involved in invasion and metastasis...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29460373/examining-regional-variability-in-work-ethic-within-mexico-individual-difference-or-shared-value
#5
Luis M Arciniega, David J Woehr, Germán A Del Rincón
Despite the acceptance of work ethic as an important individual difference, little research has examined the extent to which work ethic may reflect shared environmental or socio-economic factors. This research addresses this concern by examining the influence of geographic proximity on the work ethic experienced by 254 employees from Mexico, working in 11 different cities in the Northern, Central and Southern regions of the country. Using a sequence of complementary analyses to assess the main source of variance on seven dimensions of work ethic, our results indicate that work ethic is most appropriately considered at the individual level...
February 19, 2018: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/29445118/n-1-methylnicotinamide-is-a-signalling-molecule-produced-in-skeletal-muscle-coordinating-energy-metabolism
#6
Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, Sine W Jörgensen, Peter Almgren, Yuedan Zhou, Marcos Martin-Rincon, Carl Ekman, Alberto Pérez-López, Ola Ekström, Ismael Perez-Suarez, Markus Mattiasson, Pedro de Pablos-Velasco, Nikolay Oskolkov, Emma Ahlqvist, Nils Wierup, Lena Eliasson, Allan Vaag, Leif Groop, Karin G Stenkula, Céline Fernandez, Jose A L Calbet, Hans-Christer Holmberg, Ola Hansson
Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To deeper understand molecular events occurring in muscle during weight-loss, we measured the expressional change in human skeletal muscle following a combination of severe caloric restriction and exercise over 4 days in 15 Swedish men. Key metabolic genes were regulated after the intervention, indicating a shift from carbohydrate to fat metabolism...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29239885/the-present-state-of-neurointensivist-training-in-the-united-states-a-comparison-to-other-critical-care-training-programs
#7
Evie G Marcolini, David B Seder, Jordan B Bonomo, Thomas P Bleck, J Claude Hemphill, Lori Shutter, Fred Rincon, Shelly D Timmons, Paul Nyquist
OBJECTIVE: This manuscript describes the state of neurocritical care fellowship training, compares its written standards to those of other critical care fellowship programs, and discusses how programmatic oversight by the United Council for Neurological Subspecialties should evolve to meet American College of Graduate Medical Education standards. This review is a work product of the Society of Critical Care Medicine Neuroscience section and was reviewed and approved by the Council of the Society of Critical Care Medicine...
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29233977/the-mitochondrial-negative-regulator-mcj-is-a-therapeutic-target-for-acetaminophen-induced-liver-injury
#8
Lucía Barbier-Torres, Paula Iruzubieta, David Fernández-Ramos, Teresa C Delgado, Daniel Taibo, Virginia Guitiérrez-de-Juan, Marta Varela-Rey, Mikel Azkargorta, Nicolas Navasa, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Jorge Simon, Fernando Lopitz-Otsoa, Sofia Lachiondo-Ortega, Javier Crespo, Steven Masson, Misti Vanette McCain, Erica Villa, Helen Reeves, Felix Elortza, Maria Isabel Lucena, Maria Isabel Hernández-Alvarez, Antonio Zorzano, Raúl J Andrade, Shelly C Lu, José M Mato, Juan Anguita, Mercedes Rincón, María Luz Martínez-Chantar
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second most common cause of liver failure. Mitochondrial dysfunction contributes to APAP-induced liver injury but the mechanism by which APAP causes hepatocyte toxicity is not completely understood. Therefore, we lack efficient therapeutic strategies to treat this pathology. Here we show that APAP interferes with the formation of mitochondrial respiratory supercomplexes via the mitochondrial negative regulator MCJ, and leads to decreased production of ATP and increased generation of ROS...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29208777/short-a%C3%AE-peptides-attenuate-a%C3%AE-42-toxicity-in-vivo
#9
Brenda D Moore, Jason Martin, Lorena de Mena, Jonatan Sanchez, Pedro E Cruz, Carolina Ceballos-Diaz, Thomas B Ladd, Yong Ran, Yona Levites, Thomas L Kukar, Justin J Kurian, Robert McKenna, Edward H Koo, David R Borchelt, Christopher Janus, Diego Rincon-Limas, Pedro Fernandez-Funez, Todd E Golde
Processing of amyloid-β (Aβ) precursor protein (APP) by γ-secretase produces multiple species of Aβ: Aβ40, short Aβ peptides (Aβ37-39), and longer Aβ peptides (Aβ42-43). γ-Secretase modulators, a class of Alzheimer's disease therapeutics, reduce production of the pathogenic Aβ42 but increase the relative abundance of short Aβ peptides. To evaluate the pathological relevance of these peptides, we expressed Aβ36-40 and Aβ42-43 in Drosophila melanogaster to evaluate inherent toxicity and potential modulatory effects on Aβ42 toxicity...
January 2, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28981652/prevalence-of-malnutrition-and-nutritional-characteristics-of-patients-with-inflammatory-bowel-disease
#10
María José Casanova, Maria Chaparro, Begoña Molina, Olga Merino, Ricardo Batanero, Carmen Dueñas-Sadornil, Pilar Robledo, Ana María Garcia-Albert, Maria Bienvenida Gómez-Sánchez, Xavier Calvet, Maria Del Roser Trallero, Miguel Montoro, Iria Vázquez, Mara Charro, Amaya Barragán, Francisco Martínez-Cerezo, Isabel Megias-Rangil, José María Huguet, Ezequiel Marti-Bonmati, Marta Calvo, Mariana Campderá, Margarita Muñoz-Vicente, Angel Merchante, Ansel David Ávila, Pilar Serrano-Aguayo, Ruth De Francisco, Daniel Hervías, Luis Bujanda, Gloria Esther Rodriguez, Luisa Castro-Laria, Manuel Barreiro-de Acosta, Manuel Van Domselaar, Patricia Ramirez de la Piscina, Javier Santos-Fernández, Alicia Algaba, Sandra Torra, Liliana Pozzati, Pilar López-Serrano, Maria Del Rosario Arribas, Maria Luisa Rincón, Andrés Camilo Peláez, Elena Castro, Antonio García-Herola, Cecilio Santander, Moisés Hernández-Alonso, Elisa Martín-Noguerol, María Gómez-Lozano, Tamara Monedero, Albert Villoria, Ariadna Figuerola, Andrés Castaño-García, Jesús M Banales, Laura Díaz-Hernández, Federico Argüelles-Arias, Javier López-Díaz, Isabel Pérez-Martínez, Noelia García-Talavera, Olivia Karina Nuevo-Siguairo, Sabino Riestra, Javier P Gisbert
Background and Aims: This study sought to determine the prevalence of malnutrition in patients with inflammatory bowel disease, to analyse the dietary beliefs and behaviours of these patients, to study their body composition, to evaluate their muscular strength and to identify the factors associated with malnutrition in these patients. Methods: This was a prospective, multicentre study. Crohn's disease and ulcerative colitis patients from 30 Spanish centres, from the outpatient clinics, were included...
December 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28930314/concerted-double-proton-transfer-electron-transfer-between-catechol-and-superoxide-radical-anion
#11
Jorge Quintero-Saumeth, David A Rincón, Markus Doerr, Martha C Daza
We have carried out a computational study on the reactivity of catechol (1,2-dihydroxybenzene) towards superoxide radical anion (O2 ˙- ) in water, N,N-dimethylformamide (DMF), pentyl ethanoate (PEA) and vacuum using density functional theory and the coupled cluster method. Five reaction mechanisms were studied: (i) sequential proton transfer followed by hydrogen atom transfer (PT-HT), (ii) sequential hydrogen atom transfer followed by proton transfer (HT-PT), (iii) single electron transfer (SET), (iv) radical adduct formation (RAF) and (v) concerted double proton-transfer electron-transfer (denoted as global reaction, GR)...
October 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819003/skeletal-muscle-signaling-metabolism-and-performance-during-sprint-exercise-in-severe-acute-hypoxia-after-the-ingestion-of-antioxidants
#12
David Morales-Alamo, Borja Guerra, Jesus Gustavo Ponce-Gonzalez, Amelia Guadalupe-Grau, Alfredo Santana, Marcos Martin-Rincon, Miriam Gelabert-Rebato, Joan Aureli Cadefau, Roser Cussó, Cecilia Dorado, Jose A L Calbet
The aim of this study was to determine reactive oxygen species (ROS) could play a role in blunting Thr(172)-AMPKα phosphorylation in human skeletal muscle after sprint exercise in hypoxia and to elucidate the potential signaling mechanisms responsible for this response. Nine volunteers performed a single 30s sprint (Wingate test) in two occasions while breathing hypoxic gas (PIO2=75 mmHg): one after the ingestion of placebo (P) and another following the intake of antioxidants (A) (α-lipoic acid, vitamin C, and vitamin E), with a randomized double-blind design...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28818546/glecaprevir-plus-pibrentasvir-for-chronic-hepatitis-c-virus-genotype-1-2-4-5-or-6-infection-in-adults-with-compensated-cirrhosis-expedition-1-a-single-arm-open-label-multicentre-phase-3-trial
#13
MULTICENTER STUDY
Xavier Forns, Samuel S Lee, Joaquin Valdes, Sabela Lens, Reem Ghalib, Humberto Aguilar, Franco Felizarta, Tarek Hassanein, Holger Hinrichsen, Diego Rincon, Rosa Morillas, Stefan Zeuzem, Yves Horsmans, David R Nelson, Yao Yu, Preethi Krishnan, Chih-Wei Lin, Jens J Kort, Federico J Mensa
BACKGROUND: The once-daily, ribavirin-free, pangenotypic, direct-acting antiviral regimen, glecaprevir coformulated with pibrentasvir, has shown high rates of sustained virological response in phase 2 and 3 studies. We aimed to assess the efficacy and safety of 12 weeks of coformulated glecaprevir and pibrentasvir in patients with hepatitis C virus (HCV) infection and compensated cirrhosis. METHODS: We did this single-arm, open-label, multicentre phase 3 study at 40 sites in Belgium, Canada, Germany, South Africa, Spain, and the USA...
October 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28790922/exercise-preserves-lean-mass-and-performance-during-severe-energy-deficit-the-role-of-exercise-volume-and-dietary-protein-content
#14
Jose A L Calbet, Jesús G Ponce-González, Jaime de La Calle-Herrero, Ismael Perez-Suarez, Marcos Martin-Rincon, Alfredo Santana, David Morales-Alamo, Hans-Christer Holmberg
The loss of fat-free mass (FFM) caused by very-low-calorie diets (VLCD) can be attenuated by exercise. The aim of this study was to determine the role played by exercise and dietary protein content in preserving the lean mass and performance of exercised and non-exercised muscles, during a short period of extreme energy deficit (~23 MJ deficit/day). Fifteen overweight men underwent three consecutive experimental phases: baseline assessment (PRE), followed by 4 days of caloric restriction and exercise (CRE) and then 3 days on a control diet combined with reduced exercise (CD)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28729389/severe-energy-deficit-up-regulates-leptin-receptors-leptin-signaling-and-ptp1b-in-human-skeletal-muscle
#15
Ismael Perez-Suarez, Jesus Gustavo Ponce-Gonzalez, Jaime de La Calle-Herrero, Jose Losa-Reyna, Marcos Martin-Rincon, David Morales-Alamo, Alfredo Santana, Hans-Christer Holmberg, Jose A L Calbet
In obesity, leptin receptors (OBR) and leptin signaling in skeletal muscle are down-regulated. To determine whether OBR and leptin signaling are up-regulated with a severe energy deficit fifteen overweight men were assessed before (PRE), after 4 days of caloric restriction (3.2 Kcal/kg BW/day) in combination with prolonged exercise (CRE) (8h walking + 45min single-arm cranking/day) to induce an energy deficit of ~5500 Kcal/d, and following 3 days of control diet (isoenergetic) and reduced exercise (CD). During CRE, the diet consisted solely of whey protein (n=8) or sucrose (n=7) (0...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28685860/exercise-mediated-modulation-of-autophagy-in-skeletal-muscle
#16
REVIEW
M Martin-Rincon, D Morales-Alamo, J A L Calbet
Although exercise exerts multiple beneficial health effects, it may also damage cellular structures. Damaged elements are continuously degraded and its constituents recycled to produce renovated structures through a process called autophagy, which is essential for the adaptation to training. Autophagy is particularly active in skeletal muscle, where it can be evaluated using specific molecular markers of activation (unc-51-like kinase 1 [ULK1] phosphorylation) and specific proteins indicating increased autophagosome content (increased total LC3, LC3-II, LC3-II/LC3-I ratio)...
July 7, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28449327/skeletal-muscle-il-15-il-15r%C3%AE-and-myofibrillar-protein-synthesis-after-resistance-exercise
#17
A Pérez-López, J McKendry, M Martin-Rincon, D Morales-Alamo, B Pérez-Köhler, D Valadés, J Buján, J A L Calbet, L Breen
In vitro and in vivo studies described the myokine IL-15 and its receptor IL-15Rα as anabolic/anti-atrophy agents, however, the protein expression of IL-15Rα has not been measured in human skeletal muscle and data regarding IL-15 expression remain inconclusive. The purpose of the study was to determine serum and skeletal muscle IL-15 and IL-15Rα responses to resistance exercise session and to analyze their association with myofibrillar protein synthesis (MPS). Fourteen participants performed a bilateral leg resistance exercise composed of four sets of leg press and four sets of knee extension at 75% 1RM to task failure...
January 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28375019/electrochemical-deprotection-of-para-methoxybenzyl-ethers-in-a-flow-electrolysis-cell
#18
Robert A Green, Katherine E Jolley, Azzam A M Al-Hadedi, Derek Pletcher, David C Harrowven, Oscar De Frutos, Carlos Mateos, David J Klauber, Juan A Rincón, Richard C D Brown
Electrochemical deprotection of p-methoxybenzyl (PMB) ethers was performed in an undivided electrochemical flow reactor in MeOH solution, leading to the unmasked alcohol and p-methoxybenzaldehyde dimethyl acetal as a byproduct. The electrochemical method removes the need for chemical oxidants, and added electrolyte (BF4NEt4) can be recovered and reused. The method was applied to 17 substrates with high conversions in a single pass, yields up to 92%, and up to 7.5 g h(-1) productivity. The PMB protecting group was also selectively removed in the presence of some other common alcohol protecting groups...
April 4, 2017: Organic Letters
https://www.readbyqxmd.com/read/28243944/serum-levels-of-p-glycoprotein-and-persistence-of-disease-activity-despite-treatment-in-patients-with-systemic-lupus-erythematosus
#19
Edsaul Emilio Perez-Guerrero, Jorge Ivan Gamez-Nava, Jose Francisco Muñoz-Valle, Ernesto German Cardona-Muñoz, David Bonilla-Lara, Nicte Selene Fajardo-Robledo, Arnulfo Hernan Nava-Zavala, Teresa Arcelia Garcia-Cobian, Ana Rosa Rincón-Sánchez, Jessica Daniela Murillo-Vazquez, David Cardona-Müller, Maria Luisa Vazquez-Villegas, Sylvia Elena Totsuka-Sutto, Laura Gonzalez-Lopez
Around 25% of patients with systemic lupus erythematosus (SLE) could be refractory to conventional therapies. P-glycoprotein expression on cell surface has been implied on drug resistance, however, to date, it is unknown if P-gp serum levels are associated with SLE disease activity. Evaluate the association of serum P-gp levels and SLE with disease activity despite treatment. A cross-sectional study was conducted on 93 female SLE patients, all receiving glucocorticoids at stable doses for the previous 6 months before to baseline...
February 27, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28236357/psychometric-properties-of-the-alabama-parenting-questionnaire-adapted-to-families-of-chilean-preschoolers
#20
Félix Cova, Claudio Bustos, Paulina Rincón, David L Streiner, Pamela Grandón, Sandra Saldivia, Carolina Inostroza, Gisela Contreras
The Alabama Parenting Questionnaire (APQ) is a well-known tool to assess empirically identified aspects of positive and negative parenting practices. This study evaluates the psychometric properties of an adapted version of the APQ for its use with parents of children between 2 and 6 years of age in Chile. The participants were 557 parents of children aged 2 to 6 years. A confirmatory factor analysis showed that the best fit was obtained by a four-factor model (positive reinforcement, parental involvement, inconsistency of disciplinary practices, and punitive practices)...
March 2017: Infant Mental Health Journal
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